Intestinal Research

Focused Review

IBD

Recent advance in very early-onset inflammatory bowel disease: Jung Ok Shim; Intest Res 2019;17(1):9-16. Published online November 12, 2018; DOI: https://doi.org/10.5217/ir.2018.00130

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with infantile-onset IBD have high rates of affected first-degree relatives and severe disease course. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD.

Citations

Citations to this article as recorded by

Familial Mediterranean fever in Armenian children with inflammatory bowel disease
Gayane Amaryan, Tamara Sarkisian, Artashes Tadevosyan, Christian Braegger
Frontiers in Pediatrics.2024;[Epub] CrossRef
Allergic manifestations in autoimmune gastrointestinal disorders
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Giovanni Santacroce, Antonio Di Sabatino
Autoimmunity Reviews.2022; 21(1): 102958. CrossRef
Nutritional characteristic of children with inflammatory bowel disease in the nationwide inflammatory bowel disease registry from the Mediterranean region
Zarife Kuloglu, Funda Çetin, Nafiye Urgancı, Zerrin Önal, Sinan Sarı, Hasan Yüksekkaya, Gönül Çaltepe, Günsel Kutluk, Ebru Dumlupinar, Mustafa Akçam, Duran Arslan, Nur Arslan, Reha Artan, Ayşen Uncuoğlu Aydoğan, Necati Balamtekin, Maşallah Baran, Gökhan B
European Journal of Clinical Nutrition.2022; 76(9): 1289. CrossRef
Novel biallelic mutations in the DUOX2 gene underlying very early-onset inflammatory bowel disease: A case report
Reiko Kyodo, Ichiro Takeuchi, Satoshi Narumi, Hirotaka Shimizu, Kenichiro Hata, Takako Yoshioka, Kanako Tanase-Nakao, Toshiaki Shimizu, Katsuhiro Arai
Clinical Immunology.2022; 238: 109015. CrossRef
High initial bowel resection rate and very-early-onset inflammatory bowel disease – A challenge in a low-prevalence area
Pai-Jui Yeh, Chien-Chang Chen, Hsun-Chin Chao, Jin-Yao Lai, Chuen Hsueh, Chao-Jan Wang, Ming-Wei Lai
Journal of the Formosan Medical Association.2021; 120(1): 720. CrossRef
IBDs and the pediatric age: Their peculiarities and the involvement of the microbiota
Lucia Cococcioni, Simona Panelli, Ilaria Varotto-Boccazzi, Domenico Di Carlo, Dario Pistone, Gabriella Leccese, Gian Vincenzo Zuccotti, Francesco Comandatore
Digestive and Liver Disease.2021; 53(1): 17. CrossRef
Novel TNFAIP3 microdeletion in a girl with infantile-onset inflammatory bowel disease complicated by a severe perianal lesion
Kosuke Taniguchi, Mikihiro Inoue, Katsuhiro Arai, Keiichi Uchida, Osuke Migita, Yui Akemoto, Junya Hirayama, Ichiro Takeuchi, Hirotaka Shimizu, Kenichiro Hata
Human Genome Variation.2021;[Epub] CrossRef
How Can We Do Transition Successfully from Pediatric to Adult Clinics in Inflammatory Bowel Disease?
Mi Jin Kim, Sung Noh Hong, Young-Ho Kim, Yon Ho Choe
The Korean Journal of Gastroenterology.2021; 77(5): 227. CrossRef
Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease
Sang Hyoung Park, Sung Wook Hwang, Byong Duk Ye, Soomin Noh, Jae Cheol Park, Jin Yong Kim, Jeongseok Kim, Nam Seok Ham, Eun Hye Oh, Dong‐Hoon Yang, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang
Journal of Gastroenterology and Hepatology.2020; 35(6): 988. CrossRef
X-linked inhibitor of apoptosis protein deficiency complicated with Crohn's disease-like enterocolitis and Takayasu arteritis: A case report
Ichiro Takeuchi, Toshinao Kawai, Meika Nambu, Ohsuke Migita, Satoshi Yoshimura, Kenichi Nishimura, Takako Yoshioka, Masao Ogura, Reiko Kyodo, Hirotaka Shimizu, Shuichi Ito, Motohiro Kato, Masafumi Onodera, Kenichiro Hata, Yoichi Matsubara, Katsuhiro Arai
Clinical Immunology.2020; 217: 108495. CrossRef

9,004 View
418 Download
13 Web of Science
10 Crossref

Original Articles

Microbiota

Development and diversity of lactic acid producing bacteria and bifidobacteria in healthy full term Indian infants from Himachal Pradesh: Sampan Attri, Rishi Mahajan, Gunjan Goel; Intest Res 2018;16(4):529-536. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00050

