Intestinal Research

Original Articles

Health-related quality of life, work productivity, and persisting challenges in treated ulcerative colitis patients: a Japanese National Health and Wellness Survey: Sakiko Hiraoka, Zhezhou Huang, Fei Qin, Fatima Megala Nathan Arokianathan, Kiran Davé, Shweta Shah, Hyunchung Kim; Received July 2, 2024 Accepted October 23, 2024 Published online January 2, 2025; DOI: https://doi.org/10.5217/ir.2024.00104 [Epub ahead of print]

Abstract PDF Supplementary Material PubReader ePub: Background/Aims
Despite available treatments for ulcerative colitis (UC), unmet needs persist among patients in Japan. This study explored the health-related quality of life (HRQoL), work productivity and activity impairment (WPAI), indirect cost, and unmet needs among treated UC patients in Japan.
Methods
This cross-sectional, observational study utilized data from the online 2017, 2019, and 2021 Japan National Health and Wellness Survey. Respondents were aged ≥ 18 years and had undergone or were on UC treatment (5-aminosalicylic acid, steroids, immunomodulators/immunosuppressants, biologics/Janus kinase inhibitors [JAKi]). Demographic, general health, and clinical characteristics, medication adherence, HRQoL, WPAI, and indirect cost were collected and analyzed.
Results
Among 293 treated UC patients, 83.6% were non-biologic/JAKi users, 29.0% had UC ≥ 15 years, 34.8% had moderate-to-severe disease severity, 55.3% experienced ≥ 1 persisting UC symptom, and 91.5% reported UC as bothersome to an extent. Patients reported EuroQoL visual analog scale score of 68.1 and ≥ 35% reported anxiety and depression. Mean work productivity loss was 29.3%, resulting in an annual mean indirect loss of 1.1 million JPY (45.3 thousand USD) per person. Higher WPAI (impairment) was associated with being male, moderate-to-severe disease severity, and low treatment adherence (P< 0.05). Biologics/JAKi users had higher work impairment, and IM/IS users had higher activity impairment than 5-aminosalicylic acid users (P< 0.05).
Conclusions
Despite treatment, Japanese UC patients experienced high disease burden and persistent disease-related challenges. Overall HRQoL were lower than the mean healthy population and work productivity impairment led to high indirect costs. The findings suggest the importance of new interventions for optimizing UC outcomes.

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Early resolution of bowel urgency by budesonide foam enema results in improved quality of life in patients with ulcerative colitis: a multicenter prospective observational study: Taku Kobayashi, Kei Moriya, Toshimitsu Fujii, Shigeki Bamba, Shinichiro Shinzaki, Akihiro Yamada, Takashi Hisabe, Shintaro Sagami, Shuji Hibiya, Takahiro Amano, Noritaka Takatsu, Katsutoshi Inagaki, Ken-ichi Iwayama, Toshifumi Hibi; Received January 11, 2024 Accepted April 29, 2024 Published online July 15, 2024; DOI: https://doi.org/10.5217/ir.2024.00005 [Epub ahead of print]

Abstract PDF Supplementary Material PubReader ePub: Background/Aims
Bowel urgency is an important symptom for quality of life determination in patients with ulcerative colitis (UC). Few clinical studies have focused on bowel urgency as an efficacy endpoint. Budesonide foam enema has shown efficacy for clinical and endoscopic improvement in mild-to-moderate UC. We evaluated the improvement of clinical symptoms (bowel urgency), safety, and treatment impact of twice-daily budesonide foam enema on the quality of life in patients with UC.
Methods
This open-label, multicenter, prospective observational study comprised a 4-week observation period assessing the effectiveness and safety of twice-daily budesonide foam enema. Mild-to-moderate UC patients who had bowel urgency were included. Patients collected data daily in an electronic patient-reported outcome system or logbooks. The primary endpoint was the rate of resolution of bowel urgency at the end of the 4-week observation period. The rate of bowel incontinence was also assessed.
Results
Sixty-one patients were enrolled. Of patients with a final evaluation, the rate of resolution of bowel urgency was 58.5% (31/53; 95% confidence interval, 44.1%–71.9%). Bowel urgency decreased over time, with a significant difference observed on day 7 versus day 0. Bowel incontinence showed a decreasing trend from day 5, with a significant difference confirmed on day 12 versus day 0. The clinical remission rate was 64.4% (38/59; 95% confidence interval, 50.9%–76.4%). One adverse event not related to budesonide rectal foam occurred.
Conclusions
The findings suggest that bowel urgency can be improved early with twice-daily budesonide foam enema. No new safety signals were observed.

