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Performing colonoscopy before steroid induction is associated with shorter steroid use in patients with ulcerative colitis
Taku Kobayashi, Eri Udagawa, Lisa Hirose, Toshifumi Hibi
Intest Res 2023;21(2):205-215.   Published online December 15, 2022
DOI: https://doi.org/10.5217/ir.2021.00164
AbstractAbstract PDFPubReaderePub
Background/Aims
Risks of long-term steroid use in patients with ulcerative colitis (UC) outweigh the benefits, thus dosing should be tapered once a response is achieved. Colonoscopy is a key technique for assessing disease severity and optimizing treatment involving steroids. This retrospective longitudinal cohort study of patients with UC explored factors associated with the duration of systemic steroid use.
Methods
The Japan Medical Data Center database, an employer-based insurance claims database, was used to select individuals initiating prednisolone, with a prescription issued between January 1, 2010, and January 31, 2018. The study included adults with a confirmed diagnosis of UC, who had received ≥1 year of continuous treatment with 5-aminosalicylic acid, biologics, or thiopurine. Factors associated with prednisolone duration were assessed using a multivariate regression model.
Results
Median duration of prednisolone treatment was 98 days, and colonoscopy was performed ≤1 month before or at the first prescription of prednisolone (index date) in 32.8% of patients (607/1,853). Shorter durations of prednisolone treatment were associated with colonoscopy ≤1 month before or at the index date and higher prednisolone dose at index date, with incidence rate ratios (IRRs) of 0.776 (95% confidence interval [CI], 0.682–0.884; P<0.001) and 0.998 (95% CI, 0.996–1.000; P=0.018), respectively. Charlson Comorbidity Index scores of 1 and ≥2 predicted longer prednisolone treatment (IRR, 1.332; 95% CI, 1.174–1.511; P<0.001 and IRR, 1.599; 95% CI, 1.357–1.885; P<0.001, respectively).
Conclusions
Performing colonoscopy before or at the time of initiating steroid was associated with a shorter duration of steroid use in patients with UC.

Citations

Citations to this article as recorded by  
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  • 5,877 View
  • 367 Download
  • 2 Web of Science
  • 2 Crossref
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Reviews
Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease
Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chia-Tung Shun, Yuk-Ming Tsang, Cheng-Yi Wang, Horng-Yuan Wang, Meng-Tzu Weng, Deng-Chyang Wu, Wen-Chieh Wu, Hsu-Heng Yen, Jau-Min Wong
Intest Res 2017;15(3):285-310.   Published online June 12, 2017
DOI: https://doi.org/10.5217/ir.2017.15.3.285
AbstractAbstract PDFPubReaderePub

Crohn's disease (CD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. CD is rare in Taiwan and other Asian countries, but its prevalence and incidence have been steadily increasing. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of CD taking into account currently available evidence and the expert opinion of the committee. Thorough clinical, endoscopic, and histological assessments are required for accurate diagnosis of CD. Computed tomography and magnetic resonance imaging are complementary to endoscopic evaluation for disease staging and detecting complications. The goals of CD management are to induce and maintain remission, reduce the risk of complications, and improve quality of life. Corticosteroids are the mainstay for inducing re-mission. Immunomodulating and biologic therapies should be used to maintain remission. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to treatment and receive regular surveillance for cancer. These consensus statements are based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of patients with CD in Taiwan.

Citations

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Close layer
Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease
Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chia-Tung Shun, Yuk-Ming Tsang, Cheng-Yi Wang, Horng-Yuan Wang, Meng-Tzu Weng, Deng-Chyang Wu, Wen-Chieh Wu, Hsu-Heng Yen, Jau-Min Wong
Intest Res 2017;15(3):266-284.   Published online June 12, 2017
DOI: https://doi.org/10.5217/ir.2017.15.3.266
AbstractAbstract PDFPubReaderePub

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis. The goals of UC therapy are to induce and maintain remission, reduce the risk of complications, and improve quality of life. As outlined in the recommended treatment algorithm, choice of treatment is dictated by severity, extent, and course of disease. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to immunosuppressive treatment, especially with steroids and biologic agents, and should be regularly monitored for reactivation of latent infection. These consensus statements are also based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of UC in Taiwan.

