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IBD
Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
Emiko Mizoguchi, Takayuki Sadanaga, Toshiyuki Okada, Takanori Minagawa, Jun Akiba
Intest Res 2023;21(3):306-317.   Published online April 20, 2023
DOI: https://doi.org/10.5217/ir.2022.00118
AbstractAbstract PDFPubReaderePub
Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates, and so on. Our group previously reported that oral administration of CAF efficiently suppressed the development of intestinal inflammation in a dextran sulfate sodium (DSS)-induced murine acute colitis model by suppressing the expression of chitinase 3-like 1, one of the mammalian chitinases without enzymatic activity. Chitinases are hydrolytic enzymes that break down chitin, a polymer of N-acetylglucosamine, and chitinase-like proteins have no enzymatic activity with preserving chitin-binding ability. CAF binds a cleft of the chitinase active site and plays a role as a pan-chitinase inhibitor. Although CAF showed an anti-inflammatory effect in the above model, oral administration of low-dose CAF with 10% sucrose showed potentially neoplastic effects in colonic epithelial cells in a DSS-induced murine chronic colitis model. In this review, we would like to discuss the pros and cons of coffee/CAF in colonic inflammation and neoplasia with an example of pathological finding.

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  • Strategies for enhancing sustainable and economic utilization of almond waste through a comprehensive multi-stage systematic approach to pathogen control
    Manjula Nishantha Udagepolage Don, Singarayer Florentine, Chris Turville, Kithsiri Dassanayake
    Journal of Natural Pesticide Research.2025; 12: 100126.     CrossRef
  • Caffeine modulates immunoproteasome activity and content in colorectal adenocarcinoma cells
    Alexander Burov, Alexander Rezvykh, Valeria Vedernikova, Alexey Belogurov, Vladimir Prassolov, Pavel Spirin, Sergey Funikov, Alexey Morozov, Vadim Karpov
    Biochimie.2025;[Epub]     CrossRef
  • Evaluation of the effect of roasting and digestion on biological activity of compounds of coffee extracts - in vitro assessment of the bioavailability, cytoprotective properties and modulation of inflammatory response
    Joanna Grzelczyk, Grażyna Budryn, Dominik Szwajgier, Ewa Baranowska-Wójcik, Małgorzata Zakłos-Szyda
    Food Chemistry.2024; 460: 140648.     CrossRef
  • Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation
    Emiko Mizoguchi, Takayuki Sadanaga, Linda Nanni, Siyuan Wang, Atsushi Mizoguchi
    Cells.2024; 13(8): 678.     CrossRef
  • Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo
    Yu Rim Kim, Soo-yeon Park, Ji Yeon Kim
    Journal of Functional Foods.2024; 123: 106563.     CrossRef
  • Dose–Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies
    Yuanyuan Dong, Darren Greenwood, James Webster, Chinwe Uzokwe, Jinhui Tao, Laura Hardie, Janet Cade
    Nutrients.2024; 16(23): 4050.     CrossRef
  • 6,205 View
  • 252 Download
  • 5 Web of Science
  • 6 Crossref
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IBD
Landscape of inflammatory bowel disease in Singapore
Daren Low, Nidhi Swarup, Toshiyuki Okada, Emiko Mizoguchi
Intest Res 2022;20(3):291-296.   Published online January 7, 2022
DOI: https://doi.org/10.5217/ir.2021.00089
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD), primarily Crohn’s disease and ulcerative colitis, had been widely recognized to affect the Western population. However, the notable rise in prevalence of IBD in Asia, including Singapore, had garnered much attention to the causal role of the shift in trend, and more importantly, effective and safe management of the conditions of these groups of patients in terms of therapy, healthcare economics as well as patient well-being. This review presents a summary of the current landscape of IBD in Singapore, and discuss on areas that can be explored to improve and better understand the local condition, as prevalence continues to grow.

