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Original Articles
- Inhibitory Effect of Metformin Therapy on the Incidence of Colorectal Advanced Adenomas in Patients With Diabetes
- Yo Han Kim, Ran Noh, Sun Young Cho, Seong Jun Park, Soung Min Jeon, Hyun Deok Shin, Suk Bae Kim, Jeong Eun Shin
- Intest Res 2015;13(2):145-152. Published online April 27, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.2.145
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Abstract
PDF
PubReader <b>Background/Aims</b><br/> Metformin use has been associated with decreased colorectal cancer risk and mortality among diabetic patients. Recent research suggests that metformin use may decrease the incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. This study aimed to assess the clinical effect of metformin use on the development of colorectal adenomas in diabetic patients without previous colorectal cancer.
Methods Among 604 consecutive diabetic patients who underwent colonoscopic surveillance after initial colonoscopy between January 2002 and June 2012, 240 patients without previous colorectal cancer were enrolled in this study and were divided in two groups: 151 patients receiving metformin and 89 patients not receiving metformin. Patient demographics and clinical characteristics as well as the colorectal adenoma incidence rate were retrospectively analyzed.
Results The incidence rate of total colorectal adenomas was not different according to metformin use (
P =0.349). However, the advanced adenoma incidence rate was significantly lower in the metformin group compared with the non-metformin group (relative risk [RR], 0.09;P =0.011). Metformin use was independently associated with a decreased incidence of advanced colorectal adenomas after adjustment for clinically relevant factors (RR, 0.072;P =0.016). In addition, the cumulative development rate of advanced adenomas during follow-up was significantly lower in the metformin group compared with the non-metformin group (P =0.007).Conclusions Metformin use in diabetic patients without previous colorectal cancer is associated with a lower risk of advanced colorectal adenomas.
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Citations
Citations to this article as recorded by
- Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis
Mengdan Shen, Shan Lu, Zihao Xu, Feifei Zhou, Li-Ting Sheng, Qiang Yu
Frontiers in Pharmacology.2025;[Epub] CrossRef - Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas
Anna Krigel, Snow Trinh T. Nguyen, Nawar Talukder, Ching-Ho Huang, Carlos Buitrago, Gabriel Karkenny, Benjamin Lebwohl, Julian A. Abrams, James L. Araujo
Digestive Diseases and Sciences.2022; 67(10): 4886. CrossRef - The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients
Jana Halamkova, Tomas Kazda, Lucie Pehalova, Roman Gonec, Sarka Kozakova, Lucia Bohovicova, Ondrej Slaby, Regina Demlova, Marek Svoboda, Igor Kiss
Frontiers in Oncology.2021;[Epub] CrossRef - Suppressive effects of metformin on colorectal adenoma incidence and malignant progression
Min Deng, Siqin Lei, Dongdong Huang, Hui Wang, Shuli Xia, Enping Xu, Yihua Wu, Honghe Zhang
Pathology - Research and Practice.2020; 216(2): 152775. CrossRef - Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression
Cheng-Ann Winston Ng, Amy Aimei Jiang, Emma Min Shuen Toh, Cheng Han Ng, Zhi Hao Ong, Siyu Peng, Hui Yu Tham, Raghav Sundar, Choon Seng Chong, Chin Meng Khoo
International Journal of Colorectal Disease.2020; 35(8): 1501. CrossRef - Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments
Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier
Clinical Science.2020; 134(16): 2117. CrossRef - Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
The Korean Journal of Internal Medicine.2019; 34(5): 998. CrossRef - Diabetes Mellitus: a Clinical Condition Associated with Metabolic Syndrome and Colorectal Cancer Risk
Vesna Brzacki, Aleksandar Nagorni, Manolis Kallistratos, Athanasios Manolis, Dragan Lovic
Current Pharmacology Reports.2019; 5(4): 205. CrossRef - Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs
Junichi Kato, Yohei Shirakami, Masahito Shimizu
Gastrointestinal Disorders.2019; 1(2): 273. CrossRef - Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes
