Intestinal Research

Original Articles

Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: a multicenter study with pre- and post-biologics comparison: Wei-Chen Lin, Chun-Chi Lin, Wen-Hung Hsu, Feng-Fan Chiang, Chen-Wang Chang, Tzu-Chi Hsu, Deng-Chyang Wu, Horng-Yuan Wang, Jau-Min Wong, Shu-Chen Wei; Received July 7, 2024 Accepted October 14, 2024 Published online January 24, 2025; DOI: https://doi.org/10.5217/ir.2024.00112 [Epub ahead of print]

Background/Aims
Data from Asia regarding the short-term and long-term outcomes for acute severe ulcerative colitis (ASUC) are limited. We assessed the outcomes of ASUC, identified the risk factors for colectomy, and compared colectomy rates between the pre-biologics and post-biologics eras in Taiwan.
Methods
The patients with an ASUC diagnosis between January 2013 and March 2022 at 5 tertiary medical centers were retrospectively analyzed.
Results
In total, 98 patients were enrolled, with 68.4% diagnosed in the post-biologics era. In 78.6% of the ASUC patients initially received intravenous steroid therapy, for which the success rate was 74.1%. As for rescue therapy, 15 patients (93.8%) received biologics and 1 (6.3%) received cyclosporin. Biologics rescue therapy had a 93.3% success rate. One (1%) mortality due to septic shock occurred. The colectomy rate for index ASUC admission was 11.2%. Patients receiving colectomy were predominantly male (P= 0.012) and at older age (P= 0.016). Higher C-reactive protein (P= 0.035), lower albumin (P= 0.017), and hemoglobin (P= 0.023) levels were associated with colectomy risk. During a median follow-up of 24 months, 13 patients (15.1%) had recurrent ASUC and 23.1% of patients received colectomy. The accumulated colectomy rate at 3 years did not differ between the pre- and post-biologics eras (16.1% vs. 13.4%, P= 0.270).
Conclusions
This is the first Asian study on ASUC to compare colectomy rates between the prebiologics and post-biologics eras, revealing no significant difference. The recurrent ASUC had a higher colectomy rate than the index ASUC.

Citations

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Serological Assessment of Hepatitis in Patients with Inflammatory Bowel Disease in Taiwan: A Retrospective Cohort Analysis
Yueh-An Lee, Hsu-Heng Yen, Yang-Yuan Chen
Life.2025; 15(6): 893. CrossRef

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Miscellaneous

Risk factors for severity of colonic diverticular hemorrhage: Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Toshiki Kojima, Kenta Chuman, Shigeyoshi Yasukawa, Tsuyoshi Beppu, Akihiro Koga, Satoshi Ishikawa, Masahiro Kishi, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Toshiharu Ueki, Masakazu Washio; Intest Res 2018;16(3):458-466. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.458

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Background/Aims

Colonic diverticular hemorrhage (DH) was a rare disease until the 1990s, and its incidence has increased rapidly since 2000 in Japan. In recent years, colonic DH has been the most frequent cause of lower gastrointestinal bleeding (LGIB). Nearly all cases of DH are mild, with the bleeding often stopping spontaneously. Some cases, however, require surgery or arterial embolization. In this study, using a cohort at Fukuoka University Chikushi Hospital, we investigated factors associated with severe colonic DH.

Methods

Among patients with LGIB who underwent colonoscopy at our hospital between 1995 and 2013, DH was identified in 273 patients. Among them, 62 patients (22.7%) were defined as having severe colonic DH according to recurrence of bleeding in a short period, and/or the necessity of transfusion, arterial embolization, or surgery. We then evaluated risk factors for severe DH among DH patients in this retrospective cohort.

Results

Among the 273 patients with DH, use of non-steroidal anti-inflammatory drugs (NSAIDs) (odds ratio [OR], 2.801; 95% confidence interval [CI], 1.164–6.742), Charlson Risk Index (CRI) ≥2 (OR, 3.336; 95% CI, 1.154–7.353), right-sided colonic DH (OR, 3.873; 95% CI, 1.554–9.653), and symptoms of cerebral hypoperfusion (such as light-headedness, dizziness, or syncope) (OR, 2.926; 95% CI, 1.310–6.535) showed an increased risk of severe DH even after controlling for other factors.