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IBD

Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity: Alex Barnes, Jane M Andrews, Sutapa Mukherjee, Robert V Bryant, Peter Bampton, Robert J. Fraser, Réme Mountifield; Intest Res 2024;22(1):104-114. Published online November 1, 2023; DOI: https://doi.org/10.5217/ir.2023.00028

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Insomnia is common in people with chronic medical conditions, such as inflammatory bowel disease (IBD), and is readily treatable through cognitive behavioral therapy for insomnia. This study aimed to describe the associations with insomnia in people with IBD and its relationship to IBD-related disability.
Methods
An online questionnaire was administered through 3 tertiary IBD centers, social media, and Crohn’s Colitis Australia. The questionnaire included the Insomnia Severity Index (ISI), a validated assessment of insomnia. Measures of anxiety, depression, physical activity, and disability were also included. IBD activity was assessed using validated patient reported scores. A multivariate model was constructed for clinically significant insomnia and ISI scores. Subpopulations of Crohn’s disease and ulcerative colitis were considered.
Results
In a cohort of 670 respondents the median age was 41 years (range, 32–70 years), with the majority female (78.4%), the majority had Crohn’s disease (57.3%). Increasingly severe disability was associated with worse insomnia score. Clinically significant insomnia was associated with clinically active IBD, abdominal pain, anxiety, and depression, in a multivariate model. In an ulcerative colitis population, Simple Clinical Colitis Activity Index components of general well-being and urgency were associated with worse ISI score in a model including depression and anxiety. In those with Crohn’s disease, the multivariate model included Harvey Bradshaw Index score in addition to depression and anxiety.
Conclusions
Insomnia is common in people with IBD and is associated with increased disability. Abdominal pain and mental health conditions should prompt consideration for screening for insomnia and referral for cognitive behavioral therapy for insomnia.

Citations

Citations to this article as recorded by

The IBD Clinic of Tomorrow: Holistic, Patient-Centric, and Value-based Care
Benjamin Click, Raymond K. Cross, Miguel Regueiro, Laurie Keefer
Clinical Gastroenterology and Hepatology.2025; 23(3): 419. CrossRef
Chronic Poor Sleep is Associated with Increased Disease Activity in Patients with Ulcerative Colitis: Prospective Observational Study in Japan
Hideaki Oyama, Rintaro Moroi, Atsushi Sakuma, Yusuke Shimoyama, Hiroshi Nagai, Takeo Naito, Hisashi Shiga, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune
Journal of Crohn's and Colitis.2025;[Epub] CrossRef
Association between depression and anxiety with the risk and flare of inflammatory bowel disease: a systematic review and meta-analysis
Guowei Gong, Cong Xu, Zhenxia Zhang, Yuzhong Zheng
Internal and Emergency Medicine.2025; 20(1): 35. CrossRef
The impact of sleep quality on the prognosis of inflammatory bowel disease commonly overlooked by gastroenterologists
Ji Young Chang
Intestinal Research.2024; 22(1): 5. CrossRef
Sleep quality is associated with reduced quality of life in inflammatory bowel disease through its interaction with pain
Alex Barnes, Robert V Bryant, Sutapa Mukherjee, Paul Spizzo, Réme Mountifield
JGH Open.2024;[Epub] CrossRef
Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review
Wei-wei Tan, Zi-xuan Liu, Xiao-Yan Liu, Wei-bing Zhang, Lie Zheng, Ya-Li Zhang, Yan-Cheng Dai
Pain and Therapy.2024; 13(6): 1447. CrossRef
Impact of Inflammatory Bowel Disease on Patient’s Quality of Life – A Review
Kamila Duszyńska, Karol Dolepski, Alicja Góral, Krystian Żuk, Michał Czachajda
Journal of Health Study and Medicine.2024; 2024(1): 185. CrossRef

