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Magnetic resonance enterography predicts the prognosis of Crohn's disease
Ji Hoon Lee, Yong Eun Park, Nieun Seo, Hyun Jung Lee, Soo Jung Park, Tae Il Kim, Won Ho Kim, Joon Seok Lim, Jae Hee Cheon
Intest Res 2018;16(3):445-457.   Published online July 27, 2018
DOI: https://doi.org/10.5217/ir.2018.16.3.445
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Magnetic resonance enterography (MRE) has emerged as an important tool in the diagnosis and follow-up of Crohn's disease (CD). The aim of this study was to evaluate whether MRE findings could predict the prognosis of CD.

Methods

In this retrospective study, a total of 173 patients with clinical remission of CD (n=61) or active CD (n=112) were identified. The outcomes of clinical relapse, admission, surgery, and need for other medications according to the MRE findings were evaluated.

Results

The presence of active inflammation on MRE was observed in 93 (83%) patients with clinically active CD and in 44 (72.1%) patients with clinical remission of CD, without a statistically significant difference (P=0.091). In multivariate analysis, active inflammation on MRE increased the risk for clinical relapse (hazard ratio [HR], 6.985; 95% confidence interval [CI], 1.024–47.649) in patients with clinical remission of CD. In patients with clinically active CD, active inflammation on MRE increased the risk for CD-related hospitalization (HR, 2.970; 95% CI, 1.006–8.772).

Conclusions

The presence of active inflammation on MRE was significantly associated with poor prognosis both in patients with clinical remission of CD and in those with active CD.

