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Microbiota
The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment
Sang Hoon Kim, Yun Jeong Lim
Intest Res 2022;20(1):31-42.   Published online May 21, 2021
DOI: https://doi.org/10.5217/ir.2021.00034
AbstractAbstract PDFPubReaderePub
The role of gut microbiome-intestinal immune complex in the development of colorectal cancer and its progression is well recognized. Accordingly, certain microbial strains tend to colonize or vanish in patients with colorectal cancer. Probiotics, prebiotics, and synbiotics are expected to exhibit both anti-tumor effects and chemopreventive effects during cancer treatment through mechanisms such as xenometabolism, immune interactions, and altered eco-community. Microbial modulation can also be safely used to prevent complications during peri-operational periods of colorectal surgery. A deeper understanding of the role of intestinal microbiota as a target for colorectal cancer treatment will lead the way to a better prognosis for colorectal cancer patients.

Citations

Citations to this article as recorded by  
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  • Insomnia and Gut Microbiota
    Nazime Mercan Doğan, Naime Nur Bozbeyoğlu Kart
    Journal of Turkish Sleep Medicine.2024; 11(1): 1.     CrossRef
  • Species-level identification of enterotype-specific microbial markers for colorectal cancer and adenoma
    Ünzile Güven Gülhan, Emrah Nikerel, Tunahan Çakır, Fatih Erdoğan Sevilgen, Saliha Durmuş
    Molecular Omics.2024; 20(6): 397.     CrossRef
  • Fermented African Locust Bean (Iru), a Potential Dietary Prebiotic and Probiotic
    Paulina Adeniyi
    International Journal of Nutrition and Food Sciences.2024; 13(3): 114.     CrossRef
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    Bailee Kim, Angel Song, Andrew Son, Yonghwan Shin
    Medicine.2024; 103(29): e39051.     CrossRef
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    Makan Cheraghpour, Nayeralsadat Fatemi, Mahdi Shadnoush, Ghazaleh Talebi, Sascha Tierling, Luis G. Bermúdez-Humarán
    Medical Oncology.2024;[Epub]     CrossRef
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    Yefeng Wang, Jing Guo, Yu Fu, Yuying Li, Chongming Wu
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  • A New Combination of Bifidobacterium bifidum and Lactococcus lactis Strains with Synergistic Effects Alleviates Colitis-Associated Colorectal Cancer
    Jiacui Shang, Lijun Liu, Shuo Yang, Bofan Duan, Shuiqi Xie, Xiangchen Meng
    Foods.2024; 13(19): 3054.     CrossRef
  • THE PROTECTIVE ROLE OF INTESTINAL MICROBIOTA IN COLORECTAL CANCER TREATMENT: A SCOPING REVIEW
    Jéssica Rosa Thiesen Cunha, Elissandra Maria Faiz, Elizete Maria de Souza Bueno, Eliana Rosa da Fonseca, Thais Ortiz Hammes, Adriana Serdotte Freitas Cardoso, Leticia Becker Vieira, Isabel Cristina Echer
    Texto & Contexto - Enfermagem.2024;[Epub]     CrossRef
  • O PAPEL PROTETIVO DA MICROBIOTA INTESTINAL NO TRATAMENTO DO CÂNCER COLORRETAL: REVISÃO DE ESCOPO
    Jéssica Rosa Thiesen Cunha, Elissandra Maria Faiz, Elizete Maria de Souza Bueno, Eliana Rosa da Fonseca, Thais Ortiz Hammes, Adriana Serdotte Freitas Cardoso, Leticia Becker Vieira, Isabel Cristina Echer
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    Yong Eun Park
    The Korean Journal of Internal Medicine.2023; 38(2): 264.     CrossRef
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    Hyun Woo Ma, Jung Min Kim, Da Hye Kim, I Seul Park, Ji Hyung Kim, Ki Cheong Park, Dong Hyuk Seo, Jae Hyeon Kim, Xiumei Che, Tae Il Kim, Jae Hee Cheon, Seung Won Kim
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  • Pterostilbene and Probiotic Complex in Chemoprevention of Putative Precursor Lesions for Colorectal Cancer in an Experimental Model of Intestinal Carcinogenesis with 1,2-Dimethylhydrazine
    Márcio Alencar Barreira, Márcio Wilker Soares Campelo, Conceição da Silva Martins Rebouças, Antoniella Souza Gomes Duarte, Maria Lucianny Lima Barbosa, Said Gonçalves da Cruz Fonseca, Raphaela Ribeiro Queiroz, Érica Uchoa Holanda, Ana Beatriz Aragão de Va
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  • Probiotic-Derived Bioactive Compounds in Colorectal Cancer Treatment
    Christina Thoda, Maria Touraki
    Microorganisms.2023; 11(8): 1898.     CrossRef
  • Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms
    Sang Hoon Kim, Dong Hwan Park, Yun Jeong Lim