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Inflammatory Bowel Diseases

Quality of life in inflammatory bowel diseases: it is not all about the bowel: Ronald Keller, Nazar Mazurak, Laura Fantasia, Stefano Fusco, Nisar P Malek, Jan Wehkamp, Paul Enck, Thomas Klag; Intest Res 2021;19(1):45-52. Published online February 27, 2020; DOI: https://doi.org/10.5217/ir.2019.00135

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
The inflammatory bowel diseases (IBD), ulcerative colitis (UC), and Crohn’s disease (CD) are chronic diseases mostly affecting young patients. As they are diseases accompanying patients for their entire life, and the quality of life (QUOL) interacts with disease activity, improving QUOL should be one of the main goals of therapy. This study aims to identify factors contributing to good or impaired QUOL.
Methods
Questionnaires addressing health-related QUOL and other psychological and social features were positioned on our institutions’ webpage and on the webpage of the largest self-help group for IBD in Germany. Patients were subdivided according to their QUOL score with a cutoff of <60. We used the Short Inflammatory Bowel Disease Questionnaire, the Assessment of the Demand for Additional Psychological Treatment, and the Fear of Progression Questionnaire Short Form.
Results
High numbers of patients in both subgroups showed an impaired QUOL (87.34% in UC, 91.08% in CD). Active extraintestinal manifestations, smoking, high fear of progression and high demand for psychotherapy were associated with reduced QUOL. In addition, polypharmacological interventions did not result in a good QUOL, but ostomies are linked to improved QUOL especially in CD patients.
Conclusions
Scores used in clinical day-to-day-practice mainly focusing on somatic factors do not sufficiently address important aspects concerning QUOL. Most importantly, extraintestinal manifestations show a hitherto underestimated impact on QUOL.

