Skip Navigation
Skip to contents

Intest Res : Intestinal Research

IMPACT FACTOR

Search

Page Path
HOME > Search
1 "Silent Crohn’s disease"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review
Inflammatory bowel diseases
Clinical management for small bowel of Crohn’s disease in the treat-to-target era: now is the time to optimize treatment based on the dominant lesion
Kenji Watanabe
Intest Res 2020;18(4):347-354.   Published online October 26, 2020
DOI: https://doi.org/10.5217/ir.2020.00032
AbstractAbstract PDFPubReaderePub
A treat-to-target strategy, in which treatment is continuously adjusted according to the results of scheduled objective monitoring, is optimal for patients with Crohn’s disease (CD) in the era of biologics. The small bowel is a common site of intractable CD, which may result from multiple strictures or expanding lesions. To improve the prognosis of patients with small bowel CD, lesions should be proactively monitored within the subclinical phase. Objective assessment of small bowel lesions is technically difficult, however, due to the relatively poor correlation between endoscopic activity and clinical symptoms or biomarker titers. The presence of proximal small bowel lesions and asymptomatic “Real Silent CD” must be considered. Endoscopy remains the gold standard to assess these lesions. In clinical practice, the advantages and disadvantages of each imaging modality and biomarker must be carefully weighed for appropriate application and reliable monitoring. The prevalence of small bowel lesions depends on the precision of the imaging modality used for detection. Clinical management should be based on the dominant location of the intestinal lesions rather than classical classification. Optimal strategies for detecting and treating small bowel lesions in patients with CD must be developed utilizing reliable, precise, and objective monitoring.

