Intestinal Research

Original Articles

IBD

Intestinal ultrasound for intestinal Behçet disease reflects endoscopic activity and histopathological findings: Katsuki Yaguchi, Reiko Kunisaki, Sho Sato, Kaori Hirai, Misato Izumi, Yoshimi Fukuno, Mami Tanaka, Mai Okazaki, Rongrong Wu, Yurika Nishikawa, Yusuke Matsune, Shunsuke Shibui, Yoshinori Nakamori, Masafumi Nishio, Mao Matsubayashi, Tsuyoshi Ogashiwa, Ayako Fujii, Kenichiro Toritani, Hideaki Kimura, Eita Kumagai, Yukiko Sasahara, Yoshiaki Inayama, Satoshi Fujii, Toshiaki Ebina, Kazushi Numata, Shin Maeda; Intest Res 2024;22(3):297-309. Published online July 16, 2024; DOI: https://doi.org/10.5217/ir.2023.00129

Background/Aims
Intestinal Behçet disease is typically associated with ileocecal punched-out ulcers and significant morbidity and mortality. Intestinal ultrasound is a noninvasive imaging technique for disease monitoring. However, no previous reports have compared intestinal ultrasound with endoscopic ulcer activity or histopathological findings for intestinal Behçet disease. We evaluated the usefulness of intestinal ultrasound for assessing the activity of ileocecal ulcers in intestinal Behçet disease.
Methods
We retrospectively compared intestinal ultrasound findings with 73 corresponding endoscopic images and 6 resected specimens. The intestinal ultrasound findings were assessed for 7 parameters (bowel wall thickness, vascularity [evaluated using the modified Limberg score with color Doppler], bowel wall stratification, white-plaque sign [strong hyperechogenic lines or spots], mesenteric lymphadenopathy, extramural phlegmons, and fistulas), and endoscopic ulcer activity was classified into active, healing, and scar stages. Histopathological findings were evaluated by consensus among experienced pathologists.
Results
Bowel wall thickness (P< 0.001), vascularity (P< 0.001), loss of bowel wall stratification (P= 0.015), and white-plague sign (P= 0.013) were significantly exacerbated in the endoscopic active ulcer stage. Receiver operating characteristic curve analysis revealed that a bowel wall thickness of > 5.5 mm (sensitivity 89.7%, specificity 85.3%) was potentially useful for detecting active lesions. When compared with histopathological findings, an increase in bowel wall thickness reflected the ulcer marginal ridge, and the white-plaque sign reflected the ulcer bottom.
Conclusions
Intestinal ultrasound is useful for monitoring intestinal ulcer activity in intestinal Behçet disease.

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Development and validation of a novel intestinal ultrasound score for predicting endoscopic activity of ileocecal ulcers in intestinal Behçet's disease
Katsuki Yaguchi, Reiko Kunisaki, Sho Sato, Serina Haruyama, Kazuki Kurimura, Yoshinori Nakamori, Masafumi Nishio, Kenichiro Toritani, Rongrong Wu, Hideaki Kimura, Toshiaki Ebina, Kazushi Numata, Shin Maeda
Journal of Gastroenterology.2026;[Epub] CrossRef
Elevated IL-6 levels in the intestinal mucosa of patients with gastrointestinal Behçet’s disease
Jihye Park, Arjun Ravi, Katharina Bruzelius, I Seul Park, Philippe Pinton, Jae Hee Cheon
Intestinal Research.2025; 23(4): 559. CrossRef

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IBD

Effectiveness of transabdominal ultrasonography in predicting clinical relapse of Crohn’s disease: Shinya Fukushima, Takehiko Katsurada, Mutsumi Nishida, Satomi Omotehara, Kensuke Sakurai, Kana Yamanashi, Reizo Onishi, Naoya Sakamoto; Intest Res 2024;22(1):82-91. Published online January 29, 2024; DOI: https://doi.org/10.5217/ir.2023.00093