Citations

Citations to this article as recorded by

Self-perception and adjustment to Crohn's disease in emerging and young adults: The clinical and psychosocial associated factors
Nathalie Touma, Carolina Baeza-Velasco
Pratiques Psychologiques.2025; 31(1): 41. CrossRef
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Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia, Guido Daniele Villani, Matteo Megna, Sara Cacciapuoti, Francesca Foglia, Rosario Peluso, Ermelinda D’Alessandro, Mario Ferrante, Anna Testa, Alessia Dalila Guarino, Antonio Rispo, Fabiana Castiglion
Therapeutic Advances in Gastroenterology.2025;[Epub] CrossRef
Evolution of Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study
Alex Barenboim, Tali Epstein Weiss, Orestis Argyriou, Nathaniel Aviv Cohen, Yehuda Kariv, Meir Zemel, Eran Itzkowitz, Ron Greenberg, Noam Goder, Sara Borok, Kapil Sahnan, Hagit Tulchinsky, Nitsan Maharshak
Inflammatory Bowel Diseases.2025;[Epub] CrossRef
Beyond the Gut: A Systematic Review and Meta-analysis of Advanced Therapies for Inflammatory Bowel Disease-associated Extraintestinal Manifestations
Ágnes Eszter Tímár, Andrea Párniczky, Kinga Anna Budai, Márk Viktor Hernádfői, Emese Kasznár, Péter Varga, Péter Hegyi, Szilárd Váncsa, Réka Tóth, Dániel Sándor Veres, Miklós Garami, Katalin Eszter Müller
Journal of Crohn's and Colitis.2024; 18(6): 851. CrossRef
The association between fear of progression and medical coping strategies among people living with HIV: a cross-sectional study
Bing Li, Xiaoli Lin, Suling Chen, Zhe Qian, Houji Wu, Guichan Liao, Hongjie Chen, Zixin Kang, Jie Peng, Guangyu Liang
BMC Public Health.2024;[Epub] CrossRef
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Xin Hu, Liyuan Xu
Journal of Advanced Nursing.2024; 80(10): 4147. CrossRef
Risk Factors of Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
Jiyoung Yoon, Seung Wook Hong, Kyung-Do Han, Seung-Woo Lee, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim, Hyuk Yoon
Gut and Liver.2024; 18(3): 489. CrossRef
Nutritional Profile, Disease Severity, and Quality of Life of Patients with Inflammatory Bowel Disease: A Case–Control Study
Lea N. Sayegh, Firas Haddad, Layane Bou Jaoude, Nicole Fakhoury-Sayegh, Gessica N. H. A. Heraoui, Zainab Nasrallah, Charbel Chidiac, Rashad Nawfal, Fadi F. Francis, Fadi H. Mourad, Jana G. Hashash
Nutrients.2024; 16(12): 1826. CrossRef
Development and Assessment of a Novel Ulcerative Colitis–Specific Quality of Life Questionnaire: A Prospective, Multi-Institutional Study
Jihye Park, Hyun-Soo Zhang, Chung Mo Nam, Joo Sung Kim, Young-Ho Kim, Dong Il Park, Byong Duk Ye, Yoon Tae Jeen, Sehyun Kim, Jae Hee Cheon
Yonsei Medical Journal.2024; 65(11): 636. CrossRef
Comprehensive analysis of psychological symptoms and quality of life in early patients with IBD: a multicenter study from China
Yupei Liu, Jiaming Hu, Shan Tian, Jixiang Zhang, Ping An, Yanrui Wu, Zhongchun Liu, Changqing Jiang, Jie Shi, Kaichun Wu, Weiguo Dong
BMC Psychiatry.2024;[Epub] CrossRef
Evaluation of the Effect of Probiotic Supplementation on Intestinal Barrier Integrity and Epithelial Damage in Colitis Disease: A Systematic Review
Dilek Sivri, Betül Şeref, Melike Şare Bulut, Makbule Gezmen Karadağ
Nutrition Reviews.2024;[Epub] CrossRef
Potential of Gut Microbe-Derived Extracellular Vesicles to Differentiate Inflammatory Bowel Disease Patients from Healthy Controls
Min Heo, Young Soo Park, Hyuk Yoon, Nam-Eun Kim, Kangjin Kim, Cheol Min Shin, Nayoung Kim, Dong Ho Lee
Gut and Liver.2023; 17(1): 108. CrossRef
Obesity and novel management of inflammatory bowel disease
Jee Hyun Kim, Chang-Myung Oh, Jun Hwan Yoo
World Journal of Gastroenterology.2023; 29(12): 1779. CrossRef
A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms
E-Liisa Laakso, Tatjana Ewais
Biomedicines.2023; 11(5): 1497. CrossRef
Psychoemotional disorders of patients with inflammatory bowel diseases: prevalence, pathogenesis and treatment options
Igor G. Bakulin, Venera Sh. Stamboltsyan, Inna A. Oganezova
Russian Family Doctor.2023; 27(2): 23. CrossRef
CE: Nursing Care for Patients After Ostomy Surgery
Heidi H. Cross
AJN, American Journal of Nursing.2023; 123(8): 34. CrossRef
Efficacy and Safety of Infliximab in Intestinal Behçet’s Disease: A Multicenter, Phase 3 Study (BEGIN)
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim
Gut and Liver.2023; 17(5): 777. CrossRef
Validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9)
Dekta Filantropi Esa, Hamzah Shatri, Cleopas Martin Rumende, Adityo Susilo, Hasan Maulahela, Achmad Fauzi, Marcellus Simadibrata
Medical Journal of Indonesia.2023; 32(3): 168. CrossRef
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Seok-Young Kim, Seung Yong Shin, Maham Saeed, Ji Eun Ryu, Jung-Seop Kim, Junyoung Ahn, Youngmi Jung, Jung Min Moon, Chang Hwan Choi, Hyung-Kyoon Choi
Metabolites.2023; 14(1): 2. CrossRef
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Vítor Macedo Silva, Marta Freitas, Pedro Boal Carvalho, Francisca Dias de Castro, Tiago Cúrdia Gonçalves, Bruno Rosa, Maria João Moreira, José Cotter
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Catherine Rowan, Ryan Ungaro, Saurabh Mehandru, Jean-Frederic Colombel
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Journal of Clinical Medicine.2022; 11(11): 3034. CrossRef
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Catherine Rowan, Robert Hirten
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Jaeyoung Chun
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Jose María Huguet, Xavier Cortés, Marta Maia Bosca-Watts, Marian Aguas, Nuria Maroto, Lidia Martí, Cirilo Amorós, Jose María Paredes
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Tiziana Larussa, Danilo Flauti, Ludovico Abenavoli, Luigi Boccuto, Evelina Suraci, Raffaella Marasco, Maria Imeneo, Francesco Luzza
Journal of Clinical Medicine.2020; 9(8): 2416. CrossRef

