Skip Navigation
Skip to contents

Intest Res : Intestinal Research

Search
Advanced Search
IMPACT FACTOR
mobile search button mobile menu button

Search

Page Path
HOME > Search
27 "Vineet Ahuja"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
More +
Review
IBD
The practice of fecal microbiota transplantation in inflammatory bowel disease
Umang Arora, Saurabh Kedia, Vineet Ahuja
Intest Res 2024;22(1):44-64.   Published online November 21, 2023
DOI: https://doi.org/10.5217/ir.2023.00085
AbstractAbstract PDFPubReaderePub
Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the technical improvement including pretreatment with antibiotics, use of frozen stool samples as well as short donor-to-recipient time are proposed to improve its response rates. Its efficacy in ulcerative colitis has been proven in clinical trials while data is emerging for Crohn’s disease. This review describes briefly the biology behind FMT, the available evidence for its use in IBD, and the host, recipient and procedural factors which determine the clinical outcomes.

Citations

Citations to this article as recorded by  
  • Perception of fecal microbiota transplantation in patients with ulcerative colitis in Korea: a KASID multicenter study
    Jebyung Park, Sung Noh Hong, Hong Sub Lee, Jongbeom Shin, Eun Hye Oh, Kwangwoo Nam, Gyeol Seong, Hyun Gun Kim, Jin-Oh Kim, Seong Ran Jeon
    The Korean Journal of Internal Medicine.2024; 39(5): 783.     CrossRef
  • 3,579 View
  • 307 Download
  • 1 Crossref
Close layer
Original Articles
IBD
Serum albumin is the strongest predictor of anti-tumor necrosis factor nonresponse in inflammatory bowel disease in resource-constrained regions lacking therapeutic drug monitoring
Peeyush Kumar, Sudheer K. Vuyyuru, Prasenjit Das, Bhaskar Kante, Mukesh Kumar Ranjan, David Mathew Thomas, Sandeep Mundhra, Pabitra Sahu, Pratap Mouli Venigalla, Saransh Jain, Sandeep Goyal, Rithvik Golla, Shubi Virmani, Mukesh K. Singh, Karan Sachdeva, Raju Sharma, Nihar Ranjan Dash, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Intest Res 2023;21(4):460-470.   Published online March 17, 2023
DOI: https://doi.org/10.5217/ir.2022.00128
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Evidence on predictors of primary nonresponse (PNR), and secondary loss of response (SLR) to anti-tumor necrosis factor (anti-TNF) agents in inflammatory bowel disease is scarce from Asia. We evaluated clinical/biochemical/molecular markers of PNR/SLR in ulcerative colitis (UC) and Crohn’s disease (CD).
Methods
Inflammatory bowel disease patients treated with anti-TNF agents (January 2005–October 2020) were ambispectively included. Data concerning clinical and biochemical predictors was retrieved from a prospectively maintained database. Immunohistochemistry for expression of oncostatin M (OSM), OSM receptor (OSM-R), and interleukin-7 receptor (IL-7R) were done on pre anti-TNF initiation mucosal biopsies.
Results
One-hundred eighty-six patients (118 CD, 68 UC: mean age, 34.1±13.7 years; median disease duration at anti-TNF initiation, 60 months; interquartile range, 28–100.5 months) were included. PNR was seen in 17% and 26.5% and SLR in 47% and 28% CD and UC patients, respectively. In CD, predictors of PNR were low albumin (P<0.001), postoperative recurrence (P=0.001) and high IL-7R expression (P<0.027) on univariate; and low albumin alone (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.03–0.28; P<0.001) on multivariate analysis respectively. Low albumin (HR, 0.31; 95% CI, 0.15–0.62; P=0.001) also predicted SLR. In UC, predictors of PNR were low albumin (P<0.001), and high C-reactive protein (P<0.001), OSM (P<0.04) and OSM-R (P=0.07) stromal expression on univariate; and low albumin alone (HR, 0.11; 95% CI, 0.03–0.39; P=0.001) on multivariate analysis respectively.
Conclusions
Low serum albumin at baseline significantly predicted PNR in UC and PNR/SLR in CD patients. Mucosal markers of PNR were high stromal OSM/OSM-R in UC and high IL-7R in CD patients.

Citations

Citations to this article as recorded by  
  • Effectiveness of Switching to Subcutaneous Infliximab in Ulcerative Colitis Patients Experiencing Intravenous Infliximab Failure
    June Hwa Bae, Jung-Bin Park, Ji Eun Baek, Seung Wook Hong, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sung Wook Hwang
    Gut and Liver.2024; 18(4): 667.     CrossRef
  • Tofacitinib in Steroid-Refractory Acute Severe Ulcerative Colitis: A Retrospective Analysis
    Sayan Malakar, Srikanth Kothalkar, Umair Shamsul Hoda, Uday C Ghoshal
    Cureus.2023;[Epub]     CrossRef
  • 3,921 View
  • 434 Download
  • 2 Web of Science
  • 2 Crossref
Close layer
IBD
Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India
Arshdeep Singh, Vandana Midha, Vikram Narang, Saurabh Kedia, Ramit Mahajan, Pavan Dhoble, Bhavjeet Kaur Kahlon, Ashvin Singh Dhaliwal, Ashish Tripathi, Shivam Kalra, Narender Pal Jain, Namita Bansal, Rupa Banerjee, Devendra Desai, Usha Dutta, Vineet Ahuja, Ajit Sood
Intest Res 2023;21(4):452-459.   Published online December 2, 2022
DOI: https://doi.org/10.5217/ir.2022.00087
AbstractAbstract PDFPubReaderePub
Background/Aims
Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Limited data exist on PSC in patients with IBD from India. We aimed to assess the prevalence and disease spectrum of PSC in Indian patients with IBD.
Methods
Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively. Data were extracted and the prevalence of PSC-IBD was calculated.
Results
Forty-eight patients out of 12,216 patients with IBD (9,231 UC, 2,939 CD, and 46 IBD unclassified) were identified to have PSC, resulting in a prevalence of 0.39%. The UC to CD ratio was 7:1. Male sex and pancolitis (UC) or colonic CD were more commonly associated with PSC-IBD. The diagnosis of IBD preceded the diagnosis of PSC in most of the patients. Majority of the patients were symptomatic for liver disease at diagnosis. Eight patients (16.66%) developed cirrhosis, 5 patients (10.41%), all UC, developed malignancies (3 colorectal cancer [6.25%] and 2 cholangiocarcinoma [4.16%]), and 3 patients died (2 decompensated liver disease [4.16%] and 1 cholangiocarcinoma [2.08%]) on follow-up. None of the patients mandated surgical therapy for IBD.
Conclusions
Concomitant PSC in patients with IBD is uncommon in India and is associated with lower rates of development of malignancies.

Citations

Citations to this article as recorded by  
  • Frequency, spectrum and outcome of patients with primary sclerosing cholangitis among patients presenting with cholestatic jaundice
    Srikanth Kothalkar, Sayan Malakar, Piyush Mishra, Akash Mathur, Uday C. Ghoshal
    Indian Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
    You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
    Experimental & Molecular Medicine.2023; 55(7): 1380.     CrossRef
  • Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease
    You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
    Intestinal Research.2023; 21(4): 420.     CrossRef
  • Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease
    Kwang Woo Kim, Hyoun Woo Kang
    Intestinal Research.2023; 21(4): 413.     CrossRef
  • 4,361 View
  • 561 Download
  • 4 Web of Science
  • 4 Crossref
Close layer
Infection
Interferon-gamma release assay has poor diagnostic accuracy in differentiating intestinal tuberculosis from Crohn’s disease in tuberculosis endemic areas
Karan Sachdeva, Peeyush Kumar, Bhaskar Kante, Sudheer K. Vuyyuru, Srikant Mohta, Mukesh K. Ranjan, Mukesh K. Singh, Mahak Verma, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Intest Res 2023;21(2):226-234.   Published online June 13, 2022
DOI: https://doi.org/10.5217/ir.2022.00010
AbstractAbstract PDFPubReaderePub
Background/Aims
Intestinal tuberculosis (ITB) and Crohn’s disease (CD) frequently present with a diagnostic dilemma because of similar presentation. Interferon-gamma release assay (IGRA) has been used in differentiating ITB from CD, but with sparse reports on its diagnostic accuracy in tuberculosis endemic regions and this study evaluated the same.
Methods
Patients with definitive diagnosis of ITB (n=59) or CD (n=49) who underwent IGRA testing (n=307) were retrospectively included at All India Institute of Medical Sciences, New Delhi (July 2014 to September 2021). CD or ITB was diagnosed as per standard criteria. IGRA was considered positive at >0.35 IU/mL. Relevant data was collected and IGRA results were compared between ITB and CD to determine its accuracy.
Results
Among 59 ITB patients (mean age, 32.6±13.1 years; median disease duration, 1 year; male, 59.3%), 24 were positive and 35 tested negative for IGRA. Among 49 CD patients (mean age, 37.8±14.0; median disease duration, 4 years; male, 61.2%), 12 were positive and 37 tested negative for IGRA. Hence, for diagnosing ITB, IGRA showed a sensitivity, specificity, positive and negative predictive values of 40.68%, 75.51%, 66.67%, and 51.39%, respectively. The area under the curve of IGRA for ITB diagnosis was 0.66 (95% confidence interval, 0.55–0.75). In a subset (n=64), tuberculin skin test (TST) showed sensitivity, specificity, positive and negative predictive values of 64.7%, 73.3%, 73.3%, and 64.71%, respectively. IGRA and TST were concordant in 38 (59.4%) patients with κ=0.17.
Conclusions
In a tuberculosis endemic region, IGRA had poor diagnostic accuracy for differentiating ITB from CD, suggesting a limited value of IGRA in this setting.

Citations

Citations to this article as recorded by  
  • New diagnostic strategies to distinguish Crohn's disease and gastrointestinal tuberculosis
    Himanshu Narang, Saurabh Kedia, Vineet Ahuja
    Current Opinion in Infectious Diseases.2024; 37(5): 392.     CrossRef
  • Interferon-gamma release assays as a tool for differential diagnosis of gastrointestinal tuberculosis
    Tsvetelina Velikova, Anita Aleksandrova
    World Journal of Clinical Cases.2024; 12(27): 6015.     CrossRef
  • Diagnostic yield and technical performance of the novel motorized spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn's disease: a prospective study (with video)
    Partha Pal, Piyush Vishwakarma, Aniruddha Pratap Singh, Palle Manohar Reddy, Mohan Ramchandani, Rupa Banerjee, Anuradha Sekaran, Polina Vijayalaxmi, Hardik Rughwani, Pradev Inavolu, Santosh Darishetty, Pradeep Rebala, Guduru Venkat Rao, Manu Tandan, D. Na
    Gastrointestinal Endoscopy.2023; 97(3): 493.     CrossRef
  • Evidence-based approach to diagnosis and management of abdominal tuberculosis
    Daya Krishna Jha, Mythili Menon Pathiyil, Vishal Sharma
    Indian Journal of Gastroenterology.2023; 42(1): 17.     CrossRef
  • Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn’s disease: a randomised controlled, open-label study (the MOTOR-CD trial)
    Partha Pal, Mohan Ramchandani, Rupa Banerjee, Piyush Viswakarma, Aniruddha Pratap Singh, Manohar Reddy, Hardik Rughwani, Rajendra Patel, Anuradha Sekaran, Swathi Kanaganti, Santosh Darisetty, Zaheer Nabi, Jagadish Singh, Rajesh Gupta, Sundeep Lakhtakia, R
    Gut.2023; 72(10): 1866.     CrossRef
  • 3,865 View
  • 540 Download
  • 3 Web of Science
  • 5 Crossref
Close layer
Brief Communication
IBD
Correlation of fecal calprotectin and patient-reported outcome measures in patients with ulcerative colitis
Nagesh Kamat, Sudheer K Vuyyuru, Saurabh Kedia, Pabitra Sahu, Bhaskar Kante, Peeyush Kumar, Mukesh Kumar Ranjan, Mukesh Kumar Singh, Sambuddha Kumar, Vikas Sachdev, Govind Makharia, Vineet Ahuja
Intest Res 2022;20(2):269-273.   Published online February 8, 2022
DOI: https://doi.org/10.5217/ir.2021.00064
PDFSupplementary MaterialPubReaderePub

Citations

Citations to this article as recorded by  
  • Depression and active disease are the major risk factors for fatigue and sleep disturbance in inflammatory bowel disease with consequent poor quality of life: Analysis of the interplay between psychosocial factors from the developing world
    Partha Pal, Rupa Banerjee, Polina Vijayalaxmi, D. Nageshwar Reddy, Manu Tandan
    Indian Journal of Gastroenterology.2024; 43(1): 226.     CrossRef
  • Research Progress in the Study of Biomarkers for Diagnosing Ulcerative Colitis or Assessing Its Activity
    琳 杨
    Advances in Clinical Medicine.2024; 14(01): 1167.     CrossRef
  • A novel serum biomarker of endoscopic mucosal healing in inflammatory bowel disease
    Hyoun Woo Kang
    Intestinal Research.2024; 22(1): 3.     CrossRef
  • The prevalence and burden of Rome IV faecal incontinence in ulcerative colitis: A cross‐sectional study
    Dipesh H. Vasant, Gaurav B. Nigam, Sebastian Bate, Shaheen Hamdy, Jimmy K. Limdi
    Alimentary Pharmacology & Therapeutics.2023; 58(1): 26.     CrossRef
  • Current and emerging biomarkers for ulcerative colitis
    Jan K. Nowak, Rahul Kalla, Jack Satsangi
    Expert Review of Molecular Diagnostics.2023; 23(12): 1107.     CrossRef
  • 4,115 View
  • 278 Download
  • 4 Web of Science
  • 5 Crossref
Close layer
Original Articles
IBD
Efficacy and tolerability of hyperbaric oxygen therapy in small bowel stricturing Crohn’s disease: a pilot study
Bhaskar Kante, Pabitra Sahu, Saurabh Kedia, Sudheer K. Vuyyuru, Kapil Soni, Maneesh Singhal, Raju Sharma, Govind Makharia, Vineet Ahuja
Intest Res 2022;20(2):231-239.   Published online February 8, 2022
DOI: https://doi.org/10.5217/ir.2021.00056
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Existing therapeutic options for complicated Crohn’s disease (CD) like biologics and surgery are limited by inadequate long-term efficacy, cost, and adverse effects. Tissue hypoxia is important in CD pathogenesis and may be ameliorated with hyperbaric oxygen therapy (HBOT). We assessed the efficacy and tolerability of HBOT in small bowel stricturing CD.
Methods
This pilot study included patients of small bowel stricturing CD (from April 2019 to January 2020) who underwent HBOT. These patients were refractory to conventional medical treatment or had multiple strictures not amenable to resection. Each session of HBOT was given for 60 minutes with a pressure of 1.5–2.5 atm. Clinical, biochemical responses and Short Inflammatory Bowel Disease (SIBD) questionnaire were evaluated at 2 and 6 months, and radiological response was evaluated at 6 months.
Results
Fourteen patients (mean age, 42.9±15.7 years; male, 50%) were subjected to 168 HBOT sessions. Thirteen patients (92.7%) had strictures and 1 patient had enterocutaneous fistula in addition. Median number of HBOT sessions was 11 (range, 3–20) which were administered over a median of 4 weeks. Most patients tolerated it well except 1 who had hemotympanum. At 2 and 6 months of follow-up, 64.2% of patients had a clinical response, 50% and 64.2% of patients had clinical remission respectively. Steroid-free clinical remission was seen in 8 (57%) of patients with radiological improvement in 50%. There was a significant improvement in SIBD scores at 2-month follow-up (59.4 vs. 44.5, P=0.03).
Conclusions
HBOT can be a safe and effective therapeutic option in patients with stricturing small bowel CD refractory to conventional medical treatment.

Citations

Citations to this article as recorded by  
  • Hyperbaric oxygen therapy as a possible therapeutic candidate for sepsis-associated encephalopathy: A novel hypothesis
    Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
    Medical Hypotheses.2024; 182: 111212.     CrossRef
  • Treating paediatric Crohn’s disease is challenging but new treatments hold promise
    Tina Nie
    Drugs & Therapy Perspectives.2024; 40(3): 121.     CrossRef
  • Risk of avascular necrosis in patients with inflammatory bowel disease: Insights from a nationwide cohort study and the impact of corticosteroid use
    Jung Min Moon, Kyoung-Eun Kwon, Ju Won Lee, Kyung Rok Minn, Kyuwon Kim, Jeongkuk Seo, Seung Yong Shin, Sun-Young Jung, Chang Hwan Choi
    Digestive and Liver Disease.2024;[Epub]     CrossRef
  • The Future of Advanced Therapies for Pediatric Crohn’s Disease
    Julie Gallagher, Joel R. Rosh, Benjamin Sahn
    Pediatric Drugs.2023; 25(6): 621.     CrossRef
  • Role of hyperbaric oxygen therapy in patients with inflammatory bowel disease
    Harpreet Kaur, Gursimran Singh Kochhar, Parambir S. Dulai
    Current Opinion in Gastroenterology.2023; 39(4): 263.     CrossRef
  • 4,836 View
  • 295 Download
  • 5 Web of Science
  • 5 Crossref
Close layer
Miscellaneous
Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis
Saurabh Kedia, Raju Sharma, Sudheer Kumar Vuyyuru, Deepak Madhu, Pabitra Sahu, Bhaskar Kante, Prasenjit Das, Ankur Goyal, Karan Madan, Govind Makharia, Vineet Ahuja
Intest Res 2022;20(2):184-191.   Published online May 4, 2021
DOI: https://doi.org/10.5217/ir.2020.00104
AbstractAbstract PDFPubReaderePub
Background/Aims
Intestinal tuberculosis (ITB) is difficult to diagnose due to poor sensitivity of definitive diagnostic tests. ITB may be associated with concomitant pulmonary tuberculosis (PTB) which may remain undetected on chest X-ray. We assessed the role of contrast enhanced computed tomography (CECT) chest in detecting the prevalence of active PTB, and increasing the diagnostic yield in patients with suspected ITB.
Methods
Consecutive treatment naïve patients with suspected ITB (n=200) who underwent CECT chest (n=88) and had follow-up duration>1 year were recruited in this retrospective study (February 2016 to October 2018). ITB was diagnosed in the presence of caseating granuloma, positive acid fast stain or culture for Mycobacterium tuberculosis on biopsy, presence of necrotic lymph nodes (LNs) on CT enterography or positive response to anti-tubercular therapy. Evidence of active tuberculosis on CECT-chest was defined as presence of centrilobular nodules with or without consolidation/miliary nodules/thick-walled cavity/enlarged necrotic mediastinal LNs.
Results
Sixty-five of eighty-eight patients (mean age, 33.8±12.8 years; 47.7% of females) were finally diagnosed as ITB (4-caseating granuloma on biopsy, 12-necrotic LNs on CT enterography, 1-both, and 48-response to anti-tubercular therapy) and 23 were diagnosed as Crohn’s disease. Findings of active TB on CECT chest with or without necrotic abdominal LNs were demonstrated in 5 and 20 patients, respectively. No patient with Crohn’s disease had necrotic abdominal LNs or active PTB. Addition of CECT chest in the diagnostic algorithm improved the sensitivity of ITB diagnosis from 26.2% to 56.9%.
Conclusions
Addition of CECT chest significantly improves the sensitivity for definite diagnosis in a patient with suspected ITB.

Citations

Citations to this article as recorded by  
  • Imaging in Abdominal Tuberculosis
    Anuradha Sharma, Ankur Goyal, Devasenathipathy Kandasamy, Saurabh Kedia, Vineet Ahuja, Raju Sharma
    Indographics.2024; 03(02): 045.     CrossRef
  • Evidence-based approach to diagnosis and management of abdominal tuberculosis
    Daya Krishna Jha, Mythili Menon Pathiyil, Vishal Sharma
    Indian Journal of Gastroenterology.2023; 42(1): 17.     CrossRef
  • Risk factors identification of COVID‐19 patients with chronic obstructive pulmonary disease: A retrospective study in Punjab‐Pakistan
    Muhammad Muneeb Hassan, M. H. Tahir, Muhammad Ameeq, Farrukh Jamal, John T. Mendy, Christophe Chesneau
    Immunity, Inflammation and Disease.2023;[Epub]     CrossRef
  • Strengthening Tuberculosis Services for Children and Adolescents in Low Endemic Settings
    Jeffrey R. Starke, Connie Erkens, Nicole Ritz, Ian Kitai
    Pathogens.2022; 11(2): 158.     CrossRef
  • Stringent screening strategy significantly reduces reactivation rates of tuberculosis in patients with inflammatory bowel disease on anti‐TNF therapy in tuberculosis endemic region
    Peeyush Kumar, Sudheer K. Vuyyuru, Bhaskar Kante, Pabitra Sahu, Sandeep Goyal, Deepak Madhu, Saransh Jain, Mukesh Kumar Ranjan, Sandeep Mundhra, Rithvik Golla, Mukesh Singh, Shubi Virmani, Anvita Gupta, Nidhi Yadav, Mani Kalaivani, Raju Sharma, Prasenjit
    Alimentary Pharmacology & Therapeutics.2022; 55(11): 1431.     CrossRef
  • 5,929 View
  • 425 Download
  • 4 Web of Science
  • 5 Crossref
Close layer
Review
IBD
Use of thiopurines in inflammatory bowel disease: an update
Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N. Bernstein, Devendra Desai, C. Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce WY Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood
Intest Res 2022;20(1):11-30.   Published online April 15, 2021
DOI: https://doi.org/10.5217/ir.2020.00155
AbstractAbstract PDFPubReaderePub
Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight. 5-Aminosalicylates, corticosteroids, immunosuppressive agents and biologics are the backbone of treatment of IBD. With the advent of biologics and small molecules, the need for surgery and hospitalization has decreased. However, economic viability and acceptability is an important determinant of local prescription patterns. Nearly one-third of the patients in West receive biologics as the first/initial therapy. The scenario is different in developing countries where biologics are used only in a small proportion of patients with IBD. Increased risk of reactivation of tuberculosis and high cost of the therapy are limitations to their use. Thiopurines hence become critical for optimal management of patients with IBD in these regions. However, approximately one-third of patients are intolerant or develop adverse effects with their use. This has led to suboptimal use of thiopurines in clinical practice. This review article discusses the clinical aspects of thiopurine use in patients with IBD with the aim of optimizing their use to full therapeutic potential.

