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Original Article
- Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis
- Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Masamichi Kimura, Yorimitsu Koshikawa, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Hiroshi Nakase
- Intest Res 2015;13(3):250-258. Published online June 9, 2015
- DOI: https://doi.org/10.5217/ir.2015.13.3.250
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Abstract
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Supplementary Material
PubReader <b>Background/Aims</b><br/> The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine in UC patients.
Methods This was a retrospective observational cohort analysis conducted at a single center. Between December 1998 and August 2013, 59 of 87 patients with bio-naive UC who achieved remission after induction with treatments other than biologics were enrolled. Remission maintenance with thiopurine was defined as no concomitant treatment needed other than 5-aminosalicylate without relapse. We assessed the remission-maintenance rate, mucosal healing rate, colectomy-free rate, and treatment safety in UC patients who received thiopurine as maintenance treatment.
Results The 84-month cumulative remission-maintenance and colectomy-free survival rates in the UC patients who were receiving maintenance treatment with thiopurine and 5-aminosalicylate were 43.9% and 88.0%, respectively. Of the 38 patients who underwent colonoscopy during thiopurine maintenance treatment, 23 (60.5%) achieved mucosal healing. Of the 59 patients who achieved clinical remission with thiopurine, 6 patients (10.2%) discontinued the thiopurine therapy because of adverse events.
Conclusions Our study demonstrates the long-term efficacy and safety of thiopurine treatment in patients with bio-naive UC.
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Citations
Citations to this article as recorded by
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Xi Chen, Xiaohua Tang, Sixuan Chen, Yang Ye, Fei Mao
Frontiers in Immunology.2026;[Epub] CrossRef - Thiopurines Have Sustained Long-term Effectiveness in Patients with Inflammatory Bowel Disease, Which is Independent of Disease Duration at Initiation: A Propensity Score Matched Analysis
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Journal of Crohn's and Colitis.2024; 18(2): 192. CrossRef - Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis
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Journal of Gastroenterology and Hepatology.2022; 37(1): 81. CrossRef - Real-World Long-Term Remission Maintenance for 10 Years With Thiopurines in Ulcerative Colitis
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Crohn's & Colitis 360.2021;[Epub] CrossRef - Treatment of Inflammatory Bowel Disease: A Comprehensive Review
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Digestive Diseases and Sciences.2017; 62(2): 473. CrossRef - Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
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Scandinavian Journal of Gastroenterology.2016; 51(9): 1069. CrossRef - Is Long-Term Therapy With Thiopurines Effective for Maintaining Remission in Patients With Moderate-To-Severe Ulcerative Colitis?
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Intestinal Research.2015; 13(3): 191. CrossRef
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