Intestinal Research

Original Articles

IBD

Comparative effectiveness of ustekinumab versus infliximab in the management of perianal fistulizing Crohn's disease: a retrospective study in China: Mengqi Chen, Zihan Chen, Jianming Lin, Linxin Liu, Tong Tu, Xiaoling Li, Baili Chen, Yao He, Minhu Chen, Zhirong Zeng, Xiaojun Zhuang; Intest Res 2026;24(1):52-63. Published online June 11, 2025; DOI: https://doi.org/10.5217/ir.2024.00168

Abstract PDF PubReader ePub: Background/Aims
Ustekinumab (UST) and infliximab (IFX) are both effective in the treatment of perianal fistulizing Crohn’s disease (CD), but limited research has focused on comparing the efficacy of UST versus IFX in this field. This study aimed to compare the effectiveness of UST or IFX in treating perianal fistula of CD patients naive to biological agents in a real-world setting.
Methods
A retrospective cohort study included patients with perianal fistulizing CD treated with UST or IFX was conducted to evaluate the rates of luminal and perianal fistula response and remission at 6 months after treatment.
Results
Ninety-seven patients (49 UST and 48 IFX) were enrolled. Compared to IFX, UST exhibited significantly higher rates of treatment success (89.8% vs. 50.0%, P< 0.001) and intestinal clinical response (85.7% vs. 68.8%, P= 0.048), but no significant differences in fistula remission, fistula response, fistula closure, intestinal clinical remission, endoscopic remission and endoscopic response was observed. Furthermore, multivariate analyses demonstrated complexity of fistula was conversely associated with fistula remission between the UST and IFX groups. Finally, the rates of disease relapse and operation in the IFX group were higher as compared to the UST group during follow-up.
Conclusions
UST may serve as a promising alternative to IFX for the treatment of perianal fistulizing CD.

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Inflammatory bowel diseases

Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease: Yue Zhao, Baili Chen, Yao He, Shenghong Zhang, Yun Qiu, Rui Feng, Hongsheng Yang, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao; Intest Res 2020;18(2):200-209. Published online March 31, 2020; DOI: https://doi.org/10.5217/ir.2019.00103

Abstract PDF PubReader ePub

Background/Aims
Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD.
Methods
This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay.
Results
The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, P<0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, P=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (P<0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, P=0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, P<0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, P=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients.
Conclusions
Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve.

