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Original Article
IBD
Intestinal ultrasound for intestinal Behçet disease reflects endoscopic activity and histopathological findings
Katsuki Yaguchi, Reiko Kunisaki, Sho Sato, Kaori Hirai, Misato Izumi, Yoshimi Fukuno, Mami Tanaka, Mai Okazaki, Rongrong Wu, Yurika Nishikawa, Yusuke Matsune, Shunsuke Shibui, Yoshinori Nakamori, Masafumi Nishio, Mao Matsubayashi, Tsuyoshi Ogashiwa, Ayako Fujii, Kenichiro Toritani, Hideaki Kimura, Eita Kumagai, Yukiko Sasahara, Yoshiaki Inayama, Satoshi Fujii, Toshiaki Ebina, Kazushi Numata, Shin Maeda
Intest Res 2024;22(3):297-309.   Published online July 16, 2024
DOI: https://doi.org/10.5217/ir.2023.00129
AbstractAbstract PDFPubReaderePub
Background/Aims
Intestinal Behçet disease is typically associated with ileocecal punched-out ulcers and significant morbidity and mortality. Intestinal ultrasound is a noninvasive imaging technique for disease monitoring. However, no previous reports have compared intestinal ultrasound with endoscopic ulcer activity or histopathological findings for intestinal Behçet disease. We evaluated the usefulness of intestinal ultrasound for assessing the activity of ileocecal ulcers in intestinal Behçet disease.
Methods
We retrospectively compared intestinal ultrasound findings with 73 corresponding endoscopic images and 6 resected specimens. The intestinal ultrasound findings were assessed for 7 parameters (bowel wall thickness, vascularity [evaluated using the modified Limberg score with color Doppler], bowel wall stratification, white-plaque sign [strong hyperechogenic lines or spots], mesenteric lymphadenopathy, extramural phlegmons, and fistulas), and endoscopic ulcer activity was classified into active, healing, and scar stages. Histopathological findings were evaluated by consensus among experienced pathologists.
Results
Bowel wall thickness (P< 0.001), vascularity (P< 0.001), loss of bowel wall stratification (P= 0.015), and white-plague sign (P= 0.013) were significantly exacerbated in the endoscopic active ulcer stage. Receiver operating characteristic curve analysis revealed that a bowel wall thickness of > 5.5 mm (sensitivity 89.7%, specificity 85.3%) was potentially useful for detecting active lesions. When compared with histopathological findings, an increase in bowel wall thickness reflected the ulcer marginal ridge, and the white-plaque sign reflected the ulcer bottom.
Conclusions
Intestinal ultrasound is useful for monitoring intestinal ulcer activity in intestinal Behçet disease.
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Case Report
Miscellaneous
Endoscopic balloon dilations for strictures of rectum, ileocecal valve and duodenum in a patient with X-linked inhibitor of apoptosis deficiency: a case report
Shinsuke Otagiri, Takehiko Katsurada, Kensuke Sakurai, Junichi Sugita, Naoya Sakamoto
Intest Res 2022;20(2):274-277.   Published online February 8, 2022
DOI: https://doi.org/10.5217/ir.2021.00029
AbstractAbstract PDFPubReaderePub
X-linked inhibitor of apoptosis (XIAP) deficiency is a rare primary immunodeficiency and gastrointestinal (GI) lesions in XIAP deficiency are similar to Crohn’s disease. For patients with Crohn’s disease, endoscopic balloon dilation (EBD) is known to be a standard procedure for intestinal strictures including upper GI tract. However, there are no articles which mention the efficacy of EBDs for the strictures in upper GI tract in patients with XIAP deficiency. Herein, we describe an 18-year-old male with XIAP deficiency in whom EBDs for the rectum, ileocecal valve (ICV), and duodenum were performed. Before hematopoietic stem cell transplantation (HSCT), GI endoscopy revealed strictures of the rectum, ICV and duodenum with active ulcers. Although these ulcers healed after HSCT, the strictures progressed. Therefore, we performed EBDs for the strictures of the rectum, ICV, and duodenum. In contrast studies, we did not find any other strictures in the small intestine. Throughout the patient’s clinical course, no complications of EBD occurred. He started eating after EBDs, but abdominal symptoms did not relapse without any dietary restrictions. Our case suggests that EBD could be an effective and safe procedure for intestinal strictures including upper GI tract after HSCT in patients with XIAP deficiency.
