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HOME > Intest Res > Volume 13(1); 2015 > Article
Review Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
Sung Hee Lee
Intestinal Research 2015;13(1):11-18.
DOI: https://doi.org/10.5217/ir.2015.13.1.11
Published online: January 29, 2015

Institute of Pharmaceutical Research and Development, Wonkwang University College of Pharmacy; BK21plus program & Department of Smart Life-Care Convergence, Wonkwang University Graduate School, Iksan, Korea.

Correspondence to Sung Hee Lee, Wonkwang University College of Pharmacy, 460 Iksan-daero, Iksan, Jeollabuk-do 570-749, Korea. Tel: +82-63-850-6820, Fax: +82-63-854-6038, gsseo@wku.ac.kr
• Received: August 18, 2014   • Revised: August 20, 2014   • Accepted: August 21, 2014

© Copyright 2015. Korean Association for the Study of Intestinal Diseases. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates the boundary between apical and basolateral membrane domains. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, which can act as a trigger for the development of intestinal and systemic diseases. Inflammatory bowel disease (IBD) patients demonstrate increased intestinal paracellular permeability. Although it remains unclear whether barrier dysfunction precedes disease or results from active inflammation, increased intestinal TJ disruption is observed in IBD patients suggest that dysregulation of TJ barrier integrity may predispose or enhance IBD progression. Therefore, therapeutic target to restore the TJ barrier integrity may provide effective therapeutic and preventive approaches against IBD. This review discusses the molecular structure and regulation of intestinal TJs and the involvement of intestinal TJs in IBD pathogenesis.
  • Keywords: Intestinal permeability; Tight junctions; Inflammatory bowel diseases; Intestinal barrier function; Paracellular permeability
Intestinal permeability is the property that allows solute and fluid exchange between the lumen and tissues. Conversely, intestinal barrier function refers to the ability of the mucosa and extracellular barrier components, such as mucus, to prevent this exchange.
A critical function of the intestinal epithelium is to form a barrier that prevents permeation of pro-inflammatory molecules, such as pathogens, toxins, and antigens, from the luminal environment into the mucosal tissues and circulatory system.1 Barrier defects have been associated with a variety of human diseases, including those primarily affecting the gut, such as IBD, celiac disease, and IBS, as well as systemic diseases or diseases involving other organ systems, such as type I diabetes, acquired immunodeficiency syndrome (AIDS), multiple sclerosis, and rheumatoid arthritis.2,3,4,5,6,7
Epithelial tight junctions (TJs) maintain the intestinal barrier while regulating permeability of ions, nutrients, and water. The TJ is a multi-protein complex that forms a selectively permeable seal between adjacent epithelial cells and demarcates the boundary between apical and basolateral membrane domains.8 The modification of TJ barrier function and paracellular permeability is dynamically regulated by various extracellular stimuli and is closely associated with our healthy and susceptibility disease.1,9 TJ barrier disruption and increased paracellular permeability, followed by permeation of luminal pro-inflammatory molecules, can induce activation of the mucosal immune system, resulting in sustained inflammation and tissue damage.
Evidence from basic science and clinical studies indicate that the intestinal TJ barrier has a critical role in the pathogenesis of intestinal and systemic diseases.1,10 Thus, this review summarizes the molecular structure and regulation of intestinal TJs and the involvement of intestinal TJs in IBD pathogenesis.
TJs are multiple protein complexes located at the apical ends of the lateral membranes of intestinal epithelial cells (Fig. 1).11,12 Four integral transmembrane proteins, occludin,13 claudins,14 junctional adhesion molecule (JAM),15 and tricelluin,16 have been identified. The intracellular domains of these transmemebrane proteins interact with cytosolic scaffold proteins, such as zonula occludens (ZO) proteins, which in turn anchor the transmembrane proteins to the actin cytoskeleton. The interaction of TJ proteins with the actin cytoskeleton is vital to the maintenance of TJ structure and permits the cytoskeletal regulation of TJ barrier integrity.17 The circumferential contraction and tension in the actin is regulated by myosin light chain (MLC) activation.18 Induction of MLC phosphorylation by kinases such as MLC kinase (MLCK) and Rho-associated kinase causes the contraction of the actin, resulting in the opening of the paracellular pathways.18,19
1. Occludin
Occludin was the first integral membrane TJ protein.13 The long C-terminal domain of occludin interacts with several intracellular TJ proteins, such as ZO proteins, which are required to link occludin to the actin cytoskeleton (Fig. 2).20 The function of occludin is not yet fully understood, but numerous studies using animals and cell cultures indicate that it has crucial roles in the TJ structure and permeability in the intestinal epithelia.21
Recent studies showed that knockdown of occludin induces an increase in paracellular permeability to macromolecules, which indicates that occludin plays a role in the maintenance and assembly of TJs.21 In the intact epithelium, occludin is highly phosphorylated on the serine and threonine residues,22 and the phosphorylation has a role in the maintenance and assembly of the TJ structure.23 Some kinases, such as protein kinase C (PKC) and casein kinase, have been identified as responsible for its phosphorylation.24,25 In addition, although the level of tyrosine-phosphorylated occludin is very low in the intact epithelium, several studies have shown that tyrosine phosphorylation is caused during disassembly by various stimuli.26
Underlying this mechanism, the tyrosine phosphorylation of occludin attenuates the interaction with ZO-1, leading to dissociation from the junctional complex. Like hydrogen peroxide, acetaldehyde, a biological metabolite of ethanol, also induces TJ disruption in intestinal epithelial cells in an occludin tyrosine phosphorylation-dependent manner.27
2. Claudins
Claudins do not have any sequence similarity to occludin. The extracellular loops of claudin molecules make hemophilic and heterophilic interactions with adjacent cells and the interactions create either barriers against or pores for the passage of selective molecules in the paracellular pathways.12,28 Numerous studies have demonstrated that claudins are the key component and backbone of TJs. When claudins are expressed in fibroblast, they are incorporated into TJ strands and form paired strands at the cell-cell contacts.14
Recent studies using claudin knockout mice have shown that claudins play a critical role in barrier formation and paracellular permeable selectivity in various tissues.29 As a prominent example, claudin-1 knockout mice die within 24 hours of birth because of a dramatic loss of fluid and electrolytes through the impaired epidermal barrier. Claudins are a multigene family with at least 24 members in humans and mice, and each isoform shows a unique expression pattern in tissues and cell lines. As is the case with occludin, some claudin isoforms are phosphorylated in the cells,30 and this phosphorylation is associated with localization and paracellular permeability.
3. Junctional Adhesion Molecule
The JAM family belongs to the Ig superfamily and is characterized by 2 extracellular Ig domains, one transmembrane domain, and one intracellular C-terminal domain.31 The extracellular N-terminal domains of the JAM family members bind to various ligands through hemophilic and heterophilic interactions.32 The hemophilic interactions involving the JAM members have a role in the formation of TJs and the cell-cell border. In contrast, the heterophilic interactions function in cell-cell adhesion, association between leukocytes and epithelial/endothelial cells, platelet activation, and virus recognition.
JAM members are expressed in various cell types including epithelial, endothelial, and immune cells, and exhibit different expression patterns in both a tissue- and cell type-specific manner. In intestinal epithelial cells, JAM-A and JAM-4 are expressed and involved in TJ regulation. In vitro and in vivo studies demonstrate that JAM-A participates in the regulation and maintenance of the TJ barrier. Treatment of intestinal epithelial cells with monoclonal JAM-A antibodies inhibited the resealing of the TJs, as indicated by delays in transepithelial electrical resistance (TER) recovery and occludin assembly.33 Recent studies have shown that JAM-A knockout mice exhibit higher permeability to dextran and myeloperoxidase activity in the colon compared to wild type mice. In addition, the colonic injury and inflammation induced by dextran sodium sulfate are more severe in the JAM-A knockout mice than in wild type mice.34
4. Zonula Occludens
The ZO proteins were the first TJ-specific proteins identified and three ZO proteins, ZO-1, -2, and -3, have been identified to date.35 According to sequence analysis, these ZO proteins are categorized as members of the membrane-associated guanylate kinase homolog family.17 They are multi-domain proteins carrying three post-synaptic density 95/Drosophila disc large/zona-occludens (PDZ) domains, a Src homology-3 domain and a region of homology to guanylate kinase homolog from the side of the N-terminus (Fig. 2).36 These multi-domain structures provide an intracellular scaffold in the TJs and are required for regulation and maintenance of TJ structure.
Interestingly, many TJ proteins bind to the N-terminal half region of ZO proteins, while the C-terminal region interacts with the actin cytoskeleton and cytoskeleton-associated proteins.37 Among the ZO proteins, the biochemical function and property of ZO-1 have been well examined. ZO-1 localizes to the nascent cell-cell contacts in both cell cultures and animal models. Therefore, it has been proposed that ZO proteins may mediate the early assembly of TJ proteins into cell-cell contacts. To data, intensive efforts have been made to clarify the functional role of ZO proteins, but it has been difficult to obtain clear evidence showing the importance of ZO proteins in TJ regulation. Recent studies have been shown that ZO-1 deficient cells are still able to form normal TJ structures and show normal permeability; however, an obvious delay in the assembly of other TJ proteins including occludin and claudins into the TJ is observed, indicating that the ZO proteins have an important role in the regulation of TJ assembly.38
The roles of cytokines in intestinal TJ regulation under pathophysiological conditions have been well investigated. The cytokine-mediated dysfunction of the TJ barrier, resulting in immune activation and tissue inflammation, is thought to be important in the initiation and/or development of several intestinal and systemic diseases.1,10 In contrast, some growth factors play roles in protection and maintenance of TJ integrity.
1. Interferon-γ
Interferon-γ (IFN-γ) is mainly involved in the regulation of inflammatory immune responses, and levels are elevated in the intestinal mucosa in patients with IBD.39 Recent studies have also demonstrated that IFN-γ increases paracellular permeability in intestinal epithelial cells through the redistribution and expression of TJ proteins and the rearrangement of the actin cytoskeleton.40 Thus, IFN-γ increases actinmyosin contractility in a Rho-associated kinase-dependent manner and induces TJ protein internalization, resulting in intestinal TJ disruption.
2. Tumor Necrosis Factor-α
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that is produced mainly by activated T cells and macrophages. Clinical studies show that TNF-α is elevated in the intestinal mucosa, serum, and stools of IBD patients. TNF-α is known to induce apoptosis and inflammatory response in intestinal epithelial cells,41 and recent studies have also demonstrated that it impairs the intestinal TJ barrier through different mechanism. In intestinal Caco-2 cells, MLCK expression, which has an important role in TJ regulation, was interrelated with the TNF-α-induced barrier defect. The TNF-α-induced decrease in TER is well correlated with MLCK expression and MLC phosphorylation.42 In addition, in intestinal HT-29/B6 cells, TNF-α was seen to decrease TER through claudin-2 expression.43 Claudin-2 is expressed throughout the intestine and forms a pore for cations, which is blocked by involvement of phosphatidyl inositol-3 kinase (PI3K)/Akt signaling.
3. Interleukin-1β
Interleukin-1β (IL-1β) is markedly elevated in intestinal mucosa under inflammatory conditions, such as CD patients.44 In clinical studies, an IL-1 receptor antagonist is currently being developed for therapeutic usage, which indicates IL-1β plays a central role in the intestinal inflammatory process.45 Furthermore, recent studies show that IL-1β causes increased intestinal TJ permeability. In intestinal Caco-2 cells, IL-1β decreases TER and increases inulin flux, which is in part mediated by the decreased expression and redistribution of occludin and increased expression of MLCK and MLC phosphorylation.46 It was also shown that the knockdown of nuclear factor-κB p65 inhibits the decrease in occludin and increases in MLCK expression, indicating nuclear factor-κB-dependent transcriptional regulation by IL-1β.47
4. Interleukin-6
The major source of interleukin-6 (IL-6) seen in IBD has been shown to be intestinal epithelial cells and lamina propria mononuclear cells.48 Recent studies indicate the involvement of IL-6 in intestinal TJ regulation.49 IL-6 increases paracellular permeability selectively to cations, but not to macromolecules, with an increase in pore-forming claudin-2 in intestinal epithelial cells, which requires the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and PI3K/Akt signaling activations.
5. Interleukin-10
Interleukin-10 (IL-10) is regarded as an anti-inflammatory cytokine. In vitro studies have demonstrated that IL-10 opposes the cellular functions induced by TNF-α and IFN-γ.50 IL-10 knockout mice, which are widely used as a model of spontaneous colitis, show increased intestinal permeability with elevated TNF-α, IL-1β, and IL-6 expression prior to exhibiting histologic signs of intestinal inflammation.51 These observations suggest that IL-10 has a role in the protection of the intestinal barrier. Clinical and animal studies have demonstrated that a major physiological consequence of total parenteral nutrition is the loss of intestinal barrier integrity.52 Mice administrated with total parenteral nutrition show increased intestinal paracellular permeability and decreased levels of TJ proteins, which is reversed by IL-10 treatment.53 Collectively, IL-10 restores the intestinal barrier defect.
6. Interleukin-17
Interleukin-17 (IL-17) is mainly produced in Th17 cells, potently induces tissue inflammation, and is associated with the pathogenesis a variety of autoimmune conditions, including rheumatoid arthritis, multiple sclerosis, and IBD.54 Information regarding intestinal barrier regulation by IL-17 is limited, but one study has demonstrated that IL-17 induces claudin expression.55 In intestinal T84 cells, IL-17 increases 2 claudin isoforms, claudin-1 and -2, which have opposing effects on TJ integrity. The MEK pathway is involved in IL-17-induced claudin-2 expression, but not claudin-1 expression.
7. Epidermal Growth Factor
Epidermal growth factor (EGF) is initially synthesized as a precursor transmembrane protein, and the mature and soluble form is released by proteolytic cleavage. The EGF receptor is expressed on the membrane surface of most cell types, and EGF mediates various biological functions, including cellular proliferation, differentiation, and survival through the receptor. Further, recent studies have shown that EGF protects intestinal barrier function against noxious stimuli including oxidative stress, ethanol, and acetaldehyde.56 EGF is known to activate several signaling pathways such as PKC and mitogen-activated protein kinase. The activation of the MEK/ERK pathway seems to be required for the EGF-mediated protection of the intestinal barrier against the oxidative stress. Acetaldehyde also disrupts barrier function, which is inhibited by pretreatment of EGF through the activation of EGF receptor-phospholipase-γ-PKCβ1/ε and EGF receptor-MEK/ERK signaling pathways.57
8. Transforming Growth Factor-β
Transforming growth factor-β (TGF-β) is a highly pleiotropic cytokine and proposed to act as a cellular switch to regulate immune function, proliferation, and epithelial mesenchymal transition. Several studies have demonstrated that TGF-β has protective or promotive effects on intestinal barrier function.58 In intestinal T84 cells, TGF-β increases the basal TER, which is mediated by claudin-1 expression through MEK/ERK signaling. In contrast, TGF-β protects the intestinal TJ barrier against noxious stimuli including cryptosporidium parvum and enterohemorrhagic Escherichia coli. In T84 cells, enterohemorrhagic E. coli disrupts the TJ barrier by disturbing the expression and distribution of TJ proteins, including ZO-1, caludin-2, and occludin, which is attenuated by pre-treatment of TGF-β.
IBD, including UC and CD, are chronic and relapsingremitting inflammatory diseases. Although the exact cause of IBD remains unknown, genetic susceptibility, environmental factors, and immune dysregulation all contribute to disease pathogenesis. In addition, IBD patients demonstrate increased intestinal paracellular permeability, which reflects decreased epithelial barrier function in IBD.59 Clinical studies show decreased expression and redistribution of barrierforming proteins, including occludin, claudin-3, -5, -8, and JAM-A, and increased expression of pore-forming claudin-2 in CD patients.60,61 In UC patients, decreased expression and redistribution of occludin, claudin-1, -4, and JAM-A, and increased caludin-2 expression are observed.61 In addition, MLCK expression and MLC phosphorylation are also observed in the intestines of both UC and CD patients, indicating that cytoskeletal dysregulation is involved in the increased intestinal permeability of IBD patients.62
Clinical studies show that the levels of inflammatory cytokines, including TNF-α,63 IFN-γ,39 IL-1β,44 IL-6,64 and IL-1754 are elevated in the intestines of IBD patients. As described above, these cytokines are known to disturb intestinal barrier function. In particular, TNF-α may have an important role in the initiation and development of intestinal barrier defects in IBD, because anti-TNF-α treatment suppresses the inflammatory response and improves intestinal permeability.65 As a consequence of perturbation of multiple cytokines, the alterations to the intestinal TJ structures in IBD patients could be complicated. In intestinal HT-29/B6 cells, TNF-α treatment resulted in decreased TJ strand number and complexity and increased frequency of strand breaks.66 TNF-α also inhibits occludin promoter activity43 and causes redistribution of occludin, ZO-1, and claudin-1.67 In vitro and in vivo, transcription and translation of MLCK, the major effector responsible for TNF-α-induced TJ modulation, are increased by TNF-α.43,67,68 Other pro-inflammatory cytokines may also mediate barrier function through modulation of MLCK activity. Since represents a common effector used by multiple cytokines to modulate paracellular permeability, it might be an important target for further therapies to restore barrier function during active disease.
