Background/Aims Incidences of inflammatory bowel diseases (IBDs), ulcerative colitis (UC), and Crohn’s disease (CD), have been increasing in Asia. In this study, we report the relevant clinical characteristics and determined the epidemiological trend of IBD in Taiwan from 2001 to 2015.
Methods A retrospective study was conducted to analyze data recorded from January 2001 through December 2015 in the registered database compiled by the National Health Insurance and provided by the Ministry of Health and Welfare, Taiwan.
Results A total of 3,806 patients with catastrophic IBD illness were registered from 2001 to 2015 in Taiwan (CD, 919; UC, 2,887). The crude incidence of CD increased from 0.17/100,000 in 2001 to 0.47/100,000 in 2015, whereas that of UC increased from 0.54/100,000 in 2001 to 0.95/100,000 in 2015. The prevalence of CD increased from 0.6/100,000 in 2001 to 3.9/100,000 in 2015, whereas that of UC increased from 2.1/100,000 in 2001 to 12.8/100,000 in 2015. The male-to-female ratio in the study sample was 2.19 for CD and 1.62 for UC. The median age of those registered with CD was lower than that of those registered for UC: 38.86 and 44.86 years, respectively. A significantly greater increase in CD incidence rate was identified among 20 to 39-year-old compared with other age groups.
Conclusions Using Taiwan’s nationwide insurance database, we determined that the number of patients with CD increased more rapidly during the study period than the number of patients with UC, especially among age 20 to 39-year-old, resulting in a decreased UC-to-CD ratio.
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Current status of inflammatory bowel diseases in Korea Suk-Kyun Yang Journal of the Korean Medical Association.2021; 64(9): 572. CrossRef
Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis? Jin Wook Lee, Eun Soo Kim Gut and Liver.2021; 15(5): 639. CrossRef
Association Between Ischemic Optic Neuropathy and Inflammatory Bowel Disease: A Population-Based Cohort Study in Taiwan Ting-Yi Lin, Yi-Fen Lai, Po-Huang Chen, Chi-Hsiang Chung, Ching-Long Chen, Yi-Hao Chen, Jiann-Torng Chen, Po-Chen Kuo, Wu-Chien Chien, Yun-Hsiu Hsieh Frontiers in Medicine.2021;[Epub] CrossRef
Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea Jae Yong Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Ho-Su Lee, Kyung-Wook Jo, Sang Hyoung Park BMC Gastroenterology.2021;[Epub] CrossRef
Exploring Links Between Industrialization, Urbanization, and Chinese Inflammatory Bowel Disease Guanglin Cui, Hanzhe Liu, Gang Xu, Jann-Birger Laugsand, Zhigang Pang Frontiers in Medicine.2021;[Epub] CrossRef
Endoscopic Mucosal Healing as a Treatment Target in Ulcerative Colitis: Does It Have the Same Role in Asian Patients? Suk-Kyun Yang, Sang Hyoung Park, Byong Duk Ye Gut and Liver.2021; 15(6): 942. CrossRef
Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom? Soo-Young Na, Yun-Jeong Lim Diagnostics.2021; 11(12): 2240. CrossRef
Biologic Use Patterns and Predictors for Non-persistence and Switching of Biologics in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study Yoon Suk Jung, Minkyung Han, Sohee Park, Jae Hee Cheon Digestive Diseases and Sciences.2020; 65(5): 1436. CrossRef
Crohn’s disease and ulcerative colitis are associated with different lipid profile disorders: a nationwide population‐based study Hosim Soh, Jong Pil Im, Kyungdo Han, Seona Park, Seung Wook Hong, Jeong Min Moon, Eun Ae Kang, Jaeyoung Chun, Hyun Jung Lee, Joo Sung Kim Alimentary Pharmacology & Therapeutics.2020; 51(4): 446. CrossRef