Citations

Citations to this article as recorded by  
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    Chang-Hung Liao, Peng-Jen Chen, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu Huang
    Preventive Medicine Reports.2025; 49: 102951.     CrossRef
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Second Korean guidelines for the management of ulcerative colitis
Chang Hwan Choi, Won Moon, You Sun Kim, Eun Soo Kim, Bo-In Lee, Yunho Jung, Yong Sik Yoon, Heeyoung Lee, Dong Il Park, Dong Soo Han
Intest Res 2017;15(1):7-37.   Published online January 31, 2017
DOI: https://doi.org/10.5217/ir.2017.15.1.7
AbstractAbstract PDFPubReaderePub

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during exacerbation of the disease. The incidence and prevalence of UC in Korea are still lower than those of Western countries, but have been rapidly increasing during the past decades. Various medical and surgical therapies, including biologics, are currently used for the management of UC. However, many challenging issues exist, which sometimes lead to differences in practice between clinicians. Therefore, the IBD study group of the Korean Association for the Study of Intestinal Diseases established the first Korean guidelines for the management of UC in 2012. This is an update of the first guidelines. It was generally made by the adaptation of several foreign guidelines as was the first edition, and encompasses treatment of active colitis, maintenance of remission, and indication of surgery for UC. The specific recommendations are presented with the quality of evidence and classification of recommendations.

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Intestinal Stricture in Crohn's Disease
Chen-Wang Chang, Jau-Min Wong, Chien-Chih Tung, I-Lun Shih, Horng-Yuan Wang, Shu-Chen Wei
Intest Res 2015;13(1):19-26.   Published online January 29, 2015
DOI: https://doi.org/10.5217/ir.2015.13.1.19
AbstractAbstract PDFPubReader

Crohn's disease (CD) is a disease with chronic inflammation of unknown etiology involving any part of the gastrointestinal tract. The incidence and prevalence of CD are increasing recently in Asia. Half of the CD patients will have intestinal complications, such as strictures or fistulas, within 20 years after diagnosis. Twenty-five percentage of CD patients have had at least one small bowel stricture and 10% have had at least one colonic stricture and lead to significant complications. Most of these patients will require at least one surgery during their lifetime. Early diagnosis and evaluation with adequate managements for the patients can prevent disability and mortality of these patient. Here, we reviewed the current incidence of CD with stricture, the etiology of stricture, and how to diagnose and manage the stricture.

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  • MicroRNA Sequencing of Serum Exosomes Reveals miR205-5p as an Anti-Fibrogenic Factor Against Intestinal Fibrosis in Crohn’s Disease
    Ying Xie, Mieke van Daelen, Rebecca Park, Isabella Almaraz, Lindsey Fontenot, Florian Rieder, Wendy Ho, Berkeley Limketkai, David Q. Shih, Minjie Wei, Yiling Li, Hon Wai Koon
    International Journal of Molecular Sciences.2025; 26(8): 3778.     CrossRef
  • The Role of Diet in Crohn’s Disease: From Etiology to Evidence-Based Management
    Fares Jamal, Mayar H Alatout, Muhammad Ali Khan, Syed B Pasha, Talha A Malik
    Cureus.2025;[Epub]     CrossRef
  • Evaluating luminal and post-operative Crohn’s disease activity on magnetic resonance enterography: A review of radiological disease activity scores