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Review
IBD
Endoscopic molecular imaging in inflammatory bowel disease
Nam Seok Ham, Seung-Jae Myung
Intest Res 2021;19(1):33-44.   Published online April 20, 2020
DOI: https://doi.org/10.5217/ir.2019.09175
AbstractAbstract PDFPubReaderePub
Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providing characterization for patient stratification and assessing the response to molecular targeted therapy. In inflammatory bowel disease, endoscopic molecular imaging can be used to assess disease severity and predict therapeutic response and prognosis. Endoscopic molecular imaging is also able to visualize dysplasia in the presence of background inflammation. Several preclinical and clinical trials have evaluated endoscopic molecular imaging; however, this area is just beginning to evolve, and many issues have not been solved yet. In the future, it is expected that endoscopic molecular imaging will be of increasing interest among clinicians as a new technology for the identification and evaluation of colorectal neoplasm and colitis-associated cancer.

Citations

Citations to this article as recorded by  
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    Kyeong Ok Kim
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    金良 肖
    Advances in Clinical Medicine.2022; 12(12): 11023.     CrossRef
  • Differentiating between Intestinal Tuberculosis and Crohn’s Disease May Be Complicated by Multidrug-resistant Mycobacterium tuberculosis
    Seung Wook Hong, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang
    The Ewha Medical Journal.2021; 44(3): 93.     CrossRef
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    Hyung Il Kim, Jinhyeon Kim, Hyori Kim, Hyeri Lee, Yong Sik Yoon, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Sun Young Kim, Seung-Jae Myung
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    Seong-Eun Kim
    The Ewha Medical Journal.2021; 44(4): 148.     CrossRef
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Original Article
Functional bowel disorders
Evaluation of symptoms and symptom combinations in histamine intolerance
Wolfgang J. Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Sandra J. Holasek, Harald Mangge
Intest Res 2019;17(3):427-433.   Published online March 7, 2019
DOI: https://doi.org/10.5217/ir.2018.00152
AbstractAbstract PDFPubReaderePub
Background/Aims
Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT.
Methods
In an analysis of outpatients’ charts we identified 133 patients, who presented with recurring nonspecific functional gastrointestinal, extraintestinal symptoms, and a diamine oxidase value <10 U/mL, indicative of HIT. A standardized anonymous questionnaire with symptoms of HIT based on known symptoms and the 4 histamine receptors including gastrointestinal, cardiovascular, respiratory and skin complaints was developed, and sent by mail to the patients.
Results
In the 62 patients that completed the questionnaire bloating was the most common and most serious symptom. Other commonly reported gastrointestinal symptoms were postprandial fullness, diarrhea, abdominal pain, and constipation. The presence of 2 from a list of 24 symptoms resulted in 276 various symptom combinations. From calculated 2.024 possible combinations of 3 symptoms the patients with HIT presented 1.975 combinations.
Conclusions
The knowledge of this wide variability of symptoms and complex symptom combinations in patients with HIT may help to clinically recognize and diagnose HIT.

Citations

Citations to this article as recorded by  
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    Wolfgang J. Schnedl, Dietmar Enko
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    Wolfgang J. Schnedl, Harald Mangge, Michael Schenk, Dietmar Enko
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    Wolfgang J. Schnedl, Dietmar Enko
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    Sònia Sánchez-Pérez, Oriol Comas-Basté, M. Teresa Veciana-Nogués, M. Luz Latorre-Moratalla, M. Carmen Vidal-Carou
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    Wojciech Nazar, Katarzyna Plata-Nazar, Katarzyna Sznurkowska, Agnieszka Szlagatys-Sidorkiewicz
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    Domenico Gargano, Ramapraba Appanna, Antonella Santonicola, Fabio De Bartolomeis, Cristiana Stellato, Antonella Cianferoni, Vincenzo Casolaro, Paola Iovino
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    Yulia O. Shulpekova, Vladimir M. Nechaev, Irina R. Popova, Tatiana A. Deeva, Arthur T. Kopylov, Kristina A. Malsagova, Anna L. Kaysheva, Vladimir T. Ivashkin
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    Francesco Giuseppe Galluzzo, Gaetano Cammilleri, Antonello Cicero, Licia Pantano, Andrea Pulvirenti, Andrea Macaluso, Nicola Cicero, Vittorio Calabrese, Vincenzo Ferrantelli
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    Nevio Cimolai
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  • Histamine Intolerance: The Current State of the Art
    Oriol Comas-Basté, Sònia Sánchez-Pérez, Maria Teresa Veciana-Nogués, Mariluz Latorre-Moratalla, María del Carmen Vidal-Carou
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  • Increasing Expiratory Hydrogen in Lactose Intolerance Is Associated with Additional Food Intolerance/Malabsorption
    Wolfgang J. Schnedl, Nathalie Meier-Allard, Sonja Lackner, Dietmar Enko, Harald Mangge, Sandra J. Holasek
    Nutrients.2020; 12(12): 3690.     CrossRef
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    Dóra Solymosi, Miklós Sárdy, Györgyi Pónyai