Conclusions

Severe DH occurred in 23% of DH patients, and NSAID use, CRI ≥2, right-sided colonic DH, and symptoms of cerebral hypoperfusion are suggested to be predictors of severe DH.

Citations

Citations to this article as recorded by

Clinical Factors Associated with Severity of Colonic Diverticular Bleeding and Impact of Bleeding Site
Hirohito Amano, Takatsugu Yamamoto, Ken Ikusaka, Naoaki Aoki, Miyoko Sakurai, Taku Honda, Kyohei Maruyama, Hitoshi Aoyagi, Akari Isono, Koichiro Abe, Yoshinari Asaoka, Shinya Kodashima, Atsushi Tanaka
Journal of Clinical Medicine.2023; 12(5): 1826. CrossRef
Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study
Dong-Hyun Kim, Yong-Wook Jung, Byung-Chul Jin, Hyung-Hoon Oh, Hyo-Yeop Song, Seong-Jung Kim, Dae-Seong Myung, Sang-Wook Kim, Jun Lee, Geom-Seog Seo, Young-Eun Joo, Hyun-Soo Kim
Journal of Clinical Medicine.2023; 12(19): 6255. CrossRef
Risk factors for patients hospitalized with recurrent colon diverticular bleeding: a single center experience
Hye-Su You, Dong Hyun Kim, Seo-Yeon Cho, Seon-Young Park, Chang Hwan Park, Hyun-Soo Kim, Sung Kyu Choi
Frontiers in Medicine.2023;[Epub] CrossRef
Construction of a Model for Predicting the Severity of Diverticular Bleeding in an Elderly Population
Tomoyuki Okada, Tsuyoshi Mikamo, Ayana Nakashima, Atsushi Yanagitani, Kiwamu Tanaka, Hajime Isomoto
Internal Medicine.2022; 61(15): 2247. CrossRef
Diagnosis and Treatment of Colonic Diverticular Disease
You Sun Kim
The Korean Journal of Gastroenterology.2022; 79(6): 233. CrossRef
Development and Validation of Predictive Assessment of Complicated Diverticulitis Score
Marcello Covino, Valerio Papa, Antonio Tursi, Benedetta Simeoni, Loris Riccardo Lopetuso, Lorenzo Maria Vetrone, Francesco Franceschi, Gianludovico Rapaccini, Antonio Gasbarrini, Alfredo Papa
Journal of Personalized Medicine.2021; 11(2): 80. CrossRef
Risk of Rebleeding in Patients with Small Bowel Vascular Lesions
Akira Harada, Takehiro Torisu, Shin Fujioka, Yuichiro Yoshida, Yasuharu Okamoto, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Kumiko Torisu, Tomohiko Moriyama, Motohiro Esaki, Takanari Kitazono
Internal Medicine.2021; 60(23): 3663. CrossRef
Vegetarianism as a protective factor for asymptomatic colonic diverticulosis in Asians: a retrospective cross-sectional and case-control study
Jihun Bong, Hyoun Woo Kang, Hyeki Cho, Ji Hyung Nam, Dong Kee Jang, Jae Hak Kim, Jun Kyu Lee, Yun Jeong Lim, Moon-Soo Koh, Jin Ho Lee
Intestinal Research.2020; 18(1): 121. CrossRef

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IBD

The incidence and risk factors of venous thromboembolism in Japanese inpatients with inflammatory bowel disease: a retrospective cohort study: Katsuyoshi Ando, Mikihiro Fujiya, Yoshiki Nomura, Yuhei Inaba, Yuuya Sugiyama, Takuya Iwama, Masami Ijiri, Keitaro Takahashi, Kazuyuki Tanaka, Aki Sakatani, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Yusuke Mizukami, Toshikatsu Okumura; Intest Res 2018;16(3):416-425. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.416

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Background/Aims

Venous thromboembolism (VTE) is a major extraintestinal manifestation in inflammatory bowel disease (IBD), regarded as an independent risk factor for VTE according to reports from Western countries. However, the incidence and risk factors of VTE in Asian IBD patients are not fully understood. We aimed to reveal the incidence and risk factors of VTE in Japanese IBD inpatients.