Epithelial barrier dysfunction and inflammation are major contributors to the pathogenesis intestinal disease. Intestinal TJ structures are organized by multiple integral proteins and signaling molecules. Clinical and experimental studies demonstrate that defects in the intestinal TJ barrier and increased permeability are observed in various intestinal and systemic diseases. Intestinal TJ barrier is dynamically regulated by cytokines and pathogens. Therefore, understanding the molecular mechanisms underlying TJ regulation by the extracellular factors will lead to the development of effective therapeutic and preventive approaches against diseases associated with intestinal barrier defects such as IBD.

Financial support: This study was supported by a grant from Wonkwang University 2013.

Conflict of interest: None.

  • 1. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9:799–809.PMID: 19855405.ArticlePubMedPDF
  • 2. van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 1993;34:354–357.PMID: 8472983.ArticlePubMedPMC
  • 3. Dunlop SP, Hebden J, Campbell E, et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 2006;101:1288–1294.PMID: 16771951.ArticlePubMed
  • 4. Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006;49:2824–2827.PMID: 17028899.ArticlePubMed
  • 5. Sharpstone D, Neild P, Crane R, et al. Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea. Gut 1999;45:70–76.PMID: 10369707.ArticlePubMedPMC
  • 6. Yacyshyn B, Meddings J, Sadowski D, Bowen-Yacyshyn MB. Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability. Dig Dis Sci 1996;41:2493–2498.PMID: 9011463.ArticlePubMed
  • 7. Martínez-González O, Cantero-Hinojosa J, Paule-Sastre P, Gómez-Magán JC, Salvatierra-Ríos D. Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives. Br J Rheumatol 1994;33:644–647.PMID: 8019793.ArticlePubMedPDF
  • 8. Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol 2006;169:1901–1909.PMID: 17148655.ArticlePubMedPMC
  • 9. Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 2000;279:G851–G857.PMID: 11052980.ArticlePubMed
  • 10. Farhadi A, Banan A, Fields J, Keshavarzian A. Intestinal barrier: an interface between health and disease. J Gastroenterol Hepatol 2003;18:479–497.PMID: 12702039.ArticlePubMed
  • 11. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001;2:285–293.PMID: 11283726.ArticlePubMedPDF
  • 12. Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol 2006;68:403–429.PMID: 16460278.ArticlePubMed
  • 13. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993;123:1777–1788.PMID: 8276896.ArticlePubMedPMC
  • 14. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998;141:1539–1550.PMID: 9647647.ArticlePubMedPMC
  • 15. Martín-Padura I, Lostaglio S, Schneemann M, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998;142:117–127.PMID: 9660867.ArticlePubMedPMC
  • 16. Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol 2005;171:939–945.PMID: 16365161.ArticlePubMedPMC
  • 17. González-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol 2003;81:1–44.PMID: 12475568.ArticlePubMed
  • 18. Turner JR, Rill BK, Carlson SL, et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 1997;273:C1378–C1385.PMID: 9357784.ArticlePubMed
  • 19. Walsh SV, Hopkins AM, Chen J, Narumiya S, Parkos CA, Nusrat A. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 2001;121:566–579.PMID: 11522741.ArticlePubMed
  • 20. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 1994;127:1617–1626.PMID: 7798316.ArticlePubMedPMC
  • 21. Al-Sadi R, Khatib K, Guo S, Ye D, Youssef M, Ma T. Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2011;300:G1054–G1064.PMID: 21415414.ArticlePubMedPMC
  • 22. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 1997;137:1393–1401.PMID: 9182670.ArticlePubMedPMC
  • 23. Rao R. Occludin phosphorylation in regulation of epithelial tight junctions. Ann N Y Acad Sci 2009;1165:62–68.PMID: 19538289.ArticlePubMedPMC
  • 24. Jain S, Suzuki T, Seth A, Samak G, Rao R. Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions. Biochem J 2011;437:289–299.PMID: 21545357.ArticlePubMedPMC
  • 25. McKenzie JA, Riento K, Ridley AJ. Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett 2006;580:2388–2394.PMID: 16616143.ArticlePubMed
  • 26. Elias BC, Suzuki T, Seth A, et al. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem 2009;284:1559–1569.PMID: 19017651.ArticlePubMedPMC
  • 27. Atkinson KJ, Rao RK. Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am J Physiol Gastrointest Liver Physiol 2001;280:G1280–G1288.PMID: 11352822.ArticlePubMed
  • 28. Tsukita S, Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol 2000;149:13–16.PMID: 10747082.ArticlePubMedPMC
  • 29. Tamura A, Hayashi H, Imasato M, et al. Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology 2011;140:913–923.PMID: 20727355.ArticlePubMed
  • 30. Fujibe M, Chiba H, Kojima T, et al. Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res 2004;295:36–47.PMID: 15051488.ArticlePubMed
  • 31. Cunningham SA, Arrate MP, Rodriguez JM, et al. A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. J Biol Chem 2000;275:34750–34756.PMID: 10945976.ArticlePubMed
  • 32. Bazzoni G. The JAM family of junctional adhesion molecules. Curr Opin Cell Biol 2003;15:525–530.PMID: 14519386.ArticlePubMed
  • 33. Liu Y, Nusrat A, Schnell FJ, et al. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 2000;113:2363–2374.PMID: 10852816.ArticlePubMedPDF
  • 34. Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med 2007;204:3067–3076.PMID: 18039951.ArticlePubMedPMC
  • 35. Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol 1998;141:199–208.PMID: 9531559.ArticlePubMedPMC
  • 36. Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc Natl Acad Sci U S A 1993;90:7834–7838.PMID: 8395056.ArticlePubMedPMC
  • 37. Fanning AS, Ma TY, Anderson JM. Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1. FASEB J 2002;16:1835–1837.PMID: 12354695.ArticlePubMed
  • 38. Umeda K, Matsui T, Nakayama M, et al. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem 2004;279:44785–44794.PMID: 15292177.ArticlePubMed
  • 39. Stallmach A, Giese T, Schmidt C, Ludwig B, Mueller-Molaian I, Meuer SC. Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease. Int J Colorectal Dis 2004;19:308–315.PMID: 14605835.ArticlePubMed
  • 40. Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A. Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 2005;19:923–933.PMID: 15923402.ArticlePubMed
  • 41. Schulzke JD, Bojarski C, Zeissig S, Heller F, Gitter AH, Fromm M. Disrupted barrier function through epithelial cell apoptosis. Ann N Y Acad Sci 2006;1072:288–299.PMID: 17057208.ArticlePubMed
  • 42. Ma TY, Boivin MA, Ye D, Pedram A, Said HM. Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 2005;288:G422–G430.PMID: 15701621.ArticlePubMed
  • 43. Mankertz J, Amasheh M, Krug SM, et al. TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tissue Res 2009;336:67–77.PMID: 19214581.ArticlePubMed
  • 44. Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J 1994;8:1314–1325.PMID: 8001745.ArticlePubMed
  • 45. Barksby HE, Lea SR, Preshaw PM, Taylor JJ. The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol 2007;149:217–225.PMID: 17590166.ArticlePubMedPMC
  • 46. Al-Sadi R, Ye D, Dokladny K, Ma TY. Mechanism of IL-1β-induced increase in intestinal epithelial tight junction permeability. J Immunol 2008;180:5653–5661.PMID: 18390750.ArticlePubMedPMC
  • 47. Al-Sadi R, Ye D, Said HM, Ma TY. IL-1β-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-κB pathway. Am J Pathol 2010;177:2310–2322.PMID: 21048223.ArticlePubMedPMC
  • 48. Kusugami K, Fukatsu A, Tanimoto M, et al. Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent. Dig Dis Sci 1995;40:949–959.PMID: 7729284.ArticlePubMed
  • 49. Suzuki T, Yoshinaga N, Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 2011;286:31263–31271.PMID: 21771795.ArticlePubMedPMC
  • 50. Kucharzik T, Lugering N, Pauels HG, Domschke W, Stoll R. IL-4, IL-10 and IL-13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells. Clin Exp Immunol 1998;111:152–157.PMID: 9472675.ArticlePubMedPMC
  • 51. Madsen KL, Malfair D, Gray D, Doyle JS, Jewell LD, Fedorak RN. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis 1999;5:262–270.PMID: 10579119.ArticlePubMed
  • 52. Kansagra K, Stoll B, Rognerud C, et al. Total parenteral nutrition adversely affects gut barrier function in neonatal piglets. Am J Physiol Gastrointest Liver Physiol 2003;285:G1162–G1170.PMID: 12969831.ArticlePubMed
  • 53. Sun X, Yang H, Nose K, et al. Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 2008;294:G139–G147.PMID: 17991705.ArticlePubMed
  • 54. Pappu R, Ramirez-Carrozzi V, Sambandam A. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology 2011;134:8–16.PMID: 21726218.ArticlePubMedPMC
  • 55. Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000;118:1001–1011.PMID: 10833473.ArticlePubMed
  • 56. Basuroy S, Seth A, Elias B, Naren AP, Rao R. MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Biochem J 2006;393:69–77.PMID: 16134968.ArticlePubMed
  • 57. Samak G, Aggarwal S, Rao RK. ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers. Am J Physiol Gastrointest Liver Physiol 2011;301:G50–G59.PMID: 21474650.ArticlePubMedPMC
  • 58. Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-β regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. Am J Pathol 2005;167:1587–1597.PMID: 16314472.ArticlePubMedPMC
  • 59. Söderholm JD, Peterson KH, Olaison G, et al. Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease. Gastroenterology 1999;117:65–72.PMID: 10381911.ArticlePubMed
  • 60. Zeissig S, Bürgel N, Günzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007;56:61–72.PMID: 16822808.ArticlePubMed
  • 61. Vetrano S, Rescigno M, Cera MR, et al. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 2008;135:173–184.PMID: 18514073.ArticlePubMed
  • 62. Blair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest 2006;86:191–201.PMID: 16402035.ArticlePubMedPDF
  • 63. Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993;34:1705–1709.PMID: 8031350.ArticlePubMedPMC
  • 64. Louis E, Belaiche J, van Kemseke C, et al. A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease. Eur J Gastroenterol Hepatol 1997;9:939–944.PMID: 9391781.ArticlePubMed
  • 65. Suenaert P, Bulteel V, Lemmens L, et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol 2002;97:2000–2004.PMID: 12190167.ArticlePubMed
  • 66. Schmitz H, Fromm M, Bentzel CJ, et al. Tumor necrosis factor-alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 1999;112(Pt 1): 137–146.PMID: 9841910.ArticlePubMedPDF
  • 67. Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR. Interferon-γ and tumor necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 2005;166:409–419.PMID: 15681825.ArticlePubMedPMC
  • 68. Graham WV, Wang F, Clayburgh DR, et al. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem 2006;281:26205–26215.PMID: 16835238.ArticlePubMed
Fig. 1
Molecular structure of the intracellular junction of intestinal epithelial cells. The tight junctions (TJs), multiple protein complexes, locate at the apical ends of the lateral membranes of intestinal epithelial cells. The TJ complex consists of transmembrane and intracellular scaffold proteins. The transmembrane proteins (claudins, occludin, and junctional adhesion molecules [JAMs]) create a permselective barrier in the paracellular pathways. The intracellular domains of the transmembrane proteins interact with the intracellular scaffold proteins such as zonula occludens (ZO) proteins, which in turn anchor the transmembrane proteins to the actin cytoskeleton.
ir-13-11-g001.jpg
Fig. 2
Interaction of proteins with the integral scaffold tight junction (TJ) proteins, zonula occludens (ZO)-1, -2, and -3. ZO proteins carry 3 post-synaptic density 95/Drosophila disc large/zona-occludens (PDZ) domains, a Src homology-3 (SH3) domain, and a region of homology to guanylate kinase (GUK) from the side of the N-terminus. Several TJ proteins and cytoskeletal actin interact with the ZO proteins. JAM-A, junctional adhesion molecule-A.
