Intestinal Research

Original Articles

Miscellaneous

Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis: Kensuke Sakurai, Takehiko Katsurada, Mutsumi Nishida, Satomi Omotehara, Shinya Fukushima, Shinsuke Otagiri, Kazunori Nagashima, Reizo Onishi, Ryo Takagi, Yoshito Komatsu, Naoya Sakamoto; Intest Res 2023;21(1):126-136. Published online July 22, 2022; DOI: https://doi.org/10.5217/ir.2021.00166

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Background/Aims
The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis.
Methods
We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CTCAE) grade version 5.
Results
Fourteen patients with IMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r=0.687, p=0.009) and CTCAE grade (r=0.628, p=0.035). Bowel wall thickness and UCEIS (r=0.628, p=0.020), as well as color Doppler signal grade and CTCAE grade (r=0.724, p=0.008), were significantly correlated.
Conclusions
US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of IMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.

Citations

Citations to this article as recorded by

Symptomatic and Sonographic Improvement of Immune Checkpoint Inhibitor Enterocolitis With Risankizumab
Rena Mei, Emily Pepe, David Y Oh, Katy K Tsai, Rishika Chugh, Michael G Kattah
Inflammatory Bowel Diseases.2025; 31(4): 1182. CrossRef
Response
Malek Shatila, Yinghong Wang
Gastrointestinal Endoscopy.2024; 100(2): 349. CrossRef
Ultrasound's echo in the endoscopic realm: navigating checkpoint colitis
Steven Nicolaides, Zaid Ardalan, Alex Boussioutas
Gastrointestinal Endoscopy.2024; 100(2): 349. CrossRef
Systematic review of immune checkpoint inhibitor-related gastrointestinal, hepatobiliary, and pancreatic adverse events
Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bre
Journal for ImmunoTherapy of Cancer.2024; 12(11): e009742. CrossRef
Endoscopic findings of immune checkpoint inhibitor-related gastrointestinal adverse events
Min Kyu Kim, Sung Wook Hwang
Clinical Endoscopy.2024; 57(6): 725. CrossRef
Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review
Sung Wook Hwang, Min Kyu Kim, Mi-Na Kweon
Intestinal Research.2023; 21(4): 433. CrossRef

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Association of Gallbladder Polyp with the Risk of Colorectal Adenoma: Jung Won Jeun, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jun Uk Lim; Intest Res 2014;12(1):48-52. Published online January 28, 2014; DOI: https://doi.org/10.5217/ir.2014.12.1.48

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<b>Background/Aims</b><br/>

Gallbladder polyps and colorectal adenomas share many common risk factors; however, their association has never been studied. The aim of this study was to investigate this association in asymptomatic healthy subjects.

Methods

Consecutive asymptomatic subjects who underwent both screening colonoscopy and abdominal ultrasonography at Kyung Hee University Hospital in Gang Dong between July 2010 and April 2011 were prospectively enrolled. The prevalence of colorectal adenoma was compared between subjects with or without gallbladder polyps. Furthermore, a logistic regression analysis was performed to determine the independent risk factors for colorectal adenoma in these subjects.

Results

Of the 581 participants, 55 presented with gallbladder polyps and 526 did not have gallbladder polyps. Participants with gallbladder polyps showed a trend toward a higher prevalence of colorectal adenoma than those without gallbladder polyps (52.7% vs. 39.2%, P=0.051). Although the result was not statistically significant, gallbladder polyps were found to be a possible risk factor for colorectal adenoma (odds ratio=1.796, 95% confidence interval=0.986-3.269, P=0.055), even after adjusting for potential confounding factors. There was no difference observed in colorectal adenoma characteristics between the two groups.

Conclusions

Our results suggest a possible association between gallbladder polyps and colorectal adenomas. Future studies with larger cohorts are warranted to further investigate this matter.

Citations

Citations to this article as recorded by

Association between gallbladder disease and colorectal neoplasia: a meta-analysis
Wenbin Geng, Kai Ma, Yizhou Jiang, Shiyu Peng, Xiaoyong Wang
Scientific Reports.2025;[Epub] CrossRef
Metabolic dysfunction-associated steatotic liver disease and gallbladder polyp development: an observational study
Masahiro Sogabe, Toshiya Okahisa, Miwako Kagawa, Takanori Kashihara, Shota Fujmoto, Tomoyuki Kawaguchi, Reiko Yokoyama, Kaizo Kagemoto, Hironori Tanaka, Yoshifumi Kida, Tetsu Tomonari, Yasushi Sato, Masahiko Nakasono, Tetsuji Takayama
Scientific Reports.2024;[Epub] CrossRef
Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps?
Nihan Turhan, Didem Ertorul, Cengiz Duran, Meryem Gözde Kılıç, Taha Yusuf Kuzan, Servan Yaşar, Dilek Yılmaz, Elbrus Zarbaliyev
Cureus.2024;[Epub] CrossRef
Risk Factors for Colorectal Polyps
嫣琦王
Advances in Clinical Medicine.2023; 13(09): 14803. CrossRef
Research Progress of Factors Related to CRP in Middle-Aged and Elderly People
瑞武邢
Advances in Clinical Medicine.2022; 12(11): 10466. CrossRef
Association of gallbladder diseases with risk of gastrointestinal polyps
Wenbin Geng, Xiangrong Qin, Peng Yang, Junmei Wang, Jing Yu, Xiaoyong Wang
BMC Gastroenterology.2022;[Epub] CrossRef
Gallbladder Polyps Are Associated with Proximal Colon Polyps
Kuan-Chieh Lee, Wen-Juei Jeng, Chen-Ming Hsu, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef
Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study
Alharbi Mohammad
Journal of Surgery and Surgical Research.2019; 5(1): 047. CrossRef
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef
Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps
Taeyoung Lee, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(1): 317. CrossRef
Can gallbladder polyps predict colorectal adenoma or even neoplasia? A systematic review
Konstantinos Stergios, Christos Damaskos, Maximos Frountzas, Nikolaos Nikiteas, Olutunde Lalude
International Journal of Surgery.2016; 33: 23. CrossRef
The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases
Sung Noh Hong, Tae Yoon Lee, Sung-Cheol Yun
Journal of Korean Medical Science.2015; 30(9): 1288. CrossRef
Recent Updates on the Diagnosis and Management of Gallbladder Polyps
Eaum Seok Lee
Korean Journal of Pancreas and Biliary Tract.2014; 19(2): 64. CrossRef

5,915 View
47 Download
8 Web of Science
13 Crossref

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