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Original Articles
IBD
Sarcopenia is common in ulcerative colitis and correlates with disease activity
Pardhu B Neelam, Rimesh Pal, Pankaj Gupta, Anupam K Singh, Jimil Shah, Harshal S Mandavdhare, Harjeet Singh, Aravind Sekar, Sanjay K Bhadada, Usha Dutta, Vishal Sharma
Intest Res 2024;22(2):162-171.   Published online January 22, 2024
DOI: https://doi.org/10.5217/ir.2023.00090
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background/Aims
Association of sarcopenia with disease severity in ulcerative colitis (UC) is not clearly defined. We planned to estimate the prevalence of sarcopenia in patients with UC as per the revised definition and its relation with the disease severity.
Methods
A cross-sectional assessment of sarcopenia in patients with UC was performed. Disease activity was graded according to complete Mayo score. Hand grip strength was assessed with Jamar hand dynamometer, muscle mass using a dual energy X-ray absorptiometry scan, and physical performance with 4-m walk test. Sarcopenia was defined as a reduction of both muscle mass and strength. Severe sarcopenia was defined as reduced gait speed in presence of sarcopenia.
Results
Of 114 patients (62 males, mean age: 36.49±12.41 years), 32 (28%) were in remission, 46 (40.4%) had mild-moderate activity, and 36 (31.6%) had severe UC. Forty-three patients (37.7%) had probable sarcopenia, 25 (21.9%) had sarcopenia, and 14 (12.2%) had severe sarcopenia. Prevalence of sarcopenia was higher in active disease (2 in remission, 6 in active, and 17 in severe, P<0.001). Of 14 with severe sarcopenia, 13 had severe UC while 1 had moderate UC. On multivariate analysis, lower body mass index and higher Mayo score were associated with sarcopenia. Of 37 patients with acute severe colitis, 16 had sarcopenia. Requirement of second-line therapy was similar between patients with and without sarcopenia. On follow-up (median: 18 months), there was a non-significant higher rate of major adverse events in those with sarcopenia (47.4% vs. 33.8%, P=0.273).
Conclusions
Sarcopenia and severe sarcopenia in UC correlate with the disease activity.

Citations

Citations to this article as recorded by  
  • Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence
    Pardhu B Neelam, Alka Sharma, Vishal Sharma
    JGH Open.2024;[Epub]     CrossRef
  • Utility of SARC‐F for screening for sarcopenia in ulcerative colitis
    Pardhu B. Neelam, Vishal Sharma
    Nutrition in Clinical Practice.2024; 39(5): 1270.     CrossRef
  • Response to “Utility of SARC‐F for screening for sarcopenia in ulcerative colitis”
    Ilkay Ergenc, Chasan Ismail Basa, Alper Uzum, Sevval Sahin, Haluk Tarık Kani, Rahmi Aslan, Aslı Tufan, Özgür Kasımay, Özlen Atuğ, Yeşim Özen Alahdab
    Nutrition in Clinical Practice.2024; 39(5): 1272.     CrossRef
  • 4,038 View
  • 257 Download
  • 3 Web of Science
  • 3 Crossref
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Inflammatory bowel diseases
The prevalence of sarcopenia and its effect on prognosis in patients with Crohn’s disease
Chan Hyung Lee, Hyuk Yoon, Dong Jun Oh, Jae Min Lee, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Intest Res 2020;18(1):79-84.   Published online January 30, 2020
DOI: https://doi.org/10.5217/ir.2019.00107
AbstractAbstract PDFPubReaderePub
Background/Aims
Crohn’s disease is associated with altered body composition, such as low muscle mass, which can affect clinical outcomes. However, there are few studies regarding the effect of sarcopenia on prognosis of Crohn’s disease. In this study, we evaluated the body composition at the initial diagnosis of Crohn’s disease and analyzed the clinical meaning of sarcopenia.
Methods
We conducted a retrospective review of medical records of patients who were diagnosed as Crohn’s disease and underwent computed tomography within 3 months after diagnosis. Sarcopenia was defined as an L3 skeletal muscle index (SMI) of < 49 cm2/m2 for men and < 31 cm2/m2 for women. Outcomes such as need for hospitalization, surgery, use of steroids, immunomodulators and biologics were analyzed.
Results
A total of 79 patients (male, 73.4%; mean age, 29.9 years) were included and 40 patients (51%) were diagnosed as sarcopenia. C-reactive protein (CRP) level was correlated with sarcopenia (P= 0.044). Erythrocyte sedimentation rate (ESR) showed a tendency to decrease inversely with SMI (r = –0.320, P= 0.008) and hemoglobin and albumin tended to increase in proportion to SMI (hemoglobin: r = 0.271, P= 0.016 and albumin: r = 0.350, P= 0.002). However, there was no statistically significance in time-to-first-event analysis in aspects of sarcopenia.