ir-13-11-g002.jpg

Figure & Data

REFERENCES

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    Citations to this article as recorded by  
    • Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders
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      Neuroscience.2025; 565: 99.     CrossRef
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      Jyotsana Bakshi, K.P. Mishra
      Cellular Immunology.2025; 408: 104912.     CrossRef
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      Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
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      Ding Wang, Qi Jiang, Ruoyu Shen, Lijun Peng, Wentao Zhou, Tingting Meng, Fuqiang Hu, Jianwei Wang, Hong Yuan
      Nano Research.2024; 17(6): 5409.     CrossRef
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      Journal of Agricultural and Food Chemistry.2024; 72(8): 4142.     CrossRef
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      Frontiers in Microbiology.2024;[Epub]     CrossRef
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      Ecotoxicology and Environmental Safety.2024; 282: 116750.     CrossRef
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      Experimental and Therapeutic Medicine.2024;[Epub]     CrossRef
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      Sasa Miao, Jiankui Li, Ying Chen, Wenyan Zhao, Mengru Xu, Fang Liu, Xiaoting Zou, Xinyang Dong
      Animal Nutrition.2024; 19: 104.     CrossRef
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      Yanni Li, Yaoyu Guo, Chong Geng, Shuailing Song, Wenjuan Yang, Xiao Li, Chunhui Wang
      Frontiers in Pharmacology.2024;[Epub]     CrossRef
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      Marinella Pinelli, Stephanie Makdissi, Michal Scur, Brendon D. Parsons, Kristi Baker, Anthony Otley, Brad MacIntyre, Huong D. Nguyen, Peter K. Kim, Andrew W. Stadnyk, Francesca Di Cara
      Cell Death & Disease.2024;[Epub]     CrossRef
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      Hyeon Jae Lee, Kyeong Jin Kim, Soo-yeon Park, Kwanyong Choi, Jaeho Pyee, Sunyong Yoo, Ji Yeon Kim
      Food Bioscience.2024; 61: 104833.     CrossRef
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      Jennifer G. Nwako, Heather A. McCauley
      Molecular and Cellular Endocrinology.2024; : 112339.     CrossRef
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      Hideaki Yokoyama, Taku Masuyama, Yuki Tanaka, Taishi Shimazaki, Yuzo Yasui, Takuya Abe, Kouichi Yoshinari
      Toxicology Letters.2024; 400: 16.     CrossRef
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      Peishan Qiu, Kezhi Zhou, Youwei Wang, Xiaoyu Chen, Cong Xiao, Wenjie Li, Yuhua Chen, Ying Chang, Jing Liu, Feng Zhou, Xiaobing Wang, Jian Shang, Lan Liu, Zhao Qiu
      American Journal of Physiology-Gastrointestinal and Liver Physiology.2024; 327(3): G317.     CrossRef
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      Small Structures.2024;[Epub]     CrossRef
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      Lingling Yuan, Yingyi Wang, Na Li, Xuli Yang, Xuhui Sun, Huai’e Tian, Yi Zhang
      Antioxidants.2024; 13(8): 1012.     CrossRef
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      Pengkui Xia, Ruyi Li, Mianhong Chen, Fanke Zeng, Wei Zhou, Tao Hou
      Journal of Agricultural and Food Chemistry.2024; 72(35): 19366.     CrossRef
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      Vignesh B. Nathan, Sarah Eckrote, Shiyu Li, Lavanya Reddivari
      Antioxidants.2024; 13(9): 1044.     CrossRef
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      Annals of Animal Science.2024;[Epub]     CrossRef
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    • Dietary Fermented Blueberry Pomace Supplementation Improves Small Intestinal Barrier Function and Modulates Cecal Microbiota in Aged Laying Hens
      Binghua Qin, Zhihua Li, Qian Zhu, Ting Chen, Wei Lan, Yadong Cui, Md. Abul Kalam Azad, Xiangfeng Kong
      Animals.2024; 14(19): 2786.     CrossRef
    • Human Amniotic Epithelial Stem Cells Promote Colonic Recovery in Experimental Colitis via Exosomal MiR‐23a–TNFR1–NF‐κB Signaling
      Yaohui Kou, Jinying Li, Yingyi Zhu, Jia Liu, Ruizhe Ren, Yuanqing Jiang, Yunyun Wang, Chen Qiu, Jiayi Zhou, Zhuoheng Yang, Tuoying Jiang, Jianan Huang, Xiangyi Ren, Shiguang Li, Cong Qiu, Xiyang Wei, Luyang Yu
      Advanced Science.2024;[Epub]     CrossRef
    • Comparative analysis of bisphenol A effects on HT-29 cell line and mouse intestinal organoids
      Eunju Jang, Changhwan Ahn
      Journal of Biomedical Translational Research.2024; 25(3): 107.     CrossRef
    • Overcoming Biopotency Barriers: Advanced Oral Delivery Strategies for Enhancing the Efficacy of Bioactive Food Ingredients
      Ling Liu, David Julian McClements, Xuebo Liu, Fuguo Liu
      Advanced Science.2024;[Epub]     CrossRef
    • The Effect of CKD-495, Eupacidin, and Their Marker Compounds on Altered Permeability in a Postoperative Ileus Animal Model
      Min-Jae Kim, Zahid Hussain, Young Ju Lee, Hyojin Park
      Medicina.2024; 60(10): 1707.     CrossRef
    • Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice
      Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
      Food & Function.2024; 15(22): 10987.     CrossRef
    • Farnesol ameliorates DSS-induced IBD by regulating inflammatory cytokines, repairing the intestinal barrier, reversing the gut microbiota imbalance, and influencing fecal metabolome in C57BL/6 mice
      Ya Yuan, Dazuo Wu, Heping Chen, Zheng Ma, Xinyue Peng, Xiaodie Li, Chuchu Zhao, Linping Jiang, Jinping Liang, Weiwei Zhang, Juan Dai
      Biomedicine & Pharmacotherapy.2024; 180: 117518.     CrossRef
    • Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review
      Xinyu Li, Riran Zhu, Qian Liu, Henglai Sun, Huagang Sheng, Liqiao Zhu
      International Journal of Biological Macromolecules.2024; 282: 136691.     CrossRef
    • Dietary ω-3 Fatty Acids Mitigate Intestinal Barrier Integrity Alterations in Mice Fed a High-Fat Diet: Implications for Pancreatic Carcinogenesis
      Jazmin Machuca, Joanna Wirkus, Aya S Ead, Payam Vahmani, Karen E Matsukuma, Gerardo G Mackenzie, Patricia I Oteiza
      The Journal of Nutrition.2024;[Epub]     CrossRef
    • Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease
      Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig
      Advanced Healthcare Materials.2024;[Epub]     CrossRef
    • Natural plant polyphenols contribute to the ecological and healthy swine production
      Huadi Mei, Yuanfei Li, Shusong Wu, Jianhua He
      Journal of Animal Science and Biotechnology.2024;[Epub]     CrossRef
    • Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity
      Sang Un Kim, Ji A Choi, Man-Hoon Han, Jin Young Choi, Ji Hye Park, Moon Sik Kim, Yong Hwan Kwon
      The Korean Journal of Internal Medicine.2024; 39(6): 906.     CrossRef
    • Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon Through the Acetate/Propionate‐GPR41‐Gβγ Pathway
      Yin Huang, Nan Tang, Yifan Xue, Jiazhen Li, WenXu Liu, Shengnan Zhu, Linlin Wang, Gang Wang, Wei Chen, Jianxin Zhao
      Food Frontiers.2024;[Epub]     CrossRef
    • Biocompatible carbon dots nanozymes as ROS/RNS modulators for ulcerative colitis alleviation by comprehensively orchestrating intestinal homeostasis
      Wenjing Wang, Guangrong Lu, Zhichao Deng, Huanyu Li, Wenfang He, Shouxing Yang, Yuanyuan Zhu, Chenxi Xu, Yujie Zhang, Lanqi Wang, Xiaoling Huang, Mingzhen Zhang, Changlong Xu
      Chemical Engineering Journal.2024; 502: 157800.     CrossRef
    • Prevalence of bronchiectasis in inflammatory bowel disease: a systematic review and meta-analysis
      Yu Ma, Zhihui Qiang, Miaomiao Zhou, Tianyi Zhang, Zhuoyang Li, Haicheng Zhong, Yue Chang, Zimeng Ning, Yun Liu
      Frontiers in Medicine.2024;[Epub]     CrossRef
    • Cellular Plasticity in Gut and Liver Regeneration
      Minwook Kim, Yoojeong Park, You Sun Kim, Sungjin Ko
      Gut and Liver.2024; 18(6): 949.     CrossRef
    • The Leaky Gut and Human Diseases: “Can’t Fill the Cup if You Don’t Plug the Holes First”
      Debora Compare, Costantino Sgamato, Alba Rocco, Pietro Coccoli, Carmen Ambrosio, Gerardo Nardone
      Digestive Diseases.2024; 42(6): 548.     CrossRef
    • Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota
      Yijia Zhong, Xiujuan Chang, Zihan Zhao, Lijun Zheng, Gaobo Kuang, Ping Li, Chenxuexuan Liu, Yuqin Fan, Zhixuan Liang, Ke Zhuang, Qiuling Xie, Yangyang Liu
      Frontiers in Pharmacology.2024;[Epub]     CrossRef
    • Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases
      Jonathan Escalante, Olivia Artaiz, Shanti Diwakarla, Rachel M. McQuade
      GeroScience.2024;[Epub]     CrossRef
    • Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease
      Xingchao Zhu, Jiayu Wang, Huan Zhang, Hongqin Yue, Jinghan Zhu, Juntao Li, Kun Wang, Kanger Shen, Kexi Yang, Xia Leng, Qinhua Xi, Tongguo Shi
      Cellular and Molecular Life Sciences.2024;[Epub]     CrossRef
    • Effects of Dietary Supplementation with Lactobacillus acidophilus and Bacillus subtilis on Mucosal Immunity and Intestinal Barrier Are Associated with Its Modulation of Gut Metabolites and Microbiota in Late-Phase Laying Hens
      Xin Chen, Weiwen Chen, Wenjia Ci, Yingying Zheng, Xinyan Han, Jianping Huang, Jianjin Zhu
      Probiotics and Antimicrobial Proteins.2023; 15(4): 912.     CrossRef
    • Effects of Bacillus methylotrophicus SY200 Supplementation on Growth Performance, Antioxidant Status, Intestinal Morphology, and Immune Function in Broiler Chickens
      Dan Xiao, Zhenhua Wang, Xixi Dai, Yuanwei Hu, Maiyi Zhong, Lvchen Xiong, Chuanheng Jiang, Abdul Khalique, Xueqin Ni, Dong Zeng, Dongmei Zhang, Yan Zeng, Kangcheng Pan
      Probiotics and Antimicrobial Proteins.2023; 15(4): 925.     CrossRef
    • Diets Supplemented with Probiotics Improve the Performance of Broilers Exposed to Heat Stress from 15 Days of Age
      Jéssica C. das D. Ribeiro, Mariana M. Drumond, Pamela Mancha-Agresti, João P. F. Guimarães, Daiane da C. Ferreira, Maria I. A. Martins, Pedro M. de M. Murata, Andressa C. de Carvalho, Raquel T. Pereira, Valdir Ribeiro Júnior, Vasco A. de C. Azevedo, Lucia
      Probiotics and Antimicrobial Proteins.2023; 15(5): 1327.     CrossRef
    • Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome
      Arshia Shahini, Ali Shahini
      Journal of Cell Communication and Signaling.2023; 17(1): 55.     CrossRef
    • Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli
      Van Hieu Pham, Waseem Abbas, Jinyu Huang, Fangshen Guo, Kaichen Zhang, Linhua Kong, Wenrui Zhen, Yuming Guo, Zhong Wang
      Animal Nutrition.2023; 12: 245.     CrossRef
    • Paeoniflorin‐6′‐O‐benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β‐arrestin 2 on ERK1/2‐NF‐κB
      Mengya Jiang, Caihong Tang, Mei Yang, Ying Li, Wu Wang, Chun Wang, Wei Wei, Jingyu Chen
      Phytotherapy Research.2023; 37(2): 743.     CrossRef
    • Alleviative mechanism and effect of Bifidobacterium animalisA6 on dextran sodium sulfate‐induced ulcerative colitis in mice
      Fang Wu, Guna Wuri, Bing Fang, Mengxuan Shi, Ming Zhang, Liang Zhao
      Food Science & Nutrition.2023; 11(2): 892.     CrossRef
    • Anti-inflammatory mechanisms of polyphenols in adipose tissue: role of gut microbiota, intestinal barrier integrity and zinc homeostasis
      Tariful Islam, Kembra Albracht-Schulte, Latha Ramalingam, Natalia Schlabritz-Lutsevich, Oak-Hee Park, Masoud Zabet-Moghaddam, Nishan S. Kalupahana, Naima Moustaid-Moussa
      The Journal of Nutritional Biochemistry.2023; 115: 109242.     CrossRef
    • Effects of β-alanine on intestinal development and immune performance of weaned piglets
      Linlin Chen, Yan Zhong, Xiangqin Ouyang, Chunfeng Wang, Lanmei Yin, Jing Huang, Yali Li, Qiye Wang, Junyan Xie, Pengfei Huang, Huansheng Yang, Yulong Yin
      Animal Nutrition.2023; 12: 398.     CrossRef
    • Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition
      Yu Xia, Qihui Luo, Chao Huang, Liangqin Shi, Asad Jahangir, Ting Pan, Xiaoli Wei, Junbo He, Wentao Liu, Riyi Shi, Yi Geng, Jing Fang, Li Tang, Hongrui Guo, Ping Ouyang, Zhengli Chen
      Ecotoxicology and Environmental Safety.2023; 249: 114364.     CrossRef
    • Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis
      Kyung-Sook Chung, Sang-Eun Park, Jung-Hun Lee, Su-Yeon Kim, Hee-Soo Han, Yong Sup Lee, Seang-Hwan Jung, Eungyeong Jang, Sangmin Lee, Kyung-Tae Lee
      Chemico-Biological Interactions.2023; 370: 110316.     CrossRef
    • Intestinal mucosal and fecal microbiota profiles in Crohn's disease in Chinese children
      Peilin Wu, Bin Wu, Zehao Zhuang, Junhong Liu, Linliang Hong, Bihong Ma, Biyun Lin, Junxi Wang, Chenye Lin, Junhong Chen, Suqing Chen
      Medicine in Microecology.2023; 15: 100071.     CrossRef
    • Pingyin Rose Essential Oil Restores Intestinal Barrier Integrity in DSS-induced Mice Colitis Model
      Rifat Nowshin Raka, Junsong Xiao, Hua Wu, Wenwen Lv, Zhiqian Ding, Yangping Cao, Xukai Li, Jinglong Sun, Kou Luan
      Food Research International.2023; 164: 112362.     CrossRef
    • Protective effect of Paecilomyces cicadae TJJ11213 exopolysaccharide on intestinal mucosa and regulation of gut microbiota in immunosuppressed mice
      Juanjuan Tian, Xiaogan Zhao, Chao Tang, Xiaomeng Wang, Xueliang Zhang, Luyao Xiao, Wei Li
      Food Research International.2023; 165: 112477.     CrossRef
    • Dietary and phytogenic inclusion effects on the broiler chicken cecal ecosystem
      Irida Palamidi, Vasileios V. Paraskeuas, Konstantinos C. Mountzouris
      Frontiers in Animal Science.2023;[Epub]     CrossRef
    • Huangshui Polysaccharide Exerts Intestinal Barrier Protective Effects through the TLR4/MyD88/NF-κB and MAPK Signaling Pathways in Caco-2 Cells
      Jiaying Huo, Wenhao Pei, Guoying Liu, Weizheng Sun, Jihong Wu, Mingquan Huang, Wei Lu, Jinyuan Sun, Baoguo Sun
      Foods.2023; 12(3): 450.     CrossRef
    • IBD disease-modifying therapies: insights from emerging therapeutics
      Niranjan G. Kotla, Yury Rochev
      Trends in Molecular Medicine.2023; 29(3): 241.     CrossRef
    • Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality
      Jorge Parrón-Ballesteros, Rubén García Gordo, Juan Carlos López-Rodríguez, Nieves Olmo, Mayte Villalba, Eva Batanero, Javier Turnay
      Frontiers in Allergy.2023;[Epub]     CrossRef
    • Acute high-fat diet impairs macrophage-supported intestinal damage resolution
      Andrea A. Hill, Myunghoo Kim, Daniel F. Zegarra-Ruiz, Lin-Chun Chang, Kendra Norwood, Adrien Assié, Wan-Jung H. Wu, Michael C. Renfroe, Hyo Wong Song, Angela M. Major, Buck S. Samuel, Joseph M. Hyser, Randy S. Longman, Gretchen E. Diehl
      JCI Insight.2023;[Epub]     CrossRef
    • Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments
      Yaxi Zhou, Diandian Wang, Wenjie Yan
      Nutrients.2023; 15(4): 1031.     CrossRef
    • Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems
      Qasem Ramadan, Rana Hazaymeh, Mohammed Zourob
      Advanced Biology.2023;[Epub]     CrossRef
    • Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model
      Ayse Seda Erarslan, Recep Ozmerdivenli, Ferhat Sirinyıldız, Ozge Cevik, Erkan Gumus, Gokhan Cesur
      Toxicology Mechanisms and Methods.2023; 33(6): 480.     CrossRef
    • Prospective Use of Probiotics to Maintain Astronaut Health during Spaceflight
      Sahaj Bharindwal, Nidhi Goswami, Pamela Jha, Siddharth Pandey, Renitta Jobby
      Life.2023; 13(3): 727.     CrossRef
    • Gut microbiome and renal transplantation
      Patrícia Kleinová, Monika Beliančinová, Matej Vnučák, Karol Graňák, Ivana Dedinská
      Vnitřní lékařství.2023; 69(1): 41.     CrossRef
    • Coxsackie B – Pantropic Viruses
      Beata Gad, Magdalena Wieczorek
      Postępy Mikrobiologii - Advancements of Microbiology.2023; 62(1): 13.     CrossRef
    • Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies
      Vishnu Raj, Balaji Venkataraman, Shreesh K. Ojha, Saeeda Almarzooqi, Veedamali S. Subramanian, Basel K. Al-Ramadi, Thomas E. Adrian, Sandeep B. Subramanya
      Molecules.2023; 28(7): 2982.     CrossRef
    • Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice
      Qianjue Hu, Leilei Yu, Qixiao Zhai, Jianxin Zhao, Fengwei Tian
      International Journal of Molecular Sciences.2023; 24(7): 6721.     CrossRef
    • Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice
      Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai
      Food Science and Human Wellness.2023; 12(6): 2211.     CrossRef
    • Fate and distribution of orally-ingested CeO2-nanoparticles based on a mouse model: Implication for human health
      Xingmao Ma, Xiaoxuan Wang, Lei Xu, Honglan Shi, Hu Yang, Kerstin K. Landrock, Virender K. Sharma, Robert S. Chapkin
      Soil & Environmental Health.2023; 1(2): 100017.     CrossRef
    • Lactobacillus paracaseiinfluences the gut-microbiota-targeted metabolic modulation of the immune status of diarrheal mice
      Shunan Ren, Chunjie Wang, Aorigele Chen, Zhaoxing Bai, Yanping Tian, Wenting Lv
      Food & Function.2023; 14(9): 4368.     CrossRef
    • Dietary 5-demethylnobiletin prevents antibiotic-associated dysbiosis of gut microbiota and damage to the colonic barrier
      Minmin Zhan, Xinyan Liang, Jiaqi Chen, Xiaoshuang Yang, Yanhui Han, Chenxi Zhao, Jie Xiao, Yong Cao, Hang Xiao, Mingyue Song
      Food & Function.2023; 14(9): 4414.     CrossRef
    • Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance
      Yingao Qi, Tenghui Zheng, Siwang Yang, Qianzi Zhang, Baofeng Li, Xiangfang Zeng, Yongxing Zhong, Fang Chen, Wutai Guan, Shihai Zhang
      Animal Nutrition.2023; 14: 213.     CrossRef
    • Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway
      Yuan-Feng Zou, Cen-Yu Li, Yu-Ping Fu, Xiao-Ping JiZe, Yu-Zhe Zhao, Xi Peng, Jing-Yi Wang, Zhong-Qiong Yin, Yang-Ping Li, Xu Song, Li-Xia Li, Xing-Hong Zhao, Bin Feng, Chao Huang, Gang Ye, Hua-Qiao Tang, Ji Chen, Rui Li, Xing-Fu Chen, Meng-Liang Tian
      International Journal of Biological Macromolecules.2023; 242: 124689.     CrossRef
    • Integrin β6 deficiency protects mice from experimental colitis and colitis-associated carcinoma by altering macrophage polarization
      Qi Sun, Zhihua Lu, Lei Ma, Dong Xue, Chang Liu, Changchun Ye, Wenbo Huang, Yueyan Dang, Fanni Li
      Frontiers in Oncology.2023;[Epub]     CrossRef
    • Fermented Sargassum fusiforme Mitigates Ulcerative Colitis in Mice by Regulating the Intestinal Barrier, Oxidative Stress, and the NF-κB Pathway
      Siteng Zhang, Yu Cao, Zixuan Wang, Huanhuan Liu, Yue Teng, Guopeng Li, Jiaxiu Liu, Xiaodong Xia
      Foods.2023; 12(10): 1928.     CrossRef
    • Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation
      Yimeng Fan, Qingyu Zhao, Yuanyuan Wei, Huiru Wang, Yu Ga, Yannan Zhang, Zhihui Hao
      Antioxidants.2023; 12(5): 1122.     CrossRef
    • Digested Cinnamon (Cinnamomum verum J. Presl) Bark Extract Modulates Claudin-2 Gene Expression and Protein Levels under TNFα/IL-1β Inflammatory Stimulus
      Elena Lonati, Gessica Sala, Paolo Corbetta, Stefania Pagliari, Emanuela Cazzaniga, Laura Botto, Pierangela Rovellini, Ilaria Bruni, Paola Palestini, Alessandra Bulbarelli
      International Journal of Molecular Sciences.2023; 24(11): 9201.     CrossRef
    • Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays
      Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey, H. Troy Nagle
      Journal of Toxicology and Environmental Health, Part B.2023; 26(6): 307.     CrossRef
    • Bacillus coagulans GBI-30, 6086 (BC30) improves lactose digestion in rats exposed to a high-lactose meal
      Joan Teichenné, Úrsula Catalán, Roger Mariné-Casadó, Cristina Domenech-Coca, Anna Mas-Capdevila, Juan María Alcaide-Hidalgo, Gertruda Chomiciute, Ana Rodríguez-García, Ana Hernández, Vanessa Gutierrez, Francesc Puiggròs, Josep M. Del Bas, Antoni Caimari
      European Journal of Nutrition.2023; 62(6): 2649.     CrossRef
    • Antiviral properties of breast milk: a new area of research
      S. G. Gribakin, S. V. Orlova, I. V. Podoprigora
      Medical alphabet.2023; (8): 64.     CrossRef
    • Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets
      Yuying Wu, Bei Cheng, Longxiang Ji, Xiangyun Lv, Yingying Feng, Liu’an Li, Xin Wu
      Animal Nutrition.2023; 14: 249.     CrossRef
    • Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis
      Yunle Liu, Lin Ye, Huodai Chen, Karl Wah Keung Tsim, Xing Shen, Xiangmei Li, Xueling Li, Hongtao Lei
      Ecotoxicology and Environmental Safety.2023; 262: 115154.     CrossRef
    • The Early Impact of Diets Enriched with Saturated and Unsaturated Fatty Acids on Intestinal Inflammation and Tight Junctions.
