Intestinal Research

Original Article

Microbiota

Development and diversity of lactic acid producing bacteria and bifidobacteria in healthy full term Indian infants from Himachal Pradesh: Sampan Attri, Rishi Mahajan, Gunjan Goel; Intest Res 2018;16(4):529-536. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00050

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Background/Aims
The initial microbial colonization is a crucial step for the healthy development of an infant. Previous studies from India reported the dominance of target microbial species among Indian infants without any analysis on the diversity of target groups. This is the first study from India with an objective to investigate the establishment and diversity of lactic acid producing bacteria (LAB) and bifidobacteria in vaginally delivered, full term, breastfed infants for the first 4 months after birth.
Methods
Present study used polymerase chain reaction-denaturating gradient gel electrophoresis (PCR-DGGE) based sequence analysis of LAB and bifidobacteria in healthy infants. The results were used to compare the development and early colonization by LAB and bifidobacteria using diversity indices during the initial months of development of gut microbiota in infants.
Results
During the first 4 months, the Shannon diversity index (H) of LAB increased from 1.16 to 1.318 and for bifidobacteria the H increased from 0.975 to 1.293 (P<0.05). Higher Sorenson’s pair wise similarity coefficient was observed for LAB and bifidobacteria during 2nd and the 3rd month. The species of the genera Enterococcus, Streptococcus, and Lactobacillus were dominant among the LAB group whereas Bifidobacterium breve was dominant species among Bifidobacterium group.
Conclusions
Our results indicate that in breast fed infants, the microbial diversity of LAB and bifidobacteria increased during the period of study.

Citations

Citations to this article as recorded by

Development and Functions of the Infant Gut Microflora: Westernvs. Indian Infants
Lalit Bharadia, Neha Agrawal, Nandan Joshi
International Journal of Pediatrics.2020; 2020: 1. CrossRef

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