Conclusions
Approximately 50% of patients with newly diagnosed as Crohn’s disease had sarcopenia. CRP levels were higher in the sarcopenia group and SMI correlated with ESR, hemoglobin, and albumin. However, none of prognostic values were demonstrated.

Citations

Citations to this article as recorded by  
  • Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence
    Pardhu B Neelam, Alka Sharma, Vishal Sharma
    JGH Open.2024;[Epub]     CrossRef
  • The association between hemoglobin level and sarcopenia in Chinese patients with Crohn’s disease
    Nandong Hu, Jingjing Liu, Xifa Gao, Hongye Tang, Jiangchuan Wang, Zicheng Wei, Zhongqiu Wang, Xiaoli Yu, Xiao Chen
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Hepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Disease
    Hye Kyung Hyun, Hye Won Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
    Gut and Liver.2024; 18(2): 294.     CrossRef
  • Ultrasound muscle assessment for sarcopenia detection in inflammatory bowel disease: A prospective study
    Giacomo Mulinacci, Lorena Pirola, Davide Gandola, Davide Ippolito, Chiara Viganò, Alice Laffusa, Camilla Gallo, Pietro Invernizzi, Silvio Danese, Sara Massironi
    United European Gastroenterology Journal.2024; 12(5): 562.     CrossRef
  • Causal associations between autoimmune diseases and sarcopenia-related traits: a bi-directional Mendelian randomization study
    Chunlan Chen, Ying He
    Frontiers in Genetics.2024;[Epub]     CrossRef
  • The Relationship Between Intramural Fat Accumulation and Sarcopenia on MR Enterography Exams in Patients with Crohn’s Disease
    Oktay Algin, Yasin Celal Güneş, Rasim Eren Cankurtaran, Seniha Corabay, Oyku Tayfur Yurekli
    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.2024;[Epub]     CrossRef
  • The relationship between inflammatory bowel disease and sarcopenia-related traits: a bidirectional two-sample mendelian randomization study
    Zhihuang Sun, Guangwei Liu, Jiajia Xu, Xianyu Zhang, Huahua Wei, Guobao Wu, Jian Jiang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Association between sarcopenia and hemoglobin level: a systematic review and meta-analysis
    Hui Wang, Ping Lin
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Impact of Sarcopenia on Clinical Course of Inflammatory Bowel Disease in Korea
    Kwangwoo Nam, Jae Yong Lee, Yousun Ko, Kyung Won Kim, Ho-Su Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byoun, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
    Digestive Diseases and Sciences.2023; 68(6): 2165.     CrossRef
  • Nutritional Risk and Sarcopenia Features in Patients with Crohn’s Disease: Relation to Body Composition, Physical Performance, Nutritional Questionnaires and Biomarkers
    Konstantinos Papadimitriou, Paraskevi Detopoulou, Konstantinos Soufleris, Gavriela Voulgaridou, Despoina Tsoumana, Panagiotis Ntopromireskou, Constantinos Giaginis, Ioanna P. Chatziprodromidou, Maria Spanoudaki, Sousana K. Papadopoulou
    Nutrients.2023; 15(16): 3615.     CrossRef
  • Two-year real-world outcome data from a single tertiary centre shows reduced ustekinumab persistence in a non-bio-naïve Crohn’s disease cohort with penetrating disease, -ostomies and sarcopenia
    Saskia Inniss, Konstantinos C. Fragkos, Lisa Whitley, Rachel Wimpory, Eleanor Rebello, Ana Lisboa, Tanvi Khetan, Jasmine Hassan, Kate Simpson, Anisha Bhagwanani, Roser Vega, Ioanna Parisi, Paul Harrow, Edward Seward, Sara McCartney, Stuart Bloom, Andrew M
    Therapeutic Advances in Chronic Disease.2023;[Epub]     CrossRef
  • Sarcopenia is a negative predictive factor for endoscopic remission in patients with Crohn's disease treated with biologics
    Mauro Grova, Federica Crispino, Marcello Maida, Alessandro Vitello, Sara Renna, Angelo Casà, Lorenzo Tesè, Fabio Salvatore Macaluso, Ambrogio Orlando
    Digestive and Liver Disease.2023; 55(7): 865.     CrossRef
  • The effect of biological agent on body composition in patients with Crohn’s disease
    Eun Jeong Choi, Dong Hoon Baek, Hong Sub Lee, Geun Am Song, Tae Oh Kim, Yong Eun Park, Chang Min Lee, Jong Hoon Lee
