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- Inflammatory bowel diseases
- Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease
- Yue Zhao, Baili Chen, Yao He, Shenghong Zhang, Yun Qiu, Rui Feng, Hongsheng Yang, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao
- Intest Res 2020;18(2):200-209. Published online March 31, 2020
- DOI: https://doi.org/10.5217/ir.2019.00103
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Abstract
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ePub - Background/Aims
Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate potential risk factors associated with low ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) in women of reproductive age with CD.
Methods
This was a case-control study. Cases included 87 patients with established CD, and healthy controls were matched by age, height and weight in a 1:1 ratio. Serum AMH levels were measured by enzyme-linked immunosorbent assay.
Results
The average serum AMH level was significantly lower in CD patients than in control group (2.47±2.08 ng/mL vs. 3.87±1.96 ng/mL, respectively, P<0.001). Serum AMH levels were comparable between CD patients and control group under 25 years of age (4.41±1.52 ng/mL vs. 3.49±2.10 ng/mL, P=0.06), however, serum AMH levels were significantly lower in CD patients over 25 years of age compared to control group (P<0.05). Multivariable analysis showed that an age greater than 25 (odds ratio [OR], 10.03; 95% confidence interval [CI], 1.90–52.93, P=0.007), active disease state (OR, 27.99; 95% CI, 6.13–127.95, P<0.001) and thalidomide use (OR, 15.66; 95% CI, 2.22–110.65, P=0.006) were independent risk factors associated with low ovarian reserve (serum AMH levels <2 ng/mL) in CD patients.
Conclusions
Ovarian reserve is impaired in young women of reproductive age with CD. Age over 25 and an active disease state were both independently associated with low ovarian reserve. Thalidomide use could result in impaired ovarian reserve. -
Citations
Citations to this article as recorded by
- Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
Matteo Bramuzzo, Fabiola Giudici, Serena Arrigo, Paolo Lionetti, Giovanna Zuin, Claudio Romano, Francesco Graziano, Simona Faraci, Patrizia Alvisi, Sara Signa, Luca Scarallo, Stefano Martelossi, Grazia Di Leo
Inflammatory Bowel Diseases.2024; 30(1): 20. CrossRef - Inhibin B and antiMüllerian hormone as surrogate markers of fertility in male and female Crohn’s disease patients: a case-control study
Ana Gutiérrez, Roser Muñoz-Pérez, Pedro Zapater, Cristina Mira, Andrés Rodríguez, Laura Sempere-Robles, María Eugenia Torregrosa, Rocio Alfayate, Violeta Moreno-Torres, Lorena Bernal, Olivia Belén-Galipienso, Jose Ignacio Cameo, Paula Sirera, Belen Herrer
Frontiers in Medicine.2024;[Epub] CrossRef - Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis
Arthur Foulon, Nicolas Richard, Camille Guichard, Clara Yzet, Coraline Breuval, Jean Gondry, Rosalie Cabry‐Goubet, Audrey Michaud, Mathurin Fumery
Acta Obstetricia et Gynecologica Scandinavica.2024; 103(9): 1714. CrossRef - Serum anti-mullerian hormone, sex hormone, and nutrient levels in reproductive age women with celiac disease
Ailifeire Tuerxuntayi, Tian Shi, Beiyao Gao, Yan Feng, Ting Li, Wenjia Hui, Shenglong Xue, Feng Gao
Journal of Assisted Reproduction and Genetics.2024; 41(8): 2129. CrossRef - Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis
Lin Guo, Yi Liu, Jiansheng Li, Quan Liu, Bing Liu, Xuewen Shi
Medicine.2023; 102(11): e33113. CrossRef - Inflammatory bowel disease in pregnancy and breastfeeding
Max N. Brondfield, Uma Mahadevan
Nature Reviews Gastroenterology & Hepatology.2023; 20(8): 504. CrossRef - Case report: A pregnant woman with Crohn disease who used ustekinumab to the 3rd trimester developed severe infection
Peng Guo, Wulan Cao
Medicine.2023; 102(48): e36253. CrossRef - Monitoring of Inflammatory Bowel Disease in Pregnancy: A Review of the Different Modalities
Reem Al-jabri, Panu Wetwittayakhlang, Peter L. Lakatos
Journal of Clinical Medicine.2023; 12(23): 7343. CrossRef - General review of pregnancy in inflammatory bowel disease
Elena Santos Pérez, Marta Calvo Moya
Revista Española de Enfermedades Digestivas.2022;[Epub] CrossRef - Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review
Camilla Ronchetti, Federico Cirillo, Noemi Di Segni, Martina Cristodoro, Andrea Busnelli, Paolo Emanuele Levi-Setti
Nutrients.2022; 14(8): 1591. CrossRef - Ovarian reserve and IVF outcomes in patients with inflammatory bowel disease: A systematic review and meta-analysis
Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
eClinicalMedicine.2022; 50: 101517. CrossRef - Inflammatory Bowel Disease and Pregnancy
Eugenia Shmidt, Marla C. Dubinsky
American Journal of Gastroenterology.2022; 117(10S): 60. CrossRef - Reproductive Health in IBD Patients
Sanket Patel, Haleh Vaziri
Current Treatment Options in Gastroenterology.2021; 19(2): 237. CrossRef - Ovarian Reserve Assessed by the Anti-Mullerian Hormone and Reproductive Health Parameters in Women With Crohn´s Disease, a Case-Control Study
T. Koller, J. Kollerová, T. Hlavatý, B. Kadlečková, J. Payer
Physiological Research.2021; : S69. CrossRef - THE ROLE OF IMMUNOGLOBULIN A IN THE INFLAMMATORY PROCESS INVOLVING NEUTROPHILS
O.O. Prudnikov, I.M. Prudnikov, V.M. Tsyvkin, A.M. Smirnov, R.I. Yanchiy
Fiziolohichnyĭ zhurnal.2021; 67(5): 44. CrossRef - Update on Pregnancy in Patients with IBD
Rachel W. Winter, Sonia Friedman
Current Treatment Options in Gastroenterology.2020; 18(3): 423. CrossRef
- Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
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- 130 Download
- 14 Web of Science
- 16 Crossref
- Surgical management of inflammatory bowel disease in China: a systematic review of two decades
- Qiao Yu, Ren Mao, Lei Lian, Siew chien Ng, Shenghong Zhang, Zhihui Chen, Yanyan Zhang, Yun Qiu, Baili Chen, Yao He, Zhirong Zeng, Shomron Ben-Horin, Xinming Song, Minhu Chen
- Intest Res 2016;14(4):322-332. Published online October 17, 2016
- DOI: https://doi.org/10.5217/ir.2016.14.4.322
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Abstract
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Supplementary MaterialPubReader <b>Background/Aims</b><br/> The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China.