Citations

Citations to this article as recorded by  
  • Improved IVIM Imaging in Adolescent Crohn's Disease Using Dual‐Echo EPI Distortion and Motion Correction
    Cemre Ariyurek, Lina Lu, Georgios Antonios Sideris, Valentina Valencia Ferrer, Liam Timms, Serge Didenko Vasylechko, Onur Afacan, Sila Kurugol
    NMR in Biomedicine.2025;[Epub]     CrossRef
  • Magnetic resonance enterography for predicting poor prognosis in Crohn’s disease: a systematic review with meta-analysis
    Yizhe Tie, Daiyue Wang, Zinan Fan, Li Li, Minhu Chen, Rirong Chen, Shenghong Zhang
    Therapeutic Advances in Gastroenterology.2025;[Epub]     CrossRef
  • Prognostic Value of Enterography Findings in Crohn’s Disease: A Systematic Review and Meta-Analysis
    Felipe Montevechi-Luz, Adrieli Heloísa Campardo Pansani, Juliana Delgado Campos Mello, Ana Emilia Carvalho de Paula, Lívia Moreira Genaro, Marcia Carolina Mazzaro, Daniel Lahan-Martins, Raquel Franco Leal
    Journal of Imaging.2025; 11(11): 392.     CrossRef
  • The Spectrum of Magnetic Resonance Enterography Findings and the Role of Diffusion-Weighted Imaging in Patients with Active Crohn’s Disease
    Arvin Arian, Ghazal Roostaei, Seyede Sahel Rasoulighasemlouei, Foroogh Alborzi Avanaki, Nasser Ebrahimi Daryani
    Middle East Journal of Digestive Diseases.2024; 16(1): 23.     CrossRef
  • Distribution of small bowel involvement and its association with clinical outcomes in patients with Crohn’s disease
    Jin Park, Hae Young Kim, Yoon Jin Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
    Medicine.2023; 102(40): e35040.     CrossRef
  • Combined Endoscopic and Radiologic Healing Is Associated With a Better Prognosis Than Endoscopic Healing Only in Patients With Crohn's Disease Receiving Anti-TNF Therapy
    Kyunghwan Oh, Eun Hye Oh, Soo Min Noh, Seong Ho Park, Nayoung Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Clinical and Translational Gastroenterology.2022; 13(1): e00442.     CrossRef
  • MR Enterography in Crohnʼs Disease: Comparison of Contrast Imaging with Diffusion-weighted Imaging and a special Form of Color Coding
    Maja Jakob, Maik Backes, Christian Schaefer, Joerg Albert, Angela Geissler
    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.2022; 194(10): 1119.     CrossRef
  • Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
    Giuseppe Cicero, Silvio Mazziotti
    Intestinal Research.2021; 19(4): 365.     CrossRef
  • Radiological Response Is Associated with Better Outcomes and Should Be Considered a Therapeutic Target in Crohn’s Disease
    Eléonore Hallé, Mustapha Azahaf, Nicolas Duveau, Thomas Lambin, Maria Nachury, Julien Branche, Romain Gérard, Clémentine Lauriot Dit Prevost, Pauline Wils, Pierre Desreumaux, Olivier Ernst, Benjamin Pariente
    Digestive Diseases and Sciences.2020; 65(9): 2664.     CrossRef
  • Magnetic Resonance Enterography and Capsule Endoscopy in Patients Undergoing Patency Capsule for the Evaluation of Small Bowel Crohn’s Disease: A Korean Clinical Experience
    Hyun Seok Lee, Yun Jeong Lim, Jin-Hee Jung, Ji Hyung Nam, Junseok Park, Sun Hyung Kang, Ki Bae Kim, Hoon Jai Chun
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Beyond Crohn Disease
    Michael S. Furman, Edward Y. Lee
    Radiologic Clinics of North America.2020; 58(3): 517.     CrossRef
  • Mucosal healing in Crohn’s disease: new insights
    Salvatore Cucchiara, Giulia D’Arcangelo, Sara Isoldi, Marina Aloi, Laura Stronati
    Expert Review of Gastroenterology & Hepatology.2020; 14(5): 335.     CrossRef
  • Changes in the Management of Patients with Crohn’s Disease Based on Magnetic Resonance Enterography Patterns
    Evelyn Sayuri S. Chinem, Barbara C. Esberard, Andre da L. Moreira, Tatiana G. Barbassa, Guilherme M. da Cunha, Antonio Jose de V. Carneiro, Heitor S. de Souza, Ana Teresa P. Carvalho
    Gastroenterology Research and Practice.2019; 2019: 1.     CrossRef
  • 9,422 View
  • 107 Download
  • 12 Web of Science
  • 13 Crossref
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Review
Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease
Kazuo Ohtsuka, Kento Takenaka, Yoshio Kitazume, Toshimitsu Fujii, Katsuyoshi Matsuoka, Maiko Kimura, Takashi Nagaishi, Mamoru Watanabe
Intest Res 2016;14(2):120-126.   Published online April 27, 2016
DOI: https://doi.org/10.5217/ir.2016.14.2.120
AbstractAbstract PDFPubReaderePub

For the control of Crohn's disease (CD) a thorough assessment of the small intestine is essential; several modalities may be utilized, with cross-sectional imaging being important. Magnetic resonance (MR) enterography, i.e., MRE is recommended as a modality with the highest accuracy for CD lesions. MRE and MR enteroclysis are the two methods performed following distension of the small intestine. MRE has sensitivity and specificity comparable to computed tomography enterography (CTE); although images obtained using MRE are less clear compared with CTE, MRE does not expose the patient to radiation and is superior for soft-tissue contrast. Furthermore, it can assess not only static but also dynamic and functional imaging and reveals signs of CD, such as abscess, comb sign, fat edema, fistula, lymph node enhancement, less motility, mucosal lesions, stricture, and wall enhancement. Several indices of inflammatory changes and intestinal damage have been proposed for objective evaluation. Recently, diffusion-weighted imaging has been proposed, which does not need bowel preparation and contrast enhancement. Comprehension of the characteristics of MRE and other modalities is important for better management of CD.