Citations

Citations to this article as recorded by  
  • Medical Management of Inflammatory Bowel Disease
    Shahrose Rahman, Ranish K. Patel, Elisa Boden, Vassiliki Liana Tsikitis
    Surgical Clinics of North America.2024; 104(3): 657.     CrossRef
  • Tofacitinib Versus Oral Prednisolone for Induction of Remission in Moderately Active Ulcerative Colitis [ORCHID]: A Prospective, Open-Label, Randomized, Pilot Study
    Arshdeep Singh, Vandana Midha, Kirandeep Kaur, Ramit Mahajan, Dharmatma Singh, Ramandeep Kaur, Aditya Kohli, Avantika Chawla, Kriti Sood, Namita Bansal, Ajit Sood
    Journal of Crohn's and Colitis.2024; 18(2): 300.     CrossRef
  • Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion
    Yasunori Fukumoto, Rin Kyono, Yuka Shibukawa, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra
    Journal of Biological Chemistry.2024; 300(2): 105599.     CrossRef
  • Factors Associated with Reaching Mid-Parental Height in Patients Diagnosed with Inflammatory Bowel Disease in Childhood and Adolescent Period
    So Yoon Choi, Sujin Choi, Byung-Ho Choe, Jae Hong Park, Kwang-Hae Choi, Hae Jeong Lee, Ji Sook Park, Ji-Hyun Seo, Jae Young Kim, Hyo-Jeong Jang, Suk Jin Hong, Eun Young Kim, Yeoun Joo Lee, Ben Kang
    Gut and Liver.2024; 18(1): 106.     CrossRef
  • Tofacitinib in Acute Severe Ulcerative Colitis (TACOS): A Randomized Controlled Trial
    Arshdeep Singh, Manjeet Kumar Goyal, Vandana Midha, Ramit Mahajan, Kirandeep Kaur, Yogesh Kumar Gupta, Dharmatma Singh, Namita Bansal, Ramandeep Kaur, Shivam Kalra, Omesh Goyal, Varun Mehta, Ajit Sood
    American Journal of Gastroenterology.2024; 119(7): 1365.     CrossRef
  • Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis
    Arshdeep Singh, Ramit Mahajan, Vandana Midha, Kirandeep Kaur, Dharmatma Singh, Ramandeep Kaur, Shreya Garg, Kirti Arora, Namita Bansal, Ajit Sood
    Digestive Diseases and Sciences.2024; 69(4): 1389.     CrossRef
  • Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care
    Ahmed B. Bayoumy, Chris J. J. Mulder, Azhar R. Ansari, Murray L. Barclay, Tim Florin, Marianne Kiszka-Kanowitz, Luc Derijks, Vishal Sharma, Nanne K. H. de Boer
    Indian Journal of Gastroenterology.2024; 43(1): 36.     CrossRef
  • The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study
    Helena Gensmyr-Singer, Mårten Werner, Pontus Karling
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Thiopurine Metabolite Shunting in Late Pregnancy Increases the Risk of Intrahepatic Cholestasis of Pregnancy in Women With Inflammatory Bowel Disease, and Can be Managed With Split Dosing
    Ralley Prentice, Emma Flanagan, Emily Wright, Lani Prideaux, William Connell, Miles Sparrow, Peter De Cruz, Mark Lust, Winita Hardikar, Rimma Goldberg, Sara Vogrin, Kirsten Palmer, Alyson Ross, Megan Burns, Tessa Greeve, Sally Bell
    Journal of Crohn's and Colitis.2024; 18(7): 1081.     CrossRef
  • Optimal Treatment Approaches to Intestinal Behçet's Disease Complicated by Myelodysplastic Syndrome: The KASID and KSBD Multicenter Study
    Jung-Bin Park, So Jung Han, Seung Bum Lee, Dong Hyun Kim, Jae Hee Cheon, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Soo Jung Park, Sang Hyoung Park
    Yonsei Medical Journal.2024; 65(5): 265.     CrossRef
  • Application of Drug Repurposing Approach for Therapeutic Intervention of Inflammatory Bowel Disease
    Mohammad Aadil Bhat, Iqra Usman, Suneela Dhaneshwar
    Current Reviews in Clinical and Experimental Pharmacology.2024; 19(3): 234.     CrossRef
  • Selecting first-line advanced therapy for ulcerative colitis: A clinical application of personalized medicine
    Mariam S. Mukhtar, Mahmoud H. Mosli
    Saudi Journal of Gastroenterology.2024; 30(3): 126.     CrossRef
  • Clinical Significance of Prognostic Nutrition Index in Patients with Crohn’s Disease after Primary Bowel Resection
    Hyeon Woo Bae, Yong Joon Lee, Min Young Park, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Jae Hee Cheon, Joseph C. Carmichael, Byung Soh Min
    Yonsei Medical Journal.2024; 65(7): 380.     CrossRef
  • Differences in the risk of clinical failure between thiopurine and methotrexate in bio-naïve patients with Crohn’s disease: a Korean nationwide population-based study
    Yu Kyung Jun, Eunjeong Ji, Hye Ran Yang, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Low risk of malignancies with thiopurines in an Indian cohort of patients with Inflammatory bowel disease
    Arshdeep Singh, Vandana Midha, Ajit Sood
    Indian Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Effectiveness of Switching to Subcutaneous Infliximab in Ulcerative Colitis Patients Experiencing Intravenous Infliximab Failure
    June Hwa Bae, Jung-Bin Park, Ji Eun Baek, Seung Wook Hong, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sung Wook Hwang
    Gut and Liver.2024; 18(4): 667.     CrossRef
  • Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease
    Tracy Coelho, Guo Cheng, Sophie Lewis, James J Ashton, Farah Barakat, Kouros C T Driscoll, Adebola E Sholeye-Bolaji, Akshay Batra, Nadeem A Afzal, Robert M Beattie, Sarah Ennis
    Inflammatory Bowel Diseases.2024;[Epub]     CrossRef
  • Reply: Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?
    Tracy Coelho, Guo Cheng, Fernando Vazquez Lopez, James J Ashton, Robert M Beattie, Sarah Ennis
    Inflammatory Bowel Diseases.2024; 30(10): 1928.     CrossRef
  • Safety and Effectiveness of Thiopurines and Small Molecules in Elderly Patients with Inflammatory Bowel Diseases
    Aleksandra Strigáč, Miłosz Caban, Ewa Małecka-Wojciesko, Renata Talar-Wojnarowska
    Journal of Clinical Medicine.2024; 13(16): 4678.     CrossRef
  • Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents
    Omar I. Saadah, Turki AlAmeel, Ahmed Al Sarkhy, Mohammed Hasosah, Abdulrahman Al-Hussaini, Majid A. Almadi, Badr Al-Bawardy, Talal A. Altuwaijri, Mohammed AlEdreesi, Shakir A. Bakkari, Othman R. Alharbi, Nahla A. Azzam, Abdulelah Almutairdi, Khalidah A. A
    Saudi Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Personalization of thiopurine therapy: Current recommendations and future perspectives
    Dunja Urbančič, Flaka Pasha, Alenka Šmid, Irena Mlinarič-Raščan
    Acta Pharmaceutica.2024; 74(3): 355.     CrossRef
  • Navigating the pharmacotherapeutic management of comorbid inflammatory bowel disease and primary sclerosing cholangitis
    Brigid Pinnuck, Kate D. Lynch
    Expert Opinion on Pharmacotherapy.2024;[Epub]     CrossRef
  • Thiopurine therapy in inflammatory bowel disease in the pandemic era: Safe or unsafe?
    Shailesh Perdalkar, Pooja Basthi Mohan, Balaji Musunuri, Siddheesh Rajpurohit, Shiran Shetty, Krishnamurthy Bhat, Cannanore Ganesh Pai
    International Immunopharmacology.2023; 116: 109597.     CrossRef
  • Effectiveness and safety of thioguanine as a maintenance therapy of inflammatory bowel disease: Systematic review, meta-analysis and meta-regression
    Anuraag Jena, Pardhu B Neelam, Harshavardhan Telaprolu, Uday Kiran Mangipudi, Usha Dutta, Shaji Sebastian, Vishal Sharma
    Clinics and Research in Hepatology and Gastroenterology.2023; 47(7): 102155.     CrossRef
  • Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
    Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
    Gut and Liver.2023; 17(4): 581.     CrossRef
  • Infectious complications in patients with inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
    Yu Kyung Jun, Seong-Joon Koh, Dae Seong Myung, Sang Hyoung Park, Choon Jin Ooi, Ajit Sood, Jong Pil Im
    Intestinal Research.2023; 21(3): 353.     CrossRef
  • The Management of Inflammatory Bowel Disease during Reproductive Years: An Updated Narrative Review
    Nariman Hossein-Javaheri, Michael Youssef, Yaanu Jeyakumar, Vivian Huang, Parul Tandon
    Reproductive Medicine.2023; 4(3): 180.     CrossRef
  • Long‐term safety and effectiveness of azathioprine in the management of inflammatory bowel disease: A real‐world experience
    Rohan V Yewale, Balakrishnan S Ramakrishna, Babu Vinish Doraisamy, Pandurangan Basumani, Jayanthi Venkataraman, Kayalvizhi Jayaraman, Ananthavadivelu Murali, Karunakaran Premkumar, Akkim Sathish Kumar
    JGH Open.2023; 7(9): 599.     CrossRef
  • Effectiveness and tolerability of methotrexate monotherapy in Crohn’s disease patients: a multicenter observational study
    Jihye Park, Jaeyoung Chun, Soo Jung Park, Jae Jun Park, Tae Il Kim, Hyuk Yoon, Jae Hee Cheon
    Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
  • Oral Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder Ameliorates Murine Colitis by Inhibiting Key Kinases Phosphorylation in MAPK Pathway
    Yingying Zhao, Liangchen Zhu
    International Journal of Medicinal Mushrooms.2023; 25(10): 39.     CrossRef
  • Enhancing cancer therapy: The potential of mercaptopurine-based nanomaterials for targeted drug delivery
    Mehrab Pourmadadi, Arsalan Rahmani Ghohrodi, Zeinab Savari, Ehsan Talebi, Iman Ahamdi, Abbas Rahdar, Sadanand Pandey
    Next Nanotechnology.2023; 2: 100018.     CrossRef
  • Thiopurine exposure during pregnancy is not associated with anemia in infants born to mothers with IBD
    Fiona Yeaman, Amelie Stritzke, Verena Kuret, Nastaran Sharifi, Cynthia H Seow, Amy Metcalfe, Yvette Leung
    Crohn's & Colitis 360.2023;[Epub]     CrossRef
  • Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis
    Apurva Jadhav, Suresh Jagtap, Suresh Vyavahare, Archana Sharbidre, Bipinraj Kunchiraman
    Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
  • Impact of Immunosuppressive Therapy on the Performance of Latent Tuberculosis Screening Tests in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Chan Hyuk Park, Jung Ho Park, Yoon Suk Jung
    Journal of Personalized Medicine.2022; 12(3): 507.     CrossRef
  • Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
    Bipadabhanjan Mallick, Sarthak Malik
    Cureus.2022;[Epub]     CrossRef
  • Ulcerative Colitis in Adulthood and in Older Patients: Same Disease, Same Outcome, Same Risks?
    Walter Fries, Maria Giulia Demarzo, Giuseppe Navarra, Anna Viola
    Drugs & Aging.2022; 39(6): 441.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Prevention of postoperative recurrence in Crohn’s disease: the never-ending story
    Jung-Bin Park, Sang Hyoung Park
    Intestinal Research.2022; 20(3): 279.     CrossRef
  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(5): 895.     CrossRef
  • Viral Hepatitis in Patients with Inflammatory Bowel Disease
    Seung Hwan Shin, Sang Hyoung Park
    The Korean Journal of Gastroenterology.2022; 80(2): 51.     CrossRef
  • Vaccination strategies for Korean patients with inflammatory bowel disease
    Yoo Jin Lee, Eun Soo Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 920.     CrossRef
  • Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study
    Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, Chang Hwan Choi
    Gut and Liver.2022; 16(5): 764.     CrossRef
  • A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients
    Debbie S. Deben, Rob H. Creemers, Arjan J. van Adrichem, Roosmarie Drent, Audrey H. H. Merry, Mathie P. G. Leers, Adriaan A. van Bodegraven, Dennis R. Wong
    Scientific Reports.2022;[Epub]     CrossRef
  • Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo
    Alexander Keith Turbayne, Miles Patrick Sparrow
    Digestive Diseases and Sciences.2022; 67(12): 5382.     CrossRef
  • NUDT15Genotyping in Thiopurine Drug Therapy
    Jong Kwon Lee, Rihwa Choi, Soo-Youn Lee
    Laboratory Medicine Online.2022; 12(4): 217.     CrossRef
  • Personalized medicine to implementation science: Thiopurines set for the leap
    Vishal Sharma, Saurabh Kedia, Vineet Ahuja
    JGH Open.2022; 6(10): 651.     CrossRef
  • Immunomodulators: still having a role?
    Jeffery M Venner, Charles N Bernstein
    Gastroenterology Report.2022;[Epub]     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis?
    Jin Wook Lee, Eun Soo Kim
    Gut and Liver.2021; 15(5): 639.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • Current status and future perspectives on the use of therapeutic drug monitoring of thiopurine metabolites in patients with inflammatory bowel disease
    Debbie S. Deben, Dennis R. Wong, Adriaan A. van Bodegraven
    Expert Opinion on Drug Metabolism & Toxicology.2021; 17(12): 1433.     CrossRef
  • 9,631 View
  • 649 Download
  • 49 Web of Science
  • 51 Crossref
Close layer
Original Articles
IBD
Maintaining infliximab induced clinical remission with azathioprine and 5-aminosalicylates in acute severe steroid-refractory ulcerative colitis has lower cost and high efficacy (MIRACLE): a multicenter study
Ramit Mahajan, Arshdeep Singh, Saurabh Kedia, Kirandeep Kaur, Vandana Midha, Pabitra Sahu, Varun Mehta, Dharmatma Singh, Namita Bansal, Khushdeep Dharni, Sandeep Kaushal, Vineet Ahuja, Ajit Sood
Intest Res 2022;20(1):64-71.   Published online February 3, 2021
DOI: https://doi.org/10.5217/ir.2020.00100
AbstractAbstract PDFPubReaderePub
Background/Aims
Infliximab (IFX) has been used to induce and maintain remission in patients with severe steroid-refractory ulcerative colitis (UC). Long-term use of biologics in developing countries is limited by high cost and frequent side effects. An optimal maintenance strategy in these patients needs to be established.
Methods
A retrospective analysis of maintenance of clinical remission with combination of azathioprine (AZA) and 5-aminosalicylates (5-ASA) in patients with severe steroidrefractory UC where IFX (5 mg/kg intravenously at weeks 0, 2, 6) had been used only as an induction therapy was done at 2 centers in India. Primary outcome was the proportion of patients maintaining corticosteroid-free sustained clinical remission (SCR) at the end of study period. Rates of relapse and cost of therapy were also analyzed.
Results
Of the 137 patients who received rescue IFX induction therapy, 77 (56.2%) achieved clinical remission (mean age 34.81 ± 13.32 years, 68.83% males, median follow-up 4 years, range 3 months to 6 years) and were included. Cumulative corticosteroid-free SCR was maintained in 68%, 59%, 42%, and 35% patients at 1, 2, 4, and 6 years respectively. Sixty-seven relapses were observed in 33 patients. Majority of the relapses (45/67, 67.16%) occurred within first 2 years of follow-up. Two relapses were managed with re-induction with IFX, one required colectomy, whereas all other responded to repeat course(s) of corticosteroids. Annual per capita maintenance therapy with 5-ASA and AZA was cheaper by US$ 4,526 compared to maintaining remission with IFX.
Conclusions
Clinical remission achieved with IFX induction therapy in severe steroid-refractory UC can be sustained over long time with a combination of AZA and 5-ASA.

Citations

Citations to this article as recorded by  
  • Effect of Ornithine α-Ketoglutarate on Intestinal Microbiota and Serum Inflammatory Cytokines in Dextran Sulfate Sodium Induced Colitis
    Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yin
    Nutrients.2023; 15(11): 2476.     CrossRef
  • Management of Ulcerative Colitis: A Review of Indian Literature
    Santhosh Rajendran, Ratnakar Kini, K. Muthukumaran, I. Shubha, A. Chezhian, R. Murali
    Gastroenterology, Hepatology and Endoscopy Practice.2023; 3(4): 127.     CrossRef
  • Advancements in the Management of Moderate-to-Severe Ulcerative Colitis: A Revised 2023 Korean Treatment Guidelines
    Soo-Young Na
    The Korean Journal of Medicine.2023; 98(5): 223.     CrossRef
  • Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study
    Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, Chang Hwan Choi
    Gut and Liver.2022; 16(5): 764.     CrossRef
  • Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo
    Alexander Keith Turbayne, Miles Patrick Sparrow
    Digestive Diseases and Sciences.2022; 67(12): 5382.     CrossRef
  • Identifying Care Challenges as Opportunities for Research and Education in Inflammatory Bowel Disease in South Asia
    Madhura Balasubramaniam, Neilanjan Nandi, Tina Aswani-Omprakash, Shaji Sebastian, Vishal Sharma, Parakkal Deepak, Shrinivas Bishu, Neha D. Shah, Sumit Bhatia, Tauseef Ali, Sharan Khela, Kiran Peddi
    Gastroenterology.2022; 163(5): 1145.     CrossRef
  • Physician education can minimize inappropriate steroid use in patients with inflammatory bowel disease: the ACTION study
    Yehyun Park, Chang Hwan Choi, Hyun Soo Kim, Hee Seok Moon, Do Hyun Kim, Jin Ju Kim, Dennis Teng, Dong Il Park
    Intestinal Research.2022; 20(4): 452.     CrossRef
  • Identifying Care Challenges as Opportunities for Research and Education in Inflammatory Bowel Disease in South Asia
    Madhura Balasubramaniam, Neilanjan Nandi, Tina Aswani-Omprakash, Shaji Sebastian, Vishal Sharma, Parakkal Deepak, Shrinivas Bishu, Neha D. Shah, Sumit Bhatia, Tauseef Ali, Sharan Khela, Kiran Peddi
    Clinical Gastroenterology and Hepatology.2022; 20(11): 2421.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • 6,644 View
  • 443 Download
  • 7 Web of Science
  • 9 Crossref
Close layer
Inflammatory Bowel Diseases
High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis
Saransh Jain, Divya Namdeo, Pabitra Sahu, Saurabh Kedia, Peush Sahni, Prasenjit Das, Raju Sharma, Vipin Gupta, Govind Makharia, Lalit Dar, Simon PL Travis, Vineet Ahuja
Intest Res 2021;19(4):438-447.   Published online November 6, 2020
DOI: https://doi.org/10.5217/ir.2020.00055
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Predictors of short-term outcome of intravenous (IV) steroid therapy in acute severe ulcerative colitis (ASUC) have been well described, but the impact of cytomegalovirus (CMV) infection as a predictor of outcome remains debatable. We investigated the role of quantitative CMV polymerase chain reaction (PCR) as a predictor of short-term outcome in patients with ASUC.
Methods
Consecutive patients with ASUC satisfying Truelove and Witts criteria hospitalized at All India Institute of Medical Sciences (AIIMS) from May 2016 to July 2019 were included; all received IV steroid. The primary outcome measure was steroid-failure defined as the need for rescue therapy (with ciclosporin or infliximab) or colectomy during admission. AIIMS’ index (ulcerative colitis index of severity > 6 at day 1+fecal calprotectin > 1,000 μg/g at day 3), with quantitative CMV PCR on biopsy samples obtained at initial sigmoidoscopy were correlated with the primary outcome.
Results
Thirty of 76 patients (39%) failed IV corticosteroids and 12 (16%) underwent surgery. Patients with steroid failure had a significantly higher mucosal CMV DNA than responders (3,454 copies/mg [0–2,700,000] vs. 116 copies/mg [0–27,220]; P< 0.01). On multivariable analysis, mucosal CMV DNA load > 2,000 copies/mg (odds ratio [OR], 10.2; 95% confidence interval [CI], 2.6–39.7; P< 0.01) and AIIMS’ index (OR, 39.8; 95% CI, 4.4–364.4; P< 0.01) were independent predictors of steroid-failure and need for colectomy. The combination correctly predicted outcomes in 84% of patients with ASUC.
Conclusions
High mucosal CMV DNA ( > 2,000 copies/mg) independently predicts failure of IV corticosteroids and short-term risk of colectomy and it has an additional value to the established markers of disease severity in patients with ASUC.

Citations

Citations to this article as recorded by  
  • Predictors of adverse outcomes of steroids in patients with severe ulcerative colitis (systematic review and meta-analyses)
    A. F. Mingazov, O. I. Sushkov, B. R. Kalanov, T. A. Baranova, S. I. Achkasov
    Koloproktologia.2024; 23(1): 172.     CrossRef
  • Predicting Outcome after Acute Severe Ulcerative Colitis: A Contemporary Review and Areas for Future Research
    Sudheer Kumar Vuyyuru, Olga Maria Nardone, Vipul Jairath
    Journal of Clinical Medicine.2024; 13(15): 4509.     CrossRef
  • Low prevalence of Clostridioides difficile infection in acute severe ulcerative colitis: A retrospective cohort study from northern India
    Sandeep Mundhra, David Thomas, Saransh Jain, Pabitra Sahu, Sudheer Vuyyuru, Peeyush Kumar, Bhaskar Kante, Rajesh Panwar, Peush Sahni, Rama Chaudhry, Prasenjit Das, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Indian Journal of Gastroenterology.2023; 42(3): 411.     CrossRef
  • Systematic Review: Outcome Prediction in Acute Severe Ulcerative Colitis
    Julia Angkeow, Alissa Rothman, Lara Chaaban, Nicole Paul, Joanna Melia
    Gastro Hep Advances.2023;[Epub]     CrossRef
  • The role of cytomegalovirus colitis on short- and long-term outcomes for patients with ulcerative colitis
    Mengmeng Zhang, Xiaoyin Bai, Huimin Zhang, Yan You, Hong Lv, Yue Li, Bei Tan, Ji Li, Hui Xu, Weiyang Zheng, Hong Yang, Jiaming Qian
    Scandinavian Journal of Gastroenterology.2022; 57(3): 282.     CrossRef
  • Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment
    Anuraag Jena, Shubhra Mishra, Anupam Kumar Singh, Aravind Sekar, Vishal Sharma
    Expert Review of Gastroenterology & Hepatology.2022; 16(2): 109.     CrossRef
  • Prospective validation of AIIMS index as a predictor of steroid failure in patients with acute severe ulcerative colitis
    Pabitra Sahu, Saransh Jain, Saurabh Kedia, Sudheer K. Vuyyuru, Peush Sahni, Raju Sharma, Rajesh Panwar, Prasenjit Das, Vipin Gupta, Govind Makharia, Simon Travis, Vineet Ahuja
    Indian Journal of Gastroenterology.2022; 41(3): 273.     CrossRef
  • Cytomegalovirus Infection in Patients with Inflammatory Bowel Disease
    Jun Lee
    The Korean Journal of Gastroenterology.2022; 80(2): 60.     CrossRef
  • The Impact of Human Herpesviruses in Clinical Practice of Inflammatory Bowel Disease in the Era of COVID-19
    Shuhei Hosomi, Yu Nishida, Yasuhiro Fujiwara
    Microorganisms.2021; 9(9): 1870.     CrossRef
  • Does cytomegalovirus load predict the outcome of acute severe ulcerative colitis?
    You Sun Kim
    Intestinal Research.2021; 19(4): 357.     CrossRef
  • 5,680 View
  • 210 Download
  • 8 Web of Science
  • 10 Crossref
Close layer
Review
Inflammatory bowel diseases
Colitis and Crohn’s Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease
Ajit Sood, Vineet Ahuja, Vandana Midha, Saroj Kant Sinha, C. Ganesh Pai, Saurabh Kedia, Varun Mehta, Sawan Bopanna, Philip Abraham, Rupa Banerjee, Shobna Bhatia, Karmabir Chakravartty, Sunil Dadhich, Devendra Desai, Manisha Dwivedi, Bhabhadev Goswami, Kirandeep Kaur, Rajeev Khosla, Ajay Kumar, Ramit Mahajan, S. P. Misra, Kiran Peddi, Shivaram Prasad Singh, Arshdeep Singh
Intest Res 2020;18(4):355-378.   Published online July 13, 2020
DOI: https://doi.org/10.5217/ir.2019.09176
AbstractAbstract PDFPubReaderePub
Despite several recent advances in therapy in inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) therapy has retained its place especially in ulcerative colitis. This consensus on 5-ASA is obtained through a modified Delphi process, and includes guiding statements and recommendations based on literature evidence (randomized trials, and observational studies), clinical practice, and expert opinion on use of 5-ASA in IBD by Indian gastroenterologists. The aim is to aid practitioners in selecting appropriate treatment strategies and facilitate optimal use of 5-ASA in patients with IBD.

Citations

Citations to this article as recorded by  
  • Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis
    Arshdeep Singh, Ramit Mahajan, Vandana Midha, Kirandeep Kaur, Dharmatma Singh, Ramandeep Kaur, Shreya Garg, Kirti Arora, Namita Bansal, Ajit Sood
    Digestive Diseases and Sciences.2024; 69(4): 1389.     CrossRef
  • The impact of 5-aminosalicylates on the efficacy of mesenchymal stem cell therapy in a murine model of ulcerative colitis
    Huanhuan Chen, Huimin Wang, XiaoJing Xu, Ya'nan Hu, Jing Su, Dongdong Li, Zimu Li, Shixiang Feng, Jinming Liu, Huanxiang Zhang, Xiaoyan Wang
    International Immunopharmacology.2024; 134: 112255.     CrossRef
  • The impact of clinical experience on decision-making regarding the treatment and management of mild-to-moderate ulcerative colitis
    Jae Hee Cheon, Kristine Paridaens, Sameer Al Awadhi, Jakob Begun, John R Fullarton, Edouard Louis, Fernando Magro, Juan Ricardo Marquez, Alexander R Moschen, Neeraj Narula, Grazyna Rydzewska, Axel U Dignass, Simon PL Travis
    Intestinal Research.2023; 21(1): 161.     CrossRef
  • Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination for Colon-Specific Drug Delivery
    Eman J. Heikal, Rashad M. Kaoud, Shadeed Gad, Hatem I. Mokhtar, Abdullah Alattar, Reem Alshaman, Sawsan A. Zaitone, Yasser M. Moustafa, Taha M. Hammady
    Gels.2023; 9(4): 264.     CrossRef
  • Consenso colombiano de la enfermedad inflamatoria intestinal pediátrica
    José Fernando Vera Chamorro, Claudia Sánchez Franco, Melquicedec Vargas Sandoval, Diana Victoria Mora Quintero, Juan Pablo Riveros López, Fernando Sarmiento Quintero, Catalina Ortiz-Piedrahita, Otto Gerardo Calderón-Guerrero, Hugo Laignelet, Claudia Lili
    Revista colombiana de Gastroenterología.2023; 38(Supl No. 1): 1.     CrossRef
  • Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Jong Pil Im, Hyunju Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Joo Sung Kim, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Journal of Crohn's and Colitis.2022; 16(2): 207.     CrossRef
  • Serum inter-alpha-trypsin inhibitor heavy chain 4 in patients with inflammatory bowel disease: correlation with disease risk, inflammation, activity, and its variation after treatment
    Nuan Wen, Na Zhao, Huixian Xu, Ying Zhao, Jian Ma
    Irish Journal of Medical Science (1971 -).2022; 191(5): 2105.     CrossRef
  • 5-Aminosalicylic Acid-induced Myocarditis in a Patient with Atypical Ulcerative Colitis
    Hyo Yeop Song, Geom Seog Seo
    The Korean Journal of Gastroenterology.2022; 79(1): 31.     CrossRef
  • The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis
    Eun Ae Kang
    Gut and Liver.2022; 16(3): 487.     CrossRef
  • Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
    Jihye Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2022; 37(5): 895.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • 9,233 View
  • 313 Download
  • 13 Web of Science
  • 13 Crossref
Close layer
Original Articles
Inflammatory Bowel Diseases
Efficacy and tolerability of exclusive enteral nutrition in adult patients with complicated Crohn’s disease
Sanchit Sharma, Arti Gupta, Saurabh Kedia, Samagra Agarwal, Namrata Singh, Sandeep Goyal, Saransh Jain, Vipin Gupta, Pabitra Sahu, Sudheer Kumar Vuyyuru, Bhaskar Kante, Raju Sharma, Rajesh Panwar, Peush Sahni, Govind Makharia, Vineet Ahuja
Intest Res 2021;19(3):291-300.   Published online May 26, 2020
DOI: https://doi.org/10.5217/ir.2019.09172
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Exclusive enteral nutrition (EEN), an established modality for pediatric Crohn’s disease (CD) is seldomly utilized in adults. The present study reports the outcome of EEN in adult CD patients at a tertiary care hospital in India.
Methods
This was a retrospective analysis of CD patients who received EEN as a sole modality/adjunct to other treatment. The primary and secondary outcomes changed in Crohn’s Disease Activity Index (CDAI), and clinical response (decline in CDAI > 70), respectively, at 4 and 8 weeks. Subgroup analysis evaluated response across different phenotypes, EEN formulations and prior treatment. Linear mixed effect model was created to assess the predictors of EEN response.
Results
Thirty-one CD patients received EEN over median duration of 4 weeks (range, 2–6 weeks). CDAI showed a significant improvement post EEN at 4 (baseline 290 [260–320] vs. 240 [180–280], P= 0.001) and 8 weeks (baseline 290 [260–320] vs. 186 [160–240], P= 0.001), respectively. The cumulative clinical response rates at 4 and 8 weeks were 37.3% and 80.4% respectively. The clinical response rates at 8 weeks across B1 (n = 4), B2 (n = 18) and B3 (n = 9) phenotypes were 50%, 78.8% and 100% respectively (log-rank test, P= 0.093). The response rates at 8 weeks with polymeric (n = 8) and semi-elemental diet (n = 23) were 75% and 82.6%% respectively (log-rank test, P= 0.49). Baseline CDAI (odds ratio, 1.008; 95% confidence interval, 1.002–1.017; P= 0.046) predicted response to EEN.
Conclusions
EEN was effective in inducing clinical response across different phenotypes of CD. Baseline disease activity remained the most important predictor of clinical response to EEN.