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Review article: Putting some muscle into sarcopenia—the pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease
    Stephanie L. Gold, Maitreyi Raman, Bruce E. Sands, Ryan Ungaro, João Sabino
    Alimentary Pharmacology & Therapeutics.2023; 57(11): 1216.     CrossRef
  • Association between computed tomography‐assessed sarcopenia and mortality in patients with anti‐neutrophil cytoplasmic antibody‐associated vasculitis
    Sung Soo Ahn, Yong‐Beom Park, Sang‐Won Lee
    International Journal of Rheumatic Diseases.2023; 26(9): 1704.     CrossRef
  • Imaging-based assessment of body composition in patients with Crohn’s disease: a systematic review
    Wuli Tang, Gang Xie, Danni Wang, Ting Li, Yitao Ren, Junlin Li, Jiaxing Deng, Kang Li
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Systematic review of sarcopenia in inflammatory bowel disease
    Hala Fatani, Adina Olaru, Rebecca Stevenson, Waad Alharazi, Ayman Jafer, Philip Atherton, Matthew Brook, Gordon Moran
    Clinical Nutrition.2023; 42(8): 1276.     CrossRef
  • Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease
    Marco Valvano, Annalisa Capannolo, Nicola Cesaro, Gianpiero Stefanelli, Stefano Fabiani, Sara Frassino, Sabrina Monaco, Marco Magistroni, Angelo Viscido, Giovanni Latella
    Nutrients.2023; 15(17): 3824.     CrossRef
  • Magnetic Resonance Imaging Can Be Used to Assess Sarcopenia in Children with Newly Diagnosed Crohn’s Disease
    Paola Blagec, Sila Sara, Ana Tripalo Batoš, Ivana Trivić Mažuranić, Ana Močić Pavić, Zrinjka Mišak, Iva Hojsak
    Nutrients.2023; 15(17): 3838.     CrossRef
  • Key genes of inflammation and Crohn’s disease severity identified via bioinformatics and clinical specimen analysis
    Min Lu, Zhirui Zeng, Yongjian Ling, Qinsong Zhong, Zhiliang Mai, Hua Mao, Qian Wang
    All Life.2023;[Epub]     CrossRef
  • Research progress on the predictive role of sarcopenia in the course and prognosis of inflammatory bowel disease
    Yang Liu, Linglin Tian
    PeerJ.2023; 11: e16421.     CrossRef
  • Characteristics of malnutrition according to Global Leadership Initiative on Malnutrition criteria in non-surgical patients with inflammatory bowel disease
    Shanshan Huang, Yang Niu, Xiaowei Liu, Zhengye Gu, Aiyue Huang, Jiang Wu
    Nutrition.2022; 94: 111514.     CrossRef
  • Nutritional screening and assessment in inflammatory bowel disease
    Arshdeep Singh, Catherine Wall, Arie Levine, Vandana Midha, Ramit Mahajan, Ajit Sood
    Indian Journal of Gastroenterology.2022; 41(1): 5.     CrossRef
  • Association Between Frailty or Sarcopenia and Adverse Outcomes in Inflammatory Bowel Disease: A Systematic Review
    Katherine Bedard, Naheed Rajabali, Puneeta Tandon, Juan G. Abraldes, Farhad Peerani
    Gastro Hep Advances.2022; 1(2): 241.     CrossRef
  • Sarcopenia Is More Prevalent Among Inflammatory Bowel Disease Patients Undergoing Surgery and Predicts Progression to Surgery Among Medically Treated Patients
    James P Campbell, Levi Teigen, Scott Manski, Brian Blumhof, Flavius F Guglielmo, Raina Shivashankar, Eugenia Shmidt
    Inflammatory Bowel Diseases.2022; 28(12): 1844.     CrossRef
  • Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus
    Ashwin N Ananthakrishnan, Gilaad G Kaplan, Charles N Bernstein, Kristin E Burke, Paul J Lochhead, Alexa N Sasson, Manasi Agrawal, Jimmy Ho Tuan Tiong, Joshua Steinberg, Wolfgang Kruis, Flavio Steinwurz, Vineet Ahuja, Siew C Ng, David T Rubin, Jean-Frederi
    The Lancet Gastroenterology & Hepatology.2022; 7(7): 666.     CrossRef
  • Sarcopenia in Inflammatory Bowel Diseases: Reviewing Past Work to Pave the Path for the Future
    Adam S. Faye, Tasnin Khan, Sandhya Cautha, Bharati Kochar
    Current Treatment Options in Gastroenterology.2022; 20(3): 250.     CrossRef
  • Personalized medicine in inflammatory bowel disease: Perspectives on Asia
    Su Hyun Park, Sang Hyoung Park
    Journal of Gastroenterology and Hepatology.2022; 37(8): 1434.     CrossRef
  • Hematopoietic Stem Cell Transplantation in Refractory Crohn’s Disease: Should It Be Considered?