Citations

Citations to this article as recorded by  
  • Optimizing 5-aminosalicylate for moderate ulcerative colitis: expert recommendations from the Asia-Pacific, Middle East, and Africa Inflammatory Bowel Disease Coalition
    Filiz Akyüz, Yoon Kyo An, Jakob Begun, Satimai Aniwan, Huu Hoang Bui, Webber Chan, Chang Hwan Choi, Nazeer Chopdat, Susan J Connor, Devendra Desai, Emma Flanagan, Taku Kobayashi, Allen Yu-Hung Lai, Rupert W Leong, Alex Hwong-Ruey Leow, Wai Keung Leung, Ju
    Intestinal Research.2025; 23(1): 37.     CrossRef
  • Trends and Factors Related to Quality of Life in Patients with Inflammatory Bowel Disease
    Sihyun Kim, Yu Kyung Jun, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
    Gut and Liver.2025; 19(2): 236.     CrossRef
  • Ocular extraintestinal manifestations and treatments in patients with inflammatory bowel disease
    Mariana Rodriguez Duran, Ghazala A. Datoo O’Keefe
    Frontiers in Ophthalmology.2024;[Epub]     CrossRef
  • Association of immune-mediated inflammatory diseases with depression and anxiety in patients with type 2 diabetes: A nationwide population-based study
    Oh Chan Kwon, Yuna Kim, Jaeyoung Chun, Kyungdo Han, Min-Chan Park, Ryul Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease
    You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
    Intestinal Research.2023; 21(4): 420.     CrossRef
  • Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study
    Xuejie Chen, Xin Xiang, Weitong Xia, Xindi Li, Sidan Wang, Shuyu Ye, Li Tian, Lian Zhao, Feiyan Ai, Zhaohua Shen, Kai Nie, Minzi Deng, Xiaoyan Wang
    Journal of Epidemiology and Global Health.2023; 13(4): 725.     CrossRef
  • Is primary sclerosing cholangitis with inflammatory bowel disease different between patients in the East and West?
    Yong Eun Park
    Intestinal Research.2022; 20(2): 157.     CrossRef
  • Vaccination strategies for Korean patients with inflammatory bowel disease
    Yoo Jin Lee, Eun Soo Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 920.     CrossRef
  • Clinical Characteristics of Korean Patients with Elderly-Onset Crohn’s Disease: Results from the Prospective CONNECT Study
    You Sun Kim, Min Jeong Na, Byong Duk Ye, Jae Hee Cheon, Jong Pil Im, Joo Sung Kim
    Gut and Liver.2022; 16(6): 995.     CrossRef
  • 7,463 View
  • 430 Download
  • 9 Web of Science
  • 9 Crossref
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Inflammatory bowel diseases
Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models
Emiko Mizoguchi, Daren Low, Yui Ezaki, Toshiyuki Okada
Intest Res 2020;18(2):151-167.   Published online April 20, 2020
DOI: https://doi.org/10.5217/ir.2019.09154
AbstractAbstract PDFPubReaderePub
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and both disorders affect individuals throughout life. Despite every extensive effort, the interplay among genetic factors, immunological factors, environmental factors and intestinal microbes is still completely unrevealed. Animal models are indispensable to find out mechanistic details that will facilitate better preclinical setting to target specific components involved in the pathogenesis of IBD. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, not only IBD but also colon cancer, obesity, psoriasis as well as allergic disorders, in both human and animal models. Advanced technologies including cell-specific and inducible knockout systems, which are recently employed to mouse IBD models, have further enhanced the ability of developing new therapeutic strategies for IBD. Furthermore, data from these mouse models highlight the critical involvement of dysregulated immune responses and impaired colonic epithelial defense system in the pathogenesis of IBD. In this review, we will explain from the history of animal models of IBD to the recent reports of the latest compounds, therapeutic strategies, and approaches tested on IBD animal models.

