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Original Articles
Colorectal neoplasia
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer
In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee
Intest Res 2019;17(3):404-412.   Published online November 12, 2018
DOI: https://doi.org/10.5217/ir.2018.00072
AbstractAbstract PDFPubReaderePub
Background/Aims
To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.
Methods
Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.
Results
The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm2 , respectively (P<0.001). The risk of adenoma positively correlated with VAT area and the visceral-to-total fat ratio (P for trend <0.01), but the risk of CRC did not (P>0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018)
Conclusions
VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.

Citations

Citations to this article as recorded by  
  • The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis
    Iman Elahi Vahed, Mahsa Moshgelgosha, Abdolmajid Kor, Mona Minadi, Faezeh Ebrahimi, Aylar Azhdarian, Mobina Arjmandi, Aida Alamdar, Maede Zare, Niloufar Shabani, Hossein Soltaninejad, Mohammad Rahmanian
    BMC Cancer.2025;[Epub]     CrossRef
  • Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
    Younes Kays Mohammed Ali, Troels Gammeltoft Dolin, Janus Damm Nybing, Jakob Lykke, Frederik Hvid Linden, Erik Høgh-Schmidt, Thorkild I. A. Sørensen, Jesper Frank Christensen, Yousef J. W. Nielsen, Jim Stenfatt Larsen, Sten Madsbad, Julia Sidenius Johansen
    International Journal of Obesity.2024; 48(4): 533.     CrossRef
  • Research Progress on the Correlation between Metabolic Syndrome and Colorectal Polyps
    欣然 王
    Advances in Clinical Medicine.2024; 14(03): 1733.     CrossRef
  • MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
    Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo, Hong Xu
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
    Jung Ho Lee, Hyunseok Cho, Sang Hoon Lee, Sung Joon Lee, Chang Don Kang, Dae Hee Choi, Jin Myung Park, Seung-Joo Nam, Tae Suk Kim, Ji Hyun Kim, Sung Chul Park
    The Korean Journal of Gastroenterology.2024; 83(4): 143.     CrossRef
  • Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis
    Le Gao, Tian Yang, Ziru Xue, Chak Kwan Dickson Chan
    Life.2023; 13(2): 337.     CrossRef
  • Abdominal fat and muscle distributions in different stages of colorectal cancer
    Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
    BMC Cancer.2023;[Epub]     CrossRef
  • Arterial stiffness is associated with high-risk colorectal adenomas and serrated lesions: A cross-sectional study in a Taiwanese population
    Hung-Yu Chen, Wen-Huang Lee, Hung-Lung Hsu, Yu-Tsung Chou, Fei-Lin Su, I-Hsuan Wu, Ting-Hsing Chao
    Journal of Cardiology.2022; 80(2): 139.     CrossRef
  • Relationship between BMI, CT-derived body composition and colorectal neoplasia in a bowel screening population
    Domenic G. Di Rollo, Josh McGovern, Christopher Morton, Gillian Miller, Ross Dolan, Paul G. Horgan, Donald C. McMillan, David Mansouri
    Scottish Medical Journal.2022; 67(3): 93.     CrossRef
  • Review article: obesity and colorectal cancer
    Marc Bardou, Alexia Rouland, Myriam Martel, Romaric Loffroy, Alan N. Barkun, Nicolas Chapelle
    Alimentary Pharmacology & Therapeutics.2022; 56(3): 407.     CrossRef
  • The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods
    Xingyu Jiang, Qi Liang, Huanhuan Xu, Shouyong Gu, Lingxiang Liu, Jincheng Wang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Obesity Is Not an Independent Predictor of Necrotizing Soft Tissue Infection Outcomes
    Hannah Zhao-Fleming, Mhd Hasan Almekdash, Elizabeth Cook, Armand Northcut, Diana Mitchell, Kendra Rumbaugh, Sharmila Dissanaike
    Surgical Infections.2021; 22(2): 187.     CrossRef
  • Optimization of the surveillance strategy in patients with colorectal adenomas: A combination of clinical parameters and index colonoscopy findings
    Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Journal of Gastroenterology and Hepatology.2021; 36(4): 974.     CrossRef
  • Obesity, sleep apnea, and cancer
    Isaac Almendros, Miguel A. Martinez-Garcia, Ramon Farré, David Gozal
    International Journal of Obesity.2020; 44(8): 1653.     CrossRef
  • Opportunistic use of radiological measures of visceral adiposity for assessment of risk of colorectal adenoma
    Zi Qin Ng, Ruwan Wijesuriya, Philip Misur, Jih Huei Tan, Kyaw Soe Moe, Mary Theophilus
    ANZ Journal of Surgery.2020; 90(11): 2298.     CrossRef
  • Changes in Abdominal Obesity Affect the Risk of Metachronous Advanced Colorectal Neoplasia Development after Polypectomy
    Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Yonsei Medical Journal.2020; 61(7): 579.     CrossRef
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  • 16 Web of Science
  • 16 Crossref
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Visceral Fat as a Useful Parameter in the Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis
Jun Kwon Ko, Hang Lak Lee, Jin Ok Kim, Soon Young Song, Kang Nyeong Lee, Dae Won Jun, Oh Young Lee, Dong Soo Han, Byung Chul Yoon, Ho Soon Choi, Joon Soo Hahm, Sang-Yeon Kim
Intest Res 2014;12(1):42-47.   Published online January 28, 2014
DOI: https://doi.org/10.5217/ir.2014.12.1.42
AbstractAbstract PDFPubReader
<b>Background/Aims</b><br/>