      Patrícia Brito Rodrigues, Marcella Neves Dátilo, Marcella Ramos Sant'Ana, Guilherme Augusto da Silva Nogueira, Rodrigo Miguel Marin, Susana Castelo Branco Ramos Nakandakari, Leandro Pereira de Moura, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle
      The Journal of Nutritional Biochemistry.2023; : 109410.     CrossRef
    • Efficacy of pectins with different degrees of methyl-esterification and of blockiness in preventing gut epithelial cell barrier disruption and the impact on sodium–glucose co-transporter expression under low and high glucose conditions
      Xin Tang, Martin Beukema, Michela Ferrari, Marthe T. C. Walvoort, Bart J. de Haan, Paul de Vos
      Food & Function.2023; 14(13): 6226.     CrossRef
    • Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment
      Sang-Hun Choi, Jung-Young Eom, Hyun-Jin Kim, Wonhyo Seo, Hyo-Jung Kwun, Do-Kyun Kim, Jihoon Kim, Young-Eun Cho
      Biomaterials Science.2023; 11(16): 5490.     CrossRef
    • Chronotoxicity of Acrylamide in Mice Fed a High-Fat Diet: The Involvement of Liver CYP2E1 Upregulation and Gut Leakage
      Luanfeng Wang, Yanhong Liu, Huajing Gao, Shuqi Ge, Xinru Yao, Chang Liu, Xintong Tan
      Molecules.2023; 28(13): 5132.     CrossRef
    • Distinct Organotypic Platforms Modulate Rainbow Trout (Oncorhynchus mykiss) Intestinal Cell Differentiation In Vitro
      Nicole Verdile, Federica Camin, Radmila Pavlovic, Rolando Pasquariello, Milda Stuknytė, Ivano De Noni, Tiziana A. L. Brevini, Fulvio Gandolfi
      Cells.2023; 12(14): 1843.     CrossRef
    • Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice
      Shasha Hu, Yueting Kou, Xiaochen Liu, Weifang Rong, Hongxiu Han, Guohua Zhang
      Acta Biochimica et Biophysica Sinica.2023; 55(12): 1874.     CrossRef
    • Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
      You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko
      Experimental & Molecular Medicine.2023; 55(7): 1380.     CrossRef
    • A Supplement with Bromelain, Lentinula edodes, and Quercetin: Antioxidant Capacity and Effects on Morphofunctional and Fecal Parameters (Calprotectin, Cortisol, and Intestinal Fermentation Products) in Kennel Dogs
      David Atuahene, Annalisa Costale, Elisa Martello, Alessandro Mannelli, Elisabetta Radice, Davide Giuseppe Ribaldone, Biagina Chiofalo, Bruno Stefanon, Giorgia Meineri
      Veterinary Sciences.2023; 10(8): 486.     CrossRef
    • Injectable Bioadhesive Hydrogels Scavenging ROS and Restoring Mucosal Barrier for Enhanced Ulcerative Colitis Therapy
      Daming Li, Jiao Li, Tao Chen, Xianyan Qin, Lihua Pan, Xin Lin, Wenlang Liang, Qin Wang
      ACS Applied Materials & Interfaces.2023; 15(32): 38273.     CrossRef
    • Dietary supplementation of microalgae mitigates the negative effects of heat stress in broilers
      Ajay Chaudhary, Pravin Mishra, Sadid Al Amaz, Prem Lal Mahato, Razib Das, Rajesh Jha, Birendra Mishra
      Poultry Science.2023; 102(10): 102958.     CrossRef
    • Allulose enhances epithelial barrier function by tight junction regulation via the TLR4/MyD88/NF-κB immune signaling pathway in an intestinal Caco-2 cell model
      Jihye Baek, Jong-Hwa Kim, YoHan Nam, Go-Eun Kim, Kyungheon Ryu, Soonok Sa, Jung-Sook Han, Wonyong Kim
      Journal of Functional Foods.2023; 108: 105721.     CrossRef
    • Beneficial Effects of Lactobacilli Species on Intestinal Homeostasis in Low-Grade Inflammation and Stress Rodent Models and Their Implication in the Modulation of the Adhesive Junctional Complex
      Célia Chamignon, Geoffroy Mallaret, Julie Rivière, Marthe Vilotte, Sead Chadi, Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc, Frédéric Antonio Carvalho, Marco Pane, Pierre-Yves Mousset, Philippe Langella, Sophie Lafay, Luis G. Bermúdez-Humarán
      Biomolecules.2023; 13(9): 1295.     CrossRef
    • Circadian rhythms in colonic function
      Timothy J. Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer
      Frontiers in Physiology.2023;[Epub]     CrossRef
    • Lactic Acid Bacteria Isolated from Human Breast Milk Improve Colitis Induced by 2,4,6-Trinitrobenzene Sulfonic Acid by Inhibiting NF-κB Signaling in Mice
      Kyung-Joo Kim, Suhyun Kyung, Hui Jin, Minju Im, Jae-won Kim, Hyun Su Kim, Se-Eun Jang
      Journal of Microbiology and Biotechnology.2023; 33(8): 1057.     CrossRef
    • Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice
      Lin Xiao, Weidong Dou, Yajie Wang, Huan Deng, Hao Xu, YiSheng Pan
      Biochemical Pharmacology.2023; 216: 115752.     CrossRef
    • Probiotic Properties and Safety Evaluation of Lactobacillus plantarum HY7718 with Superior Storage Stability Isolated from Fermented Squid
      Hyeonji Kim, Myeong-Seok Yoo, Hyejin Jeon, Jae-Jung Shim, Woo-Jung Park, Joo-Yun Kim, Jung-Lyoul Lee
      Microorganisms.2023; 11(9): 2254.     CrossRef
    • The Intertwining Roads between Psychological Distress and Gut Microbiota in Inflammatory Bowel Disease
      Georgiana-Emmanuela Gîlcă-Blanariu, Cristina Gabriela Șchiopu, Gabriela Ștefănescu, Cătălina Mihai, Smaranda Diaconescu, Vlad Adrian Afrăsânie, Vasile Valeriu Lupu, Ancuța Lupu, Alexandra Boloș, Cristinel Ștefănescu
      Microorganisms.2023; 11(9): 2268.     CrossRef
    • Dark Chocolate Intake Positively Modulates Gut Permeability in Elite Football Athletes: A Randomized Controlled Study
      Cristina Nocella, Elena Cavarretta, Chiara Fossati, Fabio Pigozzi, Federico Quaranta, Mariangela Peruzzi, Fabrizio De Grandis, Vincenzo Costa, Carwyn Sharp, Massimo Manara, Antonia Nigro, Vittoria Cammisotto, Valentina Castellani, Vittorio Picchio, Sebast
      Nutrients.2023; 15(19): 4203.     CrossRef
    • Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
      Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià
      Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
    • Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells
      Masoumeh Sadat Mousavi Maleki, Hooman Aghamirza Moghim Ali Abadi, Behrooz Vaziri, Ali Akbar Shabani, Ghazaleh Ghavami, Hamid Madanchi, Soroush Sardari
      Amino Acids.2023; 55(11): 1601.     CrossRef
    • Lactobacillus plantarum ZJUIDS04 alleviates DSS-induced colitis via modulating gut microbiota
      Chongwei Yu, Jingtianyi Liu, Zonghao Liu, Qinchao Ding, Qinchao Zhu, Nan Chen, Jinfeng Fu, Teresa G. Valencak, Daxi Ren
      Journal of Functional Foods.2023; 109: 105794.     CrossRef
    • Profiling of the fecal microbiota and circulating microRNA-16 in IBS subjects with Blastocystis infection : a case–control study
      Alireza Olyaiee, Abbas Yadegar, Elnaz Sadat Mirsamadi, Amir Sadeghi, Hamed Mirjalali
      European Journal of Medical Research.2023;[Epub]     CrossRef
    • Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice
      Ting Zheng, Haining Hao, Qiqi Liu, Jiankun Li, Yukun Yao, Yisuo Liu, Tai Zhang, Zhe Zhang, Huaxi Yi
      Nutrients.2023; 15(22): 4722.     CrossRef
    • Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status
      Karen Knipping, Shirley W. Kartaram, Marc Teunis, Nicolaas P. A. Zuithoff, Nicole Buurman, Laura M’Rabet, Klaske van Norren, Renger Witkamp, Raymond Pieters, Johan Garssen, David M. Ojcius
      PLOS ONE.2023; 18(11): e0291297.     CrossRef
    • Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism
      Zhong-Hao Ji, Song He, Wen-Yin Xie, Pei-Sen Zhao, Wen-Zhi Ren, Wei Gao, Bao Yuan
      Nutrients.2023; 15(23): 4877.     CrossRef
    • The Contribution of the Intestinal Microbiota to the Celiac Disease Pathogenesis along with the Effectiveness of Probiotic Therapy
      Oxana Zolnikova, Natiya Dzhakhaya, Elena Bueverova, Alla Sedova, Anastasia Kurbatova, Kira Kryuchkova, Tatyana Butkova, Alexander Izotov, Ludmila Kulikova, Kseniya Yurku, Pavel Chekulaev, Victoria Zaborova
      Microorganisms.2023; 11(12): 2848.     CrossRef
    • Potential Toxicity and Mechanisms of T-2 and HT-2 Individually or in Combination on the Intestinal Barrier Function of Porcine Small Intestinal Epithelial Cells
      Weihua He, Jianhua Wang, Mengyi Han, Lihua Wang, Ling Li, Jiahui Zhang, Siqi Chen, Jiayi Guo, Xiaohu Zhai, Junhua Yang
      Toxins.2023; 15(12): 682.     CrossRef
    • Protective effects of different Bacteroides vulgatus strains against lipopolysaccharide-induced acute intestinal injury, and their underlying functional genes
      Chen Wang, Yue Xiao, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
      Journal of Advanced Research.2022; 36: 27.     CrossRef
    • Homeostasis effects of fermented Maillard reaction products by Lactobacillus gasseri 4M13 in dextran sulfate sodium‐induced colitis mice
      Yu‐Jin Jeong, Da Hyun Kim, Kwang‐Won Lee
      Journal of the Science of Food and Agriculture.2022; 102(1): 434.     CrossRef
    • Enterococcus faecium HDRsEf1 inhibits Lipopolysaccharide‐induced downregulation of zona occludens ‐1 expression via toll‐like receptor 2/4‐mediated c‐Jun N‐terminal kinase/activator protein‐1 signalling pathways
      L. Liu, Y. Li, Y. He, Z. Wang, H. Zhao, X. Jin, D. Shi, X. Wang
      Journal of Applied Microbiology.2022; 132(1): 605.     CrossRef
    • Protection against indomethacin-induced loss of intestinal epithelial barrier function by a quercetin oxidation metabolite present in onion peel: In vitro and in vivo studies
      Jocelyn Fuentes, Oscar Brunser, Elías Atala, José Herranz, Adriano Costa de Camargo, Hermann Zbinden-Foncea, Hernán Speisky
      The Journal of Nutritional Biochemistry.2022; 100: 108886.     CrossRef
    • Effect of blending encapsulated essential oils and organic acids as an antibiotic growth promoter alternative on growth performance and intestinal health in broilers with necrotic enteritis
      Van Hieu Pham, Waseem Abbas, Jinyu Huang, Qiang He, Wenrui Zhen, Yuming Guo, Zhong Wang
      Poultry Science.2022; 101(1): 101563.     CrossRef
    • Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System
      Niranjan G. Kotla, Isma Liza Mohd Isa, Swetha Rasala, Secil Demir, Rajbir Singh, Becca V. Baby, Samantha K. Swamy, Peter Dockery, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
      Advanced Science.2022;[Epub]     CrossRef
    • Post-Cardiac Arrest Syndrome Is Not Associated With an Early Bacterial Translocation
      Eirini Filidou, Gesthimani Tarapatzi, Michail Spathakis, Panagiotis Papadopoulos, Charalampos Papadopoulos, Leonidas Kandilogiannakis, George Stavrou, Eleni Doumaki, Antonia Sioga, Soultana Meditskou, Konstantinos Arvanitidis, Theodora Papamitsou, Vassili
      Journal of Surgical Research.2022; 272: 51.     CrossRef
    • Re-aliment regains feed deprivation-induced microflora dysbiosis and immune stress in the gut of red swamp crayfish (Procambarus clarkii)
      Minglang Cai, Honghui Li, Xizhang Gu, Hongyan Tian, Fei Liu, Wenping Yang, Shengjie Ren, Wuying Chu, Yi Hu, Aimin Wang, Hongqin Li, Jiajia Li
      Aquaculture Reports.2022; 22: 100992.     CrossRef
    • Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship
      Małgorzata Gieryńska, Lidia Szulc-Dąbrowska, Justyna Struzik, Matylda Barbara Mielcarska, Karolina Paulina Gregorczyk-Zboroch
      Animals.2022; 12(2): 145.     CrossRef
    • Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity
      Kwangwook Kim, Yijie He, Cynthia Jinno, Lauren Kovanda, Xunde Li, David Bravo, Eric Cox, Yanhong Liu
      Journal of Animal Science and Biotechnology.2022;[Epub]     CrossRef
    • Salvia miltiorrhiza Bge. (Danshen) for Inflammatory Bowel Disease: Clinical Evidence and Network Pharmacology-Based Strategy for Developing Supplementary Medical Application
      Siyuan Zhang, Hua Luo, Shiyi Sun, Yating Zhang, Jiaqi Ma, Yuting Lin, Lin Yang, Dechao Tan, Chaomei Fu, Zhangfeng Zhong, Yitao Wang
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • The Intestinal Effect of Atorvastatin: Akkermansia muciniphila and Barrier Function
      Tingting Cheng, Changkun Li, Linyan Shen, Shujie Wang, Xuelin Li, Chenyang Fu, Tingting Li, Bei Liu, Yanyun Gu, Weiqing Wang, Bo Feng
      Frontiers in Microbiology.2022;[Epub]     CrossRef
    • Resveratrol alleviates aluminum‐induced intestinal barrier dysfunction in mice
      Wudi Hao, Xiaoying Zhu, Ziyue Liu, Yushuai Song, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
      Environmental Toxicology.2022; 37(6): 1373.     CrossRef
    • Effects of encapsulated butyrate and salinomycin on gut leakage and intestinal inflammation in broilers
      M. Naghizadeh, T. S. Dalgaard, L. Klaver, R. M. Engberg
      British Poultry Science.2022; 63(4): 499.     CrossRef
    • Epigenetic modification in alcohol‐related liver diseases
      Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
      Medicinal Research Reviews.2022; 42(4): 1463.     CrossRef
    • Intestinal barrier disorders and metabolic endotoxemia in obesity: Current knowledge
      Marta Potrykus, Michał Szymański, Łukasz Kaska, Agata Janczy
      Postępy Higieny i Medycyny Doświadczalnej.2022; 76(1): 71.     CrossRef
    • Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier
      Youxia Wang, Changming Hong, Zebiao Wu, Shuwei Li, Yaoyao Xia, Yuying Liang, Xiaohua He, Xinyu Xiao, Wenjie Tang
      Frontiers in Nutrition.2022;[Epub]     CrossRef
    • Effects of Caulis Spatholobi Polysaccharide on Immunity, Intestinal Mucosal Barrier Function, and Intestinal Microbiota in Cyclophosphamide-Induced Immunosuppressive Chickens
      Yao Cui, Wenjing Sun, Qinmei Li, Kaijun Wang, Yuhan Wang, Feifei Lv, Xiaogang Chen, Xiaomin Peng, Ying Wang, Jiang Li, Hongbin Si
      Frontiers in Veterinary Science.2022;[Epub]     CrossRef
    • An in vitro intestinal model captures immunomodulatory properties of the microbiota in inflammation
      Jaclyn Y. Lock, Mariaelena Caboni, Philip Strandwitz, Madeleine Morrissette, Kevin DiBona, Brian A. Joughin, Kim Lewis, Rebecca L. Carrier
      Gut Microbes.2022;[Epub]     CrossRef
    • The roles of catechins in regulation of systemic inflammation
      Jong Min Kim, Ho Jin Heo
      Food Science and Biotechnology.2022; 31(8): 957.     CrossRef
    • The GLIM Criteria Represent a More Appropriate Tool for Nutritional Assessment in Patients With Crohn's Disease
      Yong Li, Ziheng Peng, Duo Xu, Yu Peng, Xiaowei Liu
      Frontiers in Nutrition.2022;[Epub]     CrossRef
    • Lactobacillus paracasei from koumiss ameliorates diarrhea in mice via tight junctions modulation
      Shunan Ren, Aorigele Chen, Yanping Tian, Zhaoxing Bai, Chunjie Wang
      Nutrition.2022; 98: 111584.     CrossRef
    • Microbial Imbalance Induces Inflammation by Promoting Salmonella Penetration through the Mucosal Barrier
      Abhinav Sharma, Vishnu Raman, Jungwoo Lee, Neil S. Forbes
      ACS Infectious Diseases.2022; 8(5): 969.     CrossRef
    • Microscopic Visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale
      Bieke Vanslembrouck, Jian-hua Chen, Carolyn Larabell, Jolanda van Hengel
      Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
    • Modulation of microRNAs and claudin-7 in Caco-2 cell line treated with Blastocystis sp., subtype 3 soluble total antigen
      Hanieh Mohammad Rahimi, Abbas Yadegar, Hamid Asadzadeh Aghdaei, Hamed Mirjalali, Mohammad Reza Zali
      BMC Microbiology.2022;[Epub]     CrossRef
    • Stachyose protects intestinal mucosal barrier via promotion of tight junction and Lactobacillus casei-drived inhibition of apoptosis in juvenile turbot, Scophthalmus maximus L.
