Intestinal Research

Review

Colorectal neoplasia

Screening and surveillance for hereditary colorectal cancer: Hee Man Kim, Tae Il Kim; Intest Res 2024;22(2):119-130. Published online February 6, 2024; DOI: https://doi.org/10.5217/ir.2023.00112

Hereditary colorectal cancer is a type of cancer that is caused by a genetic mutation. Individuals with a family history of colorectal cancer, or who have a known hereditary syndrome, are at an increased risk of developing the disease. Screening and surveillance are important tools for managing the risk of hereditary colorectal cancer. Screening involves a combination of tests that can detect precancerous or cancerous changes in the colon and rectum. Surveillance involves regular follow-up examinations to monitor disease progression and to identify new developments. The frequency and type of screening and surveillance tests may vary depending on an individual’s risk factors, genetic profile, and medical history. However, early detection and treatment of hereditary colorectal cancer can significantly improve patient outcomes and reduce mortality rates. By implementing comprehensive screening and surveillance strategies, healthcare providers can help individuals at risk of hereditary colorectal cancer to receive timely interventions and make informed decisions about their health. Specific examples of screening and surveillance tests for hereditary colorectal cancer include colonoscopy, genetic testing, and imaging tests. In this review article, we will discuss detailed screening and surveillance of hereditary colorectal cancer.

Citations

Citations to this article as recorded by

Comparison between endoscopic resection and transanal surgery for treatment of rectal tumors: a systematic review and meta‑analysis
Chan Hyuk Park, Byung Wook Jung, Yoon Suk Jung
Intestinal Research.2026; 24(1): 38. CrossRef
Influence of Lifestyles on Polyp Burden and Cancer Development in Hereditary Colorectal Cancer Syndromes
Hye Kyung Hyun, Ji Soo Park, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim
Journal of Gastroenterology and Hepatology.2025; 40(2): 433. CrossRef
Identification of Genetic Factors Related With Nonhereditary Colorectal Polyposis and Its Recurrence Through Genome‐Wide Association Study
Jung Hyun Ji, Su Hyun Lee, Chan Il Jeon, Jihun Jang, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Sun Ha Jee, Tae Il Kim
Journal of Gastroenterology and Hepatology.2025; 40(2): 482. CrossRef
Inflammatory mechanisms in colorectal cancer: The role of cytokines and dietary inflammatory index : A review
Lana Sarajlić, Abazović Mekić, Edin Hodžić, Igor Gavrić, Salem Bajramagić, Amina Mehić, Emsad Halilović, Nedžad Firdus
Sanamed.2025; 20(1): 41. CrossRef
Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study
Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song
Journal of Translational Medicine.2025;[Epub] CrossRef
Therapeutic Colorectal Cancer Vaccines: Emerging Modalities and Translational Opportunities
Palaniyandi Muthukutty, Hyun Young Woo, So Young Yoo
Vaccines.2025; 13(7): 689. CrossRef
An Integrative Bioinformatics Approach to Investigating TIMP3 and Immune Cell Infiltration: Prognostic and Clinicopathological Implications
Neelam Bhola, Amit K. Jaiswal, Daman Saluja
International Journal of Molecular Sciences.2025; 26(18): 8867. CrossRef
Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern
Md Mohiuddin
Health Science Reports.2025;[Epub] CrossRef
Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment
Bingwen Zhou, Qingrui Liu, Chuyue Huang, Hao Chen, Pei Wang, Yueyang Lu, Shujun Jiang, Desong Kong, Lu Wang, Zhimin Fan
Scientific Reports.2025;[Epub] CrossRef
Advances in Hereditary Colorectal Cancer: How Precision Medicine Is Changing the Game
Shenghao Lin, Chenxi Zhou, Hanlin Chen, Xinlei Zhou, Hujia Yang, Leitao Sun, Leyin Zhang, Yuxin Zhang
Cancers.2025; 17(21): 3461. CrossRef
Profiles and diagnostic patterns of colorectal cancers among 602 patients attending a tertiary care center in Saudi Arabia for suspected colic disease
Kamaleldin B. Said, Khalid F. Alshammari, Ruba M. Elsaid Ahmed, Yosef M.-A. Zakout, Soha A. Moursi, Naif K. Binsaleh, Fahad M. Alshammary, Arwa A. Alotaibi, Mohammad S. Alzugahibi, Manal A. Alshammari, Fayez R. Alfouzan, AlFatih M. A. AlNajib, Amal D. Als
Current Medical Research and Opinion.2025; 41(10): 1799. CrossRef
Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol With Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial
Yunho Jung, Hyun Gun Kim, Dong-Hoon Yang, Hyoun Woo Kang, Jae Jun Park, Dong Hoon Baek, Jaeyoung Chun, Tae-Geun Gweon, Hyeon Jeong Goong, Min Seob Kwak, Hyun Jung Lee, Soo-Kyung Park, Jong Hoon Lee
Journal of Korean Medical Science.2024;[Epub] CrossRef

15,835 View
271 Download
12 Web of Science
12 Crossref

Original Article

Colorectal neoplasia

Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years: Ji Yeon Kim, Sungkyoung Choi, Taesung Park, Seul Ki Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyu Yong Choi, Dong Il Park; Intest Res 2019;17(2):253-264. Published online November 20, 2018; DOI: https://doi.org/10.5217/ir.2018.00062

