Citations

Citations to this article as recorded by  

• Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: a multicenter study with pre- and post-biologics comparison
  Wei-Chen Lin, Chun-Chi Lin, Wen-Hung Hsu, Feng-Fan Chiang, Chen-Wang Chang, Tzu-Chi Hsu, Deng-Chyang Wu, Horng-Yuan Wang, Jau-Min Wong, Shu-Chen Wei
  Intestinal Research.2025;[Epub]     CrossRef
• Endoscopic Techniques for Colorectal Neoplasia Surveillance in Inflammatory Bowel Disease: A Systematic Review and Network Meta‐Analysis
  Chih‐Wen Huang, Hsu‐Heng Yen, Yang‐Yuan Chen
  United European Gastroenterology Journal.2025;[Epub]     CrossRef
• Rescue Therapies for Steroid-refractory Acute Severe Ulcerative Colitis: A Systematic Review and Network Meta-analysis
  Chih-Wen Huang, Hsu-Heng Yen, Yang-Yuan Chen
  Journal of Crohn's and Colitis.2024; 18(12): 2063.     CrossRef
• High prevalence of vitamin D deficiency in Taiwanese patients with inflammatory bowel disease
  Chen-Ta Yang, Hsu-Heng Yen, Pei-Yuan Su, Yang-Yuan Chen, Siou-Ping Huang
  Scientific Reports.2024;[Epub]     CrossRef

Citations

Citations to this article as recorded by  

• Hepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Disease
  Hye Kyung Hyun, Hye Won Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
  Gut and Liver.2024; 18(2): 294.     CrossRef
• Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients
  Ga Hee Kim, Minjun Kim, Kyuwon Kim, Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
  Yonsei Medical Journal.2024; 65(5): 276.     CrossRef
• Incidence and adverse clinical events of primary sclerosing cholangitis with ulcerative colitis
  In Sub Han, Dong Hoon Baek, Seung Min Hong, Bong Eun Lee, Moon Won Lee, Gwang Ha Kim, Geun Am Song
  International Journal of Colorectal Disease.2023;[Epub]     CrossRef
• Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
  You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
  Experimental & Molecular Medicine.2023; 55(7): 1380.     CrossRef
• Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease
  You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
  Intestinal Research.2023; 21(4): 420.     CrossRef
• Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease
  Kwang Woo Kim, Hyoun Woo Kang
  Intestinal Research.2023; 21(4): 413.     CrossRef
• Is primary sclerosing cholangitis with inflammatory bowel disease different between patients in the East and West?
  Yong Eun Park
  Intestinal Research.2022; 20(2): 157.     CrossRef

A role of gut microbiota in colorectal cancer (CRC) growth was first suggested in germ-free rats almost 50 years ago, and the existence of disease-associated bacteria (termed pathobionts) had becoming increasingly evident from experimental data of fecal transplantation, and microbial gavage or monoassociation. Altered bacterial compositions in fecal and mucosal specimens were observed in CRC patients compared to healthy subjects. Microbial fluctuations were found at various cancer stages; an increase of bacterial diversity was noted in the adenoma specimens, while a reduction of bacterial richness was documented in CRC samples. The bacterial species enriched in the human cancerous tissues included Escherichia coli, Fusobacterium nucleatum, and enterotoxigenic Bacteroides fragilis. The causal relationship of gut bacteria in tumorigenesis was established by introducing particular bacterial strains in in situ mouse CRC models. Detailed experimental protocols of bacterial gavage and the advantages and caveats of different experimental models are summarized in this review. The microbial genotoxins, enterotoxins, and virulence factors implicated in the mechanisms of bacteria-driven tumorigenesis are described. In conclusion, intestinal microbiota is involved in colon tumorigenesis. Bacteria-targeting intervention would be the next challenge for CRC.