Citations

Citations to this article as recorded by  
  • Progress and Clinical Applications of Crohn’s Disease Exclusion Diet in Crohn’s Disease
    Duo Xu, Ziheng Peng, Yong Li, Qian Hou, Yu Peng, Xiaowei Liu
    Gut and Liver.2024; 18(3): 404.     CrossRef
  • Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) (Version 4.1) – living guideline
    Andreas Sturm, Raja Atreya, Dominik Bettenworth, Bernd Bokemeyer, Axel Dignass, Robert Ehehalt, Christoph-Thomas Germer, P. C. Grunert, Ulf Helwig, Karoline Horisberger, Klaus Herrlinger, Peter Kienle, Torsten Kucharzik, Jost Langhorst, Christian Maaser,
    Zeitschrift für Gastroenterologie.2024; 62(08): 1229.     CrossRef
  • Use of oral diet and nutrition support in management of stricturing and fistulizing Crohn's disease
    Kush Fansiwala, Neha D. Shah, Kelly A. McNulty, Mary R. Kwaan, Berkeley N. Limketkai
    Nutrition in Clinical Practice.2023; 38(6): 1282.     CrossRef
  • Exclusive Enteral Nutrition Orchestrates Immunological Balances as Early as Week 4 in Adult Patients of Crohn’s Disease: A Pilot, Open-Lable Study
    Na Diao, Xinyu Liu, Minzhi Lin, Qingfan Yang, Bingyang Li, Jian Tang, Ni Ding, Xiang Gao, Kang Chao
    Nutrients.2023; 15(24): 5091.     CrossRef
  • Exclusive enteral nutrition with oral polymeric diet helps in inducing clinical and biochemical remission in adults with active Crohn's disease
    Pradeep Kakkadasam Ramaswamy
    Journal of Parenteral and Enteral Nutrition.2022; 46(2): 423.     CrossRef
  • Is the frequency of dietitian support associated with greater clinical improvements in adults with Crohn's disease undertaking exclusive enteral nutrition?
    Liz Purcell, Rumbidzai Mutsekwa, Rebecca Angus, Dheeraj Shukla, Michelle Palmer
    Journal of Human Nutrition and Dietetics.2022; 35(3): 435.     CrossRef
  • Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004
    Andreas Sturm, Raja Atreya, Dominik Bettenworth, Bernd Bokemeyer, Axel Dignaß, Robert Ehehalt, Christoph Germer, Philip C. Grunert, Ulf Helwig, Klaus Herrlinger, Peter Kienle, Martin E. Kreis, Torsten Kucharzik, Jost Langhorst, Christian Maaser, Johann Oc
    Zeitschrift für Gastroenterologie.2022; 60(03): 332.     CrossRef
  • Diet and nutrition in the management of inflammatory bowel disease
    Pabitra Sahu, Saurabh Kedia, Vineet Ahuja, Rakesh K. Tandon
    Indian Journal of Gastroenterology.2021; 40(3): 253.     CrossRef
  • Review of exclusive enteral therapy in adult Crohn’s disease
    Nikola Mitrev, Hin Huang, Barbara Hannah, Viraj Chandana Kariyawasam
    BMJ Open Gastroenterology.2021; 8(1): e000745.     CrossRef
  • Current Use of EEN in Pre-Operative Optimisation in Crohn’s Disease
    Sharafaath Shariff, Gordon Moran, Caris Grimes, Rachel Margaret Cooney
    Nutrients.2021; 13(12): 4389.     CrossRef
  • Exclusive Enteral Nutrition in Adult Crohn’s Disease: an Overview of Clinical Practice and Perceived Barriers
    Roberto de Sire, Olga Maria Nardone, Anna Testa, Giulio Calabrese, Anna Caiazzo, Fabiana Castiglione
    Clinical and Experimental Gastroenterology.2021; Volume 14: 493.     CrossRef
  • Making Decisions about Dietary Therapy in Inflammatory Bowel Disease
    Sydney Solomon, Eunie Park, Joseph A. Picoraro
    Gastrointestinal Disorders.2020; 2(4): 353.     CrossRef
  • EEN Yesterday and Today … CDED Today and Tomorrow
    Marta Herrador-López, Rafael Martín-Masot, Víctor Manuel Navas-López
    Nutrients.2020; 12(12): 3793.     CrossRef
  • 6,462 View
  • 295 Download
  • 13 Web of Science
  • 13 Crossref
Close layer
Inflammatory Bowel Diseases
Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease
Ritika Rampal, Saurabh Kedia, Mohamad Nahidul Wari, Deepak Madhu, Amit Kumar Singh, Veena Tiwari, V. Pratap Mouli, Srikant Mohta, Govind Makharia, Vineet Ahuja
Intest Res 2021;19(2):232-238.   Published online May 8, 2020
DOI: https://doi.org/10.5217/ir.2019.09181
AbstractAbstract PDFPubReaderePub
Background/Aims
Crohn’s disease (CD) and intestinal tuberculosis (ITB) remain “difficult-to-differentiate” diseases. We have previously documented peripheral blood frequency of CD4+CD25+FOXP3+ T-regulatory cells (Treg) as a biomarker to differentiate CD and ITB. We tried to validate these results in a larger cohort of CD and ITB patients.
Methods
Seventy treatment naïve patients of CD (n = 23) and ITB (n = 47) (diagnosed by standard criteria) were recruited prospectively from October 2016 to May 2017. Patients with history of antitubercular therapy in the past were excluded. The frequency of Treg cells in peripheral blood was determined by flow cytometry, and compared between CD and ITB patients.
Results
Similar to our previous study, frequency of Treg cells in peripheral blood was significantly increased in ITB as compared to CD patients (40.9 [interquartile range, 33–50] vs. 24.9 [interquartile range, 14.4–29.6], P< 0.001). Further, the receiver operating characteristics curve also showed good diagnostic accuracy with an area under the curve (AUC) of 0.77 (95% confidence interval, 0.65–0.89) and a FOXP3+ cutoff value of > 31.3% had a sensitivity and specificity of 83% and 82.6% respectively, to differentiate ITB from CD. Even for the indeterminate cases (n = 33), Treg cell frequency had similar diagnostic accuracy with an AUC of 0.85 (95% confidence interval, 0.68–0.95) and a cutoff of 32.37% had sensitivity and specificity of 87% and 95% respectively, to differentiate ITB from CD.
Conclusions
The current findings validate that the increased frequency of CD4+CD25+FOXP3+ Treg in the peripheral blood can be used as a biomarker with high diagnostic accuracy to differentiate ITB from CD.

Citations

Citations to this article as recorded by  
  • New diagnostic strategies to distinguish Crohn's disease and gastrointestinal tuberculosis
    Himanshu Narang, Saurabh Kedia, Vineet Ahuja
    Current Opinion in Infectious Diseases.2024; 37(5): 392.     CrossRef
  • Evidence-based approach to diagnosis and management of abdominal tuberculosis
    Daya Krishna Jha, Mythili Menon Pathiyil, Vishal Sharma
    Indian Journal of Gastroenterology.2023; 42(1): 17.     CrossRef
  • Gut Microbiome in Probable Intestinal Tuberculosis and Changes following Anti-Tuberculosis Treatment
    Hyuk Yoon, Young Soo Park, Cheol Min Shin, Nayoung Kim, Dong Ho Lee
    Yonsei Medical Journal.2022; 63(1): 34.     CrossRef
  • Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients
    Tingming Cao, Guangming Dai, Hongqian Chu, Chengcheng Kong, Huijuan Duan, Na Tian, Zhaogang Sun
    Hereditas.2022;[Epub]     CrossRef
  • Recent advances in the diagnosis of intestinal tuberculosis
    Hasan Maulahela, Marcellus Simadibrata, Erni Juwita Nelwan, Nur Rahadiani, Editha Renesteen, S. W. T. Suwarti, Yunita Windi Anggraini
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis
    Saurabh Kedia, Raju Sharma, Sudheer Kumar Vuyyuru, Deepak Madhu, Pabitra Sahu, Bhaskar Kante, Prasenjit Das, Ankur Goyal, Karan Madan, Govind Makharia, Vineet Ahuja
    Intestinal Research.2022; 20(2): 184.     CrossRef
  • Inflammatory bowel disease in Korea: epidemiology and pathophysiology
    Jung Won Lee, Chang Soo Eun
    The Korean Journal of Internal Medicine.2022; 37(5): 885.     CrossRef
  • Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2021; 5(2): 177.     CrossRef
  • Deep‐learning system for real‐time differentiation between Crohn's disease, intestinal Behçet's disease, and intestinal tuberculosis
    Jung Min Kim, Jun Gu Kang, Sungwon Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2021; 36(8): 2141.     CrossRef
  • Mycobacterium tuberculosis (MTB) antigen-induced upregulation of interleukin-35 expression in patients with MTB infection: In vitro blockade of the effects of interleukin-35 on T lymphocyte subsets
    Hongbin Jiang, Beinian Cui, Jun Zhang
    Pathogens and Disease.2021;[Epub]     CrossRef
  • 5,874 View
  • 131 Download
  • 8 Web of Science
  • 10 Crossref
Close layer
Miscellaneous
Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver
Ashish Agarwal, Alka Singh, Wajiha Mehtab, Vipin Gupta, Ashish Chauhan, Mahendra Singh Rajput, Namrata Singh, Vineet Ahuja, Govind K. Makharia
Intest Res 2021;19(1):106-114.   Published online April 22, 2020
DOI: https://doi.org/10.5217/ir.2019.00136
AbstractAbstract PDFPubReaderePub
Background/Aims
Gluten-free diet has an excess of fats and simple sugars and puts patients with celiac disease at risk of metabolic complications including metabolic syndrome and fatty liver. We assessed prevalence of metabolic syndrome and fatty liver in two cohorts of celiac disease.
Methods
Study was done in 2 groups. In group 1, 54 treatment naïve patients with celiac disease were recruited. Of them, 44 returned after 1-year of gluten-free diet and were reassessed. In group 2, 130 celiac disease patients on gluten-free diet for ≥1 year were recruited. All patients were assessed for anthropometric and metabolic parameters and fatty liver. Metabolic syndrome was defined as per consensus definition for Asian Indians. Fatty liver was defined as controlled attenuation parameter value >263 decibels by FibroScan.
Results
In group 1, of 44 treatment naïve patients with celiac disease, metabolic syndrome was present in 5 patients (11.4%) at baseline and 9 (18.2%) after 1 year of gluten-free diet. Patients having fatty liver increased from 6 patients (14.3%) at baseline to 13 (29.5%) after 1year of gluten-free diet (P=0.002). In group 2, of 130 patients with celiac disease on gluten-free diet for a median duration of 4 years, 30 out of 114 (26.3%) and 30 out of 130 patients (23%) had metabolic syndrome and fatty liver, respectively.
Conclusions
Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver, which increases further with gluten-free diet. These patients should be assessed for nutritional and metabolic features and counseled about balanced diet and physical activity regularly.

Citations

Citations to this article as recorded by  
  • Efficacy of Antiobesity Medications in Patients With Celiac Disease on a Gluten-free Diet
    Diego Anazco, Sima Fansa, Wissam Ghusn, Khushboo Gala, Bryan Nicolalde, Elif Tama, Gerardo Calderon, Adam C. Bledsoe, Maria D. Hurtado, Joseph A. Murray, Andres Acosta
    Journal of Clinical Gastroenterology.2024; 58(7): 650.     CrossRef
  • Guidelines for best practices in monitoring established coeliac disease in adult patients
    Luca Elli, Daniel Leffler, Christophe Cellier, Benjamin Lebwohl, Carolina Ciacci, Michael Schumann, Knut E. A. Lundin, Stefania Chetcuti Zammit, Reena Sidhu, Leda Roncoroni, Julio C. Bai, Anne R. Lee, Melinda Dennis, Marie E. Robert, Kamran Rostami, Sheri
    Nature Reviews Gastroenterology & Hepatology.2024; 21(3): 198.     CrossRef
  • Probiotic Interventions in Coeliac Disease: A Systematic Review with a Focus on Cardiovascular Risk
    Lorretta Olu Fagbemi, Carlo Soldaini, Adele Costabile, Sofia Kolida, Carolina Ciacci, Yvonne Jeanes
    Gastrointestinal Disorders.2024; 6(1): 114.     CrossRef
  • Metabolomics and lipidomics signature in celiac disease: a narrative review
    Mohammad Rostami-Nejad, Nastaran Asri, Sajjad Bakhtiari, Ensieh Khalkhal, Sepehr Maleki, Mostafa Rezaei-Tavirani, Somayeh Jahani-Sherafat, Kamran Rostami
    Clinical and Experimental Medicine.2024;[Epub]     CrossRef
  • Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study
    Shuai Yuan, Dan Leffler, Benjamin Lebwohl, Peter H. R. Green, Jiangwei Sun, Sofia Carlsson, Susanna C. Larsson, Jonas F. Ludvigsson
    Diabetologia.2024; 67(8): 1630.     CrossRef
  • Neither hepatic steatosis nor fibrosis is associated with clinical outcomes in patients with intestinal Behçet’s disease
    Hye Kyung Hyun, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
    European Journal of Gastroenterology & Hepatology.2024; 36(4): 445.     CrossRef
  • The Impact of a Gluten-Free Diet on Pregnant Women with Celiac Disease: Do We Need a Guideline to Manage Their Health?
    Yeliz Serin, Camilla Manini, Pasqualino Amato, Anil K. Verma
    Gastrointestinal Disorders.2024; 6(3): 675.     CrossRef
  • The Effects of Gluten-free Diet on Body Mass Indexes in Adults with Celiac Disease
    Noam Peleg, Yaron Niv, Ram Dickman, Doron Boltin, Alex Krauthammer, Michal Herman-Edelstein, Nidal Issa, Jacob E. Ollech, Tom Konikoff, Rachel Gingold-Belfer
    Journal of Clinical Gastroenterology.2024;[Epub]     CrossRef
  • Nutrition Assessment and Management in Celiac Disease
    M. Ines Pinto-Sanchez, Jedid-Jah Blom, Peter R. Gibson, David Armstrong
    Gastroenterology.2024;[Epub]     CrossRef
  • Celiac disease - a pluripathological model in pediatric practice
    Vasile Valeriu Lupu, Maria Oana Sasaran, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Adriana Mocanu, Solange Tamara Rosu, Valentin Munteanu, Alin Horatiu Nedelcu, Ciprian Danielescu, Delia Lidia Salaru, Anton Knieling, Ancuta Lupu
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Patients with Celiac Disease Have High Prevalence of Fatty Liver and Metabolic Syndrome
    Nishant Aggarwal, Ashish Agarwal, Hasan Alarouri, Vignesh Dwarakanathan, Sana Dang, Vineet Ahuja, Govind K. Makharia
    Digestive Diseases and Sciences.2024; 69(8): 3029.     CrossRef
  • Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage
    Jocelyn A. Silvester, Luca Elli, Chaitan Khosla, Jason A. Tye-Din
    Gastroenterology.2024; 167(1): 159.     CrossRef
  • The Economic Iceberg of Celiac Disease: More Than the Cost of Gluten-Free Food
    Soran R. Bozorg, Anne R. Lee, Karl Mårild, Joseph A. Murray
    Gastroenterology.2024;[Epub]     CrossRef
  • Gluten-free foods are expensive and nutritionally imbalanced than their gluten-containing counterparts
    Wajiha Mehtab, Samagra Agarwal, Harsh Agarwal, Anam Ahmed, Ashish Agarwal, Shubham Prasad, Ashish Chauhan, Anjali Bhola, Namrata Singh, Vineet Ahuja, Anita Malhotra, Govind K Makharia
    Indian Journal of Gastroenterology.2024; 43(3): 668.     CrossRef
  • Letter: Breaking new ground—Understanding the role of ATI‐free diet in managing MASLD
    Matteo Spertino, Rossi Roberta Elisa, Nicola Pugliese
    Alimentary Pharmacology & Therapeutics.2024; 60(2): 302.     CrossRef
  • Celiac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease
    Georgiana-Diana Cazac, Bogdan-Mircea Mihai, Gabriela Ștefănescu, Georgiana-Emmanuela Gîlcă-Blanariu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Cristina-Mihaela Lăcătușu
    Nutrients.2024; 16(13): 2008.     CrossRef
  • Gluten-Free Diet—What’s Good for Celiac Disease Can Be Bad for Metabolism
    Kathleen Viveiros, Sonal Kumar
    Digestive Diseases and Sciences.2024; 69(8): 2721.     CrossRef
  • Gluten: do only celiac patients benefit from its removal from the diet?
    Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flávio Eduardo Dias Araújo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitória Cota de Abreu, Janaina Koenen Fonseca, Renato Guimarães
    Food Reviews International.2023; 39(7): 4388.     CrossRef
  • Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis
    Michele Barone, Andrea Iannone, Fernanda Cristofori, Vanessa Nadia Dargenio, Flavia Indrio, Elvira Verduci, Alfredo Di Leo, Ruggiero Francavilla
    Nutrition Reviews.2023; 81(3): 252.     CrossRef
  • Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine
    Mihaela Simona Popoviciu, Nirja Kaka, Yashendra Sethi, Neil Patel, Hitesh Chopra, Simona Cavalu
    Journal of Personalized Medicine.2023; 13(3): 422.     CrossRef
  • Celiac Disease and Cardiovascular Risk: A Retrospective Case-Control Study
    Maria Pina Dore, Sandro Mereu, Pier Sergio Saba, Michele Portoghese, Giovanni Mario Pes
    Journal of Clinical Medicine.2023; 12(6): 2087.     CrossRef
  • Nutritional status, nutrient imbalances, food-related behaviors and dietary supplements use among patients with celiac disease on a gluten free diet in Lebanon: a national cross-sectional study
    Maha Hoteit, Zeinab Chamas, Shaza Assaf, Malek Michael Bouhairie, Abbas Bahr, Romy Daccache, Rami Matar, Mahmoud Hallal, Samer Hotayt, Bilal Hotayt
    F1000Research.2023; 11: 725.     CrossRef
  • Fatty liver and celiac disease: Why worry?
    Janaina Luz Narciso-Schiavon, Leonardo Lucca Schiavon
    World Journal of Hepatology.2023; 15(5): 666.     CrossRef
  • Prevalence of autoimmune, cholestatic and nonalcoholic fatty liver disease in celiac disease
    Asif Ali Hitawala, Ashraf Almomani, Somtochukwu Onwuzo, Antoine Boustany, Prabhat Kumar, Imad Asaad
    European Journal of Gastroenterology & Hepatology.2023; 35(9): 1030.     CrossRef
  • Body Mass Index during Gluten-Free Diet in Patients with Celiac Disease
    Zsófia Vereczkei, Tímea Dergez, Zsuzsanna Fodor, Zsolt Szakács, Judit Bajor
    Nutrients.2023; 15(16): 3517.     CrossRef
  • Obesity and Colorectal Cancer
    Jundeok Lee, Su Young Kim
    The Korean Journal of Gastroenterology.2023; 82(2): 63.     CrossRef
  • Incidentally Discovered Cryptogenic Cirrhosis in a Patient with Untreated Celiac Disease
    Kelli Kosako Yost, Yasmin Alishahi
    Galician Medical Journal.2023; 30(3): E202336.     CrossRef
  • The association of interleukin-10 single nucleotide polymorphisms (rs1800871) and serum levels in Iraqi patients with celiac disease: A case-control study
    Ali Hafedh Abbas, Sahar Taha Hatif, Faiq Isho Gorial, Sara Bayan Ali
    Clinical Epidemiology and Global Health.2023; 24: 101437.     CrossRef
  • Unveiling the Link: A Comprehensive Narrative Review of the Relationship Between Type 1 Diabetes Mellitus and Celiac Disease
    Sanvi Arora, Ayush Tayade, Tanya Bhardwaj, Swanand S Pathak
    Cureus.2023;[Epub]     CrossRef
  • Prevalence of Non-alcoholic Fatty Liver Disease in India: A Systematic Review and Meta-analysis
    Shalimar, Anshuman Elhence, Bhavik Bansal, Hardik Gupta, Abhinav Anand, Thakur P. Singh, Amit Goel
    Journal of Clinical and Experimental Hepatology.2022; 12(3): 818.     CrossRef
  • Nutritional status, nutrient imbalances, food-related behaviors and dietary supplements use among patients with celiac disease in Lebanon: a national cross-sectional study
    Maha Hoteit, Zeinab Chamas, Shaza Assaf, Malek Michael Bouhairie, Abbas Bahr, Romy Daccache, Rami Matar, Marwa Hallal, Michael Maitar, Mahmoud Hallal, Samer Hotayt, Bilal Hotayt
    F1000Research.2022; 11: 725.     CrossRef
  • Eating Competence and Aspects Related to a Gluten-Free Diet in Brazilian Adults with Gluten-Related Disorders
    Pâmela Mayara de Oliveira, Renata Puppin Zandonadi, Amanda Moreira Veloso Cutrim, Eduardo Yoshio Nakano, Fabiana Lopes Nalon de Queiroz, Raquel B. A. Botelho, Ariana Saraiva, António Raposo
    Nutrients.2022; 14(14): 2815.     CrossRef
  • Nutritional status, nutrient imbalances, food-related behaviors and dietary supplements use among patients with celiac disease on a gluten free diet in Lebanon: a national cross-sectional study
    Maha Hoteit, Zeinab Chamas, Shaza Assaf, Malek Michael Bouhairie, Abbas Bahr, Romy Daccache, Rami Matar, Marwa Hallal, Mahmoud Hallal, Samer Hotayt, Bilal Hotayt
    F1000Research.2022; 11: 725.     CrossRef
  • Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review
    Martyna Marciniak, Aleksandra Szymczak-Tomczak, Dagmara Mahadea, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
    Nutrients.2021; 13(2): 643.     CrossRef
  • The Healthy Gluten-Free Diet: Practical Tips to Prevent Metabolic Disorders and Nutritional Deficiencies in Celiac Patients
    Emanuele Rinninella, Marco Cintoni, Pauline Raoul, Silvia Triarico, Tommaso Dionisi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Maria Cristina Mele
    Gastroenterology Insights.2021; 12(2): 166.     CrossRef
  • Nutritional Properties of Rice Varieties Commonly Consumed in Italy and Applicability in Gluten Free Diet
    Giorgia Vici, Diego Romano Perinelli, Dalia Camilletti, Flora Carotenuto, Luca Belli, Valeria Polzonetti
    Foods.2021; 10(6): 1375.     CrossRef
  • Physical development in children with celiac disease in St. Petersburg
    N. S. Shapovalova, V. P. Novikova, K. A. Klikunova
    Experimental and Clinical Gastroenterology.2021; (4): 116.     CrossRef
  • Celiac disease and obesity: the possibility of comboridity of pathology in children
    V. P. Novikova, V. L. Gritsinskaya, A. I. Khavkin
    Experimental and Clinical Gastroenterology.2021; (4): 124.     CrossRef
  • 10,947 View
  • 212 Download
  • 33 Web of Science
  • 38 Crossref
Close layer
Review
IBD
Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert WL Leong, the Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn’s and Colitis
Intest Res 2019;17(3):285-310.   Published online May 31, 2019
DOI: https://doi.org/10.5217/ir.2019.00026
AbstractAbstract PDFPubReaderePub
The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in collaboration with Asian Organization for Crohn’s and Colitis. With biologic agents and biosimilars becoming more established, it is necessary to conduct a review on existing literature and establish a consensus on when and how to introduce biologic agents and biosimilars in the conjunction with conventional treatments for ulcerative colitis (UC) and Crohn’s disease (CD) in Asia. These statements also address how pharmacogenetics influence the treatments of UC and CD and provide guidance on response monitoring and strategies to restore loss of response. Finally, the review includes statements on how to manage treatment alongside possible hepatitis B and tuberculosis infections, both common in Asia. These statements have been prepared and voted upon by members of IBD workgroup employing the modified Delphi process. These statements do not intend to be all-encompassing and future revisions are likely as new data continue to emerge.