Citations

Citations to this article as recorded by  
  • DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering
    Oliver Sandys, Pieter C. F. Stokkers, Anje A. te Velde
    Digestive Diseases and Sciences.2025; 70(1): 49.     CrossRef
  • Eleven Grand Challenges for Inflammatory Bowel Disease Genetics and Genomics
    Greg Gibson, John D Rioux, Judy H Cho, Talin Haritunians, Akshaya Thoutam, Maria T Abreu, Steven R Brant, Subra Kugathasan, Jacob L McCauley, Mark Silverberg, Dermot McGovern
    Inflammatory Bowel Diseases.2025; 31(1): 272.     CrossRef
  • Biofabrication and simulation techniques for gut-on-a-chip
    Ke Wang, Yushen Wang, Junlei Han, Zhixiang Liang, Wenhong Zhang, Xinyu Li, Jun Chen, Li Wang
    Biofabrication.2025; 17(2): 022011.     CrossRef
  • Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibitor for the treatment of inflammatory bowel disease
    Jie Hu, Juan Liu, Fengming Zou, Xixiang Li, Hongwei Yu, Beilei Wang, Li Wang, Jun Tang, Xilu Hou, Qian Gao, Jiaoxue Wang, Xing He, Yanjie Chen, Hezhong Yan, Jing Liu, Aoli Wang, Wenchao Wang, Qingsong Liu
    International Immunopharmacology.2025; 159: 114839.     CrossRef
  • Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway
    Ruo Wang, Bing Feng, Qigu Yao, Qiaoling Pan, Jiong Yu, Chaoxu Liu, Jinhai Wang, Lanjuan Li, Hongcui Cao, Jue Xie
    Communications Biology.2025;[Epub]     CrossRef
  • Continued JAK inhibitor treatment on the risk of recurrent herpes zoster reactivation in patients with immune-mediated inflammatory diseases: A nationwide population-based study in South Korea
    Young-Eun Kim, Ye-Jee Kim, Dae Hyun Jeong, Seonok Kim, Min Jee Kim, Hyeon Hwa Kim, Kyung-Wook Jo, Sang Hyoung Park, Seokchan Hong
    Seminars in Arthritis and Rheumatism.2024; 65: 152362.     CrossRef
  • Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model
    Chunhua Yang, Didier Merlin
    Inflammatory Bowel Diseases.2024; 30(5): 844.     CrossRef
  • An evaluation of animal models for using bioactive compounds in the treatment of inflammatory bowel disease
    Shanshan Tie, Yannan Chen, Mingqian Tan
    Food Frontiers.2024; 5(2): 474.     CrossRef
  • Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products
    Tenzin Jamtsho, Karma Yeshi, Matthew J. Perry, Alex Loukas, Phurpa Wangchuk
    Pharmaceuticals.2024; 17(3): 283.     CrossRef
  • Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
    Natticha Sumneang, Komsak Pintha, Sarawut Kongkarnka, Maitree Suttajit, Napapan Kangwan
    Molecules.2024; 29(9): 1940.     CrossRef
  • Sacroiliitis in inflammatory bowel disease on abdominal computed tomography: prevalence, misses, and associated factors
    DK Kim, K-C Lee, JK Kim
    Scandinavian Journal of Rheumatology.2024; 53(4): 248.     CrossRef
  • Dopamine β-hydroxylase shapes intestinal inflammation through modulating T cell activation
    Qiaoling Sun, Heng Li, Jing Lv, Weilin Shi, Yanfeng Bai, Ke Pan, Alice Chen
    Cellular Immunology.2024; 401-402: 104839.     CrossRef
  • Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention
    Hong Huang, Gejing Li, Yini He, Jing Chen, Jianye Yan, Qin Zhang, Liqing Li, Xiong Cai
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Advances in Vascular Diagnostics using Magnetic Particle Imaging (MPI) for Blood Circulation Assessment
    Marisa O Pacheco, Isabelle K Gerzenshtein, Whitney L Stoppel, Carlos M Rinaldi‐Ramos
    Advanced Healthcare Materials.2024;[Epub]     CrossRef
  • Modelling the innate immune system in microphysiological systems
    Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. Hickman
    Lab on a Chip.2024; 24(15): 3604.     CrossRef
  • Bioinspired and bioderived nanomedicine for inflammatory bowel disease
    Rafaela Gazzi, Rita Gelli, Simone Aleandri, Marianna Carone, Paola Luciani
    WIREs Nanomedicine and Nanobiotechnology.2024;[Epub]     CrossRef
  • Target potential of miRNAs in ulcerative colitis: what do we know?
