Intestinal Research

Original Articles

Colorectal neoplasia

A survey of current practices in post-polypectomy surveillance in Korea: Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Eun Ran Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoon Yang, on behalf of the Intestinal Tumor Research Group of the Korean Association for the Study of Intestinal Diseases (KASID); Intest Res 2024;22(2):186-207. Published online April 25, 2024; DOI: https://doi.org/10.5217/ir.2023.00109

Abstract PDF Supplementary Material PubReader ePub: Background/Aims
We investigated the clinical practice patterns of post-polypectomy colonoscopic surveillance among Korean endoscopists.
Methods
In a web-based survey conducted between September and November 2021, participants were asked about their preferred surveillance intervals and the patient age at which surveillance was discontinued. Adherence to the recent guidelines of the U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) was also analyzed.
Results
In total, 196 endoscopists completed the survey. The most preferred first surveillance intervals were: a 5-year interval after the removal of 1–2 tubular adenomas < 10 mm; a 3-year interval after the removal of 3–10 tubular adenomas < 10 mm, adenomas ≥ 10 mm, tubulovillous or villous adenomas, ≤ 20 hyperplastic polyps < 10 mm, 1–4 sessile serrated lesions (SSLs) < 10 mm, hyperplastic polyps or SSLs ≥ 10 mm, and traditional serrated adenomas; and a 1-year interval after the removal of adenomas with highgrade dysplasia, >10 adenomas, 5–10 SSLs, and SSLs with dysplasia. In piecemeal resections of large polyps ( > 20 mm), surveillance colonoscopy was mostly preferred after 1 year for adenomas and 6 months for SSLs. The mean USMSTF guideline adherence rate was 30.7%. The largest proportion of respondents (40.8%–55.1%) discontinued the surveillance at the patient age of 80–84 years.
Conclusions
A significant discrepancy was observed between the preferred post-polypectomy surveillance intervals and recent international guidelines. Individualized measures are required to increase adherence to the guidelines.

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Colorectal neoplasia

Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach: Mehran Radak, Hossein Fallahi; Intest Res 2024;22(2):199-207. Published online February 6, 2024; DOI: https://doi.org/10.5217/ir.2023.00162

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a systems biology approach, we investigated the molecular similarities between polyp and CRC.
Methods
We analyzed gene expression profiles, protein-protein interactions, transcription factors, and gene ontology to identify common differentially expressed genes (DEGs) and unravel shared molecular pathways.
Results
Our analysis revealed 520 commonly dysregulated genes in polyps and CRC, serving as potential biomarkers and pivotal contributors to disease progression. Gene ontology analysis elucidated distinct biological processes associated with upregulated and downregulated DEGs in both conditions, highlighting common pathways, including signal transduction, cell adhesion, and positive regulation of cell proliferation. Moreover, protein-protein interaction networks shed light on subnetworks involved in rRNA processing, positive regulation of cell proliferation, mRNA splicing, and cell division. Transcription factor analysis identified major regulators and differentially expressed transcription factors in polyp and CRC. Notably, we identified common differentially expressed transcription factors, including ZNF217, NR3C1, KLF5, GATA6, and STAT3, with STAT3 and NR3C1 exhibiting increased expression.
Conclusions
This comprehensive analysis enriches our understanding of the molecular mechanisms underlying polyp formation and CRC development, providing potential targets for further investigation and therapeutic intervention. Our findings contribute substantively to crafting personalized strategies for refining the diagnosis and treatment of polyps and CRC.

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Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer
Janine Soares, Mariana Eiras, Dylan Ferreira, Daniela A. R. Santos, Marta Relvas-Santos, Beatriz Santos, Martina Gonçalves, Eduardo Ferreira, Renata Vieira, Luís Pedro Afonso, Lúcio Lara Santos, Mário Dinis-Ribeiro, Luís Lima, José Alexandre Ferreira
International Journal of Molecular Sciences.2024; 25(7): 3722. CrossRef

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142 Download
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Reviews

Colorectal neoplasia

Screening and surveillance for hereditary colorectal cancer: Hee Man Kim, Tae Il Kim; Intest Res 2024;22(2):119-130. Published online February 6, 2024; DOI: https://doi.org/10.5217/ir.2023.00112

Abstract PDF PubReader ePub: Hereditary colorectal cancer is a type of cancer that is caused by a genetic mutation. Individuals with a family history of colorectal cancer, or who have a known hereditary syndrome, are at an increased risk of developing the disease. Screening and surveillance are important tools for managing the risk of hereditary colorectal cancer. Screening involves a combination of tests that can detect precancerous or cancerous changes in the colon and rectum. Surveillance involves regular follow-up examinations to monitor disease progression and to identify new developments. The frequency and type of screening and surveillance tests may vary depending on an individual’s risk factors, genetic profile, and medical history. However, early detection and treatment of hereditary colorectal cancer can significantly improve patient outcomes and reduce mortality rates. By implementing comprehensive screening and surveillance strategies, healthcare providers can help individuals at risk of hereditary colorectal cancer to receive timely interventions and make informed decisions about their health. Specific examples of screening and surveillance tests for hereditary colorectal cancer include colonoscopy, genetic testing, and imaging tests. In this review article, we will discuss detailed screening and surveillance of hereditary colorectal cancer.

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Colorectal neoplasia

Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration: Chang Kyo Oh, Young-Seok Cho; Intest Res 2024;22(2):131-151. Published online February 1, 2024; DOI: https://doi.org/10.5217/ir.2023.00115

Abstract PDF PubReader ePub: Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction.

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Editorial

Colorectal neoplasia

To overcome medical gap in screening and surveillance of colorectal cancer during the COVID-19 pandemic: Yoo Min Han; Intest Res 2023;21(4):418-419. Published online October 26, 2023; DOI: https://doi.org/10.5217/ir.2023.00144

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Citations

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Influence of the COVID-19 Pandemic on Patients with Rectal Cancer
Fiona Speichinger, Ann-Kathrin Berg, Ani Stoyanova, Johannes Christian Lauscher, Carsten Kamphues, Katharina Beyer, Claudia Seifarth, Nadia Slavova, Christian Schineis
Journal of Clinical Medicine.2024; 13(12): 3568. CrossRef

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Review

Colorectal neoplasia

Summary and comparison of recently updated post-polypectomy surveillance guidelines: Yoon Suk Jung; Intest Res 2023;21(4):443-451. Published online October 26, 2023; DOI: https://doi.org/10.5217/ir.2023.00107

Abstract PDF PubReader ePub

Recently, updated guidelines for post-polypectomy surveillance have been published by the U.S. Multi‐Society Task Force (USMSTF), the British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England (BSG/ACPGBI/PHE), the European Society of Gastrointestinal Endoscopy (ESGE), the Japan Gastroenterological Endoscopy Society (JGES), and the Korean Multi-Society Taskforce Committee. This review summarizes and compares the updated recommendations of these 5 guidelines. There are some differences between the guidelines for the recommended post-polypectomy surveillance intervals. In particular, there are prominent differences between the guidelines for 1–4 tubular adenomas < 10 mm with low-grade dysplasia (nonadvanced adenomas [NAAs]) and tubulovillous or villous adenomas. The USMSTF, JGES, and Korean guidelines recommend colonoscopic surveillance for patients with 1–4 NAAs and those with tubulovillous or villous adenomas, whereas the BSG/ACPGBI/PHE and ESGE guidelines do not recommend endoscopic surveillance for such patients. Surveillance recommendations for patients with serrated polyps (SPs) are limited. Although the USMSTF guidelines provide specific recommendations for patients who have undergone SPs removal, these are weak and based on very lowquality evidence. Future studies should examine this topic to better guide the surveillance recommendations for patients with SPs. For countries that do not have separate guidelines, we hope that this review article will help select the most appropriate guidelines as per each country’s healthcare environment.

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Causal association between telomere length and colorectal polyps: A bidirectional two-sample Mendelian randomization study
Yin Zhang, Jiaying Wang, Mingyu Zheng, Huanwei Qu, Shuya Yang, Fuzhou Han, Nan Yao, Wenqiang Li, Jun Qu
Medicine.2024; 103(1): e36867. CrossRef
Screening and surveillance for hereditary colorectal cancer
Hee Man Kim, Tae Il Kim
Intestinal Research.2024; 22(2): 119. CrossRef
Screening and Surveillance of Colorectal Cancer: A Review of the Literature
Marcello Maida, Dushyant Singh Dahiya, Yash R. Shah, Angad Tiwari, Harishankar Gopakumar, Ishaan Vohra, Aqsa Khan, Fouad Jaber, Daryl Ramai, Antonio Facciorusso
Cancers.2024; 16(15): 2746. CrossRef

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Original Articles

Colorectal neoplasia

The elderly population are more vulnerable for the management of colorectal cancer during the COVID-19 pandemic: a nationwide, population-based study: Hong Sun Kang, Seung Hoon Jeon, Su Bee Park, Jin Young Youn, Min Seob Kwak, Jae Myung Cha; Intest Res 2023;21(4):500-509. Published online August 29, 2023; DOI: https://doi.org/10.5217/ir.2023.00004

Abstract PDF Supplementary Material PubReader ePub

Background/Aims
The impact of coronavirus disease 2019 (COVID-19) on the management of colorectal cancer (CRC) may worse in elderly population, as almost all COVID-19 deaths occurred in the elderly patients. This study aimed to evaluate the impact of COVID-19 on CRC management in the elderly population.
Methods
The numbers of patients who underwent colonoscopy, who visited hospitals or operated for CRC in 2020 and 2021 (COVID-19 era) were compared with those in 2019, according to 3 age groups (≥70 years, 50–69 years, and ≤49 years), based on the nationwide, population-based database (2019–2021) in South Korea.
Results
The annual volumes of colonoscopy and hospital visits for CRC in 2020 were more significantly declined in the old age group than in the young age group (both P<0.001). In addition, the annual volume of patients operated for CRC numerically more declined in old age group than in young age group. During the first surge of COVID-19 (March and April 2020), old age patients showed statistically significant declines for the monthly number of colonoscopies (–46.5% vs. –39.3%, P<0.001), hospital visits (–15.4% vs. –7.9%, P<0.001), CRC operations (–33.8% vs. –0.7%, P<0.05), and colonoscopic polypectomies (–41.8% vs. –38.0%, P<0.001) than young age patients, compared with those of same months in 2019.
Conclusions
Elderly population are more vulnerable for the management of CRC during the COVID-19 pandemic. Therefore, the elderly population are more carefully cared for in the management of CRC during the next pandemic.

Citations

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To overcome medical gap in screening and surveillance of colorectal cancer during the COVID-19 pandemic
Yoo Min Han
Intestinal Research.2023; 21(4): 418. CrossRef

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191 Download
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1 Crossref

Colorectal neoplasia

Clinical characteristics and risk factors related to polyposis recurrence and advanced neoplasm development among patients with non-hereditary colorectal polyposis: Jihun Jang, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim; Intest Res 2023;21(4):510-517. Published online May 31, 2023; DOI: https://doi.org/10.5217/ir.2022.00139

Abstract PDF PubReader ePub

Background/Aims
Patients with more than 10 cumulative polyps might involve a greater genetic risk of colorectal neoplasia development. However, few studies have investigated the risk factors of polyposis recurrence and development of advanced neoplasms among patients with non-hereditary colorectal polyposis.
Methods
This study included patients (n=855) with 10 or more cumulative polyps diagnosed at Severance Hospital from January 2012 to September 2021. Patients with known genetic mutations related to polyposis, known hereditary polyposis syndromes, insufficient information, total colectomy, and less than 3 years of follow-up were excluded. Finally, 169 patients were included for analysis. We collected clinical data, including colonoscopy surveillance results, and performed Cox regression analyses of risk factors for polyposis recurrence and advanced neoplasm development.
Results
The 169 patients were predominantly male (84.02%), with a mean age of 64.19±9.92 years. The mean number of adenomas on index colonoscopy was 15.33±8.47. Multivariable analysis revealed history of cancer except colon cancer (hazard ratio [HR], 2.23; 95% confidence interval [CI], 1.23–4.01), current smoking (HR, 2.39; 95% CI, 1.17–4.87), and detection of many polyps (≥15) on index colonoscopy (HR, 2.05; 95% CI, 1.21–3.50) were significant risk factors for recurrence of polyposis. We found no statistically significant risk factors for advanced neoplasm development during surveillance among our cohort.
Conclusions
The presence of many polyps (≥15) on index colonoscopy, history of cancer except colon cancer, and current smoking state were significant risk factors for polyposis recurrence among patients with non-hereditary colorectal polyposis.