    Richard W Lo, Gauraang Bhatnagar, Numan Kutaiba, Ashish R Srinivasan
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Duodenal Crohn’s disease: Case report and systematic review
    Muniratu Amadu, Jonathan Soldera
    World Journal of Methodology.2024;[Epub]     CrossRef
  • Infective Endocarditis After Endoscopic Stricture Dilation in Crohn's Disease
    André Gonçalves, Sandra Barbeiro, Carina Leal, Antonieta Santos, Helena Vasconcelos
    ACG Case Reports Journal.2024; 11(6): e01377.     CrossRef
  • Association between nutritional status assessed by body mass index and Crohn's disease phenotype: A Nation-wide analysis
    Judwin Ndzo, Sudheer K. Vuyyuru, Thomas Trimble, Kaung Yan, Grazziela Figueredo, Gordon W. Moran
    Clinical Nutrition ESPEN.2024; 64: 290.     CrossRef
  • Perioperative optimization of Crohn's disease
    Chun‐Chi Lin, Hung‐Hsin Lin, Hui‐Chuen Chen, Nai‐Chia Chen, I‐Lun Shih, Ji‐Shiang Hung, Te‐Cheng Yueh, Feng‐Fan Chiang, Ping‐Wei Lin, Yuan‐Yao Tsai, Shu‐Chen Wei
    Annals of Gastroenterological Surgery.2023; 7(1): 10.     CrossRef
  • Treatment escalation and de-escalation decisions in Crohn’s disease: Delphi consensus recommendations from Japan, 2021
    Hiroshi Nakase, Motohiro Esaki, Fumihito Hirai, Taku Kobayashi, Katsuyoshi Matsuoka, Minoru Matsuura, Makoto Naganuma, Masayuki Saruta, Kiichiro Tsuchiya, Motoi Uchino, Kenji Watanabe, Tadakazu Hisamatsu, Akira Andoh, Shigeki Bamba, Motohiro Esaki, Mikihi
    Journal of Gastroenterology.2023; 58(4): 313.     CrossRef
  • Ileocecal valve that cannot be intubated in Crohn’s disease: is this a sign of poor prognosis?
    Muhammed Bahaddin Durak, Cem Simsek, Bayram İnan, Ilhami Yuksel
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats
    Aline Garnevi-Fávero , Karina Nascimento-da Silva , Willian Rodrigues-Ribeiro , Caroline Marcantonio-Ferreira , Patrícia Sartorelli, Leonardo Cardili, Rita De Cássia-Sinigaglia , Joice Naiara Bertaglia-Pereira, Marcelo Aparecido-da Silva , Wagner Vilega
    Biomédica.2023; 43(2): 282.     CrossRef
  • Small Bowel Imaging from Stepchild of Roentgenology to MR Enterography: Part I: Guidance in Performing and Observing Normal and Abnormal Imaging Findings
    Antonio Pierro, Laura Maria Minordi, Luigi Larosa, Giulia Guerri, Alessandro Grimaldi, Fabio Quinto, Fabio Rotondi, Annalisa Marcellino, Teresa Bevere, Raffaella Basilico, Roberto Iezzi, Savino Cilla
    Life.2023; 13(8): 1691.     CrossRef
  • Small Bowel Imaging from Stepchild of Roentgenology to MR Enterography, Part II: The Reliable Disclosure of Crohn’s Disease and Non-Inflammatory Small Bowel Disorder Plot through MRI Findings
    Antonio Pierro, Laura Maria Minordi, Luigi Larosa, Carla Cipri, Giulia Guerri, Fabio Quinto, Fabio Rotondi, Annalisa Marcellino, Raffaella Basilico, Roberto Iezzi, Savino Cilla
    Life.2023; 13(9): 1836.     CrossRef
  • Use of oral diet and nutrition support in management of stricturing and fistulizing Crohn's disease
    Kush Fansiwala, Neha D. Shah, Kelly A. McNulty, Mary R. Kwaan, Berkeley N. Limketkai
    Nutrition in Clinical Practice.2023; 38(6): 1282.     CrossRef
  • Congenital Partial Colonic Agenesis in Dogs and Cats: Clinical, Biological, Diagnostic Imaging, Endoscopic and Histopathologic Characterization, a Retrospective Study
    Paul Remmel, Lucile Gros, Jérémy Mortier, Valérie Freiche
    Veterinary Sciences.2023; 10(9): 577.     CrossRef
  • Infective endocarditis as possible complication of endoscopic stricture dilation in Crohn's disease
