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Microbiota
Exploring the link between celiac disease and obesity: a potential role of gut microbiome
Sunaina Addanki, Anastasia Mashukova, Arkene Levy
Intest Res 2025;23(2):193-201.   Published online November 8, 2024
DOI: https://doi.org/10.5217/ir.2024.00049
AbstractAbstract PDFPubReaderePub
Background/Aims
In today’s age, celiac disease (CD) is no longer solely characterized by chronic diarrhea in a malnourished child. Obesity is gradually being acknowledged as part of CD’s clinical course. Both conditions have been linked to alterations of gut microbiome. Given the difficulty of strict gluten-free diet adherence, there is a need for less restrictive adjunctive therapies. We aimed to investigate the prevalence of obesity in patients diagnosed with CD with the goal of developing new therapeutic approaches.
Methods
Baseline data from the National Institute of Health’s All of Us Research Program, was used to evaluate the relationship between CD and obesity. A retrospective cohort study was conducted where groups of individuals with CD and without CD were matched by age range and health surveys. Statistical analysis with odds ratios (OR) with 95% confidence intervals (CI) were reported.
Results
The prevalence of obesity was 32.6% in the CD group compared to 18.4% in the control group (OR, 2.111; 95% CI, 1.914–2.328; P< 0.0001). Women accounted for a greater population of patients with CD and obesity. The largest percentage of patients with CD and obesity were older than 65 years. The highest percentage of individuals in both the experimental and control groups were white, followed by African Americans.
Conclusions
Our data shows a significant association between CD and increased prevalence of obesity. These results warrant further investigation into microbial changes and dietary exposures that affect the pathogenesis of both diseases.

Citations

Citations to this article as recorded by  
  • Celiac Disease and Metabolic Diseases: A Review of Emerging Connections
    Deirdre Reidy, Christopher Cao, Alexandra Rosenstock, Melissa Stoffels, Sonal Kumar, Haley M. Zylberberg
    Current Treatment Options in Gastroenterology.2025;[Epub]     CrossRef
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  • 1 Crossref
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Functional bowel disorders
Evaluation of symptoms and symptom combinations in histamine intolerance
Wolfgang J. Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Sandra J. Holasek, Harald Mangge
Intest Res 2019;17(3):427-433.   Published online March 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00152
AbstractAbstract PDFPubReaderePub
Background/Aims
Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT.
Methods
In an analysis of outpatients’ charts we identified 133 patients, who presented with recurring nonspecific functional gastrointestinal, extraintestinal symptoms, and a diamine oxidase value <10 U/mL, indicative of HIT. A standardized anonymous questionnaire with symptoms of HIT based on known symptoms and the 4 histamine receptors including gastrointestinal, cardiovascular, respiratory and skin complaints was developed, and sent by mail to the patients.
Results
In the 62 patients that completed the questionnaire bloating was the most common and most serious symptom. Other commonly reported gastrointestinal symptoms were postprandial fullness, diarrhea, abdominal pain, and constipation. The presence of 2 from a list of 24 symptoms resulted in 276 various symptom combinations. From calculated 2.024 possible combinations of 3 symptoms the patients with HIT presented 1.975 combinations.
Conclusions
The knowledge of this wide variability of symptoms and complex symptom combinations in patients with HIT may help to clinically recognize and diagnose HIT.