Citations

Citations to this article as recorded by  

• Interaction of human gut microbiota and local immune system in progression of colorectal adenoma (MIMICA-1): a protocol for a prospective, observational cohort study
  Jurate Valciukiene, Egle Lastauskiene, Aida Laurinaviciene, Matas Jakubauskas, Marius Kryzauskas, Ruta Barbora Valkiuniene, Renaldas Augulis, Ausra Garnelyte, Justinas Kavoliunas, Ugne Silinskaite, Tomas Poskus
  Frontiers in Oncology.2025;[Epub]     CrossRef
• Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway
  Koki Hiura, Masaki Watanabe, Naoki Hirose, Kenta Nakano, Tadashi Okamura, Hayato Sasaki, Nobuya Sasaki
  International Journal of Molecular Sciences.2024; 25(5): 3061.     CrossRef
• Association of gut microbiome with immune microenvironment in surgically treated colorectal cancer patients
  Nayoung Han, Hee Jin Chang, Hyun Yang Yeo, Byung Chang Kim, Bun Kim, Sung Chan Park, Jeongseon Kim, Ji Won Park, Jae Hwan Oh
  Pathology.2024; 56(4): 528.     CrossRef
• A Potential Role of Xenometabolites as Nutraceutical: A Concurrent Review
  Sunanda Biswas, Ali Imran, Fakhar Islam, Muhammad Umair Arshad, Iqra Aslam, Mohd Asif Shah, Umber Shehzadi, Ifrah Usman, zza Faiz UL Rasool, Safura Aslam
  Current Research in Nutrition and Food Science Journal.2024; 12(1): 20.     CrossRef
• Could environmental exposure and climate change Be a key factor in the rising incidence of early onset colorectal cancer?
  Adhari AlZaabi, Hussein A. Younus, Hassan A. Al-Reasi, Rashid Al-Hajri
  Heliyon.2024; 10(16): e35935.     CrossRef
• Gut Microbial Dysbiosis Induced Exacerbations Influence the Progression of Colorectal Cancer
  Sharvari Sawant, Prabhu Meganathan, Hemamalini Vedagiri
  Biology Bulletin Reviews.2024; 14(6): 724.     CrossRef
• Gastrointestinal pathophysiology in long COVID: Exploring roles of microbiota dysbiosis and serotonin dysregulation in post-infectious bowel symptoms
  Linda Chia-Hui Yu
  Life Sciences.2024; 358: 123153.     CrossRef
• Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer
  Mutebi John Kenneth, Hsin-Chi Tsai, Chuan-Yin Fang, Bashir Hussain, Yi-Chou Chiu, Bing-Mu Hsu
  Journal of Advanced Research.2023; 52: 45.     CrossRef
• Tissue vs. Fecal-Derived Bacterial Dysbiosis in Precancerous Colorectal Lesions: A Systematic Review
  Jurate Valciukiene, Kestutis Strupas, Tomas Poskus
  Cancers.2023; 15(5): 1602.     CrossRef
• Human gene and microbial analyses in rectal cancer complete responses to radiotherapy
  Arielle Kae Sulit, Kasmira Wilson, John Pearson, Olin K Silander, Shienny Sampurno, Michael Michael, Robert Ramsay, Alexander Heriot, Frank Frizelle, Rachel Violet Purcell
  BJS Open.2023;[Epub]     CrossRef
• Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis
  Ling Wang, Qing-Qing Zhang, Yu-Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni
  Anti-Cancer Agents in Medicinal Chemistry.2023; 23(9): 1067.     CrossRef
• Gut microbiota and carcinogenesis: actual aspects
  Aleksandr F. Poveshchenko, Valeria N. Cherkas, Aleksey V. Kabakov, Oleg V. Kazakov
  Journal of microbiology, epidemiology and immunobiology.2023; 100(3): 247.     CrossRef
• Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms
  Sang Hoon Kim, Dong Hwan Park, Yun Jeong Lim
  The Korean Journal of Gastroenterology.2023; 82(2): 73.     CrossRef
• Risk Factors for Colorectal Polyps
  嫣琦 王
  Advances in Clinical Medicine.2023; 13(09): 14803.     CrossRef
• Microbiome in Cancer Development and Treatment
  Sona Ciernikova, Aneta Sevcikova, Beata Mladosievicova, Michal Mego
  Microorganisms.2023; 12(1): 24.     CrossRef
• Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses
  Linda Chia-Hui Yu, Shu-Chen Wei, Yi-Hsuan Li, Po-Yu Lin, Xin-Yu Chang, Jui-Ping Weng, Yin-Wen Shue, Liang-Chuan Lai, Jin-Town Wang, Yung-Ming Jeng, Yen-Hsuan Ni
  Cellular and Molecular Gastroenterology and Hepatology.2022; 13(1): 57.     CrossRef
• Epidemiology of Helicobacter pylori
  Amnon Sonnenberg
  Alimentary Pharmacology & Therapeutics.2022;[Epub]     CrossRef
• The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment
  Sang Hoon Kim, Yun Jeong Lim
  Intestinal Research.2022; 20(1): 31.     CrossRef
• Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora
  Hourieh Sadrekarimi, Zhanna R. Gardanova, Morteza Bakhshesh, Farnoosh Ebrahimzadeh, Amirhossein Fakhre Yaseri, Lakshmi Thangavelu, Zahra Hasanpoor, Firoozeh Abolhasani Zadeh, Mohammad Saeed Kahrizi
  Journal of Translational Medicine.2022;[Epub]     CrossRef
• The Potential Value of Gastric Histopathology for Predicting Colorectal Adenomatous Polyps Among the Chinese Population: A Retrospective Cross-Sectional Study
  Weiwei Li, Lin Zhang, Yuanming Jing, Yanfei Yang, Yulong Wang
  Frontiers in Oncology.2022;[Epub]     CrossRef
• The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review