    Peeyush Kumar, Saurabh Kedia, Vineet Ahuja
    Expert Opinion on Therapeutic Targets.2024; 28(10): 829.     CrossRef
  • Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease
    Rucha Chandwaskar, Rajdeep Dalal, Saurabh Gupta, Aishwarya Sharma, Deepak Parashar, Vivek K. Kashyap, Jagdip Singh Sohal, Subhash K. Tripathi
    Scandinavian Journal of Immunology.2024;[Epub]     CrossRef
  • MiRNA-Based Therapies for the Treatment of Inflammatory Bowel Disease: What Are We Still Missing?
    Tommaso Innocenti, Elisabetta Bigagli, Erica Nicola Lynch, Andrea Galli, Gabriele Dragoni
    Inflammatory Bowel Diseases.2023; 29(2): 308.     CrossRef
  • Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation
    Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
    Cellular and Molecular Gastroenterology and Hepatology.2023; 15(2): 439.     CrossRef
  • Korean clinical practice guidelines on biologics for moderate to severe Crohn’s disease
    Seong-Joon Koh, Sung Noh Hong, Soo-Kyung Park, Byong Duk Ye, Kyeong Ok Kim, Jeong Eun Shin, Yong Sik Yoon, Hong Sub Lee, Sung Hoon Jung, Miyoung Choi, Soo-Young Na, Chang Hwan Choi, Joo Sung Kim
    Intestinal Research.2023; 21(1): 43.     CrossRef
  • Potential of Gut Microbe-Derived Extracellular Vesicles to Differentiate Inflammatory Bowel Disease Patients from Healthy Controls
    Min Heo, Young Soo Park, Hyuk Yoon, Nam-Eun Kim, Kangjin Kim, Cheol Min Shin, Nayoung Kim, Dong Ho Lee
    Gut and Liver.2023; 17(1): 108.     CrossRef
  • Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review
    Jung Yoon Jang, Eunok Im, Nam Deuk Kim
    International Journal of Molecular Sciences.2023; 24(3): 1954.     CrossRef
  • Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study
    Joo Kyung Kim, Jae Hee Cheon
    Journal of Yeungnam Medical Science.2023; 40(1): 37.     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • miRNA Molecules—Late Breaking Treatment for Inflammatory Bowel Diseases?
    Ioanna Aggeletopoulou, Athanasia Mouzaki, Konstantinos Thomopoulos, Christos Triantos
    International Journal of Molecular Sciences.2023; 24(3): 2233.     CrossRef
  • Succinate metabolism and its regulation of host-microbe interactions
    Yi-han Wei, Xi Ma, Jiang-chao Zhao, Xiu-qi Wang, Chun-qi Gao
    Gut Microbes.2023;[Epub]     CrossRef
  • A westernized diet changed the colonic bacterial composition and metabolite concentration in a dextran sulfate sodium pig model for ulcerative colitis
    Farhad M. Panah, Katrine D. Nielsen, Gavin L. Simpson, Anna Schönherz, Andreas Schramm, Charlotte Lauridsen, Tina S. Nielsen, Ole Højberg, Marlene Fredborg, Stig Purup, Nuria Canibe
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
    Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs, Marie-Laure Rives
    The Journal of Pharmacology and Experimental Therapeutics.2023; 386(1): 35.     CrossRef
  • The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
    Yu Kyung Jun, Da-Ae Yu, Yoo Min Han, Soo Ran Lee, Seong-Joon Koh, Hyunsun Park
    Dermatology and Therapy.2023; 13(7): 1465.     CrossRef
  • Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022
    Cuilan Huang, Wujuan Hao, Xuyang Wang, Renmin Zhou, Qiong Lin
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
    Silvana Leit, Jeremy Greenwood, Samantha Carriero, Sayan Mondal, Robert Abel, Mark Ashwell, Heather Blanchette, Nicholas A. Boyles, Mark Cartwright, Alan Collis, Shulu Feng, Phani Ghanakota, Geraldine C. Harriman, Vinayak Hosagrahara, Neelu Kaila, Rosanna
    Journal of Medicinal Chemistry.2023; 66(15): 10473.     CrossRef
  • Novel Histone Deacetylase 6 Inhibitor Confers Anti-inflammatory Effects and Enhances Gut Barrier Function
    Jae-Young Lee, Hyun Woo Ma, Ji Hyung Kim, I Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon