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Background/Aims
Transabdominal ultrasonography (US) helps evaluate Crohn’s disease (CD) activity. We investigated whether the US could predict subsequent adverse outcomes for patients with CD in clinical remission.
Methods
This single-center retrospective study included patients with CD in clinical remission who underwent US between April 2011 and April 2021, focusing on the predictability of subsequent adverse outcomes within 5 years. We used the US-CD, which was calculated using multiple US findings. Predictive variables were assessed using Cox proportional hazards regression analysis, and the predictive value was evaluated using receiver operating characteristic curves.
Results
Seventy-three patients were included. During a median follow-up of 1,441 days (range, 41–1,825 days), 16.4% (12/73) experienced clinical relapse, 9.6% (7/73) required endoscopic balloon dilation (EBD), 58.9% (43/73) required enhanced treatment, and 20.5% (15/73) underwent surgery. In the multivariate analysis, US-CD was significantly associated with clinical relapse (P= 0.038) and the need for enhanced treatment (P= 0.005). The area under the receiver operating characteristic curve for predicting clinical relapse and the need for EBD was 0.77 and 0.81, respectively, with US-CD (cutoff value = 11), and that for requiring enhanced treatment was 0.74 with US-CD (cutoff value = 6). Patients with US-CD ≥ 11 demonstrated a significantly higher occurrence of clinical relapse (P= 0.001) and EBD (P= 0.002) within 5 years. Patients with US-CD ≥ 6 experienced a significantly higher likelihood of requiring enhanced treatment (P< 0.001) within 5 years.
Conclusions
High US-CD is associated with subsequent adverse outcomes in patients with CD.

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Non-invasive monitoring of inflammatory bowel disease using intestinal ultrasound
Hakima Abid, Hajar Cherkaoui, Fatima Benahsine, Asmae Lamine, Maria Lahlali, Ismail Chaouche, Fatima Bartal, Nada Lahmidani, Amine Elmekkaoui, Dafr Allah Benajah, Mohammed Abkari, Sidi Adil Ibrahimi, Karima Elghazi, Mustapha Maaroufi, Mounia Elyousfi
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef
Intestinal ultrasound in Crohn’s disease: A systematic review of its role in diagnosis, monitoring, and treatment response
Partha Pal, Mohammad Abdul Mateen, Kanapuram Pooja, Nandhakumar Rajadurai, Rajesh Gupta, Manu Tandan, Nageshwar Reddy Duvvuru
World Journal of Meta-Analysis.2025;[Epub] CrossRef
ECCO-ESGAR-ESP-IBUS Guideline on Diagnostics and Monitoring of Patients with Inflammatory Bowel Disease: Part 1
Torsten Kucharzik, Stuart Taylor, Mariangela Allocca, Johan Burisch, Pierre Ellul, Marietta Iacucci, Christian Maaser, Pamela Baldin, Gauraang Bhatnagar, Shomron Ben-Horin, Dominik Bettenworth, Mallory Chavannes, Ann Driessen, Emma Flanagan, Frederica Fur
Journal of Crohn's and Colitis.2025;[Epub] CrossRef

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IBD

Submucosal fat accumulation in Crohn’s disease: evaluation with sonography: Tomás Ripollés, María Jesús Martínez-Pérez, José María Paredes, José Vizuete, Gregorio Martin, Lidia Navarro; Intest Res 2023;21(3):385-391. Published online March 17, 2023; DOI: https://doi.org/10.5217/ir.2022.00030