Citations

Citations to this article as recorded by  
  • Progress on the mechanisms of Lactobacillus plantarum to improve intestinal barrier function in ulcerative colitis
    Yihui Liu, Gang Liu, Jun Fang
    The Journal of Nutritional Biochemistry.2024; 124: 109505.     CrossRef
  • Therapeutic Drug Monitoring in Patients with Systemic Lupus Erythematosus: Utility and Gaps
    Kar Mun Chong, He Jiang, Elaine Ah Gi Lo, Wei-Zhen Hong, Emmett Tsz-Yeung Wong, Gek Cher Chan, Jiacai Cho
    Journal of Clinical Medicine.2024; 13(2): 451.     CrossRef
  • Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway
    Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang, Muhammad Babar Khawar
    Journal of Food Quality.2024; 2024: 1.     CrossRef
  • Ten missteps in the management of inflammatory bowel disease in Asia: An expert report by the Asian Pacific Association of Gastroenterology Working Group on Inflammatory Bowel Disease
    Vineet Ahuja, Ida Hilmi, Byong Duk Ye, Khoon Lin Ling, Siew C. Ng, Rupert W. Leong, Peeyush Kumar, Xin Hui Khoo, Govind K. Makharia, Jose Sollano, Pises Pisespongsa, Nazri Mustaffa, Rupa Banerjee, Alex Hwong‐Ruey Leow, Raja Affendi Raja Ali, Sai Wei Chuah
    Journal of Gastroenterology and Hepatology.2024; 39(8): 1500.     CrossRef
  • Risk Factors of Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Jiyoung Yoon, Seung Wook Hong, Kyung-Do Han, Seung-Woo Lee, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim, Hyuk Yoon
    Gut and Liver.2024; 18(3): 489.     CrossRef
  • Modified Gegen Qinlian Decoction modulated the gut microbiome and bile acid metabolism and restored the function of goblet cells in a mouse model of ulcerative colitis
    Jinke Huang, Jiaqi Zhang, Fengyun Wang, Xudong Tang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Pharmacogenetics in personalized treatment in pediatric patients with inflammatory bowel disease (IBD)
    Daniela Kosorínová, Pavlína Suchá, Zuzana Havlíčeková, Marek Pršo, Pavol Dvoran, Peter Bánovčin
    Česko-slovenská pediatrie.2024; 79(4): 213.     CrossRef
  • Emerging Patterns of Inflammatory Bowel Disease in Sub-Saharan Africa: 175 Cases From an Inflammatory Bowel Disease Network
    Phoebe Hodges, Oluwafunmilayo Adeniyi, Smita Devani, Chinenye Nwoko, Opeyemi Owoseni, Kwadwo Gyebi Agyenim Boateng, Anthony Ocanit, Abdallah Muhofa, Nasiru Altine Dankiri, Babatunde Duduyemi, Zenahebezu Abay Alemayehu, Yusuf Musa, Eileen Micah, Pissi Kaba
    Journal of Crohn's and Colitis.2024;[Epub]     CrossRef
  • Real‐world experience of adalimumab therapy for patients with ulcerative colitis: A single tertiary medical center experience in Central Taiwan
    Hsu‐Heng Yen, Yu‐Chun Hsu, Chu‐Hsuan Kuo, Tsui‐Chun Hsu, Yang‐Yuan Chen
    Advances in Digestive Medicine.2023; 10(1): 28.     CrossRef
  • A Retrospective Cohort Study of Clinical Features and Treatment Patterns With Ustekinumab in Patients With Crohn Disease Utilizing a Health Care Database in Japan
    Yanfang Liu, Choo Hua Goh, Hong Qiu, Kuan-Chih Huang, Hsingwen Chung, Carine Saadoun
    Annals of Pharmacotherapy.2023; 57(9): 1053.     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • Optimización del tratamiento de la colitis ulcerosa leve a moderada: Consenso Delphi CU-Forum
    Miquel Sans Cuffi, Federico Argüelles Arias, Ana Echarri Piudo, Daniel Ginard Vicens, Ana Gutiérrez Casbas, Ignacio Marín-Jiménez
    Gastroenterología y Hepatología.2023; 46(10): 784.     CrossRef
  • Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo
    Songsong Jiang, Qian Li, Shiwen Han, Hengpeng Wang, Xinlei Tang, Tao Wang, Xiangren Meng
    Clinical and Experimental Pharmacology and Physiology.2023; 50(7): 573.     CrossRef
  • Physiologically‐Based Pharmacokinetic Modeling of Anti‐Tumor Necrosis Factor Agents for Inflammatory Bowel Disease Patients to Predict the Withdrawal Time in Pregnancy and Vaccine Time in Infants
    Jiarui Chen, Rongfang Lin, Guimu Guo, Wanhong Wu, Meng Ke, Chengjie Ke, Pinfang Huang, Cuihong Lin
    Clinical Pharmacology & Therapeutics.2023; 114(6): 1254.     CrossRef
  • Optimizing treatment of mild to moderate ulcerative colitis: CU-forum Delphi consensus
    Miquel Sans Cuffi, Federico Argüelles Arias, Ana Echarri Piudo, Daniel Ginard Vicens, Ana Gutiérrez Casbas, Ignacio Marín-Jiménez
    Gastroenterología y Hepatología (English Edition).2023; 46(10): 784.     CrossRef
  • Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
    Da-Yeon Kang, Jong-Lyul Park, Min-Kyung Yeo, Sang-Bum Kang, Jin-Man Kim, Ju Seok Kim, Seon-Young Kim
    BMC Microbiology.2023;[Epub]     CrossRef
  • IBD barriers across the continents – East Asia
    Joyce Wing Yan Mak, Agnes Hiu Yan Ho, Siew Chien Ng
    Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
  • Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Jong Pil Im, Hyunju Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Joo Sung Kim, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Journal of Crohn's and Colitis.2022; 16(2): 207.     CrossRef
  • Association between Fecal Calprotectin and Mucosal Healing in Pediatric Patients with Crohn’s Disease Who Have Achieved Sustained Clinical Remission with Anti-Tumor Necrosis Factor Agents
    Yoo Min Lee, Sujin Choi, Byung-Ho Choe, Hyo-Jeong Jang, Seung Kim, Hong Koh, Eun Sil Kim, Mi Jin Kim, Yon Ho Choe, Ben Kang
    Gut and Liver.2022; 16(1): 62.     CrossRef
  • Management of inflammatory bowel disease in the COVID-19 era
    Kyeong Ok Kim, Byung Ik Jang
    Intestinal Research.2022; 20(1): 3.     CrossRef
  • Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity
    Takato Maeda, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Yoichi Kakuta, Hidezumi Kikuchi, Shogo Kawaguchi, Keisuke Hasui, Tetsuya Tatsuta, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda
    Intestinal Research.2022; 20(1): 90.     CrossRef
  • Changes in the Long-term Prognosis of Crohn’s Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study
    Byong Duk Ye, Sung Noh Hong, Seung In Seo, Ye-Jee Kim, Jae Myung Cha, Kyoung Hoon Rhee, Hyuk Yoon, Young-Ho Kim, Kyung Ho Kim, Sun Yong Park, Seung Kyu Jeong, Ji Hyun Lee, Hyunju Park, Joo Sung Kim, Jong Pil Im, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim,
    Gut and Liver.2022; 16(2): 216.     CrossRef
  • Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South‐East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease‐Emerging Nations' Consortium
    Rupa Banerjee, Partha Pal, Ida Hilmi, Uday C Ghoshal, Devendra C Desai, Mohammed Masudur Rahman, Usha Dutta, Syed A Mohiuddin, Munnera Al Mohannadi, Mathew Philip, Ganesh N Ramesh, Madunil A Niriella, Arjuna P De Silva, Hithanadura Janaka de Silva, Pises
    Journal of Gastroenterology and Hepatology.2022; 37(6): 1004.     CrossRef
  • Implications of the COVID-19 Pandemic on the Management of Inflammatory Bowel Disease in the Low Resource Countries of Asia
    Partha Pal, Joyce Wing Yan Mak, Siew C Ng, Rupa Banerjee
    EMJ Gastroenterology.2022;[Epub]     CrossRef
  • The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis
    Eun Ae Kang
    Gut and Liver.2022; 16(3): 487.     CrossRef
  • Indications, Postoperative Management, and Long-term Prognosis of Crohn’s Disease After Ileocecal Resection: A Multicenter Study Comparing the East and West
    Jeanine H C Arkenbosch, Joyce W Y Mak, Jacky C L Ho, Evelien M J Beelen, Nicole S Erler, Frank Hoentjen, Alexander G L Bodelier, Gerard Dijkstra, Mariëlle Romberg-Camps, Nanne K H de Boer, Laurents P S Stassen, Andrea E van der Meulen, Rachel West, Oddeke
    Inflammatory Bowel Diseases.2022; 28(Supplement): S16.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Antiviral Prophylaxis Against Hepatitis B Virus in Patients Treated with Anti-Tumor Necrosis Factor α Agents for Inflammatory Bowel Disease
    Eun Ae Kang, Jae Hee Cheon
    Gut and Liver.2022; 16(4): 501.     CrossRef
  • Therapeutic Drug Monitoring of Biologics for Patients with Inflammatory Bowel Diseases: How, When, and for Whom?
    Jia-Feng Wu
    Gut and Liver.2022; 16(4): 515.     CrossRef
  • Risk of Hepatitis B Virus (HBV) Reactivation in Patients with Immune-Mediated Inflammatory Diseases Receiving Biologics: Focus on the Timing of Biologics after Anti-HBV Treatment
    Soo Min Ahn, Jonggi Choi, Byong Duk Ye, Suk-Kyun Yang, Ji Seon Oh, Yong‑Gil Kim, Chang-Keun Lee, Bin Yoo, Sang Hyoung Park, Seokchan Hong
    Gut and Liver.2022; 16(4): 567.     CrossRef
  • Oral beclomethasone dipropionate as an add-on therapy and response prediction in Korean patients with ulcerative colitis
    Kyuwon Kim, Hee Seung Hong, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(6): 1140.     CrossRef
  • Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study
    Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, Chang Hwan Choi
    Gut and Liver.2022; 16(5): 764.     CrossRef
  • Current Status of Opportunistic Infection in Inflammatory Bowel Disease Patients in Asia: A Questionnaire-Based Multicenter Study
    Hong Yang, Zhihua Ran, Meng Jin, Jia-Ming Qian
    Gut and Liver.2022; 16(5): 726.     CrossRef
  • Natural history of inflammatory bowel disease: a comparison between the East and the West
    Eun Mi Song, Suk-Kyun Yang
    Intestinal Research.2022; 20(4): 418.     CrossRef
  • Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
    Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Ge
    Gut and Liver.2022; 16(6): 907.     CrossRef
  • Early-Phase Partial Mayo Score following Golimumab Treatment Is Associated with Endoscopic Improvement at 1 Year in Ulcerative Colitis: A post hoc Analysis of PURSUIT-J Randomized Controlled Trial
    Katsumasa Nagano, Yuya Imai, Yoshifumi Ukyo, Taku Kobayashi, Seiji Yokoyama
    Inflammatory Intestinal Diseases.2022; 7(3-4): 155.     CrossRef
  • Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia
    Shu-Chen Wei, Jose Sollano, Yee Tak Hui, Wei Yu, Paul V. Santos Estrella, Lyndon John Q. Llamado, Nana Koram
    Expert Review of Gastroenterology & Hepatology.2021; 15(3): 275.     CrossRef
  • Mycosis fungoides in a patient with ulcerative colitis on anti-tumor necrosis factor-alpha therapy
    Takeshi Yasuda, Tomohisa Takagi, Jun Asai, Norito Katoh, Junya Kuroda, Yasumichi Kuwahara, Yukiko Morinaga, Eiichi Konishi, Kazuhiko Uchiyama, Yuji Naito, Yoshito Itoh
    Clinical Journal of Gastroenterology.2021; 14(1): 170.     CrossRef
  • Early Changes in Serum Albumin Predict Clinical and Endoscopic Outcomes in Patients With Ulcerative Colitis Starting Anti-TNF Treatment
    Sun-Ho Lee, Margaret Walshe, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Tomer Greener, Adam V Weizman, Mark S Silverberg, Byong Duk Ye
    Inflammatory Bowel Diseases.2021; 27(9): 1452.     CrossRef
  • Segundo Consenso Mexicano de terapia biológica y moléculas pequeñas en enfermedad inflamatoria intestinal
    J.K. Yamamoto-Furusho, F.J. Bosques-Padilla, M.A. Martínez-Vázquez
    Revista de Gastroenterología de México.2021; 86(1): 70.     CrossRef
  • Comparison of Long-term Outcomes of Infliximab versus Adalimumab in 1,488 Biologic-Naive Korean Patients with Crohn’s Disease
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    Gut and Liver.2021; 15(1): 92.     CrossRef
  • Clinical Outcomes and Response Predictors of Vedolizumab Induction Treatment for Korean Patients With Inflammatory Bowel Diseases Who Failed Anti-TNF Therapy: A KASID Prospective Multicenter Cohort Study
    Jeongseok Kim, Hyuk Yoon, Nayoung Kim, Kang-Moon Lee, Sung-Ae Jung, Chang Hwan Choi, Eun Soo Kim, Yunho Jung, Chang Soo Eun, Tae Oh Kim, Sang-Bum Kang, You Sun Kim, Geom-Seog Seo, Chang Kyun Lee, Jong Pil Im, Soo Jung Park, Dong Il Park, Byong Duk Ye
    Inflammatory Bowel Diseases.2021; 27(12): 1931.     CrossRef
  • Second Mexican consensus on biologic therapy and small-molecule inhibitors in inflammatory bowel disease
    J.K. Yamamoto-Furusho, F.J. Bosques-Padilla, M.A. Martínez-Vázquez
    Revista de Gastroenterología de México (English Edition).2021; 86(1): 70.     CrossRef
  • Early course of newly diagnosed moderate‐to‐severe ulcerative colitis in Korea: Results from a hospital‐based inception cohort study (MOSAIK)
    Jin Young Yoon, Jae Myung Cha, Chang Kyun Lee, Young Sook Park, Kyu Chan Huh, Jeong Eun Shin, You Sun Kim, Chang Soo Eun, Soon Man Yoon, Jae Hee Cheon, Young Soo Park, Byong Duk Ye, YoungJa Lee, Youngdoe Kim, Hyo Jong Kim
    Journal of Gastroenterology and Hepatology.2021; 36(8): 2149.     CrossRef
  • Role of Oxidative Stress and Inflammatory Cytokines (TNF-α and IL-6) in Acetic Acid-Induced Ulcerative Colitis in Rats: Ameliorated by Otostegia fruticosa
    Mohd Nazam Ansari, Najeeb Ur Rehman, Aman Karim, Gamal A. Soliman, Majid A. Ganaie, Mohammad Raish, Abubaker M. Hamad
    Life.2021; 11(3): 195.     CrossRef
  • Clinical features and treatment of inflammatory bowel disease in a low-incidence area
    Hsu-Heng Yen, Tsui-Chun Hsu, Mei-Wen Chen, Pei-Yuan Su, Yang-Yuan Chen
    Medicine.2021; 100(10): e25090.     CrossRef
  • Comparison of Long-Term Outcomes of Infliximab versus Adalimumab Treatment in Biologic-Naïve Patients with Ulcerative Colitis
    Yong Il Lee, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2021; 15(2): 232.     CrossRef
  • Enteroscopy in Crohn’s Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study
    Seong Ran Jeon, Jin-Oh Kim, Jeong-Sik Byeon, Dong-Hoon Yang, Bong Min Ko, Hyeon Jeong Goong, Hyun Joo Jang, Soo Jung Park, Eun Ran Kim, Sung Noh Hong, Jong Pil Im, Seong-Eun Kim, Ja Seol Koo, Chang Soo Eun, Dong Kyung Chang
    Gut and Liver.2021; 15(3): 375.     CrossRef
  • Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational stud
    Min Young Park, Yong Sik Yoon, Jong Lyul Lee, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Chang Sik Yu
    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
  • Efficacy and Safety of Fecal Microbiota Transplantation and Prospect of Microbe-based Therapies for Inflammatory Bowel Disease
    Hoon Gil Jo, Geom Seog Seo
    The Korean Journal of Gastroenterology.2021; 78(1): 31.     CrossRef
  • Differentiating between Intestinal Tuberculosis and Crohn’s Disease May Be Complicated by Multidrug-resistant Mycobacterium tuberculosis
    Seung Wook Hong, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang
    The Ewha Medical Journal.2021; 44(3): 93.     CrossRef
  • Short-term tolerability and effectiveness of methotrexate monotherapy in adult patients with Crohn’s disease: a retrospective study
    Hee Seung Hong, Kyuwon Kim, Kyunghwan Oh, Jae Yong Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Therapeutic Advances in Gastroenterology.2021;[Epub]     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on biologic agents and new therapies
    Hyo Yeop Song, Geom Seog Seo
    Journal of the Korean Medical Association.2021; 64(9): 605.     CrossRef
  • Treatment of inflammatory bowel diseases: focusing on 5-aminosalicylates and immunomodulators
    You Sun Kim
    Journal of the Korean Medical Association.2021; 64(9): 596.     CrossRef
  • Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
    Sang Hyoung Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Gut and Liver.2021; 15(5): 742.     CrossRef
  • Long-term Outcomes after the Discontinuation of Anti-Tumor Necrosis Factor-α Therapy in Patients with Inflammatory Bowel Disease under Clinical Remission: A Korean Association for the Study of Intestinal Disease Multicenter Study
    Joo Hye Song, Eun Ae Kang, Soo-Kyung Park, Sung Noh Hong, You Sun Kim, Ki Bae Bang, Kyeong Ok Kim, Hong Sub Lee, Sang-Bum Kang, Seung Yong Shin, Eun Mi Song, Jong Pil Im, Chang Hwan Choi
    Gut and Liver.2021; 15(5): 752.     CrossRef
  • Current status of inflammatory bowel diseases in Korea
    Suk-Kyun Yang
    Journal of the Korean Medical Association.2021; 64(9): 572.     CrossRef
  • Biosimilar-to-Biosimilar Switching: What is the Rationale and Current Experience?
    Eduardo Mysler, Valderilio Feijó Azevedo, Silvio Danese, Daniel Alvarez, Noriko Iikuni, Beverly Ingram, Markus Mueller, Laurent Peyrin-Biroulet
    Drugs.2021; 81(16): 1859.     CrossRef
  • Is Multidrug-resistant Extrapulmonary Tuberculosis Important? If So, What Is Our Strategy?
    Seong-Eun Kim
    The Ewha Medical Journal.2021; 44(4): 148.     CrossRef
  • Does cytomegalovirus load predict the outcome of acute severe ulcerative colitis?
    You Sun Kim
    Intestinal Research.2021; 19(4): 357.     CrossRef
  • Another Piece of Evidence for Early Administration of Biologics in Children with Crohn's Disease Who Start as an Inflammatory Phenotype
    Hyuk Yoon
    Gut and Liver.2021; 15(6): 791.     CrossRef
  • Clinical Course of COVID-19 in Patients with Inflammatory Bowel Disease in Korea: a KASID Multicenter Study
    Jin Wook Lee, Eun Mi Song, Sung-Ae Jung, Sung Hoon Jung, Kwang Woo Kim, Seong-Joon Koh, Hyun Jung Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Development of a Machine Learning Model to Distinguish between Ulcerative Colitis and Crohn’s Disease Using RNA Sequencing Data
    Soo-Kyung Park, Sangsoo Kim, Gi-Young Lee, Sung-Yoon Kim, Wan Kim, Chil-Woo Lee, Jong-Lyul Park, Chang-Hwan Choi, Sang-Bum Kang, Tae-Oh Kim, Ki-Bae Bang, Jaeyoung Chun, Jae-Myung Cha, Jong-Pil Im, Kwang-Sung Ahn, Seon-Young Kim, Dong-Il Park
    Diagnostics.2021; 11(12): 2365.     CrossRef
  • Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review
    Ji Young Chang, Jae Hee Cheon
    Precision and Future Medicine.2021; 5(4): 151.     CrossRef
  • Therapeutic Drug Monitoring of Biologic Agents in the Era of Precision Medicine
    Soo-Youn Lee
    Annals of Laboratory Medicine.2020; 40(2): 95.     CrossRef
  • Biologic Use Patterns and Predictors for Non-persistence and Switching of Biologics in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    Digestive Diseases and Sciences.2020; 65(5): 1436.     CrossRef
  • Trends in Healthcare Costs for Inflammatory Bowel Disease in South Korea
    Yoon Suk Jung
    Gut and Liver.2020; 14(1): 3.     CrossRef
  • Prevention and management of viral hepatitis in inflammatory bowel disease: a clinical practice guideline by the Korean Association for the Study of Intestinal Diseases
    Soo-Kyung Park, Chang Hwan Choi, Jaeyoung Chun, Heeyoung Lee, Eun Sun Kim, Jae Jun Park, Chan Hyuk Park, Bo-In Lee, Yunho Jung, Dong-Il Park, Do Young Kim, Hana Park, Yoon Tae Jeen
    Intestinal Research.2020; 18(1): 18.     CrossRef
  • Association of Faecal Calprotectin Level and Combined Endoscopic and Radiological Healing in Patients With Crohn’s Disease Receiving Anti-tumour Necrosis Factor Therapy
    Soo Min Noh, Eun Hye Oh, Seong Ho Park, Jung Bok Lee, Jin Yong Kim, Jae Cheol Park, Jeongseok Kim, Nam Seok Ham, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beyong Duk Ye
    Journal of Crohn's and Colitis.2020; 14(9): 1231.     CrossRef
  • Changes in prevalence and perception of complementary and alternative medicine use in Korean inflammatory bowel disease patients: results of an 8-year follow-up survey
    Sun-Ho Lee, Kiju Chang, Ki Seok Seo, Yun Kyung Cho, Eun Mi Song, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Intestinal Research.2020; 18(2): 192.     CrossRef
  • Indigo Naturalis Alleviates Dextran Sulfate Sodium-Induced Colitis in Rats via Altering Gut Microbiota
    Zhongmei Sun, Junxiang Li, Yi Dai, Wenting Wang, Rui Shi, Zhibin Wang, Panghua Ding, Qiongqiong Lu, Hui Jiang, Wenjing Pei, Xingjie Zhao, Yi Guo, Jiali Liu, Xiang Tan, Tangyou Mao
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Similar Clinical Outcomes of Early and Late Anti-TNF Initiation for Ulcerative Colitis: A Nationwide Population-Based Study
    Minkyung Han, Yoon Suk Jung, Jae Hee Cheon, Sohee Park
    Yonsei Medical Journal.2020; 61(5): 382.     CrossRef
  • Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea
    Jae Myung Cha, Sang Hyoung Park, Kyoung Hoon Rhee, Sung Noh Hong, Young-Ho Kim, Seung In Seo, Kyung Ho Kim, Seung Kyu Jeong, Ji Hyun Lee, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O
    Gut.2020; 69(8): 1432.     CrossRef
  • Inflammatory Bowel Disease – Non-biological treatment
    Fernando Magro, Gonçalo Cordeiro, Andreia Martins Dias, Maria Manuela Estevinho
    Pharmacological Research.2020; 160: 105075.     CrossRef
  • Use of small bowel capsule endoscopy in clinical practice: how has it performed?
    Seong Ran Jeon
    The Korean Journal of Internal Medicine.2020; 35(4): 854.     CrossRef
  • Impact of early anti-TNF use on clinical outcomes in Crohn’s disease: a nationwide population-based study
    Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon
    The Korean Journal of Internal Medicine.2020; 35(5): 1104.     CrossRef
  • Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model
    Jung Min Kim, Da Hye Kim, Hyo Jeong Park, Hyun Woo Ma, I Seul Park, Mijeong Son, So Youn Ro, Seokmann Hong, Hyo Kyung Han, Soo Jeong Lim, Seung Won Kim, Jae Hee Cheon
    Journal of Nanobiotechnology.2020;[Epub]     CrossRef
  • Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia
    Rupa Banerjee, Partha Pal, Joyce Wing Yan Mak, Siew C Ng
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1076.     CrossRef
  • Optimising management strategies of inflammatory bowel disease in resource-limited settings in Asia
    Siew C Ng, Joyce Wing Yan Mak, Partha Pal, Rupa Banerjee
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1089.     CrossRef
  • NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine‐induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India
    Rupa Banerjee, Vishnubhotla Venkata Ravikanth, Partha Pal, Govardhan Bale, Urmila Steffie Avanthi, Idan Goren, B. Ganesh Girish, Sasikala Mitnala, D. Nageshwar Reddy
    Alimentary Pharmacology & Therapeutics.2020; 52(11-12): 1683.     CrossRef
  • 28,317 View
  • 931 Download
  • 77 Web of Science
  • 80 Crossref
Close layer
Original Articles
Inflammatory bowel diseases
Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease
Prasenjit Das, Gaurav PS Gahlot, Alka Singh, Vandana Baloda, Ramakant Rawat, Anil K Verma, Gaurav Khanna, Maitrayee Roy, Archana George, Ashok Singh, Aasma Nalwa, Prashant Ramteke, Rajni Yadav, Vineet Ahuja, Vishnubhatla Sreenivas, Siddhartha Datta Gupta, Govind K Makharia
Intest Res 2019;17(3):387-397.   Published online April 22, 2019
DOI: https://doi.org/10.5217/ir.2018.00167
AbstractAbstract PDFPubReaderePub
Background/Aims
The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies.
Methods
We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). From the receiver-operating curve analysis, followed by multivariate and logistic regression analyses, we identified parameters for differentiating control biopsies from those of the patients with CeD. We repeated the quantitative histological analysis in a validation cohort (105 controls and 120 patients with CeD). On the basis of the results, we propose a quantitative histological classification system. The new classification was compared with the existing histological classifications for interobserver and intraobserver agreements by a group of qualified pathologists.
Results
Among the histological parameters, intraepithelial lymphocyte count of ≥25/100 epithelial cells, adjusted villous height fold change of ≤0.7, and crypt depth-to-villous height ratio of ≥0.5 showed good discriminative power between the mucosal biopsies from the patients with CeD and those from the controls, with 90.3% sensitivity, 93.5% specificity, and 96.2% area under the curve. Among the existing histological classifications, our quantitative histological classification showed the highest intraobserver (69.7%–85.03%) and interobserver (24.6%–71.5%) agreements.
Conclusions
Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD. (Intest Res, Published online)