Methods

The incidence of VTE in inpatients with IBD (n=340), gastrointestinal cancers (n=557), and other gastrointestinal diseases (n=569) treated at our hospital from 2009 to 2013 was retrospectively investigated. The characteristics and laboratory data of IBD inpatients with and without VTE were compared in univariate and multivariate analyses. Clinical courses of VTE in IBD were surveyed.

Results

VTE was detected in 7.1% of IBD inpatients, significantly higher than in gastrointestinal cancer inpatients (2.5%) and inpatients with other gastrointestinal diseases (0.88%). The incidence of VTE in ulcerative colitis (UC) patients (16.7%) was much higher than that in those with Crohn's disease (3.6%). In the univariate analysis, the risk factors were an older age, central venous catheter, prednisolone, surgery, low serum albumin, high serum C-reactive protein and D-dimer. According to a multivariate analysis, >50 years of age and surgery were the only risk factors. The in-hospital mortality rate of IBD inpatients with VTE was 4.2%.

Conclusions

The incidence of VTE with IBD, especially UC, was found to be high compared with other digestive disease, which was almost equivalent to that of Western countries. The efficacy of prophylaxis needs to be investigated in Asian IBD patients.

Citations

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Utility of rotational thrombo-elastometry as an objective measure of hypercoagulability in ulcerative colitis
P Krishna Bharadwaj, Ebby George Simon, Rutvi G Dave, Tulasi Geevar, Sukesh C Nair, Joseph AJ, Amit Kumar Dutta, Rajeeb Jaleel, Anoop John, Ajith Thomas, Amith Viswanath
Indian Journal of Gastroenterology.2025;[Epub] CrossRef
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Hajnal Székely, Laura Mária Tóth, Anett Rancz, Anna Walter, Nelli Farkas, Miklós Domonkos Sárközi, Szilárd Váncsa, Bálint Erőss, Péter Hegyi, Pál Miheller
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Francisco A. Guzman-Pruneda, Ambar Garcia, Robert W. Crum, Theresa Chen, Abraham Krikhely, Marc Bessler
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Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study
Wan Feng, Lei Zhu, Song Zhao, Kai Zheng, Luzhou Xu, Hong Shen
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Seminars in Thrombosis and Hemostasis.2023; 49(07): 744. CrossRef
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Yasuhiro Aoki, Hiroki Kiyohara, Yohei Mikami, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
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Federica Melazzini, Francesca Calabretta, Marco Vincenzo Lenti, Antonio Di Sabatino
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Dominic Amakye, Onoriode Kesiena, Ademayowa Ademiluyi, Margaret Gavor, Zahraa Rabeeah
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Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators
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Perioperative Venous Thromboembolism in Ulcerative Colitis: A Multicenter Prospective Study in Japan
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Endoscopy

Prospective analysis of factors associated with inadequate bowel preparation for colonoscopy in actual clinical practice: Dae Hyung Woo, Kyeong Ok Kim, Da Eun Jeong, Yoon Jeong Nam, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim; Intest Res 2018;16(2):293-298. Published online April 30, 2018; DOI: https://doi.org/10.5217/ir.2018.16.2.293

Abstract PDF PubReader ePub

Background/Aims

Inadequate bowel preparation can result in prolonged procedure time and increased missed lesion and complication rates. This prospective study aimed to evaluate bowel preparation quality and identify the predictive factors for inadequate bowel preparation in actual clinical practice.

Methods

We included 399 patients who underwent colonoscopy between June 2015 and July 2016. Using the Aronchick bowel preparation scale, we defined a score ≤2 as adequate preparation and a score >2 as inadequate preparation.

Results

Mean patient age was 58.38±12.97 years; 60.6% were male. Indications for colonoscopy included screening (69.7%) and surveillance after polyp removal (21.3%). A split-dose regimen was prescribed to 55.4% of patients. The inadequate bowel preparation rate was 28.1%. Overall, the median time between the last bowel preparation agent dose and start of colonoscopy was 5.0 hours (range, 1.5–16.0 hours); that of the adequate group was 5.0 hours (range, 1.5–16.0 hours); and that of the inadequate group was 5 hours (range, 2–23 hours). The mean bowel preparation scale score of the ascending colon (1.94±0.25) was significantly higher than that of other colon segments. On multivariate analysis, elderly age, history of cerebrovascular disease, history of gastrectomy or appendectomy, and total preparation solution uptake <2 L were the independent predictors of inadequate bowel preparation.