    A. Gonçalves, M. Silva, S. Barbeiro, H. Vasconcelos
    Endoscopy.2023; 55(S 02): S87.     CrossRef
  • Revisiting fibrosis in inflammatory bowel disease: the gut thickens
    Silvia D’Alessio, Federica Ungaro, Daniele Noviello, Sara Lovisa, Laurent Peyrin-Biroulet, Silvio Danese
    Nature Reviews Gastroenterology & Hepatology.2022; 19(3): 169.     CrossRef
  • Medical treatment of intestinal Crohn's disease
    Eula Plana Tetangco, Adam C. Stein
    Seminars in Colon and Rectal Surgery.2022; 33(1): 100862.     CrossRef
  • Choosing the right biologic for complications of inflammatory bowel disease
    Shana Rakowsky, Konstantinos Papamichael, Adam S. Cheifetz
    Expert Review of Gastroenterology & Hepatology.2022; 16(3): 235.     CrossRef
  • The Possible Pathogenic Role of IgG4-Producing Plasmablasts in Stricturing Crohn’s Disease
    Omar Bushara, David Joseph Escobar, Samuel Edward Weinberg, Leyu Sun, Jie Liao, Guang-Yu Yang
    Pathobiology.2022; 89(4): 187.     CrossRef
  • Safety and efficacy of non-fluoroscopic endoscopic dilatation of gastrointestinal tuberculosis related strictures
    Pankaj Kumar, Anuraag Jena, Chhagan Lal Birda, Harjeet Singh, Pankaj Gupta, Kaushal Kishor Prasad, Usha Dutta, Vishal Sharma
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Endoscopic balloon dilations for strictures of rectum, ileocecal valve and duodenum in a patient with X-linked inhibitor of apoptosis deficiency: a case report
    Shinsuke Otagiri, Takehiko Katsurada, Kensuke Sakurai, Junichi Sugita, Naoya Sakamoto
    Intestinal Research.2022; 20(2): 274.     CrossRef
  • State-of-the-art surgery for Crohn’s disease: Part II—colonic Crohn’s disease and associated neoplasms
    Anne Macleod, Sandra L. Kavalukas, Katharina M. Scheurlen, Susan Galandiuk
    Langenbeck's Archives of Surgery.2022; 407(7): 2595.     CrossRef
  • The role of interleukin-33 in organ fibrosis
    Samuele Di Carmine, Molly M Scott, Mairi H McLean, Henry J McSorley
    Discovery Immunology.2022;[Epub]     CrossRef
  • Late onset crohns ileitis—A diagnostic dilemma
    Ashok Sunder, Manish Kumar, Sudip Saha, Bhagyalakshmi Satyanarayan
    Journal of Family Medicine and Primary Care.2022; 11(12): 7968.     CrossRef
  • Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis
    Lauren Sahakian, Rhiannon T Filippone, Rhian Stavely, Ainsley M Robinson, Xu Sean Yan, Raquel Abalo, Rajaraman Eri, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali
    Inflammatory Bowel Diseases.2021; 27(3): 388.     CrossRef
  • A postdischarge venous thromboembolism risk calculator for inflammatory bowel disease surgery
    Cary Jo R. Schlick, Tarik K. Yuce, Anthony D. Yang, Michael F. McGee, David J. Bentrem, Karl Y. Bilimoria, Ryan P. Merkow
    Surgery.2021; 169(2): 240.     CrossRef
  • Presence of Obstructive Symptoms and Absence of Perianal Crohn Disease Is Predictive of Surgery After Endoscopic Balloon Dilation
    Barathi Sivasailam, Scott Manski, Alicia Wentz, Raymond K Cross
    Inflammatory Bowel Diseases.2021; 27(8): 1230.     CrossRef
  • Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease
    Allison D Ta, Nicholas J Ollberding, Rebekah Karns, Yael Haberman, Adina L Alazraki, David Hercules, Robert Baldassano, James Markowitz, Melvin B Heyman, Sandra Kim, Barbara Kirschner, Jason M Shapiro, Joshua Noe, Maria Oliva-Hemker, Anthony Otley, Marian
    Inflammatory Bowel Diseases.2021; 27(11): 1707.     CrossRef
  • Infliximab therapy intensification based on endoscopic activity is related to suppress treatment discontinuation in patients with Crohn disease
