Intestinal Research

Case Report

IBD

Pediatric Crohn’s disease with severe morbidity manifested by gastric outlet obstruction: two cases report and review of the literature: Eun Sil Kim, Ji Hyung Park, Yon Ho Choe, Mi Jin Kim; Intest Res 2021;19(4):472-477. Published online October 29, 2020; DOI: https://doi.org/10.5217/ir.2020.00072

Crohn’s disease (CD) presenting as gastric outlet obstruction is rare but serious clinical presentation of CD causing severe morbidity. However, there have been few case reports concerning this disorder in East Asian children and adolescents. The current case report describes 2 pediatric patients with CD who had had gastric outlet obstruction as an initial symptom of CD. Two pediatric patients developed postprandial vomiting, bloating, and unintentional weight loss. The upper endoscopy result indicated that there was pyloric obstruction with mucosal edema, inflammation and ulcers. The serologic test and colonoscopy results suggested CD. These patients were treated with infliximab, and endoscopic balloon dilation without surgery and showed remarkable improvement in obstructing symptoms with maintaining clinical and biochemical remission. This case report elucidates the benefits of early intervention using infliximab and endoscopic balloon dilation to improve gastric outlet obstruction and achieve baseline recovery in patients with upper gastrointestinal B2 phenotype of CD.

Citations

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Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents
Eun Sil Kim, Mi Jin Kim
Clinical and Experimental Pediatrics.2022; 65(1): 21. CrossRef

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Original Article

Microbiota

Characterization of the fecal microbiota differs between age groups in Koreans: Sun-Young Kook, Yunjeong Kim, Ben Kang, Yon Ho Choe, Young-Ho Kim, Seokjin Kim; Intest Res 2018;16(2):246-254. Published online April 30, 2018; DOI: https://doi.org/10.5217/ir.2018.16.2.246

Abstract PDF Supplementary Material PubReader ePub

<b>Background/Aims</b><br/>

Tens of trillions of microorganisms constitute the gut microbiota of the human body. The microbiota plays a critical role in maintaining host immunity and metabolism. Analyses of the gut microbial composition in Korea are limited to a few studies consisting of small sample sizes. To investigate the gut microbial community in a large sample of healthy Koreans, we analyzed the 16S ribosomal RNA of 4 representative bacterial genera Lactobacillus, Bifidobacterium, Bacteroides, and Clostridium.

Methods

A total of 378 DNA samples extracted from 164 infants and 214 adults were analyzed using quantitative real-time polymerase chain reaction.

Results

Analysis of 16S ribosomal RNA of 4 representative bacterial genera Lactobacillus, Bifidobacterium, Bacteroides, and Clostridium showed that the gut microbiota in infants had higher relative abundances of Bifidobacterium and Lactobacillus than that in adults, which was dominated by Bacteroides and Clostridium.

Conclusions

To the best of our knowledge, this was the first study evaluating the distinct characteristics of the microbial community of Korean infants and adults. The differences between the 2 populations suggest that external factors such as age, diet, and the environment are important contributing factors to the change in gut microbial composition during development.

Citations

Citations to this article as recorded by

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Fermentation.2023; 9(8): 716. CrossRef
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Journal of Food Hygiene and Safety.2023; 38(5): 338. CrossRef
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Metabolites.2021; 11(3): 136. CrossRef
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Sarah E Haworth, Kevin S White, Steeve D Côté, Aaron B A Shafer
FEMS Microbiology Ecology.2019;[Epub] CrossRef
Isolation and characterization of five novel probiotic strains from Korean infant and children faeces
Sun-Young Kook, Eui-Chun Chung, Yaelim Lee, Dong Wan Lee, Seokjin Kim, Sudarshan Kumar
PLOS ONE.2019; 14(10): e0223913. CrossRef
Characteristics of Faecal Microbiota in Korean Patients withClostridioides difficile-associated Diarrhea
Yong Duk Jeon, Hea Won Ann, Woon Ji Lee, Jun Hyoung Kim, Hye Seong, Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon Sup Yeom, Dongeun Yong, Kyungwon Lee, Jun Yong Choi
Infection & Chemotherapy.2019; 51(4): 365. CrossRef

8,573 View
177 Download
6 Web of Science
7 Crossref

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