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28 Web of Science
30 Crossref

IBD

Health-related quality of life of patients with inflammatory bowel disease in Singapore: Prisca Yue Min Ho, Wenjia Hu, Ying Yun Lee, Chuxi Gao, Yan Zhi Tan, Hua Heng Cheen, Hwee Lin Wee, Teong Guan Lim, Wan Chee Ong; Intest Res 2019;17(1):107-118. Published online November 12, 2018; DOI: https://doi.org/10.5217/ir.2018.00099

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Inflammatory bowel disease (IBD) is associated with considerable impairment of patients’ health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients’ HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants.
Methods
A prospective, cross-sectional study was conducted at Singapore General Hospital outpatient IBD Centre. The HRQoL of IBD patients was assessed using the short IBD questionnaire (SIBDQ), Short Form-36 physical and mental component summary (SF-36 PCS/MCS) and EuroQol 5-dimensions 3-levels (EQ-5D-3L) and visual analogue scale (VAS). Independent samples t-test was used to compare HRQoL between Crohn’s disease (CD) and ulcerative colitis (UC). Determinants of HRQoL were identified through multiple linear regression.
Results
A total of 195 IBD patients (103 UC, 92 CD) with a mean disease duration of 11.2 years were included. There was no significant difference in HRQoL between patients with UC and CD. Factors that significantly worsened HRQoL were presence of active disease (b=−6.293 [SIBDQ], −9.409 [PCS], −9.743 [MCS], −7.254 [VAS]), corticosteroids use (b=−7.392 [SIBDQ], −10.390 [PCS], −8.827 [MCS]), poor medication adherence (b=−4.049 [SIBDQ], −1.320 [MCS], −8.961 [VAS]), presence of extraintestinal manifestations (b=−13.381 [PCS]), comorbidities (b=−4.531 [PCS]), non-employment (b=−9.738 [MCS], −0.104 [EQ-5D-3L]) and public housing (b=−8.070 [PCS], −9.207 [VAS]).
Conclusions
The HRQoL is impaired in this Asian cohort of IBD. The magnitude of HRQoL impairment was similar in UC and CD. Clinical characteristics were better determinants of patients’ HRQoL than socio-demographic factors. Recognizing the factors that impact patients’ HRQoL would improve the holistic management of IBD patients.

