Intestinal Research

Review

IBD

Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?: Emiko Mizoguchi, Takayuki Sadanaga, Toshiyuki Okada, Takanori Minagawa, Jun Akiba; Intest Res 2023;21(3):306-317. Published online April 20, 2023; DOI: https://doi.org/10.5217/ir.2022.00118

Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates, and so on. Our group previously reported that oral administration of CAF efficiently suppressed the development of intestinal inflammation in a dextran sulfate sodium (DSS)-induced murine acute colitis model by suppressing the expression of chitinase 3-like 1, one of the mammalian chitinases without enzymatic activity. Chitinases are hydrolytic enzymes that break down chitin, a polymer of N-acetylglucosamine, and chitinase-like proteins have no enzymatic activity with preserving chitin-binding ability. CAF binds a cleft of the chitinase active site and plays a role as a pan-chitinase inhibitor. Although CAF showed an anti-inflammatory effect in the above model, oral administration of low-dose CAF with 10% sucrose showed potentially neoplastic effects in colonic epithelial cells in a DSS-induced murine chronic colitis model. In this review, we would like to discuss the pros and cons of coffee/CAF in colonic inflammation and neoplasia with an example of pathological finding.

Citations

Citations to this article as recorded by

Strategies for enhancing sustainable and economic utilization of almond waste through a comprehensive multi-stage systematic approach to pathogen control
Manjula Nishantha Udagepolage Don, Singarayer Florentine, Chris Turville, Kithsiri Dassanayake
Journal of Natural Pesticide Research.2025; 12: 100126. CrossRef
Caffeine modulates immunoproteasome activity and content in colorectal adenocarcinoma cells
Alexander Burov, Alexander Rezvykh, Valeria Vedernikova, Alexey Belogurov, Vladimir Prassolov, Pavel Spirin, Sergey Funikov, Alexey Morozov, Vadim Karpov
Biochimie.2025;[Epub] CrossRef
Evaluation of the effect of roasting and digestion on biological activity of compounds of coffee extracts - in vitro assessment of the bioavailability, cytoprotective properties and modulation of inflammatory response
Joanna Grzelczyk, Grażyna Budryn, Dominik Szwajgier, Ewa Baranowska-Wójcik, Małgorzata Zakłos-Szyda
Food Chemistry.2024; 460: 140648. CrossRef
Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation
Emiko Mizoguchi, Takayuki Sadanaga, Linda Nanni, Siyuan Wang, Atsushi Mizoguchi
Cells.2024; 13(8): 678. CrossRef
Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo
Yu Rim Kim, Soo-yeon Park, Ji Yeon Kim
Journal of Functional Foods.2024; 123: 106563. CrossRef
Dose–Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies
Yuanyuan Dong, Darren Greenwood, James Webster, Chinwe Uzokwe, Jinhui Tao, Laura Hardie, Janet Cade
Nutrients.2024; 16(23): 4050. CrossRef

6,270 View
252 Download
5 Web of Science
6 Crossref

First
Prev
Page of 1
Next
Last

Search