Natural products have been used as drugs for millennia, and the therapeutic potential of natural products has been studied for more than a century. Since the mid-1880s, approximately 60% of drugs have originated from natural products. Recently, the importance of using natural products has increased, as has interest in discovering efficient new drugs. Natural drugs are desirable for the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. This review discusses the discovery and development of drugs derived from natural products for the treatment of inflammatory bowel diseases.

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• Evaluating the Antidiabetic Activity of Aloe niebuhriana Latex in Alloxan‐Induced Diabetic Rats and the Development of a Novel Effervescent Granule‐Based Delivery System
  Bushra Abdulkarim Moharram, Mahmoud Mahyoob Alburyhi, Tareq Al-Maqtari, Abdu Faisal, Sultan Zahiruddin
  The Scientific World Journal.2025;[Epub]     CrossRef
• Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases
  Neeta Solanki, Gaurav Gupta, Dinesh Kumar Chellappan, Sachin Kumar Singh, Monica Gulati, Keshav Raj Paudel, Philip M Hansbro, Kamal Dua, Suraj Bhan, Manisha Saini, Harish Dureja
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(1): 116.     CrossRef
• Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products
  Tenzin Jamtsho, Karma Yeshi, Matthew J. Perry, Alex Loukas, Phurpa Wangchuk
  Pharmaceuticals.2024; 17(3): 283.     CrossRef
• Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
  Rudra Narayan Subudhi, Neelam Poonia, Dilpreet Singh, Vimal Arora
  Natural Products and Bioprospecting.2024;[Epub]     CrossRef
• A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms
  Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz
  Heliyon.2024; 10(15): e35638.     CrossRef
• A Survey of Medicinal Plants in the Treatment of Cough, Cold, and Fever in Gopalganj District, Bangladesh
  
  American Journal of Pure and Applied Biosciences.2024; : 152.     CrossRef
• The potential of natural products to inhibit abnormal aggregation of α-Synuclein in the treatment of Parkinson’s disease
  Kaixia Yang, Zhongyue Lv, Wen Zhao, Guogang Lai, Cheng Zheng, Feiteng Qi, Cui Zhao, Kaikai Hu, Xiao Chen, Fan Fu, Jiayi Li, Guomin Xie, Haifeng Wang, Xiping Wu, Wu Zheng
  Frontiers in Pharmacology.2024;[Epub]     CrossRef
• Anti-inflammatory Effect of Pyrus calleryana var. fauriei on Dextran Sulfate Sodium-induced Acute Colitis in Mice and Lipopolysaccharide-treated RAW 264.7 cells
  Mi-Ra Lee, Bohye Kim, Hee-Jun Kim, Yongjun Lee
  Korean Journal of Medicinal Crop Science.2024; 32(6): 393.     CrossRef
• Phytotherapy and Drugs: Can Their Interactions Increase Side Effects in Cancer Patients?
  Sarah Allegra, Silvia De Francia, Francesca Turco, Ilenia Bertaggia, Francesco Chiara, Tiziana Armando, Silvana Storto, Maria Valentina Mussa
  Journal of Xenobiotics.2023; 13(1): 75.     CrossRef
• Ion exchange pattern-based 18β-glycyrrhetinic acid containing pyridinium salts derivatives as novel antibacterial agents with low toxicity
  Jing-Jing He, Ting Li, Hong-Wu Liu, Lin-Li Yang, Yi-Hong Yang, Qing-Qing Tao, Xiang Zhou, Pei-Yi Wang, Song Yang
  Arabian Journal of Chemistry.2023; 16(6): 104771.     CrossRef
• Effective bioactive compounds and their antiviral properties from some selected aquatic plants through in silico and in vitro approaches
  Kuntal Das, Paramita Das, Supriya Mana
  Aquaculture.2023; 573: 739574.     CrossRef
• Physico-chemical, microbiological, and sensory characteristics of yogurt as affected by various ingredients
  Ricardo S. Aleman, Roberto Cedillos, Ryan Page, Douglas Olson, Kayanush Aryana
  Journal of Dairy Science.2023; 106(6): 3868.     CrossRef
• In vitro Antioxidant Potential and In vivo Analgesic and Anti-Inflammatory Activities of Moroccan Equisetum ramosissimum
  Saida Sissi, Loubna Ait Dra, Soukaina Ouhaddou, Ouhammou Ahmed, Mustapha Larhsini, Mohammed Markouk
  The Natural Products Journal.2023;[Epub]     CrossRef
• Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model
  Gulshan Singh, Hassan Brim, Yeneneh Haileselassie, Sudhir Varma, Aida Habtezion, Mudasir Rashid, Sidhartha R. Sinha, Hassan Ashktorab
  Current Issues in Molecular Biology.2023; 45(7): 5558.     CrossRef
• Mechanisms and therapeutic actions of edible fruits in inflammatory bowel disease: A review of pre-clinical studies
  Karuppusamy Arunachalam, Puthanpura Sasidharan Sreeja, Xuefei Yang
  Food Chemistry Advances.2023; 3: 100498.     CrossRef
• Aproximaciones evolutivas en etnobotánica de plantas medicinales y bioprospección
  Madeleyne Cupido, José Arturo De-Nova, Virginia Gabriela Cilia-López
  Botanical Sciences.2023; 102(1): 26.     CrossRef
• Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.