  Ida J. Malesza, Joanna Bartkowiak-Wieczorek, Jakub Winkler-Galicki, Aleksandra Nowicka, Dominika Dzięciołowska, Marta Błaszczyk, Paulina Gajniak, Karolina Słowińska, Leszek Niepolski, Jarosław Walkowiak, Edyta Mądry
  Nutrients.2022; 14(17): 3478.     CrossRef
• Intratumoral microbiome and gastrointestinal cancers
  Shengnan Li, Qian Li, Wei Lu
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients
  Ciyan Chen, Min Niu, Junxi Pan, Na Du, Shumin Liu, Huanqin Li, Qiuyue He, Jian Mao, Yong Duan, Yan Du
  Gut Pathogens.2021;[Epub]     CrossRef
• Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation
  Kristopher D. Parker, Akhilendra K. Maurya, Hend Ibrahim, Sangeeta Rao, Petronella R. Hove, Dileep Kumar, Rama Kant, Bupinder Raina, Rajesh Agarwal, Kristine A. Kuhn, Komal Raina, Elizabeth P. Ryan
  Biomedicines.2021; 9(2): 144.     CrossRef
• Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis
  Antonio Biondi, Francesco Basile, Marco Vacante
  World Journal of Gastrointestinal Oncology.2021; 13(6): 495.     CrossRef
• Microbiome and gastrointestinal malignancies
  Ibrahim M Sayed, Haidi Karam-Allah Ramadan, Mohamed A El-Mokhtar, Lobna Abdel-Wahid
  Current Opinion in Physiology.2021; 22: 100451.     CrossRef
• Effect of gut microbiome on minor complications after a colonoscopy
  Jae Hyun Kim, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
  Intestinal Research.2021; 19(3): 341.     CrossRef
• Bacterial Extracellular Vesicles in Gastrointestinal Tract Cancer: An Unexplored Territory
  Sajeen Bahadur Amatya, Sonja Salmi, Veera Kainulainen, Peeter Karihtala, Justus Reunanen
  Cancers.2021; 13(21): 5450.     CrossRef
• Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
  Shakhzada Ibragimova, Revathy Ramachandran, Fahad R. Ali, Leonard Lipovich, Samuel B. Ho
  Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
• High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients
  Nasibeh Khodaverdi, Habib Zeighami, Ahmad Jalilvand, Fakhri Haghi, Negar Hesami
  BMC Cancer.2021;[Epub]     CrossRef
• Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future
  Murdani Abdullah, Ninik Sukartini, Saskia Aziza Nursyirwan, Rabbinu Rangga Pribadi, Hasan Maulahela, Amanda Pitarini Utari, Virly Nanda Muzellina, Agustinus Wiraatmadja, Kaka Renaldi
  Digestion.2021; 102(6): 823.     CrossRef
• The Role of the Gut Microbiome in Colorectal Cancer: Where Are We? Where Are We Going?
  Karina Wieczorska, Małgorzata Stolarek, Rafał Stec
  Clinical Colorectal Cancer.2020; 19(1): 5.     CrossRef
• Fecal microbiota transplantation in disease therapy
  Hanna Antushevich
  Clinica Chimica Acta.2020; 503: 90.     CrossRef
• Associations between gastric histopathology and the occurrence of colonic polyps
  A. Sonnenberg, K. O. Turner, R. M. Genta
  Colorectal Disease.2020; 22(7): 814.     CrossRef
• Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice
  Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu
  Journal of Immunology Research.2020; 2020: 1.     CrossRef
• Intestinal Macrophages at the Crossroad between Diet, Inflammation, and Cancer
  Greta Caprara, Paola Allavena, Marco Erreni
  International Journal of Molecular Sciences.2020; 21(14): 4825.     CrossRef
• Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential
  Ester Saus, Susana Iraola-Guzmán, Jesse R. Willis, Anna Brunet-Vega, Toni Gabaldón
  Molecular Aspects of Medicine.2019; 69: 93.     CrossRef
• Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer
  Thomas J Borody, Guy D Eslick, Robert L Clancy
  Current Opinion in Pharmacology.2019; 49: 43.     CrossRef
• The association between fecal enterotoxigenic B. fragilis with colorectal cancer
  Fakhri Haghi, Elshan Goli, Bahman Mirzaei, Habib Zeighami
  BMC Cancer.2019;[Epub]     CrossRef
• Who is who in oral cancer?
  Wei-long Zhang, Sha-sha Wang, Hao-fan Wang, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang
  Experimental Cell Research.2019; 384(2): 111634.     CrossRef
• Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
  Vratislav Horak, Anna Palanova, Jana Cizkova, Veronika Miltrova, Petr Vodicka, Helena Kupcova Skalnikova
  Genes.2019; 10(11): 915.     CrossRef
• Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?
  Niki Katsiki, Dimitri P. Mikhailidis, Christos Mantzoros
  Metabolism.2018; 87: A10.     CrossRef
• Echinococcus granulosus Infection Results in an Increase in Eisenbergiella and Parabacteroides Genera in the Gut of Mice
  Jianling Bao, Huajun Zheng, Yuezhu Wang, Xueting Zheng, Li He, Wenjing Qi, Tian Wang, Baoping Guo, Gang Guo, Zhaoxia Zhang, Wenbao Zhang, Jun Li, Donald P. McManus
  Frontiers in Microbiology.2018;[Epub]     CrossRef
• Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis
  Linda Chia-Hui Yu
  Journal of Biomedical Science.2018;[Epub]     CrossRef