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  • Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles
    Armelle Tchoumi Neree, Rodolphe Soret, Lucia Marcocci, Paola Pietrangeli, Nicolas Pilon, Mircea Alexandru Mateescu
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  • Diamine oxidase supplementation improves symptoms in patients with histamine intolerance
    Wolfgang J. Schnedl, Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge, Florian Forster
    Food Science and Biotechnology.2019; 28(6): 1779.     CrossRef
  • Food Intolerances
    Caroline J Tuck, Jessica R Biesiekierski, Peter Schmid-Grendelmeier, Daniel Pohl
    Nutrients.2019; 11(7): 1684.     CrossRef
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Review
Pathogenic role of the gut microbiota in gastrointestinal diseases
Hiroko Nagao-Kitamoto, Sho Kitamoto, Peter Kuffa, Nobuhiko Kamada
Intest Res 2016;14(2):127-138.   Published online April 27, 2016
DOI: https://doi.org/10.5217/ir.2016.14.2.127
AbstractAbstract PDFPubReaderePub

The gastrointestinal (GI) tract is colonized by a dense community of commensal microorganisms referred to as the gut microbiota. The gut microbiota and the host have co-evolved, and they engage in a myriad of immunogenic and metabolic interactions. The gut microbiota contributes to the maintenance of host health. However, when healthy microbial structure is perturbed, a condition termed dysbiosis, the altered gut microbiota can trigger the development of various GI diseases including inflammatory bowel disease, colon cancer, celiac disease, and irritable bowel syndrome. There is a growing body of evidence suggesting that multiple intrinsic and extrinsic factors, such as genetic variations, diet, stress, and medication, can dramatically affect the balance of the gut microbiota. Therefore, these factors regulate the development and progression of GI diseases by inducing dysbiosis. Herein, we will review the recent advances in the field, focusing on the mechanisms through which intrinsic and extrinsic factors induce dysbiosis and the role a dysbiotic microbiota plays in the pathogenesis of GI diseases.

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  • Dietary Polyphenols, Food Processing and Gut Microbiome: Recent Findings on Bioavailability, Bioactivity, and Gut Microbiome Interplay
    Monika Sejbuk, Iwona Mirończuk-Chodakowska, Sercan Karav, Anna Maria Witkowska
    Antioxidants.2024; 13(10): 1220.     CrossRef
  • Gastrointestinal pathophysiology in long COVID: Exploring roles of microbiota dysbiosis and serotonin dysregulation in post-infectious bowel symptoms
    Linda Chia-Hui Yu
    Life Sciences.2024; 358: 123153.     CrossRef
  • Fecal microbiota transplantation from postmenopausal osteoporosis human donors accelerated bone mass loss in mice
    Tinglong Chen, Ning Wang, Yongqiang Hao, Lingjie Fu
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Gastrointestinal Tract, Microbiota and Multiple Sclerosis (MS) and the Link Between Gut Microbiota and CNS
    Bahman Yousefi, Ali Babaeizad, Seyedeh Zahra Banihashemian, Zahra Khatibiyan Feyzabadi, Mehdi Dadashpour, Daryoush Pahlevan, Hadi Ghaffari, Majid Eslami
    Current Microbiology.2023;[Epub]     CrossRef
  • Microbiota and Cardiovascular Diseases: Mechanisms of Influence and Correction Possibilities
    A. V. Gorbenko, Y. P. Skirdenko, K. A. Andreev, M. M. Fedorin, N. A. Nikolaev, M. A. Livzan
    Rational Pharmacotherapy in Cardiology.2023; 19(1): 58.     CrossRef
  • Metabolites, gene expression, and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g-ABA contents in Megalobrama amblycephala
    Yizhuo Hua, Wangwang Huang, Fan Wang, Zhao Jing, Juntao Li, Qingchao Wang, Yuhua Zhao
    Fish Physiology and Biochemistry.2023; 49(2): 253.     CrossRef
  • HIV Tat Expression and Cocaine Exposure Lead to Sex- and Age-Specific Changes of the Microbiota Composition in the Gut
    Lu Li, Xiaojie Zhao, Johnny J. He
    Microorganisms.2023; 11(3): 799.     CrossRef
  • In vitro fermentation of epilactose and epilactitol by human faecal microbiota
    Yuwei Zhang, Yu Qiao, Xiaoqing Xu, Qing Peng, Jinwei Ren, Lan Ma, Dandan Tian, Yuxin Gong, Deqin Feng, Bo Shi
    International Dairy Journal.2023; 144: 105697.     CrossRef
  • Growth performance, blood metabolites, ruminal fermentation, and bacterial community in preweaning dairy calves fed corn silage-included starter and total mixed ration
    Jun Zhang, Jiaqi Shang, Yangyi Hao, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li
    Journal of Dairy Science.2023; 106(7): 4545.     CrossRef
  • A short-term bioreactor assay to assess the effect of essential oils on a microbiota derived from piglet’s intestinal content
    Mathieu Bellerose, Philippe Fravalo, Isabelle Mainville, Yves Arcand, Alexandre Thibodeau
    Acta Veterinaria Scandinavica.2023;[Epub]     CrossRef
  • Potential of olive oil and its phenolic compounds as therapeutic intervention against colorectal cancer: a comprehensive review
    Arindam Sain, Sakshi Sahu, Debdut Naskar
    British Journal of Nutrition.2022; 128(7): 1257.     CrossRef
  • State-of-the-Art Clinical Microbiology in South Korea: Current Trends and Future Prospects
    Garima Sharma, Jin-Chul Kim
    Microorganisms.2022; 10(1): 174.     CrossRef
  • Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota
    Qiao Xiang, Lu Cheng, Ruilin Zhang, Yanan Liu, Zufang Wu, Xin Zhang
    Foods.2022; 11(4): 506.     CrossRef
  • Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis?
