The extensive study of genetic alterations in colorectal cancer (CRC) has led to molecular diagnostics playing an increasingly important role in CRC diagnosis and treatment. Currently, it is believed that CRC is a consequence of the accumulation of both genetic and epigenetic genomic alterations. It is known that there are at least 3 major pathways that lead to colorectal carcinogenesis: (1) the chromosomal instability pathway, (2) the microsatellite instability pathway, and (3) the cytosine-phospho-guanine island methylator phenotype pathway. With recent advances in CRC genetics, the identification of specific molecular alterations responsible for CRC pathogenesis has directly influences clinical care. Patients at high risk for developing CRC can be identified by genetic testing for specific molecular alterations, and the use of molecular biomarkers for predictive and prognostic purposes is also increasing. This is clearly supported by the recent advances in genetic testing for CRC whereby specific molecular alterations are identified for the purpose of guiding treatment with targeting therapies such as anti-endothelial growth factor receptor monoclonal antibodies.

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• Randomized non-inferiority single-center prospective trial of malignant colonic obstruction therapy with Self-expandable metal stent (SEMS) endoscopic placement or stoma formation
  I.E. Gorovaia, P.V. Tsarkov, P.V. Pavlov, I.A. Tulina, V.I. Zhurkovskiy
  Endoscopic Surgery.2024; 30(2): 5.     CrossRef
• Survival of colorectal cancer patients in Brunei Darussalam: comparison between 2002–09 and 2010–17
  Shirley H. F. Lee, Hanif Abdul Rahman, Nadiah Abidin, Sok King Ong, Elvynna Leong, Lin Naing
  BMC Cancer.2021;[Epub]     CrossRef
• Three-year colonoscopy surveillance after polypectomy in Korea: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter prospective study
  Won Seok Choi, Dong Soo Han, Chang Soo Eun, Dong Il Park, Jeong-Sik Byeon, Dong-Hoon Yang, Sung-Ae Jung, Sang Kil Lee, Sung Pil Hong, Cheol Hee Park, Suck-Ho Lee, Jeong-Seon Ji, Sung Jae Shin, Bora Keum, Hyun Soo Kim, Jung Hye Choi, Sin-Ho Jung
  Intestinal Research.2018; 16(1): 126.     CrossRef
• Genetic and epigenetic alterations of colorectal cancer
  Sung Noh Hong
  Intestinal Research.2018; 16(3): 327.     CrossRef
• Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma
  Su Hwan Kim, Ji Won Kim, Kook Lae Lee, Seohui Lee, Seong-Joon Koh, Ji Bong Jeong, Byeong Gwan Kim
  The American Journal of the Medical Sciences.2018; 356(2): 141.     CrossRef
• Is methylation analysis ofSFRP2,TFPI2,NDRG4, andBMP3promoters suitable for colorectal cancer screening in the Korean population?
  Soo-Kyung Park, Hae Lim Baek, Junghee Yu, Ji Yeon Kim, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jeong, Ho-Kyung Chun, Kyungeun Kim, Dong Il Park
  Intestinal Research.2017; 15(4): 495.     CrossRef
• Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway
  Sun-Young Park, Hyung-Hoon Oh, Young-Lan Park, Hyung-Min Yu, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Daeho Park, Young-Eun Joo
  International Journal of Oncology.2017; 51(3): 959.     CrossRef
• Expression of inositol-requiring enzyme 1β is downregulated in colorectal cancer
  Yalin Jiang, Yunfeng Zhou, Yufeng Zheng, Hong Guo, Lei Gao, Pan Chen, Dandan Feng, Ran Qi, Xiaozhen Li, Yongchao Chang, Fong-Fong Chu, Qiang Gao
  Oncology Letters.2017; 13(3): 1109.     CrossRef
• Obesity-related parameters and colorectal adenoma development
  Tae Jun Kim, Jee Eun Kim, Yoon-Ho Choi, Sung Noh Hong, Young-Ho Kim, Dong Kyung Chang, Poong-Lyul Rhee, Min-Ji Kim, Sin-Ho Jung, Hee Jung Son
  Journal of Gastroenterology.2017; 52(12): 1221.     CrossRef
• The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance
  Abdo Alnabulsi, Rebecca Swan, Beatriz Cash, Ayham Alnabulsi, Graeme I Murray
  British Journal of Cancer.2017; 116(12): 1612.     CrossRef
• Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer
  Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Hajime Morohashi, Kenichi Hakamada, Shuji Terai, Hiroshi Kijima
  Oncology Reports.2016; 36(3): 1251.     CrossRef
• Fecal hemoglobin concentration is useful for risk stratification of advanced colorectal neoplasia
  Nam Hee Kim, Min-Jung Kwon, Hyun-young Kim, Taeheon Lee, Seok Hyeon Jeong, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
  Digestive and Liver Disease.2016; 48(6): 667.     CrossRef
• Statin use and the risk of colorectal adenoma: A meta‐analysis
  Yoon Suk Jung, Chan Hyuk Park, Chang Soo Eun, Dong Il Park, Dong Soo Han
  Journal of Gastroenterology and Hepatology.2016; 31(11): 1823.     CrossRef
• Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer
  NURI KIM, SUNG-BUM CHO, YOUNG-LAN PARK, SUN-YOUNG PARK, EUN MYUNG, SEUNG-HUN KIM, HYUNG-MIN YU, YOUNG-AE SON, DAE-SEONG MYUNG, WAN-SIK LEE, YOUNG-EUN JOO
  Oncology Reports.2016; 35(6): 3331.     CrossRef
• Field Cancerization in Sporadic Colon Cancer
  Soo-Kyung Park, Chang Seok Song, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Dong Hoe Koo, Kyung Eun Kim, Kyung Uk Jeong, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Dong Il Park
  Gut and Liver.2016; 10(5): 773.     CrossRef
• Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer
  HYUNG-HOON OH, KANG-JIN PARK, NURI KIM, SUN-YOUNG PARK, YOUNG-LAN PARK, CHAN-YOUNG OAK, DAE-SEONG MYUNG, SUNG-BUM CHO, WAN-SIK LEE, KYUNG-KEUN KIM, YOUNG-EUN JOO
  Oncology Reports.2016; 35(1): 253.     CrossRef
• Risk Factors Such as Male Sex, Smoking, Metabolic Syndrome, Obesity, and Fatty Liver Do Not Justify Screening Colonoscopies Before Age 45
  Yoon Suk Jung, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park
  Digestive Diseases and Sciences.2016; 61(4): 1021.     CrossRef
• Does Low Threshold Value Use Improve Proximal Neoplasia Detection by Fecal Immunochemical Test?
  Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
  Digestive Diseases and Sciences.2016; 61(9): 2685.     CrossRef
• Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients
  Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim
  Medicine.2016; 95(19): e3641.     CrossRef
• Does Stenting as a Bridge to Surgery in Left-Sided Colorectal Cancer Obstruction Really Worsen Oncological Outcomes?
  Min Seob Kwak, Wan Soo Kim, Jeong-Mi Lee, Dong-Hoon Yang, Yong Sik Yoon, Chang Sik Yu, Jin Cheon Kim, Jeong-Sik Byeon
  Diseases of the Colon & Rectum.2016; 59(8): 725.     CrossRef
• Risk of Advanced Colorectal Neoplasia According to the Number of High-Risk Findings at Index Colonoscopy: A Korean Association for the Study of Intestinal Disease (KASID) Study
  Yoon Suk Jung, Dong Il Park, Won Hee Kim, Chang Soo Eun, Soo-Kyung Park, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yunho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee
  Digestive Diseases and Sciences.2016; 61(6): 1661.     CrossRef
• Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps
  Taeyoung Lee, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
  Digestive Diseases and Sciences.2016; 61(1): 317.     CrossRef
• Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm
  Yoon Suk Jung, Hwanseok Jung, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park, Kyuyong Choi
  Journal of Gastroenterology and Hepatology.2016; 31(4): 788.     CrossRef
• Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
  Young-Lan Park, Sun-Young Park, Seung-Hyun Lee, Rul-Bin Kim, Joong-Keun Kim, Sung-Yoon Rew, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo
  Oncotarget.2016; 7(44): 72229.     CrossRef
• Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer
  Rebecca Swan, Abdo Alnabulsi, Beatriz Cash, Ayham Alnabulsi, Graeme I. Murray
  Oncotarget.2016; 7(29): 46509.     CrossRef
• Associations Between Parameters of Glucose and Lipid Metabolism and Risk of Colorectal Neoplasm
  Yoon Suk Jung, Seungho Ryu, Yoosoo Chang, Kyung Eun Yun, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyuyong Choi, Dong Il Park
  Digestive Diseases and Sciences.2015; 60(10): 2996.     CrossRef
• Clinical Features and Prognosis of Resectable Primary Colorectal Signet-Ring Cell Carcinoma
  Ho-Su Lee, Jae Seung Soh, Seohyun Lee, Jung Ho Bae, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sun A Kim, Young Soo Park, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Dong-Hoon Yang
  Intestinal Research.2015; 13(4): 332.     CrossRef
• Global impact of KRAS mutation patterns in FOLFOX treated metastatic colorectal cancer
  David M. Zocche, Carolina Ramirez, Fernando M. Fontao, Lucas D. Costa, María A. Redal
  Frontiers in Genetics.2015;[Epub]     CrossRef
• Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer
  Jia-jun Qiu, Jing-bin Yan
  Tumor Biology.2015; 36(9): 7175.     CrossRef
• Prognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
  Young-Eun Joo
  Gut and Liver.2015; 9(2): 139.     CrossRef
• Serrated Polyps and Their Alternative Pathway to the Colorectal Cancer: A Systematic Review
  Łukasz Szylberg, Marlena Janiczek, Aneta Popiel, Andrzej Marszałek
  Gastroenterology Research and Practice.2015; 2015: 1.     CrossRef
• Correlational research of Golgi phosphorylation protein 3 expression in colorectal cancer
  Yan-Ta Guo
  World Journal of Gastroenterology.2015; 21(48): 13473.     CrossRef
• Initial Results of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome
  Dt R. Howarth, Sharon S. Lum, Pamela Esquivel, Carlos A. Garberoglio, Maheswari Senthil, Naveenraj L. Solomon
  The American Surgeon™.2015; 81(10): 941.     CrossRef
• Glycoprotein A33 deficiency: a new model of impaired intestinal epithelial barrier function and inflammatory disease
  Benjamin B. Williams, Niall C. Tebbutt, Michael Buchert, Tracy L. Putoczki, Karen Doggett, Shisan Bao, Cameron N. Johnstone, Frederick Masson, Frederic Hollande, Antony W. Burgess, Andrew M. Scott, Matthias Ernst, Joan K. Heath
  Disease Models & Mechanisms.2015;[Epub]     CrossRef