Crohn's disease (CD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. CD is rare in Taiwan and other Asian countries, but its prevalence and incidence have been steadily increasing. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of CD taking into account currently available evidence and the expert opinion of the committee. Thorough clinical, endoscopic, and histological assessments are required for accurate diagnosis of CD. Computed tomography and magnetic resonance imaging are complementary to endoscopic evaluation for disease staging and detecting complications. The goals of CD management are to induce and maintain remission, reduce the risk of complications, and improve quality of life. Corticosteroids are the mainstay for inducing re-mission. Immunomodulating and biologic therapies should be used to maintain remission. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to treatment and receive regular surveillance for cancer. These consensus statements are based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of patients with CD in Taiwan.

Citations

Citations to this article as recorded by  

• Factors affecting perception and acceptance of colonoscopy in patients with inflammatory bowel disease
  Chang-Hung Liao, Peng-Jen Chen, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu Huang
  Preventive Medicine Reports.2025; 49: 102951.     CrossRef
• Management of Crohn’s disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023
  Jia-Feng Wu, Hsu-Heng Yen, Horng-Yuan Wang, Ting-An Chang, Chung-Hsin Chang, Chen-Wang Chang, Te-Hsin Chao, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tzu-Chi Hsu, Tien-Yu Huang, Tsung-I Hung, Puo-Hsien Le, Chun-Che Lin, Chun-Chi Lin
  Intestinal Research.2024; 22(3): 250.     CrossRef
• Current State of CT Enterography in Diagnostics and Surgical Tactics in Crohn’s Disease (Literature Review)
  A. L. Aprosimov, D. A. Lezhnev, Yu. V. Kulezneva
  Radiology - Practice.2024; (6): 67.     CrossRef
• Suboptimal Outcomes and Retreatment Rate of Patients With Crohn's Disease After Forced Discontinuation of Biologics: A Nationwide Population‐Based Study
  Nai‐Yu Chen, Chiao‐Hsiung Chuang, Yu‐Ching Chang, Yea‐Huei Kao Yang, Peng‐Hsu Chen, Ching‐Lan Cheng
  Clinical Pharmacology & Therapeutics.2023; 114(4): 914.     CrossRef
• Health Maintenance and Preventative Care in Inflammatory Bowel Disease
  Simcha Weissman, Hannah K. Systrom, Ayrton Bangolo, Daniel Elias, Marcel Awasi, Tamer Zahdeh, Chukwuemeka E. Ogbu, Mishka Hoo Kim, Meenal Kalra, Kavya Khota, Ritu B. Kasarapu, Erasmus Mutabi, Moinulhaq Makrani, Sanskrita Nemalikanti, Jim Thomas, Joseph P.
  Journal of Clinical Gastroenterology.2023; 57(4): 325.     CrossRef
• Negative pressure wound management in perineal wound status post abdominoperineal resection and extralevator abdominoperineal excision: a meta-analysis and trial sequential analysis
  Cheng-Wei Fan, Po-Huang Chen, Hong-Jie Jhou, Yi-Chiao Cheng
  International Journal of Colorectal Disease.2023;[Epub]     CrossRef
• Treatment of inflammatory bowel disease–Asian perspectives: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
  Eun Mi Song, Soo-Young Na, Sung Noh Hong, Siew Chien Ng, Tadakazu Hisamatsu, Byong Duk Ye
  Intestinal Research.2023; 21(3): 339.     CrossRef
• IBD barriers across the continents – East Asia
  Joyce Wing Yan Mak, Agnes Hiu Yan Ho, Siew Chien Ng
  Therapeutic Advances in Gastroenterology.2023;[Epub]     CrossRef
• Extra-Colonic Malignancy in Inflammatory Bowel Disease: a Paucity of Recommendations with Weak Evidence
  Simcha Weissman, Muhammad Aziz, Matthew R. Baniqued, Mohamed Ahmed, Sameh Elias, Joseph D. Feuerstein, James H. Tabibian
  Journal of Gastrointestinal Cancer.2022; 53(3): 669.     CrossRef
• Impact of Inflammatory Bowel Disease (IBD) and IBD Medications on Risk of Hyperlipidemia and in vitro Hepatic Lipogenic-Related Gene Expression: A Population-Based Cohort Study
  Ni Tien, Tien-Yuan Wu, Cheng-Li Lin, Chia-Jui Wu, Chung-Y Hsu, Yi-Jen Fang, Yun-Ping Lim
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Real‐world efficacy and safety of vedolizumab among patients with inflammatory bowel disease: A single tertiary medical center experience in Central Taiwan
  Yu‐Chiao Chiu, Chia‐Chang Chen, Chung‐Wang Ko, Szu‐Chia Liao, Hong‐Zen Yeh, Chung‐Hsin Chang
  Advances in Digestive Medicine.2021; 8(1): 40.     CrossRef
• Clinical features and treatment of inflammatory bowel disease in a low-incidence area
  Hsu-Heng Yen, Tsui-Chun Hsu, Mei-Wen Chen, Pei-Yuan Su, Yang-Yuan Chen
  Medicine.2021; 100(10): e25090.     CrossRef
• Quality assessment of clinical guidelines on probiotics therapy in children with IBD using the AGREE II instrument
  Haixin Cheng, Ziyin Ma, Boran Yu, Xiaohui Liu, Chao Tian, Xuli Zhong, Libo Zhao
  Journal of Clinical Pharmacy and Therapeutics.2021; 46(4): 1155.     CrossRef
• Clinicopathological and Molecular Features of Patients with Early and Late Recurrence after Curative Surgery for Colorectal Cancer
  Yuan-Tzu Lan, Shih-Ching Chang, Pei-Ching Lin, Chun-Chi Lin, Hung-Hsin Lin, Sheng-Chieh Huang, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Jen-Kou Lin
  Cancers.2021; 13(8): 1883.     CrossRef
• Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing)
  