    Yuga Komaki, Shuji Kanmura, Kazuki Yutsudo, Kosuke Kuwazuru, Fukiko Komaki, Akihito Tanaka, Nobuaki Nishimata, Yoichi Sameshima, Fumisato Sasaki, Hidehisa Ohi, Yuichi Nakamura, Koichi Tokushige, Yukinori Sameshima, Akio Ido
    Medicine.2021; 100(6): e24731.     CrossRef
  • Duodenal Obstruction in a Patient Previously Treated With EndoVascular Aneurysm Sealing System Repair
    Carlo Biddau, Carlo Nagliati, Michele Graziano, Lorenzo Cereser, Giovanni Terrosu, Alessandro Balani
    Vascular and Endovascular Surgery.2021; 55(8): 859.     CrossRef
  • Crohn's Disease Obstructions
    Molly M. Ford
    Clinics in Colon and Rectal Surgery.2021; 34(04): 227.     CrossRef
  • Transplantation of fecal microbiota from patients with inflammatory bowel disease and depression alters immune response and behavior in recipient mice
    Hyo-Min Jang, Jeon-Kyung Kim, Min-Kyung Joo, Yoon-Jung Shin, Chang Kyun Lee, Hyo-Jong Kim, Dong-Hyun Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
    Giuseppe Cicero, Silvio Mazziotti
    Intestinal Research.2021; 19(4): 365.     CrossRef
  • Current Topics of the Mechanism of Intestinal Fibrosis in Crohn’s Disease
    Yusuke Honzawa, Shuji Yamamoto, Makoto Okabe, Hiroshi Seno, Hiroshi Nakase
    Immuno.2021; 1(4): 574.     CrossRef
  • Worse outcomes and higher costs of care in fibrostenotic Crohn’s disease: a real-world propensity-matched analysis in the USA
    Melody Dehghan, Gabriel Wong, Edward Neuberger, Cindy Kin, Florian Rieder, K T Park
    BMJ Open Gastroenterology.2021; 8(1): e000781.     CrossRef
  • Epidemiology of fibrostenosing inflammatory bowel disease
    Joyce Wing Yan Mak, Siew Chien Ng
    Journal of Digestive Diseases.2020; 21(6): 332.     CrossRef
  • The Efficacy of Anti-Tumor Necrosis Factor Alpha for Symptomatic Stricturing Small Bowel Crohn’s Disease
    Mansour Alourfi, Mahmoud Mosli, Omar I Saadah
    Cureus.2020;[Epub]     CrossRef
  • Roles of protein ubiquitination in inflammatory bowel disease
    Yue Xiao, Qi Huang, Zherui Wu, Weilin Chen
    Immunobiology.2020; 225(6): 152026.     CrossRef
  • Chirurgie des maladies inflammatoires chroniques de l’intestin
    M. Aubert, D. Mege, L. Maggiori, Y. Panis
    EMC - Gastro-entérologie.2020; 37(3): 1.     CrossRef
  • Development, validation, and application of a novel tool to measure disease-related knowledge in patients with inflammatory bowel disease
    Hyuk Yoon, Suk-Kyun Yang, Hoonsub So, Ko Eun Lee, Sang Hyoung Park, Sung-Ae Jung, Joong Haeng Choh, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
    The Korean Journal of Internal Medicine.2019; 34(1): 81.     CrossRef
  • Unusual causes of large bowel obstruction
    Nicholas G. Farkas, Ted Joseph P. Welman, Talisa Ross, Sarah Brown, Jason J. Smith, Nikhil Pawa
    Current Problems in Surgery.2019; 56(2): 49.     CrossRef
  • TTC7A: Steward of Intestinal Health
    Sasha Jardine, Neel Dhingani, Aleixo M. Muise
    Cellular and Molecular Gastroenterology and Hepatology.2019; 7(3): 555.     CrossRef
  • Segmental dilatation following side‐to‐side isoperistaltic strictureplasty in Crohn’s disease: a note of caution
    Brendan Desmond, Ashok Gunawardene, Ben Griffiths, John Keating
    ANZ Journal of Surgery.2019;[Epub]     CrossRef
  • Small bowel strictures
    Deniz Durmush, Arthur J. Kaffes
    Current Opinion in Gastroenterology.2019; 35(3): 235.     CrossRef
  • Early Initiation of Anti-TNF is Associated with Favourable Long-term Outcome in Crohn’s Disease: 10-Year-Follow-up Data from the Swiss IBD Cohort Study