      Jihong Dai, Yanjiao Zhang, Weihao Ou, Guijuan Yu, Qinghui Ai, Wenbing Zhang, Kangsen Mai
      Aquaculture.2022; 556: 738280.     CrossRef
    • Intestinal Barrier Permeability in Allergic Diseases
      Monika Niewiem, Urszula Grzybowska-Chlebowczyk
      Nutrients.2022; 14(9): 1893.     CrossRef
    • The Effect of Probiotics on Intestinal Tight Junction Protein Expression in Animal  Models: A Meta-Analysis
      Sung-Il Ahn, Sangbuem Cho, Eunjeong Jeon, Myungsun Park, Byungho Chae, Isaac Celestin Poaty Ditengou, Nag-Jin Choi
      Applied Sciences.2022; 12(9): 4680.     CrossRef
    • Modulating effects of a functional food containing Dendrobium officinale on immune response and gut microbiota in mice treated with cyclophosphamide
      Ying-Jie Dong, Min-Qiu Lin, Xi Fang, Zhi-Yi Xie, Rong Luo, Xi Teng, Bin Li, Bo Li, Lin-Zi Li, Hai-Ying Jin, Qiao-Xian Yu, Gui-Yuan Lv, Su-Hong Chen
      Journal of Functional Foods.2022; 94: 105102.     CrossRef
    • L-glutamine for sickle cell disease: more than reducing redox
      Firas Jafri, Gyuhee Seong, Tim Jang, Emanuela Cimpeanu, Maria Poplawska, Dibyendu Dutta, Seah H. Lim
      Annals of Hematology.2022; 101(8): 1645.     CrossRef
    • The Increase of miR-195-5p Reduces Intestinal Permeability in Ulcerative Colitis, Modulating Tight Junctions’ Expression
      Viviana Scalavino, Emanuele Piccinno, Giusy Bianco, Nicolò Schena, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino
      International Journal of Molecular Sciences.2022; 23(10): 5840.     CrossRef
    • Ischemic stroke and intestinal flora: an insight into brain–gut axis
      Wenjie Hu, Xiangyi Kong, Hui Wang, Yunqing Li, Yimin Luo
      European Journal of Medical Research.2022;[Epub]     CrossRef
    • Protective Effects of Oxyberberine in 5-Fluorouracil-Induced Intestinal Mucositis in the Mice Model
      Ronglei Huang, Gaoxiang Ai, Linjiang Zhong, Liting Mai, Jian-Nan Chen, Yuhong Liu, Yucui Li, Xiaoqi Huang, Ziren Su, Janis Ya-Xian Zhan, Zewei Sun
      Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
    • Effects of Tannic Acid Supplementation on Growth Performance, Oocyst Shedding, and Gut Health of in Broilers Infected with Eimeria Maxima
      Janghan Choi, Yuguo Tompkins, Po-Yun Teng, Robert Gogal, Woo Kim
      Animals.2022; 12(11): 1378.     CrossRef
    • Incorporation of Fructooligosaccharides in Diets Influence Growth Performance, Digestive Enzyme Activity, and Expression of Intestinal Barrier Function Genes in Tropical Gar (Atractosteus tropicus) Larvae
      Graciela M. Pérez-Jiménez, Emyr Saul Peña-Marín, Claudia I. Maytorena-Verdugo, Cesar Antonio Sepúlveda-Quiroz, Luis Daniel Jiménez-Martínez, Susana De la Rosa-García, Gloria Gertrudys Asencio-Alcudia, Rafael Martínez, Dariel Tovar-Ramírez, Mario A. Galavi
      Fishes.2022; 7(3): 137.     CrossRef
    • Comparison of Selenium-Enriched Lactobacillusparacasei, Selenium-Enriched Yeast, and Selenite for the Alleviation of DSS-Induced Colitis in Mice
      Yuqing Zhong, Yan Jin, Qiuxiang Zhang, Bingyong Mao, Xin Tang, Jie Huang, Renmei Guo, Jianxin Zhao, Shumao Cui, Wei Chen
      Nutrients.2022; 14(12): 2433.     CrossRef
    • Lactobacillus acidophilus Supplementation Restores Gut Epithelial Integrities and Barrier Functions in Non-specific Diarrhea
      Hossain Ferdaus Mohd ALTAF, Sumaiya Islam FARZANA, Khan PARVEZ, Zahran EMAN, Atif Shaikh MUHAMMAD, Uddin Md NAZIM, Zinnah Kazi Mohammad ALİ, Khan IMDAD ULLAH, Rahman Md MASUDUR
      Journal of Microbiology and Infectious Diseases.2022; : 54.     CrossRef
    • Mechanisms of proton pump inhibitor‐induced hypomagnesemia
      Lisanne M. M. Gommers, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
      Acta Physiologica.2022;[Epub]     CrossRef
    • Manipulation of Gut Microbiota as a Key Target for Crohn's Disease
      Reem Rashed, Rosica Valcheva, Levinus A. Dieleman
      Frontiers in Medicine.2022;[Epub]     CrossRef
    • Inflammatory bowel disease: an overview of Chinese herbal medicine formula-based treatment
      Shuo Yuan, Qi Wang, Jiao Li, Jia-Chen Xue, You Li, Huan Meng, Xiao-Ting Hou, Ji-Xing Nan, Qing-Gao Zhang
      Chinese Medicine.2022;[Epub]     CrossRef
    • Gut Microbiota-Derived Indole-3-Carboxylate Influences Mucosal Integrity and Immunity Through the Activation of the Aryl Hydrocarbon Receptors and Nutrient Transporters in Broiler Chickens Challenged With Eimeria maxima
      Inkyung Park, Hyoyoun Nam, Doyun Goo, Samiru S. Wickramasuriya, Noah Zimmerman, Alexandra H. Smith, Thomas G. Rehberger, Hyun S. Lillehoj
      Frontiers in Immunology.2022;[Epub]     CrossRef
    • Lactobacillus casei-fermented blueberry pomace ameliorates colonic barrier function in high fat diet mice through MAPK-NF-κB-MLCK signaling pathway
      Yuxin Cheng, Shuxin Tang, Ting Wu, Siyi Pan, Xiaoyun Xu
      Journal of Functional Foods.2022; 95: 105139.     CrossRef
    • Gut microbiome and autoimmune disorders
      Walaa Abdelaty Shaheen, Mohammed Nabil Quraishi, Tariq H Iqbal
      Clinical and Experimental Immunology.2022; 209(2): 161.     CrossRef
    • Role of ErbB1 in the Underlying Mechanism of Lapatinib-Induced Diarrhoea: A Review
      Raja Nur Firzanah Syaza Raja Sharin, Jesmine Khan, Mohamad Johari Ibahim, Mudiana Muhamad, Joanne Bowen, Wan Nor I’zzah Wan Mohamad Zain, Supat Chupradit
      BioMed Research International.2022; 2022: 1.     CrossRef
    • Colonic Microflora Protagonist of Liver Metabolism and Gut Permeability: Study on Mice Model
      Sweta Patel, Dipeeka Mandaliya, Sriram Seshadri
      Indian Journal of Microbiology.2022; 62(4): 540.     CrossRef
    • Role of CB1 receptors in the acute regulation of small intestinal permeability: effects of high-fat diet
      Hailey Cuddihey, Jean-Baptiste Cavin, Catherine M. Keenan, Laurie E. Wallace, Kiran Vemuri, Alexandros Makriyannis, Wallace K. MacNaughton, Keith A. Sharkey
      American Journal of Physiology-Gastrointestinal and Liver Physiology.2022; 323(3): G219.     CrossRef
    • Roasted garlic protects against leaky gut syndrome in dextran sodium sulfate-induced colitis mice
      Divya Sharma, Madhuri Sangar, Jeom-Leon Park, Seong-Gook Kang, Kyung-Sik Ham
      Food Science and Biotechnology.2022; 31(10): 1335.     CrossRef
    • Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
      Hailey Cuddihey, Wallace K. MacNaughton, Keith A. Sharkey
      Cellular and Molecular Gastroenterology and Hepatology.2022; 14(4): 947.     CrossRef
    • Ameliorating Effects of TRIM67 against Intestinal Inflammation and Barrier Dysfunction Induced by High Fat Diet in Obese Mice
      Qihui Luo, Asad Jahangir, Junbo He, Chao Huang, Yu Xia, Lanlan Jia, Xiaoli Wei, Ting Pan, Yanni Du, Bin Mu, Huan Gong, Wentao Liu, Saif Ur-Rehman, Kangcheng Pan, Zhengli Chen
      International Journal of Molecular Sciences.2022; 23(14): 7650.     CrossRef
    • Multiorgan‐on‐a‐chip for realization of gut‐skin axis
      Hye Ri Lee, Jong Hwan Sung
      Biotechnology and Bioengineering.2022; 119(9): 2590.     CrossRef
    • Sanhuang Xiexin decoction ameliorates DSS-induced colitis in mice by regulating intestinal inflammation, intestinal barrier, and intestinal flora
      Xueyuan Wu, Shu Fu, Miao Jiang, Jing Wang, Huaqiao Tang, Chunlin Fang, Wen Li, Chaomei Fu
      Journal of Ethnopharmacology.2022; 297: 115537.     CrossRef
    • Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease
      De-feng Li, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Jian-yao Wang, Yu-jie Liang, Jun Yao, Li-sheng Wang
      Journal of Materials Chemistry B.2022; 10(31): 5853.     CrossRef
    • Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions
      Fahimeh Zamani Rarani, Mohammad Zamani Rarani, Michael R. Hamblin, Bahman Rashidi, Seyed Mohammad Reza Hashemian, Hamed Mirzaei
      Cellular & Molecular Biology Letters.2022;[Epub]     CrossRef
    • Intestinal Osteopontin Protects From Alcohol-induced Liver Injury by Preserving the Gut Microbiome and the Intestinal Barrier Function
      Sukanta Das, Zhuolun Song, Hui Han, Xiaodong Ge, Romain Desert, Dipti Athavale, Sai Santosh Babu Komakula, Fernando Magdaleno, Wei Chen, Daniel Lantvit, Grace Guzman, Natalia Nieto
      Cellular and Molecular Gastroenterology and Hepatology.2022; 14(4): 813.     CrossRef
    • Pterostilbene attenuates intestinal epithelial barrier loss induced by high loading intensity of exercise
      Lidong Zhang, Guoliang Tian, Li Huang, Min Zhou, Jundong Zhu, Long Yi, Mantian Mi
      Frontiers in Nutrition.2022;[Epub]     CrossRef
    • Stem Cell-Based Therapies for Inflammatory Bowel Disease
      Hua-Min Zhang, Shuo Yuan, Huan Meng, Xiao-Ting Hou, Jiao Li, Jia-Chen Xue, You Li, Qi Wang, Ji-Xing Nan, Xue-Jun Jin, Qing-Gao Zhang
      International Journal of Molecular Sciences.2022; 23(15): 8494.     CrossRef
    • Sex-dependent Lupus Blautia (Ruminococcus) gnavus strain induction of zonulin-mediated intestinal permeability and autoimmunity
      Gregg J. Silverman, Jing Deng, Doua F. Azzouz
      Frontiers in Immunology.2022;[Epub]     CrossRef
    • Mannose ameliorates experimental colitis by protecting intestinal barrier integrity
      Lijun Dong, Jingwen Xie, Youyi Wang, Honglian Jiang, Kai Chen, Dantong Li, Jing Wang, Yunzhi Liu, Jia He, Jia Zhou, Liyun Zhang, Xiao Lu, Xiaoming Zou, Xiang-Yang Wang, Qingqing Wang, Zhengliang Chen, Daming Zuo
      Nature Communications.2022;[Epub]     CrossRef
    • Comparison of the Modulating Effect of Anthocyanin-Rich Sour Cherry Extract on Occludin and ZO-1 on Caco-2 and HUVEC Cultures
      Judit Remenyik, Attila Biró, Ágnes Klusóczki, Krisztián Zoltán Juhász, Tímea Szendi-Szatmári, Ádám Kenesei, Erzsébet Szőllősi, Gábor Vasvári, László Stündl, Ferenc Fenyvesi, Judit Váradi, Arnold Markovics
      International Journal of Molecular Sciences.2022; 23(16): 9036.     CrossRef
    • Regulatory Effect of Isomaltodextrin on a High-Fat Diet Mouse Model with LPS-Induced Low-Grade Chronic Inflammation
      Yijun Liu, Yuhan Zeng, Yixin Liu, Xiaoya Wang, Yuhuan Chen, Dion Lepp, Rong Tsao, Tsuyoshi Sadakiyo, Hua Zhang, Yoshinori Mine
      Journal of Agricultural and Food Chemistry.2022; 70(36): 11258.     CrossRef
    • Hemp-Derived Nanovesicles Protect Leaky Gut and Liver Injury in Dextran Sodium Sulfate-Induced Colitis
      Jung-Young Eom, Sang-Hun Choi, Hyun-Jin Kim, Dong-ha Kim, Ju-Hyun Bae, Gi-Seok Kwon, Dong-hee Lee, Jin-Hyeon Hwang, Do-Kyun Kim, Moon-Chang Baek, Young-Eun Cho
      International Journal of Molecular Sciences.2022; 23(17): 9955.     CrossRef
    • Bifidobacterium breve Alleviates DSS-Induced Colitis in Mice by Maintaining the Mucosal and Epithelial Barriers and Modulating Gut Microbes
      Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Xiang-Chen Meng
      Nutrients.2022; 14(18): 3671.     CrossRef
    • High Molecular Weight Fucoidan Restores Intestinal Integrity by Regulating Inflammation and Tight Junction Loss Induced by Methylglyoxal-Derived Hydroimidazolone-1
      Jae-Min Lim, Hee Joon Yoo, Kwang-Won Lee
      Marine Drugs.2022; 20(9): 580.     CrossRef
    • Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease
      Shuo Yuan, You Li, Jiao Li, Jia-Chen Xue, Qi Wang, Xiao-Ting Hou, Huan Meng, Ji-Xing Nan, Qing-Gao Zhang
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption
      Zhi-Feng Jiang, Wei Wu, Han-Bing Hu, Zheng-Yang Li, Ming Zhong, Lin Zhang
      World Journal of Gastroenterology.2022; 28(36): 5265.     CrossRef
    • Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice
      Kaidong Wang, Chunhui Zhang, Baofu Zhang, Guoliang Li, Ge Shi, Qian Cai, Min Huang
      Ecotoxicology and Environmental Safety.2022; 246: 114152.     CrossRef
    • Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7
      Ying Xiao, Haifeng Lian, Xiaoying S. Zhong, Srikruthi S. Krishnachaitanya, Yingzi Cong, Roderick H. Dashwood, Tor C. Savidge, Don W. Powell, Xiaowei Liu, Qingjie Li
      Frontiers in Immunology.2022;[Epub]     CrossRef
    • Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens
      Yujing Shao, Wenrui Zhen, Fangshen Guo, Zeqiong Hu, Kaichen Zhang, Linhua Kong, Yuming Guo, Zhong Wang
      Journal of Animal Science and Biotechnology.2022;[Epub]     CrossRef
    • Interaction and toxicity of ingested nanoparticles on the intestinal barrier
      Thomas Stalder, Taghrid Zaiter, Wassim El-Basset, Raphaël Cornu, Hélène Martin, Mona Diab-Assaf, Arnaud Béduneau
      Toxicology.2022; 481: 153353.     CrossRef
    • Investigation of murine host sex as a biological variable in epithelial barrier function and muscle contractility in human intestinal organoids
      Brooke T. Beanland, Eoin P. McNeill, David J. Sequeira, Hasen Xue, Noah F. Shroyer, Allison L. Speer
      The FASEB Journal.2022;[Epub]     CrossRef
    • Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFκB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats
      Yi Ma, Mawda Elmhadi, Chao Wang, Zelin Li, Hao Zhang, Banglin He, Xiujuan Zhao, Zhenbin Zhang, Hongrong Wang
      Antioxidants.2022; 11(10): 2048.     CrossRef
    • Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options
      Zahid Hussain, Hyojin Park
      Journal of Neurogastroenterology and Motility.2022; 28(4): 517.     CrossRef
    • Senegalia macrostachya seed polysaccharides attenuate inflammation-induced intestinal epithelial barrier dysfunction in a Caco-2 and RAW264.7 macrophage co-culture model by inhibiting the NF-κB/MLCK pathway