  Journal of Digestive Diseases.2021; 22(6): 298.     CrossRef
• Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study
  Hsu-Heng Yen, Pei-Yuan Su, Siou-Ping Huang, Lisha Wu, Tsui-Chun Hsu, Ya-Huei Zeng, Yang-Yuan Chen, Wan-Long Chuang
  PLOS ONE.2021; 16(5): e0252286.     CrossRef
• Systematic evaluation of the diagnostic approach of inflammatory bowel disease guidelines
  Bing‐He Xiao, Xu‐Dong Ma, Jia‐Jun Lv, Ting Yang, Xin‐Jie Liu, Li‐Ya An, Yu‐Xing Qi, Ming‐Liang Lu, Yong‐Qing Duan, Da‐Li Sun
  International Journal of Clinical Practice.2021;[Epub]     CrossRef
• Clinical significance of granulomas in Crohn's disease: A systematic review and meta‐analysis
  Seung Wook Hong, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
  Journal of Gastroenterology and Hepatology.2020; 35(3): 364.     CrossRef
• Diagnostic efficacy of double-balloon enteroscopy in patients with suspected isolated small bowel Crohn’s disease
  Zihan Huang, Xiang Liu, Fei Yang, Guoxin Wang, Nan Ge, Sheng Wang, Jintao Guo, Siyu Sun
  BMC Gastroenterology.2020;[Epub]     CrossRef
• Incidence of suboptimal response to tumor necrosis factor antagonist therapy in inflammatory bowel disease in newly industrialised countries: The EXPLORE study
  Jesus K. Yamamoto-Furusho, Othman Al Harbi, Alessandro Armuzzi, Webber Chan, Enrique Ponce de Leon, Jiaming Qian, Marina Shapina, Murat Toruner, Chia-Hung Tu, Byong Duk Ye, Morgane Guennec, Cecilia Sison, Dirk Demuth, Olga Fadeeva, Qasim M. Rana Khan
  Digestive and Liver Disease.2020; 52(8): 869.     CrossRef
• Strengthened monitoring and optimized management of Crohn’s disease patients
  Jing-Jing Wang, Yi-Hong Fan, Rong Huang
  World Chinese Journal of Digestology.2020; 28(15): 660.     CrossRef
• Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries
  Rupa Banerjee, Raja Affendi Raja Ali, Shu Chen Wei, Shashi Adsul
  Gut and Liver.2020; 14(6): 685.     CrossRef
• Innovative Animal Model of DSS-Induced Ulcerative Colitis in Pseudo Germ-Free Mice
  Sona Gancarcikova, Stanislav Lauko, Gabriela Hrckova, Zuzana Andrejcakova, Vanda Hajduckova, Marian Madar, Livia Kolesar Fecskeova, Dagmar Mudronova, Kristina Mravcova, Gabriela Strkolcova, Radomira Nemcova, Jana Kacirova, Andrea Staskova, Stefan Vilcek,
  Cells.2020; 9(12): 2571.     CrossRef
• Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates
  Hau-Jyun Su, Yu-Tse Chiu, Chuan-Tai Chiu, Yen-Chun Lin, Chen-Yu Wang, Jui-Ying Hsieh, Shu-Chen Wei
  Journal of the Formosan Medical Association.2019; 118(7): 1083.     CrossRef
• Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study
  Hsu-Heng Yen, Meng-Tzu Weng, Chien-Chih Tung, Yu-Ting Wang, Yuan Ting Chang, Chin-Hao Chang, Ming-Jium Shieh, Jau-Min Wong, Shu-Chen Wei
  Intestinal Research.2019; 17(1): 54.     CrossRef
• Response to Chamberlin and Borody
  Gary R. Lichtenstein, Edward V. Loftus, Kim L. Isaacs, Miguel D. Regueiro, Bruce E. Sands
  American Journal of Gastroenterology.2019; 114(1): 171.     CrossRef
• Immunogenicity of biologic therapies: causes and consequences
  Wolf-Henning Boehncke, Nicolo Costantino Brembilla
  Expert Review of Clinical Immunology.2018; 14(6): 513.     CrossRef
• Changing treatment paradigms for the management of inflammatory bowel disease
  Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
  The Korean Journal of Internal Medicine.2018; 33(1): 28.     CrossRef
• Changes in hepatitis B virus surface antibody titer and risk of hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients undergoing biologic therapy for rheumatic diseases: a prospective cohort study
  Ya-Chih Tien, Hsu-Heng Yen, Ching-Fang Li, Mei-Ping Liu, Yin-Tzu Hsue, Ming-Hui Hung, Ying-Ming Chiu
  Arthritis Research & Therapy.2018;[Epub]     CrossRef
• Balloon-Assisted Enteroscopy and Capsule Endoscopy in Suspected Small Bowel Crohn’s Disease
  Hsu-Heng Yen, Chen-Wang Chang, Jen-Wei Chou, Shu-Chen Wei
  Clinical Endoscopy.2017; 50(5): 417.     CrossRef