Citations

Citations to this article as recorded by  
  • Celiac Disease Deep Learning Image Classification Using Convolutional Neural Networks
    Joaquim Carreras
    Journal of Imaging.2024; 10(8): 200.     CrossRef
  • CD, or not CD, that is the question: a digital interobserver agreement study in coeliac disease
    James Denholm, Benjamin A Schreiber, Florian Jaeckle, Mike N Wicks, Emyr W Benbow, Tim S Bracey, James Y H Chan, Lorant Farkas, Eve Fryer, Kishore Gopalakrishnan, Caroline A Hughes, Kathryn J Kirkwood, Gerald Langman, Betania Mahler-Araujo, Raymond F T Mc
    BMJ Open Gastroenterology.2024; 11(1): e001252.     CrossRef
  • Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease
    Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia, Sunita Malhotra
    Digestive Diseases and Sciences.2023; 68(2): 529.     CrossRef
  • Usefulness of a double immunofluorescence technique for detection of intestinal tTG-IgA deposits in diabetic and non-diabetic children with celiac disease
    Raghav Lal, Ranjeet Bhardwaj, Ranjana Walker Minz, Kaushal Kishore Prasad, Sadhna Lal, Devi Dayal, Yashwant Kumar
    Pediatrics & Neonatology.2023; 64(4): 388.     CrossRef
  • The global burden of coeliac disease: opportunities and challenges
    Govind K. Makharia, Prashant Singh, Carlo Catassi, David S. Sanders, Daniel Leffler, Raja Affendi Raja Ali, Julio C. Bai
    Nature Reviews Gastroenterology & Hepatology.2022; 19(5): 313.     CrossRef
  • Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study
    Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni
    Nutrients.2022; 14(12): 2487.     CrossRef
  • The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid Tumors
    Sharia Hernandez, Alejandra G. Serrano, Luisa M. Solis Soto
    Advanced Biology.2022;[Epub]     CrossRef
  • Case Report: Morphologic and Functional Characteristics of Intestinal Mucosa in a Child With Short Bowel Syndrome After Treatment With Teduglutide: Evidence in Favor of GLP-2 Analog Safety
    Enrico Costantino Falco, Antonella Lezo, Pierluigi Calvo, Caterina Rigazio, Anna Opramolla, Ludovica Verdun, Giovanna Cenacchi, Marianna Pellegrini, Marco Spada, Gabriella Canavese
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Quantitative histology as a diagnostic tool for celiac disease in children and adolescents
    Mateus M. Vargas, Ricardo Artigiani Neto, Vera L. Sdepanian
    Annals of Diagnostic Pathology.2022; 61: 152031.     CrossRef
  • Best practices of handling, processing, and interpretation of small intestinal biopsies for the diagnosis and management of celiac disease: A joint consensus of Indian association of pathologists and microbiologists and Indian society of gastroenterology
    Prasenjit Das, Kim Vaiphei, AnjaliD Amarapurkar, Puja Sakhuja, Ritambhra Nada, RoopaRachel Paulose, Rachana Chaturvedi, Anuradha Sekaran, Usha Kini, Archana Rastogi, Niraj Kumari, Anna Pulimood, Mala Banerjee, Prateek Kinra, Lavleen Singh, AmarenderSingh
    Indian Journal of Pathology and Microbiology.2021; 64(5): 8.     CrossRef
  • Artificial intelligence in small intestinal diseases: Application and prospects
    Yu Yang, Yu-Xuan Li, Ren-Qi Yao, Xiao-Hui Du, Chao Ren
    World Journal of Gastroenterology.2021; 27(25): 3734.     CrossRef
  • Opportunities and challenges in the management of celiac disease in Asia
    Ashish Agarwal, Ashish Chauhan, Vineet Ahuja, Govind K Makharia
    JGH Open.2020; 4(5): 795.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • Digital histology in celiac disease: A practice changer
    Daniel Vasile Balaban, Mariana Jinga
    Artificial Intelligence in Gastroenterology.2020; 1(1): 1.     CrossRef
  • 7,533 View
  • 177 Download
  • 13 Web of Science
  • 14 Crossref
Close layer
IBD
High risk of tuberculosis during infliximab therapy despite tuberculosis screening in inflammatory bowel disease patients in India
Ashish Agarwal, Saurabh Kedia, Saransh Jain, Vipin Gupta, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Venigalla Pratap Mouli, Rajan Dhingra, Govind Makharia, Vineet Ahuja
Intest Res 2018;16(4):588-598.   Published online October 10, 2018
DOI: https://doi.org/10.5217/ir.2018.00023
AbstractAbstract PDFPubReaderePub
Background/Aims
The data on the risk of tuberculosis (TB) reactivation with infliximab (IFX) in patients with inflammatory bowel disease (IBD) from TB endemic countries, like India, is limited. The risk of TB reactivation on IFX and its predictors in patients with IBD was assessed.
Methods
This retrospective review included consecutive patients with IBD who received IFX, and were on follow-up from January 2005 to November 2017. The data was recorded on age/disease duration, indications for IFX, screening for latent tuberculosis (LTB) before IFX, response to IFX, incidence and duration when TB developed after IFX, and type of TB (pulmonary [PTB]/extra-pulmonary [EPTB]/disseminated).
Results
Of 69 patients (22 ulcerative colitis/47 Crohn’s disease; mean age, 35.6±14.5 years; 50.7% males; median follow-up duration after IFX, 19 months [interquartile range, 5.5–48.7 months]), primary non-response at 8 weeks and secondary loss of response at 26 and 52 weeks were seen in 14.5%, 6% and 15% patients respectively. Prior to IFX, all patients were screened for LTB, 8 (11.6%) developed active TB (disseminated, 62.5%; EPTB, 25%; PTB, 12.5%) after a median of 19 weeks (interquartile range, 14.0–84.5 weeks) of IFX. Of these 8 patients’ none had LTB, even when 7 of 8 were additionally screened with contrast-enhanced chest tomography. Though not statistically significant, more patients with Crohn’s disease than ulcerative colitis (14.9% vs. 4.5%, P=0.21), and those with past history of TB (25% vs. 9.8%, P=0.21), developed TB. Age, gender, disease duration, or extraintestinal manifestations could not predict TB reactivation.
Conclusions
There is an extremely high rate of TB with IFX in Indian patients with IBD. Current screening techniques are ineffective and it is difficult to predict TB after IFX.

Citations

Citations to this article as recorded by  
  • Risk of tuberculosis with anti-TNF therapy in Indian patients with inflammatory bowel disease despite negative screening
    Suprabhat Giri, Sukanya Bhrugumalla, Akash Shukla, Sagar Gangadhar, Srujan Reddy, Sumaswi Angadi, Leela Shinde, Aditya Kale
    Arab Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Biologics, Small Molecules and More in Inflammatory Bowel Disease: The Present and the Future
    Manish Manrai, Atul Abhishek Jha, Saurabh Dawra, Aditya Vikram Pachisia
    Future Pharmacology.2024; 4(1): 279.     CrossRef
  • RATE OF INFECTION (TUBERCULOSIS) IN BRAZILIANS IBD PRIVATE PATIENTS: FOLLOW-UP 15 YEARS
    Didia B CURY, Liana C B CURY, Ana C MICHELETTI, Rogério A OLIVEIRA, José J S GONÇALVES
    Arquivos de Gastroenterologia.2024;[Epub]     CrossRef
  • (Re-)introduction of TNF antagonists and JAK inhibitors in patients with previous tuberculosis: a systematic review
    Thomas Theo Brehm, Maja Reimann, Niklas Köhler, Christoph Lange
    Clinical Microbiology and Infection.2024; 30(8): 989.     CrossRef
  • Regional risk of tuberculosis and viral hepatitis with tumor necrosis factor-alpha inhibitor treatment: A systematic review
    Nina Jahnich, Peter D. Arkwright
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy
    Kyunghwan Oh, Kee Don Choi, Hyeong Ryul Kim, Tae Sun Shim, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
    Clinical Endoscopy.2023; 56(2): 239.     CrossRef
  • CT in the detection of latent tuberculosis: a systematic review
    N. Moore, M. Maher, G. Murphy, M. O'Callaghan Maher, O.J. O'Connor, M.F. McEntee
    Clinical Radiology.2023; 78(8): 568.     CrossRef
  • Miliary Tuberculosis in a Patient With Ulcerative Colitis Treated With Tofacitinib
    Shruti Verma, Arshdeep Singh, Chandan Kakkar, Ashish Tripathi, Vandana Midha, Ajit Sood
    ACG Case Reports Journal.2023; 10(6): e01066.     CrossRef
  • The Risk of Opportunistic Infections in Patients with Inflammatory Bowel Disease
    Maede Ghanaeipour, Nima Behnaminia, Erfan Khadem, Amirhossein Nafari
    The International Journal of Gastroenterology and Hepatology Diseases.2022;[Epub]     CrossRef
  • Association of Tumor Necrosis Factor α Inhibitor Use with Diagnostic Features and Mortality of Tuberculosis in the United States, 2010–2017
    Shereen S Katrak, Rongxia Li, Sue Reynolds, Suzanne M Marks, Jessica R Probst, Terence Chorba, Kevin Winthrop, Kenneth G Castro, Neela D Goswami
    Open Forum Infectious Diseases.2022;[Epub]     CrossRef
  • Stringent screening strategy significantly reduces reactivation rates of tuberculosis in patients with inflammatory bowel disease on anti‐TNF therapy in tuberculosis endemic region
    Peeyush Kumar, Sudheer K. Vuyyuru, Bhaskar Kante, Pabitra Sahu, Sandeep Goyal, Deepak Madhu, Saransh Jain, Mukesh Kumar Ranjan, Sandeep Mundhra, Rithvik Golla, Mukesh Singh, Shubi Virmani, Anvita Gupta, Nidhi Yadav, Mani Kalaivani, Raju Sharma, Prasenjit
    Alimentary Pharmacology & Therapeutics.2022; 55(11): 1431.     CrossRef
  • Increased Risk of Infection With High Infliximab Trough Level
    Suprabhat Giri, Harish Darak
    Journal of Clinical Gastroenterology.2022; 56(4): 374.     CrossRef
  • Editorial: choosing the optimal screening method for latent TB in patients with IBD commencing anti‐TNF‐therapy—authors' reply
    Peeyush Kumar, Sudheer Kumar Vuyyuru, Saurabh Kedia, Vineet Ahuja
    Alimentary Pharmacology & Therapeutics.2022; 55(10): 1348.     CrossRef
  • Positioning of tofacitinib in treatment of ulcerative colitis: a global perspective
    Shubhra Mishra, Anuraag Jena, Rinkalben Kakadiya, Vishal Sharma, Vineet Ahuja
    Expert Review of Gastroenterology & Hepatology.2022; 16(8): 737.     CrossRef
  • Tumor necrosis factor-alpha antibody labeled-polyethylene glycol-coated nanoparticles: A mesenchymal stem cells-based drug delivery system in the rat model of cisplatin-induced nephrotoxicity
    Faten A. M. Abo-Aziza, Saleh M. Albarrak, Abdel-Kader A. Zaki, Shaymaa E. El-Shafey
    Veterinary World.2022; : 2475.     CrossRef
  • Efficacy and safety of biosimilar versus originator infliximab in patients with inflammatory bowel disease: A real-world cohort analysis
    Peeyush Kumar, Sudheer K. Vuyyuru, Bhaskar Kante, Saurabh Kedia, Pabitra Sahu, Mukesh Kumar Ranjan, Sandeep Mundhra, Rithvik Golla, Mukesh Kumar, Shubi Virmani, Anvita Gupta, Nidhi Yadav, Govind Makharia, Vineet Ahuja
    Indian Journal of Gastroenterology.2022; 41(5): 446.     CrossRef
  • Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia
    Shu-Chen Wei, Jose Sollano, Yee Tak Hui, Wei Yu, Paul V. Santos Estrella, Lyndon John Q. Llamado, Nana Koram
    Expert Review of Gastroenterology & Hepatology.2021; 15(3): 275.     CrossRef
  • Various Forms of Tuberculosis in Patients with Inflammatory Bowel Diseases Treated with Biological Agents
    Adam Krusiński, Anna Grzywa-Celińska, Katarzyna Szewczyk, Luiza Grzycka-Kowalczyk, Justyna Emeryk-Maksymiuk, Janusz Milanowski, Andrew S. Day
    International Journal of Inflammation.2021; 2021: 1.     CrossRef
  • Long‐term outcomes of anti‐tumor necrosis factor therapy and surgery in nonperianal fistulizing Crohn's disease
    Sudheer K Vuyyuru, Devendra Desai, Saurabh Kedia, Pavan Dhoble, Pabitra Sahu, Bhaskar Kante, Samagra Agarwal, Sawan Bopanna, Rajan Dhingra, Pratap Mouli Venigalla, Raju Sharma, Siddhartha Datta Gupta, Govind Makharia, Peush Sahni, Vineet Ahuja
    JGH Open.2021; 5(4): 420.     CrossRef
  • Efficacy and tolerability of exclusive enteral nutrition in adult patients with complicated Crohn’s disease
    Sanchit Sharma, Arti Gupta, Saurabh Kedia, Samagra Agarwal, Namrata Singh, Sandeep Goyal, Saransh Jain, Vipin Gupta, Pabitra Sahu, Sudheer Kumar Vuyyuru, Bhaskar Kante, Raju Sharma, Rajesh Panwar, Peush Sahni, Govind Makharia, Vineet Ahuja
    Intestinal Research.2021; 19(3): 291.     CrossRef
  • Monitoring frequency of interferon gamma release assay for tuberculosis surveillance following infliximab therapy in patients with Crohn's disease
    Qin Yu Yang, Yi Juan Liu, Ye Xu, Lin Zhang, Cheng Dang Wang
    Journal of Digestive Diseases.2021; 22(8): 473.     CrossRef
  • COVID-19-associated opportunistic infections: a snapshot on the current reports
    Amir Abdoli, Shahab Falahi, Azra Kenarkoohi
    Clinical and Experimental Medicine.2021; 22(3): 327.     CrossRef
  • Efficacy and Safety of Fecal Transplantation Versus Targeted Therapies in Ulcerative Colitis: Network Meta-Analysis
    Sudheer K Vuyyuru, Saurabh Kedia, Mani Kalaivani, Pabitra Sahu, Bhaskar Kante, Peeyush Kumar, Mukesh K Ranjan, Govind Makharia, Ashwin Ananthakrishnan, Vineet Ahuja
    Future Microbiology.2021; 16(15): 1215.     CrossRef
  • A case report of probable ocular tuberculosis following biologics
    Sudha K. Ganesh, Divya Thatikonda
    Indian Journal of Ophthalmology - Case Reports.2021; 1(4): 683.     CrossRef
  • Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
    Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Tacrolimus as rescue therapy for steroid-dependent/steroid-refractory ulcerative colitis: Experience from tertiary referral center in India
    Sukrit Sud, Sanjeev Sachdeva, Amarender Singh Puri
    Indian Journal of Gastroenterology.2021; 40(6): 598.     CrossRef
  • Vedolizumab in Inflammatory Bowel Disease: West versus East
    Prasanta Debnath, Pravin M. Rathi
    Inflammatory Intestinal Diseases.2021; 6(1): 1.     CrossRef
  • Antitubercular Therapy Given to Differentiate Crohn’s Disease From Intestinal Tuberculosis Predisposes to Stricture Formation
    Akshita Gupta, Venigalla Pratap Mouli, Srikant Mohta, Bhaskar Kante, Mani Kalaivani, Deepak Madhu, Pabitra Sahu, Sudheer Kumar, Raju Sharma, Peush Sahni, Prasenjit Das, Siddharth Datta Gupta, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Journal of Crohn's and Colitis.2020; 14(11): 1611.     CrossRef
  • Relapse rate following withdrawal of anti-TNF therapy in patients with inflammatory bowel disease: A real-life cohort from northern India
    Pabitra Sahu, Sudheer K. Vuyyuru, Bhaskar Kante, Ashish Agarwal, Raju Sharma, Prasenjit Das, Rajesh Panwar, Saransh Jain, Sawan Bopanna, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Indian Journal of Gastroenterology.2020; 39(4): 388.     CrossRef
  • Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model
    Jung Min Kim, Da Hye Kim, Hyo Jeong Park, Hyun Woo Ma, I Seul Park, Mijeong Son, So Youn Ro, Seokmann Hong, Hyo Kyung Han, Soo Jeong Lim, Seung Won Kim, Jae Hee Cheon
    Journal of Nanobiotechnology.2020;[Epub]     CrossRef
  • Long-term outcomes in perianal fistulizing Crohn’s disease in a resource-limited setting: A cohort analysis
    Sudheer K. Vuyyuru, Pabitra Sahu, Saurabh Kedia, Bhaskar Kante, Peeyush Kumar, Mukesh Kumar Ranjan, Raju Sharma, Govind Makharia, S. D. Gupta, Peush Sahni, Vineet Ahuja
    Indian Journal of Gastroenterology.2020; 39(5): 435.     CrossRef
  • Higher risk of tuberculosis in combination therapy for inflammatory bowel disease
    Seong Ji Choi, Min Sun Kim, Eun Sun Kim, Juneyoung Lee, Jae Min Lee, Hyuk Soon Choi, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim
    Medicine.2020; 99(44): e22897.     CrossRef
  • Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia
    Rupa Banerjee, Partha Pal, Joyce Wing Yan Mak, Siew C Ng
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1076.     CrossRef
  • Effectiveness and safety of adalimumab biosimilar in inflammatory bowel disease: A multicenter study
    Nagesh Kamat, Saurabh Kedia, Uday C. Ghoshal, Abhimanyu Nehra, Govind Makharia, Ajit Sood, Vandana Midha, Varun Gupta, Gourdas Choudhuri, Vineet Ahuja
    Indian Journal of Gastroenterology.2019; 38(1): 44.     CrossRef
  • Multidrug-resistant Disseminated Tuberculosis Related to Infliximab in a Patient with Ulcerative Colitis and Negative Evaluation for Latent Tuberculosis
    Yu Kyung Jun, Jaeyoung Chun, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
    The Korean Journal of Gastroenterology.2019; 74(3): 168.     CrossRef
  • 8,062 View
  • 196 Download
  • 31 Web of Science
  • 35 Crossref
Close layer
IBD
Selective M1 macrophage polarization in granuloma-positive and granuloma-negative Crohn's disease, in comparison to intestinal tuberculosis
Prasenjit Das, Ritika Rampal, Sonakshi Udinia, Tarun Kumar, Sucharita Pilli, Nahid Wari, Imtiaz Khan Ahmed, Saurabh Kedia, Siddhartha Datta Gupta, Dhiraj Kumar, Vineet Ahuja
Intest Res 2018;16(3):426-435.   Published online July 27, 2018
DOI: https://doi.org/10.5217/ir.2018.16.3.426
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Classical M1 macrophage activation exhibits an inflammatory phenotype while alternative M2 macrophage activation exhibits an anti-inflammatory phenotype. We aimed to determine whether there are discriminant patterns of macrophage polarization in Crohn's disease (CD) and intestinal tuberculosis (iTB).

Methods

Colonic mucosal biopsies from 29 patients with iTB, 50 with CD, and 19 controls were examined. Dual colored immunohistochemistry was performed for iNOS/CD68 (an M1φ marker) and CD163/CD68 (an M2φ marker), and the ratio of M1φ to M2φ was assessed. To establish the innate nature of macrophage polarization, we analyzed the extent of mitochondrial depolarization, a key marker of inflammatory responses, in monocyte-derived macrophages obtained from CD and iTB patients, following interferon-γ treatment.

Results

M1φ polarization was more prominent in CD biopsies (P=0.002) than in iTB (P=0.2) and control biopsies. In granuloma-positive biopsies, including those in CD, M1φ predominance was significant (P=0.001). In iTB, the densities of M1φ did not differ between granuloma-positive and granuloma-negative biopsies (P=0.1). Interestingly, higher M1φ polarization in CD biopsies correlated with high inflammatory response exhibited by peripheral blood-derived monocytes from these patients.

Conclusions

Proinflammatory M1φ polarization was more common in colonic mucosa of CD patients, especially in the presence of mucosal granulomas. Further characterization of the innate immune system could help in clarifying the pathology of iTB and CD.

Citations

Citations to this article as recorded by  
  • Macrophage polarization: an important role in inflammatory diseases
    Min Luo, Fukun Zhao, Huan Cheng, Mu Su, Yuanmin Wang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • The gut barrier as a gatekeeper in colorectal cancer treatment
    Roy Hajjar, Carole Richard, Manuela M. Santos
    Oncotarget.2024; 15(1): 562.     CrossRef
  • New diagnostic strategies to distinguish Crohn's disease and gastrointestinal tuberculosis
    Himanshu Narang, Saurabh Kedia, Vineet Ahuja
    Current Opinion in Infectious Diseases.2024; 37(5): 392.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Clinical Usefulness of Immune Profiling for Differential Diagnosis between Crohn’s Disease, Intestinal Tuberculosis, and Behcet’s Disease
    Ji Won Yoo, Su In Jo, Dong Woo Shin, Ji Won Park, Sung-Eun Kim, Hyun Lim, Ho Suk Kang, Sung-Hoon Moon, Min Kyu Kim, Sang-Yeob Kim, Sung Wook Hwang, Jae Seung Soh
    Diagnostics.2023; 13(18): 2904.     CrossRef
  • Production of granulomas in Mycoplasma bovis infection associated with meningitis-meningoencephalitis, endocarditis, and pneumonia in cattle
    Mathurot Suwanruengsri, Ryoko Uemura, Takuya Kanda, Naoyuki Fuke, Phawut Nueangphuet, Apisit Pornthummawat, Masahiro Yasuda, Takuya Hirai, Ryoji Yamaguchi
    Journal of Veterinary Diagnostic Investigation.2022; 34(1): 68.     CrossRef
  • Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis
    Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Arunmani Mani, Ramesha Papanna, Lovepreet K. Mann, Eder Ledezma-Campos, Genesis Aguillon-Duran, David H. Canaday, Sunil A. David, Blanca I. Restrepo,
    Communications Biology.2022;[Epub]     CrossRef
  • Lacticaseibacillus casei Strain Shirota Modulates Macrophage-Intestinal Epithelial Cell Co-Culture Barrier Integrity, Bacterial Sensing and Inflammatory Cytokines
    Andrew Foey, Neama Habil, Alex Strachan, Jane Beal
    Microorganisms.2022; 10(10): 2087.     CrossRef
  • Biomaterial-based osteoimmunomodulatory strategies via the TLR4-NF-κB signaling pathway: A review
    Haiyuan Xing, Ruiyan Li, Yun'an Qing, Boda Ying, Yanguo Qin
    Applied Materials Today.2021; 22: 100969.     CrossRef
  • Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model
    Ming-Ko Chiang, Pei-Yi Hsiao, Yen-Yi Liu, Hui-Ling Tang, Chien-Shun Chiou, Min-Chi Lu, Yi-Chyi Lai
    Gut Microbes.2021;[Epub]     CrossRef
  • A combination of circulating microRNA-375-3p and chemokines CCL11, CXCL12, and G-CSF differentiate Crohn’s disease and intestinal tuberculosis
    Susree Roy, Suchandrima Ghosh, Mallica Banerjee, Sayantan Laha, Dipanjan Bhattacharjee, Rajib Sarkar, Sujay Ray, Arko Banerjee, Ranajoy Ghosh, Aniket Halder, Alakendu Ghosh, Raghunath Chatterjee, Simanti Datta, Gopal Krishna Dhali, Soma Banerjee
    Scientific Reports.2021;[Epub]     CrossRef
  • Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization
    Xiao Liu, Yan Su, Xueyan Sun, Haixia Fu, Qiusha Huang, Qi Chen, Xiaodong Mo, Meng Lv, Yuan Kong, Lanping Xu, Xiaojun Huang, Xiaohui Zhang
    Science China Life Sciences.2020; 63(11): 1744.     CrossRef
  • Heterogeneous macrophages: Supersensors of exogenous inducing factors
    Caiyun Qian, Zehui Yun, Yudi Yao, Minghua Cao, Qiang Liu, Song Hu, Shuhua Zhang, Daya Luo
    Scandinavian Journal of Immunology.2019;[Epub]     CrossRef
  • Understanding Pathogenesis and Care Challenges of Immune Reconstitution Inflammatory Syndrome in Fungal Infections
    Sarah Dellière, Romain Guery, Sophie Candon, Blandine Rammaert, Claire Aguilar, Fanny Lanternier, Lucienne Chatenoud, Olivier Lortholary
    Journal of Fungi.2018; 4(4): 139.     CrossRef
  • 11,351 View
  • 130 Download
  • 14 Web of Science
  • 14 Crossref
Close layer
Review
IBD
Management of inflammatory bowel disease in older persons: evolving paradigms
Saurabh Kedia, Jimmy K. Limdi, Vineet Ahuja
Intest Res 2018;16(2):194-208.   Published online April 30, 2018
DOI: https://doi.org/10.5217/ir.2018.16.2.194
AbstractAbstract PDFPubReaderePub

The incidence and prevalence of inflammatory bowel disease (IBD) is increasing, and considering the aging population, this number is set to increase further in the future. The clinical features and natural history of elderly-onset IBD have many similarities with those of IBD in younger patients, but with significant differences including a broader differential diagnosis. The relative lack of data specific to elderly patients with IBD, often stemming from their typical exclusion from clinical trials, has made clinical decision-making somewhat challenging. Treatment decisions in elderly patients with IBD must take into account age-specific concerns such as comorbidities, locomotor and cognitive function, and polypharmacy, to set realistic treatment targets in order to enable personalized treatment and minimize harm. Notwithstanding paucity of clinical data, recent studies have provided valuable insights, which, taken together with information gleaned from previous studies, can broaden our understanding of IBD. These insights may contribute to the development of paradigms for the holistic and, when possible, evidence-based management of this potentially vulnerable population and are the focus of this review.