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Screening and surveillance for hereditary colorectal cancer
Hee Man Kim, Tae Il Kim
Intestinal Research.2024; 22(2): 119. CrossRef

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303 Download
1 Web of Science
1 Crossref

Colorectal neoplasia

Postgastrectomy gastric cancer patients are at high risk for colorectal neoplasia: a case control study: Tae-Geun Gweon, Kyu-Tae Yoon, Chang Hyun Kim, Jin-Jo Kim; Intest Res 2021;19(2):239-246. Published online November 13, 2020; DOI: https://doi.org/10.5217/ir.2020.00009

Abstract PDF PubReader ePub

Background/Aims
Several studies have shown that colorectal neoplasms (CRN) including colorectal cancer (CRC) may be prevalent in patients with gastric cancer. However, in most of these studies, colonoscopy to investigate the prevalence of CRN was performed prior to surgery. We aimed to investigate whether CRN was more prevalent in postgastrectomy gastric cancer patients than in healthy individuals.
Methods
We reviewed the medical records of those patients within a cohort of gastric cancer patients with gastrectomy who underwent colonoscopy between 2016 and 2017. Controls age- and sex-matched with gastric cancer patients at a 2:1 ratio were identified among those who underwent colonoscopy at a health-promotion center. The frequencies of CRN, advanced CRN (ACRN), and CRC among patients with gastrectomy were compared with those in the control subjects. A total of 744 individuals (gastric cancer, 248; control, 496) were included.
Results
The rates of CRN and ACRN in the gastric cancer group were higher than those in the healthy individuals (CRN, 47.6% vs. 34.7%, P< 0.001; ACRN, 16.9% vs. 10.9%, P= 0.020). The rate of CRC was comparable between the 2 groups (2.0% vs. 0.6%, P= 0.125). Multivariate analysis identified previous gastrectomy for gastric cancer and male sex as significant risk factors for (A)CRN.
Conclusions
CRN and ACRN were more prevalent in patients who underwent surgery for gastric cancer than in the control group. Regular surveillance colonoscopy at appropriate intervals is indicated after gastrectomy.

Citations

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Effect of bowel preparation completion time on bowel cleansing efficacy: Prospective randomized controlled trial of different bowel preparation completion times precolonoscopy
Hye Min Kim, Hyo Suk Kim, Young Eun An, Jae Hyuck Chang, Tae Ho Kim, Chang Whan Kim, Tae‐Geun Gweon
Digestive Endoscopy.2024;[Epub] CrossRef
Calcium, Vitamin D, and Colorectal Cancer
Young-Jo Wi, Soo-Young Na
The Korean Journal of Gastroenterology.2023; 82(2): 47. CrossRef
Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study
Sung Hoon Jung, Chul-Hyun Lim, Tae-Geun Gweon, Jinsu Kim, Jung Hwan Oh, Kyu-Tae Yoon, Jee Young An, Jeong‑Seon Ji, Hwang Choi
Digestive Diseases and Sciences.2022; 67(10): 4841. CrossRef
Colonoscopy Insertion in Patients with Gastrectomy: Does Position Impact Cecal Intubation Time?
Jae Hyun Kim, Youn Jung Choi, Hye Jung Kwon, Gyu Man Oh, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
Digestive Diseases and Sciences.2022; 67(9): 4533. CrossRef
Early gastric neoplasms are significant risk factor for colorectal adenoma: A prospective case-control study
Seong-Jung Kim, Jun Lee, Dae Youb Baek, Jun Hyung Lee, Ran Hong
Medicine.2022; 101(32): e29956. CrossRef
Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis
Peter P. Stanich, Dareen Elgindi, Elena Stoffel, Erika Koeppe, Ajay Bansal, Rachel Stetson, Debra L. Collins, Dana Farengo Clark, Eve Karloski, Beth Dudley, Randall E. Brand, Michael J. Hall, Yana Chertock, Brian A. Sullivan, Charles Muller, Alice Hinton,
American Journal of Gastroenterology.2022; 117(11): 1877. CrossRef

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Colorectal neoplasia

Factors associated with the survival of colorectal cancer in Mexico: Carlos Quezada-Gutiérrez, María Teresa Álvarez-Bañuelos, Jaime Morales-Romero, Clara Luz Sampieri, Raúl Enrique Guzmán-García, Evangelina Montes-Villaseñor; Intest Res 2020;18(3):315-324. Published online May 19, 2020; DOI: https://doi.org/10.5217/ir.2019.09179

Abstract PDF PubReader ePub

Background/Aims
Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low levels of schooling and a rural population, adjusted for clinical stage and type of treatment.
Methods
A retrospective study was conducted in a cohort of 305 patients with CRC treated at State Cancer Center, located in Veracruz-Mexico; the follow-up period of 60 months (2012–2016). The survival probability was calculated using the Kaplan-Meier estimator and the log-rank test with 95% confidence intervals (CIs). Prognostic factors were determined using hazard ratio (HR) multivariate Cox regression analysis.
Results
Overall survival was 40% at 60 months. Subjects in the age group ≥ 65 years had a low survival rate of 28% (P= 0.026) and an advanced clinical stage of 22% (P< 0.001). Of the patients with bone metastasis, none survived longer than 5 years (P= 0.008). With respect to the unfavorable prognostic factors identified in the multivariate analysis, a decreased level of schooling was associated with an HR of 7.6 (95% CI, 1.1–54.7), advanced clinical stage was associated with an HR of 2.1 (95% CI, 1.2–4.0), and the presence of metastasis had an HR of 1.8 (95% CI, 1.1–2.9).
Conclusions
Poor prognostic factors include an advanced clinical stage, the presence of metastasis and a low level of schooling. These findings confirm the importance of screening for early diagnosis, diminishing the barriers to accessing treatment and prospectively monitoring the population.

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Colorectal cancer survival disparities in the five regions of Georgia
Meng-Han Tsai, Daramola N. Cabral, Caitlyn Grunert, Justin X. Moore, Hong Qin
PLOS ONE.2024; 19(3): e0301027. CrossRef
Cancer Screening in Low- and Middle-Income Countries
Maria Elena Martinez, Kathleen M. Schmeler, Martin Lajous, Lisa A. Newman
American Society of Clinical Oncology Educational Book.2024;[Epub] CrossRef
Chemo-radiotherapy with 177Lu-PLGA(RGF)-CXCR4L for the targeted treatment of colorectal cancer
Pedro Cruz-Nova, Brenda Gibbens-Bandala, Alejandra Ancira-Cortez, Gerardo Ramírez-Nava, Clara Santos-Cuevas, Myrna Luna-Gutiérrez, Blanca Ocampo-García
Frontiers in Medicine.2023;[Epub] CrossRef
Pan gourmet a base de harina de trigo, linaza y chapulín (Sphenarium purpurascens) como alimento funcional
P.F Gomez- Galicia, I. Parola-Contreras, Juan Gabriel Báez- González, R. Durán-Lugo
Investigación y Desarrollo en Ciencia y Tecnología de Alimentos.2023; 8(1): 379. CrossRef
Correlations between Demographic, Clinical, and Paraclinical Variables and Outcomes in Patients with KRAS-Mutant or KRAS Wild-Type Metastatic Colorectal Cancer—A Retrospective Study from a Tertiary-Level Center in Romania
Edvina Elena Pîrvu, Emilia Severin, Raluca Ileana Pătru, Irina Niță, Stefania Andreea Toma, Roxana Rodica Macarie, Cristina Elena Cocioabă, Ioana Florescu, Simona Coniac
Diagnostics.2023; 13(18): 2930. CrossRef
Immune profile by multiplexed immunohistochemistry associated with recurrence after chemoradiation in rectal cancer
Seung Wook Hong, Seohyun Lee, Yun Jae Kim, Soyeon Ahn, In Ja Park, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jaeil Kim, Sang‐Yeob Kim, Seung‐Jae Myung
Journal of Gastroenterology and Hepatology.2022; 37(3): 542. CrossRef
Comparison of Two Types of 1-L Polyethylene Glycol-ascorbic Acid as Colonoscopic Bowel Preparation: A Prospective Randomized Study
Suh Hyun Choi, Won Eui Yoon, Seung Hyuk Kim, Hee Jun Myung, Seo Hyun Kim, Soon Oh So, Se Hun Kim, Hyun Mi Lee, Yeoun Jung Oh, Jeong Seop Moon, Tae Yeong Park, You Sun Kim
The Korean Journal of Gastroenterology.2022; 80(2): 85. CrossRef
Artificial intelligence-based colorectal polyp histology prediction using narrow-band image-magnifying colonoscopy: a stepping stone for clinical practice
Ji Young Chang
Clinical Endoscopy.2022; 55(5): 699. CrossRef
Education levels and survival in colorectal cancer: is there really an obvious association?
Bruna Valiati, Rodrigo Oliva Perez, Paulo Gustavo Kotze
Intestinal Research.2020; 18(3): 247. CrossRef

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Colorectal neoplasia

Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery: Yun Sik Choi, Wan Soo Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon; Intest Res 2020;18(1):96-106. Published online January 30, 2020; DOI: https://doi.org/10.5217/ir.2019.00092

Abstract PDF PubReader ePub

Background/Aims
We aimed to investigate the proportion of and risk factors for residual cancer and/or lymph node metastasis after surgery was performed because of high-risk pathological features in endoscopic resection specimen of suspected superficial submucosal colorectal cancer (SSMC).
Methods
We reviewed medical records of 497 patients (58.8 ± 9.8 years, 331 males) undergoing endoscopic resection of suspected SSMC. High-risk pathological features included: deep submucosal cancer invasion ≥ 1,000 μm; positive lymphovascular and/or perineural invasion; poorly differentiated adenocarcinoma; and positive resection margin. We investigated the occurrence of additional surgery and residual cancer and/or lymph node involvement in the surgical specimen.
Results
En bloc resection was performed in 447 patients (89.9%). High-risk pathological features were detected in 372 patients (74.8%). Additional surgery was performed in 336 of 372 patients with high-risk pathological features. Of these, 47 surgical specimens (14.0%) showed residual cancer and/or lymph node metastasis. Piecemeal resection was more common in those with residual cancer and/or lymph node involvement than those without (9/47 [19.1%] vs. 24/289 [8.3%], P= 0.032). Positive resection margin was also significantly associated with positive residual cancer and/or lymph node involvement. As the number of high-risk pathological features increased, the risk of regional lymph node metastasis increased proportionally (P= 0.002).
Conclusions
High-risk pathological features were frequently detected after endoscopic resection of suspected SSMC while residual cancer and/or lymph node metastasis were not commonly present in the additional surgical specimen. Further optimized strategy for proper endoscopic management of suspected SSMC is necessary.

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Lucille Quénéhervé, Mathieu Pioche, Jérémie Jacques
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Cecilia Binda, Matteo Secco, Luigi Tuccillo, Chiara Coluccio, Elisa Liverani, Carlo Felix Maria Jung, Carlo Fabbri, Giulia Gibiino
Journal of Clinical Medicine.2024; 13(8): 2292. CrossRef
Prediction of Lymph Node Metastasis in T1 Colorectal Cancer Using Artificial Intelligence with Hematoxylin and Eosin-Stained Whole-Slide-Images of Endoscopic and Surgical Resection Specimens
Joo Hye Song, Eun Ran Kim, Yiyu Hong, Insuk Sohn, Soomin Ahn, Seok-Hyung Kim, Kee-Taek Jang
Cancers.2024; 16(10): 1900. CrossRef
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Cristina Mateos Sanchez, Elvira Quintanilla Lazaro, Luis Ramon Rabago
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Hyun Jin Bae, Hoyeon Ju, Han Hee Lee, Jinsu Kim, Bo-In Lee, Sung Hak Lee, Daeyoun David Won, Yoon Suk Lee, In Kyu Lee, Young-Seok Cho
Surgical Endoscopy.2023; 37(2): 1231. CrossRef
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Soo Min Noh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, In Ja Park, Seok-Byung Lim, Jeong-Sik Byeon
Diseases of the Colon & Rectum.2023; 66(5): 723. CrossRef
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Jieun Lee, Yoo Jin Lee, Jong Won Seo, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Jun Heo, Hyun Seok Lee, Joon Seop Lee, Byung Ik Jang, Kyeong Ok Kim, Kwang Bum Cho, Eun Young Kim, Dae Jin Kim, Yun Jin Chung
Surgical Endoscopy.2023; 37(8): 5865. CrossRef
Usage trends of colorectal endoscopic submucosal dissection according to hospital types based on nationwide claims data
Ji Eun Na, Bohyoung Kim, Sung Hoon Jung, Arum Choi, Sukil Kim, Tae-Oh Kim
Medicine.2023; 102(43): e35514. CrossRef
Risk and Time Pattern of Recurrences After Local Endoscopic Resection of T1 Colorectal Cancer: A Meta-analysis
Hao Dang, Nik Dekkers, Saskia le Cessie, Jeanin E. van Hooft, Monique E. van Leerdam, Philip P. Oldenburg, Louis Flothuis, Jan W. Schoones, Alexandra M.J. Langers, James C.H. Hardwick, Jolein van der Kraan, Jurjen J. Boonstra
Clinical Gastroenterology and Hepatology.2022; 20(2): e298. CrossRef
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Han Hee Lee
Clinical Endoscopy.2022; 55(2): 315. CrossRef
Deep Submucosal Invasion Is Not an Independent Risk Factor for Lymph Node Metastasis in T1 Colorectal Cancer: A Meta-Analysis
Liselotte W. Zwager, Barbara A.J. Bastiaansen, Nahid S.M. Montazeri, Roel Hompes, Valeria Barresi, Katsuro Ichimasa, Hiroshi Kawachi, Isidro Machado, Tadahiko Masaki, Weiqi Sheng, Shinji Tanaka, Kazutomo Togashi, Chihiro Yasue, Paul Fockens, Leon M.G. Moo
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6,124 View
169 Download
15 Web of Science
16 Crossref