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis. The goals of UC therapy are to induce and maintain remission, reduce the risk of complications, and improve quality of life. As outlined in the recommended treatment algorithm, choice of treatment is dictated by severity, extent, and course of disease. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to immunosuppressive treatment, especially with steroids and biologic agents, and should be regularly monitored for reactivation of latent infection. These consensus statements are also based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of UC in Taiwan.

Citations

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• Factors affecting perception and acceptance of colonoscopy in patients with inflammatory bowel disease
  Chang-Hung Liao, Peng-Jen Chen, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu Huang
  Preventive Medicine Reports.2025; 49: 102951.     CrossRef
• Clinical Characteristics, Management, and Outcomes of Colitis-Associated Colorectal Cancer and the Comparison With Sporadic Colorectal Cancer in Taiwan
  Hsin-Yun Wu, Meng-Tzu Weng, Jen-Wei Chou, Hsu-Heng Yen, Chun-Chi Lin, Feng-Fan Chiang, Chen-Shuan Chung, Wei-Chen Lin, Chen-Wang Chang, Puo-Hsien Le, Chia-Jung Kuo, Ching-Pin Lin, Wen-Hung Hsu, Chiao-Hsiung Chuang, Tzung-Jiun Tsai, I-Che Feng, Shu-Chen We
  Clinical and Translational Gastroenterology.2025; 16(2): e00798.     CrossRef
• Moxifloxacin promotes two-photon microscopic imaging for discriminating different stages of DSS-induced colitis on mice
  Yingtong Chen, Xiaoyi Xu, Min Wang, Xiang Wang, Yan Wang, Yong Zhang, Jin Huang, Yuwen Tao, Wentao Fan, Lili Zhao, Li Liu, Zhining Fan
  Photodiagnosis and Photodynamic Therapy.2024; 48: 104220.     CrossRef
• High prevalence of vitamin D deficiency in Taiwanese patients with inflammatory bowel disease
  Chen-Ta Yang, Hsu-Heng Yen, Pei-Yuan Su, Yang-Yuan Chen, Siou-Ping Huang
  Scientific Reports.2024;[Epub]     CrossRef
• Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023
  Hsu-Heng Yen, Jia-Feng Wu, Horng-Yuan Wang, Ting-An Chang, Chung-Hsin Chang, Chen-Wang Chang, Te-Hsin Chao, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tzu-Chi Hsu, Tien-Yu Huang, Tsung-I Hung, Puo-Hsien Le, Chun-Che Lin, Chun-Chi Lin
  Intestinal Research.2024; 22(3): 213.     CrossRef
• Systemic Immune-Inflammation Index: Unveiling the Diagnostic Potential in Ulcerative Colitis through a Comprehensive Systematic Review and Meta-Analysis
  Anas Elgenidy, Omar Alomari, Tasbih Emad, Sara K. Kamal, Islam E. Al Ghanam, Aya Sherif, Mohammed Al-mahdi Al-kurdi, Abdallah A. Helal, Yusof Mohamed Omar, Mohamed Rafiek Ramadan
  Gastroenterology & Endoscopy.2024;[Epub]     CrossRef
• Real‐world experience of adalimumab therapy for patients with ulcerative colitis: A single tertiary medical center experience in Central Taiwan
  Hsu‐Heng Yen, Yu‐Chun Hsu, Chu‐Hsuan Kuo, Tsui‐Chun Hsu, Yang‐Yuan Chen
  Advances in Digestive Medicine.2023; 10(1): 28.     CrossRef
• Improvement of ulcerative colitis control by searching and restricting of inflammatory trigger factors in daily clinical practice
  Kun-Yu Tsai, Jeng-Fu You, Tzong-Yun Tsai, Yih Jong Chern, Yu-Jen Hsu, Shu-Huan Huang, Wen-Sy Tsai
  Intestinal Research.2023; 21(1): 100.     CrossRef
• Real-World Evidence of Effectiveness and Safety of Vedolizumab for Inflammatory Bowel Disease in Taiwan: A Prospective Nationwide Registry (VIOLET) Study
  Wei-Chen Lin, Wei-Chen Tai, Chung-Hsin Chang, Chia-Hung Tu, I-Che Feng, Ming-Jium Shieh, Chen-Shuan Chung, Hsu-Heng Yen, Jen-Wei Chou, Jau-Min Wong, Yu-Hwa Liu, Tien-Yu Huang, Chiao-Hsiung Chuang, Tzung-Jiun Tsai, Feng-Fan Chiang, Chien-Yu Lu, Wen-Hung Hs