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Background/Aims
The study objective is to investigate the ultrasound features that allow suspecting the presence of submucosal fat deposition, called the fat halo sign (FHS), in the intestinal wall of patients with Crohn’s disease.
Methods
Computed tomography (CT) examinations over a period of 10 years were reviewed for the presence of the FHS in the bowel wall. A measurement of less than –10 Hounsfield units was regarded as indicative of fat. We included only patients who had undergone ultrasound examinations 3 months before or after CT. The study cohort group comprised 68 patients. Wall and submucosal thickness were measured on longitudinal ultrasound sections. A receiver operating characteristic curve was constructed to determine the best cutoff of ultrasound submucosal wall thickness value for predicting FHS in the bowel wall determined on CT.
Results
The FHS was present in 22 patients (31%) on CT. There were significant differences between submucosal thickness of patients with FHS and patients without FHS (4.19 mm vs. 2.41 mm). From the receiver operating characteristic curve, a threshold value of 3.1 mm of submucosal thickness had the best sensitivity and specificity to suspect FHS (95.5% and 89.1%, respectively; area under the curve, 0.962), with an odds ratio of 172. All of 16 patients with a submucosal thickness >3.9 mm had FHS.
Conclusions
FHS in patients with Crohn’s disease can be suspected on ultrasound in cases with marked thickening of the submucosa layer. In these cases, the activity of the disease should be measured by other parameters such as the color Doppler.

Citations

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Ulcerative colitis: moving beyond the mucosal dogma
Elisabeth Eggermont, Krisztina Gecse, Noa Krugliak Cleveland, Frauke Petersen, João Sabino, André D'Hoore, Torsten Kucharzik, Mariangela Allocca, Gabriele Bislenghi, Kerri Novak, Gert De Hertogh, Christian Maaser, Bram Verstockt
The Lancet Gastroenterology & Hepatology.2026; 11(2): 163. CrossRef
Metabolic Disorders and Inflammatory Bowel Diseases
Hye Kyung Hyun, Jae Hee Cheon
Gut and Liver.2025; 19(3): 307. CrossRef
Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis
Maarten J Pruijt, E Andra Neefjes-Borst, Floris A E De Voogd, Marilyne M Lange, Christoph Teichert, Reimer J Janssen, Geert R D’Haens, Krisztina B Gecse
Journal of Crohn’s and Colitis.2025;[Epub] CrossRef
A novel serum biomarker of endoscopic mucosal healing in inflammatory bowel disease
Hyoun Woo Kang
Intestinal Research.2024; 22(1): 3. CrossRef
Role of Intestinal Ultrasound for IBD Care: A Practical Approach
Joerg C. Hoffmann, Tobias Ungewitter
Diagnostics.2024; 14(15): 1639. CrossRef

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Miscellaneous

Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis: Kensuke Sakurai, Takehiko Katsurada, Mutsumi Nishida, Satomi Omotehara, Shinya Fukushima, Shinsuke Otagiri, Kazunori Nagashima, Reizo Onishi, Ryo Takagi, Yoshito Komatsu, Naoya Sakamoto; Intest Res 2023;21(1):126-136. Published online July 22, 2022; DOI: https://doi.org/10.5217/ir.2021.00166

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Background/Aims
The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis.
Methods
We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CTCAE) grade version 5.
Results
Fourteen patients with IMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r=0.687, p=0.009) and CTCAE grade (r=0.628, p=0.035). Bowel wall thickness and UCEIS (r=0.628, p=0.020), as well as color Doppler signal grade and CTCAE grade (r=0.724, p=0.008), were significantly correlated.
Conclusions
US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of IMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.

Citations

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Symptomatic and Sonographic Improvement of Immune Checkpoint Inhibitor Enterocolitis With Risankizumab
Rena Mei, Emily Pepe, David Y Oh, Katy K Tsai, Rishika Chugh, Michael G Kattah
Inflammatory Bowel Diseases.2025; 31(4): 1182. CrossRef
Response
Malek Shatila, Yinghong Wang
Gastrointestinal Endoscopy.2024; 100(2): 349. CrossRef
Ultrasound's echo in the endoscopic realm: navigating checkpoint colitis
Steven Nicolaides, Zaid Ardalan, Alex Boussioutas
Gastrointestinal Endoscopy.2024; 100(2): 349. CrossRef
Systematic review of immune checkpoint inhibitor-related gastrointestinal, hepatobiliary, and pancreatic adverse events
Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bre
Journal for ImmunoTherapy of Cancer.2024; 12(11): e009742. CrossRef
Endoscopic findings of immune checkpoint inhibitor-related gastrointestinal adverse events
Min Kyu Kim, Sung Wook Hwang
Clinical Endoscopy.2024; 57(6): 725. CrossRef
Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review
Sung Wook Hwang, Min Kyu Kim, Mi-Na Kweon
Intestinal Research.2023; 21(4): 433. CrossRef