Conclusions

The inadequate bowel preparation rate was 28.1%. Risk factors included elderly age and history of cerebrovascular disease or abdominal surgery. Patients with these risk factors require special care and education.

Citations

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Strategies to improve screening colonoscopy quality for the prevention of colorectal cancer
Joo Hye Song, Eun Ran Kim
The Korean Journal of Internal Medicine.2024; 39(4): 547. CrossRef
A study on the related influencing factors of the quality of bowel preparation and the compliance of middle-aged and elderly patients for colonoscopy
Shanshan Chen, Tingting Zhang, Saie Zhu, Yi Zhou
Current Medical Research and Opinion.2024; 40(9): 1545. CrossRef
Performance of Computer-Aided Detection and Quality of Bowel Preparation: A Comprehensive Analysis of Colonoscopy Outcomes
Dalton A. Norwood, Shyam Thakkar, Amanda Cartee, Fayez Sarkis, Tatiana Torres-Herman, Eleazar E. Montalvan-Sanchez, Kirk Russ, Patricia Ajayi-Fox, Anam Hameed, Ramzi Mulki, Sergio A. Sánchez-Luna, Douglas R. Morgan, Shajan Peter
Digestive Diseases and Sciences.2024; 69(10): 3681. CrossRef
Optimization of colonoscopy quality: Comprehensive review of the literature and future perspectives
Wen‐Feng Hsu, Han‐Mo Chiu
Digestive Endoscopy.2023; 35(7): 822. CrossRef
Risk Factors Associated with Painful Colonoscopy and Prolonged Cecal Intubation Time in Female Patients
Yasuhiko Hamada, Kyosuke Tanaka, Yohei Ikenoyama, Noriyuki Horiki, Junya Tsuboi, Reiko Yamada, Misaki Nakamura, Hayato Nakagawa
Journal of the Anus, Rectum and Colon.2023; 7(3): 168. CrossRef
The effect of educational compilation through video tutorials and visual AIDS on the quality of bowel preparation in patients undergoing colonoscopy
Jahanbakhsh Amirarsalani, Leyla Alilu, Masoumeh Hemmati-Maslakpak, Javad Rasouli
Acta Facultatis Medicae Naissensis.2023; 40(3): 307. CrossRef
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Qi Wang, Kexin Shen, Bingyuan Fei, Hai Luo, Ruiqi Li, Zeming Wang, Mengqiang Wei, Zhongshi Xie
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Jacob E. Kurlander, Akbar K. Waljee, Stacy B. Menees, Rachel Lipson, Alex N. Kokaly, Andrew J. Read, Karmel S. Shehadeh, Amy Cohn, Sameer D. Saini
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Sung Hoon Jung, Chul-Hyun Lim, Tae-Geun Gweon, Jinsu Kim, Jung Hwan Oh, Kyu-Tae Yoon, Jee Young An, Jeong‑Seon Ji, Hwang Choi
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Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Eun Soo Kim, Yun Jin Chung, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang
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Suh Hyun Choi, Won Eui Yoon, Seung Hyuk Kim, Hee Jun Myung, Seo Hyun Kim, Soon Oh So, Se Hun Kim, Hyun Mi Lee, Yeoun Jung Oh, Jeong Seop Moon, Tae Yeong Park, You Sun Kim
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Shashank Sarvepalli, Ari Garber, Carol A. Burke, Niyati Gupta, Mounir Ibrahim, John McMichael, Gareth Morris-Stiff, Amit Bhatt, John Vargo, Maged Rizk, Michael B. Rothberg
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Chen-Shuan Chung, Chih-Ming Lin, Ming-Shu Chen
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Tae-Geun Gweon, Kyu-Tae Yoon, Chang Hyun Kim, Jin-Jo Kim
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Ji Eun Na, Eun Ran Kim
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Yohan Lee, Haejung Lee
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Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid
Sun Hwa Kim, Eun Ran Kim, Kyunga Kim, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young‐Ho Kim
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Youn I Choi, Jong-Joon Lee, Jun-Won Chung, Kyoung Oh Kim, Yoon Jae Kim, Jung Ho Kim, Dong Kyun Park, Kwang An Kwon
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Medicine.2018; 97(41): e12645. CrossRef