  Inflammatory Bowel Diseases.2023; 29(11): 1730.     CrossRef
• Health Maintenance and Preventative Care in Inflammatory Bowel Disease
  Simcha Weissman, Hannah K. Systrom, Ayrton Bangolo, Daniel Elias, Marcel Awasi, Tamer Zahdeh, Chukwuemeka E. Ogbu, Mishka Hoo Kim, Meenal Kalra, Kavya Khota, Ritu B. Kasarapu, Erasmus Mutabi, Moinulhaq Makrani, Sanskrita Nemalikanti, Jim Thomas, Joseph P.
  Journal of Clinical Gastroenterology.2023; 57(4): 325.     CrossRef
• Treatment of inflammatory bowel disease–Asian perspectives: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
  Eun Mi Song, Soo-Young Na, Sung Noh Hong, Siew Chien Ng, Tadakazu Hisamatsu, Byong Duk Ye
  Intestinal Research.2023; 21(3): 339.     CrossRef
• Association between ulcerative colitis and Helicobacter pylori infection: A case-control study
  Iyad Ali, Qusay Abdo, Shayma'a M. Al-Hihi, Ansam Shawabkeh
  Heliyon.2022; 8(2): e08930.     CrossRef
• Impact of Inflammatory Bowel Disease (IBD) and IBD Medications on Risk of Hyperlipidemia and in vitro Hepatic Lipogenic-Related Gene Expression: A Population-Based Cohort Study
  Ni Tien, Tien-Yuan Wu, Cheng-Li Lin, Chia-Jui Wu, Chung-Y Hsu, Yi-Jen Fang, Yun-Ping Lim
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Discovery and Validation of Potential Serum Biomarkers with Pro-Inflammatory and DNA Damage Activities in Ulcerative Colitis: A Comprehensive Untargeted Metabolomic Study
  Mingxiao Li, Rui Zhang, Mingjie Xin, Yi Xu, Shijia Liu, Boyang Yu, Boli Zhang, Jihua Liu
  Metabolites.2022; 12(10): 997.     CrossRef
• Chemoprevention of Colitis-Associated Dysplasia or Cancer in Inflammatory Bowel Disease
  Shun-Wen Hsiao, Hsu-Heng Yen, Yang-Yuan Chen
  Gut and Liver.2022; 16(6): 840.     CrossRef
• Serum homocysteine level was elevated in ulcerative colitis and can be applied as diagnostic biomarker
  Xiaoping Zhang, Shanshan Wang, Hongmin Wang, Junxia Wu, Qihua Tan
  Pteridines.2022; 33(1): 87.     CrossRef
• Real‐world efficacy and safety of vedolizumab among patients with inflammatory bowel disease: A single tertiary medical center experience in Central Taiwan
  Yu‐Chiao Chiu, Chia‐Chang Chen, Chung‐Wang Ko, Szu‐Chia Liao, Hong‐Zen Yeh, Chung‐Hsin Chang
  Advances in Digestive Medicine.2021; 8(1): 40.     CrossRef
• Clinical features and treatment of inflammatory bowel disease in a low-incidence area
  Hsu-Heng Yen, Tsui-Chun Hsu, Mei-Wen Chen, Pei-Yuan Su, Yang-Yuan Chen
  Medicine.2021; 100(10): e25090.     CrossRef
• Comparison of outcomes of cyclosporine A and infliximab for steroid‐refractory acute severe ulcerative colitis
  Eun Mi Song, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang, Byong Duk Ye
  Journal of Gastroenterology and Hepatology.2021; 36(9): 2463.     CrossRef
• Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study
  Hsu-Heng Yen, Pei-Yuan Su, Siou-Ping Huang, Lisha Wu, Tsui-Chun Hsu, Ya-Huei Zeng, Yang-Yuan Chen, Wan-Long Chuang
  PLOS ONE.2021; 16(5): e0252286.     CrossRef
• Systematic evaluation of the diagnostic approach of inflammatory bowel disease guidelines
  Bing‐He Xiao, Xu‐Dong Ma, Jia‐Jun Lv, Ting Yang, Xin‐Jie Liu, Li‐Ya An, Yu‐Xing Qi, Ming‐Liang Lu, Yong‐Qing Duan, Da‐Li Sun
  International Journal of Clinical Practice.2021;[Epub]     CrossRef
• Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
  Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
  International Journal of Molecular Sciences.2021; 22(15): 8274.     CrossRef
• Efficacy and safety of Etiasa for treatment of mild-to-moderate ulcerative colitis: A Meta-analysis
  Fang-Mei Ling, Fei-Nan Lu, Sheng-Nan Wang, Liang-Ru Zhu
  World Chinese Journal of Digestology.2021; 29(15): 880.     CrossRef
• Association between Ulcerative Colitis and Helicobacter pylori Infection: A Case-Control Study