Citations

Citations to this article as recorded by  
  • MR Enterography
    Harsha K. Garg, Kumar K. Shashi, Jessica Kurian, Abbey J. Winant, Edward Y. Lee
    Radiologic Clinics of North America.2025; 63(5): 781.     CrossRef
  • CROHN’S DISEASE: CURRENT INSIGHTS INTO PATHOGENESIS, DIAGNOSIS AND TREATMENT
    Weronika Radecka, Aleksandra Grygorowicz, Klaudia Baran, Michał Ględa, Michał Szyszka, Weronika Kozak, Agnieszka Szreiber, Karol Grela, Karolina Nowacka, Kamil Jabłoński, Anna Woźniak
    International Journal of Innovative Technologies in Social Science.2025;[Epub]     CrossRef
  • Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn’s Disease: Comparison with Balloon-assisted Enteroscopy Findings
    Yoshio Kitazume, Kento Takenaka, Kazuo Ohtsuka, Yasuo Ozawa, Koichiro Kimura, Ryosuke Watanabe, Junichi Tsuchiya, Toshimitsu Fujii, Masakazu Nagahori, Mamoru Watanabe, Ukihide Tateishi
    Magnetic Resonance in Medical Sciences.2023; 22(3): 325.     CrossRef
  • Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
    Giuseppe Cicero, Silvio Mazziotti
    Intestinal Research.2021; 19(4): 365.     CrossRef
  • Magnetic Resonance Enterography and Capsule Endoscopy in Patients Undergoing Patency Capsule for the Evaluation of Small Bowel Crohn’s Disease: A Korean Clinical Experience
    Hyun Seok Lee, Yun Jeong Lim, Jin-Hee Jung, Ji Hyung Nam, Junseok Park, Sun Hyung Kang, Ki Bae Kim, Hoon Jai Chun
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn’s Disease: A Propensity Score-Matched Study
    Kaoru Takabayashi, Naoki Hosoe, Motohiko Kato, Yukie Hayashi, Ryoichi Miyanaga, Kosaku Nanki, Kayoko Fukuhara, Yohei Mikami, Shinta Mizuno, Tomohisa Sujino, Makoto Mutaguchi, Makoto Naganuma, Naohisa Yahagi, Haruhiko Ogata, Takanori Kanai
    Gut and Liver.2020; 14(5): 619.     CrossRef
  • High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease
    Yoshio Kitazume, Junichi Tsuchiya, Kento Takenaka, Kazuo Ohtsuka, Koichiro Kimura, Ryosuke Watanabe, Tomoyuki Fujioka, Toshimitsu Fujii, Mamoru Watanabe, Ukihide Tateisi
    European Journal of Radiology.2020; 133: 109362.     CrossRef
  • The role of small bowel endoscopy for Crohn's disease
    Stefania Chetcuti Zammit, Pierre Ellul, Reena Sidhu
    Current Opinion in Gastroenterology.2019; 35(3): 223.     CrossRef
  • Magnetic resonance enterography predicts the prognosis of Crohn's disease
    Ji Hoon Lee, Yong Eun Park, Nieun Seo, Hyun Jung Lee, Soo Jung Park, Tae Il Kim, Won Ho Kim, Joon Seok Lim, Jae Hee Cheon
    Intestinal Research.2018; 16(3): 445.     CrossRef
  • Quality Indicators for Small Bowel Capsule Endoscopy
    Ki-Nam Shim, Seong Ran Jeon, Hyun Joo Jang, Jinsu Kim, Yun Jeong Lim, Kyeong Ok Kim, Hyun Joo Song, Hyun Seok Lee, Jae Jun Park, Ji Hyun Kim, Jaeyoung Chun, Soo Jung Park, Dong-Hoon Yang, Yang Won Min, Bora Keum, Bo-In Lee
    Clinical Endoscopy.2017; 50(2): 148.     CrossRef
  • 11,690 View
  • 85 Download
  • 15 Web of Science
  • 10 Crossref
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