    Roy Frei, Nicolas Fournier, Jonas Zeitz, Michael Scharl, Bernhard Morell, Thomas Greuter, Philipp Schreiner, Benjamin Misselwitz, Ekaterina Safroneeva, Alain M Schoepfer, Stephan R Vavricka, Gerhard Rogler, Luc Biedermann
    Journal of Crohn's and Colitis.2019; 13(10): 1292.     CrossRef
  • Clinical Features and Prognosis of Crohn’s Disease with Upper Gastrointestinal Tract Phenotype in Chinese Patients
    Xiao-Wei Sun, Juan Wei, Zhao Yang, Xin-Xin Jin, Hai-Jun Wan, Bo-Si Yuan, Miao-Fang Yang, Jiong Liu, Fang-Yu Wang
    Digestive Diseases and Sciences.2019; 64(11): 3291.     CrossRef
  • Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency
    Young Lo, Jean Philippe Sauve, Susan C. Menzies, Theodore S. Steiner, Laura M. Sly
    Mucosal Immunology.2019; 12(5): 1187.     CrossRef
  • Occult Adenocarcinoma Arising in Crohn’s-Related Strictures: A Case Series
    Kevin Singh, Amandeep Singh, Jessica Philpott, David Liska, Keith Lai
    Crohn's & Colitis 360.2019;[Epub]     CrossRef
  • Agentes anti-factor de necrosis tumoral en enfermedad de Crohn y colitis ulcerosa: más allá de la enfermedad luminal
    Laura Núñez-Gómez, Francisco Mesonero-Gismero, Agustín Albillos-Martínez, Antonio López-Sanromán
    Gastroenterología y Hepatología.2018; 41(9): 576.     CrossRef
  • Parathyroid Hormone–Like Hormone Induces Epithelial-to-Mesenchymal Transition of Intestinal Epithelial Cells by Activating the Runt-Related Transcription Factor 2
    Shuying He, Minmin Xue, Cuiping Liu, Fang Xie, Lan Bai
    The American Journal of Pathology.2018; 188(6): 1374.     CrossRef
  • Anti-tumour necrosis factor agents in Crohn's disease and ulcerative colitis: Beyond luminal disease
    Laura Núñez-Gómez, Francisco Mesonero-Gismero, Agustín Albillos-Martínez, Antonio López-Sanromán
    Gastroenterología y Hepatología (English Edition).2018; 41(9): 576.     CrossRef
  • Long-Term Outcomes of Endoscopic Balloon Dilation for Benign Strictures in Patients with Inflammatory Bowel Disease
    Hye Won Lee, Soo Jung Park, Seong Ran Jeon, Byong Duk Ye, Jae Jun Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim
    Gut and Liver.2018; 12(5): 530.     CrossRef
  • Association of Perianal Fistulas with Clinical Features and Prognosis of Crohn's Disease in Korea: Results from the CONNECT Study
    Jaeyoung Chun, Jong Pil Im, Ji Won Kim, Kook Lae Lee, Chang Hwan Choi, Hyunsoo Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, You Sun Kim, Yoon Tae Jeen, Dong Soo Han, Won Ho Kim, Joo Sung Kim
    Gut and Liver.2018; 12(5): 544.     CrossRef
  • Computed tomography and magnetic resonance imaging in the diagnosis of the small and large intestine strictures in Crohn’s disease. Radiological semiotics and assessment of the inflammation activity
    S. E. Dubrova, G. A. Stashuk, N. V. Nikitina, Yu. K. Bogomazov
    Almanac of Clinical Medicine.2018; 46(7): 725.     CrossRef
  • A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn’s disease patients
    Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis, Catriona Sharp, Enrico Ferrero, Wouter J. de Jonge, Manon E. Wildenberg, Marcel M. A. M. Mannens, Christianne J. Buskens, Geert R. D’Haens, Peter Henneman, Anje A. te Velde, Osman El-Maarri
    PLOS ONE.2018; 13(12): e0209656.     CrossRef
  • Management of Crohn's disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease
    Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chi
    Intestinal Research.2017; 15(3): 285.     CrossRef