    Leon M. T. Dicks, Shelly M. Deane, Matthew J. Grobbelaar
    Probiotics and Antimicrobial Proteins.2022; 14(2): 217.     CrossRef
  • A proposal for the reference intervals of the Italian microbiota “scaffold” in healthy adults
    Davide Sisti, Valerio Pazienza, Fabio Piccini, Barbara Citterio, Wally Baffone, Sabrina Donati Zeppa, Francesca Biavasco, Emilia Prospero, Antonio De Luca, Marco Artico, Samanta Taurone, Andrea Minelli, Francesco Perri, Elena Binda, Riccardo Pracella, Ric
    Scientific Reports.2022;[Epub]     CrossRef
  • Gut microbiota in gastrointestinal diseases during pregnancy
    Zhong-Zhen Liu, Jing-Hua Sun, Wen-Jing Wang
    World Journal of Clinical Cases.2022; 10(10): 2976.     CrossRef
  • Simulated elephant colon for cellulose extraction from sugarcane bagasse: An effective pretreatment to reduce chemical use
    Chotiwit Sriwong, Prakit Sukyai
    Science of The Total Environment.2022; 835: 155281.     CrossRef
  • Does Lactobacillus reuteri influence ergothioneine levels in the human body?
    Irwin K. Cheah, Jovan Z. Lee, Richard M. Y. Tang, Pei Wen Koh, Barry Halliwell
    FEBS Letters.2022; 596(10): 1241.     CrossRef
  • Insights into diet-associated oxidative pathomechanisms in inflammatory bowel disease and protective effects of functional amino acids
    Yun Ji, Ying Yang, Shiqiang Sun, Zhaolai Dai, Fazheng Ren, Zhenlong Wu
    Nutrition Reviews.2022; 81(1): 95.     CrossRef
  • Untangling the oral–gut axis in the pathogenesis of intestinal inflammation
    Sho Kitamoto, Nobuhiko Kamada
    International Immunology.2022; 34(9): 485.     CrossRef
  • Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials
    Chien-Tai Hong, Jia-Hung Chen, Tsai-Wei Huang
    Aging.2022; 14(17): 7014.     CrossRef
  • Lactobacillus plantarum BSGP201683 Improves the Intestinal Barrier of Giant Panda Microbiota-Associated Mouse Infected by Enterotoxigenic Escherichia coli K88
    Yi Zhou, Xueqin Ni, Ling Duan, Lili Niu, Qian Liu, Yan Zeng, Qiang Wang, Jie Wang, Abdul Khalique, Kangcheng Pan, Bo Jing, Dong Zeng
    Probiotics and Antimicrobial Proteins.2021; 13(3): 664.     CrossRef
  • Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 −/−) and wild-type (WT) mice
    Darab Ghadimi, Michael de Vrese, Michael Ebsen, Christoph Röcken, Sven Olaf Frahm, Janine Zahlten, Regina Fölster-Holst, Knut J. Heller, Wilhelm Bockelmann
    Immunobiology.2021; 226(1): 152028.     CrossRef
  • Are silver nanoparticles better than triclosan as a daily antimicrobial? Answers from the perspectives of gut microbiome disruption and pathogenicity
    Mingzhu Li, Chengdong Zhang
    Science of The Total Environment.2021; 756: 143983.     CrossRef
  • (Mögliche) Rolle des Mikrobioms in der Diagnostik, Therapie und Genese des Kolonkarzinoms
    Christian Schulz, Alexander Neuner, Christoph A. Jacobi
    Der Onkologe.2021; 27(3): 195.     CrossRef
  • Giardia spp. and the Gut Microbiota: Dangerous Liaisons
    Elena Fekete, Thibault Allain, Affan Siddiq, Olivia Sosnowski, Andre G. Buret
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Astragalin Inhibits Nuclear Factor-κB Signaling in Human Colonic Epithelial Cells and Attenuates Experimental Colitis in Mice
    Yoo Min Han, Jaemoon Koh, Jee Hyun Kim, Jooyoung Lee, Jong Pil Im, Joo Sung Kim
    Gut and Liver.2021; 15(1): 100.     CrossRef
  • Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs)
    Toumi Ryma, Arezki Samer, Imene Soufli, Hayet Rafa, Chafia Touil-Boukoffa