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The submucosal fibrosis: what does it mean for colorectal endoscopic submucosal dissection?: Eun Kyoung Kim, Dong Soo Han, Youngouk Ro, Chang Soo Eun, Kyo-Sang Yoo, Young-Ha Oh; Intest Res 2016;14(4):358-364. Published online October 17, 2016; DOI: https://doi.org/10.5217/ir.2016.14.4.358

Abstract PDF PubReader

Background/Aims

Endoscopic submucosal dissection (ESD) allows removal of colorectal epithelial neoplasms en bloc regardless of size. Colorectal ESD is a difficult procedure because of technical difficulties and risks of complications. This study aimed to assess the relationship between ESD outcome and degree of submucosal fibrosis.

Methods

Patients with colorectal tumors undergoing ESD and their medical records were reviewed retrospectively. The degree of submucosal fibrosis was classified into three types. The relationship between ESD outcome and degree of submucosal fibrosis was analyzed.

Results

ESD was performed in 158 patients. Thirty-eight cases of F0 (no) fibrosis (24.1%) and 46 cases of F2 (severe) fibrosis (29.1%) were observed. Complete resection was achieved for 138 lesions (87.3%). Multivariate analysis demonstrated that submucosal invasion of tumor and histology of carcinoma were independent risk factors for F2 fibrosis. Severe fibrosis was an independent risk factor for incomplete resection.

Conclusions

Severe fibrosis is an important factor related to incomplete resection during colorectal ESD. In cases of severe fibrosis, the rate of complete resection was low even when ESD was performed by an experienced operator. Evaluation of submucosal fibrosis may be helpful to predict the submucosal invasion of tumors and technical difficulties in ESD.

Citations

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Masatake Kuroha, Hisashi Shiga, Yoshitake Kanazawa, Hiroshi Nagai, Tomoyuki Handa, Ryo Ichikawa, Motoyuki Onodera, Takeo Naito, Rintaro Moroi, Tomoya Kimura, Katsuya Endo, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune
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Déborah Roland, Gabriel Rahmi, Enrique Pérez-Cuadrado-Robles, Guillaume Perrod, Jérémie Jacques, Maximilien Barret, Sarah Leblanc, Arthur Berger, Jérémie Albouys, Stanislas Chaussade, Christophe Cellier
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Do we need colonoscopy verification in patients with fundic gland polyp?: Hee Sook Lee, Younjeong Choi, Ja Young Jung, Young-Jun Sung, Dong Won Ahn, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Seong-Joon Koh, Ji Won Kim; Intest Res 2016;14(2):172-177. Published online April 27, 2016; DOI: https://doi.org/10.5217/ir.2016.14.2.172

Abstract PDF PubReader ePub

Background/Aims

The aim of this study was to evaluate the prevalence of colorectal neoplasia in subjects with fundic gland polyps (FGPs) and the relationship between FGPs and colorectal neoplasia in Korea.

Methods

We analyzed 128 consecutive patients with FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years) and sex-matched controls were identified from among patients with hyperplastic polyps, gastric neoplasms, and healthy controls. Clinical characteristics were reviewed from medical records, colonoscopic findings, pathologic findings, and computed tomography images. The outcome was evaluated by comparison of advanced colonic neoplasia detection rates.

Results

Of the 128 patients, seven (5.1%) had colon cancers and seven (5.1%) had advanced adenomas. A case-control study revealed that the odds of detecting a colorectal cancer was 3.8 times greater in patients with FGPs than in the age- and sex-matched healthy controls (odds ratio [OR], 3.80; 95% confidence interval [CI], 1.09–13.24; P =0.04) and 4.1 times greater in patients with FGPs than in healthy controls over 50 years of age (OR, 4.10; 95% CI, 1.16–14.45; P =0.04). Among patients with FGPs over 50 years old, male sex (OR, 4.83; 95% CI, 1.23–18.94; P =0.02), and age (OR, 9.90; 95% CI, 1.21–81.08; P =0.03) were associated with an increased prevalence of advanced colorectal neoplasms.

Conclusions

The yield of colonoscopy in colorectal cancer patients with FGPs was substantially higher than that in average-risk subjects. Colonoscopy verification is warranted in patients with FGPs, especially in those 50 years of age or older.