  • Biodegradable Stents
    Deepanshu Jain, Ejaz Mahmood, Shashideep Singhal
    Journal of Clinical Gastroenterology.2017; 51(4): 295.     CrossRef
  • Quality Indicators for Small Bowel Capsule Endoscopy
    Ki-Nam Shim, Seong Ran Jeon, Hyun Joo Jang, Jinsu Kim, Yun Jeong Lim, Kyeong Ok Kim, Hyun Joo Song, Hyun Seok Lee, Jae Jun Park, Ji Hyun Kim, Jaeyoung Chun, Soo Jung Park, Dong-Hoon Yang, Yang Won Min, Bora Keum, Bo-In Lee
    Clinical Endoscopy.2017; 50(2): 148.     CrossRef
  • Editorial: Factors Promoting Development of Fibrosis in Crohn’s Disease
    Jennifer Bailey
    Frontiers in Medicine.2017;[Epub]     CrossRef
  • Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease
    Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes, Hon Wai Koon
    BMC Gastroenterology.2017;[Epub]     CrossRef
  • Advanced Oxidation Protein Products Induce Epithelial–Mesenchymal Transition of Intestinal Epithelial Cellsviaa PKC δ-Mediated, Redox-Dependent Signaling Pathway
    Xiaoping Xu, Shibo Sun, Fang Xie, Juanjuan Ma, Jing Tang, Shuying He, Lan Bai
    Antioxidants & Redox Signaling.2017; 27(1): 37.     CrossRef
  • Incidence of and Risk Factors for Free Bowel Perforation in Patients with Crohn’s Disease
    Jong Wook Kim, Ho-Su Lee, Byong Duk Ye, Suk-Kyun Yang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Kim
    Digestive Diseases and Sciences.2017; 62(6): 1607.     CrossRef
  • Crohn’s disease presenting as gastric outlet obstruction: a therapeutic challenge?
    Faisal Inayat, Waqas Ullah, Qulsoom Hussain, Khurram Shafique
    BMJ Case Reports.2017; 2017: bcr-2016-218181.     CrossRef
  • Genetic Influences on the Development of Fibrosis in Crohn’s Disease
    Bram Verstockt, Isabelle Cleynen
    Frontiers in Medicine.2016;[Epub]     CrossRef
  • Crohn's Disease: Specific Concerns in the Elderly
    Wei-Chen Lin, Ming-Jen Chen, Cheng-Hsin Chu, Tsang-En Wang, Horng-Yuan Wang, Shou-Chuan Shih, Chen-Wang Chang
    International Journal of Gerontology.2016; 10(3): 126.     CrossRef
  • Structural and molecular features of intestinal strictures in rats with Crohn's-like disease
    Petra Talapka
    World Journal of Gastroenterology.2016; 22(22): 5154.     CrossRef
  • Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn’s Disease: Results from the CONNECT Study
    Jee Hye Kwon, Jong Pil Im, Byong Duk Ye, Jae Hee Cheon, Hyun Joo Jang, Kang Moon Lee, You Sun Kim, Sang Wook Kim, Young Ho Kim, Geun Am Song, Dong Soo Han, Won Ho Kim, Joo Sung Kim
    Gut and Liver.2016; 10(4): 595.     CrossRef
  • Small Bowel Stricture Mimicking Megacolon in a Patient with Crohn's Disease
    Samuel Raimundo Fernandes, Luís Araújo Correia, José Velosa
    GE Portuguese Journal of Gastroenterology.2016; 23(6): 319.     CrossRef
  • Factors Associated with Anxiety and Depression in Korean Patients with Inactive Inflammatory Bowel Disease
    Min Chul Kim, Yoon Suk Jung, Young Seok Song, Jung In Lee, Jung Ho Park, Chong Il Sohn, Kyu Yong Choi, Dong Il Park
    Gut and Liver.2016;[Epub]     CrossRef
  • Disease monitoring in inflammatory bowel disease
    Shannon Chang
    World Journal of Gastroenterology.2015; 21(40): 11246.     CrossRef
  • Endoskopie in Diagnose, Therapie und Nachsorge
    H. Neumann, M. F. Neurath, Raja Atreya
    MMW - Fortschritte der Medizin.2015; 157(12): 63.     CrossRef
  • Endoscopic Therapy in Inflammatory Bowel Diseases
    Helmut Neumann, Markus F. Neurath, Raja Atreya
    Visceral Medicine.2015; 31(4): 280.     CrossRef
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