    Gastroenterology Insights.2021; 12(1): 56.     CrossRef
  • Health risk assessment based on metal analysis of soil and crops in Al-Dakhla Oasis
    Hosam M. Saleh, Hazem H. Mahmoud, Mona I. Abdou, Samir B. Eskander
    Arabian Journal of Geosciences.2021;[Epub]     CrossRef
  • Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer
    Yiming Yin, Mengge Wang, Wenjie Gu, Lili Chen
    Biochemical Pharmacology.2021; 186: 114430.     CrossRef
  • The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes
    Carolin Wiechers, Mangge Zou, Eric Galvez, Michael Beckstette, Maria Ebel, Till Strowig, Jochen Huehn, Joern Pezoldt
    Cellular & Molecular Immunology.2021; 18(5): 1211.     CrossRef
  • Gastroprotective Effects of Polyphenols against Various Gastro-Intestinal Disorders: A Mini-Review with Special Focus on Clinical Evidence
    Hui-Fang Chiu, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang
    Molecules.2021; 26(7): 2090.     CrossRef
  • Isolation and genomic characterization of five novel strains of Erysipelotrichaceae from commercial pigs
    Jinyuan Wu, Min Liu, Mengqing Zhou, Lin Wu, Hui Yang, Lusheng Huang, Congying Chen
    BMC Microbiology.2021;[Epub]     CrossRef
  • Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics
    Laura-Berenice Olvera-Rosales, Alma-Elizabeth Cruz-Guerrero, Esther Ramírez-Moreno, Aurora Quintero-Lira, Elizabeth Contreras-López, Judith Jaimez-Ordaz, Araceli Castañeda-Ovando, Javier Añorve-Morga, Zuli-Guadalupe Calderón-Ramos, José Arias-Rico, Luis-G
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  • Septic arthritis caused by Desulfovibrio desulfuricans: A case report and review of the literature
    Timothy J. Marquis, Vincent J. Williams, David B. Banach
    Anaerobe.2021; : 102407.     CrossRef
  • Pathogenetic factors of ulcerative colitis: mainstream for 2020
    G. R. Bicbavova, M. A. Livzan, M. Yu. Lozinskaya
    Bulletin of Siberian Medicine.2021; 20(2): 130.     CrossRef
  • Effect of gut microbiome on minor complications after a colonoscopy
    Jae Hyun Kim, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
    Intestinal Research.2021; 19(3): 341.     CrossRef
  • Gut Microbiota Community Shift with Severity of Coronary Artery Disease
    Jia-Lu Hu, Zhi-Feng Yao, Min-Na Tang, Chun Tang, Xiao-Fan Zhao, Xi Su, Dan-Bo Lu, Qiu-Rong Li, Zhang-Sheng Wang, Yan Yan, Zeneng Wang
    Engineering.2021; 7(12): 1715.     CrossRef
  • Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34
    Wimonrat Panpetch, Pratsanee Hiengrach, Sumanee Nilgate, Somying Tumwasorn, Naraporn Somboonna, Alisa Wilantho, Piraya Chatthanathon, Piyapan Prueksapanich, Asada Leelahavanichkul
    Gut Microbes.2020; 11(3): 465.     CrossRef
  • The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease
    Naren Bao, Fangjie Chen, Di Dai
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Adhesion and anti-inflammatory potential ofLactobacillus rhamnosusGG in a sea buckthorn based beverage matrix
    Srijita Sireswar, Sutapa Biswas, Gargi Dey
    Food & Function.2020; 11(3): 2555.     CrossRef
  • Intestinal epithelial barrier and neuromuscular compartment in health and disease
    Vanessa D’Antongiovanni, Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Corrado Blandizzi, Luca Antonioli, Nunzia Bernardini
    World Journal of Gastroenterology.2020; 26(14): 1564.     CrossRef
  • The impact of acute stress disorder on gallbladder interstitial cells of Cajal