Because of the similarities in the clinical presentations of Crohn's disease (CD) and intestinal tuberculosis (ITB), differential diagnosis is critical. Mesenteric adipose tissue hypertrophy and creeping fat are characteristic features of CD. The purpose of this study was to assess the usefulness of visceral fat for the differential diagnosis of CD and ITB.

Methods

We conducted a retrospective review of 50 patients with findings of CD or ITB between January 2005 and July 2008. Abdominal computed tomography (CT) was performed on all subjects during their first evaluation. The abdominal fat area was assessed using quantitative abdominal CT.

Results

The ratio of visceral fat to total fat (VF/TF) was significantly higher in male CD patients than in male ITB patients. The ratio of visceral fat to subcutaneous fat (VF/SF) was also higher in CD patients than in patients with ITB. For a VF/TF cut-off value of 0.46, the sensitivity and specificity for the diagnosis of CD were 42.1% and 93.3% respectively, with positive and negative predictive values of 88.9% and 56.0%, respectively.

Conclusion

Measurement of the abdominal fat area using CT can be clinically useful for the differential diagnosis of CD and ITB.

Citations

Citations to this article as recorded by  
  • Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports
    Gang Huang, Kang-Kang Wu, Xiao-Na Li, Jing-Hua Kuai, Ai-Jun Zhang
    World Journal of Gastrointestinal Surgery.2024; 16(1): 248.     CrossRef
  • Enhancing radiologist's detection: an imaging-based grading system for differentiating Crohn's disease from ulcerative colitis
    Ziman Xiong, Yan Zhang, Peili Wu, Jun Chen, Yaqi Shen, Ihab Kamel, Xianying Zheng, Bing Wu, Zhen Li
    BMC Medicine.2024;[Epub]     CrossRef
  • Digestive Tract Tuberculosis Guideline
    Mohamed Tahiri, Khean-Lee Goh, Zaigham Abbas, David Epstein, Chen Min-Hu, Chris J.J. Mulder, Amarender Singh Puri, Michael Schultz, Anton LeMair, Jim Melberg
    Journal of Clinical Gastroenterology.2023; 57(7): 643.     CrossRef
  • Visceral Fat Indices: Do They Help Differentiate Crohn’s Disease and Intestinal Tuberculosis in Children?
    Jayendra Seetharaman, Anshu Srivastava, Rajanikant R Yadav, Sumit K Singh, Prabhakar Mishra, Moinak Sen Sarma, Ujjal Poddar
    Journal of Crohn's and Colitis.2023; 17(12): 2026.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis
    Vishal Sharma
    Expert Review of Gastroenterology & Hepatology.2020; 14(8): 647.     CrossRef
  • Differentiating Crohn’s disease from intestinal tuberculosis
    Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja
    World Journal of Gastroenterology.2019; 25(4): 418.     CrossRef
  • The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10–/– Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis
    Lugen Zuo, Sitang Ge, Yuanyuan Ge, Jingjing Li, Bing Zhu, Zongbing Zhang, Congqiao Jiang, Jing Li, Suanhu Wang, Mulin Liu, Shiqing Li, Rong Wu, Jianguo Hu
    Journal of Crohn's and Colitis.2019; 13(7): 931.     CrossRef
  • Indian guidelines on imaging of the small intestine in Crohn’s disease: A joint Indian Society of Gastroenterology and Indian Radiology and Imaging Association consensus statement