The epidemiology of inflammatory bowel disease: East meets west Wing Yan Mak, Mirabella Zhao, Siew Chien Ng, Johan Burisch Journal of Gastroenterology and Hepatology.2020; 35(3): 380. CrossRef
Comparison of Real-World Outcomes of Infliximab versus Adalimumab in Biologic-Naïve Korean Patients with Ulcerative Colitis: A Population-Based Study Minkyung Han, Yoon Suk Jung, Jae Hee Cheon, Sohee Park Yonsei Medical Journal.2020; 61(1): 48. CrossRef
A case with cytomegalovirus colitis and toxic megacolon initially diagnosed as Crohn's disease Shan-Han Chang, Hsin-Yun Sun, Chia-Tung Shun, Shu-Chen Wei Journal of the Formosan Medical Association.2020; 119(9): 1442. CrossRef
Trends in Healthcare Costs for Inflammatory Bowel Disease in South Korea Yoon Suk Jung Gut and Liver.2020; 14(1): 3. CrossRef
Cost‐effectiveness analysis of fecal microbiota transplantation for recurrent Clostridium difficile infection in patients with inflammatory bowel disease Joyce H S You, Xinchan Jiang, Wally H Lee, Paul K S Chan, Siew C Ng Journal of Gastroenterology and Hepatology.2020; 35(9): 1515. CrossRef
Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products Karma Yeshi, Roland Ruscher, Luke Hunter, Norelle L. Daly, Alex Loukas, Phurpa Wangchuk Journal of Clinical Medicine.2020; 9(5): 1273. CrossRef
Predictive values of stool-based tests for mucosal healing among Taiwanese patients with ulcerative colitis: a retrospective cohort analysis Hsu-Heng Yen, Mei-Wen Chen, Yu-Yao Chang, Hsuan-Yuan Huang, Tsui-Chun Hsu, Yang-Yuan Chen PeerJ.2020; 8: e9537. CrossRef
Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study Yi-Ju Chen, Chao-Kuei Juan, Yun-Ting Chang, Chun-Ying Wu, Hsiu J. Ho, Hsiao-Ching Tseng Scientific Reports.2020;[Epub] CrossRef
Lactobacilli and bifidobacteria derived from infant intestines may activate macrophages and lead to different IL-10 secretion Huijing Liang, Zihao Luo, Zhonghua Miao, Xi Shen, Ming Li, Xuguang Zhang, Jiehua Chen, Xiaolei Ze, Qiwei Chen, Fang He Bioscience, Biotechnology, and Biochemistry.2020; 84(12): 2558. CrossRef
Temporal trend of disease recognition, treatment paradigm, and clinical outcomes of Crohn disease in Thailand from 2000 through 2017 Julajak Limsrivilai, Satimai Aniwan, Asawin Sudcharoen, Natapat Chaisidhivej, Piyaphan Prueksapanich, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya, Supot Pongprasobchai, Sathaporn Manassatit Medicine.2020; 99(38): e22216. CrossRef
Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells Sing-Chung Li, Wei-Fang Hsu, Jung-Su Chang, Chun-Kuang Shih Nutrients.2019; 11(5): 969. CrossRef
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study Hsin-Hua Chen, Wen-Cheng Chao, Yi-Hsing Chen, Tsu-Yi Hsieh, Kuo-Lung Lai, Yi-Ming Chen, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng, Ching-Heng Lin Arthritis Research & Therapy.2019;[Epub] CrossRef
Comparison of outcomes of continuation/discontinuation of 5-aminosalicylic acid after initiation of anti-tumor necrosis factor-alpha therapy in patients with inflammatory bowel disease Youn I Choi, Tae Jun Kim, Dong Kyun Park, Jun-won Chung, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim International Journal of Colorectal Disease.2019; 34(10): 1713. CrossRef
Microscopic features of small bowel mucosa of patients with Crohn’s disease Yun Cui, Shi-yuan Lu, Jie Xu, Yan-shen Peng, Qi Miao, Xiao-qing Wang, Xiao-yu Chen, Zhi-hua Ran BMC Gastroenterology.2019;[Epub] CrossRef