Citations

Citations to this article as recorded by  
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    József Tamasi, László Kalabay
    Journal of Clinical Medicine.2025; 14(2): 311.     CrossRef
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    Gabriele Frost, Christian Lutz, Andreas Schwiertz, Hermann Huber, Albert Missbichler
    Analytical Biochemistry.2025; 702: 115819.     CrossRef
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    Doina Georgescu, Daniel Lighezan, Mihai Ionita, Paul Ciubotaru, Gabriel Cozma, Alexandra Faur, Ioana Suceava, Oana Elena Ancusa, Roxana Buzas
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    Gerardo Gilligan, María Fernanda Galindez‐Costa
    Oral Diseases.2025;[Epub]     CrossRef
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    Gregory Hage, Yonna Sacre, Joanne Haddad, Marcel Hajj, Lea Nicole Sayegh, Nicole Fakhoury-Sayegh
    Nutrients.2025; 17(8): 1359.     CrossRef
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    Takashi Nakamura, Hirohisa Fujikawa, Hirotake Ikeda, Satoshi Mizuma
    Cureus.2025;[Epub]     CrossRef
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    Martin Fuchs
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    Adriana Duelo, Oriol Comas-Basté, Sònia Sánchez-Pérez, M. Teresa Veciana-Nogués, Eva Ruiz-Casares, M. Carmen Vidal-Carou, M. Luz Latorre-Moratalla
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    Christoph Jochum
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    Yeşim Öztekin
    İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi.2024; (22): 446.     CrossRef
  • A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study
    Gaurav Singh, Indresh Dixit, Douglas Kalman, Naga Tejaswi Gogineni
    Journal of the American Nutrition Association.2024; 43(6): 553.     CrossRef
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    Cheryl Iny Harris, Bonnie Nasar, Celeste C. Finnerty
    Journal of the Academy of Nutrition and Dietetics.2024; 124(11): 1387.     CrossRef
  • The Factors Influencing the Concentration of Histamine in Jarred Baby Foods Containing Fish, Considering Evaluation of Daily Histamine Intake
    Marta Buczkowska, Anna Szczyrba, Dominika Szajnoga, Michał Górski, Jolanta Malinowska-Borowska, Joanna Domagalska, Piotr Rozentryt
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  • Cutaneous mastocytosis: diagnostic challenges and dietary influences in a prolonged case report
    Lina Al-Soufi, Aya Marashli, Rahaf Chukri HajBakri, Zuheir Al-Shehabi
    Dermatology Reports.2024;[Epub]     CrossRef
  • Study Protocol for a Prospective, Unicentric, Double-Blind, Randomized, and Placebo-Controlled Trial on the Efficacy of a Low-Histamine Diet and DAO Enzyme Supplementation in Patients with Histamine Intolerance
    Adriana Duelo, Sònia Sánchez-Pérez, Ana Ruiz-Leon, Francesc Casanovas-Garriga, Salvador Pellicer-Roca, Irache Iduriaga-Platero, Judit Costa-Catala, M. Veciana-Nogués, Joaquim Fernández-Solà, Rosa Muñoz-Cano, Joan Bartra, Andrea Combalia, Oriol Comas-Basté
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  • Focus on histamine production during cheese manufacture and processing: A review
    Maria Carmela Ferrante, Raffaelina Mercogliano
    Food Chemistry.2023; 419: 136046.     CrossRef
  • Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study
    Gülşah Okutan, Teresa Perucho Alcalde, Eva Ruiz Casares, Bruno F. Penadés, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Lorena Torrente Estríngana, Adriana Duelo, Ismael San Mauro Martín
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Food Fermentation Technology: Examples of application in Malaysian Foods
    Genevie Eleanor Ruby, Noor Azira Abdul Mutalib, Nurul Hanisah Juhari, Ungku Fatimah Ungku Zainal Abidin
    Food and Humanity.2023; 1: 32.     CrossRef
  • Histamine intolerance and irritable bowel syndrome
    Yu.A. Golubeva, A.F. Sheptulina, O.M. Drapkina
    Russian Journal of Preventive Medicine.2023; 26(6): 130.     CrossRef
  • Functional Abdominal Pain Disorders in Children May Be Associated with Food Intolerance/Malabsorption
    Wolfgang J. Schnedl, Michael Schenk, Simon Michaelis, Dietmar Enko, Harald Mangge
    Children.2023; 10(9): 1444.     CrossRef
  • Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability
    Jason R. Bush, Jun Han, Edward C. Deehan, Scott V. Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett
    Journal of Functional Foods.2023; 108: 105740.     CrossRef
  • Placebo-Controlled Histamine Challenge Disproves Suspicion of Histamine Intolerance
    Rebekka Karolin Bent, Claudia Kugler, Valentina Faihs, Ulf Darsow, Tilo Biedermann, Knut Brockow
    The Journal of Allergy and Clinical Immunology: In Practice.2023; 11(12): 3724.     CrossRef
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    Gülşah Okutan, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Ismael San Mauro Martín
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  • Diamine Oxidase Interactions with Anti-Inflammatory and Anti-Migraine Medicines in the Treatment of Migraine
    Yaiza Tobajas, Marc Alemany-Fornés, Iris Samarra, Jordi Romero-Giménez, Maria Tintoré, Antoni del Pino, Núria Canela, Josep M. del Bas, Nàdia Ortega-Olivé, Carlos de Lecea, Xavier Escoté
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    Olaf Michel
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    Revista Alergia México.2023; 70(4): 265.     CrossRef
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    Valentina Cucca, Giuseppe A. Ramirez, Patrizia Pignatti, Chiara Asperti, Marco Russo, Emanuel Della-Torre, Daniela Breda, Samuele E. Burastero, Lorenzo Dagna, Mona-Rita Yacoub
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  • Serum Diamine Oxidase Values, Indicating Histamine Intolerance, Influence Lactose Tolerance Breath Test Results