Citations

Citations to this article as recorded by  
  • Fatigue, sarcopenia, and frailty in older adults with inflammatory bowel disease
    Federica BELLONE, Alberto SARDELLA, Marco MUSCIANISI, Giorgio BASILE
    Minerva Gastroenterology.2024;[Epub]     CrossRef
  • Histology of IBD and related colitides in the elderly
    Giuseppe LEONCINI, Luca REGGIANI-BONETTI, Gloria SIMONCELLI, Vincenzo VILLANACCI
    Minerva Gastroenterology.2024;[Epub]     CrossRef
  • Age over sex: evaluating gut microbiota differences in healthy Chinese populations
    Jiacheng Wu, Hexiao Shen, Yongling Lv, Jing He, Xiaotian Xie, Zhiyue Xu, Pengcheng Yang, Wei Qian, Tao Bai, Xiaohua Hou
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Clinical outcomes amongst elderly patients with inflammatory bowel disease
    Vithoosharan Sivanathan, Chamara Basnayake, William Connell, Emily Wright, John Nik Ding, Ola Niewadomski, Annalise Stanley, Amy Wilson‐O'Brien, Stephanie Fry, Tamie Samyue, Mark Lust, Emma Flanagan, Alexander J. V. Thompson, Michael A. Kamm
    Internal Medicine Journal.2023; 53(10): 1866.     CrossRef
  • Non-neoplastic disorders in an aging gut: concise review
    Saurabh Dawra, Pradeep Behl, Sharad Srivastava, Manish Manrai, Alok Chandra, Anupam Kumar, Ankit Kumar, Manveer Singh Tevatia
    The Egyptian Journal of Internal Medicine.2023;[Epub]     CrossRef
  • Enfermedad Inflamatoria Intestinal en el adulto mayor: Características clínicas y manejo en un hospital de referencia
    Juan Eloy Paredes Méndez, Sonia Irene Pérez Junes, Henry Tomás Vargas Marcacuzco, Edith Melissa Villafuerte Méndez
    Revista de Gastroenterología del Perú.2023; 43(1): 13.     CrossRef
  • Clinical spectrum of elderly-onset inflammatory bowel disease in India
    Yogesh Kumar Gupta, Arshdeep Singh, Vikram Narang, Vandana Midha, Ramit Mahajan, Varun Mehta, Dharmatma Singh, Namita Bansal, Madeline Vithya Barnaba Durairaj, Amit Kumar Dutta, Ajit Sood
    Intestinal Research.2023; 21(2): 216.     CrossRef
  • A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases
    Michał Sienkiewicz, Kamila Sroka, Agata Binienda, Diana Jurk, Jakub Fichna
    Ageing Research Reviews.2023; 91: 102083.     CrossRef
  • Representation and reporting of diverse groups in randomised controlled trials of pharmacological agents in inflammatory bowel disease: a systematic review
    Mythili Menon Pathiyil, Anuraag Jena, Arvind Kumar Venkataramana Raju, Tina Aswani Omprakash, Vishal Sharma, Shaji Sebastian
    The Lancet Gastroenterology & Hepatology.2023; 8(12): 1143.     CrossRef
  • Relation of geriatric nutritional risk index with clinical risks in elderly‐onset ulcerative colitis
    Masaaki Higashiyama, Shunsuke Komoto, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Soichiro Miura, Ryota Hokari
    Journal of Gastroenterology and Hepatology.2021; 36(1): 163.     CrossRef
  • Atopic dermatitis does not increase the risk of inflammatory bowel disease: A nationwide cohort study
    Yu‐Ching Weng, Chao‐Kuei Juan, Hsiu J. Ho, Yi‐Ling Chang, Chun‐Ying Wu, Yi‐Ju Chen
    The Journal of Dermatology.2021; 48(2): 168.     CrossRef
  • Common Diarrheal Illnesses in the Elderly
    Enad Dawod, Carl V. Crawford
    Clinics in Geriatric Medicine.2021; 37(1): 103.     CrossRef
  • Inflammatory Bowel Disease: Managing Complex Patients
    Paula Miksa, Shane Ryan Apperley
    Physician Assistant Clinics.2021; 6(4): 655.     CrossRef
  • The dietary practices and beliefs of people living with older-onset inflammatory bowel disease
    Benjamin Crooks, Ravi Misra, Naila Arebi, Klaartje Kok, Matthew J. Brookes, John McLaughlin, Jimmy K. Limdi
    European Journal of Gastroenterology & Hepatology.2021; 33(1S): e442.     CrossRef
  • Inflammatory bowel disease (IBD) position statement of the Italian Society of Colorectal Surgery (SICCR): general principles of IBD management
    G. Pellino, D. S. Keller, G. M. Sampietro, V. Annese, M. Carvello, V. Celentano, C. Coco, F. Colombo, N. Cracco, F. Di Candido, M. Franceschi, S. Laureti, G. Mattioli, L. Pio, G. Sciaudone, G. Sica, V. Villanacci, R. Zinicola, S. Leone, S. Danese, A. Spin
    Techniques in Coloproctology.2020; 24(2): 105.     CrossRef
  • Case 8-2020: An 89-Year-Old Man with Recurrent Abdominal Pain and Bloody Stools
    Richard C. Cabot, Eric S. Rosenberg, Virginia M. Pierce, David M. Dudzinski, Meridale V. Baggett, Dennis C. Sgroi, Jo-Anne O. Shepard, Kathy M. Tran, Emily K. McDonald, Tara Corpuz, Hacho B. Bohossian, Emily W. Lopes, Lauren A. Roller, Ashwin N. Ananthakr
    New England Journal of Medicine.2020; 382(11): 1042.     CrossRef
  • Elderly-onset vs adult-onset ulcerative colitis: a different natural history?
    Irene Zammarchi, Francesco Lanzarotto, Rosanna Cannatelli, Francesca Munari, Federica Benini, Alessandro Pozzi, Alberto Lanzini, Chiara Ricci
    BMC Gastroenterology.2020;[Epub]     CrossRef
  • Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
    Yi-Ju Chen, Chao-Kuei Juan, Yun-Ting Chang, Chun-Ying Wu, Hsiu J. Ho, Hsiao-Ching Tseng
    Scientific Reports.2020;[Epub]     CrossRef
  • Dietary Support in Elderly Patients with Inflammatory Bowel Disease
    Piotr Eder, Alina Niezgódka, Iwona Krela-Kaźmierczak, Kamila Stawczyk-Eder, Estera Banasik, Agnieszka Dobrowolska
    Nutrients.2019; 11(6): 1421.     CrossRef
  • Exploring the therapeutic potential of sodium benzoate in acetic acid-induced ulcerative colitis in rats
    Deepali Walia, Gurpreet Kaur, Amteshwar Singh Jaggi, Anjana Bali
    Journal of Basic and Clinical Physiology and Pharmacology.2019;[Epub]     CrossRef
  • 8,110 View
  • 181 Download
  • 21 Web of Science
  • 20 Crossref
Close layer
Original Articles
IBD
Are Truelove and Witts criteria for diagnosing acute severe colitis relevant for the Indian population? A prospective study
Saransh Jain, Saurabh Kedia, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Peush Sahni, Sujoy Pal, Nihar Ranjan Dash, Govind Makharia, Simon P. L. Travis, Vineet Ahuja
Intest Res 2018;16(1):69-74.   Published online January 18, 2018
DOI: https://doi.org/10.5217/ir.2018.16.1.69
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Truelove and Witts criteria have been used to define acute severe colitis since the 1950s. However, hemoglobin (an additional criterion of the definition) levels in the general population in developing countries are lower than in the population of developed countries. We aimed to determine the relevance of Truelove and Witts criteria in the Indian population.

Methods

Consecutive patients with acute severe colitis satisfying the Truelove and Witts criteria, hospitalized at a single center between April 2015 and December 2016 were included. All patients received intravenous corticosteroids and 16 required colectomy. The hemoglobin levels at admission were subsequently excluded from the classification criteria, and the effect this had on the criteria for diagnosis was determined.

Results

Out of 61 patients of acute severe colitis diagnosed according to the original Truelove and Witts criteria, 12 patients (20%) had 1 additional criterion, 33 (54%) had 2 additional criteria and 16 (26%) had 3 or more additional criteria in addition to 6 or more blood stained stools on admission. On excluding hemoglobin as an additional criterion from the Truelove and Witts definition, all patients still met the criteria for acute severe colitis.

Conclusions

Truelove and Witts criteria can be used to define acute severe colitis in India, despite lower mean hemoglobin in the native population.

Citations

Citations to this article as recorded by  
  • Early management of acute severe UC in the biologics era: development and international validation of a prognostic clinical index to predict steroid response
    Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen GC McGregor, Tim Ambrose, Bruce D George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P
    Gut.2023; 72(3): 433.     CrossRef
  • Inflammatory bowel disease: An Indian perspective
    Mayank Jain, Jayanthi Venkataraman
    Indian Journal of Medical Research.2021; 153(4): 421.     CrossRef
  • High Serum Osmolality May Predict the Disease Severity in Patients with Acute Ulcerative Colitis
    Abdussamed VURAL, Aslı VURAL, Selahattin VURAL, Selim TURFAN, Ahmet Cumhur DÜLGER
    Online Türk Sağlık Bilimleri Dergisi.2020; 5(2): 324.     CrossRef

  • Relationship Between Vitamin D Deficiency and Disease Activity in Patients with Inflammatory Bowel Disease in Ahvaz, Iran


    Esmat Rasouli, Narges Sadeghi, Abazar Parsi, Seyed Jalal Hashemi, Morteza Nayebi, Aliakbar Shayesteh
    Clinical and Experimental Gastroenterology.2020; Volume 13: 419.     CrossRef
  • A current overview of corticosteroid use in active ulcerative colitis
    Marco Salice, Fernando Rizzello, Carlo Calabrese, Lucia Calandrini, Paolo Gionchetti
    Expert Review of Gastroenterology & Hepatology.2019; 13(6): 557.     CrossRef
  • Optimal management of acute severe ulcerative colitis
    Saransh Jain, Vineet Ahuja, Jimmy K Limdi
    Postgraduate Medical Journal.2019; 95(1119): 32.     CrossRef
  • A challenge in diagnosis and management of ulcerative colitis in elderly patient with atypical presentation: A reported case
    Panutchaya Kongon, Vorapatu Tangsirapat, Vittawat Ohmpornuwat, Kannakrit Sumtong, Vichack Chakrapan Na Ayudhya, Kobkool Chakrapan Na Ayudhya, Paiboon Sookpotarom, Paisarn Vejchapipat
    International Journal of Surgery Case Reports.2019; 61: 234.     CrossRef
  • 7,913 View
  • 75 Download
  • 6 Web of Science
  • 7 Crossref
Close layer
Predictive factors for malignancy in undiagnosed isolated small bowel strictures
Ujjwal Sonika, Sujeet Saha, Saurabh Kedia, Nihar Ranjan Dash, Sujoy Pal, Prasenjit Das, Vineet Ahuja, Peush Sahni
Intest Res 2017;15(4):518-523.   Published online October 23, 2017
DOI: https://doi.org/10.5217/ir.2017.15.4.518
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Patients with small bowel strictures have varied etiologies, including malignancy. Little data are available on the demographic profiles and etiologies of small bowel strictures in patients who undergo surgery because of intestinal obstruction but do not have a definitive pre-operative diagnosis.

Methods

Retrospective data were analyzed for all patients operated between January 2000 and October 2014 for small bowel strictures without mass lesions and a definite diagnosis after imaging and endoscopic examinations. Demographic parameters, imaging, endoscopic, and histological data were extracted from the medical records. Univariate and multivariate analyses were conducted to identify factors that could differentiate between intestinal tuberculosis (ITB) and Crohn's disease (CD) and between malignant and benign strictures.

Results

Of the 7,425 reviewed medical records, 89 met the inclusion criteria. The most common site of strictures was the proximal small intestine (41.5%). The most common histological diagnoses in patients with small bowel strictures were ITB (26.9%), CD (23.5%), non-specific strictures (20.2%), malignancy (15.5%), ischemia (10.1%), and other complications (3.4%). Patients with malignant strictures were older than patients with benign etiologies (47.6±15.9 years vs. 37.4±16.4 years, P=0.03) and age >50 years had a specificity for malignant etiology of 80%. Only 7.1% of the patients with malignant strictures had more than 1 stricture and 64% had proximally located strictures. Diarrhea was the only factor that predicted the diagnosis of CD 6.5 (95% confidence interval, 1.10–38.25; P=0.038) compared with the diagnosis of ITB.

Conclusions

Malignancy was the cause of small bowel strictures in approximately 16% patients, especially among older patients with a single stricture in the proximal location. Empirical therapy should be avoided and the threshold for surgical resection is low in these patients.

Citations

Citations to this article as recorded by  
  • Cryptogenic multifocal ulcerous stenosing enteritis: A ray of light on the umbra of the dark continent
    Mithu Bhowmick, Vishal Sharma
    Indian Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Ileal endometriosis: a rare cause of multifocal small bowel strictures
    Timothy Peacock, William Harrison, Alexandra Limmer, Suzanne Di Sano, King‐Sang Wong
    ANZ Journal of Surgery.2022; 92(7-8): 1914.     CrossRef
  • Infectious diseases affecting the small bowel – what not to miss
    Martin Keuchel, Marc Bota, Peter Baltes
    Current Opinion in Gastroenterology.2021; 37(3): 255.     CrossRef
  • Small bowel ulcers
    Martin Keuchel, Niehls Kurniawan, Peter Baltes
    Current Opinion in Gastroenterology.2019; 35(3): 213.     CrossRef
  • Rebleeding rate and risk factors in nonsteroidal anti‐inflammatory drug‐induced enteropathy
    Junseok Park, Seong Ran Jeon, Jin‐Oh Kim, Hyun Gun Kim, Tae Hee Lee, Jun‐Hyung Cho, Bong Min Ko, Joon Seong Lee, Moon Sung Lee
    Journal of Digestive Diseases.2018; 19(5): 279.     CrossRef
  • 5,050 View
  • 59 Download
  • 5 Web of Science
  • 5 Crossref
Close layer
Familial aggregation of inflammatory bowel disease in patients with ulcerative colitis
Akshita Gupta, Sawan Bopanna, Saurabh Kedia, Dawesh Prakash Yadav, Sandeep Goyal, Saransh Jain, Govind Makharia, Vineet Ahuja
Intest Res 2017;15(3):388-394.   Published online June 12, 2017
DOI: https://doi.org/10.5217/ir.2017.15.3.388
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Familial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC.

Methods

Records of patients with UC followed at the Inflammatory Bowel Disease Clinic at the All India Institute of Medical Sciences, New Delhi from August 2004 to January 2016 were reviewed. Details regarding the prevalence of family history and characteristics of these patients were recorded. Affected family members were contacted and disease characteristics were noted for assessment of familial aggregation.

Results

Of the 2,058 UC patients included in the analysis, a positive family history of IBD was confirmed in 31 patients (1.5%), 24 (77.4%) of whom had only first-degree relatives affected. All the affected relatives had UC and none had Crohn's disease. Among first-degree relatives, siblings were found to have the highest prevalence of IBD (53.3%), followed by parents (26.7%).

Conclusions

The probability of occurrence of IBD in family members of affected North Indian UC patients is lower than that reported in Western populations.

Citations

Citations to this article as recorded by  
  • Childhood antibiotics as a risk factor for Crohn's disease: The ENIGMA International Cohort Study
    Joyce W Y Mak, Sun Yang, Annalise Stanley, Xiaoqing Lin, Mark Morrison, Jessica Y L Ching, Junkun Niu, Amy L Wilson‐O'Brien, Rui Feng, Whitney Tang, Amy L Hamilton, Leo Or, Gina L Trakman, Winnie Y Y Lin, Joseph J Y Sung, Ming Hu Chen, Yinglei Mao, Michae
    JGH Open.2022; 6(6): 369.     CrossRef
  • Does the road to primary prevention of inflammatory bowel disease start from childhood?
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2022; 6(6): 365.     CrossRef
  • Cross Talk between Gut Microbiota and Intestinal Mucosal Immunity in the Development of Ulcerative Colitis
    Junfeng Zou, Chen Liu, Shu Jiang, Dawei Qian, Jinao Duan, Anthony R. Richardson
    Infection and Immunity.2021;[Epub]     CrossRef
  • Factors Affecting Ulcerative Colitis Flare-Ups: Associations With Smoking Habits and Other Patient Characteristics
    Nadim H Malibary, Mohammed A Ezzat, Ahmed M Mogharbel, Khalid A Kouzaba, Abdulaziz A Alkadi, Usama H Malki, Sultan M Gharib, Faisal M Altowairqi, Omar I Saadah, Mahmoud H Mosli
    Cureus.2021;[Epub]     CrossRef
  • Inflammatory bowel disease: An Indian perspective
    Mayank Jain, Jayanthi Venkataraman
    Indian Journal of Medical Research.2021; 153(4): 421.     CrossRef
  • Familial aggregation of inflammatory bowel disease in India: prevalence, risks and impact on disease behavior
    Rupa Banerjee, Partha Pal, Susan Hutfless, B Girish Ganesh, D Nageshwar Reddy
    Intestinal Research.2019; 17(4): 486.     CrossRef
  • Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis
    Xue Bing, Liang Linlang, Chen Keyan
    Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1.     CrossRef
  • Is the emergence of inflammatory bowel disease a prime example of “the third epidemiological transition”?
    Saurabh Kedia, Vineet Ahuja
    Indian Journal of Gastroenterology.2018; 37(3): 183.     CrossRef
  • 6,025 View
  • 37 Download
  • 10 Web of Science
  • 8 Crossref
Close layer
Evaluation of Xpert MTB/RIF assay performance in the diagnosis of abdominal tuberculosis
Suraj Kumar, Sawan Bopanna, Saurabh Kedia, Pratap Mouli, Rajan Dhingra, Rajesh Padhan, Mikashmi Kohli, Jigyasa Chaubey, Rohini Sharma, Prasenjit Das, S Dattagupta, Govind Makharia, SK Sharma, Vineet Ahuja
Intest Res 2017;15(2):187-194.   Published online April 27, 2017
DOI: https://doi.org/10.5217/ir.2017.15.2.187
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

The use of genetic probes for the diagnosis of pulmonary tuberculosis (TB) has been well described. However, the role of these assays in the diagnosis of intestinal tuberculosis is unclear. We therefore assessed the diagnostic utility of the Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) assay, and estimated the prevalence of multidrug-resistant (MDR) TB in the Indian population.

Methods

Of 99 patients recruited, 37 had intestinal TB; two control groups comprised 43 with Crohn's disease (CD) and 19 with irritable bowel syndrome. Colonoscopy was performed before starting any therapy; mucosal biopsies were subjected to histopathology, acid-fast bacilli staining, Lowenstein-Jensen culture, and nucleic acid amplification testing using the Xpert MTB/RIF assay. Patients were followed up for 6 months to confirm the diagnosis and response to therapy. A composite reference standard was used for diagnosis of TB and assessment of the diagnostic utility of the Xpert MTB/RIF assay.

Results

Of 37 intestinal TB patients, the Xpert MTB/RIF assay was positive in three of 37 (8.1%), but none had MDR-TB. The sensitivity, specificity, positive predictive value, and negative predictive value of the Xpert MTB/RIF assay was 8.1%, 100%, 100%, and, 64.2%, respectively.

Conclusions

The Xpert MTB/RIF assay has low sensitivity but high specificity for intestinal TB, and may be helpful in endemic tuberculosis areas, when clinicians are faced with difficulty differentiating TB and CD. Based on the Xpert MTB/RIF assay, the prevalence of intestinal MDR-TB is low in the Indian population.

Citations

Citations to this article as recorded by  
  • Perfusion Computed Tomography May Help in Discriminating Gastrointestinal Tuberculosis and Crohn’s Disease
    Raghav Seth, Pankaj Gupta, Uma Debi, Kaushal Kishore Prasad, Harjeet Singh, Vishal Sharma
    Diagnostics.2023; 13(7): 1255.     CrossRef
  • Clinical characteristics and diagnosis of intestinal tuberculosis in clinical practice at Thailand’s largest national tertiary referral center: An 11-year retrospective review
    Asawin Sudcharoen, Gahwin Ruchikajorndech, Sitthipong Srisajjakul, Ananya Pongpaibul, Popchai Ngamskulrungroj, Orawan Tulyaprawat, Julajak Limsrivilai, Mao-Shui Wang
    PLOS ONE.2023; 18(4): e0282392.     CrossRef
  • Analytical performances of the Xpert MTB/RIF assay using stool specimens to improve the diagnosis of pulmonary tuberculosis in Burkina Faso, a tuberculosis endemic country
    Odilon D. Kaboré, Anselme Millogo, Bintou Sanogo, Emile Birba, Armel Poda, Boubacar Nacro, Olivier Marcy, Sylvain Godreuil, Abdoul-Salam Ouédraogo, Mao-Shui Wang
    PLOS ONE.2023; 18(7): e0288671.     CrossRef
  • Meta-analysis of diagnostic accuracy of nucleic acid amplification tests for abdominal tuberculosis
    Yanqin Shen, Likui Fang, Bo Ye, Guocan Yu, Kamal Kishore Chopra
    PLOS ONE.2023; 18(11): e0289336.     CrossRef
  • Chapitre 7: La tuberculose extrapulmonaire
    Leila Barss, William J. A. Connors, Dina Fisher
    Canadian Journal of Respiratory, Critical Care, and Sleep Medicine.2023; 7(6): 365.     CrossRef
  • Recent updates in diagnosis of abdominal tuberculosis with emphasis on nucleic acid amplification tests
    Preeti Mor, Bhawna Dahiya, Sanjeev Parshad, Pooja Gulati, Promod K. Mehta
    Expert Review of Gastroenterology & Hepatology.2022; 16(1): 33.     CrossRef
  • Chapter 7: Extra-pulmonary tuberculosis
    Leila Barss, William J. A. Connors, Dina Fisher
    Canadian Journal of Respiratory, Critical Care, and Sleep Medicine.2022; 6(sup1): 87.     CrossRef
  • Abdominal Tuberculosis Mimicking Ovarian Cancer: A Case Report and Review of the Literature
    Ikhwan Rinaldi, Abdul Muthalib, Djaja Gosal, Teguh Wijayadi, Barlian Sutedja, Tjondro Setiawan, Andika Gunawan, Nelly Susanto, Lingga Magdalena, Diah Rini Handjari, Fetisari Kurniawan, Aisyah Rifani, Kevin Winston
    International Medical Case Reports Journal.2022; Volume 15: 169.     CrossRef
  • Intestinal Tuberculosis Presenting with Gastrointestinal Bleeding in Patient on Warfarin Therapy
    Werimo Pascal Kuka, Joe Rakiro, Joseph Gatheru, Felix Riunga, Allan Rajula, Daniel C. Damin
    Case Reports in Gastrointestinal Medicine.2022; 2022: 1.     CrossRef
  • Evaluating diagnostic performance of Truenat MTB Plus for gastrointestinal tuberculosis
    Kusum Sharma, Megha Sharma, Vishal Sharma, Megha Sharma, Jayanta Samanta, Aman Sharma, Rakesh Kochhar, Saroj Kant Sinha
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1571.     CrossRef
  • Totally laparoscopic treatment of intestinal tuberculosis complicated with bowel perforation: The first case report in worldwide literature with a brief review
    Giuseppe Di Buono, Roberta Vella, Giuseppe Amato, Giorgio Romano, Vito Rodolico, Marta Saverino, Giovanni De Lisi, Giorgio Romano, Salvatore Buscemi, Antonino Agrusa
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Acid fast bacillus smear, mycobacterial culture and Xpert MTB/RIF assay for the diagnosis of tuberculous peritonitis in patients with and without end stage renal failure
    Richa Misra, Mitra Kar, Samir Mohindra, Amit Gupta
    Access Microbiology .2022;[Epub]     CrossRef
  • Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis
    Vishal Sharma, Hariom Soni, Praveen Kumar-M, Saurabh Dawra, Shubhra Mishra, Harshal S Mandavdhare, Harjeet Singh, Usha Dutta
    Expert Review of Anti-infective Therapy.2021; 19(2): 253.     CrossRef
  • Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults
    Mikashmi Kohli, Ian Schiller, Nandini Dendukuri, Mandy Yao, Keertan Dheda, Claudia M Denkinger, Samuel G Schumacher, Karen R Steingart
    Cochrane Database of Systematic Reviews.2021;[Epub]     CrossRef
  • Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2021; 5(2): 177.     CrossRef
  • Application value of tissue tuberculosis antigen combined with Xpert MTB/RIF detection in differential diagnoses of intestinal tuberculosis and Crohn’s disease
    Baoying Fei, Lin Zhou, Yu Zhang, Linhe Luo, Yuanyuan Chen
    BMC Infectious Diseases.2021;[Epub]     CrossRef
  • Gastrointestinal tuberculosis
    Adnan B. Al-Zanbagi, M. K. Shariff
    Saudi Journal of Gastroenterology.2021; 27(5): 261.     CrossRef
  • A combination of circulating microRNA-375-3p and chemokines CCL11, CXCL12, and G-CSF differentiate Crohn’s disease and intestinal tuberculosis
    Susree Roy, Suchandrima Ghosh, Mallica Banerjee, Sayantan Laha, Dipanjan Bhattacharjee, Rajib Sarkar, Sujay Ray, Arko Banerjee, Ranajoy Ghosh, Aniket Halder, Alakendu Ghosh, Raghunath Chatterjee, Simanti Datta, Gopal Krishna Dhali, Soma Banerjee
    Scientific Reports.2021;[Epub]     CrossRef
  • An Outcome-Based Composite Approach for the Diagnosis of Intestinal Tuberculosis: A Pilot Study from a Tertiary Care Centre in South India
    Roopa Rachel Paulose, V Anil Kumar, Aparna Sharma, Aditi Damle, Divya Saikumar, Abish Sudhakar, Anoop K Koshy, Rama P Venu
    Journal of the Royal College of Physicians of Edinburgh.2021; 51(4): 344.     CrossRef
  • Abdominal Tuberculosis in Children: Challenges, Uncertainty, and Confusion
    Giulia Sartoris, James A Seddon, Helena Rabie, Etienne D Nel, H Simon Schaaf
    Journal of the Pediatric Infectious Diseases Society.2020; 9(2): 218.     CrossRef
  • How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study
    Christopher Lowbridge, Soraya A. M. Fadhil, Gayathri D. Krishnan, Emma Schimann, Raman Muthu Karuppan, Nagaraj Sriram, Giri Shan Rajahram, Jayaram Menon, Aatish Patel, Timothy William, Dawn Carmel Paul, Anna P. Ralph
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Abdominal Tuberculosis Mimicking Ovarian Cancer: A Diagnostic Dilemma
    Anitha Thomas, Ajit Sebastian, Rachel George, Dhanya Susan Thomas, Grace Rebekah, Priscila Rupali, Joy Sarojini Michael, Abraham Peedicayil
    The Journal of Obstetrics and Gynecology of India.2020; 70(4): 304.     CrossRef
  • Apoptosis in peripheral blood lymphocytes in intestinal tuberculosis and Crohn’s disease: Implications to diagnostic differentiation
    Suprabha Suresh Nayak, Mamatha Vishwanatha Shetty, Cannanore Ganesh Pai, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy
    Indian Journal of Gastroenterology.2020; 39(4): 338.     CrossRef
  • Multiplex Polymerase Chain Reaction for diagnosis of gastrointestinal tuberculosis
    Sarthak Malik, Kusum Sharma, Kim Vaiphei, Narendra Dhaka, Neha Berry, Pankaj Gupta, Megha Sharma, Bipadabhanjan Mallick, Rakesh Kochhar, Saroj K Sinha
    JGH Open.2019; 3(1): 32.     CrossRef
  • Differentiating Crohn’s disease from intestinal tuberculosis
    Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja
    World Journal of Gastroenterology.2019; 25(4): 418.     CrossRef
  • Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers
    Balaji L Bellam, Harshal S Mandavdhare, Kusum Sharma, Siddharth Shukla, Hariom Soni, Praveen Kumar-M, Harjeet Singh, Kaushal K Prasad, Usha Dutta, Vishal Sharma
    Therapeutic Advances in Infectious Disease.2019; 6: 204993611986393.     CrossRef
  • GeneXpert in stool: Diagnostic yield in Intestinal Tuberculosis
    Abu Talib, Shaheen Bhatty, Khalid Mehmood, Huda Naim, Iftikhar Haider, Hari Lal, Gohar Ali, Muhammad Nashit
    Journal of Clinical Tuberculosis and Other Mycobacterial Diseases.2019; 17: 100131.     CrossRef
  • GENEXPERT FOR ABDOMINAL TUBERCULOSIS
    Alka SHARMA
    Arquivos de Gastroenterologia.2019; 56(4): 454.     CrossRef
  • A diagnostic approach for differentiating abdominal tuberculosis from ovarian malignancy: a case series and literature review
    Moh Nailul Fahmi, Annisaa Pelita Harti
    BMC Proceedings.2019;[Epub]     CrossRef
  • Xpert®MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance
    Mikashmi Kohli, Ian Schiller, Nandini Dendukuri, Keertan Dheda, Claudia M Denkinger, Samuel G Schumacher, Karen R Steingart
    Cochrane Database of Systematic Reviews.2018;[Epub]     CrossRef
  • Surgery for Abdominal Tuberculosis in the Present Era: Experience from a Tertiary-Care Center
    Harjeet Singh, Gautham Krishnamurthy, Jayapal Rajendran, Vishal Sharma, Harshal Mandavdhare, Hemanth Kumar, Thakur Deen Yadav, Rakesh Kumar Vasishta, Rajinder Singh
    Surgical Infections.2018; 19(6): 640.     CrossRef
  • Making a Positive Diagnosis of Intestinal Tuberculosis with the Aid of New Biologic and Histologic Features: How Far Have We Reached?
    Vatsal Mehta, Devendra Desai, Philip Abraham, Camilla Rodrigues
    Inflammatory Intestinal Diseases.2018; 3(4): 155.     CrossRef
  • Editor’s Pick: Recent Advances in the Diagnosis and Management of Abdominal Tuberculosis
    Harshal S. Mandavdhare, Harjeet Singh, Vishal Sharma
    EMJ Gastroenterology.2017; : 52.     CrossRef
  • 6,486 View
  • 95 Download
  • 30 Web of Science
  • 33 Crossref
Close layer
Systematic Review
Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis
Saurabh Kedia, Raju Sharma, Vishnubhatla Sreenivas, Kumble Seetharama Madhusudhan, Vishal Sharma, Sawan Bopanna, Venigalla Pratap Mouli, Rajan Dhingra, Dawesh Prakash Yadav, Govind Makharia, Vineet Ahuja
Intest Res 2017;15(2):149-159.   Published online April 27, 2017
DOI: https://doi.org/10.5217/ir.2017.15.2.149
AbstractAbstract PDFPubReaderePub

Abdominal computed tomography (CT) can noninvasively image the entire gastrointestinal tract and assess extraintestinal features that are important in differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB). The present meta-analysis pooled the results of all studies on the role of CT abdomen in differentiating between CD and ITB. We searched PubMed and Embase for all publications in English that analyzed the features differentiating between CD and ITB on abdominal CT. The features included comb sign, necrotic lymph nodes, asymmetric bowel wall thickening, skip lesions, fibrofatty proliferation, mural stratification, ileocaecal area, long segment, and left colonic involvements. Sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio (DOR) were calculated for all the features. Symmetric receiver operating characteristic curve was plotted for features present in >3 studies. Heterogeneity and publication bias was assessed and sensitivity analysis was performed by excluding studies that compared features on conventional abdominal CT instead of CT enterography (CTE). We included 6 studies (4 CTE, 1 conventional abdominal CT, and 1 CTE+conventional abdominal CT) involving 417 and 195 patients with CD and ITB, respectively. Necrotic lymph nodes had the highest diagnostic accuracy (sensitivity, 23%; specificity, 100%; DOR, 30.2) for ITB diagnosis, and comb sign (sensitivity, 82%; specificity, 81%; DOR, 21.5) followed by skip lesions (sensitivity, 86%; specificity, 74%; DOR, 16.5) had the highest diagnostic accuracy for CD diagnosis. On sensitivity analysis, the diagnostic accuracy of other features excluding asymmetric bowel wall thickening remained similar. Necrotic lymph nodes and comb sign on abdominal CT had the best diagnostic accuracy in differentiating CD and ITB.