Joshua Demb, Armaan Yaseyyedi, Lin Liu, Ranier Bustamante, Ashley Earles, Pradipta Ghosh, J. Silvio Gutkind, Andrew J. Gawron, Tonya R. Kaltenbach, Maria Elena Martinez, Samir Gupta
Clinical and Translational Gastroenterology.2019; 10(11): e00092. CrossRef - Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects
Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin-Rong Zhou, Ishwar Parhar
Journal of Experimental & Clinical Cancer Research.2019;[Epub] CrossRef - Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer
Hee Seung Lee, Sung Bae Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
Gastrointestinal Endoscopy.2018; 87(3): 688. CrossRef - Metformin use and the risk of colorectal adenoma: A systematic review and meta‐analysis
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
Journal of Gastroenterology and Hepatology.2017; 32(5): 957. CrossRef - The effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma
Min Seok Han, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
International Journal of Colorectal Disease.2017; 32(8): 1223. CrossRef - Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth
Eun-Kyung Kim, Jae Hee Cho, EuiJoo Kim, Yoon Jae Kim, Aamir Ahmad
PLOS ONE.2017; 12(7): e0181183. CrossRef - Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia
Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(5): 918. CrossRef - Synergistic Benefit of Statin and Metformin in Gastrointestinal Malignancies
George K. Nimako, Zachary A. P. Wintrob, Dmitriy A. Sulik, Jennifer L. Donato, Alice C. Ceacareanu
Journal of Pharmacy Practice.2017; 30(2): 185. CrossRef - Risk Factors for False Fecal Immunochemical Test Results in Colorectal Cancer Screening
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef - Parameters of Glucose and Lipid Metabolism Affect the Occurrence of Colorectal Adenomas Detected by Surveillance Colonoscopies
Nam Hee Kim, Jung Yul Suh, Jung Ho Park, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(2): 347. CrossRef - Are Hemorrhoids Associated with False-Positive Fecal Immunochemical Test Results?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Yonsei Medical Journal.2017; 58(1): 150. CrossRef - Association Between Low Relative Muscle Mass and the Risk of Colorectal Neoplasms
Yoon Suk Jung, Nam Hee Kim, Seungho Ryu, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Clinical Gastroenterology.2017; 51(10): e83. CrossRef - Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Oncotarget.2017; 8(5): 8843. CrossRef - Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis
Feifei Liu, Lijing Yan, Zhan Wang, Yuanan Lu, Yuanyuan Chu, Xiangyu Li, Yisi Liu, Dongsheng Rui, Shaofa Nie, Hao Xiang
Oncotarget.2017; 8(9): 16017. CrossRef - Kaffee senkt Rückfallrate bei Patienten mit Kolonkarzinom im Stadium III
Michael Fink
Info Onkologie.2016; 19(4): 24. CrossRef - Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Vibha Rani, Gagan Deep, Rakesh K. Singh, Komaraiah Palle, Umesh C.S. Yadav
Life Sciences.2016; 148: 183. CrossRef - Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
Digestive Diseases and Sciences.2016; 61(9): 2694. CrossRef
- Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis
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- 40 Download
- 27 Web of Science
- 26 Crossref
- Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
- Yoon Kyung Song, Young Sook Park, Choon Sik Seon, Hye Jin Lim, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Ji Hyun Lee, Seung Chan Kim
- Intest Res 2015;13(1):74-79. Published online January 29, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.1.74
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Abstract
PDFPubReader
<b>Background/Aims</b><br/> Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.
Methods Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.
Results 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697;
P =0.002), and multiple adenoma (OR, 1.929;P =0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P =0.003) in alcoholic liver diseases group (17 patients), 3.711 (P =0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P =0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.Conclusions This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.