    Gut and Liver.2023; 17(5): 766.     CrossRef
  • Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease
    Kwang Woo Kim, Hyoun Woo Kang
    Intestinal Research.2023; 21(4): 413.     CrossRef
  • Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn’s Disease
    Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I Seul Park, Jae Hee Cheon, Duk Hwan Kim
    Gut and Liver.2023; 17(6): 905.     CrossRef
  • Immortalized Canine Adipose-Derived Mesenchymal Stem Cells Maintain the Immunomodulatory Capacity of the Original Primary Cells
    Yuyo Yasumura, Takahiro Teshima, Tomokazu Nagashima, Masaki Michishita, Takashi Takano, Yoshiaki Taira, Ryohei Suzuki, Hirotaka Matsumoto
    International Journal of Molecular Sciences.2023; 24(24): 17484.     CrossRef
  • Animal models of inflammatory bowel disease: category and evaluation indexes
    Changlin Wen, Dan Chen, Rao Zhong, Xi Peng
    Gastroenterology Report.2023;[Epub]     CrossRef
  • Recent development in zebrafish model for bioactivity and safety evaluation of natural products
    Fang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng, Ren-You Gan
    Critical Reviews in Food Science and Nutrition.2022; 62(31): 8646.     CrossRef
  • Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis
    Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai
    Journal of Gastroenterology and Hepatology.2022; 37(1): 81.     CrossRef
  • Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1
    Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, Chulho Choi, Gabriela Dower, Kathleen A. Farley, Margaret Fleming, Andrew Flick, Richard K. Frisbie, Justin Hall, David Hepworth, Hannah Jones, John D. Knafels, Steve Kortum, Frank E. Lovering, Jo
    Journal of Medicinal Chemistry.2022; 65(1): 757.     CrossRef
  • Copper oxide nanoparticles synthesized from Trichosanthes kirilowii ameliorates the DSS-induced acute colitis in mice through the suppression of inflammatory responses
    Xuefeng Jiang, Yu Sun, Tahani Awad Alahmadi, Velu Manikandan, Thamaraiselvan Rengarajan, Yuyang Zhao
    Journal of King Saud University - Science.2022; 34(3): 101817.     CrossRef
  • Screening and Evaluation of Probiotics for Reducing Intestinal Inflammation
    雅君 陈
    Hans Journal of Food and Nutrition Science.2022; 11(01): 44.     CrossRef
  • Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress
    Qian Chen, Ya-Li Zhang, Zi-Wei Zhang, Yu-Jun Chen, Ying-Jue Tang, Dan Qiao, Yan-Cheng Dai, Zhi-Peng Tang, Lu sa Mota da Silva
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Reactive Oxygen Species-Responsive Polyether Micelle Nanomaterials for Targeted Treatment of Ulcerative Colitis
    Xin-Xin Zhao, Shan-Bo Ma, Jin-Peng Wen, Da-Tao Hu, Ju-Shan Gao, Qiao Peng, Yu-Chen Zhang, Jin-Qing Wang, Ke Wang, Xiao-Peng Shi
    Journal of Biomedical Nanotechnology.2022; 18(1): 120.     CrossRef
  • Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1
    Olga Hartwig, Brigitta Loretz, Adrien Nougarede, Dorothée Jary, Eric Sulpice, Xavier Gidrol, Fabrice Navarro, Claus-Michael Lehr
    Journal of Controlled Release.2022; 345: 646.     CrossRef
  • Asymptomatic sacroiliitis detected by magnetic resonance enterography in patients with Crohn's disease: prevalence, association with clinical data, and reliability among radiologists in a multicenter study of adult and pediatric population
    Lorenzo Cereser, Giovanni Zancan, Ivan Giovannini, Carmelo Cicciò, Ilaria Tinazzi, Angela Variola, Matteo Bramuzzo, Flora Maria Murru, Marco Marino, Annarita Tullio, Salvatore De Vita, Rossano Girometti, Alen Zabotti
    Clinical Rheumatology.2022; 41(8): 2499.     CrossRef
  • Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?