Colorectal neoplasia

Microvascular density under magnifying narrow-band imaging endoscopy in colorectal epithelial neoplasms: Takahiro Gonai, Keisuke Kawasaki, Shotaro Nakamura, Shunichi Yanai, Risaburo Akasaka, Kunihiko Sato, Yousuke Toya, Kensuke Asakura, Jun Urushikubo, Yasuko Fujita, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Takayuki Matsumoto; Intest Res 2020;18(1):107-114. Published online November 4, 2019; DOI: https://doi.org/10.5217/ir.2019.00061

Abstract PDF PubReader ePub

Background/Aims
Magnifying endoscopic classification systems, such as the Japan narrow-band imaging (NBI) Expert Team (JNET) classification, have been widely used for predicting the histologic diagnosis and invasion depth of colorectal epithelial tumors. However, disagreement exists among observers regarding magnifying endoscopic diagnosis, because these classification systems are subjective. We herein investigated the utility of endoscopic microvascular density (eMVD) calculated from magnifying NBI endoscopic images in colorectal tumors.
Methods
We reviewed magnifying NBI endoscopic images from 169 colorectal epithelial tumors (97 adenomas, 72 carcinomas/high-grade dysplasias) resected endoscopically or surgically. The eMVD on magnifying NBI endoscopic images was evaluated using image-editing software, and relationships between eMVD and clinical, endoscopic, and pathological findings were retrospectively analyzed.
Results
The eMVD in carcinomas (0.152 ± 0.079) was significantly higher than that in adenomas (0.119 ± 0.059, P< 0.05). The best cutoff value for distinguishing carcinoma from adenoma was 0.133. Sensitivity, specificity, and accuracy were 56.9%, 67.0%, and 62.7%, respectively. In addition, JNET type 2B tumors showed significantly higher eMVD (0.162 ± 0.079) compared to type 2A tumors (0.111 ± 0.050, P< 0.05).
Conclusions
The eMVD as determined by magnifying NBI endoscopy is considered to be a possible objective indicator for differentiating colorectal carcinomas from adenomas.

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Frontiers in Robotics and AI.2023;[Epub] CrossRef
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Yu Mi Lee, Kyung Ho Song, Hoon Sup Koo, Choong-Sik Lee, Inseok Ko, Sang Hyuk Lee, Kyu Chan Huh
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Focused Review

Colorectal neoplasia

Nutritional issues in patients with cancer: Duk Hwan Kim; Intest Res 2019;17(4):455-462. Published online October 14, 2019; DOI: https://doi.org/10.5217/ir.2019.00076

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Cancer is a catabolic inflammatory disease that causes patients to often experience weight loss, or even cachexia in severe cases. Undernourishment in patients with cancer impairs the quality of life and therapeutic response, further leading to poor prognosis. Active and frequent nutritional screening and assessment using valid tools are important for fast and appropriate nutritional intervention. Additionally, a suitable individualized nutritional intervention strategy should be established based on the nutritional assessment result. In general, nutritional intervention begins with nutritional counseling of patients diagnosed with cancer, and a well-planned nutritional counseling improves the treatment adherence and nutritional status. When planning nutritional supplementation for cancer patients, specific nutrients, including amino acids and fatty acids, should be considered. However, there has been no consistent result showing that any particular nutrient significantly improves the prognosis of cancer patients. Hence, continuous attention from clinical physicians is needed to plan nutritional improvement in patients with cancer.

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Original Article

Colorectal neoplasia

Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells: Shi Mao Zhu, Yong Ran Park, Seung Yong Seo, In Hee Kim, Soo Teik Lee, Sang Wook Kim; Intest Res 2019;17(4):527-536. Published online August 23, 2019; DOI: https://doi.org/10.5217/ir.2019.00031

Abstract PDF PubReader ePub

Background/Aims
Transforming growth factor-β1 (TGF-β1) induction of epithelial-mesenchymal transition (EMT) is one of the mechanisms by which colorectal cancer (CRC) cells acquire migratory and invasive capacities, and subsequently metastasize. Parthenolide (PT) expresses multiple anti-cancer and anti-inflammatory activities that inhibit nuclear factor κB by targeting the IκB kinase complex. In the present study, we aimed to investigate whether PT can inhibit TGF-β1-induced EMT in CRC cell lines.
Methods
HT-29 and SW480 cell lines were used in the experiment. Cell viability was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and sub-G1 analysis was measured by flow cytometry. The induction of EMT by TGF-β1 and inhibition of the process by PT was analyzed by phase contrast microscopy, wounding healing, cellular migration and invasion assays, and Western blotting.
Results
TGF-β1 inhibits HT-29 cell proliferation, but has no effect on SW480 cell proliferation; different concentrations of TGF-β1 did not induce apoptosis in HT-29 and SW480 cells. PT attenuates TGF-β1-induced elongated, fibroblast-like shape changing in cells. PT inhibits TGF-β1-induced cell migration and cell invasion. In addition, other EMT markers such as β-catenin, Vimentin, Snail, and Slug were suppressed by PT, while E-cadherin was increased by PT.
Conclusions
Our findings show that PT inhibits TGF-β1-induced EMT by suppressing the expression of the mesenchymal protein and increasing expression of the epithelial protein. These findings suggest a novel approach for CRC treatment by suppression of TGF-β1-induced EMT.

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Allan M. Johansen, Steven D. Forsythe, Callum T. McGrath, Grayson Barker, Hugo Jimenez, Ravi K. Paluri, Boris C. Pasche
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Life Sciences.2023; 331: 122037. CrossRef
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Nima Zafari, Mahla Velayati, Mohammadreza Nassiri, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan
Current Pharmaceutical Design.2022; 28(28): 2298. CrossRef
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Case Report

Colorectal neoplasia

Primary malignant melanoma without melanosis of the colon: Nam Hee Yi, Sang Heon Lee, Sang Heon Lee, Ji Hyun Kim, Sam Ryong Jee, Sang Yong Seol; Intest Res 2019;17(4):561-564. Published online August 5, 2019; DOI: https://doi.org/10.5217/ir.2019.00020

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Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. Reported cases of PMM of the lower gastrointestinal tract typically describe anal and rectal involvement rather than colonic lesions. This report describes a rare case of a 50-year-old woman with PMM originating in the colon. The patient presented to Inje University Busan Paik Hospital with a 3-day history of blood-tinged stools. She underwent colonoscopy for a diagnosis of hematochezia. The colonoscopic examination revealed a large-sized semi-pedunculated sigmoid colon polyp with a reddish-colored mucosal surface. Endoscopic mucosal resection was performed, and the final histopathological findings were consistent with a diagnosis of malignant melanoma. Systemic work-up was performed for assessment of metastasis and to identify the primary tumor considering the high metastatic rate of gastrointestinal malignant melanoma; however, no other malignant lesion was detected. Thus, she was diagnosed with colonic PMM. She underwent laparoscopic low anterior resection and lymph node dissection and has been recurrence-free for > 2 years.

Citations

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Malignant primary melanoma of the colon: a case report
Claire K Foley, Marybeth S Hughes, Charles T Hehman
Journal of Surgical Case Reports.2023;[Epub] CrossRef

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179 Download
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1 Crossref

Original Articles

Colorectal neoplasia

Endoscopic features of gastrointestinal stromal tumor in the small intestine: Yutaro Ihara, Takehiro Torisu, Tomohiko Moriyama, Junji Umeno, Atsushi Hirano, Yasuharu Okamoto, Yoshifumi Hori, Hidetaka Yamamoto, Takanari Kitazono, Motohiro Esaki; Intest Res 2019;17(3):398-403. Published online July 25, 2019; DOI: https://doi.org/10.5217/ir.2018.00161

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Background/Aims
Gastrointestinal stromal tumor (GIST) is one of the most common types of submucosal tumors (SMTs). Because of GIST’s malignant potential, it is crucial to differentiate it from other SMTs. The present study aimed to identify characteristic endoscopic findings of GISTs in the small intestine.
Methods
We reviewed the clinicopathological and endoscopic findings of 38 patients with endoscopically or surgically resected SMTs in the small intestine. SMTs were classified into GIST and non-GIST groups, and clinicopathological and endoscopic findings were compared between the 2 groups.
Results
Fifteen patients had GIST and 23 patients had other types of SMTs in the small intestine. Comparison of the endoscopic findings between the 2 groups revealed that dilated vessels in the surrounding mucosa were significantly more in number in the GIST group than in the non-GIST group (P<0.05). However, there were no other differences in endoscopic findings between the 2 groups. Among patients with GISTs, the presence of dilated vessels in the surrounding mucosa was not associated with bleeding risk, tumor size, or metastasis rate at diagnosis.
Conclusions
Dilated vessels in the surrounding mucosa, identified during balloon-assisted endoscopy, may be a diagnostic indicator for GIST in the small intestine. However, its clinical significance should be further analyzed.

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Colorectal neoplasia

Clinical outcomes of positive resection margin after endoscopic mucosal resection of early colon cancers: Junseok Park, Hyun Gun Kim, Shin Ok Jeong, Hoon gil Jo, Hyo Yeop Song, Jeeyeon Kim, Seri Ryu, Youngyun Cho, Hyun Jin Youn, Seong Ran Jeon, Jin-Oh Kim, Bong Min Ko, Yoon Mi Jeen, So-Young Jin; Intest Res 2019;17(4):516-526. Published online May 31, 2019; DOI: https://doi.org/10.5217/ir.2018.00169

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Background/Aims
When determining the subsequent management after endoscopic resection of the early colon cancer (ECC), various factors including the margin status should be considered. This study assessed the subsequent management and outcomes of ECCs according to margin status.
Methods
We examined the data of 223 ECCs treated by endoscopic mucosal resection (EMR) from 215 patients during 2004 to 2014, and all patients were followed-up at least for 2 years.
Results
According to histological analyses, the margin statuses of all lesions after EMR were as follows: 138 cases (61.9%) were negative, 65 cases (29.1%) were positive for dysplastic cells on the resection margins, and 20 cases (8.9%) were uncertain. The decision regarding subsequent management was affected not only by pathologic outcomes but also by the endoscopist’s opinion on whether complete resection was obtained. Surgery was preferred if the lesion extended to the submucosa (odds ratio [OR], 25.46; 95% confidence interval [CI], 7.09–91.42), the endoscopic resection was presumed incomplete (OR, 15.55; 95% CI, 4.28–56.56), or the lymph system was invaded (OR, 13.69; 95% CI, 1.76–106.57). Fourteen patients (6.2%) had residual or recurrent malignancies at the site of the previous ECC resection and were significantly associated with presumed incomplete endoscopic resection (OR, 4.59; 95% CI, 1.21–17.39) and submucosal invasion (OR, 5.14; 95% CI, 1.18–22.34).
Conclusions
Subsequent surgery was associated with submucosa invasion, lymphatic invasion, and cancer-positive margins. Presumed completeness of the resection may be helpful for guiding the subsequent management of patients who undergo endoscopic resection of ECC.