      Abel Wend-Soo Zongo, Daniel Zogona, Mahmoud Youssef, Shuxin Ye, Fuchao Zhan, Jing Li, Bin Li
      Food & Function.2022; 13(22): 11676.     CrossRef
    • Zearalenone-Induced Mechanical Damage of Intestinal Barrier via the RhoA/ROCK Signaling Pathway in IPEC-J2 Cells
      Biying Huang, Jingjing Wang, Aixin Gu, Tianhu Wang, Jianping Li, Anshan Shan
      International Journal of Molecular Sciences.2022; 23(20): 12550.     CrossRef
    • A Review of the Chemistry and Biological Activities of Acmella oleracea (“jambù”, Asteraceae), with a View to the Development of Bioinsecticides and Acaricides
      Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Loredana Cappellacci, Margherita Marmugi, Alice Caselli, Giovanni Benelli, Filippo Maggi, Riccardo Petrelli
      Plants.2022; 11(20): 2721.     CrossRef
    • The Importance of Nutritional Aspects in the Assessment of Inflammation and Intestinal Barrier in Patients with Inflammatory Bowel Disease
      Olga Kaczmarczyk, Agnieszka Dąbek-Drobny, Agnieszka Piątek-Guziewicz, Michał Woźniakiewicz, Paweł Paśko, Justyna Dobrowolska-Iwanek, Aneta Woźniakiewicz, Aneta Targosz, Agata Ptak-Belowska, Urszula Szczyrk, Małgorzata Strzałka, Paweł Zagrodzki, Małgorzata
      Nutrients.2022; 14(21): 4622.     CrossRef
    • Insight into role of short chain fatty acids in regulating intestinal mucosal barrier and alleviating inflammatory bowel disease
      Xue-Ran Guo, Cheng-Wei He, Han Gao, Rong-Xuan Hua, Chen Liang, Yi-Xuan Du, Hong-Wei Shang, Xin Lu, Jing-Dong Xu
      World Chinese Journal of Digestology.2022; 30(21): 928.     CrossRef
    • Metabolites of Latilactobacillus curvatus BYB3 and Indole Activate Aryl Hydrocarbon Receptor to Attenuate Lipopolysaccharide-Induced Intestinal Barrier Dysfunction
      Xing Wang, Cheng Chung Yong, Sejong Oh
      Food Science of Animal Resources.2022; 42(6): 1046.     CrossRef
    • Microbiota Dysbiosis and Gut Barrier Dysfunction Associated with Non-Alcoholic Fatty Liver Disease Are Modulated by a Specific Metabolic Cofactors’ Combination
      Sergio Quesada-Vázquez, Caitlin Bone, Shikha Saha, Iris Triguero, Marina Colom-Pellicer, Gerard Aragonès, Falk Hildebrand, Josep M. del Bas, Antoni Caimari, Naiara Beraza, Xavier Escoté
      International Journal of Molecular Sciences.2022; 23(22): 13675.     CrossRef
    • Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice
      Yingying Miao, Qin Zhang, Zihang Yuan, Jie Wang, Yunxia Xu, Yuanyuan Chai, Min Du, Qinwei Yu, Luyong Zhang, Zhenzhou Jiang
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • The Effects of Dietary Bacillus amyloliquefaciens TL106 Supplementation, as an Alternative to Antibiotics, on Growth Performance, Intestinal Immunity, Epithelial Barrier Integrity, and Intestinal Microbiota in Broilers
      Chengling Bao, Wenxiu Zhang, Jian Wang, Yajing Liu, Heng Cao, Feiyu Li, Suozhu Liu, Zhengda Shang, Yunhe Cao, Bing Dong
      Animals.2022; 12(22): 3085.     CrossRef
    • Effect of dietary oregano oil on growth performance, disease resistance, intestinal morphology, immunity, and microbiota of hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)
      Yu Xin, Hao Liu, Xiaobo Yan, Weibin Huang, Simiao Pan, Menglong Zhou, Baiquan Lu, Beiping Tan, Xiaohui Dong, Yuanzhi Yang
      Frontiers in Marine Science.2022;[Epub]     CrossRef
    • Comparison between Lactobacillus rhamnosus GG and LuxS-deficient strain in regulating gut barrier function and inflammation in early-weaned piglets
      Zhaoxi Deng, Jinyan Dai, Yusen Wei, Yanfei Ma, Yingying Mao, Jinzhi Zhang, Weidong Hua, Haifeng Wang
      Frontiers in Immunology.2022;[Epub]     CrossRef
    • Influence of Effective Microorganisms and Clinoptilolite on Gut Barrier Function, Intestinal Health and Performance of Broiler Chickens during Induced Eimeria tenella Infection
      Artur Ciszewski, Łukasz S. Jarosz, Marcin Kalinowski, Agnieszka Marek, Zbigniew Grądzki, Sebastian Grabowski, Marcin Hejdysz, Sebastian Nowaczewski, Anna Rysiak
      Agriculture.2022; 12(12): 2176.     CrossRef
    • A food pyramid, based on a review of the emerging literature, for subjects with inflammatory bowel disease
      Mariangela Rondanelli, Silvia Lamburghini, Milena A. Faliva, Gabriella Peroni, Antonella Riva, Pietro Allegrini, Daniele Spadaccini, Clara Gasparri, Giancarlo Iannello, Vittoria Infantino, Tariq A. Alalwan, Simone Perna, Alessandra Miccono
      Endocrinología, Diabetes y Nutrición.2021; 68(1): 17.     CrossRef
    • LncRNA: A Potential Research Direction in Intestinal Barrier Function
      Zhi-Feng Jiang, Lin Zhang
      Digestive Diseases and Sciences.2021; 66(5): 1400.     CrossRef
    • Site‐specific contribution of Toll‐like receptor 4 to intestinal homeostasis and inflammatory disease
      Elise E. Bruning, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
      Journal of Cellular Physiology.2021; 236(2): 877.     CrossRef
    • Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders
      Charlotte A. Alemao, Kurtis F. Budden, Henry M. Gomez, Saima F. Rehman, Jacqueline E. Marshall, Shakti D. Shukla, Chantal Donovan, Samuel C. Forster, Ian A. Yang, Simon Keely, Elizabeth R. Mann, Emad M. El Omar, Gabrielle T. Belz, Philip M. Hansbro
      Allergy.2021; 76(3): 714.     CrossRef
    • One‐Pot Synthesis of pH‐Responsive Eudragit‐Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease
      Zhi Qu, Kuan Yau Wong, Md. Moniruzzaman, Jakob Begun, Hélder A Santos, Sumaira Z. Hasnain, Tushar Kumeria, Michael A. McGuckin, Amirali Popat
      Advanced Therapeutics.2021;[Epub]     CrossRef
    • In Vivo Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression
      Mariaelena A. Boyle, David J. Sequeira, Eoin P. McNeill, Zachary K. Criss, Noah F. Shroyer, Allison L. Speer
      Journal of Surgical Research.2021; 259: 500.     CrossRef
    • Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1
      Xin Zong, Xiao Xiao, Lixia Kai, Yuanzhi Cheng, Jie Fu, Wei Xu, Yizhen Wang, Ke Zhao, Mingliang Jin
      International Journal of Biological Macromolecules.2021; 167: 76.     CrossRef
    • Dose-dependent effects of lead induced gut injuries: An in vitro and in vivo study
      Leilei Yu, Yaqi Yu, Ruijie Yin, Hui Duan, Dingwu Qu, Fengwei Tian, Arjan Narbad, Wei Chen, Qixiao Zhai
      Chemosphere.2021; 266: 129130.     CrossRef
    • A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity
      Anoop Kumar, Shubha Priyamvada, Yong Ge, Dulari Jayawardena, Megha Singhal, Arivarasu N. Anbazhagan, Ishita Chatterjee, Aneal Dayal, Mitul Patel, Kimia Zadeh, Seema Saksena, Waddah A. Alrefai, Ravinder K. Gill, Mojgan Zadeh, Ni Zhao, Mansour Mohamadzadeh,
      Gastroenterology.2021; 160(4): 1240.     CrossRef
    • Vancomycin-Induced Changes in Host Immunity and Behavior: Comparative Genomic and Metagenomic Analysis in C57BL/6 and BALB/c Mice
      Pratikshya Ray, Uday Pandey, Debasmita Das, Palok Aich
      Digestive Diseases and Sciences.2021; 66(11): 3776.     CrossRef
    • Thermal or membrane processing for Infant Milk Formula: Effects on protein digestion and integrity of the intestinal barrier
      Simona L. Bavaro, Gianfranco Mamone, Gianluca Picariello, Michael J. Callanan, Yihong Chen, André Brodkorb, Linda Giblin
      Food Chemistry.2021; 347: 129019.     CrossRef
    • Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis
      Shara Francesca Rapa, Rosanna Di Paola, Marika Cordaro, Rosalba Siracusa, Ramona D’Amico, Roberta Fusco, Giuseppina Autore, Salvatore Cuzzocrea, Hermann Stuppner, Stefania Marzocco
      Biomedicines.2021; 9(1): 67.     CrossRef
    • Intestinal changes associated with fluoride exposure in rats: Integrative morphological, proteomic and microbiome analyses
      Aline Dionizio, Dawud Abduweli Uyghurturk, Carina Guimarães Souza Melo, Isabela Tomazini Sabino-Arias, Tamara Teodoro Araujo, Talita Mendes Silva Ventura, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni, Pamela Den Besten, Marília Afonso
      Chemosphere.2021; 273: 129607.     CrossRef
    • Effect of rifaximin on gut-lung axis in mice infected with influenza A virus
      Yafei Chen, Zuoyi Jiang, Zhihai Lei, Jihui Ping, Juan Su
      Comparative Immunology, Microbiology and Infectious Diseases.2021; 75: 101611.     CrossRef
    • Microbiota‐derived extracellular vesicles and metabolic syndrome
      Alexandre Villard, Jérôme Boursier, Ramaroson Andriantsitohaina
      Acta Physiologica.2021;[Epub]     CrossRef
    • Development of an in vitro coculture device for the investigation of host–microbe interactions via integrative multiomics approaches
      Won‐Suk Song, Sung Gyu Shin, Sung‐Hyun Jo, Jae‐Seung Lee, Hyo‐Jin Jeon, Ji‐Eun Kwon, Ji‐Hyeon Park, Sungwoo Cho, Jae Hyun Jeong, Byung‐Gee Kim, Yun‐Gon Kim
      Biotechnology and Bioengineering.2021; 118(4): 1593.     CrossRef
    • The role of inflammatory cytokines in anemia and gastrointestinal mucosal injury induced by foot electric stimulation
      Fangcheng Fan, Yangwen Ai, Ting Sun, Shuran Li, Hua Liu, Xiaojie Shi, Ziqian Zhang, Qingshan Liu, Yong Cheng
      Scientific Reports.2021;[Epub]     CrossRef
    • Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells
      Jens V. Stein, Nora Ruef, Stefanie Wissmann
      Frontiers in Immunology.2021;[Epub]     CrossRef
    • Quercetin Oxidation Metabolite Present in Onion Peel Protects Caco-2 Cells against the Oxidative Stress, NF-kB Activation, and Loss of Epithelial Barrier Function Induced by NSAIDs
      Jocelyn Fuentes, Adriano Costa de Camargo, Elías Atala, Martín Gotteland, Claudio Olea-Azar, Hernán Speisky
      Journal of Agricultural and Food Chemistry.2021; 69(7): 2157.     CrossRef
    • Gut microbiome, prebiotics, intestinal permeability and diabetes complications
      Matthew Snelson, Cassandra de Pasquale, Elif I. Ekinci, Melinda T. Coughlan
      Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(3): 101507.     CrossRef
    • Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis
      Jacob P. Veenstra, Bhaskar Vemu, Restituto Tocmo, Mirielle C. Nauman, Jeremy J. Johnson
      Nutrients.2021; 13(3): 773.     CrossRef
    • Protective effect of exopolysaccharide fraction from Bacillus subtilis against dextran sulfate sodium-induced colitis through maintenance of intestinal barrier and suppression of inflammatory responses
      Kyung-Sook Chung, Ji-Sun Shin, Jung-Hun Lee, Sang-Eun Park, Hee-Soo Han, Young Kyoung Rhee, Chang-Won Cho, Hee-Do Hong, Kyung-Tae Lee
      International Journal of Biological Macromolecules.2021; 178: 363.     CrossRef
    • Polysaccharides in natural products that repair the damage to intestinal mucosa caused by cyclophosphamide and their mechanisms: A review
      Cuiping Li, Shasha Duan, Yaping Li, Xiao Pan, Lirong Han
      Carbohydrate Polymers.2021; 261: 117876.     CrossRef
    • A food pyramid, based on a review of the emerging literature, for subjects with inflammatory bowel disease
      Mariangela Rondanelli, Silvia Lamburghini, Milena A. Faliva, Gabriella Peroni, Antonella Riva, Pietro Allegrini, Daniele Spadaccini, Clara Gasparri, Giancarlo Iannello, Vittoria Infantino, Tariq A. Alalwan, Simone Perna, Alessandra Miccono
      Endocrinología, Diabetes y Nutrición (English ed.).2021; 68(1): 17.     CrossRef
    • Systemic brain derived neurotrophic factor but not intestinal barrier integrity is associated with cognitive decline and incident Alzheimer’s disease
      Robin M. Voigt, Shohreh Raeisi, Jingyun Yang, Sue Leurgans, Christopher B. Forsyth, Aron S. Buchman, David A. Bennett, Ali Keshavarzian, Stephen D. Ginsberg
      PLOS ONE.2021; 16(3): e0240342.     CrossRef
    • Microbiota, renal disease and renal transplantation
      Maurizio Salvadori, Aris Tsalouchos
      World Journal of Transplantation.2021; 11(3): 16.     CrossRef
    • Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation
      Sheng Yin, Chao Sun, Yi Ji, Hamid Abdolmaleky, Jin-Rong Zhou
      Biomedicine & Pharmacotherapy.2021; 138: 111426.     CrossRef
    • Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring
      Qi‐chen Yuan, Han Gong, Min Du, Xue‐ying Mao
      The FASEB Journal.2021;[Epub]     CrossRef
    • Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats
      Fatma Akar, Esra Sumlu, Mehmet Eray Alçığır, Aykut Bostancı, Gökhan Sadi
      Food Research International.2021; 143: 110287.     CrossRef
    • Evaluation of the efficacy of probiotic VSL#3 and synbiotic VSL#3 and yacon‐based product in reducing oxidative stress and intestinal permeability in mice induced to colorectal carcinogenesis
      Bruna Cristina dos Santos Cruz, Luís Fernando de Sousa Moraes, Letícia De Nadai Marcon, Kelly Aparecida Dias, Leonardo Borges Murad, Mariáurea Matias Sarandy, Lisiane Lopes da Conceição, Reggiani Vilela Gonçalves, Célia Lúcia de Luces Fortes Ferreira, Mar
      Journal of Food Science.2021; 86(4): 1448.     CrossRef
    • Anethole Attenuates Enterotoxigenic Escherichia coli-Induced Intestinal Barrier Disruption and Intestinal Inflammation via Modification of TLR Signaling and Intestinal Microbiota
      Qingyuan Yi, Jiaxin Liu, Yufeng Zhang, Hanzhen Qiao, Fang Chen, Shihai Zhang, Wutai Guan
      Frontiers in Microbiology.2021;[Epub]     CrossRef
    • The effect of hypergravity in intestinal permeability of nanoformulations and molecules
      Cláudia Azevedo, Maria Helena Macedo, Andreia Almeida, Soraia Pinto, Jack J.W.A. van Loon, Bruno Sarmento
      European Journal of Pharmaceutics and Biopharmaceutics.2021; 163: 38.     CrossRef