Citations

Citations to this article as recorded by

Current Guidelines and Advances in the Management of Fundic Gland Polyps
Majed Ali, Lynn Srour, Mustapha Bitar, Karam Karam, Ihab I. El Hajj, Elias Fiani
Journal of Gastroenterology and Hepatology.2025; 40(6): 1374. CrossRef
Cold snare polypectomy for fundic gland polyps
Chi‐Hung Chen, Jen‐Chieh Huang, Jeng‐Shiann Shin
Advances in Digestive Medicine.2022; 9(1): 17. CrossRef
Clinical features of fundic gland polyps and their correlation with colorectal tumors
Xue-Mei Yang, Hong Xu
World Chinese Journal of Digestology.2020; 28(20): 1036. CrossRef
Parietalzellhypertrophie und Drüsenkörperzysten
M. Venerito, A. Canbay, M. Vieth
Der Gastroenterologe.2018; 13(2): 90. CrossRef

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Increased Risk of Asymptomatic Gallstones in Patients With Ulcerative Colitis: Jung Hoon Ha, Young Sook Park, Choon Sik Seon, Byung Kwan Son, Sang Bong Ahn, Young Kwan Jo, Seong Hwan Kim, Yun Ju Jo, Jung Hwan Kim, Jee Hye Han, Yoon Young Jung, Sook Hee Chung; Intest Res 2015;13(2):122-127. Published online April 27, 2015; DOI: https://doi.org/10.5217/ir.2015.13.2.122

Abstract PDF PubReader

Background/Aims

The relationship between Crohn's disease and gallstones is established. However, the prevalence and risk factors for gallstones in patients with ulcerative colitis (UC) are not yet well understood. The aim of this study was to evaluate the prevalence and risk factors of gallstones in patients with UC.

Methods

This study was a retrospective single center study. A total of 87 patients with UC and 261 healthy controls were enrolled. Age, sex, and body mass index were matched. To investigate risk factors, the extent of UC, duration of disease, number of hospital admissions, and number of steroid treatments in patients with UC were evaluated.

Results

The prevalence of gallstones in patients with UC was 13.8%, whereas that in healthy controls was only 3.1% (P<0.001). For patients with UC, patients ≥50 years of age had a 3.6-times higher risk of gallstones compared to that in those <50 years of age, and the difference was statistically significant (odds ratio, 3.60; confidence interval, 1.03-12.61) in univariate analysis. There were no statistically significant disease-related risk factors for gallstones in UC patients.

Conclusions

This is the first study of gallstone prevalence in Korean UC patients. In this study, patients with UC had a higher prevalence of gallstones compared to that in well-matched healthy controls. Age seemed to be a possible risk factor, and more studies are needed. Further prospective, large-scale studies will be required to confirm the risk factors for gallstones in UC patients.

Citations

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Prevalence of Gallstones in Ulcerative Colitis and Crohn’s Disease: A Systematic Review and Meta-Analysis
Mirza M. A Baig, Shayan A Irfan, Anusha Sumbal, Ramish Sumbal, Sanjay Kumar, Junaid Ahmad, Nikhila Gandrakota, Laila Tul Qadar, Maida S Chaudhry, Azka Feroz, Muhammad Sheharyar Warraich
Cureus.2022;[Epub] CrossRef
Comorbidity in children with gallstone disease
S. Yu. Matalaeva, V. A. Shashel
Experimental and Clinical Gastroenterology.2021; 1(1): 89. CrossRef
Gallstone disease in children and comorbiditi
S. Yu. Matalayeva
Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2021; 66(3): 34. CrossRef
Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
International Journal of Environmental Research and Public Health.2018; 15(3): 513. CrossRef
Gallstone prevalence and risk factors in patients with ulcerative colitis in Korean population
Yo Han Jeong, Kyeong Ok Kim, Ho Chan Lee, Se Hoon Sohn, Jung Woo Lee, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Medicine.2017; 96(31): e7653. CrossRef
The Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis
Cong Dai, Min Jiang, Ming-Jun Sun
American Journal of Gastroenterology.2017; 112(7): 1165. CrossRef
Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R. Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz, John Green
PLOS ONE.2017; 12(10): e0185193. CrossRef