Abstract PDF PubReader ePub

Background/Aims
Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea.
Methods
This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Young Adult Colorectal Screening (YCS) score was developed as an optimized risk stratification model for ACRN using multivariate analysis and was internally validated. The predictive power and diagnostic performance of YCS score was compared with those of Asia-Pacific Colorectal Screening (APCS) and Korean Colorectal Screening (KCS) scores.
Results
41,702 and 17,873 subjects were randomly allocated into the derivation and validation cohorts, respectively, by examination year. ACRN prevalence was 0.9% in both cohorts. YCS score comprised sex, age, alcohol, smoking, obesity, glucose metabolism abnormality, and family history of CRC, with score ranges of 0 to 10. In the validation cohort, ACRN prevalence was 0.6% in the low-risk tier (score, 0–4), 1.5% in the moderate-risk tier (score, 5–7), and 3.4% in the high-risk tier (score, 8–10). ACRN risk increased 2.5-fold (95%CI, 1.8–3.4) in the moderate-risk tier and 5.8-fold (95%CI, 3.4–9.8) in the high-risk tier compared with the low-risk tier. YCS score identified better balanced accuracy (53.9%) than APCS (51.5%) and KCS (50.7%) scores and had relatively good discriminative power (area under the curve=0.660).
Conclusions
YCS score based on clinical and laboratory risk factors was clinically effective and beneficial for predicting ACRN risk and targeting screening colonoscopy in adults aged <50 years.

Citations

Citations to this article as recorded by

Response to commentaries on “Performance of the Asia‐Pacific colorectal screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review”
MN Luu, DT Quach
Journal of Gastroenterology and Hepatology.2025; 40(1): 337. CrossRef
Family History of Colorectal Cancer and the Risk of Colorectal Neoplasia: A Systematic Review and Meta-Analysis
Kai Gao, Huyi Jin, Yi Yang, Jiayu Li, Yuanliang He, Ruiyao Zhou, Wanting Zhang, Xiangrong Gao, Zongming Yang, Mengling Tang, Jianbing Wang, Ding Ye, Kun Chen, Mingjuan Jin
American Journal of Gastroenterology.2025; 120(3): 531. CrossRef
Development and Internal Validation of a Machine Learning-Based Colorectal Cancer Risk Prediction Model
Deborah Jael Herrera, Daiane Maria Seibert, Karen Feyen, Marlon van Loo, Guido Van Hal, Wessel van de Veerdonk
Gastrointestinal Disorders.2025; 7(2): 26. CrossRef
Performance of the Asia–Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review
Mai Ngoc Luu, Nhi Ai Trinh, Truc Le Thanh Tran, Thinh Phuong Dang, Toru Hiyama, Duc Trong Quach
Journal of Gastroenterology and Hepatology.2024; 39(6): 1000. CrossRef
Updated epidemiology of gastrointestinal cancers in East Asia
Junjie Huang, Don Eliseo Lucero-Prisno, Lin Zhang, Wanghong Xu, Sunny H. Wong, Siew C. Ng, Martin C. S. Wong
Nature Reviews Gastroenterology & Hepatology.2023; 20(5): 271. CrossRef
From Algorithms to Clinical Utility: A Systematic Review of Individualized Risk Prediction Models for Colorectal Cancer
Deborah Jael Herrera, Wessel van de Veerdonk, Daiane Maria Seibert, Moges Muluneh Boke, Claudia Gutiérrez-Ortiz, Nigus Bililign Yimer, Karen Feyen, Allegra Ferrari, Guido Van Hal
Gastrointestinal Disorders.2023; 5(4): 549. CrossRef
Emergence of a New Optical Marker for Colorectal Neoplasms: To What Extent Should We Accept It?
Han Hee Lee
Clinical Endoscopy.2022; 55(2): 315. CrossRef
Is early-onset cancer an emerging global epidemic? Current evidence and future implications
Tomotaka Ugai, Naoko Sasamoto, Hwa-Young Lee, Mariko Ando, Mingyang Song, Rulla M. Tamimi, Ichiro Kawachi, Peter T. Campbell, Edward L. Giovannucci, Elisabete Weiderpass, Timothy R. Rebbeck, Shuji Ogino
Nature Reviews Clinical Oncology.2022; 19(10): 656. CrossRef
Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
Yoon Suk Jung
Precision and Future Medicine.2021; 5(2): 69. CrossRef
How to Choose the Optimal Bowel Preparation Regimen for Colonoscopy
Ji Eun Na, Eun Ran Kim
The Ewha Medical Journal.2021; 44(4): 122. CrossRef
The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review
Marta Puzzono, Alessandro Mannucci, Simone Grannò, Raffaella Alessia Zuppardo, Andrea Galli, Silvio Danese, Giulia Martina Cavestro
Cancers.2021; 13(23): 5933. CrossRef
Association between waist circumference and risk of colorectal neoplasia in normal‐weight adults
Yoon Suk Jung, Nam Hee Kim, Hyo‐Joon Yang, Soo‐Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Gastroenterology and Hepatology.2020; 35(1): 43. CrossRef
Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals
Ala I Sharara, Ali El Mokahal, Ali H Harb, Natalia Khalaf, Fayez S Sarkis, Mustapha M El-Halabi, Nabil M Mansour, Ahmad Malli, Robert Habib
World Journal of Gastroenterology.2020; 26(37): 5705. CrossRef
Risk Factors Associated With Young-Onset Colorectal Adenomas and Cancer: A Systematic Review and Meta-Analysis of Observational Research
Genevieve Breau, Ursula Ellis
Cancer Control.2020;[Epub] CrossRef
Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intestinal Research.2019; 17(3): 317. CrossRef

11,163 View
170 Download
14 Web of Science
15 Crossref

First
Prev
Page of 1
Next
Last

Search