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    Darrell O. Ricke
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    Sònia Sánchez-Pérez, Oriol Comas-Basté, Adriana Duelo, M. Teresa Veciana-Nogués, Mercedes Berlanga, M. Carmen Vidal-Carou, M. Luz Latorre-Moratalla
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  • Improvement of digestive symptoms in fibromyalgia patients following a diet modification according to histamine release test – an observational study
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    Rheumatology.2022; 60(3): 209.     CrossRef
  • Considering histamine in functional gastrointestinal disorders
    Wolfgang J. Schnedl, Dietmar Enko
    Critical Reviews in Food Science and Nutrition.2021; 61(17): 2960.     CrossRef
  • Non-responsive celiac disease may coincide with additional food intolerance/malabsorption, including histamine intolerance
    Wolfgang J. Schnedl, Harald Mangge, Michael Schenk, Dietmar Enko
    Medical Hypotheses.2021; 146: 110404.     CrossRef
  • Histamine accumulation in dairy products: Microbial causes, techniques for the detection of histamine‐producing microbiota, and potential solutions
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  • Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns
    Domenico Gargano, Ramapraba Appanna, Antonella Santonicola, Fabio De Bartolomeis, Cristiana Stellato, Antonella Cianferoni, Vincenzo Casolaro, Paola Iovino
    Nutrients.2021; 13(5): 1638.     CrossRef
  • Food Intolerance: The Role of Histamine
    Yulia O. Shulpekova, Vladimir M. Nechaev, Irina R. Popova, Tatiana A. Deeva, Arthur T. Kopylov, Kristina A. Malsagova, Anna L. Kaysheva, Vladimir T. Ivashkin
    Nutrients.2021; 13(9): 3207.     CrossRef
  • The cold chain and the COVID-19 pandemic: an unusual increase in histamine content in fish samples collected in Southern Italy during lockdown
    Francesco Giuseppe Galluzzo, Gaetano Cammilleri, Antonello Cicero, Licia Pantano, Andrea Pulvirenti, Andrea Macaluso, Nicola Cicero, Vittorio Calabrese, Vincenzo Ferrantelli
    Food Quality and Safety.2021;[Epub]     CrossRef
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    Nevio Cimolai
    Intestinal Research.2020; 18(1): 134.     CrossRef
  • Lyophilised legume sprouts as a functional ingredient for diamine oxidase enzyme supplementation in histamine intolerance
    Oriol Comas-Basté, M. Luz Latorre-Moratalla, Judit Rabell-González, M. Teresa Veciana-Nogués, M. Carmen Vidal-Carou
    LWT.2020; 125: 109201.     CrossRef
  • Histamine Intolerance: The Current State of the Art
    Oriol Comas-Basté, Sònia Sánchez-Pérez, Maria Teresa Veciana-Nogués, Mariluz Latorre-Moratalla, María del Carmen Vidal-Carou
    Biomolecules.2020; 10(8): 1181.     CrossRef
  • Increasing Expiratory Hydrogen in Lactose Intolerance Is Associated with Additional Food Intolerance/Malabsorption
    Wolfgang J. Schnedl, Nathalie Meier-Allard, Sonja Lackner, Dietmar Enko, Harald Mangge, Sandra J. Holasek
    Nutrients.2020; 12(12): 3690.     CrossRef
  • Interdisciplinary Significance of Food-Related Adverse Reactions in Adulthood
    Dóra Solymosi, Miklós Sárdy, Györgyi Pónyai
    Nutrients.2020; 12(12): 3725.     CrossRef
  • Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles
    Armelle Tchoumi Neree, Rodolphe Soret, Lucia Marcocci, Paola Pietrangeli, Nicolas Pilon, Mircea Alexandru Mateescu
    Scientific Reports.2020;[Epub]     CrossRef
  • Diamine oxidase supplementation improves symptoms in patients with histamine intolerance
    Wolfgang J. Schnedl, Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge, Florian Forster
    Food Science and Biotechnology.2019; 28(6): 1779.     CrossRef
  • Food Intolerances
    Caroline J Tuck, Jessica R Biesiekierski, Peter Schmid-Grendelmeier, Daniel Pohl
    Nutrients.2019; 11(7): 1684.     CrossRef
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  • 586 Download
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  • 63 Crossref
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Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled trial
Vinay G Zanwar, Sunil V Pawar, Pravir A Gambhire, Samit S Jain, Ravindra G Surude, Vinaya B Shah, Qais Q Contractor, Pravin M Rathi
Intest Res 2016;14(4):343-350.   Published online October 17, 2016
DOI: https://doi.org/10.5217/ir.2016.14.4.343
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms.

Methods

We performed a double-blind randomized placebo-controlled rechallenge trial in a tertiary care hospital with IBS patients who fulfilled the Rome III criteria. Patients with celiac disease and wheat allergy were appropriately excluded. The participants were administered a gluten-free diet for 4 weeks and were asked to complete a symptom-based questionnaire to assess their overall symptoms, abdominal pain, bloating, wind, and tiredness on the visual analog scale (0-100) at the baseline and every week thereafter. The participants who showed improvement were randomly assigned to one of two groups to receive either a placebo (gluten-free breads) or gluten (whole cereal breads) as a rechallenge for the next 4 weeks.

Results

In line with the protocol analysis, 60 patients completed the study. The overall symptom score on the visual analog scale was significantly different between the two groups (P<0.05). Moreover, the patients in the gluten intervention group scored significantly higher in terms of abdominal pain, bloating, and tiredness (P<0.05), and their symptoms worsened within 1 week of the rechallenge.

Conclusions

A gluten diet may worsen the symptoms of IBS patients. Therefore, some form of gluten sensitivity other than celiac disease exists in some of them, and patients with IBS may benefit from gluten restrictions.

Citations

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