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Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study: Young Seok Doh, You Sun Kim, Hye Jin Jung, Young Il Park, Jin Won Mo, Hyun Sung, Kyung Jin Lee, Young Ki Seo, Jeong Seop Moon, Seong Woo Hong; Intest Res 2014;12(4):299-305. Published online October 27, 2014; DOI: https://doi.org/10.5217/ir.2014.12.4.299

Abstract PDF PubReader ePub

Background/Aims

Antibiotic usage and increasingly aging populations have led to increased incidence of Clostridium difficile infection (CDI) in worldwide. Recent studies in Korea have also reported increasing CDI incidence; however, there have been no reports on the long-term outcomes of CDI. We therefore investigated the long-term clinical outcomes of patients with CDI, including delayed recurrence, associated risk factors and mortality.

Methods

Hospitalized patients diagnosed with CDI at Seoul Paik Hospital between January 2007 and December 2008 were included. Their medical records were retrospectively investigated. 'Delayed recurrence' was defined as a relapse 8 weeks after a successful initial treatment. Multivariate logistic regression analysis was performed to identify risk factors for the delayed recurrence. Kaplan-Meier curves were used to analyze mortality rates.

Results

A total of 120 patients were enrolled; among them, 87 were followed-up for at least 1 year, with a mean follow-up period of 34.1±25.1 months. Delayed recurrence was observed in 17 patients (19.5%), and significant risk factors were age (over 70 years, P=0.049), nasogastric tube insertion (P=0.008), and proton pump inhibitor or H₂-blocker treatments (P=0.028). The 12- and 24-month mortality rates were 24.6% and 32.5%, respectively. No deaths were directly attributed to CDI.

Conclusions

Delayed recurrence of CDI was not rare, occurring in 19.5% of the study population. Although CDI-related mortality was not reported, 2-year (32.5%) mortality rate of CDI patients implies that a CDI diagnosis may predict severe morbidity and poor prognosis of the underlying disease.

Citations

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BMC Infectious Diseases.2024;[Epub] CrossRef
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J.E. Baek, I.H. Choi, Y.W. Cho, J. Kim, Y.J. Lee, M.C. Kim, K.O. Kim, Y-S. Cho
Journal of Hospital Infection.2023; 139: 106. CrossRef
Predictive Factors for Death among Patients with Clostridium difficile Infection – A Single Center Experience Study
Vlad A. Ionescu, Camelia C. Diaconu, Raluca S. Costache, Florentina Gheorghe, Andreea G. Andronesi, Gina Gheorghe
Romanian Journal of Military Medicine.2023; 126(4): 492. CrossRef
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Daira Rubio-Mendoza, Adrián Martínez-Meléndez, Héctor Jesús Maldonado-Garza, Carlos Córdova-Fletes, Elvira Garza-González
Microorganisms.2023; 11(10): 2525. CrossRef
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Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Applied Microbiology and Biotechnology.2022; 106(19-20): 6689. CrossRef
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Infection Control & Hospital Epidemiology.2021; 42(5): 549. CrossRef
External validation of two prediction tools for patients at risk for recurrent Clostridioides difficile infection
Tessel M. van Rossen, Laura J. van Dijk, Martijn W. Heymans, Olaf M. Dekkers, Christina M. J. E. Vandenbroucke-Grauls, Yvette H. van Beurden
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RBX7455, a Non-frozen, Orally Administered Investigational Live Biotherapeutic, Is Safe, Effective, and Shifts Patients’ Microbiomes in a Phase 1 Study for Recurrent Clostridioides difficile Infections
Sahil Khanna, Darrell S Pardi, Courtney Jones, William D Shannon, Carlos Gonzalez, Ken Blount
Clinical Infectious Diseases.2021; 73(7): e1613. CrossRef
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Yichun Fu, Yuying Luo, Ari M Grinspan
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Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Parkpoom Phatharacharukul, Wisit Cheungpasitporn
Journal of Evidence-Based Medicine.2018; 11(1): 40. CrossRef
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Pil Hun Song, Jung Hwa Min, You Sun Kim, Soo Yeon Jo, Eun Jin Kim, Kyung Jin Lee, Jeonghun Lee, Hyun Sung, Jeong Seop Moon, Dong Hee Whang
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