    • Dietary supplementation of dried plum: a novel strategy to mitigate heat stress in broiler chickens
      Sanjeev Wasti, Nirvay Sah, Amit K. Singh, Chin N. Lee, Rajesh Jha, Birendra Mishra
      Journal of Animal Science and Biotechnology.2021;[Epub]     CrossRef
    • Antiviral Properties of Human Milk
      Sophie I. S. Wedekind, Natalie S. Shenker
      Microorganisms.2021; 9(4): 715.     CrossRef
    • Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR‐miR‐429 pathway
      Yuyao Chu, Yanrong Zhu, Yajing Zhang, Xiaojing Liu, Yilei Guo, Lan Chang, Xinming Yun, Zhifeng Wei, Yufeng Xia, Yue Dai
      The FASEB Journal.2021;[Epub]     CrossRef
    • Seaweed polysaccharide mitigates intestinal barrier dysfunction induced by enterotoxigenic Escherichia coli through NF‐κB pathway suppression in porcine intestinal epithelial cells
      Xiaobo Guo, Jun Chen, Jin Yang, Qin He, Bowen Luo, Yafei Lu, Tiande Zou, Zirui Wang, Jinming You
      Journal of Animal Physiology and Animal Nutrition.2021; 105(6): 1063.     CrossRef
    • Dietary Fiber Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Function Damage in Piglets by Modulation of Intestinal Microbiome
      Xiao Sun, Yalei Cui, Yingying Su, Zimin Gao, Xinying Diao, Ju Li, Xiaoyan Zhu, Defeng Li, Zhentian Li, Chengzhang Wang, Yinghua Shi, Hiutung Chu
      mSystems.2021;[Epub]     CrossRef
    • Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease
      Magdalena K. Stoeva, Jeewon Garcia-So, Nicholas Justice, Julia Myers, Surabhi Tyagi, Madeleine Nemchek, Paul J. McMurdie, Orville Kolterman, John Eid
      Gut Microbes.2021;[Epub]     CrossRef
    • A Novel Role of A2AR in the Maintenance of Intestinal Barrier Function of Enteric Glia from Hypoxia-Induced Injury by Combining with mGluR5
      Lihua Sun, Xiang Li, Haidi Guan, Shuaishuai Chen, Xin Fan, Chao Zhou, Hua Yang, Weidong Xiao
      Frontiers in Pharmacology.2021;[Epub]     CrossRef
    • Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice
      Chenyang Lu, Ju Chen, Congmin Yi, Jiaojiao Han, Qiuyue Shi, Jingjing Li, Bing Liu, Jun Zhou, Xiurong Su
      Food & Function.2021; 12(12): 5387.     CrossRef
    • Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota
      Zhen Shi, Zhi-yuan Fang, Xin-xing Gao, Hao Yu, Yi-wei Zhu, Hui-lin Ouyang, Yu-xiang Song, Xi-liang Du, Zhe Wang, Xin-wei Li, Guo-wen Liu
      Food & Function.2021; 12(13): 5850.     CrossRef
    • Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity
      Hui Wang, Nivedita Banerjee, Yuejin Liang, Gangduo Wang, Kristi L. Hoffman, M. Firoze Khan
      Toxicology and Applied Pharmacology.2021; 424: 115597.     CrossRef
    • Tilapia head glycolipids protect mice against dextran sulfate sodium-induced colitis by ameliorating the gut barrier and suppressing NF-kappa B signaling pathway
      Zhipeng Gu, Yujie Zhu, Fengfeng Mei, Xiuping Dong, Guanghua Xia, Xuanri Shen
      International Immunopharmacology.2021; 96: 107802.     CrossRef
    • Abdominal paracentesis drainage attenuates intestinal mucosal barrier damage through macrophage polarization in severe acute pancreatitis
      Xiaohui Yuan, Chen Luo, Jun Wu, Wei Li, Xin Guo, Shuai Li, Bing Wang, Hongyu Sun, Lijun Tang
      Experimental Biology and Medicine.2021; 246(18): 2029.     CrossRef
    • Corni fructus Extracts of Prebiotics Property and Cell Protective Effect on LPS-Induced Human Colon Epithelial Cell
      Hyo Lim Lee, Uk Lee, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Gil Han Kim, Min Ji Kim, Jong Hyun Moon, Hye Rin Jeong, Hyo Won Park, Ho Jin Heo
      Journal of the Korean Society of Food Science and Nutrition.2021; 50(5): 445.     CrossRef
    • Lactobacillus ruminis Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation
      Bo Yang, Mingjie Li, Shuo Wang, R. Paul Ross, Catherine Stanton, Jianxin Zhao, Hao Zhang, Wei Chen
      Foods.2021; 10(6): 1349.     CrossRef
    • Kaempferol attenuates diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells
      Yuhang Jin, Zhian Zhai, Hai Jia, Jinhua Lai, Xuemeng Si, Zhenlong Wu
      Food & Function.2021; 12(15): 6889.     CrossRef
    • Effects of Wine and Its Microbial-Derived Metabolites on Intestinal Permeability Using Simulated Gastrointestinal Digestion/Colonic Fermentation and Caco-2 Intestinal Cell Models
      Irene Zorraquín-Peña, Diego Taladrid, Alba Tamargo, Mariana Silva, Natalia Molinero, Dolores González de Llano, Begoña Bartolomé, M. Victoria Moreno-Arribas
      Microorganisms.2021; 9(7): 1378.     CrossRef
    • Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model
      Li Gu, Feng Ren, Xianrui Fang, Lianwen Yuan, Ganglei Liu, Shalong Wang
      Frontiers in Medicine.2021;[Epub]     CrossRef
    • Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets
      Chunyan Xie, Yumei Zhang, Kaimin Niu, Xiaoxiao Liang, Haihua Wang, Junwei Shan, Xin Wu
      Animal Nutrition.2021; 7(3): 641.     CrossRef
    • Therapeutic effect of Schisandrin A on avian colibacillosis through gut-liver axis
      Jialu Bao, Yan Zhang, Linchao Zhang, Xincheng Gong, Wanyu Shi, Liantao Liu, Xiaodan Wang
      Poultry Science.2021; 100(10): 101371.     CrossRef
    • Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro
      Yanni Li, Xiao Li, Chong Geng, Yaoyu Guo, Chunhui Wang
      Molecular and Cellular Endocrinology.2021; 535: 111390.     CrossRef
    • Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract
      Yolanda Ber, Santiago García-Lopez, Carla J. Gargallo-Puyuelo, Fernando Gomollón
      Nutrients.2021; 13(7): 2325.     CrossRef
    • Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD
      Maria Victoria Fernandez-Cantos, Diego Garcia-Morena, Valeria Iannone, Hani El-Nezami, Marjukka Kolehmainen, Oscar P. Kuipers
      Tissue Barriers.2021;[Epub]     CrossRef
    • Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability
      Shiv Bolan, Balaji Seshadri, Simon Keely, Anitha Kunhikrishnan, Jessica Bruce, Ian Grainge, Nicholas J. Talley, Ravi Naidu
      Scientific Reports.2021;[Epub]     CrossRef
    • Neutrophil extracellular traps in inflammatory bowel diseases: Implications in pathogenesis and therapeutic targets
      Anderson dos Santos Ramos, Giovana Cristina Santana Viana, Marcelo de Macedo Brigido, Juliana Franco Almeida
      Pharmacological Research.2021; 171: 105779.     CrossRef
    • Dietary supplementation of alpha-lipoic acid mitigates the negative effects of heat stress in broilers
      Sanjeev Wasti, Nirvay Sah, Chin N. Lee, Rajesh Jha, Birendra Mishra, Arda Yildirim
      PLOS ONE.2021; 16(7): e0254936.     CrossRef
    • Probiotic Supplementation for Rheumatoid Arthritis: A Promising Adjuvant Therapy in the Gut Microbiome Era
      Margarida Ferro, Sofia Charneca, Eduardo Dourado, Catarina Sousa Guerreiro, João Eurico Fonseca
      Frontiers in Pharmacology.2021;[Epub]     CrossRef
    • Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice
      Jodi E. Nettleton, Teja Klancic, Alana Schick, Ashley C. Choo, Ning Cheng, Jane Shearer, Stephanie L. Borgland, Jong M. Rho, Raylene A. Reimer
      Microorganisms.2021; 9(9): 1833.     CrossRef
    • Enzyme-Treated Soybean Meal Enhanced Performance via Improving Immune Response, Intestinal Morphology and Barrier Function of Nursery Pigs in Antibiotic Free Diets
      Shenfei Long, Jiayu Ma, Xiangshu Piao, Yuxin Li, Simone Husballe Rasmussen, Li Liu
      Animals.2021; 11(9): 2600.     CrossRef
    • The preventive effect and underlying mechanism ofRhus chinensisMill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
      Yi Zhang, Ou Wang, Nan Ma, Junjie Yi, Hongying Mi, Shengbao Cai
      Food & Function.2021; 12(20): 9965.     CrossRef
    • Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells
      Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
      Nutrients.2021; 13(9): 3152.     CrossRef
    • Ageratina adenophora Disrupts the Intestinal Structure and Immune Barrier Integrity in Rats
      Yujing Cui, Samuel Kumi Okyere, Pei Gao, Juan Wen, Suizhong Cao, Ya Wang, Junliang Deng, Yanchun Hu
      Toxins.2021; 13(9): 651.     CrossRef
    • PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells
      Dipanjana Ghosh, Ankita Dutta, Anjali Kashyap, Neeraj Upmanyu, Sunando Datta
      Journal of Cell Science.2021;[Epub]     CrossRef
    • A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
      Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus, Elizabeth J. Kovacs
      Immunity & Ageing.2021;[Epub]     CrossRef
    • Role of Barrier Integrity and Dysfunctions in Maintaining the Healthy Gut and Their Health Outcomes
      Shruti Panwar, Sapna Sharma, Prabhanshu Tripathi
      Frontiers in Physiology.2021;[Epub]     CrossRef
    • Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based <italic>in vitro</italic> monolayer model by activating MAPK pathway
      Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Jin
      Acta Biochimica et Biophysica Sinica.2021; 53(11): 1459.     CrossRef
    • Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model
      Bi-Ying Jin, Zhen Li, Ya-Nan Xia, Li-Xiang Li, Zi-Xiao Zhao, Xiao-Yu Li, Yan Li, Bing Li, Ru-Chen Zhou, Shi-Chen Fu, Shi-Yang Li, Yan-Qing Li
      Frontiers in Immunology.2021;[Epub]     CrossRef
    • Coral-Derived Endophytic Fungal Product, Butyrolactone-I, Alleviates Lps Induced Intestinal Epithelial Cell Inflammatory Response Through TLR4/NF-κB and MAPK Signaling Pathways: An in vitro and in vivo Studies
      Shengwei Chen, Yi Zhang, Xueting Niu, Sahar Ghulam Mohyuddin, Jiayin Wen, Minglong Bao, Tianyue Yu, Lianyun Wu, Canyin Hu, Yanhong Yong, Xiaoxi Liu, A. M. Abd El-Aty, Xianghong Ju
      Frontiers in Nutrition.2021;[Epub]     CrossRef
    • Recombinant CRAMP-producing Lactococcus lactis attenuates dextran sulfate sodium-induced colitis by colonic colonization and inhibiting p38/NF-κB signaling
      Jiahong Li, Shiwen Yu, Xiaohua Pan, Ming Zhang, Zhuwu Lv, Li-Long Pan, Jia Sun
      Food & Nutrition Research.2021;[Epub]     CrossRef
    • The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis
      Havvanur Yoldaş İlktaç, Nihal Büyükuslu, Cüneyd Parlayan
      Food and Health.2021; 7(4): 279.     CrossRef
    • P16INK4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency
      Jiawen Zhou, Chenxing Hou, Haiyun Chen, Ziyue Qin, Zi’an Miao, Jingyu Zhao, Qiuyi Wang, Min Cui, Chunfeng Xie, Rong Wang, Qing Li, Guoping Zuo, Dengshun Miao, Jianliang Jin
      Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
    • Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet‐Induced Obese Male Mice
      Tariful Islam, Iurii Koboziev, Kembra Albracht‐Schulte, Brandon Mistretta, Shane Scoggin, Mohammad Yosofvand, Hanna Moussa, Masoud Zabet‐Moghaddam, Latha Ramalingam, Preethi H. Gunaratne, Naima Moustaid‐Moussa
      Molecular Nutrition & Food Research.2021;[Epub]     CrossRef
    • Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model
      Young Min Kim, Zahid Hussain, Young Ju Lee, Hyojin Park
      Journal of Neurogastroenterology and Motility.2021; 27(4): 639.     CrossRef
    • Pediococcus pentosaceus IM96 Exerts Protective Effects against Enterohemorrhagic Escherichia coli O157:H7 Infection In Vivo
      Haixin Li, Xinqiang Xie, Ying Li, Moutong Chen, Liang Xue, Juan Wang, Jumei Zhang, Shi Wu, Qinghua Ye, Shuhong Zhang, Runshi Yang, Hui Zhao, Lei Wu, Tingting Liang, Yu Ding, Qingping Wu
      Foods.2021; 10(12): 2945.     CrossRef
    • Extracellular Vesicles Derived From Citrus sinensis Modulate Inflammatory Genes and Tight Junctions in a Human Model of Intestinal Epithelium
      Stefania Paola Bruno, Alessandro Paolini, Valentina D'Oria, Angelo Sarra, Simona Sennato, Federico Bordi, Andrea Masotti
      Frontiers in Nutrition.2021;[Epub]     CrossRef
    • The Microbiota and Kidney Transplantation: Influence on the Graft
      Maurizio Salvadori, Aris Tsalouchos
      EMJ Urology.2021; : 95.     CrossRef
    • MicroRNA Expression and Intestinal Permeability in Children Living in a Slum Area of Bangladesh
      Humaira Rashid, Towfida J. Siddiqua, Biplob Hossain, Abdullah Siddique, Mamun Kabir, Zannatun Noor, Masud Alam, Mamun Ahmed, Rashidul Haque
      Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
    • The Protective Effects of Lactoferrin on Aflatoxin M1-Induced Compromised Intestinal Integrity
      Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
      International Journal of Molecular Sciences.2021; 23(1): 289.     CrossRef
    • Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine
      Hasnaa Ali Ebrahim, Dalia Mahmoud Abdelmonem Elsherbini
      Cells Tissues Organs.2021; 210(4): 275.     CrossRef
    • Isolation and Characterization of Blueberry Polyphenolic Components and Their Effects on Gut Barrier Dysfunction
      Michael A. Polewski, Daniel Esquivel-Alvarado, Nicholas S. Wedde, Christian G. Kruger, Jess D. Reed
      Journal of Agricultural and Food Chemistry.2020; 68(10): 2940.     CrossRef
    • Polyphenols and Intestinal Permeability: Rationale and Future Perspectives
      Stefano Bernardi, Cristian Del Bo’, Mirko Marino, Giorgio Gargari, Antonio Cherubini, Cristina Andrés-Lacueva, Nicole Hidalgo-Liberona, Gregorio Peron, Raúl González-Dominguez, Paul Kroon, Benjamin Kirkup, Marisa Porrini, Simone Guglielmetti, Patrizia Ris
      Journal of Agricultural and Food Chemistry.2020; 68(7): 1816.     CrossRef
    • Painful interactions: Microbial compounds and visceral pain