    Sang Hyoung Park
    Intestinal Research.2022; 20(2): 159.     CrossRef
  • Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice
    Wenli Huang, Zeyuan Deng, Ling Lu, Yaoming Ouyang, Shuyuan Zhong, Ting Luo, Yawei Fan, Liufeng Zheng
    Food & Function.2022; 13(10): 5739.     CrossRef
  • Mesenchymal stem cell treatment for enteric neuropathy in the Winnie mouse model of spontaneous chronic colitis
    Ainsley M. Robinson, Rhian Stavely, Sarah Miller, Rajaraman Eri, Kulmira Nurgali
    Cell and Tissue Research.2022; 389(1): 41.     CrossRef
  • Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn’s Disease Recurrence
    Jongwook Yu, Hye Kyung Hyun, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2022; 16(3): 414.     CrossRef
  • Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
    Se Lim Kim, Min Woo Shin, Seung Young Seo, Sang Wook Kim
    Bioscience Reports.2022;[Epub]     CrossRef
  • Ulcerative Colitis and Patient’s Quality of Life, Especially in Early Stage
    Jung Won Lee
    Gut and Liver.2022; 16(3): 317.     CrossRef
  • Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function
    Mijeong Son, I Seul Park, Soochan Kim, Hyun Woo Ma, Ji Hyung Kim, Tae Il Kim, Won Ho Kim, Jaeyong Han, Seung Won Kim, Jae Hee Cheon
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs)
    Xue Yuan, Yong Chen, Minghai Tang, Yuhan Wei, Mingsong Shi, Yingxue Yang, Yanting Zhou, Tao Yang, Jiang Liu, Kongjun Liu, Dexin Deng, Chufeng Zhang, Lijuan Chen
    Journal of Medicinal Chemistry.2022; 65(13): 9312.     CrossRef
  • Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
    Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang
    Gut and Liver.2022; 16(4): 555.     CrossRef
  • The Common and Unique Pattern of Microbiome Profiles among Saliva, Tissue, and Stool Samples in Patients with Crohn’s Disease
    Seung Yong Shin, Sounkou Kim, Ji Won Choi, Sang-Bum Kang, Tae Oh Kim, Geom Seog Seo, Jae Myung Cha, Jaeyoung Chun, Yunho Jung, Jong Pil Im, Ki Bae Bang, Chang Hwan Choi, Soo-Kyung Park, Dong Il Park
    Microorganisms.2022; 10(7): 1467.     CrossRef
  • Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
    Kyunghwan Oh, Eun Ja Kwon, Jeong Hye Kim, Kyuwon Kim, Jae Yong Lee, Hee Seung Hong, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jeong Yun Park, Sang Hyoung Park
    The Ewha Medical Journal.2022; 45(2): 35.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
    Soo-Young Na, You Sun Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 906.     CrossRef
  • Improvement in Medication Adherence after Pharmacist Intervention Is Associated with Favorable Clinical Outcomes in Patients with Ulcerative Colitis
    Jae Song Kim, Min Jung Geum, Eun Sun Son, Yun Mi Yu, Jae Hee Cheon, Kyeng Hee Kwon
    Gut and Liver.2022; 16(5): 736.     CrossRef
  • Exploration of Potential Gut Microbiota-Derived Biomarkers to Predict the Success of Fecal Microbiota Transplantation in Ulcerative Colitis: A Prospective Cohort in Korea
    Gi-Ung Kang, Sowon Park, Yeongyun Jung, Jai J. Jee, Min-Sueng Kim, Seungjun Lee, Dong-Woo Lee, Jae-Ho Shin, Hong Koh
    Gut and Liver.2022; 16(5): 775.     CrossRef
  • Clinical applications and optimization of patient-derived organoids in intestinal diseases
    Tae Il Kim
    Organoid.2022; 2: e22.     CrossRef
  • Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
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