Citations

Citations to this article as recorded by  
  • Outcomes of Patients With Prior Biologic Intolerance Are Better Than Those With Biologic Failure in Clinical Trials of Inflammatory Bowel Disease
    Sunil Samnani, Emily C L Wong, Hasan Hamam, Parambir S Dulai, John K Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
    Journal of Crohn's and Colitis.2025;[Epub]     CrossRef
  • Intestinal ultrasound accurately predicts future therapy failure in Crohn’s disease patients in a biologics-induced remission
    Ahmad Albshesh, Alon Abend, Reuma Margalit Yehuda, Hussein Mahajna, Bella Ungar, Shomron Ben-Horin, Uri Kopylov, Dan Carter
    European Journal of Gastroenterology & Hepatology.2025; 37(2): 184.     CrossRef
  • Small bowel vasculitis? what a gastroenterologist should know - from diagnosis to management
    João Carlos Gonçalves, Bruno Rosa, José Cotter
    Current Opinion in Gastroenterology.2025; 41(3): 132.     CrossRef
  • Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn’s disease
    Masashi Ohno, Atsushi Nishida, Akinori Otsuki, Yoshihiro Yokota, Takayuki Imai, Shigeki Bamba, Osamu Inatomi
    World Journal of Gastrointestinal Endoscopy.2025;[Epub]     CrossRef
  • Guidelines for endoscopic diagnosis and treatment of inflammatory bowel diseases
    Takayuki Matsumoto, Tadakazu Hisamatsu, Motohiro Esaki, Teppei Omori, Hirotake Sakuraba, Shinichiro Shinzaki, Ken Sugimoto, Kento Takenaka, Makoto Naganuma, Shigeki Bamba, Takashi Hisabe, Sakiko Hiraoka, Mikihiro Fujiya, Minoru Matsuura, Shunichi Yanai, K
    Digestive Endoscopy.2025; 37(4): 319.     CrossRef
  • Role of noncontrast enhanced abdominal ultrasound in the diagnostic assessment of pediatric inflammatory bowel disease
    Katie Ritchie, Angharad Vernon‐Roberts, Andrew S. Day
    Journal of Pediatric Gastroenterology and Nutrition.2025; 80(6): 979.     CrossRef
  • Comparison of an Endoscopic Scoring System and the Simplified Magnetic Resonance Index of Activity in Patients with Small Bowel Crohn’s Disease
    Ji Eun Na, Hon Soul Kim, Sung Noh Hong, Kyoung Doo Song, Ji Eun Kim, Eun Ran Kim, Young-Ho Kim, Dong Kyung Chang
    Gut and Liver.2024; 18(1): 97.     CrossRef
  • Use of double-balloon endoscopy and an endoscopic scoring system to assess endoscopic remission in isolated small bowel Crohn’s disease after treatment with infliximab
    Wei Han, Jing Hu, Juan Wu, Peipei Zhang, Qiuyuan Liu, Naizhong Hu, Qiao Mei
    Therapeutic Advances in Gastroenterology.2024;[Epub]     CrossRef
  • Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
    Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
    Intestinal Research.2023; 21(1): 148.     CrossRef
  • Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
    Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
    Gut and Liver.2023; 17(4): 581.     CrossRef
  • Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
    Da-Yeon Kang, Jong-Lyul Park, Min-Kyung Yeo, Sang-Bum Kang, Jin-Man Kim, Ju Seok Kim, Seon-Young Kim
    BMC Microbiology.2023;[Epub]     CrossRef
  • Combined Endoscopic and Radiologic Healing Is Associated With a Better Prognosis Than Endoscopic Healing Only in Patients With Crohn's Disease Receiving Anti-TNF Therapy
    Kyunghwan Oh, Eun Hye Oh, Soo Min Noh, Seong Ho Park, Nayoung Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Clinical and Translational Gastroenterology.2022; 13(1): e00442.     CrossRef
  • Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study
    Jihye Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Alaa El-Hussuna
    PLOS ONE.2022; 17(1): e0262571.     CrossRef
  • Long-term Disease Course of Crohn’s Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors
    Choong Wui Cho, Myung-Won You, Chi Hyuk Oh, Chang Kyun Lee, Sung Kyoung Moon
    Gut and Liver.2022; 16(2): 157.     CrossRef
  • Comparative effectiveness of second-line biological therapies for ulcerative colitis and Crohn’s disease in patients with prior failure of anti-tumour necrosis factor treatment
    Hye Kyung Hyun, Hyun-Soo Zhang, Jongwook Yu, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Is radiological healing alone enough? ‘Can’t take my eyes off’ the mucosa
    Su Hyun Park, Sang Hyoung Park
    The Korean Journal of Internal Medicine.2022; 37(3): 551.     CrossRef
  • Fecal S100A12 is associated with future hospitalization and step-up of medical treatment in patients with Crohn’s disease in clinical remission: a pilot study
    Sun-Ho Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
    Intestinal Research.2022; 20(2): 203.     CrossRef
  • Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn’s Disease Recurrence
    Jongwook Yu, Hye Kyung Hyun, Jihye Park, Eun Ae Kang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
    Gut and Liver.2022; 16(3): 414.     CrossRef
  • Intestinal ultrasonography and fecal calprotectin for monitoring inflammation of ileal Crohn’s disease: two complementary tests
    José María Paredes, Tomás Ripollés, Ángela Algarra, Rafael Diaz, Nadia Moreno, Patricia Latorre, María Jesús Martínez, Pilar Llopis, Antonio López, Eduardo Moreno-Osset
    Intestinal Research.2022; 20(3): 361.     CrossRef
  • Radiation Exposure among Patients with Inflammatory Bowel Disease: A Single-Medical-Center Retrospective Analysis in Taiwan
    Chen-Ta Yang, Hsu-Heng Yen, Yang-Yuan Chen, Pei-Yuan Su, Siou-Ping Huang
    Journal of Clinical Medicine.2022; 11(17): 5050.     CrossRef
  • Capsule endoscopy in Crohn's disease surveillance: A monocentric, retrospective analysis in Italy
    Carlo Calabrese, Dania Gelli, Fernando Rizzello, Paolo Gionchetti, Rafael Torrejon Torres, Rhodri Saunders, Jason Davis
    Frontiers in Medical Technology.2022;[Epub]     CrossRef
  • Risk factors and prognostic value of acute severe lower gastrointestinal bleeding in Crohn’s disease
    Jiyoung Yoon, Dae Sung Kim, Ye-Jee Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
    World Journal of Gastroenterology.2021; 27(19): 2353.     CrossRef
  • Is Paradigm for the Role of Balloon-Assisted Enteroscopy Changing in Crohn’s Disease?
    Yoo Jin Lee
    Gut and Liver.2021; 15(3): 325.     CrossRef
  • Epithelial Regeneration Ability of Crohn’s Disease Assessed Using Patient-Derived Intestinal Organoids
    Chansu Lee, Sung-Noh Hong, Eun-Ran Kim, Dong-Kyung Chang, Young-Ho Kim
    International Journal of Molecular Sciences.2021; 22(11): 6013.     CrossRef
  • Editorial: higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease
    Shana Rakowsky, Adam S. Cheifetz, Konstantinos Papamichael
    Alimentary Pharmacology & Therapeutics.2021; 54(8): 1085.     CrossRef
  • Another Piece of Evidence for Early Administration of Biologics in Children with Crohn's Disease Who Start as an Inflammatory Phenotype
    Hyuk Yoon
    Gut and Liver.2021; 15(6): 791.     CrossRef
  • Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?
    Soo-Young Na, Yun-Jeong Lim
    Diagnostics.2021; 11(12): 2240.     CrossRef
  • 8,969 View
  • 238 Download
  • 27 Web of Science
  • 27 Crossref
Close layer

Intest Res : Intestinal Research
Close layer
TOP