Citations

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Psychometric Evaluation of the Bengali Short Form 12 Version 2 Health Survey in Patients With Inflammatory Bowel Disease
SM Ali Hasan, Chanchal K. Ghosh, Abdur R. Miah, Md Anwarul Kabir
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Quality of life of inflammatory bowel diseases patients in france with EQ-5D-5 L: the QALY-MICI study
H. Sarter, J. Kirschgesner, L. Beaugerie, A. Buisson, C. Gower-Rousseau, Gérard de Pouvourville
Quality of Life Research.2025; 34(2): 405. CrossRef
Gluten-Free Diet and Health-Related Quality of Life: The Validated Hellenic Version of the Celiac Dietary Adherence Test
Emmanuel Psylinakis, Alexios Manidis, Fotios Makris, Nikolaos Thalassinos, Anastasia Markaki, Vasileia Kounelaki, Eirini Sfakianaki, Aspasia Spyridaki
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Health-related quality of life at diagnosis and follow-up in Faroese and Danish patients with inflammatory bowel disease – a Faroese IBD cohort study
Turid Hammer, Frederikke Agerbo Modin, Kári Rubek Nielsen, Jóngerð Midjord, Ebbe Langholz, Vibeke Andersen, Jens Frederik Dahlerup, Jens Kjeldsen, Natalia Pedersen, Pia Munkholm, Johan Burisch
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Filiz Akyüz, Yoon Kyo An, Jakob Begun, Satimai Aniwan, Huu Hoang Bui, Webber Chan, Chang Hwan Choi, Nazeer Chopdat, Susan J Connor, Devendra Desai, Emma Flanagan, Taku Kobayashi, Allen Yu-Hung Lai, Rupert W Leong, Alex Hwong-Ruey Leow, Wai Keung Leung, Ju
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Evolution of Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study
Alex Barenboim, Tali Epstein Weiss, Orestis Argyriou, Nathaniel Aviv Cohen, Yehuda Kariv, Meir Zemel, Eran Itzkowitz, Ron Greenberg, Noam Goder, Sara Borok, Kapil Sahnan, Hagit Tulchinsky, Nitsan Maharshak
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Sihyun Kim, Yu Kyung Jun, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
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Beyond the Gut: A Systematic Review and Meta-analysis of Advanced Therapies for Inflammatory Bowel Disease-associated Extraintestinal Manifestations
Ágnes Eszter Tímár, Andrea Párniczky, Kinga Anna Budai, Márk Viktor Hernádfői, Emese Kasznár, Péter Varga, Péter Hegyi, Szilárd Váncsa, Réka Tóth, Dániel Sándor Veres, Miklós Garami, Katalin Eszter Müller
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Viktoriya Romanukha, Olena Hryniv, Halyna Hvozdetska, Nadiia Baryla, Anna Hrushetska
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Yakup Ulger, Anıl Delik, Hikmet Akkız
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Impact of Nursing Interventions via Telephone and Email on the Quality of Life of Patients with Inflammatory Bowel Disease: Preliminary Results of a Comparative Observational Study
Caterina Mercuri, Vincenza Giordano, Vincenzo Bosco, Nicola Serra, Rocco Spagnuolo, Rita Nocerino, Teresa Rea, Carmen Colaci, Assunta Guillari, Patrizia Doldo, Silvio Simeone
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Jessica Rassart, Carine Van Wanseele, Lynn Debrun, Koen Matthijs, Philip Moons, Liesbet Van Bulck, Seher Arat, Lukas Van Oudenhove, Koen Luyckx
International Journal of Behavioral Medicine.2023; 30(1): 77. CrossRef
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María Belén Novoa Díaz, Pedro Carriere, Claudia Gentili
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Chanchal Kumar Ghosh, Sumona Islam, Nowrin Tabassum, Syed Arafat Mohiuddin, Md. Mosarrof Hossain, Aditi Sarkar, Amit Bari
Cureus.2023;[Epub] CrossRef
Adalimumab versus Infliximab Treatment Outcome in Ulcerative Colitis: Application of EQ-5D, Visual Analogue Scale, and IBDQ-9 Measures: A Prospective Observational Study
Hassan Karami, Farbod Ebadi Fard Azar, Kamran Bagheri Lankarani, Aziz Rezapour, Sulmaz Ghahramani, Abdolvahab Baghbanian
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Kristina Bertl, Georgios Tsakos, Nikolaos Pandis, Anna Bogren, Johan Burisch, Andreas Stavropoulos
Journal of Clinical Periodontology.2023; 50(12): 1601. CrossRef
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Elizabeth Dent, Nicola Davinson, Stephanie Wilkie
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Health-related quality of life among Chinese patients with Crohn’s disease: a cross-sectional survey using the EQ-5D-5L
Ziyun Gao, Pei Wang, Jie Hong, Yuqing Yan, Tianying Tong, Bin Wu, Jun Hu, Zhenhua Wang
Health and Quality of Life Outcomes.2022;[Epub] CrossRef
Health-Related Quality of Life of Patients Treated with Biological Agents and New Small-Molecule Drugs for Moderate to Severe Crohn’s Disease: A Systematic Review
Hasan Aladraj, Mohamed Abdulla, Salman Yousuf Guraya, Shaista Salman Guraya
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Landscape of inflammatory bowel disease in Singapore
Daren Low, Nidhi Swarup, Toshiyuki Okada, Emiko Mizoguchi
Intestinal Research.2022; 20(3): 291. CrossRef
Daily life difficulties among patients with ulcerative colitis in Japan and the United Kingdom: A comparative study
Aki Kawakami, Makoto Tanaka, Kayoko Sakagami, Lee Meng Choong, Reiko Kunisaki, Shin Maeda, Ingvar Bjarnason, Hiroaki Ito, Bu’Hussain Hayee
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Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases: Young Sun Kim, Sung-Ae Jung, Kang-Moon Lee, Soo Jung Park, Tae Oh Kim, Chang Hwan Choi, Hyun Gun Kim, Won Moon, Chang Mo Moon, Hye Kyoung Song, Soo-Young Na, Suk-Kyun Yang; Intest Res 2017;15(3):338-344. Published online June 12, 2017; DOI: https://doi.org/10.5217/ir.2017.15.3.338