    The Korean Journal of Gastroenterology.2023; 82(2): 73.     CrossRef
  • Gut Microbiome and Colorectal Cancer
    Tae-Geun Gweon
    The Korean Journal of Gastroenterology.2023; 82(2): 56.     CrossRef
  • Calcium, Vitamin D, and Colorectal Cancer
    Young-Jo Wi, Soo-Young Na
    The Korean Journal of Gastroenterology.2023; 82(2): 47.     CrossRef
  • Comments on Efficacy of a Synbiotic Containing Lactobacillus paracasei DKGF1 and Opuntia humifusa in Elderly Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
    Kwang Woo Kim
    Gut and Liver.2023; 17(6): 954.     CrossRef
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    Yongbo Kang, Xing Kang, Yue Cai
    Clinics and Research in Hepatology and Gastroenterology.2022; 46(1): 101834.     CrossRef
  • How to Improve Health with Biological Agents—Narrative Review
    Anna Zawistowska-Rojek, Stefan Tyski
    Nutrients.2022; 14(9): 1700.     CrossRef
  • Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment
    Na Yuan, Xiaoyan Li, Meng Wang, Zhilin Zhang, Lu Qiao, Yamei Gao, Xinjian Xu, Jie Zhi, Yang Li, Zhongxin Li, Yitao Jia
    Gut and Liver.2022; 16(4): 575.     CrossRef
  • Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
    Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Cancer Immunotherapy: Fecal Microbiota Transplantation Brings Light
    Jie Zhang, Kanghui Wu, Cuicui Shi, Guangming Li
    Current Treatment Options in Oncology.2022; 23(12): 1777.     CrossRef
  • The microbiome of diverticulitis
    Nimalan Arjun Jeganathan, Emily R Davenport, Gregory S Yochum, Walter A Koltun
    Current Opinion in Physiology.2021; 22: 100452.     CrossRef
  • The Interaction Between the Microbiome and Tumors
    Yawen Zong, Yujie Zhou, Binyou Liao, Min Liao, Yangyang Shi, Yu Wei, Yuyao Huang, Xuedong Zhou, Lei Cheng, Biao Ren
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Anti-inflammatory properties of Escherichia coli Nissle 1917 in a murine colitis model
    Jihye Park, Da Hye Kim, Soochan Kim, Hyun Woo Ma, I Seul Park, Mijeong Son, Ji Hyung Kim, Yoojin Shin, Seung Won Kim, Jae Hee Cheon
    Intestinal Research.2021; 19(4): 478.     CrossRef
  • Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer
    Laure Campillo-Gimenez, David Rios-Covian, Jesus Rivera-Nieves, Hiroshi Kiyono, Hiutung Chu, Peter B. Ernst
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
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Original Articles
Microbiota
Evaluation of commercial probiotic lactic cultures against biofilm formation by Cronobacter sakazakii
Anubhav Jamwal, Kavita Sharma, Rajni Chauhan, Saurabh Bansal, Gunjan Goel
Intest Res 2019;17(2):192-201.   Published online December 3, 2018
DOI: https://doi.org/10.5217/ir.2018.00106
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Cronobacter sakazakii, an emergent pathogen is considered as a major concern to infants and neonates fed on reconstituted powdered infant milk formula. In conjunction with many other factors, biofilm forming capacity adds to its pathogenic potential. In view of the facts that infants are at highest risk to C. sakazakii infections, and emerging antibiotic resistance among pathogens, it is imperative to evaluate probiotic cultures for their efficacy against C. sakazakii. Therefore, pure probiotic strains were isolated from commercial probiotic products and tested for their antimicrobial and anti-biofilm activities against C. sakazakii.
Methods
A total of 6 probiotic strains were tested for their antibiotic susceptibility followed by antimicrobial activity using cell-free supernatant (CFS) against C. sakazakii. The inhibitory activity of CFS against biofilm formation by C. sakazakii was determined using standard crystal violet assay and microscopic observations.
Results
All the probiotic strains were sensitive to ampicillin, tetracycline, vancomycin and carbenicillin whereas most of the strains were resistant to erythromycin and novobiocin. Four of the 6 probiotic derived CFS possessed antimicrobial activity against C. sakazakii at a level of 40 μL. A higher biofilm inhibitory activity (>80%) was observed at initial stages of biofilm formation with weaker activity during longer incubation upto 48 hours (50%–60%).
Conclusions
The study indicated the efficacy of isolated commercial probiotics strains as potential inhibitor of biofilm formation by C. sakazakii and could be further explored for novel bioactive molecules to limit the emerging infections of C. sakazakii.