Citations

Citations to this article as recorded by  
  • Differentiation of Crohn's disease, ulcerative colitis, and intestinal tuberculosis by dual-layer spectral detector CT enterography
    M. Huang, L. Tu, J. Li, X. Yue, L. Wu, M. Yang, Y. Chen, P. Han, X. Li, L. Zhu
    Clinical Radiology.2024; 79(3): e482.     CrossRef
  • Deep Learning Radiomics Analysis of CT Imaging for Differentiating Between Crohn’s Disease and Intestinal Tuberculosis
    Ming Cheng, Hanyue Zhang, Wenpeng Huang, Fei Li, Jianbo Gao
    Journal of Imaging Informatics in Medicine.2024; 37(4): 1516.     CrossRef
  • New diagnostic strategies to distinguish Crohn's disease and gastrointestinal tuberculosis
    Himanshu Narang, Saurabh Kedia, Vineet Ahuja
    Current Opinion in Infectious Diseases.2024; 37(5): 392.     CrossRef
  • Management and monitoring of pediatric inflammatory bowel disease in the Asia‐Pacific region: A position paper by the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group: Surgical management,
    Way Seah Lee, Katsuhiro Arai, George Alex, Suporn Treepongkaruna, Kyung Mo Kim, Chee Liang Choong, Karen Calixto Mercado, Andy Darma, Anshu Srivastava, Marion M. Aw
    Journal of Gastroenterology and Hepatology.2023; 38(4): 510.     CrossRef
  • Granulomatous bowel disease: Crohn’s disease and tuberculosis. Difficulties in differential diagnosis (case report and review)
    A. V. Vardanyan, E. S. Merkulova, V. A. Belinskaya, K. S. Frolova, O. A. Mainovskaya
    Koloproktologia.2023; 22(1): 117.     CrossRef
  • Evidence-based approach to diagnosis and management of abdominal tuberculosis
    Daya Krishna Jha, Mythili Menon Pathiyil, Vishal Sharma
    Indian Journal of Gastroenterology.2023; 42(1): 17.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Recent updates in diagnosis of abdominal tuberculosis with emphasis on nucleic acid amplification tests
    Preeti Mor, Bhawna Dahiya, Sanjeev Parshad, Pooja Gulati, Promod K. Mehta
    Expert Review of Gastroenterology & Hepatology.2022; 16(1): 33.     CrossRef
  • Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis
    Saurabh Kedia, Raju Sharma, Sudheer Kumar Vuyyuru, Deepak Madhu, Pabitra Sahu, Bhaskar Kante, Prasenjit Das, Ankur Goyal, Karan Madan, Govind Makharia, Vineet Ahuja
    Intestinal Research.2022; 20(2): 184.     CrossRef
  • Systematic reporting of computed tomography enterography/enteroclysis as an aid to reduce diagnostic dilemma when differentiating between intestinal tuberculosis and Crohn's disease: A prospective study at a tertiary care hospital
    Amrin Israrahmed, Rajanikant R Yadav, Geeta Yadav, Alpana, Rajesh V Helavar, Praveer Rai, Manoj Kumar Jain, Archna Gupta
    JGH Open.2021; 5(2): 180.     CrossRef
  • Intestinal Tuberculosis: A Diagnostic Challenge
    Hansang Park, Tikal Kansara, Ana M Victoria, Noella Boma, Jungrak Hong
    Cureus.2021;[Epub]     CrossRef
  • Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2021; 5(2): 177.     CrossRef
  • Deep‐learning system for real‐time differentiation between Crohn's disease, intestinal Behçet's disease, and intestinal tuberculosis
    Jung Min Kim, Jun Gu Kang, Sungwon Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2021; 36(8): 2141.     CrossRef
  • Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease
    Ritika Rampal, Saurabh Kedia, Mohamad Nahidul Wari, Deepak Madhu, Amit Kumar Singh, Veena Tiwari, V. Pratap Mouli, Srikant Mohta, Govind Makharia, Vineet Ahuja
    Intestinal Research.2021; 19(2): 232.     CrossRef
  • Correlation-driven framework based on graph convolutional network for clinical disease classification
    Kai Cao, Ying Xiao, Muzhou Hou
    Journal of Statistical Computation and Simulation.2021; 91(15): 3108.     CrossRef
  • Difficulties in the differential diagnosis of intestinal tuberculosis and Crohn‘s disease
    M. N. Reshetnikov, D. V. Plotkin, Yu. R. Zyuzya, A. A. Volkov, O. N. Zuban, E. M. Bogorodskaya
    Acta Biomedica Scientifica.2021; 6(5): 196.     CrossRef
  • Diagnostic performance of CT for differentiating peritoneal tuberculosis from peritoneal carcinomatosis: a systematic review and meta-analysis
    J. Chen, S. Liu, Y. Tang, X. Zhang, M. Cao, Z. Xiao, M. Ren, T. Chen
    Clinical Radiology.2020; 75(5): 396.e7.     CrossRef
  • Disseminated tuberculosis presenting as massive lower gastrointestinal bleeding
    Nehal Aggarwal, SubodhKumar Mahto, Akanskha Singh, Kritika Gupta, Ankita Aneja, Anu Singh, Atul Goel
    Journal of Family Medicine and Primary Care.2020; 9(2): 1226.     CrossRef
  • Differentiating Crohn’s disease from intestinal tuberculosis
    Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja
    World Journal of Gastroenterology.2019; 25(4): 418.     CrossRef
  • The potential role of CT enterography and gastrointestinal ultrasound in the evaluation of anti-tubercular therapy response of intestinal tuberculosis: a retrospective study
    Li Ma, Qingli Zhu, Yue Li, Wenbo Li, Xuan Wang, Wei Liu, Jianchu Li, Yuxin Jiang
    BMC Gastroenterology.2019;[Epub]     CrossRef
  • Indian guidelines on imaging of the small intestine in Crohn’s disease: A joint Indian Society of Gastroenterology and Indian Radiology and Imaging Association consensus statement
    Saurabh Kedia, Raju Sharma, Govind Makharia, Vineet Ahuja, Devendra Desai, Devasenathipathy Kandasamy, Anu Eapen, Karthik Ganesan, Uday C Ghosha, Naveen Kalra, R Karthikeyan, Kumble Seetharama Madhusudhan, Mathew Philip, Amarender Puri, Sunil Puri, Saroj
    Indian Journal of Radiology and Imaging.2019; 29(02): 111.     CrossRef
  • Imaging in discriminating intestinal tuberculosis and Crohn’s disease: past, present and the future
    Pradeep Goyal, Jimil Shah, Sonali Gupta, Pankaj Gupta, Vishal Sharma
    Expert Review of Gastroenterology & Hepatology.2019; 13(10): 995.     CrossRef
  • Combination of increased visceral fat and long segment involvement: Development and validation of an updated imaging marker for differentiating Crohn's disease from intestinal tuberculosis
    Saurabh Kedia, Kumble S Madhusudhan, Raju Sharma, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Prasenjit Das, Siddhartha Dattagupta, Govind Makharia, Vineet Ahuja
    Journal of Gastroenterology and Hepatology.2018; 33(6): 1234.     CrossRef
  • Computed Tomography Enterography: Quantitative Evaluation on Crohn’s Disease Activity
    Jingyun Cheng, Hui Xie, Hao Yang, Ke Wang, Guobin Xu, Guangyao Wu
    Gastroenterology Research and Practice.2018; 2018: 1.     CrossRef
  • Gastrointestinal Tuberculosis Presenting as Malnutrition and Distal Colonic Bowel Obstruction
    Raja Chandra Chakinala, Zahava C. Farkas, Benjamin Barbash, Khwaja F. Haq, Shantanu Solanki, Muhammad Ali Khan, Edward Esses, Taliya Farooq, Brad Dworkin
    Case Reports in Gastrointestinal Medicine.2018; 2018: 1.     CrossRef
  • Diagnostic point-of-care ultrasound (POCUS) for gastrointestinal pathology: state of the art from basics to advanced
    Fikri M Abu-Zidan, Arif Alper Cevik
    World Journal of Emergency Surgery.2018;[Epub]     CrossRef
  • Enfermedad de Crohn vs tuberculosis intestinal: un diagnóstico diferencial desafiante. Revisión de tema
    Gabriel Alonso Mosquera-Klinger, Andrea Ucroz Benavides
    Revista Colombiana de Gastroenterología.2018; 33(4): 423.     CrossRef
  • Imaging of the small intestine in Crohn’s disease: Joint position statement of the Indian Society of Gastroenterology and Indian Radiological and Imaging Association
    Saurabh Kedia, Raju Sharma, Govind K. Makharia, Vineet Ahuja, Devendra Desai, Devasenathipathy Kandasamy, Anu Eapen, Karthik Ganesan, Uday C. Ghoshal, Naveen Kalra, D. Karthikeyan, Kumble Seetharama Madhusudhan, Mathew Philip, Amarender Singh Puri, Sunil
    Indian Journal of Gastroenterology.2017; 36(6): 487.     CrossRef
  • Editor’s Pick: Recent Advances in the Diagnosis and Management of Abdominal Tuberculosis
    Harshal S. Mandavdhare, Harjeet Singh, Vishal Sharma
    EMJ Gastroenterology.2017; : 52.     CrossRef
  • 8,112 View
  • 137 Download
  • 27 Web of Science
  • 29 Crossref
Close layer
Original Article
Prevalence of hepatitis B, hepatitis C and human immunodeficiency viral infections in patients with inflammatory bowel disease in north India
Parnita Harsh, Vipin Gupta, Saurabh Kedia, Sawan Bopanna, Sucharita Pilli, Surendernath, Govind Kumar Makharia, Vineet Ahuja
Intest Res 2017;15(1):97-102.   Published online January 31, 2017
DOI: https://doi.org/10.5217/ir.2017.15.1.97
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Patients with inflammatory bowel disease (IBD) often require immunosuppressive therapy and blood transfusions and therefore are at a high risk of contracting infections due to hepatitis B (HBV) and hepatitis C (HCV) and human immunodeficiency virus (HIV). In the present study, we assessed the prevalence of these infections in patients with IBD.

Methods

This retrospective study included 908 consecutive patients with IBD (ulcerative colitis [UC], n=581; Crohn's disease [CD], n=327) who were receiving care at a tertiary care center. Ninety-five patients with intestinal tuberculosis (ITB) were recruited as disease controls. Prospectively maintained patient databases were reviewed for the prevalence of HBV surface antigen, anti-HCV antibodies, and HIV (enzyme-linked immunosorbent assay method). HCV RNA was examined in patients who tested positive for anti-HCV antibodies. Prevalence data of the study were compared with that of the general Indian population (HBV, 3.7%; HCV, 1%; HIV, 0.3%).

Results

The prevalence of HBV, HCV, and HIV was 2.4%, 1.4%, and 0.1%, respectively, in the 908 patients with IBD. Among the 581 patients with UC, 2.2% (12/541) had HBV, 1.7% (9/517) had HCV, and 0.2% (1/499) had HIV. Among the 327 patients with CD, 2.8% (8/288) had HBV, 0.7% (2/273) had HCV, and 0% (0/277) had HIV. One patient with CD had HBV and HCV coinfection. The prevalence of HBV, HCV, and HIV in patients with ITB was 5.9% (4/67), 1.8% (1/57), and 1.2% (1/84), respectively.

Conclusions

The prevalence of HBV, HCV, and HIV in north Indian patients with IBD is similar to the prevalence of these viruses in the general community. Nonetheless, the high risk of flare after immunosuppressive therapy mandates routine screening of patients with IBD for viral markers.

Citations

Citations to this article as recorded by  
  • Managing IBD Patients with Concomitant HIV Infection - a Systematic Review
    Hugo Sousa, Joana Barroso, Raquel Tavares, Joana Torres
    Current Gastroenterology Reports.2024; 26(1): 1.     CrossRef
  • Brucellosis in a patient with Crohn's disease treated with infliximab: A case report
    Mansour Altuwaijri, Nasser Alkhraiji, Mosaab Almasry, Saad Alkhowaiter, Nuha Al Amaar, Ammar Alotaibi
    Arab Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Prevalence of hepatitis B virus and hepatitis C virus infection in patients with inflammatory bowel disease: a systematic review and meta-analysis
    Suprabhat Giri, Dhiraj Agrawal, Shivaraj Afzalpurkar, Sunil Kasturi, Amrit Gopan, Sridhar Sundaram, Aditya Kale
    Intestinal Research.2023; 21(3): 392.     CrossRef
  • Expert consensus on vaccination in patients with inflammatory bowel disease in Japan
    Takashi Ishige, Toshiaki Shimizu, Kenji Watanabe, Katsuhiro Arai, Koichi Kamei, Takahiro Kudo, Reiko Kunisaki, Daisuke Tokuhara, Makoto Naganuma, Tatsuki Mizuochi, Atsuko Murashima, Yuta Inoki, Naomi Iwata, Itaru Iwama, Sachi Koinuma, Hirotaka Shimizu, Ke
    Journal of Gastroenterology.2023; 58(2): 135.     CrossRef
  • Prevalence of viral hepatitis infection in India: A systematic review and meta-analysis
    Dhasarathi Kumar, Roshni M. Peter, Alex Joseph, Kalpana Kosalram, Harpreet Kaur
    Journal of Education and Health Promotion.2023;[Epub]     CrossRef
  • Frequency of hepatitis C virus infection in patients with pediatric inflammatory bowel disease: a cross-sectional study
    Sara Tarek, Ayman E. Eskander, Safa Meshaal, Eman Badr, Asmaa Abd El-Hakeem
    Egyptian Pediatric Association Gazette.2023;[Epub]     CrossRef
  • Pancreatic Disorders in Patients with Inflammatory Bowel Disease
    Marilia L. Montenegro, Juan E. Corral, Frank J. Lukens, Baoan Ji, Paul T. Kröner, Francis A. Farraye, Yan Bi
    Digestive Diseases and Sciences.2022; 67(2): 423.     CrossRef
  • Vaccination strategies for Korean patients with inflammatory bowel disease
    Yoo Jin Lee, Eun Soo Kim
    The Korean Journal of Internal Medicine.2022; 37(5): 920.     CrossRef
  • Viral Hepatitis in Patients with Inflammatory Bowel Disease
    Seung Hwan Shin, Sang Hyoung Park
    The Korean Journal of Gastroenterology.2022; 80(2): 51.     CrossRef
  • Involvement of HHV-4 (Epstein–Barr Virus) and HHV-5 (Cytomegalovirus) in Inflammatory Bowel Disease and Colorectal Cancer: A Meta-Analysis
    Luigi Marongiu, Sascha Venturelli, Heike Allgayer
    Cancers.2022; 14(20): 5085.     CrossRef
  • Prevalence of serological markers of hepatitis B in inflammatory bowel disease – Experience from a tertiary care centre in South India
    Amol Prabhakar Patil, Ebby George Simon, Amit Kumar Dutta, Anjilivelil Joseph Joseph, Reuben Thomas Kurien, Sudipta Dhar Chowdhury
    Tropical Doctor.2021; 51(3): 326.     CrossRef
  • Comorbidity before and after a diagnosis of inflammatory bowel disease
    Charles N. Bernstein, Zoann Nugent, Seth Shaffer, Harminder Singh, Ruth Ann Marrie
    Alimentary Pharmacology & Therapeutics.2021; 54(5): 637.     CrossRef
  • ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease
    T Kucharzik, P Ellul, T Greuter, J F Rahier, B Verstockt, C Abreu, A Albuquerque, M Allocca, M Esteve, F A Farraye, H Gordon, K Karmiris, U Kopylov, J Kirchgesner, E MacMahon, F Magro, C Maaser, L de Ridder, C Taxonera, M Toruner, L Tremblay, M Scharl, N
    Journal of Crohn's and Colitis.2021; 15(6): 879.     CrossRef
  • Management of hepatitis B virus infection in patients with inflammatory bowel disease under immunosuppressive treatment
    Georgios Axiaris, Evanthia Zampeli, Spyridon Michopoulos, Giorgos Bamias
    World Journal of Gastroenterology.2021; 27(25): 3762.     CrossRef
  • Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia
    Rupa Banerjee, Partha Pal, Joyce Wing Yan Mak, Siew C Ng
    The Lancet Gastroenterology & Hepatology.2020; 5(12): 1076.     CrossRef
  • Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
    Seong Jae Yeo, Hyun Seok Lee, Byung Ik Jang, Eun Soo Kim, Seong Woo Jeon, Sung Kook Kim, Kyeong Ok Kim, Yoo Jin Lee, Hyun Jik Lee, Kyung Sik Park, Yun Jin Jung, Eun Young Kim, Chang Heon Yang
    Intestinal Research.2018; 16(3): 400.     CrossRef
  • Inflammatory bowel disease is no longer a risk factor of viral hepatitis infection in Asia
    Eun Soo Kim
    Intestinal Research.2017; 15(1): 5.     CrossRef
  • 5,616 View
  • 52 Download
  • 15 Web of Science
  • 17 Crossref
Close layer
Brief Communication
Pivot to Asia: inflammatory bowel disease burden
Prashant Singh, Ashwin Ananthakrishnan, Vineet Ahuja
Intest Res 2017;15(1):138-141.   Published online January 31, 2017
DOI: https://doi.org/10.5217/ir.2017.15.1.138
PDFPubReaderePub