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Review

Colorectal neoplasia

Prevalence and risk factors of colorectal cancer in Asia: Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang; Intest Res 2019;17(3):317-329. Published online May 20, 2019; DOI: https://doi.org/10.5217/ir.2019.00021

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Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly affecting populations in Asian countries. The overall prevalence of CRC is reported to be low in Asia when compared with that in Western nations, yet it had the highest number of prevalent cases. This review described the prevalence of CRC in Asia according to the International Agency for Research on Cancer from World Health Organization (WHO) database and summarized its major risk factors. Non-modifiable factors include genetic factors, ethnicity, age, gender, family history and body height; smoking, alcohol drinking, weight, Westernized diet, physical inactivity, chronic diseases and microbiota were involved in environmental factors. These risk factors were separately discussed in this review according to published literature from Asian countries. CRC screening has been playing an important role in reducing its disease burden. Some recommendations on its screening practices have been formulated in guidelines for Asia Pacific countries.

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Cancer Epidemiology.2024; 91: 102598. CrossRef
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The Korean Journal of Internal Medicine.2022; 37(2): 294. CrossRef
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Ji-Bin Li, Zhi-Yu Qiu, Yu-Xiang Deng, Yin Li, Zhuo-Chen Lin, Yan-Ping Wu, Fan Weng, Huan Tian, Qing-Jian Ou, Cheng-Hua Gong, Zhi-Zhong Pan, De-Sen Wan, Jian-Hong Peng, Yu-Jing Fang
Discover Oncology.2022;[Epub] CrossRef
Amelioration of DMH-induced colon cancer by eupafolin through the reprogramming of apoptosis-associated p53/Bcl2/Bax signaling in rats
Congcong Wang, Xiao Qiao, Jingwen Wang, Jia Yang, Chen Yang, Yi Qiao, Yue Guan, Aidong Wen, Liuqin Jiang
European Journal of Inflammation.2022; 20: 205873922110697. CrossRef
Colorectal cancer patients advocating screening to their siblings: a randomized behavioral intervention
Lina Choe, Jerrald Lau, Si-Ying Fong, Emily Chew, Wen-Min Chow, Yan Pang, Tian-Zhi Lim, Choon-Seng Chong, Min-Hoe Chew, Fung-Joon Foo, Frederick Hong-Xiang Koh, Mee-Lian Wong, Gerald Choon-Huat Koh, Ker-Kan Tan
Gastrointestinal Endoscopy.2022; 95(3): 519. CrossRef
Immune profile by multiplexed immunohistochemistry associated with recurrence after chemoradiation in rectal cancer
Seung Wook Hong, Seohyun Lee, Yun Jae Kim, Soyeon Ahn, In Ja Park, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jaeil Kim, Sang‐Yeob Kim, Seung‐Jae Myung
Journal of Gastroenterology and Hepatology.2022; 37(3): 542. CrossRef
Screening and Evaluation of Probiotics for Reducing Intestinal Inflammation
雅君陈
Hans Journal of Food and Nutrition Science.2022; 11(01): 44. CrossRef
Factors Associated With Colorectal Cancer Screening Among First-Degree Relatives of Patients With Colorectal Cancer in China
Qianqian Du, Jingyu Chen, Ya Meng, Ni Gong, Xiaodan Wu, Qiyuan Lyu, Yiheng Zhang, Xiaoyu Wu, Meifen Zhang
Cancer Nursing.2022; 45(2): E447. CrossRef
Detection and isolation of typical gut indigenous bacteria in mice fed corn starch, bread flour or whole wheat flour
Natsumi Takei, Takashi Kuda, Natsumi Handa, Hajime Takahashi, Bon Kimura
Food Bioengineering.2022; 1(1): 91. CrossRef
Locations and histopathology of colorectal polyps in Turkey: experiences of two centers
Zeynep S. BAHCE, Serdar GUMUS, Ebral YIGIT
Chirurgia.2022;[Epub] CrossRef
Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3–4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis
Suyeon Park, Seong Ran Jeon, Hyun Gun Kim, Yunho Jung, Min-Seob Kwak, Su Young Kim, Jong Wook Kim, Seung-Joo Nam, Eun Hye Oh, Seon-Young Park, Soo-Kyung Park, Jeong-Sik Byeon, Sun-Jin Boo, Dong Hoon Baek, Soon Man Yoon, Jaeyoung Chun, Jooyoung Lee, Miyoun
American Journal of Gastroenterology.2022; 117(4): 588. CrossRef
Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art
Alessia Chini, Michele Manigrasso, Grazia Cantore, Rosa Maione, Marco Milone, Francesco Maione, Giovanni Domenico De Palma
Clinical Endoscopy.2022; 55(2): 183. CrossRef
Meta-Analysis of the Association between Dietary Inflammatory Index (DII) and Colorectal Cancer
Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Mohd Hasni Ja’afar, Zaleha Md Isa, Huan-Keat Chan, Muhammad Radzi Abu Hassan
Nutrients.2022; 14(8): 1555. CrossRef
Report of 13-year survival of patients with colon and rectal cancers; lessons from Shiraz colorectal cancer surgery registry system of a level three medical center
Ali Reza Safarpour, Alimohammad Bananzadeh, Ahmad Izadpanah, Leila Ghahramani, Seyed Mohammad Kazem Tadayon, Faranak Bahrami, Seyed Vahid Hosseini
BMC Surgery.2022;[Epub] CrossRef
Effects of Jianpi Lishi Jiedu granules on colorectal adenoma patients after endoscopic treatment: study protocol for a randomized, double-blinded, placebo-controlled clinical trial
Hao Wu, Yuzhen Huang, Lu Yang, Kunhan Su, Shuo Tian, Xin Chen, Siyu Li, Wanli Liu
Trials.2022;[Epub] CrossRef
Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
Oluwafemi Adeleke Ojo, Temiloluwa Rhoda Adeyemo, Damilare Rotimi, Gaber El-Saber Batiha, Gomaa Mostafa-Hedeab, Matthew Eboseremen Iyobhebhe, Tobiloba Christiana Elebiyo, Bukola Atunwa, Adebola Busola Ojo, Clara Mariana Goncalves Lima, Carlos Adam Conte-Ju
Frontiers in Oncology.2022;[Epub] CrossRef
Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin
Ruting Zhong, Mohamed A. Farag, Meiwan Chen, Chengwei He, Jianbo Xiao
eFood.2022;[Epub] CrossRef
The Influence of Face Shields on the Quality of Colonoscopy in the Era of the COVID-19 Pandemic
Jin Wook Lee, Hyo Jeong Lee, Dae Sung Kim, Jiyoung Yoon, Seung Wook Hong, Ha Won Hwang, Jong-Soo Lee, Gwang-Un Kim, Sinwon Lee, Jaewon Choe, Jin Hwa Park, Dong-Hoon Yang, Jeong-Sik Byeon
Gut and Liver.2022; 16(3): 404. CrossRef
rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis
Refka Jelassi, Sabrine Dhouioui, Hamza Ben Salah, Nasreddine Saidi, Nabiha Mzoughi, Radhia Ammi, Aida Bouratbine, Karim Aoun, Ines Zidi, Hanen Chelbi
Frontiers in Genetics.2022;[Epub] CrossRef
Quality indicators in colonoscopy: the chasm between ideal and reality
Su Bee Park, Jae Myung Cha
Clinical Endoscopy.2022; 55(3): 332. CrossRef
Tumor Detection on Microarray Data Using Grey Wolf Optimization with Gain Information
K. Dhana Sree Devi, P. Karthikeyan, Usha Moorthy, K. Deeba, V. Maheshwari, Shaikh Muhammad Allayear, Shimin Wang
Mathematical Problems in Engineering.2022; 2022: 1. CrossRef
A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population
Hafeez Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch’ng Ewe Seng, Siti Norasikin Binti Mohd Nafil, Ahmad Aizat Bin Abdul Aziz, Yusuf Wada, Ahmad Irekeola, Syed Sameer Aga
BioMed Research International.2022; 2022: 1. CrossRef
Title: Involvement of unsaturated fatty acid biosynthesis in CRC progression based on in vitro and in silico studies
Khatere Mokhtari, Mohammad Mahdevar, Maral Hajipour, Maryam Esmaeili, Maryam Peymani, Sepideh Mirzaei, Mohammad Hossein Nasr-Esfahani, Mehrdad Hashemi, Kiavash Hushmandi, Kamran Ghaedi
Biomedicine & Pharmacotherapy.2022; 153: 113338. CrossRef
Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats
Yongjian Liu, Xin Qi
Journal of Oleo Science.2022; 71(7): 1021. CrossRef
Utility of artificial intelligence with deep learning of hematoxylin and eosin-stained whole slide images to predict lymph node metastasis in T1 colorectal cancer using endoscopically resected specimens; prediction of lymph node metastasis in T1 colorecta
Joo Hye Song, Yiyu Hong, Eun Ran Kim, Seok-Hyung Kim, Insuk Sohn
Journal of Gastroenterology.2022; 57(9): 654. CrossRef
Plant-derived bioactive compounds in colon cancer treatment: An updated review
Akanksha Esmeeta, Subhamay Adhikary, V. Dharshnaa, P. Swarnamughi, Z. Ummul Maqsummiya, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Biomedicine & Pharmacotherapy.2022; 153: 113384. CrossRef
Harmol alleviates dimethylhydrazine induced colon cancer by downregulating Bcl2/IL-6/TNF-α expression in association with p53 mediated apoptosis
Ni Guo, Jie Gao
European Journal of Inflammation.2022; 20: 1721727X2211100. CrossRef
Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians
Jie Ping, Yaohua Yang, Wanqing Wen, Sun‐Seog Kweon, Koichi Matsuda, Wei‐Hua Jia, Aesun Shin, Yu‐Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong‐Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min‐Ho Shin, Chizu Tanikawa, Zhi‐Zhong Pan, Jae Hwan Oh,
International Journal of Cancer.2022; 151(10): 1726. CrossRef
The emerging era of personalized medicine in advanced colorectal cancer
Claudia W K Wu, Madeleine Reid, Simon Leedham, Rashid N Lui
Journal of Gastroenterology and Hepatology.2022; 37(8): 1411. CrossRef
Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
Scientific Reports.2022;[Epub] CrossRef
Long-Time Trend of Colorectal Cancer Mortality Attributable to High Processed Meat Intake in China and a Bayesian Projection from 2020 to 2030: A Model-Based Study
Fangyao Chen, Shiyu Chen, Yaqi Luo, Aima Si, Yuhui Yang, Yemian Li, Weiwei Hu, Yuxiang Zhang
International Journal of Environmental Research and Public Health.2022; 19(17): 10603. CrossRef
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
International Journal of Nanomedicine.2022; Volume 17: 3933. CrossRef
Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital
Nur Rahadiani, Muhammad Habiburrahman, Murdani Abdullah, Wifanto Saditya Jeo, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni
BMJ Open.2022; 12(9): e060839. CrossRef
Colorectal cancer in patients with SARS-CoV-2: a systematic review and meta-analysis
Saad Alhumaid, Abbas Al Mutair, Jawad S. Busubaih, Nourah Al Dossary, Murtadha Alsuliman, Sarah A. Baltyour, Ibrahim Alissa, Hassan I. Al Hassar, Noor A. Al Aithan, Hani A. Albassri, Suliman A. AlOmran, Raed M. ALGhazal, Ahmed Busbaih, Nasser A. Alsalem,
Infectious Agents and Cancer.2022;[Epub] CrossRef
Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Journal of Personalized Medicine.2022; 12(10): 1566. CrossRef
ERCC1 Overexpression Increases Radioresistance in Colorectal Cancer Cells
Yi-Jung Huang, Ming-Yii Huang, Tian-Lu Cheng, Shih-Hsun Kuo, Chien-Chih Ke, Yi-Ting Chen, Yuan-Chin Hsieh, Jaw-Yuan Wang, Chiu-Min Cheng, Chih-Hung Chuang
Cancers.2022; 14(19): 4798. CrossRef
Dietary Nonstarch Polysaccharide Intake and Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
Cancer Research Communications.2022; 2(10): 1304. CrossRef
Expression of Vascular Endothelial Growth Factor (VEGF) in Colorectal Adenoma and Carcinoma in a Tertiary Care Center
Subalakshmi Balasubramanian, Nagarajan Priyathersini, Thanka Johnson
Cureus.2022;[Epub] CrossRef
Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review
Wei-Jian Mei, Mi Mi, Jing Qian, Nan Xiao, Ying Yuan, Pei-Rong Ding
Frontiers in Immunology.2022;[Epub] CrossRef
Diagnosis by Volatile Organic Compounds in Exhaled Breath from Patients with Gastric and Colorectal Cancers
Jinwook Chung, Salima Akter, Sunhee Han, Yoonhwa Shin, Tae Choi, Insug Kang, Sung Kim
International Journal of Molecular Sciences.2022; 24(1): 129. CrossRef
Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review
Nur Mahirah Amani Binti Mohammad, Mohd Razif Shahril, Suzana Shahar, Michael Fenech, Razinah Sharif
Journal of Cancer Prevention.2022; 27(4): 208. CrossRef
Inhibition of Cell Proliferation and Induction of Cell Cycle Arrest in Colon Cancer Cells by Lyophilized Mango (Mangifera indicaL.) Pulp Extract
Gustavo Argenor Lozano-Casabianca, Sandra Sulay Arango-Varela, Johanny Aguillón-Osma, María Alejandra Llano-Ramírez, María Elena Maldonado-Celis