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IBD

Intestinal ultrasonography and fecal calprotectin for monitoring inflammation of ileal Crohn’s disease: two complementary tests: José María Paredes, Tomás Ripollés, Ángela Algarra, Rafael Diaz, Nadia Moreno, Patricia Latorre, María Jesús Martínez, Pilar Llopis, Antonio López, Eduardo Moreno-Osset; Intest Res 2022;20(3):361-369. Published online March 15, 2022; DOI: https://doi.org/10.5217/ir.2021.00126

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Background/Aims
Tight control of inflammation and adjustment of treatment if activity persists is the current strategy for the management of Crohn’s disease (CD). The usefulness of fecal calprotectin (FC) in isolated involvement of the small intestine in CD is controversial. To assess the usefulness of FC to determine the inflammatory activity detected by intestinal ultrasonography (IUS) in ileal CD.
Methods
Patients with exclusively ileal involvement CD who underwent IUS and an FC were prospectively included. Simple ultrasound index was used to determine inflammatory activity. The usual statistical tests for comparison of diagnostic techniques were used.
Results
One hundred and five patients were included, IUS showed inflammatory activity in 59% of patients and complications in 18.1%. FC showed a significant correlation with IUS in the weak range (Spearman coefficient r=0.502; P<0.001); the area under the receiver operating characteristic curve was 0.79 (95% confidence interval, 0.70–0.88; P<0.001). The FC value that best reflected the activity in IUS was 100 μg/g with sensitivity, specificity, and positive and negative predictive values of 73.0%, 71.4%, 79.3% and 63.8%, respectively. There were no differences in FC concentration between patients with or without transmural complications. The addition of serum C-reactive protein to FC did not improve the ability to assess IUS activity.
Conclusions
FC has a significant correlation with IUS to monitor ileal CD activity. This correlation is weak and it does not allow assessing the presence of CD complications. Both tests should be used in conjunction for tight control of ileal CD. More studies on noninvasive tests in this location are needed.