    Zhen‐peng Huang, Hu Qiu, Ke Wang, Wei‐bo Chao, Hao‐bin Zhu, Hang Chen, Yue Liu, Bao‐ping Yu
    Journal of Cellular Physiology.2020; 235(11): 8424.     CrossRef
  • The relationship between the commensal microbiota levels and Crohn's disease activity
    Hagamenon de Alencar Junior, Ana Paula Ribeiro Paiotti, Humberto Bezerra de Araújo Filho, Celina Tizuko Fujiyama Oshima, Sender Jankiel Miszputen, Orlando Ambrogini‐Júnior
    JGH Open.2020; 4(5): 784.     CrossRef
  • Gut microbiota health closely associates with PCB153-derived risk of host diseases
    Lingli Min, Yulang Chi, Sijun Dong
    Ecotoxicology and Environmental Safety.2020; 203: 111041.     CrossRef
  • Comparison of Gut Microbiota Diversity and Predicted Functions Between Healthy and Diseased Captive Rana dybowskii
    Qing Tong, Li-Yong Cui, Xiao-Peng Du, Zong-Fu Hu, Jia Bie, Jian-Hua Xiao, Hong-Bin Wang, Jian-Tao Zhang
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Intestinal microbiocenosis in patients with recurrent Clostridium difficile infection, ulcerative colitis and irritable bowel syndrome after transplantation of fecal microflora
    E. V. Shrainer, A. I. Khavkin, V. V. Vlasov
    Experimental and Clinical Gastroenterology.2020; (7): 69.     CrossRef
  • Detection of Streptococcus gallolyticus in colorectal cancer and inflammatory bowel disease patients compared to control group in southwest of Iran
    Ahmad Farajzadeh Sheikh, Abdol Rahim Masjedi Zadeh, Morteza Saki, Parisa Khani, Seyed Jalal Hashemi, Sam Shahin Zadeh, Maryam Dastoorpoor
    Molecular Biology Reports.2020; 47(11): 8361.     CrossRef
  • An analysis of gut dysbiosis in obesity, diabetes, and chronic gut conditions
    Ahmed Haleem, Sama Anvari, Aisha Nazli, Mohamed Sager, Mahmood Akhtar
    Ibnosina Journal of Medicine and Biomedical Sciences.2020; 12(04): 264.     CrossRef
  • Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19
    Taha Baghbani, Hossein Nikzad, Javid Azadbakht, Fatemeh Izadpanah, Hamed Haddad Kashani
    Microbial Cell Factories.2020;[Epub]     CrossRef
  • Fecal Microbiota of Toxigenic Clostridioides difficile-Associated Diarrhea
    Marta Hernández, Mónica de Frutos, David Rodríguez-Lázaro, Luis López-Urrutia, Narciso M. Quijada, Jose María Eiros
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Hsp60 as a Novel Target in IBD Management: A Prospect
    Francesco Cappello, Margherita Mazzola, Abdo Jurjus, Marie-Noel Zeenny, Rosalyn Jurjus, Francesco Carini, Angelo Leone, Giuseppe Bonaventura, Giovanni Tomasello, Fabio Bucchieri, Everly Conway de Macario, Alberto J. L. Macario
    Frontiers in Pharmacology.2019;[Epub]     CrossRef
  • Intestinibaculum porci gen. nov., sp. nov., a new member of the family Erysipelotrichaceae isolated from the small intestine of a swine
    Ji-Sun Kim, Hanna Choe, Yu-Ri Lee, Kyung Mo Kim, Doo-Sang Park
    Journal of Microbiology.2019; 57(5): 381.     CrossRef
  • Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide, Population-Based Study
    Kookhwan Choi, Jaeyoung Chun, Kyungdo Han, Seona Park, Hosim Soh, Jihye Kim, Jooyoung Lee, Hyun Lee, Jong Im, Joo Kim
    Journal of Clinical Medicine.2019; 8(5): 654.     CrossRef
  • Novel Selective Estrogen Receptor Modulator Ameliorates Murine Colitis
    Lauri Polari, Santeri Anttila, Terhi Helenius, Anu Wiklund, Tero Linnanen, Diana M. Toivola, Jorma Määttä
    International Journal of Molecular Sciences.2019; 20(12): 3007.     CrossRef
  • Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes?