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
The initial microbial colonization is a crucial step for the healthy development of an infant. Previous studies from India reported the dominance of target microbial species among Indian infants without any analysis on the diversity of target groups. This is the first study from India with an objective to investigate the establishment and diversity of lactic acid producing bacteria (LAB) and bifidobacteria in vaginally delivered, full term, breastfed infants for the first 4 months after birth.
Methods
Present study used polymerase chain reaction-denaturating gradient gel electrophoresis (PCR-DGGE) based sequence analysis of LAB and bifidobacteria in healthy infants. The results were used to compare the development and early colonization by LAB and bifidobacteria using diversity indices during the initial months of development of gut microbiota in infants.
Results
During the first 4 months, the Shannon diversity index (H) of LAB increased from 1.16 to 1.318 and for bifidobacteria the H increased from 0.975 to 1.293 (P<0.05). Higher Sorenson’s pair wise similarity coefficient was observed for LAB and bifidobacteria during 2nd and the 3rd month. The species of the genera Enterococcus, Streptococcus, and Lactobacillus were dominant among the LAB group whereas Bifidobacterium breve was dominant species among Bifidobacterium group.
Conclusions
Our results indicate that in breast fed infants, the microbial diversity of LAB and bifidobacteria increased during the period of study.

Citations

Citations to this article as recorded by

Development and Functions of the Infant Gut Microflora: Westernvs. Indian Infants
Lalit Bharadia, Neha Agrawal, Nandan Joshi
International Journal of Pediatrics.2020; 2020: 1. CrossRef

7,554 View
133 Download
1 Web of Science
1 Crossref

Intestinal barrier integrity and function in infants with cholestasis: Nagla H. Abu Faddan, Tahra M. K. Sherif, Omnia A. Mohammed, Khalid A. Nasif, Ebtesam M. El Gezawy; Intest Res 2017;15(1):118-123. Published online January 31, 2017; DOI: https://doi.org/10.5217/ir.2017.15.1.118

Abstract PDF PubReader ePub

<b>Background/Aims</b><br/>

The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability.

Methods

This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactate were measured in all subjects.

Results

Both groups of patients with neonatal hepatitis and biliary atresia showed significantly higher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the cases and controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were found in the cholestatic infants.

Conclusions

The intestinal epithelial barrier integrity is breached nearly in all parts of the intestine in infants with cholestasis. Further research is recommended to determine the impact of this finding on the management of these infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for further research.

Citations

Citations to this article as recorded by

The association of human milk intake and outcomes in biliary atresia
Mary Elizabeth M. Tessier, Jeremy M. Schraw, Stacey Beer, Sanjiv Harpavat, M. Kyle Jensen, John C. Magee, Vicky Ng, Michael E. Scheurer, Sarah A. Taylor, Benjamin L. Shneider
Journal of Pediatric Gastroenterology and Nutrition.2025; 80(1): 163. CrossRef
Data-independent acquisition-based blood proteomics unveils predictive biomarkers for neonatal necrotizing enterocolitis
Feng Chen, Kezhe Tan, Zhibao Lv, Faling Chen, Weijue Xu, Xiaohui Gong, Li Lu, Hailiang Sun, Qinqin Fu, Wenjun Zhuang
Analytical and Bioanalytical Chemistry.2025; 417(1): 199. CrossRef
Biliary atresia: the role of gut microbiome, and microbial metabolites
Sansan Feng, Yongkang Cheng, Chuqiao Sheng, Chunfeng Yang, Yumei Li
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Modulating intestinal barrier function by sphingosine-1-phosphate receptor 1 specific agonist SEW2871 attenuated ANIT-induced cholestatic hepatitis via the gut-liver axis
Tingting Yang, Lin Li, Jiale Pang, Cai Heng, Chujing Wei, Xue Wang, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang
International Immunopharmacology.2023; 125: 111150. CrossRef
Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer
Chenchen Bi, Geqiong Xiao, Chunyan Liu, Junwei Yan, Jiaqi Chen, Wenzhang Si, Jian Zhang, Zheng Liu
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Noninvasive Biomarkers of Gut Barrier Function in Patients Suffering from Diarrhea Predominant-IBS: An Update
Michele Linsalata, Giuseppe Riezzo, Caterina Clemente, Benedetta D’Attoma, Francesco Russo, Roberta Rizzo
Disease Markers.2020; 2020: 1. CrossRef
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis
Eleanor A Fallon, Bethany M Biron-Girard, Chun-Shiang Chung, Joanne Lomas-Neira, Daithi S Heffernan, Sean F Monaghan, Alfred Ayala
Journal of Leukocyte Biology.2018; 103(6): 1151. CrossRef

6,267 View
60 Download
11 Web of Science
7 Crossref

First
Prev
Page of 1
Next
Last

Search