  Iyad Ali, Qusay Abdo, Shayma’a M. Al-Hihi, Ansam Shawabkeh
  SSRN Electronic Journal .2021;[Epub]     CrossRef
• A case with cytomegalovirus colitis and toxic megacolon initially diagnosed as Crohn's disease
  Shan-Han Chang, Hsin-Yun Sun, Chia-Tung Shun, Shu-Chen Wei
  Journal of the Formosan Medical Association.2020; 119(9): 1442.     CrossRef
• Incidence of suboptimal response to tumor necrosis factor antagonist therapy in inflammatory bowel disease in newly industrialised countries: The EXPLORE study
  Jesus K. Yamamoto-Furusho, Othman Al Harbi, Alessandro Armuzzi, Webber Chan, Enrique Ponce de Leon, Jiaming Qian, Marina Shapina, Murat Toruner, Chia-Hung Tu, Byong Duk Ye, Morgane Guennec, Cecilia Sison, Dirk Demuth, Olga Fadeeva, Qasim M. Rana Khan
  Digestive and Liver Disease.2020; 52(8): 869.     CrossRef
• Predictive values of stool-based tests for mucosal healing among Taiwanese patients with ulcerative colitis: a retrospective cohort analysis
  Hsu-Heng Yen, Mei-Wen Chen, Yu-Yao Chang, Hsuan-Yuan Huang, Tsui-Chun Hsu, Yang-Yuan Chen
  PeerJ.2020; 8: e9537.     CrossRef
• Ulcerative colitis
  Taku Kobayashi, Britta Siegmund, Catherine Le Berre, Shu Chen Wei, Marc Ferrante, Bo Shen, Charles N. Bernstein, Silvio Danese, Laurent Peyrin-Biroulet, Toshifumi Hibi
  Nature Reviews Disease Primers.2020;[Epub]     CrossRef
• Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries
  Rupa Banerjee, Raja Affendi Raja Ali, Shu Chen Wei, Shashi Adsul
  Gut and Liver.2020; 14(6): 685.     CrossRef
• To assess the effective and safety of berberine hydrochloride in ulcerative colitis
  Yong Zhang, Jin Wang, Daorui Hou, Shuguang Yan, Sijie Dang
  Medicine.2020; 99(49): e23482.     CrossRef
• Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates
  Hau-Jyun Su, Yu-Tse Chiu, Chuan-Tai Chiu, Yen-Chun Lin, Chen-Yu Wang, Jui-Ying Hsieh, Shu-Chen Wei
  Journal of the Formosan Medical Association.2019; 118(7): 1083.     CrossRef
• Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide populationbased study
  Hsu-Heng Yen, Meng-Tzu Weng, Chien-Chih Tung, Yu-Ting Wang, Yuan Ting Chang, Chin-Hao Chang, Ming-Jium Shieh, Jau-Min Wong, Shu-Chen Wei
  Intestinal Research.2019; 17(1): 54.     CrossRef
• Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study
  Soo-Kyung Park, Sang Hyun Park, Chang Soo Eun, Geom Seog Seo, Jong Pil Im, Tae Oh Kim, Dong-Il Park
  Intestinal Research.2019; 17(3): 349.     CrossRef
• Effectiveness of sigmoidoscopy for assessing ulcerative colitis disease activity and therapeutic response
  Wei-Chen Lin, Chen-Wang Chang, Ming-Jen Chen, Tzu-Chi Hsu, Horng-Yuan Wang
  Medicine.2019; 98(21): e15748.     CrossRef
• Ulcerative Colitis in Elderly People: An Emerging Issue
  Wei-Chen Lin, Ming-Jen Chen, Cheng-Hsin Chu, Tsang-En Wang, Horng-Yuan Wang, Chen-Wang Chang
  International Journal of Gerontology.2018;[Epub]     CrossRef
• Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
  Ji Young Chang, Sung-Ae Jung, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
  Intestinal Research.2018; 16(4): 599.     CrossRef
• Efficacy and Safety of Hou Gu Mi Xi on Spleen Qi Deficiency in Patients with Nonorganic Gastrointestinal Disorders: Protocol for a Multicenter, Randomized, Placebo‐Controlled Trial
  Xiaofan Chen, Heyun Nie, Wenjun Liu, Xu Zhou, Jianhua Nie, Bin Xie, Dongping Chen, Yiping Jiang, Kunhe Zhang, Ying Fu, Deping Yang, Yan Xiong, Zhangyang Zhao, Xin Sun, Weifeng Zhu, Carmen Mannucci
  Evidence-Based Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis
  Wei-Chen Lin, Chen-Wang Chang, Ming-Jen Chen, Cheng-Hsin Chu, Shou-Chuan Shih, Tzu-Chi Hsu, Horng-Yang Wang, John Green
  PLOS ONE.2017; 12(12): e0189377.     CrossRef