Citations

Citations to this article as recorded by  
  • IBD Card: Promoting continuity in care for patients with inflammatory bowel disease
    Harshavardhan Telaprolu, Anupam K. Singh, Vishal Sharma, Usha Dutta
    Indian Journal of Gastroenterology.2024; 43(1): 7.     CrossRef
  • Perianal fistulizing Crohn’s disease: Current perspectives on diagnosis, monitoring and management with a focus on emerging therapies
    Jalpa Devi, David H. Ballard, Tina Aswani-Omprakash, Alyssa M. Parian, Parakkal Deepak
    Indian Journal of Gastroenterology.2024; 43(1): 48.     CrossRef
  • Clinical factors associated with severity in patients with inflammatory bowel disease in Brazil based on 2-year national registry data from GEDIIB
    Renata de Sá Brito Fróes, Adriana Ribas Andrade, Mikaell Alexandre Gouvea Faria, Heitor Siffert Pereira de Souza, Rogério Serafim Parra, Cyrla Zaltman, Carlos Henrique Marques dos Santos, Mauro Bafutto, Abel Botelho Quaresma, Genoile Oliveira Santana, Raf
    Scientific Reports.2024;[Epub]     CrossRef
  • Risk of tuberculosis with anti-TNF therapy in Indian patients with inflammatory bowel disease despite negative screening
    Suprabhat Giri, Sukanya Bhrugumalla, Akash Shukla, Sagar Gangadhar, Srujan Reddy, Sumaswi Angadi, Leela Shinde, Aditya Kale
    Arab Journal of Gastroenterology.2024;[Epub]     CrossRef
  • Challenges in IBD Research 2024: Environmental Triggers
    Ashwin N Ananthakrishnan, Kostantinos Gerasimidis, Shuk-Mei Ho, Emeran Mayer, Jennifer Pollock, Shefali Soni, Gary D Wu, Jalil Benyacoub, Basmah Ali, Alex Favreau, Denise Elsbree Smith, Ji-eun Oh, Caren Heller, Andres Hurtado-Lorenzo, Alan Moss, Ken Croit
    Inflammatory Bowel Diseases.2024; 30(Supplement): S19.     CrossRef
  • Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment
    Aaron T. Kao, Christian V. Cabanlong, Kendra Padilla, Xiang Xue
    Acta Pharmaceutica Sinica B.2024; 14(9): 3785.     CrossRef
  • Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer.
    Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
    Heliyon.2024; : e33838.     CrossRef
  • Granulomatous inflammation is less common in delayed-onset Crohn's disease
    Madeline Vithya Barnaba Durairaj, Rajeeb Jaleel, Anna B Pulimood
    Tropical Doctor.2023; 53(1): 113.     CrossRef
  • High seroprevalence against SARS-CoV-2 in non-vaccinated patients with inflammatory bowel disease from Northern India
    Bhaskar Kante, Sudheer Kumar Vuyyuru, Ritu Gupta, Tanima Dwivedi, Peeyush Kumar, Sandeep Mundhra, Rithvik Golla, Shubi Virmani, Mahak Verma, Govind Makharia, Vineet Ahuja, Saurabh Kedia
    Indian Journal of Gastroenterology.2023; 42(1): 70.     CrossRef
  • Interferon-gamma release assay has poor diagnostic accuracy in differentiating intestinal tuberculosis from Crohn’s disease in tuberculosis endemic areas
    Karan Sachdeva, Peeyush Kumar, Bhaskar Kante, Sudheer K. Vuyyuru, Srikant Mohta, Mukesh K. Ranjan, Mukesh K. Singh, Mahak Verma, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Intestinal Research.2023; 21(2): 226.     CrossRef
  • Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification
    Alain P. Gobert, Thaddeus M. Smith, Yvonne L. Latour, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Kamery J. Williams, Kara M. McNamara, Alberto G. Delgado, Sarah P. Short, Raghavendra G. Mirmira, Kristie L. Rose, Kevin L. Schey, Irene Zagol-Ikapi
    Gastroenterology.2023; 165(3): 656.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Colon-Adhering Delivery System with Inflammation Responsiveness for Localized Therapy of Experimental Colitis
    Ajay Kumar, Kanika, Vibhu Kumar, Anas Ahmad, Rakesh Kumar Mishra, Ahmed Nadeem, Nahid Siddiqui, Md Meraj Ansari, Syed Shadab Raza, Kanthi Kiran Kondepudi, Rehan Khan
    ACS Biomaterials Science & Engineering.2023; 9(8): 4781.     CrossRef
  • Diagnosis of inflammatory bowel disease–Asian perspectives: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
    Han Hee Lee, Jae Jun Park, Bo-In Lee, Ida Hilmi, Jose Sollano, Zhi Hua Ran
    Intestinal Research.2023; 21(3): 328.     CrossRef
  • Synthesis of some Curcumin derivatives of Non-Steroidal Anti-Inflammatory (NSAIDs) Prodrugs for Treatment of Inflammatory Bowel Diseases
    Yogendra Kumar, Nidhi Agrawal, Meenakshi Jaiswal
    Research Journal of Pharmacy and Technology.2023; : 2733.     CrossRef
  • Inflammatory Bowel Disease and X (Formerly Twitter) Influencers: Who Are They and What Do They Say?
    Ayushi Garg, Aalam Sohal, Shivam Kalra, Carol Singh, Ishandeep Singh, Jasneet Grewal, Rohin Kansal, Kashish Malhotra, Ramit Mahajan, Vandana Midha, Arshdeep Singh, Ajit Sood, Ashvind Bawa
    Cureus.2023;[Epub]     CrossRef
  • Thiopurines Have Sustained Long-term Effectiveness in Patients with Inflammatory Bowel Disease, Which is Independent of Disease Duration at Initiation: A Propensity Score Matched Analysis
    Mukesh Kumar Ranjan, Peeyush Kumar, Sudheer Kumar Vuyyuru, Bhaskar Kante, Sandeep K Mundhra, Rithvik Golla, Shubi Virmani, Raju Sharma, Peush Sahni, Prasenjit Das, Mani Kalaivani, Ashish Datt Upadhyay, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Journal of Crohn's and Colitis.2023;[Epub]     CrossRef
  • Protective Role of Spermidine in Colitis and Colon Carcinogenesis
    Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Jordan L. Finley, Thaddeus M. Smith, Kara M. McNamara, Kshipra Singh, Johanna C. Sierra, Alberto G. Delgado, Paula B. Luis, Claus Schneider, M. Kay Washington, M. Blan
    Gastroenterology.2022; 162(3): 813.     CrossRef
  • Geosocial Features and Loss of Biodiversity Underlie Variable Rates of Inflammatory Bowel Disease in a Large Developing Country: A Population-Based Study
    Andre da Luz Moreira, Luiz Felipe de Campos Lobato, Jessica Pronestino de Lima Moreira, Ronir Raggio Luiz, Celeste Elia, Claudio Fiocchi, Heitor Siffert Pereira de Souza
    Inflammatory Bowel Diseases.2022; 28(11): 1696.     CrossRef
  • Stringent screening strategy significantly reduces reactivation rates of tuberculosis in patients with inflammatory bowel disease on anti‐TNF therapy in tuberculosis endemic region
    Peeyush Kumar, Sudheer K. Vuyyuru, Bhaskar Kante, Pabitra Sahu, Sandeep Goyal, Deepak Madhu, Saransh Jain, Mukesh Kumar Ranjan, Sandeep Mundhra, Rithvik Golla, Mukesh Singh, Shubi Virmani, Anvita Gupta, Nidhi Yadav, Mani Kalaivani, Raju Sharma, Prasenjit
    Alimentary Pharmacology & Therapeutics.2022; 55(11): 1431.     CrossRef
  • Differential colitis susceptibility of Th1- and Th2-biased mice: A multi-omics approach
    Sohini Mukhopadhyay, Subha Saha, Subhayan Chakraborty, Punit Prasad, Arindam Ghosh, Palok Aich, Lili Chen
    PLOS ONE.2022; 17(3): e0264400.     CrossRef
  • Genome-wide DNA methylation profiling in differentiating Crohn’s disease from intestinal tuberculosis
    Hao Wu, Hongchun Liu, Haining Liu, Yanjie Chen, Taotao Liu, Xizhong Shen, Lili Liu
    Genes & Genomics.2022; 44(5): 603.     CrossRef
  • Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis
    Saurabh Kedia, Raju Sharma, Sudheer Kumar Vuyyuru, Deepak Madhu, Pabitra Sahu, Bhaskar Kante, Prasenjit Das, Ankur Goyal, Karan Madan, Govind Makharia, Vineet Ahuja
    Intestinal Research.2022; 20(2): 184.     CrossRef
  • Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?
    Sang Hyoung Park
    Intestinal Research.2022; 20(2): 159.     CrossRef
  • Minimal risk of lymphoma and non‐melanoma skin cancer despite long‐term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India
    Mukesh Kumar Ranjan, Bhaskar Kante, Sudheer Kumar Vuyyuru, Peeyush Kumar, Sandeep K Mundhra, Rithvik Golla, Raju Sharma, Peush Sahni, Prasenjit Das, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1544.     CrossRef
  • Does the road to primary prevention of inflammatory bowel disease start from childhood?
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2022; 6(6): 365.     CrossRef
  • Applying logistic LASSO regression for the diagnosis of atypical Crohn's disease
    Ying Li, Fanggen Lu, Yani Yin
    Scientific Reports.2022;[Epub]     CrossRef
  • Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial
    Saurabh Kedia, Shubi Virmani, Sudheer K Vuyyuru, Peeyush Kumar, Bhaskar Kante, Pabitra Sahu, Kanav Kaushal, Mariyam Farooqui, Mukesh Singh, Mahak Verma, Aditya Bajaj, Manasvini Markandey, Karan Sachdeva, Prasenjit Das, Govind K Makharia, Vineet Ahuja
    Gut.2022; 71(12): 2401.     CrossRef
  • Thromboembolism is associated with poor prognosis and high mortality in patients with inflammatory bowel disease: A case–control study
    Yadukrishna S., Saurabh Kedia, Varun Teja, Sudheer Kumar Vuyyuru, Nidhi Yadav, Pabitra Sahu, Saransh Jain, Dawesh P. Yadav, Sawan Bopanna, Venigalla Pratap Mouli, Deepak Madhu, Raju Sharma, Prasenjit Das, Govind Makharia, Vineet Ahuja
    Indian Journal of Gastroenterology.2022;[Epub]     CrossRef
  • INCIDENCE OF INFLAMMATORY BOWEL DISEASE: A SINGLE CENTRE RETROSPECTIVE STUDY
    Ajay Kumar OLI, Rohit N MAIDUR, Preetham S HURKADLI, Anita P JAVALGI, Palaksha Kanive JAVAREGOWDA, Mallikarjun GONI
    Arquivos de Gastroenterologia.2022; 59(3): 345.     CrossRef
  • Development and Validation of a Smartphone Application for Telenutrition in Patients with Inflammatory Bowel Disease
    Arti Gupta, Namrata Singh, Divya Madan, Mariyam Farooqui, Neha Singh, David Mathew Thomas, Bhaskar Kante, Mukesh Singh, Shubi Virmani, Mehak Verma, Aditya Bajaj, Manasvini Markandey, Peeyush Kumar, Sudheer Kumar Vuyyuru, Pabitra Sahu, Nitika Monga, Govind
    Diagnostics.2022; 12(10): 2482.     CrossRef
  • Protective Effect of Perilla Oil Against Dextran Sodium Sulfate-Induced Colitis in Mice Challenged with a High-Fat Diet
    Shalom Sara Thomas, Youn-Soo Cha, Kyung-Ah Kim
    Journal of Medicinal Food.2022; 25(11): 1021.     CrossRef
  • Difficulties in differential diagnosis tuberculosis and Crohn's disease. Case report
    Oleg V. Knyazev, Anna V. Kagramanova, Nina A. Fadeeva, Irina G. Pelipas, Albina A. Lishchinskaya, Maria Iu. Zvyaglova, Asfold I. Parfenov
    Consilium Medicum.2022; 24(5): 287.     CrossRef
  • Development and Validation of a Digital Health Platform (IBD NutriCare) for Telenutrition in Patients With Inflammatory Bowel Disease
    Arti Gupta, Namrata Singh, Bhaskar Kante, Divya Madan, Mariyam Farooqui, Neha Singh, Mukesh Singh, Shubi Virmani, Mehak Verma, Aditya Bajaj, Manasvini Markandey, Peeyush Kumar, Sudheer Kumar Vuyyuru, Pabitra Sahu, Govind Makharia, Saurabh Kedia, Vineet Ah
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Inflammatory bowel disease in India: challenges and opportunities
    Alice Snell, Jonathan Segal, Jimmy Limdi, Rupa Banerjee
    Frontline Gastroenterology.2021; 12(5): 390.     CrossRef
  • Incidence and Prevalence of Inflammatory Bowel Disease across Asia
    Jihye Park, Jae Hee Cheon
    Yonsei Medical Journal.2021; 62(2): 99.     CrossRef
  • The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
    Yujin Jeong, Seong Ran Jeon, Hyun Gun Kim, Jung Rock Moon, Tae Hee Lee, Jae Young Jang, Jun-Hyung Cho, Jun Seok Park, Heesu Park, Ki-hun Lee, Jin-Oh Kim, Joon Seong Lee, Bong Min Ko, Suyeon Park
    Intestinal Research.2021; 19(1): 62.     CrossRef
  • Combination of sarcopenia and high visceral fat predict poor outcomes in patients with Crohn’s disease
    Gurasis Boparai, Saurabh Kedia, Devasenathipathy Kandasamy, Raju Sharma, Kumble Seetharama Madhusudhan, Nihar Ranjan Dash, Pabitra Sahu, Sujoy Pal, Peush Sahni, Rajesh Panwar, Sudheer Kumar Vuyyuru, Bhaskar Kante, Davesh P. Yadav, Venigalla Pratap Mouli,
    European Journal of Clinical Nutrition.2021; 75(10): 1491.     CrossRef
  • Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion
    Saurabh Kedia, Vineet Ahuja
    JGH Open.2021; 5(2): 177.     CrossRef
  • Deep‐learning system for real‐time differentiation between Crohn's disease, intestinal Behçet's disease, and intestinal tuberculosis
    Jung Min Kim, Jun Gu Kang, Sungwon Kim, Jae Hee Cheon
    Journal of Gastroenterology and Hepatology.2021; 36(8): 2141.     CrossRef
  • Increased Interleukin-10 Expression by the Inhibition of Ca2+-Activated K+ Channel KCa3.1 in CD4+CD25+ Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model
    Susumu Ohya, Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito
    Journal of Pharmacology and Experimental Therapeutics.2021; 377(1): 75.     CrossRef
  • The Impact of Migration on the Gut Metagenome of South Asian Canadians
    Julia K. Copeland, Gary Chao, Shelley Vanderhout, Erica Acton, Pauline W. Wang, Eric I. Benchimol, Ahmed El-Sohemy, Ken Croitoru, Jennifer L. Gommerman, David S. Guttman
    Gut Microbes.2021;[Epub]     CrossRef
  • Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry
    Ajit Sood, Kirandeep Kaur, Ramit Mahajan, Vandana Midha, Arshdeep Singh, Sarit Sharma, Amarender Singh Puri, Bhabhadev Goswami, Devendra Desai, C. Ganesh Pai, Kiran Peddi, Mathew Philip, Rakesh Kochhar, Sandeep Nijhawan, Shobna Bhatia, N. Sridhara Rao
    Intestinal Research.2021; 19(2): 206.     CrossRef
  • Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease
    Ritika Rampal, Saurabh Kedia, Mohamad Nahidul Wari, Deepak Madhu, Amit Kumar Singh, Veena Tiwari, V. Pratap Mouli, Srikant Mohta, Govind Makharia, Vineet Ahuja
    Intestinal Research.2021; 19(2): 232.     CrossRef
  • A report of nonexistence of the non-Helicobacter pylori Helicobacter species in Iranian patients suffering from inflammatory bowel disease
    Samira Pirmanesh, Nasrin Mirzaei, Masoumeh Azimirad, Abbas Yadegar, John Y. Kao, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
    Folia Microbiologica.2021; 66(5): 751.     CrossRef
  • Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices
    Rohan V Yewale, Kartik Natarajan, Jeyaraj Ubal Dhus, Sarojini Ashok Parameswaran, Kallipatti Ramaswamy Palaniswamy, Doraisamy Babu Vinish, Aravindh Somasundaram, Arulraj Ramakrishnan, Sibithooran Karmegam, Ramaswamy Saraswathy Arun, Ujjani Shankaraiah Man
    JGH Open.2021; 5(11): 1306.     CrossRef
  • Changes in Direct Healthcare Costs before and after the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Jooyoung Lee, Jong Pil Im, Kyungdo Han, Jihye Kim, Hyun Jung Lee, Jaeyoung Chun, Joo Sung Kim
    Gut and Liver.2020; 14(1): 89.     CrossRef
  • Changing Global Epidemiology of Inflammatory Bowel Diseases: Sustaining Health Care Delivery Into the 21st Century
    Ashwin N. Ananthakrishnan, Gilaad G. Kaplan, Siew C. Ng
    Clinical Gastroenterology and Hepatology.2020; 18(6): 1252.     CrossRef
  • Inflammatory Bowel Diseases in South Asian Patients: Underappreciated and Understudied
    Bharati Kochar
    Inflammatory Bowel Diseases.2020;[Epub]     CrossRef
  • Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model
    Seongho Ma, Jiah Yeom, Young-Hee Lim
    Scientific Reports.2020;[Epub]     CrossRef
  • Relapse rate following withdrawal of anti-TNF therapy in patients with inflammatory bowel disease: A real-life cohort from northern India
    Pabitra Sahu, Sudheer K. Vuyyuru, Bhaskar Kante, Ashish Agarwal, Raju Sharma, Prasenjit Das, Rajesh Panwar, Saransh Jain, Sawan Bopanna, Govind Makharia, Saurabh Kedia, Vineet Ahuja
    Indian Journal of Gastroenterology.2020; 39(4): 388.     CrossRef
  • Colitis and Crohn’s Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease
    Ajit Sood, Vineet Ahuja, Vandana Midha, Saroj Kant Sinha, C. Ganesh Pai, Saurabh Kedia, Varun Mehta, Sawan Bopanna, Philip Abraham, Rupa Banerjee, Shobna Bhatia, Karmabir Chakravartty, Sunil Dadhich, Devendra Desai, Manisha Dwivedi, Bhabhadev Goswami, Kir
    Intestinal Research.2020; 18(4): 355.     CrossRef
  • Albumin nano-encapsulation of caffeic acid phenethyl ester and piceatannol potentiated its ability to modulate HIF and NF-kB pathways and improves therapeutic outcome in experimental colitis
    Murtaza M. Tambuwala, Mohammed N. Khan, Paul Thompson, Paul A. McCarron
    Drug Delivery and Translational Research.2019; 9(1): 14.     CrossRef
  • Effectiveness and safety of adalimumab biosimilar in inflammatory bowel disease: A multicenter study
    Nagesh Kamat, Saurabh Kedia, Uday C. Ghoshal, Abhimanyu Nehra, Govind Makharia, Ajit Sood, Vandana Midha, Varun Gupta, Gourdas Choudhuri, Vineet Ahuja
    Indian Journal of Gastroenterology.2019; 38(1): 44.     CrossRef
  • Differentiating Crohn’s disease from intestinal tuberculosis
    Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja
    World Journal of Gastroenterology.2019; 25(4): 418.     CrossRef
  • Higher education, professional occupation, and upper socioeconomic status are associated with lower adherence to medications in patients with inflammatory bowel disease
    Sanjeevani K Tomar, Saurabh Kedia, Namrata Singh, Ashish D Upadhyay, Nagesh Kamat, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Govind Makharia, Vineet Ahuja
    JGH Open.2019; 3(4): 302.     CrossRef
  • Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome
    Kshipra Singh, Alain P. Gobert, Lori A. Coburn, Daniel P. Barry, Margaret Allaman, Mohammad Asim, Paula B. Luis, Claus Schneider, Ginger L. Milne, Helen H. Boone, Meghan H. Shilts, M. Kay Washington, Suman R. Das, M. Blanca Piazuelo, Keith T. Wilson
    Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
  • Impaired neurocognitive and psychomotor performance in patients with inflammatory bowel disease
    Ivana Tadin Hadjina, Piero Marin Zivkovic, Andrija Matetic, Doris Rusic, Marino Vilovic, Diana Bajo, Zeljko Puljiz, Ante Tonkic, Josko Bozic
    Scientific Reports.2019;[Epub]     CrossRef
  • All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance
    Grace B. Hatton, Christine M. Madla, Sarit C. Rabbie, Abdul W. Basit
    International Journal of Pharmaceutics.2018; 548(1): 408.     CrossRef
  • Colonic Crohn’s Disease Is Associated with Less Aggressive Disease Course Than Ileal or Ileocolonic Disease
    Umang Arora, Saurabh Kedia, Prerna Garg, Sawan Bopanna, Saransh Jain, Dawesh P. Yadav, Sandeep Goyal, Vipin Gupta, Peush Sahni, Sujoy Pal, Nihar Ranjan Dash, Kumble Seetharama Madhusudhan, Raju Sharma, Govind Makharia, Vineet Ahuja
    Digestive Diseases and Sciences.2018; 63(6): 1592.     CrossRef
  • Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection
    Alain P. Gobert, Nicole T. Al-Greene, Kshipra Singh, Lori A. Coburn, Johanna C. Sierra, Thomas G. Verriere, Paula B. Luis, Claus Schneider, Mohammad Asim, Margaret M. Allaman, Daniel P. Barry, John L. Cleveland, Christina E. Destefano Shields, Robert A. C
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Combination of increased visceral fat and long segment involvement: Development and validation of an updated imaging marker for differentiating Crohn's disease from intestinal tuberculosis
    Saurabh Kedia, Kumble S Madhusudhan, Raju Sharma, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Prasenjit Das, Siddhartha Dattagupta, Govind Makharia, Vineet Ahuja
    Journal of Gastroenterology and Hepatology.2018; 33(6): 1234.     CrossRef
  • Novel treatments for inflammatory bowel disease
    Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
    The Korean Journal of Internal Medicine.2018; 33(1): 20.     CrossRef
  • Is the emergence of inflammatory bowel disease a prime example of “the third epidemiological transition”?
    Saurabh Kedia, Vineet Ahuja
    Indian Journal of Gastroenterology.2018; 37(3): 183.     CrossRef
  • The importance of immunization in immune-mediated inflammatory disease cannot be overstated
    Sang Hyoung Park
    Intestinal Research.2018; 16(3): 325.     CrossRef
  • Management of inflammatory bowel disease in older persons: evolving paradigms
    Saurabh Kedia, Jimmy K. Limdi, Vineet Ahuja
    Intestinal Research.2018; 16(2): 194.     CrossRef
  • Are Truelove and Witts criteria for diagnosing acute severe colitis relevant for the Indian population? A prospective study
    Saransh Jain, Saurabh Kedia, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Peush Sahni, Sujoy Pal, Nihar Ranjan Dash, Govind Makharia, Simon P. L. Travis, Vineet Ahuja
    Intestinal Research.2018; 16(1): 69.     CrossRef
  • Current Evidence for the Management of Inflammatory Bowel Diseases Using Fecal Microbiota Transplantation
    Seong Ran Jeon, Jocelyn Chai, Christiana Kim, Christine H. Lee
    Current Infectious Disease Reports.2018;[Epub]     CrossRef
  • High risk of tuberculosis during infliximab therapy despite tuberculosis screening in inflammatory bowel disease patients in India
    Ashish Agarwal, Saurabh Kedia, Saransh Jain, Vipin Gupta, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Venigalla Pratap Mouli, Rajan Dhingra, Govind Makharia, Vineet Ahuja
    Intestinal Research.2018; 16(4): 588.     CrossRef
  • Genetics of ulcerative colitis: putting into perspective the incremental gains from Indian studies
    Garima Juyal, Ajit Sood, Vandana Midha, B. K. Thelma
    Journal of Genetics.2018; 97(5): 1493.     CrossRef
  • Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea, 2011–2014: A Nationwide Population-Based Study
    Yoon Suk Jung, Minkyung Han, Won Ho Kim, Sohee Park, Jae Hee Cheon
    Digestive Diseases and Sciences.2017; 62(8): 2102.     CrossRef
  • Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration
    Dawesh P. Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K. Vikram, Raju Sharma, Govind K. Makharia, Vineet Ahuja
    Canadian Journal of Gastroenterology and Hepatology.2017; 2017: 1.     CrossRef
  • Impact of dietary beliefs and practices on patients with inflammatory bowel disease: An observational study from India
    Sanjeevani K Tomar, Saurabh Kedia, Ashish D Upadhyay, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Saransh Jain, Govind Makharia, Vineet Ahuja, Namrata Singh
    JGH Open.2017; 1(1): 15.     CrossRef
  • 8,680 View
  • 103 Download
  • 69 Web of Science
  • 73 Crossref
Close layer
Original Article
Role of random biopsies in surveillance of dysplasia in ulcerative colitis patients with high risk of colorectal cancer
Sawan Bopanna, Maitreyee Roy, Prasenjit Das, S Dattagupta, V Sreenivas, V Pratap Mouli, Saurabh Kedia, Rajan Dhingra, Rajesh Pradhan, N Suraj Kumar, Dawesh P Yadav, Govind Makharia, Vineet Ahuja
Intest Res 2016;14(3):264-269.   Published online June 27, 2016
DOI: https://doi.org/10.5217/ir.2016.14.3.264
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Recent data suggest that the incidence of ulcerative colitis (UC) related colorectal cancer (CRC) in India is similar to that of West. The optimum method for surveillance is still a debate. Surveillance with random biopsies has been the standard of care, but is a tedious process. We therefore undertook this study to assess the yield of random biopsy in dysplasia surveillance.

Methods

Between March 2014 and July 2015, patients of UC attending the Inflammatory Bowel Disease clinic at the All India Institute of Medical Sciences with high risk factors for CRC like duration of disease >15 years and pancolitis, family history of CRC, primary sclerosing cholangitis underwent surveillance colonoscopy for dysplasia. Four quadrant random biopsies at 10 cm intervals were taken (33 biopsies). Two pathologists examined specimens for dysplasia, and the yield of dysplasia was calculated.

Results

Twenty-eight patients were included. Twenty-six of these had pancolitis with a duration of disease greater than 15 years, and two patients had associated primary sclerosing cholangis. No patient had a family history of CRC. The mean age at onset of disease was 28.89±8.73 years and the duration of disease was 19.00±8.78 years. Eighteen patients (64.28%) were males. A total of 924 biopsies were taken. None of the biopsies revealed any evidence of dysplasia, and 7/924 (0.7%) were indefinite for dysplasia.

Conclusions

Random biopsy for surveillance in longstanding extensive colitis has a low yield for dysplasia and does not suffice for screening. Newer techniques such as chromoendoscopy-guided biopsies need greater adoption.

Citations

Citations to this article as recorded by  
  • Etrolizumab as an induction and maintenance therapy for ulcerative colitis: A systematic review and meta‐analysis of randomized controlled trials
    Othman Saleh, Mohamed T. Abuelazm, Islam Mohamed, Alaa Ramadan, Mohammad Assaf, Ahmad Alzoubi, Majd M. AlBarakat, Basel Abdelazeem
    JGH Open.2024;[Epub]     CrossRef
  • Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India
    Arshdeep Singh, Vandana Midha, Vikram Narang, Saurabh Kedia, Ramit Mahajan, Pavan Dhoble, Bhavjeet Kaur Kahlon, Ashvin Singh Dhaliwal, Ashish Tripathi, Shivam Kalra, Narender Pal Jain, Namita Bansal, Rupa Banerjee, Devendra Desai, Usha Dutta, Vineet Ahuja
    Intestinal Research.2023; 21(4): 452.     CrossRef
  • Colorectal Cancer Surveillance in Patients with Inflammatory Bowel Diseases: Chromoendoscopy or Non-Chromoendoscopy, That Is the Question
    Roberto Gabbiadini, Ferdinando D’Amico, Alessandro De Marco, Maria Terrin, Alessandra Zilli, Federica Furfaro, Mariangela Allocca, Gionata Fiorino, Silvio Danese
    Journal of Clinical Medicine.2022; 11(3): 509.     CrossRef
  • Endoscopic Surveillance in Inflammatory Bowel Diseases: Selecting a Suitable Technology
    Arianna Dal Buono, Roberto Gabbiadini, Federica Furfaro, Marjorie Argollo, Thaís Viana Tavares Trigo, Alessandro Repici, Giulia Roda
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Heterogeneity of Colorectal Cancer Progression: Molecular Gas and Brakes
    Federica Gaiani, Federica Marchesi, Francesca Negri, Luana Greco, Alberto Malesci, Gian Luigi de’Angelis, Luigi Laghi
    International Journal of Molecular Sciences.2021; 22(10): 5246.     CrossRef
  • Histopathological study of endoscopic biopsies of large intestine
    Manjiri N Karandikar, Purva Kulkarni, Smita Mulay, R C Nimbergi, N S Mani
    Indian Journal of Pathology and Oncology.2021; 8(3): 340.     CrossRef
  • Is histological remission of ulcerative colitis achievable?
    Oleg V. Knyazev, Anna V. Kagramanova, Sergei G. Khomeriki, Asfold I. Parfenov
    Terapevticheskii arkhiv.2021; 93(8): 975.     CrossRef
  • A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
    Hadis Najafimehr, Hamid Asadzadeh Aghdaei, Mohamad Amin Pourhoseingholi, Hamid Mohaghegh Shalmani, Amir Vahedian-Azimi, Matthew Kroh, Mohammad Reza Zali, Amirhossein Sahebkar, Muhammad Naeem
    Gastroenterology Research and Practice.2021; 2021: 1.     CrossRef
  • Safety and effectiveness of adalimumab in the treatment of ulcerative colitis: results from a large-scale, prospective, multicenter, observational study
    Haruhiko Ogata, Takashi Hagiwara, Takeshi Kawaberi, Mariko Kobayashi, Toshifumi Hibi
    Intestinal Research.2021; 19(4): 419.     CrossRef
  • Histological remission of ulcerative colitis with combined anti-cytokine and cell therapy
    Oleg V. Knyazev, Sergey G. Khomeriki, Аnna V. Kagramanova, Albina A. Lishchinskaya, Olga A. Smirnova, Karina K. Noskova, Asfold I. Parfenov
    Terapevticheskii arkhiv.2021; 93(12): 1435.     CrossRef
  • Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia
    Andrew D Beggs, Jonathan James, Germaine Caldwell, Toby Prout, Mark P Dilworth, Phillipe Taniere, Tariq Iqbal, Dion G Morton, Glenn Matthews
    Inflammatory Bowel Diseases.2018; 24(7): 1503.     CrossRef
  • Can histologic remission be a better prognostic factor and therapeutic target beyond endoscopic mucosal healing in patients with ulcerative colitis?
    Hyo Jun Ahn, Sang-Bum Kang
    Intestinal Research.2018; 16(1): 1.     CrossRef
  • The Rising Incidence of Younger Patients With Colorectal Cancer: Questions About Screening, Biology, and Treatment
    Louise C. Connell, José Mauricio Mota, Maria Ignez Braghiroli, Paulo M. Hoff
    Current Treatment Options in Oncology.2017;[Epub]     CrossRef
  • Screening strategy for colorectal cancer according to risk
    Dong Soo Han
    Journal of the Korean Medical Association.2017; 60(11): 893.     CrossRef
  • 5,742 View
  • 58 Download
  • 14 Web of Science
  • 14 Crossref
Close layer
Intest Res : Intestinal Research
© Korean Association for the Study of Intestinal Diseases.
Close layer
TOP