Citations

Citations to this article as recorded by

Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease
Uma Mahadevan, Cynthia H. Seow, Edward L. Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto-Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard G
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Inflammation and Ovarian Function in Reproductive‐Aged Women
Anneliese Long, Anne Z. Steiner, Amanda L. Thompson, Hannah R. Jahnke, Benjamin S. Harris, Anne Marie Jukic
American Journal of Human Biology.2025;[Epub] CrossRef
Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease
Maria Martell, Clare F. Quarnstrom, Alexander Khoruts, Vaiva Vezys, Christopher Staley, Eugenia Shmidt
Gastro Hep Advances.2025; 4(7): 100670. CrossRef
Mendelian randomization analysis reveals causal associations between autoimmune diseases and female infertility risk
Jinyuan Wang, Haojun Long, Mingxuan Su, Yichang Cao, Runtang Zhou, Xiang Li, Jiangming Li, Yuxia Tang, Jiayi Tang, Simin Wang, Linyue Tang, Ruxin Chen, Danqi Deng, Li Tang
Reproductive Toxicology.2025; 137: 108984. CrossRef
The Evolving Role of Anti-Müllerian Hormone Measurements in Clinical Practice
Xiaochun Susan Zhang, Jaime H Noguez
The Journal of Applied Laboratory Medicine.2025; 10(6): 1638. CrossRef
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease
Uma Mahadevan, Cynthia H Seow, Edward L Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto-Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard Gea
Inflammatory Bowel Diseases.2025; 31(10): 2615. CrossRef
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease
Uma Mahadevan, Cynthia H. Seow, Edward L. Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto‐Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard G
Alimentary Pharmacology & Therapeutics.2025; 62(11-12): 1125. CrossRef
Correlation between serum anti-Müllerian hormone levels and radiological markers assessed using ultrasonography and magnetic resonance imaging in patients with unilateral endometrioma: a retrospective study in Korea
Hyun Joo Lee, Eun Hee Yu, Jong Kil Joo, Yong Jin Na
Kosin Medical Journal.2025; 40(3): 199. CrossRef
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease
Uma Mahadevan, Cynthia H Seow, Edward L Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto-Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard Gea
Journal of Crohn’s and Colitis.2025;[Epub] CrossRef
Effect of Chinese Herbal Medicine on Pregnancy Outcomes in IVF Patients with Low Ovarian Reserve: A Predictive Model
Meng-Hsing Wu, Shu-Chiu Wang, Pei-Fang Su, Liang-Miin Tsai, Po-Ming Chen, Chia-Jung Li, Hsing-Ju Wu, Chiung-Hung Chang
Medicina.2025; 61(9): 1571. CrossRef
Global consensus statement on the management of pregnancy in inflammatory bowel disease
Uma Mahadevan, Cynthia H Seow, Edward L Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto-Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard Gea
Gut.2025; : gutjnl-2025-336402. CrossRef
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease
Uma Mahadevan, Cynthia H. Seow, Edward L. Barnes, María Chaparro, Emma Flanagan, Sonia Friedman, Mette Julsgaard, Sunanda Kane, Siew Ng, Joana Torres, Gillian Watermeyer, Jesus Yamamoto-Furusho, Christopher Robinson, Susan Fisher, Phil Anderson, Richard G
Clinical Gastroenterology and Hepatology.2025; 23(11): S1. CrossRef
Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
Matteo Bramuzzo, Fabiola Giudici, Serena Arrigo, Paolo Lionetti, Giovanna Zuin, Claudio Romano, Francesco Graziano, Simona Faraci, Patrizia Alvisi, Sara Signa, Luca Scarallo, Stefano Martelossi, Grazia Di Leo
Inflammatory Bowel Diseases.2024; 30(1): 20. CrossRef
Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn’s disease patients: a case-control study
Ana Gutiérrez, Roser Muñoz-Pérez, Pedro Zapater, Cristina Mira, Andrés Rodríguez, Laura Sempere-Robles, María Eugenia Torregrosa, Rocio Alfayate, Violeta Moreno-Torres, Lorena Bernal, Olivia Belén-Galipienso, Jose Ignacio Cameo, Paula Sirera, Belen Herrer
Frontiers in Medicine.2024;[Epub] CrossRef
Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis
Arthur Foulon, Nicolas Richard, Camille Guichard, Clara Yzet, Coraline Breuval, Jean Gondry, Rosalie Cabry‐Goubet, Audrey Michaud, Mathurin Fumery
Acta Obstetricia et Gynecologica Scandinavica.2024; 103(9): 1714. CrossRef
Serum anti-mullerian hormone, sex hormone, and nutrient levels in reproductive age women with celiac disease
Ailifeire Tuerxuntayi, Tian Shi, Beiyao Gao, Yan Feng, Ting Li, Wenjia Hui, Shenglong Xue, Feng Gao
Journal of Assisted Reproduction and Genetics.2024; 41(8): 2129. CrossRef
A Gender Perspective on Coloproctological Diseases: A Narrative Review on Female Disorders
Paola De Nardi, Greta Giacomel, Simone Orlandi, Giulia Poli, Mauro Pozzo, Marcella Rinaldi, Antonella Veglia, Renato Pietroletti
Journal of Clinical Medicine.2024; 13(20): 6136. CrossRef
Management strategies for inflammatory bowel disease before and during pregnancy
Xu-Jie Dai, Zhen Guo
World Chinese Journal of Digestology.2024; 32(11): 803. CrossRef
Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis
Lin Guo, Yi Liu, Jiansheng Li, Quan Liu, Bing Liu, Xuewen Shi
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Inflammatory bowel disease in pregnancy and breastfeeding
Max N. Brondfield, Uma Mahadevan
Nature Reviews Gastroenterology & Hepatology.2023; 20(8): 504. CrossRef
Case report: A pregnant woman with Crohn disease who used ustekinumab to the 3rd trimester developed severe infection
Peng Guo, Wulan Cao
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Monitoring of Inflammatory Bowel Disease in Pregnancy: A Review of the Different Modalities
Reem Al-jabri, Panu Wetwittayakhlang, Peter L. Lakatos
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Elena Santos Pérez, Marta Calvo Moya
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Camilla Ronchetti, Federico Cirillo, Noemi Di Segni, Martina Cristodoro, Andrea Busnelli, Paolo Emanuele Levi-Setti
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Ovarian reserve and IVF outcomes in patients with inflammatory bowel disease: A systematic review and meta-analysis
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THE ROLE OF IMMUNOGLOBULIN A IN THE INFLAMMATORY PROCESS INVOLVING NEUTROPHILS
O.O. Prudnikov, I.M. Prudnikov, V.M. Tsyvkin, A.M. Smirnov, R.I. Yanchiy
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30 Crossref

Surgical management of inflammatory bowel disease in China: a systematic review of two decades: Qiao Yu, Ren Mao, Lei Lian, Siew chien Ng, Shenghong Zhang, Zhihui Chen, Yanyan Zhang, Yun Qiu, Baili Chen, Yao He, Zhirong Zeng, Shomron Ben-Horin, Xinming Song, Minhu Chen; Intest Res 2016;14(4):322-332. Published online October 17, 2016; DOI: https://doi.org/10.5217/ir.2016.14.4.322

Abstract PDF Supplementary Material PubReader

<b>Background/Aims</b><br/>

The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China.

Methods

We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures.

Results

A total of 74 studies comprising 2,007 subjects with Crohn's disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P=0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P=0.026 and P <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P=0.045 for CD; P=0.020 for UC) and postoperative in-hospital mortality (P=0.0002 for CD; P=0.0160 for UC) both significantly improved after the year 2010.

Conclusions

The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China.

Citations

Citations to this article as recorded by

Remdesivir alleviates inflammation and tissue damage in experimental colitis via AnxA5 Signaling
Hailong Li, Ying Yang, Jinhe Li, Yayue Hu, Ruiqi Mao, Xiaoman Ye, Xi Wu, Zherui Li, Liqing Han, Xiaoting Gu, Hailong Cao, Honggang Zhou, Cheng Yang
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Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice
Mengchao Zhao, Yaru Lei, Mengyuan Wang, Yixin Chen, Shaozhang Hou, Xinyuan Dai, Di Gao, Yudan Liu, Bruno Mazet, Lei Sha
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Epidemiological research, burden, and clinical advances of inflammatory bowel disease in China
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Guanglin Cui, Junling Li, Hanzhe Liu, Jann-Birger Laugsand, Zhanju Liu
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8,670 View
76 Download
14 Web of Science
14 Crossref

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