Citations

Citations to this article as recorded by  
  • 2′-Fucosyllactose as a prebiotic modulates the probiotic responses of Bifidobacterium bifidum
    Jingfang Du, Hong Yang
    Current Research in Food Science.2025; 10: 100975.     CrossRef
  • Macro/Microgel‐Encapsulated, Biofilm‐Armored Living Probiotic Platform for Regenerating Bacteria‐Infected Diabetic Wounds
    Huilong Xin, Zhe Cai, Jiahui Hao, Jing An, Yi Li, Min Wen, Zhaojun Jia
    Advanced Healthcare Materials.2025;[Epub]     CrossRef
  • Exploring the potential of Weissella paramesenteroides UFTM 2.6.1 in disrupting quorum sensing and attenuating virulence in Listeria monocytogenes
    Isabela Sguilla Rotta, Sthefânia Dalva da Cunha Rezende, Hugo Felix Perini, Marcos Vinicius da Silva, Felipe Alves de Almeida, Uelinton Manoel Pinto, Alessandra Barbosa Ferreira Machado, Aline Dias Paiva
    Frontiers in Microbiology.2025;[Epub]     CrossRef
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    Jingyan Zhang, Tao Hu, Qingshen Sun
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    Arezou Rouhi, Fereshteh Falah, Marjan Azghandi, Behrooz Alizadeh Behbahani, Seyed Ali Mortazavi, Farideh Tabatabaei-Yazdi, Alireza Vasiee
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  • 309 Download
  • 20 Web of Science
  • 22 Crossref
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A Double-Blind, Randomized, Active Drug Comparative, Parallel-Group, Multi-Center Clinical Study to Evaluate the Safety and Efficacy of Probiotics (Bacillus licheniformis, Zhengchangsheng® capsule) in Patients with Diarrhea
Jun Heo, Sung Kook Kim, Kyung Sik Park, Hye Kyung Jung, Joong Goo Kwon, Byung Ik Jang
Intest Res 2014;12(3):236-244.   Published online July 25, 2014
DOI: https://doi.org/10.5217/ir.2014.12.3.236
AbstractAbstract PDFPubReaderePub
<b>Background/Aims</b><br/>

Bacillus Licheniformis, a probiotic used in the treatment of diarrhea, has been shown to suppress the growth of pathologic bacteria. This study was performed to assess the therapeutic efficacy and safety of Zhengchangsheng® (Bacillus Licheniformis) in comparison with another probiotic, Bioflor® (Saccharomyces Boulardii) for the treatment of diarrhea.

Methods

Patients with diarrhea (n=158) were randomized to receive Zhengchangsheng® or Bioflor® for 5 days. The existence or non-existence of formed feces, changes in daily stool frequency, improvement of subjective symptoms, and changes in the severity of diarrhea were compared.

Results

Of the 158 full analysis set (FAS) patient population, 151 patients comprised the per protocol (PP) analysis. The rates of recovered to formed feces in the Bacillus and Saccharomyces groups were 91.0% vs. 95.0% in the FAS (P=0.326) and 90.5% vs. 96.1% in the PP analysis (P=0.169), respectively. The mean duration of diarrhea changing to formed feces was 3.15±1.10 days in the Bacillus group and 3.22±1.01 in the Saccharomyces group (P=0.695, FAS). The frequency of defecation, subjective symptoms, and degree of severe diarrhea were improved in both groups, however, there were no statistically significant differences between the 2 groups. Analysis of the 95% confidence intervals for the differences in the rate of recovery to formed feces between the 2 groups met the criteria for non-inferiority of Bacillus compared to Saccharomyces. No significant adverse events were observed during the study period.

Conclusions

Zhengchangsheng® is not inferior to Bioflor® in therapeutic efficacy and is a safe and useful therapeutic agent for the treatment of diarrhea.

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