Citations

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Fecal calprotectin, intestinal ultrasound, and their combination for the diagnosis of inflammatory bowel disease
Serge Dubian, Clara Yzet, Franck Brazier, Thierry Yzet, Vincent Hautefeuille, Catherine Decrombecque, Quentin Bocquillon, Nicolas Richard, Anthony Buisson, Jonathan Meynier, Mathurin Fumery
Clinics and Research in Hepatology and Gastroenterology.2025; 49(3): 102549. CrossRef
Clinical Trial: The Effects of Emulsifiers in the Food Supply on Disease Activity in Crohn's Disease: An Exploratory Double‐Blinded Randomised Feeding Trial
Jessica A. Fitzpatrick, Peter R. Gibson, Kirstin M. Taylor, Ellen J. Anderson, Antony B. Friedman, Zaid S. Ardalan, Rebecca L. Smith, Emma P. Halmos
Alimentary Pharmacology & Therapeutics.2025; 61(8): 1276. CrossRef
Transmural Healing Assessed by Combination of Fecal Calprotectin and Intestinal Ultrasonography Is Associated With Reduced Risk of Bowel Damage Progression in Patients With Crohn’s Disease
Julie Huet, Kelly Mathieu, Marie Dodel, Dilek Coban, Maëva Bazoge, Bruno Pereira, Anthony Buisson
Inflammatory Bowel Diseases.2025; 31(10): 2767. CrossRef
Intestinal ultrasound in Crohn’s disease: A systematic review of its role in diagnosis, monitoring, and treatment response
Partha Pal, Mohammad Abdul Mateen, Kanapuram Pooja, Nandhakumar Rajadurai, Rajesh Gupta, Manu Tandan, Nageshwar Reddy Duvvuru
World Journal of Meta-Analysis.2025;[Epub] CrossRef
An Updated Review on Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis
Ravi K Sharma, Alpa Singh, Saurabh Dawra
Journal of Postgraduate Medicine, Education and Research.2025; 60(1): 18. CrossRef
The Chicago Mesenteric Fat Index: A Novel Metric for Point-of-Care Intestinal Ultrasound Evaluation of Mesenteric Fat Wrapping in Crohn’s Disease
Joëlle St-Pierre, Amelia Kellar, Tessa George, Yusuke Miyatani, Noa Krugliak Cleveland, Natalie K Choi, Chuanhong Liao, Evan Fear, Zach Fine, Emma Picker, David T Rubin
Inflammatory Bowel Diseases.2025;[Epub] CrossRef
Parameters of bowel ultrasound in the assessment of IBD activity: a correlative study with clinical, endoscopic, and biomarker indices
May Mohsen Fawzi, Mona Ahmed Amin, Mariam Youssef Ramzy, Ahmed El Shenawy, Mahmoud Wahba
The Egyptian Journal of Internal Medicine.2025;[Epub] CrossRef
Novelties and Perspectives of Intestinal Ultrasound in the Personalised Management of Patients with Inflammatory Bowel Diseases—A Systematic Review
Vasile-Claudiu Mihai, Liliana Gheorghe, Ioana-Irina Rezuș, Alina Ecaterina Jucan, Mihaela-Cristiana Andronic, Otilia Gavrilescu, Mihaela Dranga, Andrei-Mihai Andronic, Cristina Cijevschi Prelipcean, Ciprian Rezuș, Cătălina Mihai
Diagnostics.2024; 14(8): 812. CrossRef
The intestinal ultrasound role in inflammatory bowel disease in clinical practice and a critical appraisal of the current guidelines (mini-review)
Sarah El-Nakeep
The Egyptian Journal of Internal Medicine.2024;[Epub] CrossRef
Intestinal Ultrasonography as an Alternative to Fecal Calprotectin to Monitor Patients with Crohn’s Disease: Experience from a Novice Sonographer
Kelly Mathieu, Jérémy Junda, Régine Minet-Quinard, Dilek Coban, Marie Dodel, Bruno Pereira, Anthony Buisson
Digestive Diseases and Sciences.2024; 69(9): 3402. CrossRef
Intestinal ultrasound for follow-up after 24 weeks of biological therapy in inflammatory bowel disease patients: an Egyptian center experience during the COVID-19 pandemic
Sarah El-Nakeep, Ehab Nashaat, Fatma Alsherif, Mohamed Magdy Salama
Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub] CrossRef
Assessing Active Bowel Inflammation in Crohn's Disease Using Intestinal Ultrasound
Myung‐won You, Sung Kyoung Moon, Yong Dae Lee, Shin Ju Oh, Seong Jin Park, Chang Kyun Lee
Journal of Ultrasound in Medicine.2023; 42(12): 2791. CrossRef
Standardizing Endoscopic Reporting in Patients with IBD: JEDII™ to the Rescue?
Sara Massironi, Alice Laffusa, Tommaso Lorenzo Parigi, Silvio Danese
Digestive Diseases and Sciences.2023; 68(12): 4287. CrossRef
Application of transabdominal ultrasound in Crohn’s disease
Wei-Jie Chen, Lei-Lei Luo, Zhi-Xing Dong, Jing Wu, Xing-Xing Gu, Zhao-Lian Bian
World Chinese Journal of Digestology.2022; 30(8): 364. CrossRef
Is radiological healing alone enough? ‘Can’t take my eyes off’ the mucosa
Su Hyun Park, Sang Hyoung Park
The Korean Journal of Internal Medicine.2022; 37(3): 551. CrossRef