    Chiara Pellicano, Giorgia Leodori, Giuseppe Pietro Innocenti, Antonietta Gigante, Edoardo Rosato
    Nutrients.2019; 11(11): 2629.     CrossRef
  • Impact of microbiota in colorectal carcinogenesis: lessons from experimental models
    Linda Chia-Hui Yu, Shu-Chen Wei, Yen-Hsuan Ni
    Intestinal Research.2018; 16(3): 346.     CrossRef
  • Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis
    Carlos A Rubio, Cord Langner, Peter T Schmidt
    Histopathology.2018; 72(4): 580.     CrossRef
  • Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer
    Veronica Lazar, Lia-Mara Ditu, Gratiela Gradisteanu Pircalabioru, Irina Gheorghe, Carmen Curutiu, Alina Maria Holban, Ariana Picu, Laura Petcu, Mariana Carmen Chifiriuc
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • How to improve the gluten-free diet: The state of the art from a food science perspective
    Marco Gobbetti, Erica Pontonio, Pasquale Filannino, Carlo Giuseppe Rizzello, Maria De Angelis, Raffaella Di Cagno
    Food Research International.2018; 110: 22.     CrossRef
  • Irritable Bowel-like Symptoms in Ulcerative Colitis are as Common in Patients in Deep Remission as in Inflammation: Results From a Population-based Study [the IBSEN Study]
    Magne Henriksen, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Bjørn Moum
    Journal of Crohn's and Colitis.2018; 12(4): 389.     CrossRef
  • Trace Element and Heavy Metal Levels in Colorectal Cancer: Comparison Between Cancerous and Non-cancerous Tissues
    Masoudreza Sohrabi, Ali Gholami, MohammadHossein Hosseini Azar, Mohammad Yaghoobi, Maryamosadat Mirasgari Shahi, Solmaz Shirmardi, Mehdi Nikkhah, Zahra Kohi, Delaram Salehpour, Mahmood Reza Khoonsari, Gholamrez Hemmasi, Farhad Zamani, Mahmoudreza Sohrabi,
    Biological Trace Element Research.2018; 183(1): 1.     CrossRef
  • Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats
    Sehyung Pak, Sung Wook Hwang, In Kyong Shim, Sang Mun Bae, Yeon- Mi Ryu, Han-Byul Kim, Eun-ju Do, Hye-Nam Son, Eun-ji Choi, Sun-ha Park, Sang-Yeob Kim, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Nobuo Kanai, Masanori Maeda, Teruo Okano, Dong-Hoon Yang
    Scientific Reports.2018;[Epub]     CrossRef
  • Advances in Probiotic Regulation of Bone and Mineral Metabolism
    Laura R. McCabe, Narayanan Parameswaran
    Calcified Tissue International.2018; 102(4): 480.     CrossRef
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    Giorgia Mori, Simone Rampelli, Beatrice Silvia Orena, Claudia Rengucci, Giulia De Maio, Giulia Barbieri, Alessandro Passardi, Andrea Casadei Gardini, Giovanni Luca Frassineti, Stefano Gaiarsa, Alessandra M. Albertini, Guglielmina Nadia Ranzani, Daniele Ca
    Scientific Reports.2018;[Epub]     CrossRef
  • An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer
    Mohammed Faruk, Sani Ibrahim, Ahmed Adamu, Abdulmumini Hassan Rafindadi, Yahaya Ukwenya, Yawale Iliyasu, Abdullahi Adamu, Surajo Mohammed Aminu, Mohammed Sani Shehu, Danladi Amodu Ameh, Abdullahi Mohammed, Saad Aliyu Ahmed, John Idoko, Atara Ntekim, Aisha
    Intestinal Research.2018; 16(1): 99.     CrossRef
  • Disparate effects of antibiotics on hypertension
    S. Galla, S. Chakraborty, X. Cheng, J. Yeo, B. Mell, H. Zhang, A. V. Mathew, M. Vijay-Kumar, B. Joe
    Physiological Genomics.2018; 50(10): 837.     CrossRef
  • The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview
    Amosy E. M’Koma
    Gastrointestinal Disorders.2018; 1(1): 75.     CrossRef
  • Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease
    Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, Taku Kobayashi, Masahide Oshita, Hiroki Tanaka, Keiji Ozeki, Sakuma Takahashi, Hiroki Kitamoto, Kazuhito Kani, Sohachi Nanjo, Takeshi Sugaya, Yuko Sakakibara, Toshihiro Inokuchi, Kazuki Ka
    Intestinal Research.2018; 16(4): 609.     CrossRef
  • Microbiome, gut dysbiosis and inflammatory bowel disease: That moment when the function is more important than taxonomy
    S. I. Sitkin, T. Ya. Vakhitov, E. V. Demyanova
    Almanac of Clinical Medicine.2018; 46(5): 396.     CrossRef