Abstract PDF Supplementary Material PubReader ePub

<b>Background/Aims</b><br/>

Inflammatory bowel disease (IBD) is a chronic disabling gastrointestinal disorder that diminishes the quality of life of the affected individuals. Limited data are available regarding the impact of IBD on the daily life of Koreans.

Methods

Self-administered, computer-aided, internet-based questionnaires were distributed to members of a Korean patient organization for IBD from March to April 2013, by the Korean Association for the Study of Intestinal Diseases.

Results

A total of 599 patients with IBD (387 with Crohn's disease [CD] and 212 with ulcerative colitis [UC]) were enrolled. The majority of patients (81%) expressed feelings of fatigue, weakness, and being worn out in their daily lives during times of flare; this percentage was reduced to 61% during remission. Respondents were absent from work or school for an average period of 18 days because of illness, within the first 6 months; the majority of respondents (64%) felt stressed about their absence. Forty-six percent of the respondents reported having received unfair comments at work, or having suffered discrimination. Forty-seven percent of the respondents felt that IBD had negatively affected their income and earnings. Compared with patients with UC, those with CD reported a more frequent negative impact of IBD on work, or more economic burden. More than half of the respondents (61%) reported that IBD had prevented them from making or keeping friends.

Conclusions

IBD significantly impacts daily life, including work, education, and social relationships. Treatment that addresses the full spectrum of life of a patient would be more effective.

Citations

Citations to this article as recorded by

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Inflammatory Bowel Diseases.2024; 30(1): 150. CrossRef
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Journal of Psychosomatic Research.2022; 160: 110983. CrossRef
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