    Simon Reider, Lukas Binder, Stefan Fürst, Stefan Hatzl, Andreas Blesl
    Cells.2022; 11(21): 3463.     CrossRef
  • Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease
    Ji Young Lee, Kyung Won Kim, Yousun Ko, Chi Hyuk Oh, Bo Hyun Kim, Seong Jin Park, Myung-Won You
    Diagnostics.2022; 12(11): 2804.     CrossRef
  • Low psoas muscle area is associated with postoperative complications in Crohn’s disease
    Yaniv Zager, Saed Khalilieh, Omar Ganaiem, Eli Gorgov, Nir Horesh, Roi Anteby, Uri Kopylov, Harel Jacoby, Yael Dreznik, Assaf Dori, Mordechai Gutman, Avinoam Nevler
    International Journal of Colorectal Disease.2021; 36(3): 543.     CrossRef
  • Combination of sarcopenia and high visceral fat predict poor outcomes in patients with Crohn’s disease
    Gurasis Boparai, Saurabh Kedia, Devasenathipathy Kandasamy, Raju Sharma, Kumble Seetharama Madhusudhan, Nihar Ranjan Dash, Pabitra Sahu, Sujoy Pal, Peush Sahni, Rajesh Panwar, Sudheer Kumar Vuyyuru, Bhaskar Kante, Davesh P. Yadav, Venigalla Pratap Mouli,
    European Journal of Clinical Nutrition.2021; 75(10): 1491.     CrossRef
  • Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview
    Amritpal Dhaliwal, Jonathan I. Quinlan, Kellie Overthrow, Carolyn Greig, Janet M. Lord, Matthew J. Armstrong, Sheldon C. Cooper
    Nutrients.2021; 13(2): 656.     CrossRef
  • Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together
    Francesco Palmese, Rossella Del Toro, Giulia Di Marzio, Pierluigi Cataleta, Maria Giulia Sama, Marco Domenicali
    Nutrients.2021; 13(4): 1378.     CrossRef
  • Pathogenesis of Musculoskeletal Deficits in Children and Adults with Inflammatory Bowel Disease
    Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
    Nutrients.2021; 13(8): 2899.     CrossRef
  • Inflammatory Bowel Disease and Sarcopenia: Its Mechanism and Clinical Importance
    Hiroki Nishikawa, Shiro Nakamura, Takako Miyazaki, Kazuki Kakimoto, Shinya Fukunishi, Akira Asai, Shuhei Nishiguchi, Kazuhide Higuchi
    Journal of Clinical Medicine.2021; 10(18): 4214.     CrossRef
  • Myostatin and Follistatin—New Kids on the Block in the Diagnosis of Sarcopenia in IBD and Possible Therapeutic Implications
    Dorota Skrzypczak, Marzena Skrzypczak-Zielińska, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Piotr Eder, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
    Biomedicines.2021; 9(10): 1301.     CrossRef
  • Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission
    Lisa Dowling, Philip Jakeman, Catherine Norton, Maeve M. Skelly, Hamid Yousuf, Miranda G. Kiernan, Margaret Toomey, Sheila Bowers, Suzanne S. Dunne, J. Calvin Coffey, Colum P. Dunne
    Scientific Reports.2021;[Epub]     CrossRef
  • What Determines Good Rehabilitation Recovery in Stroke Patients with very Severe Disability? A Retrospective Cohort Study
    Shengjie Zhao, Tong Zhang, Bingjie Li, Zhangwei Wu, Jun Zhao
    Journal of Stroke and Cerebrovascular Diseases.2020; 29(10): 105130.     CrossRef
  • Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review
    Hyo Jin An, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Keum Hwa Lee, Seoung Wan Nam, Jae Seok Kim, Jae Won Yang, Jun Young Lee, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Jae Il Shin, Andreas Kronbichler
    International Journal of Molecular Sciences.2020; 21(16): 5678.     CrossRef
  • Diagnosis of malnutrition in patients with gastrointestinal diseases: recent observations from a Global Leadership Initiative on Malnutrition perspective
    Tommy Cederholm, Zeljko Krznaric, Matthias Pirlich
    Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(5): 361.     CrossRef
  • Incorporating Frailty in the Treatment Program of Elderly Patients with Gastrointestinal Disease
    C. Thompson, S. Taleban
    Current Treatment Options in Gastroenterology.2020; 18(4): 635.     CrossRef
  • 8,819 View
  • 218 Download
  • 40 Web of Science
  • 42 Crossref
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