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IBD

Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography: Antonio Carlos da Silva Moraes, Glycia de Freitas Moraes, Antonio Luis Eiras de Araújo, Ronir Raggio Luiz, Celeste Elia, Antonio Jose Carneiro, Heitor Siffert Pereira de Souza; Intest Res 2019;17(2):227-236. Published online April 10, 2019; DOI: https://doi.org/10.5217/ir.2018.00124

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn’s disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD.
Methods
Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Sonographic parameters included wall thickening, stricture, hyperemia, presence of intra-abdominal mass, and fistulas. Patients were evaluated for the clinical activity (Harvey-Bradshaw Index [HBI]), fecal calprotectin (FC) and C-reactive protein (CRP). The USCD performance was assessed using magnetic resonance enterography (MRE) as a criterion standard.
Results
Most measurements obtained with USCD matched the data generated with MRE; however, the agreement improved in clinically active patients where sensitivity, positive predictive value, and accuracy were >80%, considering wall thickening and hyperemia. Complications such as intestinal wall thickening, stricture formation, and hyperemia, were detected in the USCD analysis with moderate agreement with MRE. The best agreement with the USCD analysis was obtained in regard to FC, where the sensitivity, positive predictive value, and accuracy were >70%. The overall performance of USCD was superior to that of HBI, FC and CRP levels, particularly when considering thickening, stricture, and hyperemia parameters.
Conclusions
USCD represents a practical noninvasive and low-cost tool for evaluating patients with ileal or ileocolonic disease, particularly in clinically active CD. Therefore, USCD might become a useful asset in the follow-up of patients with CD.

Citations

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Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn’s Disease: A Systematic Review and Meta-Analysis
Maarten J Pruijt, Floris A E de Voogd, Nahid S M Montazeri, Faridi S van Etten-Jamaludin, Geert R D’Haens, Krisztina B Gecse
Journal of Crohn's and Colitis.2024; 18(6): 958. CrossRef
Comparative study between ultrasound and MR enterography in evaluation of Crohn’s disease
Nada Sayed Mahdy, Sahar Mohammed El-Gaafary, Khaled Hamdy Abdel Mageed, Khaled A. Ali Shehata, Maha Ahmed Sayed AbdelKarim, Essam Mohamed Abdulhafiz
Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub] CrossRef
Could ultrasound alone substitute MR imaging in evaluation of Crohn’s disease complications?
Hany El-Assaly, Asmaa Abdel Baky Mohamed, Hesham Adel Abdel Fattah Mustafa
Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub] CrossRef
Radiology plus ileocolonoscopy versus radiology alone in Crohn’s disease: prognosis prediction and mutual agreement
Hye Kyung Hyun, Jongwook Yu, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
The Korean Journal of Internal Medicine.2022; 37(3): 567. CrossRef
Comparison of Diagnostic Performance of Ultrasonography and Magnetic Resonance Enterography in the Assessment of Active Bowel Lesions in Patients with Crohn’s Disease: A Systematic Review and Meta-Analysis
Da In Lee, Myung-Won You, So Hyun Park, Mirinae Seo, Seong Jin Park
Diagnostics.2022; 12(8): 2008. CrossRef
Fistulizing Crohn's disease
Amy L. Lightner, Jean H. Ashburn, Mantaj S. Brar, Michele Carvello, Pramodh Chandrasinghe, Anthony de Buck van Overstraeten, Phillip R. Fleshner, Gaetano Gallo, Paulo Gustavo Kotze, Stefan D. Holubar, Lillian M. Reza, Antonino Spinelli, Scott A. Strong, P
Current Problems in Surgery.2020; 57(11): 100808. CrossRef

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Association of Gallbladder Polyp with the Risk of Colorectal Adenoma: Jung Won Jeun, Jae Myung Cha, Joung Il Lee, Kwang Ro Joo, Hyun Phil Shin, Jun Uk Lim; Intest Res 2014;12(1):48-52. Published online January 28, 2014; DOI: https://doi.org/10.5217/ir.2014.12.1.48

Abstract PDF PubReader

<b>Background/Aims</b><br/>

Gallbladder polyps and colorectal adenomas share many common risk factors; however, their association has never been studied. The aim of this study was to investigate this association in asymptomatic healthy subjects.