Preventive Nutrition and Food Science.2022; 27(4): 436. CrossRef
Hereditary, environmental, and dietary risk factors of colorectal cancer: a case-control study in the Algerian East
Samira Negrichi, Salima Taleb
Environmental Science and Pollution Research.2021; 28(10): 12372. CrossRef
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study
Je-Ming Hu, Chia-Cheng Lee, Tzu-Chiao Lin, Chi-Hsiang Chung, Chao-Yang Chen, Pi-Kai Chang, Cheng-Wen Hsiao, Chien-An Sun, Nian-Sheng Tzeng, Wu-Chien Chien
Frontiers in Psychiatry.2021;[Epub] CrossRef
Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review
Hossein Mozafar Saadati, Batool Okhovat, Farzad Khodamoradi
Journal of Gastrointestinal Cancer.2021; 52(2): 414. CrossRef
Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort
Jung Min Moon, Jong Pil Im, Donghee Kim, Yoo Min Han, Hosim Soh, Ji Hyun Song, Sun Young Yang, Young Sun Kim, Jeong Yoon Yim, Seon Hee Lim, Joo Sung Kim
Journal of Gastroenterology and Hepatology.2021; 36(7): 1836. CrossRef
Dietary Intake as Determinant Nongenetic Factors to Colorectal Cancer Incidence and Staging Progression: A Study in South Sulawesi Population, Indonesia
Ika Nurlaila, Alam A. Hidayat, Arif Budiarto, Bharuno Mahesworo, Kartika Purwandari, Bens Pardamean
Nutrition and Cancer.2021; 73(11-12): 2523. CrossRef
Comparison of Risk of Metachronous Advanced Colorectal Neoplasia in Patients with Sporadic Adenomas Aged < 50 Versus ≥ 50 years: A Systematic Review and Meta-Analysis
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Journal of Personalized Medicine.2021; 11(2): 120. CrossRef
Survival of colorectal cancer patients in Brunei Darussalam: comparison between 2002–09 and 2010–17
Shirley H. F. Lee, Hanif Abdul Rahman, Nadiah Abidin, Sok King Ong, Elvynna Leong, Lin Naing
BMC Cancer.2021;[Epub] CrossRef
Schistosoma japonicum Associated With Colorectal Cancer
Anas Almoghrabi, Obaie Mzaik, Bashar Attar
ACG Case Reports Journal.2021; 8(5): e00572. CrossRef
Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity
Yoonsuk Jung, Eui Im, Jinhee Lee, Hyeah Lee, Changmo Moon
Journal of Personalized Medicine.2021; 11(6): 497. CrossRef
Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
The Korean Journal of Internal Medicine.2021; 36(5): 1083. CrossRef
Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
Yoon Suk Jung
Precision and Future Medicine.2021; 5(2): 69. CrossRef
CTSE Overexpression Is an Adverse Prognostic Factor for Survival among Rectal Cancer Patients Receiving CCRT
Chia-Lin Chou, Tzu-Ju Chen, Yu-Feng Tian, Ti-Chun Chan, Cheng-Fa Yeh, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
Life.2021; 11(7): 646. CrossRef
Risk-stratified colorectal cancer screening for optimal use of colonoscopy resources
Dong-Hoon Yang
The Korean Journal of Internal Medicine.2021; 36(4): 839. CrossRef
Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer
Kangkang Ying, Bingjun Bai, Xing Gao, Yuzi Xu, Hangxiang Wang, Binbin Xie
Frontiers in Bioengineering and Biotechnology.2021;[Epub] CrossRef
RNA-sequencing identification and validation of genes differentially expressed in high-risk adenoma, advanced colorectal cancer, and normal controls
Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Seung Bin Park, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim, Han-Kyeom Kim
Functional & Integrative Genomics.2021; 21(3-4): 513. CrossRef
Metabolic Evidence Rather Than Amounts of Red or Processed Meat as a Risk on Korean Colorectal Cancer
Eunbee Kim, Joon Seok Lee, Eunjae Kim, Myung-Ah Lee, Alfred N. Fonteh, Michael Kwong, Yoon Hee Cho, Un Jae Lee, Mihi Yang
Metabolites.2021; 11(7): 462. CrossRef
Participation Rate, Risk Factors, and Incidence of Colorectal Cancer in the Screening Program Among the Population Covered by the Health Centers in Arak, Iran
Pegah Mohaghegh, Farzane Ahmadi, Mahjabin Shiravandi, Javad Nazari
International Journal of Cancer Management.2021;[Epub] CrossRef
Detection of Colon Polyps in India—A Large Retrospective Cohort Study (DoCPIr)
Nitin Jagtap, Aniruddha Pratap Singh, Pradev Inavolu, Manu Tandan, Shubhankar Godbole, Pranav Ambardekar, Anuradha Sekaran, Sundeep Lakhtakia, Mohan Ramchandani, Rakesh Kalapala, Rajesh Gupta, P. Manohar Reddy, Zaheer Nabi, Radhika Chavan, G. Venkat Rao,
Journal of Digestive Endoscopy.2021; 12(02): 063. CrossRef
Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers
Yu-Chan Chang, Ming-Hsien Chan, Chien-Hsiu Li, Chih-Yeu Fang, Michael Hsiao, Chi-Long Chen
Biomedicines.2021; 9(8): 931. CrossRef
Extricating the Association Between the Prognostic Factors of Colorectal Cancer
Younis Mohd, Balamuralikrishnan Balasubramanian, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Suresh Kumar Shanmugam, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Sasikala Keshavarao, Vijaya Anand Arumugam
Journal of Gastrointestinal Cancer.2021; 52(3): 1022. CrossRef
Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer
Marewan Abid, Fikry Qadir, Abbas Salihi
Oncology Letters.2021;[Epub] CrossRef
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer
T. Yoshino, G. Argilés, E. Oki, E. Martinelli, H. Taniguchi, D. Arnold, S. Mishima, Y. Li, B.K. Smruti, J.B. Ahn, I. Faud, C.E. Chee, K.-H. Yeh, P.-C. Lin, C. Chua, H.H. Hasbullah, M.A. Lee, A. Sharma, Y. Sun, G. Curigliano, H. Bando, F. Lordick, T. Yaman
Annals of Oncology.2021; 32(12): 1496. CrossRef
Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment
Shamin Azwar, Heng Fong Seow, Maha Abdullah, Mohd Faisal Jabar, Norhafizah Mohtarrudin
Biology.2021; 10(9): 854. CrossRef
Association of four genetic variants with colorectal cancer in Kazakhstan population
Yevgeniya Kolesnikova, Dmitriy Babenko, Irina Kadyrova, Svetlana Kolesnichenko, Lyudmila Akhmaltdinova, Ilya Korshukov, Naylya Kabildina, Valentina Sirota, Vera Zhumaliyeva, Dana Taizhanova, Dmitriy Vazenmiller, Anar Turmukhambetova
Oncotarget.2021; 12(21): 2215. CrossRef
Exosomal circRNAs: new players in colorectal cancer
Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar, Fatemeh Pakdaman
Cancer Cell International.2021;[Epub] CrossRef
Screening and prevention of colorectal cancer
Priyanka Kanth, John M Inadomi
BMJ.2021; : n1855. CrossRef
Can Real-time Computer-Aided Detection Systems Diminish the Risk of Postcolonoscopy Colorectal Cancer?
Mariusz Madalinski, Roger Prudham
JMIR Medical Informatics.2021; 9(12): e25328. CrossRef
Bioinformatic analysis reveals in common genes between colorectal cancer and recurrent colorectal malignancy
Rasoul Nemati, Mehdi Valizadeh, Mehrdad Mohammadi, Atena Kamali
Gene Reports.2021; 25: 101375. CrossRef
Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study
Godfrey Wekha, Nelson Ssewante, Angelique Iradukunda, Micheal Jurua, Shadia Nalwoga, Sharon Lanyero, Ronald Olum, Felix Bongomin
Cancer Management and Research.2021; Volume 13: 7697. CrossRef
Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review
Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Huan-Keat Chan, Muhammad Radzi Abu Hassan
International Journal of Environmental Research and Public Health.2021; 18(19): 10486. CrossRef
Endoscopic submucosal dissection versus endoscopic mucosal resection for rectal carcinoid tumor. A meta‐analysis and meta‐regression with single‐arm analysis
Jie Ning Yong, Xiong Chang Lim, Kameswara Rishi Yeshayahu Nistala, Lincoln Kai En Lim, Grace En Hui Lim, Jingxuan Quek, Hui Yu Tham, Neng Wei Wong, Ker‐Kan Tan, Choon Seng Chong
Journal of Digestive Diseases.2021; 22(10): 562. CrossRef
Detection of Microsatellite Instability in Colorectal Cancer Patients With a Plasma-Based Real-Time PCR Analysis
Namjoo Kim, Sung Min Kim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
Frontiers in Pharmacology.2021;[Epub] CrossRef
The Relationship Between Severity of Gastric Inflammation Due to Helicobacter pylori and Colorectal Malignancies
Oktay BULUR, Evrim Kahramanoğlu AKSOY, Gülçin GÜLER ŞİMŞEK, Murat ESER, Zeliha ASİLTÜRK LÜLLECİ, Kürşat DAL, Metin UZMAN
Cumhuriyet Medical Journal.2021;[Epub] CrossRef
Histomorphology Panorama of Neoplastic Gastrointestinal Lesions in a Tertiary Care Center
Sunita Bamanikar, Dayanand Sonkawade, Parul Bhandari, Arvind Bamanikar, Shirish Chandanwale, Archana Buch
Medical Journal of Dr. D.Y. Patil Vidyapeeth.2021; 14(1): 31. CrossRef
Clinical, Endoscopic and Histological Profile of Colorectal Cancers Seen on Colonoscopy in Kano, North-Western Nigeria
Yusuf Musa, Mansur Femi Mohammed, Nurudeen Olalekan Muhammad, Ibrahim Yusuf, Abdulrashid Onimisi Abdulrahim, Adamu Alhaji Samaila, Musa Muhammad Borodo
Nigerian Postgraduate Medical Journal.2021; 28(1): 22. CrossRef
Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Gastrointestinal Endoscopy.2020; 91(3): 622. CrossRef
miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells
Fanhua Kong, Heng Zou, Xi Liu, Jun He, Yanwen Zheng, Li Xiong, Xiongying Miao
Photodiagnosis and Photodynamic Therapy.2020; 29: 101663. CrossRef
Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer
Ayat B. Al-Ghafari, Khadijah S. Balamash, Huda A. Al Doghaither
Saudi Journal of Biological Sciences.2020; 27(3): 827. CrossRef
Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma
Heng Zhang, Yusheng Liao, Hongfeng Zhang, Jie Wu, Dan Zheng, Zhitao Chen
The International Journal of Biological Markers.2020; 35(1): 19. CrossRef
Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery
Yun Sik Choi, Wan Soo Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Intestinal Research.2020; 18(1): 96. CrossRef
Fisetin suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway
Qingling Fan, Xiaoye Wang, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Qingkui Wang
Journal of King Saud University - Science.2020; 32(3): 1959. CrossRef
The relationship between metabolic syndrome and the incidence of colorectal cancer
JungHyun Lee, Kun Sei Lee, Hyeongsu Kim, Hyoseon Jeong, Min-Jung Choi, Hai-Won Yoo, Tae-Hwa Han, Hyunjung Lee
Environmental Health and Preventive Medicine.2020;[Epub] CrossRef
Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions
Lorenzo Polimeno, Michele Barone, Adriana Mosca, Maria Teresa Viggiani, Farahnaz Joukar, Fariborz Mansour-Ghanaei, Sara Mavaddati, Antonella Daniele, Lucantonio Debellis, Massimo Bilancia, Luigi Santacroce, Alfredo Di Leo
Microorganisms.2020; 8(4): 469. CrossRef
Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer
Sun Young Kim, Tae Won Kim
ESMO Open.2020; 5(2): e000634. CrossRef
Strategies to Increase the Participation Rate of Colorectal Cancer Screening
Yoon Suk Jung
Gut and Liver.2020; 14(3): 277. CrossRef
The incidence and patterns of colorectal cancers in Sri Lanka from 2001 to 2010: Analysis of national cancer registry data
Umesh Jayarajah, Viraj Udayanga, Ashan Fernando, Dharmabandhu N. Samarasekera, Sanjeewa Seneviratne
European Journal of Cancer Care.2020;[Epub] CrossRef
The association between Ki-67 expression and the clinical pathological characteristics of colorectal cancer
Jing Li, Zhi-ye Liu, Hai-bo Yu, Xiu-sheng Qu, Qing Xue, Hai-tao Yu, Christina Weeks
Medicine.2020; 99(21): e19996. CrossRef
Detection of colon cancer based on microarray dataset using machine learning as a feature selection and classification techniques
A. S. M. Shafi, M. M. Imran Molla, Julakha Jahan Jui, Mohammad Motiur Rahman
SN Applied Sciences.2020;[Epub] CrossRef
Hospital-Based Preliminary Observations of Dietary Intake and Physical Activity in Saudi Patients with Colorectal Polyps: A Call for Nutrition Care Integration after Polypectomy Procedure
Areej Ali Alkhaldy
Gastrointestinal Disorders.2020; 2(2): 96. CrossRef
Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model
David Bars-Cortina, Ana Martínez-Bardají, Alba Macià, María-Jose Motilva, Carme Piñol-Felis
The Journal of Nutritional Biochemistry.2020; 83: 108418. CrossRef
circPDSS1 Stimulates the Development of Colorectal Cancer via Activating the Wnt/β-Catenin Signaling