  Kehinde Oluwakemi Fagbemi, Daniel Ayandiran Aina, Morenike Olutunmbi Adeoye-Isijola, Kubendran Kista Naidoo, Roger Murugas Coopoosamy, Olufunmiso Olusola Olajuyigbe
  Scientific Reports.2022;[Epub]     CrossRef
• Molecular docking investigation of anti-inflammatory herbal compounds as potential LOX-5 and COX-2 inhibitors
  Liliia Vyshnevska, Hanna I. Severina, Yuliya Prokopenko, Alexander Shmalko
  Pharmacia.2022; 69(3): 733.     CrossRef
• A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities
  Yuebin Liu, Ruilong Sheng, Junting Fan, Ruihua Guo
  Mini-Reviews in Medicinal Chemistry.2022; 22(15): 2024.     CrossRef
• Effects of molecular weight on intestinal anti-inflammatory activities of β-D-glucan from Ganoderma lucidum
  Yanfang Liu, Qingjiu Tang, Jie Feng, Jing Liu, Chuanhong Tang, Mengqiu Yan, Shuai Zhou, Liping Liu, Jing Zhou, Jingsong Zhang
  Frontiers in Nutrition.2022;[Epub]     CrossRef
• Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice
  Laryssa Regis Bueno, Bruna da Silva Soley, Kahlile Youssef Abboud, Isabella Wzorek França, Karien Sauruk da Silva, Natalia Mulinari Turin de Oliveira, Juliana Santos Barros, Marcelo Biondaro Gois, Lucimara Mach Côrtes Cordeiro, Daniele Maria-Ferreira, And
  Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
• Recent progress of bacterial FtsZ inhibitors with a focus on peptides
  Huihui Han, Zhenlong Wang, Ting Li, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, Xiumin Wang, Jianhua Wang
  The FEBS Journal.2021; 288(4): 1091.     CrossRef
• Rational Optimization of 1,2,3-Triazole-Tailored Carbazoles As Prospective Antibacterial Alternatives with Significant In Vivo Control Efficiency and Unique Mode of Action
  Xing Huang, Hong-Wu Liu, Zhou-Qing Long, Zhen-Xing Li, Jian-Jun Zhu, Pei-Yi Wang, Pu-Ying Qi, Li-Wei Liu, Song Yang
  Journal of Agricultural and Food Chemistry.2021; 69(16): 4615.     CrossRef
• Molecular Engineering of Curcumin, an Active Constituent of Curcuma longa L. (Turmeric) of the Family Zingiberaceae with Improved Antiproliferative Activity
  Amena Ali, Abuzer Ali, Abu Tahir, Md. Afroz Bakht, Salahuddin, Mohamed Jawed Ahsan
  Plants.2021; 10(8): 1559.     CrossRef
• Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems
  Disha Varijakzhan, Chou-Min Chong, Aisha Abushelaibi, Kok-Song Lai, Swee-Hua Erin Lim
  Molecules.2020; 25(5): 1126.     CrossRef
• Anti‐inflammatory effect of hydrolyzed celery leaves extract in murine primary splenocyte
  Jae Young Shin, Denis Nchang Che, Byoung Ok Cho, Hyun Ju Kang, Ji‐su Kim, Seon Il Jang
  Journal of Food Biochemistry.2019;[Epub]     CrossRef
• Design, Synthesis, Antibacterial Evaluation, and Induced Apoptotic Behaviors of Epimeric and Chiral 18β-Glycyrrhetinic Acid Ester Derivatives with an Isopropanolamine Bridge against Phytopathogens
  Meng Xiang, Xiang Zhou, Ting-Rong Luo, Pei-Yi Wang, Li-Wei Liu, Zhong Li, Zhi-Bing Wu, Song Yang
  Journal of Agricultural and Food Chemistry.2019; 67(48): 13212.     CrossRef
• GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.
  Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Abdul Sadiq, Muhammad Shahid, Waqar Ahmad, Ihsan Ullah, Ashfaq Ahmad, Nawazish-i-Husain Syed
  Frontiers in Chemistry.2017;[Epub]     CrossRef
• Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
  Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
  Molecular Medicine Reports.2017; 16(6): 9224.     CrossRef
• Dietary supplementation of GrandFusion® mitigates cerebral ischemia-induced neuronal damage and attenuates inflammation
  Jin Yu, Hong Zhu, Sebastiano Gattoni-Celli, Saeid Taheri, Mark Stephen Kindy
  Nutritional Neuroscience.2016; 19(7): 290.     CrossRef
• The Traditional Medicine and Modern Medicine from Natural Products
  Haidan Yuan, Qianqian Ma, Li Ye, Guangchun Piao
  Molecules.2016; 21(5): 559.     CrossRef
• Orally available extract from Brassica oleracea var. capitata rubra attenuates experimental colitis in mouse models of inflammatory bowel diseases
  Marta Zielińska, Urszula Lewandowska, Anna Podsędek, Adam I. Cygankiewicz, Damian Jacenik, Maciej Sałaga, Radzisław Kordek, Wanda M. Krajewska, Jakub Fichna
  Journal of Functional Foods.2015; 17: 587.     CrossRef
• Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway
  Tatiane Oliveira, Camila A. Figueiredo, Carlos Brito, Alexander Stavroullakis, Ana Carolina Ferreira, Getulio Nogueira-Filho, Anuradha Prakki
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Rice prolamin extract ameliorates acute murine colitis by inhibiting nuclear factor-kappa B and modulating intestinal apoptosis and cell proliferation
  C-Y Chung, Y-L Park, N Kim, H-H Oh, D-S Myung, J-S Kim, S-B Cho, W-S Lee, H-S Kim, B-W Ahn, Y-E Joo
  Clinical and Experimental Immunology.2014; 178(3): 537.     CrossRef