Methods We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures.
Results A total of 74 studies comprising 2,007 subjects with Crohn's disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (
P =0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P =0.026 andP <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P =0.045 for CD;P =0.020 for UC) and postoperative in-hospital mortality (P =0.0002 for CD;P =0.0160 for UC) both significantly improved after the year 2010.Conclusions The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China.
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Citations
Citations to this article as recorded by- Epidemiological research, burden, and clinical advances of inflammatory bowel disease in China
Hong Yang, Jiaming Qian
Chinese Medical Journal.2024; 137(9): 1009. CrossRef - Laparoscopic surgery contributes to a decrease in short-term complications in surgical ulcerative colitis patients during 2008–2017: a multicenter retrospective study in China
Zerong Cai, Xiaosheng He, Jianfeng Gong, Peng Du, Wenjian Meng, Wei Zhou, Jinbo Jiang, Bin Wu, Weitang Yuan, Qi Xue, Lianwen Yuan, Jinhai Wang, Jiandong Tai, Jie Liang, Weiming Zhu, Ping Lan, Xiaojian Wu
Intestinal Research.2023; 21(2): 235. CrossRef - Differences in inflammatory bowel diseases between East and West: a Chinese perspective
Guanglin Cui, Junling Li, Hanzhe Liu, Jann-Birger Laugsand, Zhanju Liu
Journal of Public Health.2021; 29(1): 19. CrossRef - Diagnostic and Predictive Value of Immune-Related Genes in Crohn’s Disease
Bing Yu, Yi-xin Yin, Yan-ping Tang, Kang-lai Wei, Zhi-gang Pan, Ke-Zhi Li, Xian-wen Guo, Bang-li Hu
Frontiers in Immunology.2021;[Epub] CrossRef - Role of a multidisciplinary team (MDT) in the diagnosis, treatment, and outcomes of inflammatory bowel disease: a single Chinese center's experience
Qiang Wu, Xuehong Wang, Feng Wu, Dehong Peng, Guotao Wu, Lichao Yang, Lianwen Yuan
BioScience Trends.2021; 15(3): 171. CrossRef - MANAGEMENT OF ILEOCECAL CROHN’S DISEASE DURING SURGICAL TREATMENT FOR ACUTE APPENDICITIS: A SYSTEMATIC REVIEW
Abel Botelho QUARESMA, Eron Fabio MIRANDA, Paulo Gustavo KOTZE
Arquivos de Gastroenterologia.2021; 58(4): 560. CrossRef - Risk factors and long-term outcome of disease extent progression in Asian patients with ulcerative colitis: a retrospective cohort study
Yun Qiu, Baili Chen, Yufei Li, Shanshan Xiong, Shenghong Zhang, Yao He, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen, Ren Mao
BMC Gastroenterology.2019;[Epub] CrossRef - Initial medical and surgical management of inflammatory bowel disease in the biologic era: A comparison between the United States and China
Sanskriti Varma, Jun Hu, Ambar Mehta, Yiran Song, Angela Park, Min Zhi, Susan Hutfless
JGH Open.2019; 3(3): 234. CrossRef - Can molecular stratification improve the treatment of inflammatory bowel disease?
Claire Wang, Hannah M. Baer, Daniel R. Gaya, Robert J.B. Nibbs, Simon Milling
Pharmacological Research.2019; 148: 104442. CrossRef - Intrarectally administered polaprezinc attenuates the development of dextran sodium sulfate‑induced ulcerative colitis in mice
Zhaoyang Liu, Wenbo Xie, Mingru Li, Jing Liu, Xiao Liang, Tao Li
Experimental and Therapeutic Medicine.2019;[Epub] CrossRef - Changing treatment paradigms for the management of inflammatory bowel disease
Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
The Korean Journal of Internal Medicine.2018; 33(1): 28. CrossRef - Is Adsorptive Granulocyte and Monocyte Apheresis Effective as an Alternative Treatment Option in Patients with Ulcerative Colitis?
Seong Ran Jeon
Gut and Liver.2017; 11(2): 171. CrossRef
- Epidemiological research, burden, and clinical advances of inflammatory bowel disease in China
- 5,956 View
- 75 Download
- 12 Web of Science
- 12 Crossref
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