    Saurabh Kedia, Raju Sharma, Govind Makharia, Vineet Ahuja, Devendra Desai, Devasenathipathy Kandasamy, Anu Eapen, Karthik Ganesan, Uday C Ghosha, Naveen Kalra, R Karthikeyan, Kumble Seetharama Madhusudhan, Mathew Philip, Amarender Puri, Sunil Puri, Saroj
    Indian Journal of Radiology and Imaging.2019; 29(02): 111.     CrossRef
  • Serum proteome profiles to differentiate Crohn disease from intestinal tuberculosis and primary intestinal lymphoma
    Longgui Ning, Guodong Shan, Zeyu Sun, Xinhe Lou, Fenming Zhang, Sha Li, Haojie Du, Jinghua Yu, Hongtan Chen, Guoqiang Xu
    Medicine.2019; 98(50): e18304.     CrossRef
  • Creeping fat in patients with ileo‐colonic Crohn's disease correlates with disease activity and severity of inflammation: A preliminary study using energy spectral computed tomography
    Qi Feng, Xi Tao Xu, Yi Zhou, Yun Qi Yan, Zhi Hua Ran, Jiong Zhu
    Journal of Digestive Diseases.2018; 19(8): 475.     CrossRef
  • Making a Positive Diagnosis of Intestinal Tuberculosis with the Aid of New Biologic and Histologic Features: How Far Have We Reached?
    Vatsal Mehta, Devendra Desai, Philip Abraham, Camilla Rodrigues
    Inflammatory Intestinal Diseases.2018; 3(4): 155.     CrossRef
  • Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis
    Saurabh Kedia, Raju Sharma, Vishnubhatla Sreenivas, Kumble Seetharama Madhusudhan, Vishal Sharma, Sawan Bopanna, Venigalla Pratap Mouli, Rajan Dhingra, Dawesh Prakash Yadav, Govind Makharia, Vineet Ahuja
    Intestinal Research.2017; 15(2): 149.     CrossRef
  • Development and validation of visceral fat quantification as a surrogate marker for differentiation of Crohn's disease and intestinal tuberculosis
    Dawesh Prakash Yadav, Kumble Seetharama Madhusudhan, Saurabh Kedia, Raju Sharma, Venigalla Pratap Mouli, Sawan Bopanna, Rajan Dhingra, Rajesh Pradhan, Sandeep Goyal, Vishnubhatla Sreenivas, Naval K Vikram, Govind Makharia, Vineet Ahuja
    Journal of Gastroenterology and Hepatology.2017; 32(2): 420.     CrossRef
  • Imaging of the small intestine in Crohn’s disease: Joint position statement of the Indian Society of Gastroenterology and Indian Radiological and Imaging Association
    Saurabh Kedia, Raju Sharma, Govind K. Makharia, Vineet Ahuja, Devendra Desai, Devasenathipathy Kandasamy, Anu Eapen, Karthik Ganesan, Uday C. Ghoshal, Naveen Kalra, D. Karthikeyan, Kumble Seetharama Madhusudhan, Mathew Philip, Amarender Singh Puri, Sunil
    Indian Journal of Gastroenterology.2017; 36(6): 487.     CrossRef
  • Intestinal tuberculosis and Crohn's disease: challenging differential diagnosis
    Jia Yi Ma, Jin Lu Tong, Zhi Hua Ran
    Journal of Digestive Diseases.2016; 17(3): 155.     CrossRef
  • Change in the diagnosis of inflammatory bowel disease: a hospital-based cohort study from Korea
    Ho-Su Lee, Jaewon Choe, Hyo Jeong Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Yong Sik Yoon, Chang Sik Yu, Jin-Ho Kim, Suk-Kyun Yang
    Intestinal Research.2016; 14(3): 258.     CrossRef
  • 6,263 View
  • 61 Download
  • 17 Web of Science
  • 17 Crossref
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