  • Association of Perianal Fistulas with Clinical Features and Prognosis of Crohn's Disease in Korea: Results from the CONNECT Study
    Jaeyoung Chun, Jong Pil Im, Ji Won Kim, Kook Lae Lee, Chang Hwan Choi, Hyunsoo Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, You Sun Kim, Yoon Tae Jeen, Dong Soo Han, Won Ho Kim, Joo Sung Kim
    Gut and Liver.2018; 12(5): 544.     CrossRef
  • Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients
    Shinta Mizuno, Kosaku Nanki, Katsuyoshi Matsuoka, Keiichiro Saigusa, Keiko Ono, Mari Arai, Shinya Sugimoto, Hiroki Kiyohara, Moeko Nakashima, Kozue Takeshita, Makoto Naganuma, Wataru Suda, Masahira Hattori, Takanori Kanai
    Intestinal Research.2017; 15(1): 68.     CrossRef
  • Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders
    Uday C. Ghoshal, Ujjala Ghoshal
    Gastroenterology Clinics of North America.2017; 46(1): 103.     CrossRef
  • Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice
    Lien Van den Bossche, Pieter Hindryckx, Lindsey Devisscher, Sarah Devriese, Sophie Van Welden, Tom Holvoet, Ramiro Vilchez-Vargas, Marius Vital, Dietmar H. Pieper, Julie Vanden Bussche, Lynn Vanhaecke, Tom Van de Wiele, Martine De Vos, Debby Laukens, Chri
    Applied and Environmental Microbiology.2017;[Epub]     CrossRef
  • Host-microbial Cross-talk in Inflammatory Bowel Disease
    Hiroko Nagao-Kitamoto, Nobuhiko Kamada
    Immune Network.2017; 17(1): 1.     CrossRef
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    Gretchen Irwin, Laura Mayans, Rick Kellerman
    Primary Care: Clinics in Office Practice.2017; 44(4): 733.     CrossRef
  • Selected Probiotic Lactobacilli Have the Capacity To Hydrolyze Gluten Peptides during Simulated Gastrointestinal Digestion
    Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti, Johanna Björkroth
    Applied and Environmental Microbiology.2017;[Epub]     CrossRef
  • Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders
    Soo-Kyung Lim, Seung Jin Yoo, Dae Lim Koo, Chae A Park, Han Jun Ryu, Yong Jin Jung, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Seong-Joon Koh
    World Journal of Gastroenterology.2017; 23(18): 3330.     CrossRef
  • Microbiotal-Host Interactions and Hypertension
    Sarah Galla, Saroj Chakraborty, Blair Mell, Matam Vijay-Kumar, Bina Joe
    Physiology.2017; 32(3): 224.     CrossRef
  • Effect of gut microbiota on host whole metabolome
    Takeo Moriya, Yoshinori Satomi, Shumpei Murata, Hiroshi Sawada, Hiroyuki Kobayashi
    Metabolomics.2017;[Epub]     CrossRef
  • The gastrointestinal microbiota and its role in oncogenesis
    S.Y. Lam, J. Yu, S.H. Wong, M.P. Peppelenbosch, G.M. Fuhler
    Best Practice & Research Clinical Gastroenterology.2017; 31(6): 607.     CrossRef
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    Inés Mármol, Cristina Sánchez-de-Diego, Alberto Pradilla Dieste, Elena Cerrada, María Rodriguez Yoldi
    International Journal of Molecular Sciences.2017; 18(1): 197.     CrossRef
  • Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies
    Duk Hwan Kim, Jae Hee Cheon
    Immune Network.2017; 17(1): 25.     CrossRef
  • Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
    T Kim, C L Holleman, T Ptacek, C D Morrow, K M Habegger
    International Journal of Obesity.2017; 41(3): 381.     CrossRef
  • NF-kappa B activation correlates with disease phenotype in Crohn’s disease
    Yoo Min Han, Jaemoon Koh, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Gernot Sellge
    PLOS ONE.2017; 12(7): e0182071.     CrossRef
  • Microbial approaches for targeting antibiotic‐resistant bacteria
    Wing Fei Wong, Marina Santiago
    Microbial Biotechnology.2017; 10(5): 1047.     CrossRef
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    Anamaria Girbovan, Genel Sur, Gabriel Samasca, Iulia Lupan
    Medical Microbiology and Immunology.2017; 206(2): 83.     CrossRef
  • Nanosized Drug Delivery Systems in Gastrointestinal Targeting: Interactions with Microbiota
    Michail Karavolos, Alina Holban
    Pharmaceuticals.2016; 9(4): 62.     CrossRef
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