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OncoTargets and Therapy.2020; Volume 13: 6329. CrossRef
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Rodney Hull, Flavia Zita Francies, Meryl Oyomno, Zodwa Dlamini
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Radiological staging of rectal cancer in a resource limited setting
Naradha Lokuhetty, Suranjith L. Seneviratne, Fathima Asma Rahman, Thanushka Marapana, Roshan Niloofa, Ishan De Zoysa
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Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer
Yoon Suk Jung, Jinhee Lee, Hye Ah Lee, Chang Mo Moon
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Malaksima Ayadilord, Tahmine Tavakoli, Tahereh Fakharian, Ehsan Soltaninejad, Mohsen Naseri
Meta Gene.2020; 26: 100813. CrossRef
Expression of Main Toll-Like Receptors in Patients with Different Types of Colorectal Polyps and Their Relationship with Gut Microbiota
Sama Rezasoltani, Reza Ghanbari, Mehdi Azizmohammad Looha, Ehsan Nazemalhosseini Mojarad, Abbas Yadegar, Delisha Stewart, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
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Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
Pi-Yueh Chang, Shih-Cheng Chang, Mei-Chia Wang, Jinn-Shiun Chen, Wen-Sy Tsai, Jeng-Fu You, Chia-Chun Chen, Hsiu-Ling Liu, Jy-Ming Chiang
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Obesity Has a Stronger Relationship with Colorectal Cancer in Postmenopausal Women than Premenopausal Women
Ji Won Chang, Dong Wook Shin, Kyung Do Han, Keun Hye Jeon, Jung Eun Yoo, In Young Cho, Yun Jin Choi, Jung Yong Hong
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(11): 2277. CrossRef
The significance of colorectal cancer in the morbidity and mortality of the adult population of the South Banat District in the period from 2010 to 2019
Aleksandra Perović, Jasmina Pavlović-Stojanović, Ljiljana Lazić, Dragana Antonijević-Đorđević, Magdalena Bjelica, Ivana Popov, Veronika Popovski
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Marwan Al-Hajeili, HassanK Abdulwassi, Faisal Alshadadi, Lujain Alqurashi, Mohmmad Idriss, Lamis Halawani
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Brief Communication

Colorectal neoplasia

Lack of reliability of self-reports by patients with advanced colorectal polyps: Benjamin Fiedler, Lawrence Fiedler, Michael A. DeDonno, Kosi Anago, Leonie de la Cruz, George R. Luck, Charles H. Hennekens; Intest Res 2019;17(2):278-280. Published online December 14, 2018; DOI: https://doi.org/10.5217/ir.2018.00144

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Underutilization of Aspirin in Patients With Advanced Colorectal Polyps
Benjamin Fiedler, Lawrence Fiedler, Michael DeDonno, Kosi Anago, Leonie de la Cruz, George R. Luck, Charles H. Hennekens
The American Journal of Medicine.2019;[Epub] CrossRef

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Original Articles

Colorectal neoplasia

Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years: Ji Yeon Kim, Sungkyoung Choi, Taesung Park, Seul Ki Kim, Yoon Suk Jung, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Kyu Yong Choi, Dong Il Park; Intest Res 2019;17(2):253-264. Published online November 20, 2018; DOI: https://doi.org/10.5217/ir.2018.00062

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Background/Aims
Colorectal cancer incidence among patients aged ≤50 years is increasing. This study aimed to develop and validate an advanced colorectal neoplasm (ACRN) screening model for young adults aged <50 years in Korea.
Methods
This retrospective cross-sectional study included 59,575 consecutive asymptomatic Koreans who underwent screening colonoscopy between 2003 and 2012 at a single comprehensive health care center. Young Adult Colorectal Screening (YCS) score was developed as an optimized risk stratification model for ACRN using multivariate analysis and was internally validated. The predictive power and diagnostic performance of YCS score was compared with those of Asia-Pacific Colorectal Screening (APCS) and Korean Colorectal Screening (KCS) scores.
Results
41,702 and 17,873 subjects were randomly allocated into the derivation and validation cohorts, respectively, by examination year. ACRN prevalence was 0.9% in both cohorts. YCS score comprised sex, age, alcohol, smoking, obesity, glucose metabolism abnormality, and family history of CRC, with score ranges of 0 to 10. In the validation cohort, ACRN prevalence was 0.6% in the low-risk tier (score, 0–4), 1.5% in the moderate-risk tier (score, 5–7), and 3.4% in the high-risk tier (score, 8–10). ACRN risk increased 2.5-fold (95%CI, 1.8–3.4) in the moderate-risk tier and 5.8-fold (95%CI, 3.4–9.8) in the high-risk tier compared with the low-risk tier. YCS score identified better balanced accuracy (53.9%) than APCS (51.5%) and KCS (50.7%) scores and had relatively good discriminative power (area under the curve=0.660).
Conclusions
YCS score based on clinical and laboratory risk factors was clinically effective and beneficial for predicting ACRN risk and targeting screening colonoscopy in adults aged <50 years.

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Performance of the Asia–Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: A meta‐analysis and systematic review
Mai Ngoc Luu, Nhi Ai Trinh, Truc Le Thanh Tran, Thinh Phuong Dang, Toru Hiyama, Duc Trong Quach
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Junjie Huang, Don Eliseo Lucero-Prisno, Lin Zhang, Wanghong Xu, Sunny H. Wong, Siew C. Ng, Martin C. S. Wong
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From Algorithms to Clinical Utility: A Systematic Review of Individualized Risk Prediction Models for Colorectal Cancer
Deborah Jael Herrera, Wessel van de Veerdonk, Daiane Maria Seibert, Moges Muluneh Boke, Claudia Gutiérrez-Ortiz, Nigus Bililign Yimer, Karen Feyen, Allegra Ferrari, Guido Van Hal
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Tomotaka Ugai, Naoko Sasamoto, Hwa-Young Lee, Mariko Ando, Mingyang Song, Rulla M. Tamimi, Ichiro Kawachi, Peter T. Campbell, Edward L. Giovannucci, Elisabete Weiderpass, Timothy R. Rebbeck, Shuji Ogino
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Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
Yoon Suk Jung
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Ji Eun Na, Eun Ran Kim
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Marta Puzzono, Alessandro Mannucci, Simone Grannò, Raffaella Alessia Zuppardo, Andrea Galli, Silvio Danese, Giulia Martina Cavestro
Cancers.2021; 13(23): 5933. CrossRef
Association between waist circumference and risk of colorectal neoplasia in normal‐weight adults
Yoon Suk Jung, Nam Hee Kim, Hyo‐Joon Yang, Soo‐Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
Journal of Gastroenterology and Hepatology.2020; 35(1): 43. CrossRef
Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals
Ala I Sharara, Ali El Mokahal, Ali H Harb, Natalia Khalaf, Fayez S Sarkis, Mustapha M El-Halabi, Nabil M Mansour, Ahmad Malli, Robert Habib
World Journal of Gastroenterology.2020; 26(37): 5705. CrossRef
Risk Factors Associated With Young-Onset Colorectal Adenomas and Cancer: A Systematic Review and Meta-Analysis of Observational Research
Genevieve Breau, Ursula Ellis
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Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intestinal Research.2019; 17(3): 317. CrossRef

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Colorectal neoplasia

Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer: In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee; Intest Res 2019;17(3):404-412. Published online November 12, 2018; DOI: https://doi.org/10.5217/ir.2018.00072

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Background/Aims
To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.
Methods
Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.
Results
The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm2 , respectively (P<0.001). The risk of adenoma positively correlated with VAT area and the visceral-to-total fat ratio (P for trend <0.01), but the risk of CRC did not (P>0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018)
Conclusions
VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.

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Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
Younes Kays Mohammed Ali, Troels Gammeltoft Dolin, Janus Damm Nybing, Jakob Lykke, Frederik Hvid Linden, Erik Høgh-Schmidt, Thorkild I. A. Sørensen, Jesper Frank Christensen, Yousef J. W. Nielsen, Jim Stenfatt Larsen, Sten Madsbad, Julia Sidenius Johansen
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MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo, Hong Xu
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Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
Jung Ho Lee, Hyunseok Cho, Sang Hoon Lee, Sung Joon Lee, Chang Don Kang, Dae Hee Choi, Jin Myung Park, Seung-Joo Nam, Tae Suk Kim, Ji Hyun Kim, Sung Chul Park
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Le Gao, Tian Yang, Ziru Xue, Chak Kwan Dickson Chan
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Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
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Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
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Obesity, sleep apnea, and cancer
Isaac Almendros, Miguel A. Martinez-Garcia, Ramon Farré, David Gozal
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Zi Qin Ng, Ruwan Wijesuriya, Philip Misur, Jih Huei Tan, Kyaw Soe Moe, Mary Theophilus
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Changes in Abdominal Obesity Affect the Risk of Metachronous Advanced Colorectal Neoplasia Development after Polypectomy
Yoon Suk Jung, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
Yonsei Medical Journal.2020; 61(7): 579. CrossRef

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Colorectal neoplasia

Clinical features and outcomes in spontaneous intramural small bowel hematoma: cohort study and literature review: Eun Ae Kang, Seung Jun Han, Jaeyoung Chun, Hyun Jung Lee, Hyunsoo Chung, Jong Pil Im, Sang Gyun Kim, Joo Sung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyun Chae Jung; Intest Res 2019;17(1):135-143. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00085

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Background/Aims
Spontaneous intramural small bowel hematoma (SISBH) is an extremely rare complication of anticoagulant or antiplatelet therapy. We assessed the clinical characteristics and outcomes of patients with SISBH according to the anatomical location of the hematoma.
Methods
From January 2003 to February 2016, medical records for all patients hospitalized for SISBH at 2 tertiary referral hospitals were retrospectively reviewed. The primary outcome was requirement for surgery.
Results
A total of 37 patients were enrolled. The mean age was 74.1 years. Among them, 33 patients (89.2%) were taking anticoagulant and/or antiplatelet agents. Duodenal intramural hematoma was detected in 4 patients (10.8%), jejunal in 16 (43.2%), and ileal in 17 (45.9%). Compared to jejunal and ileal involvement, duodenal intramural hematoma was significantly associated with high Charlson comorbidity index and low levels of white blood cells, hemoglobin, and platelets in the blood. SISBH in the duodenum was related to thrombocytopenia in 3 patients following systemic chemotherapy for malignancy. All patients with SISBH showed clinical improvement with conservative therapy. Mean length of hospital stay was 9.35 days. Independent predictors of a hospital stay of more than 7 days were body weight less than 60 kg (odds ratio [OR], 12.213; 95% confidence interval [CI], 1.755–84.998; P=0.011) and a history of cerebrovascular accidents (OR, 6.667; 95% CI, 1.121–39.650; P=0.037).
Conclusions
Compared to jejunal and ileal involvement, thrombocytopenia may result in spontaneous duodenal intramural hematoma among patients who are treated with systemic chemotherapy for malignancies. Patients with SISBH have excellent clinical outcomes with conservative therapy regardless of the anatomical location of the hematoma.