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Citations
Citations to this article as recorded by- Association between drinking patterns and advanced colorectal adenomas
Sheng-Yan Lu, Si-Yuan Ding, Li-Yuan Cui, Jia-Yu Li, Xiao-Lei Qin, Xu Liu
World Chinese Journal of Digestology.2025; 33(7): 562. CrossRef - Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia
Kwang Woo Kim, Hyoun Woo Kang, Hosun Yoo, Yukyung Jun, Hyun Jung Lee, Jong Pil Im, Ji Won Kim, Joo Sung Kim, Seong-Joon Koh, Yong Jin Jung, Atsushi Hosui
PLOS ONE.2022; 17(12): e0279242. CrossRef - Value of combined detection of IFOBT, tumor markers, and inflammatory markers in predicting occurrence of advanced colorectal adenoma
Xu Wang, Jing-Yu Zhang, Zhong-Qing Zheng, Tao Wang, Mei-Yu Piao, Heng Liu, Jing Liu, Wen-Tian Liu
World Chinese Journal of Digestology.2021; 29(7): 347. CrossRef - Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly
Shiyu Zhang, Junyong Zhang, Yonghwan Kim, Wangyang Zhang
Healthcare.2021; 9(10): 1400. CrossRef - Associations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study
Doratha A Byrd, Suzanne E Judd, W Dana Flanders, Terryl J Hartman, Veronika Fedirko, Tanya Agurs-Collins, Roberd M Bostick
JNCI Cancer Spectrum.2020;[Epub] CrossRef - Adenoma Characteristics and the Influence of Alcohol and Cigarette Consumption on the Development of Advanced Colorectal Adenomas
Maja Čebohin, Senka Samardžić, Ksenija Marjanović, Martina Tot Vesić, Kristina Kralik, Andreja Bartulić, Dijana Hnatešen
International Journal of Environmental Research and Public Health.2020; 17(22): 8296. CrossRef - Associations of Novel Dietary and Lifestyle Inflammation Scores with Incident, Sporadic Colorectal Adenoma
Doratha A. Byrd, Suzanne Judd, W. Dana Flanders, Terryl J. Hartman, Veronika Fedirko, Roberd M. Bostick
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(11): 2300. CrossRef - Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
The Korean Journal of Internal Medicine.2019; 34(5): 998. CrossRef - Interplay of Liver Disease and Gut Microbiota in the Development of Colorectal Neoplasia
Michael W. Gleeson
Current Treatment Options in Gastroenterology.2019; 17(3): 378. CrossRef - Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef - The fecal immunochemical test has high accuracy for detecting advanced colorectal neoplasia before age 50
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Digestive and Liver Disease.2017; 49(5): 557. CrossRef - Risk Factors for False Fecal Immunochemical Test Results in Colorectal Cancer Screening
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Journal of Clinical Gastroenterology.2017; 51(2): 151. CrossRef - Sarcopenia is associated with an increased risk of advanced colorectal neoplasia
Youn Su Park, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Jae Kyung Lee, Joo Sung Kim, Seong-Joon Koh
International Journal of Colorectal Disease.2017; 32(4): 557. CrossRef - Alcoholic Liver Disease Is Associated with an Increased Risk of Gastric Cancer
Tae Hoon Ha, Byeong Gwan Kim, Donghyong Jeong, Sohee Oh, Won Kim, Yong Jin Jung, Dong Won Ahn, Ji Bong Jeong, Ji Won Kim, Kook Lae Lee, Seong-Joon Koh
Digestive Diseases and Sciences.2017; 62(1): 273. CrossRef - Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
Yi-Chao Hou, Qiang Hu, Jiao Huang, Jing-Yuan Fang, Hua Xiong
Oncotarget.2017; 8(5): 8843. CrossRef - Statin use and the risk of colorectal adenoma: A meta‐analysis
Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
Journal of Gastroenterology and Hepatology.2016; 31(11): 1823. CrossRef - Weight Change and Obesity Are Associated with a Risk of Adenoma Recurrence
Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi
Digestive Diseases and Sciences.2016; 61(9): 2694. CrossRef - Metabolic syndrome is a risk factor for adenoma occurrence at surveillance colonoscopy
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Medicine.2016; 95(32): e4454. CrossRef - Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
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World Journal of Gastroenterology.2016; 22(10): 2981. CrossRef - Does Low Threshold Value Use Improve Proximal Neoplasia Detection by Fecal Immunochemical Test?
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Digestive Diseases and Sciences.2016; 61(9): 2685. CrossRef - Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
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Digestion.2016; 93(3): 202. CrossRef - Risk Factors for Colorectal Cancer in Thailand
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Asian Pacific Journal of Cancer Prevention.2015; 16(14): 6105. CrossRef
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- 8,736 View
- 43 Download
- 22 Web of Science
- 23 Crossref
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