Methods

Consecutive asymptomatic subjects who underwent both screening colonoscopy and abdominal ultrasonography at Kyung Hee University Hospital in Gang Dong between July 2010 and April 2011 were prospectively enrolled. The prevalence of colorectal adenoma was compared between subjects with or without gallbladder polyps. Furthermore, a logistic regression analysis was performed to determine the independent risk factors for colorectal adenoma in these subjects.

Results

Of the 581 participants, 55 presented with gallbladder polyps and 526 did not have gallbladder polyps. Participants with gallbladder polyps showed a trend toward a higher prevalence of colorectal adenoma than those without gallbladder polyps (52.7% vs. 39.2%, P=0.051). Although the result was not statistically significant, gallbladder polyps were found to be a possible risk factor for colorectal adenoma (odds ratio=1.796, 95% confidence interval=0.986-3.269, P=0.055), even after adjusting for potential confounding factors. There was no difference observed in colorectal adenoma characteristics between the two groups.

Conclusions

Our results suggest a possible association between gallbladder polyps and colorectal adenomas. Future studies with larger cohorts are warranted to further investigate this matter.

Citations

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Association between gallbladder disease and colorectal neoplasia: a meta-analysis
Wenbin Geng, Kai Ma, Yizhou Jiang, Shiyu Peng, Xiaoyong Wang
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Masahiro Sogabe, Toshiya Okahisa, Miwako Kagawa, Takanori Kashihara, Shota Fujmoto, Tomoyuki Kawaguchi, Reiko Yokoyama, Kaizo Kagemoto, Hironori Tanaka, Yoshifumi Kida, Tetsu Tomonari, Yasushi Sato, Masahiko Nakasono, Tetsuji Takayama
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Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps?
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Advances in Clinical Medicine.2022; 12(11): 10466. CrossRef
Association of gallbladder diseases with risk of gastrointestinal polyps
Wenbin Geng, Xiangrong Qin, Peng Yang, Junmei Wang, Jing Yu, Xiaoyong Wang
BMC Gastroenterology.2022;[Epub] CrossRef
Gallbladder Polyps Are Associated with Proximal Colon Polyps
Kuan-Chieh Lee, Wen-Juei Jeng, Chen-Ming Hsu, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu
Gastroenterology Research and Practice.2019; 2019: 1. CrossRef
Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study
Alharbi Mohammad
Journal of Surgery and Surgical Research.2019; 5(1): 047. CrossRef
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men
Yen‐Ling Liu, Jin‐Shang Wu, Yi‐Ching Yang, Feng‐Hwa Lu, Chih‐Ting Lee, Wan‐Ju Lin, Chih‐Jen Chang
Journal of Gastroenterology and Hepatology.2018; 33(4): 800. CrossRef
Risk of Colorectal Neoplasia According to Fatty Liver Severity and Presence of Gall Bladder Polyps
Taeyoung Lee, Kyung Eun Yun, Yoosoo Chang, Seungho Ryu, Dong Il Park, Kyuyong Choi, Yoon Suk Jung
Digestive Diseases and Sciences.2016; 61(1): 317. CrossRef
Can gallbladder polyps predict colorectal adenoma or even neoplasia? A systematic review
Konstantinos Stergios, Christos Damaskos, Maximos Frountzas, Nikolaos Nikiteas, Olutunde Lalude
International Journal of Surgery.2016; 33: 23. CrossRef
The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases
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Journal of Korean Medical Science.2015; 30(9): 1288. CrossRef
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Korean Journal of Pancreas and Biliary Tract.2014; 19(2): 64. CrossRef

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