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A Case of Direct-Acting Oral Anticoagulant-Induced Intramural Colon Hematoma Successfully Treated by Laparoscopic Surgery
Daisuke Tomita, Shigeo Toda, Ryo Miyazaki, Shuichiro Matoba, Hiroya Kuroyanagi
Cureus.2024;[Epub] CrossRef
Spontaneous Intramural Small Bowel Hematoma in an Elderly Man with Multiple Myeloma
Sigrid L. Williamson, Aishwarya Suresh, Adrian Ong
The American Surgeon™.2023; 89(6): 2816. CrossRef
Intramural duodenal hematoma: diagnosis and management of a rare entity
Álvaro Pérez-Rubio, Juan Carlos Sebastián-Tomás, Sergio Navarro-Martínez, Marta Córcoles Córcoles, Carlos Domingo del Pozo
Cirugía Española (English Edition).2023; 101(7): 515. CrossRef
Hematoma intramural duodenal: diagnóstico y manejo de una entidad infrecuente
Álvaro Pérez-Rubio, Juan Carlos Sebastián-Tomás, Sergio Navarro-Martínez, Marta Córcoles Córcoles, Carlos Domingo del Pozo
Cirugía Española.2023; 101(7): 515. CrossRef
Jejunal intramural haematoma in a captive African lion (Panthera leo)
Richelle G. Butcher, Baukje Lenting, Alison S. Clarke, Kelly Buckle, Cristina Gans
Veterinary Record Case Reports.2023;[Epub] CrossRef
Spontaneous Duodenal Hematoma: A Rare Complication of Triple Antithrombotic Therapy Case Report
Mazin N Habhab, Asad J Torabi, Julie M Clary, George E Revtyak
Future Cardiology.2023; 19(2): 71. CrossRef
Intestinal Spontaneous Intramural Hematoma Secondary to Anticoagulation Therapy: A Case Report
Karim El Aidaoui, Wahib Lahlou, Abderrahim Bourial, Nawal Bouknani, Chafik El Kettani
Cureus.2023;[Epub] CrossRef
Intramural Hematoma of Gastrointestinal Tract in People with Hemophilia A and B
Wei-Jung Teng, Ching-Huei Kung, Mei-Mei Cheng, Jia-Ruey Tsai, Chia-Yau Chang
Journal of Clinical Medicine.2023; 12(9): 3093. CrossRef
Endoscopic management of intramural spontaneous duodenal hematoma: A case report
Giorgio Valerii, Vittorio Maria Ormando, Carlo Cellini, Luca Sacco, Carmelo Barbera
World Journal of Gastroenterology.2022; 28(20): 2243. CrossRef
Warfarin-induced spontaneous intramural small bowel hematoma presenting as an acute abdomen: A case report
Ding-Han Chen, Khay-Seng Soh, Ying-Tso Wang, Te-Chun Shen
Medicine.2022; 101(35): e30335. CrossRef
Spontaneous duodenal haematoma in a patient taking rivaroxaban
Rebeca de Barros Lopes, Finn McLennan Battleday, Toby Calvert, Rob Gwynne‐Jones, Rebecca Thomas
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SPONTANEOUS INTRAMURAL SMALL-BOWEL HEMATOMA: A CAUSE OF ACUTE ABDOMEN IN ANTICOAGULATED PATIENTS
Sergio Gil Rojas, Luis Miguel Estela Villa, Elsa María Jiménez Vicente
Revista Española de Enfermedades Digestivas.2021;[Epub] CrossRef
Small Bowel Obstruction
Allison A. Aka, Jesse P. Wright, Teresa DeBeche-Adams
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Colorectal neoplasia

Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer: Yuk Fai Lam, Wai Kay Seto, Teresa Tong, Ka Shing Cheung, Oswens Lo, Ivan FN Hung, Wai Lun Law, Wai K Leung; Intest Res 2018;16(4):619-627. Published online October 10, 2018; DOI: https://doi.org/10.5217/ir.2018.00013

Abstract PDF PubReader ePub

Background/Aims
We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer.
Methods
Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis.
Results
Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy.
Conclusions
Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy.

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The absolute number of small and diminutive adenomas with high-grade dysplasia is substantially higher compared with large adenomas: a retrospective pooled study
Jiancheng Zhang, Huajun Sun, Fei Xiong, Shan Lei, Guanyu Zhou, Xun Xiao, Lin Liu, Pu Wang
Frontiers in Oncology.2024;[Epub] CrossRef
A survey of current practices in post-polypectomy surveillance in Korea
Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Eun Ran Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoo
Intestinal Research.2024; 22(2): 186. CrossRef
Delineation of gastrointestinal tumors biopsies using a fluorescence lifetime imaging optical fiber probe
D. Suraci, E. Baria, L. Tirloni, J. L. Lagarto, S. Buccianti, C. Agostini, S. Pillozzi, L. Antonuzzo, A. Taddei, R. Cicchi
Journal of Biophotonics.2024;[Epub] CrossRef
Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection
Kwangwoo Nam, Jeong Eun Shin
The Korean Journal of Internal Medicine.2021; 36(2): 305. CrossRef

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Colorectal neoplasia

Clinical significance of carcinoembryonic antigen in peritoneal fluid detected during operation in stage I–III colorectal cancer patients: Jae Hyun Kim, Seunghun Lee, Seung Hyun Lee, Byung Kwon Ahn, Sung Uhn Baek, Won Moon, Seun Ja Park; Intest Res 2018;16(3):467-474. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.467

Abstract PDF PubReader ePub

Background/Aims

Early diagnosis of peritoneal metastases in patients with colorectal cancer (CRC) can influence patient prognosis. The aim of this study was to identify the clinical significance of carcinoembryonic antigen (CEA) in peritoneal fluid detected during operation in stage I–III CRC patients.

Methods

Between April 2009 and April 2015, we reviewed medical records from a total of 60 stage I–III CRC patients who had peritoneal fluid collected during operation. Patients who had positive cytology in the assessment of peritoneal fluid were excluded. We evaluated the values of CEA in peritoneal fluid (pCEA) to predict the long-term outcomes of these patients using Kaplan-Meier curves and Cox regression models.

Results

The median follow-up duration was 37 months (interquartile range, 21–50 months). On receiver operating characteristic analysis, pCEA had the largest area under the curve (0.793; 95% confidence interval, 0.635–0.950; P=0.001) with an optimal cutoff value of 26.84 (sensitivity, 80.0%; specificity, 76.6%) for predicting recurrence. The recurrence rate was 8.1% in patients with low pCEA (<26.84 ng/mL, n=37), and 52.2% in patients with high pCEA (≥26.84 ng/mL, n=23). In multivariate Cox regression analysis, high pCEA (≥26.84 ng/mL) was a risk factor for poor cancer-free survival (CFS) in stage I–III patients.

Conclusions

In this study, we determined that high pCEA (≥26.84 ng/mL) detected during operation was helpful for the prediction of poor CFS in patients with stage I–III CRC.

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Evaluation of peritoneal Carcinoembryonic Antigen as a survival prognostic factor in gastric cancer patients: a single western center experience
Nicola Natalizi, Elisabetta Marino, Luigina Graziosi, Annibale Donini
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Jing Jia, MinZhe Li, Wenhao Teng, Lin Wang, Weidong Zang, Jun Xiao, Ying Chen, Dan Zhao
Journal of Oncology.2021; 2021: 1. CrossRef

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Focused Review: Colorectal Cancers

Colorectal neoplasia

Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis: Soon Young Kim, Tae Il Kim; Intest Res 2018;16(3):358-365. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.358

Abstract PDF PubReader ePub

In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions via the alternative serrated neoplasia pathway. Major molecular alterations of sessile serrated neoplasia include BRAF mutation, high CpG island methylator phenotype, and escape of cellular senescence and progression via methylation of tumor suppressor genes or mismatch repair genes. With increasing information of the morphologic and molecular features of serrated lesions, one major challenge is how to reflect this knowledge in clinical practice, such as pathologic and endoscopic diagnosis, and guidelines for treatment and surveillance.

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Carol Rouphael, Jessica El Halabi, James Bena, John McMichael, Carol A. Burke
Clinical Gastroenterology and Hepatology.2024; 22(5): 1117. CrossRef
Serum DNA methylome of the colorectal cancer serrated pathway enables non‐invasive detection
María Gallardo‐Gómez, Lara Costas‐Ríos, Carlos A. Garcia‐Prieto, Lara Álvarez‐Rodríguez, Luis Bujanda, Maialen Barrero, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Antoni Tardío Baiges, Joaquín González‐Carreró Fojón, Joaquín Cubiel
Molecular Oncology.2024;[Epub] CrossRef
Different modifiable risk factors for the development of non-advanced adenoma, advanced adenomatous lesion, and sessile serrated lesions, on screening colonoscopy
A. Reum Choe, Eun Mi Song, Heeju Seo, Hyunju Kim, Gyuri Kim, Sojin Kim, Ju Ran Byeon, Yehyun Park, Chung Hyun Tae, Ki-Nam Shim, Sung-Ae Jung
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Colorectal neoplasia

Impact of microbiota in colorectal carcinogenesis: lessons from experimental models: Linda Chia-Hui Yu, Shu-Chen Wei, Yen-Hsuan Ni; Intest Res 2018;16(3):346-357. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.346

Abstract PDF PubReader ePub

A role of gut microbiota in colorectal cancer (CRC) growth was first suggested in germ-free rats almost 50 years ago, and the existence of disease-associated bacteria (termed pathobionts) had becoming increasingly evident from experimental data of fecal transplantation, and microbial gavage or monoassociation. Altered bacterial compositions in fecal and mucosal specimens were observed in CRC patients compared to healthy subjects. Microbial fluctuations were found at various cancer stages; an increase of bacterial diversity was noted in the adenoma specimens, while a reduction of bacterial richness was documented in CRC samples. The bacterial species enriched in the human cancerous tissues included Escherichia coli, Fusobacterium nucleatum, and enterotoxigenic Bacteroides fragilis. The causal relationship of gut bacteria in tumorigenesis was established by introducing particular bacterial strains in in situ mouse CRC models. Detailed experimental protocols of bacterial gavage and the advantages and caveats of different experimental models are summarized in this review. The microbial genotoxins, enterotoxins, and virulence factors implicated in the mechanisms of bacteria-driven tumorigenesis are described. In conclusion, intestinal microbiota is involved in colon tumorigenesis. Bacteria-targeting intervention would be the next challenge for CRC.

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Koki Hiura, Masaki Watanabe, Naoki Hirose, Kenta Nakano, Tadashi Okamura, Hayato Sasaki, Nobuya Sasaki
International Journal of Molecular Sciences.2024; 25(5): 3061. CrossRef
Association of gut microbiome with immune microenvironment in surgically treated colorectal cancer patients
Nayoung Han, Hee Jin Chang, Hyun Yang Yeo, Byung Chang Kim, Bun Kim, Sung Chan Park, Jeongseon Kim, Ji Won Park, Jae Hwan Oh
Pathology.2024; 56(4): 528. CrossRef
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Current Research in Nutrition and Food Science Journal.2024; 12(1): 20. CrossRef
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Adhari AlZaabi, Hussein A. Younus, Hassan A. Al-Reasi, Rashid Al-Hajri
Heliyon.2024; 10(16): e35935. CrossRef
Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer
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Journal of Advanced Research.2023; 52: 45. CrossRef
Tissue vs. Fecal-Derived Bacterial Dysbiosis in Precancerous Colorectal Lesions: A Systematic Review
Jurate Valciukiene, Kestutis Strupas, Tomas Poskus
Cancers.2023; 15(5): 1602. CrossRef
Human gene and microbial analyses in rectal cancer complete responses to radiotherapy
Arielle Kae Sulit, Kasmira Wilson, John Pearson, Olin K Silander, Shienny Sampurno, Michael Michael, Robert Ramsay, Alexander Heriot, Frank Frizelle, Rachel Violet Purcell
BJS Open.2023;[Epub] CrossRef
Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis
Ling Wang, Qing-Qing Zhang, Yu-Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni
Anti-Cancer Agents in Medicinal Chemistry.2023; 23(9): 1067. CrossRef
Gut microbiota and carcinogenesis: actual aspects
Aleksandr F. Poveshchenko, Valeria N. Cherkas, Aleksey V. Kabakov, Oleg V. Kazakov
Journal of microbiology, epidemiology and immunobiology.2023; 100(3): 247. CrossRef
Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms
Sang Hoon Kim, Dong Hwan Park, Yun Jeong Lim
The Korean Journal of Gastroenterology.2023; 82(2): 73. CrossRef
Risk Factors for Colorectal Polyps
嫣琦王
Advances in Clinical Medicine.2023; 13(09): 14803. CrossRef
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Sona Ciernikova, Aneta Sevcikova, Beata Mladosievicova, Michal Mego
Microorganisms.2023; 12(1): 24. CrossRef
Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses
Linda Chia-Hui Yu, Shu-Chen Wei, Yi-Hsuan Li, Po-Yu Lin, Xin-Yu Chang, Jui-Ping Weng, Yin-Wen Shue, Liang-Chuan Lai, Jin-Town Wang, Yung-Ming Jeng, Yen-Hsuan Ni
Cellular and Molecular Gastroenterology and Hepatology.2022; 13(1): 57. CrossRef
Epidemiology of Helicobacter pylori
Amnon Sonnenberg
Alimentary Pharmacology & Therapeutics.2022;[Epub] CrossRef
The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment
Sang Hoon Kim, Yun Jeong Lim
Intestinal Research.2022; 20(1): 31. CrossRef
Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora
Hourieh Sadrekarimi, Zhanna R. Gardanova, Morteza Bakhshesh, Farnoosh Ebrahimzadeh, Amirhossein Fakhre Yaseri, Lakshmi Thangavelu, Zahra Hasanpoor, Firoozeh Abolhasani Zadeh, Mohammad Saeed Kahrizi
Journal of Translational Medicine.2022;[Epub] CrossRef
The Potential Value of Gastric Histopathology for Predicting Colorectal Adenomatous Polyps Among the Chinese Population: A Retrospective Cross-Sectional Study
Weiwei Li, Lin Zhang, Yuanming Jing, Yanfei Yang, Yulong Wang
Frontiers in Oncology.2022;[Epub] CrossRef
The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review
Ida J. Malesza, Joanna Bartkowiak-Wieczorek, Jakub Winkler-Galicki, Aleksandra Nowicka, Dominika Dzięciołowska, Marta Błaszczyk, Paulina Gajniak, Karolina Słowińska, Leszek Niepolski, Jarosław Walkowiak, Edyta Mądry
Nutrients.2022; 14(17): 3478. CrossRef
Intratumoral microbiome and gastrointestinal cancers
Shengnan Li, Qian Li, Wei Lu
Frontiers in Oncology.2022;[Epub] CrossRef
Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients
Ciyan Chen, Min Niu, Junxi Pan, Na Du, Shumin Liu, Huanqin Li, Qiuyue He, Jian Mao, Yong Duan, Yan Du
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Biomedicines.2021; 9(2): 144. CrossRef
Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis
Antonio Biondi, Francesco Basile, Marco Vacante
World Journal of Gastrointestinal Oncology.2021; 13(6): 495. CrossRef
Microbiome and gastrointestinal malignancies
Ibrahim M Sayed, Haidi Karam-Allah Ramadan, Mohamed A El-Mokhtar, Lobna Abdel-Wahid
Current Opinion in Physiology.2021; 22: 100451. CrossRef
Effect of gut microbiome on minor complications after a colonoscopy
Jae Hyun Kim, Youn Jung Choi, Hye Jung Kwon, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
Intestinal Research.2021; 19(3): 341. CrossRef
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Sajeen Bahadur Amatya, Sonja Salmi, Veera Kainulainen, Peeter Karihtala, Justus Reunanen
Cancers.2021; 13(21): 5450. CrossRef
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High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients
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Digestion.2021; 102(6): 823. CrossRef
The Role of the Gut Microbiome in Colorectal Cancer: Where Are We? Where Are We Going?
Karina Wieczorska, Małgorzata Stolarek, Rafał Stec
Clinical Colorectal Cancer.2020; 19(1): 5. CrossRef
Fecal microbiota transplantation in disease therapy
Hanna Antushevich
Clinica Chimica Acta.2020; 503: 90. CrossRef
Associations between gastric histopathology and the occurrence of colonic polyps
A. Sonnenberg, K. O. Turner, R. M. Genta
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Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice
Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu
Journal of Immunology Research.2020; 2020: 1. CrossRef
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Greta Caprara, Paola Allavena, Marco Erreni
International Journal of Molecular Sciences.2020; 21(14): 4825. CrossRef
Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential
Ester Saus, Susana Iraola-Guzmán, Jesse R. Willis, Anna Brunet-Vega, Toni Gabaldón
Molecular Aspects of Medicine.2019; 69: 93. CrossRef
Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer
Thomas J Borody, Guy D Eslick, Robert L Clancy
Current Opinion in Pharmacology.2019; 49: 43. CrossRef
The association between fecal enterotoxigenic B. fragilis with colorectal cancer
Fakhri Haghi, Elshan Goli, Bahman Mirzaei, Habib Zeighami
BMC Cancer.2019;[Epub] CrossRef
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Experimental Cell Research.2019; 384(2): 111634. CrossRef
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Genes.2019; 10(11): 915. CrossRef
Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?
Niki Katsiki, Dimitri P. Mikhailidis, Christos Mantzoros
Metabolism.2018; 87: A10. CrossRef
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Linda Chia-Hui Yu
Journal of Biomedical Science.2018;[Epub] CrossRef

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Colorectal neoplasia

Intestinal microbiota, chronic inflammation, and colorectal cancer: Chan Hyuk Park, Chang Soo Eun, Dong Soo Han; Intest Res 2018;16(3):338-345. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.338

Abstract PDF PubReader ePub

In addition to genetic and epigenetic factors, various environmental factors, including diet, play important roles in the development of colorectal cancer (CRC). Recently, there is increasing interest in the intestinal microbiota as an environmental risk factor for CRC, because diet also influences the composition of the intestinal microbiota. The human intestinal microbiota comprises about 100 trillion microbes. This microbiome thrives on undigested dietary residues in the intestinal lumen and produces various metabolites. It is well known that the dietary risk factors for CRC are mediated by dysbiosis of the intestinal microbiota and their metabolites. In this review, we describe the bacterial taxa associated with CRC, including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, Escherichia coli, and butyrate-producing bacteria. We also discuss the host-diet interaction in colorectal carcinogenesis.

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Research Journal of Pharmacy and Technology.2024; : 2597. CrossRef
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Cancer Epidemiology.2024; 92: 102626. CrossRef
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International Journal of Molecular Sciences.2023; 24(4): 3665. CrossRef
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Matthew T. F. Lamaudière, Ramesh Arasaradnam, Gareth D. Weedall, Igor Y. Morozov, Vincent B. Young
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Da-Hye KANG, Sang-Hyeon YOO, Ju-Eun HONG, Ki-Jong RHEE
Korean Journal of Clinical Laboratory Science.2023; 55(1): 37. CrossRef
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Elena Moreno, Marius Trøseid, Ivan Vujkovic-Cvijin, Giulia Marchetti, Laura Martín-Pedraza, Sergio Serrano-Villar
Frontiers in Immunology.2023;[Epub] CrossRef
Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression
Jia-Jie Zhu, Hai-Yan Liu, Liang-Jun Yang, Zheng Fang, Rui Fu, Jia-Bin Chen, Shan Liu, Bao-Ying Fei
Journal of Medical Microbiology .2023;[Epub] CrossRef
Disease‐associated gut microbiome and critical metabolomic alterations in patients with colorectal cancer
Hongze Zhang, Kai Jin, Kunlong Xiong, Wenwen Jing, Zhen Pang, Meng Feng, Xunjia Cheng
Cancer Medicine.2023; 12(14): 15720. CrossRef
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Seminars in Cancer Biology.2022; 86: 666. CrossRef
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Kimia Ghasemi, Kosar Ghasemi
European Journal of Pharmacology.2022; 916: 174593. CrossRef
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Frontiers in Medicine.2022;[Epub] CrossRef
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The Korean Journal of Internal Medicine.2022; 37(5): 885. CrossRef
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Colorectal neoplasia

Genetic and epigenetic alterations of colorectal cancer: Sung Noh Hong; Intest Res 2018;16(3):327-337. Published online July 27, 2018; DOI: https://doi.org/10.5217/ir.2018.16.3.327

Abstract PDF PubReader ePub

Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC.

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Somayeh Igder, Mozhdeh Zamani, Shima Fakher, Morvarid Siri, Hassan Ashktorab, Negar Azarpira, Pooneh Mokarram, Sowjanya Thatikonda
Disease Markers.2024; 2024: 1. CrossRef
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Cells.2024; 13(14): 1195. CrossRef
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Clinical Epigenetics.2024;[Epub] CrossRef
Identification of an m6A‐related lncRNA prognostic signature in colorectal cancer
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Xiaoli He, Nan Wu, Renlong Li, Haohao Zhang, Yu Zhao, Yongzhan Nie, Jing Wu
Cellular Oncology.2023; 46(1): 145. CrossRef
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Molecular Biology Reports.2023; 50(2): 1385. CrossRef
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Molecular Omics.2023; 19(4): 283. CrossRef
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Byung Seok Cha, Young Jun Jang, Eun Sung Lee, Do Yeon Kim, Ji Su Woo, Jinseo Son, Seokjoon Kim, Jiye Shin, Jinjoo Han, Seokhwan Kim, Ki Soo Park
Advanced Healthcare Materials.2023;[Epub] CrossRef
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Frontiers in Oncology.2023;[Epub] CrossRef
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer
Ke Xu, Ai-Ru Yu, Shen-Bin Pan, Jie He
World Journal of Gastroenterology.2023; 29(36): 5240. CrossRef
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Saedeh Khadempar, Marzieh Lotfi, Fatemeh Haghiralsadat, Massoud Saidijam, Nasrin Ghasemi, Saeid Afshar
Computers in Biology and Medicine.2023; 166: 107518. CrossRef
Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
Humzah Postwala, Yesha Shah, Priyajeet S. Parekh, Mehul R. Chorawala
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World Journal of Gastroenterology.2022; 28(24): 2705. CrossRef
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Gastroenterology Report.2022;[Epub] CrossRef
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Frontiers in Oncology.2022;[Epub] CrossRef
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BMC Gastroenterology.2022;[Epub] CrossRef
Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance
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Frontiers in Oncology.2022;[Epub] CrossRef
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Colorectal neoplasia

A huge mass causing colonic obstruction at the hepatic flexure: Chang Hwi Yoon, Byoung Wook Bang, Kye Sook Kwon, Hyung Kil Kim, Yong Woon Shin; Intest Res 2018;16(2):323-324. Published online April 30, 2018; DOI: https://doi.org/10.5217/ir.2018.16.2.323

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Original Article

Colorectal neoplasia

An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer: Mohammed Faruk, Sani Ibrahim, Ahmed Adamu, Abdulmumini Hassan Rafindadi, Yahaya Ukwenya, Yawale Iliyasu, Abdullahi Adamu, Surajo Mohammed Aminu, Mohammed Sani Shehu, Danladi Amodu Ameh, Abdullahi Mohammed, Saad Aliyu Ahmed, John Idoko, Atara Ntekim, Aishatu Maude Suleiman, Khalid Zahir Shah, Kasimu Umar Adoke; Intest Res 2018;16(1):99-108. Published online January 18, 2018; DOI: https://doi.org/10.5217/ir.2018.16.1.99

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Background/Aims

Colorectal cancer (CRC) is now a major public health problem with heavy morbidity and mortality in rural Africans despite the lingering dietary fiber-rich foodstuffs consumption. Studies have shown that increased intake of dietary fiber which contribute to low fecal pH and also influences the activity of intestinal microbiota, is associated with a lowered risk for CRC. However, whether or not the apparent high dietary fiber consumption by Africans do not longer protects against CRC risk is unknown. This study evaluated dietary fiber intake, fecal fiber components and pH levels in CRC patients.

Methods

Thirty-five subjects (CRC=21, control=14), mean age 45 years were recruited for the study. A truncated food frequency questionnaire and modified Goering and Van Soest procedures were used.

Results

We found that all subjects consumed variety of dietary fiber-rich foodstuffs. There is slight preponderance in consumption of dietary fiber by the control group than the CRC patients. We also found a significant difference in the mean fecal neutral detergent fiber, acid detergent fiber, hemicellulose, cellulose and lignin contents from the CRC patients compared to the controls (P<0.05). The CRC patients had significantly more fecal pH level than the matched apparently healthy controls (P=0.017).

Conclusions

The identified differences in the fecal fiber components and stool pH levels between the 2 groups may relate to CRC incidence and mortality in rural Africans. There is crucial need for more hypothesis-driven research with adequate funding on the cumulative preventive role of dietary fiber-rich foodstuffs against colorectal cancer in rural Africans “today.”

Citations

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