      I.A.M. van Thiel, S. Botschuijver, W.J. de Jonge, J. Seppen
      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(1): 165534.     CrossRef
    • Autophagy induction by rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice
      Jie Zhao, Honggang Wang, Haojun Yang, Yan Zhou, Liming Tang
      International Immunopharmacology.2020; 81: 105977.     CrossRef
    • Acmella oleracea for pain management
      Mariangela Rondanelli, Federica Fossari, Viviana Vecchio, Valentina Braschi, Antonella Riva, Pietro Allegrini, Giovanna Petrangolini, Giancarlo Iannello, Milena Anna Faliva, Gabriella Peroni, Mara Nichetti, Clara Gasparri, Daniele Spadaccini, Vittoria Inf
      Fitoterapia.2020; 140: 104419.     CrossRef
    • Potential Determinants of Gastrointestinal Dysfunction in Autism Spectrum Disorders
      Anya E. Shindler, Elisa L. Hill-Yardin, Steve Petrovski, Anne C. Cunningham, Naomi Bishop, Ashley E. Franks
      Review Journal of Autism and Developmental Disorders.2020; 7(2): 182.     CrossRef
    • Protective Effect of Naringin on In Vitro Gut-Vascular Barrier Disruption of Intestinal Microvascular Endothelial Cells Induced by TNF-α
      Ping Liu, Yifei Bian, Yingsai Fan, Jia Zhong, Zhongjie Liu
      Journal of Agricultural and Food Chemistry.2020; 68(1): 168.     CrossRef
    • A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease
      Miao Sun, Kai Ma, Jie Wen, Guangxian Wang, Changliang Zhang, Qi Li, Xiaofeng Bao, Hui Wang
      Journal of Alzheimer's Disease.2020; 73(3): 849.     CrossRef
    • Soybean antigen protein induces caspase-3/mitochondrion-regulated apoptosis in IPEC-J2 cells
      Chenglu Peng, Zhifeng Sun, Lei Wang, Yingshuang Shu, Mengchu He, Hongyan Ding, Yu Li, Xichun Wang, Shibin Feng, Jinchun Li, Jinjie Wu
      Food and Agricultural Immunology.2020; 31(1): 100.     CrossRef
    • Oxidized Pork Induces Oxidative Stress and Inflammation by Altering Gut Microbiota in Mice
      Yueting Ge, Shiman Lin, Bowen Li, Yuhui Yang, Xue Tang, Yonghui Shi, Jin Sun, Guowei Le
      Molecular Nutrition & Food Research.2020;[Epub]     CrossRef
    • Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex
      Ju Yup Lee, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Sun Min Lee, Chin-Hee Song, Geun Kim, Hee Young Na, Yoon Jin Choi, Jin Joo Kim, Dong Ho Lee
      Journal of Neurogastroenterology and Motility.2020; 26(1): 106.     CrossRef
    • Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study
      Chang Hee Jeong, Hyuk Cheol Kwon, Do Hyun Kim, Wei Nee Cheng, Sukyung Kang, Dong-Min Shin, Jong Hyeok Yune, Jee Eun Yoon, You Hyun Chang, Hyejin Sohn, Sung Gu Han
      Environmental Health Perspectives.2020;[Epub]     CrossRef
    • Tuna Bone Powder Alleviates Glucocorticoid‐Induced Osteoporosis via Coregulation of the NF‐κB and Wnt/β‐Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism
      Jingjing Li, Mingyuan Yang, Chenyang Lu, Jiaojiao Han, Shasha Tang, Jun Zhou, Ye Li, Tinghong Ming, Zaijie Jim Wang, Xiurong Su
      Molecular Nutrition & Food Research.2020;[Epub]     CrossRef
    • Impact of high dietary plant protein with or without marine ingredients in gut mucosa proteome of gilthead seabream (Sparus aurata, L.)
      Guillem Estruch, Silvia Martínez-Llorens, Ana Tomás-Vidal, Raquel Monge-Ortiz, Miguel Jover-Cerdá, Paul B. Brown, David S. Peñaranda
      Journal of Proteomics.2020; 216: 103672.     CrossRef
    • QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health
      Emily A Beck, Mark C Currey, Clayton M Small, William A Cresko
      G3 Genes|Genomes|Genetics.2020; 10(2): 613.     CrossRef
    • Wuchereria bancrofti macrophage migration inhibitory factor‐2 (rWbaMIF‐2) ameliorates experimental colitis
      Shriram Ramani, Nikhil Chauhan, Vishal Khatri, Connie Vitali, Ramaswamy Kalyanasundaram
      Parasite Immunology.2020;[Epub]     CrossRef
    • Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice
      Ailing Liu, Hong Lv, Hongying Wang, Hong Yang, Yue Li, Jiaming Qian, Rozalyn Anderson
      The Journals of Gerontology: Series A.2020; 75(7): 1284.     CrossRef
    • Notch controls urothelial integrity in the mouse bladder
      Varvara Paraskevopoulou, Vangelis Bonis, Vasilis S. Dionellis, Nikolaos Paschalidis, Pelagia Melissa, Evangelia Chavdoula, Eleni Vasilaki, Ioannis S. Pateras, Apostolos Klinakis
      JCI Insight.2020;[Epub]     CrossRef
    • Investigating the gut-brain axis in a neurodevelopmental rodent model of schizophrenia
      Max W. Katz-Barber, Sharon L. Hollins, Annalisa Cuskelly, Angeline J.W. Leong, Ariel Dunn, Lauren Harms, Deborah M. Hodgson
      Brain, Behavior, & Immunity - Health.2020; 3: 100048.     CrossRef
    • Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression
      Kıvılcım Karadeniz Cerit, Türkan Koyuncuoğlu, Damla Yağmur, İrem Peker Eyüboğlu, Serap Şirvancı, Mustafa Akkiprik, Burak Aksu, E. Tolga Dağlı, Berrak Ç. Yeğen
      Journal of Pediatric Surgery.2020; 55(12): 2797.     CrossRef
    • tRNA Queuosine Modification Enzyme Modulates the Growth and Microbiome Recruitment to Breast Tumors
      Jilei Zhang, Rong Lu, Yongguo Zhang, Żaneta Matuszek, Wen Zhang, Yinglin Xia, Tao Pan, Jun Sun
      Cancers.2020; 12(3): 628.     CrossRef
    • Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models
      Raphaël Cornu, Claire Chrétien, Yann Pellequer, Hélène Martin, Arnaud Béduneau
      Archives of Toxicology.2020; 94(4): 1191.     CrossRef
    • Effect of peritoneal dialysis solution with different pyruvate concentrations on intestinal injury
      Jing-Jing Zhang, Hui-Qin Shen, Jiang-Tao Deng, Lin-Lin Jiang, Qiong-Yue Zhang, Ying Xiong, Zong-Ze Zhang, Yan-Lin Wang
      Experimental Biology and Medicine.2020; 245(7): 644.     CrossRef
    • Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation
      Hana. M.A. Fakhoury, Peter R. Kvietys, Wael AlKattan, Fatme Al Anouti, Muhammad Affan Elahi, Spyridon N. Karras, William B. Grant
      The Journal of Steroid Biochemistry and Molecular Biology.2020; 200: 105663.     CrossRef
    • Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice
      Yuxin Cheng, Ting Wu, Shuxin Tang, Fuqiang Liang, Yajing Fang, Weiwei Cao, Siyi Pan, Xiaoyun Xu
      Food & Function.2020; 11(4): 3167.     CrossRef
    • A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota
      Chunxiao Ren, Yijiang Wang, Xiaofeng Lin, Hanqing Song, Qiqi Zhou, Wan Xu, Kui Shi, Jun Chen, Junshuai Song, Fang Chen, Shihai Zhang, Wutai Guan
      Journal of Agricultural and Food Chemistry.2020; 68(14): 4155.     CrossRef
    • cis9,trans11, but nottrans10,cis12 CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice through activation of GPR120-[Ca2+]iand the MLCK signaling pathway
      Han Su, Weijie Zhao, Fenglin Zhang, Min Song, Fangfang Liu, Jisong Zheng, Mingfa Ling, Xiaohua Yang, Qiang Yang, Haiwen He, Lin Chen, Xumin Lai, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
      Food & Function.2020; 11(4): 3657.     CrossRef
    • Transport, metabolism and remedial potential of functional food extracts (FFEs) in Caco-2 cells monolayer: A review
      Maryam Iftikhar, Asra Iftikhar, Huijuan Zhang, Lingxiao Gong, Jing Wang
      Food Research International.2020; 136: 109240.     CrossRef
    • Nanosphere-shaped ammonio methacrylate copolymers: converting a pharmaceutical inactive ingredient to efficient therapeutics for experimental colitis
      Brice Moulari, Maryam A. Shetab Boushehri, Jean-Paul Pais de Barros, Thilo Faber, Arnaud Béduneau, Laurent Lagrost, Yann Pellequer, Alf Lamprecht
      Nanoscale.2020; 12(17): 9590.     CrossRef
    • Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells
      Wei Li, Mingbo Gao, Ting Han
      Food & Function.2020; 11(4): 3741.     CrossRef
    • Knockdown of ghrelin‐O‐acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium
      Peiying Tian, Xiaolan Lu, Nuyun Jin, Jianping Shi
      Cell Biology International.2020; 44(8): 1681.     CrossRef
    • Dynamics of Intestinal Inflammatory Cytokines and Tight Junction Proteins of Turbot (Scophthalmus maximus L.) During the Development and Recovery of Enteritis Induced by Dietary β-Conglycinin
      Jing Zheng, Pei Yang, Jihong Dai, Guijuan Yu, Weihao Ou, Weiqi Xu, Kangsen Mai, Yanjiao Zhang
      Frontiers in Marine Science.2020;[Epub]     CrossRef
    • Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex
      Ju Yup Lee, Nayoung Kim, Yoon Jin Choi, Ji Hyun Park, Hassan Ashktorab, Duane T Smoot, Dong Ho Lee
      Journal of Neurogastroenterology and Motility.2020; 26(2): 248.     CrossRef
    • Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles
      Xin Wu, Lu‐Min Gao, Yi‐Lin Liu, Chunyan Xie, Lichuang Cai, Kang Xu, Xi‐Hong Zhou
      Journal of the Science of Food and Agriculture.2020; 100(9): 3709.     CrossRef
    • Microphysiological Engineering of Immune Responses in Intestinal Inflammation
      Yoko M. Ambrosini, Woojung Shin, Soyoun Min, Hyun Jung Kim
      Immune Network.2020;[Epub]     CrossRef
    • Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction
      Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
      Food & Function.2020; 11(5): 4456.     CrossRef
    • Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model
      Brittany Woodby, Maria Lucia Schiavone, Erika Pambianchi, Angela Mastaloudis, Shelly N. Hester, Steven M. Wood, Alessandra Pecorelli, Giuseppe Valacchi
      International Journal of Environmental Research and Public Health.2020; 17(9): 3234.     CrossRef
    • Tri-n-butyl phosphate induced earthworm intestinal damage by influencing nutrient absorption and energy homeostasis of intestinal epithelial cells
      Yang Yang, Peng Liu, Mei Li
      Journal of Hazardous Materials.2020; 398: 122850.     CrossRef
    • Inhibitory Effects of Carrageenans on Endotoxin-Induced Inflammation
      Irina M. Yermak, Aleksandra V. Volod’ko, Eleonora I. Khasina, Viktoriya N. Davydova, Evgeniy A. Chusovitin, Dmitry L. Goroshko, Anna O. Kravchenko, Tamara F. Solov’eva, Victor V. Maleev
      Marine Drugs.2020; 18(5): 248.     CrossRef
    • Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets
      Hao Zhang, Yanan Chen, Yueping Chen, Shuli Ji, Peilu Jia, Yue Li, Tian Wang
      Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
    • Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF‐α and IL‐8 secretion
      Abhinav Sharma, Vishnu Raman, Jungwoo Lee, Neil S. Forbes
      Biotechnology and Bioengineering.2020; 117(8): 2540.     CrossRef
    • Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and attenuation of intestinal barrier disruption
      Dongxu Wang, Min Cai, Taotao Wang, Tiantian Liu, Jinbao Huang, Yijun Wang, Daniel Granato
      Food Research International.2020; 137: 109409.     CrossRef
    • The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet
      Yujun Liu, Yuan Gao, Fenglian Ma, Mengying Sun, Guangqing Mu, Yanfeng Tuo
      Food & Function.2020; 11(6): 5024.     CrossRef
    • Cyanobacterial lipopeptides puwainaphycins and minutissamides induce disruptive and pro-inflammatory processes in Caco-2 human intestinal barrier model
      Ondřej Vašíček, Jan Hájek, Lucie Bláhová, Pavel Hrouzek, Pavel Babica, Lukáš Kubala, Lenka Šindlerová
      Harmful Algae.2020; 96: 101849.     CrossRef
    • Dietary fermented soybean meal inclusion improves growth performance and ileal barrier function of the weaned piglets challenged by enterotoxigenic Escherichia coli K88
      Yuan Wang, Wenwen Wang, Ruifang Wang, Xiran Hao, Yuanxiao Duan, Ziqi Meng, Xiaoping An, Jingwei Qi
      Animal Feed Science and Technology.2020; 268: 114596.     CrossRef
    • Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis
      Mi-Young Shin, Cheng-Chung Yong, Sejong Oh
      Foods.2020; 9(7): 864.     CrossRef
    • Interactive effect of dietary calcium and phytase on broilers challenged with subclinical necrotic enteritis: part 2. Gut permeability, phytate ester concentrations, jejunal gene expression, and intestinal morphology
      H.K. Zanu, S.K. Kheravii, N.K. Morgan, M.R. Bedford, R.A. Swick
      Poultry Science.2020; 99(10): 4914.     CrossRef
    • The intestinal microbiota in psoriasis
      Monika Koper, Anna Woźniacka, Ewa Robak
      Postępy Higieny i Medycyny Doświadczalnej.2020; 74: 236.     CrossRef
    • Effects of the polysaccharide SPS-3-1 purified from Spirulina on barrier integrity and proliferation of Caco-2 cells
      Qun Wang, Fei Liu, Xuexiang Chen, Zhijie Yang, Yong Cao
      International Journal of Biological Macromolecules.2020; 163: 279.     CrossRef
    • Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro
      Shirley Arbizu, Boon Chew, Susanne U. Mertens-Talcott, Giuliana Noratto
      Food & Function.2020; 11(7): 5842.     CrossRef
    • Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish
      Camila J. Solis, M. Kristina Hamilton, Mario Caruffo, Juan P. Garcia-Lopez, Paola Navarrete, Karen Guillemin, Carmen G. Feijoo
      Frontiers in Immunology.2020;[Epub]     CrossRef
    • Pulmonary arterial hypertension-associated changes in gut pathology and microbiota
      Ravindra K. Sharma, Aline C. Oliveira, Tao Yang, Seungbum Kim, Jasenka Zubcevic, Victor Aquino, Gilberto O. Lobaton, Ruby Goel, Elaine M. Richards, Mohan K. Raizada
      ERJ Open Research.2020; 6(3): 00253-2019.     CrossRef
    • Anti-Inflammatory Properties of Mineral-Balanced Deep Sea Water in In-Vitro and In-Vivo Models of Inflamed Intestinal Epithelium
      Jain Nam, Kyeong Jin Kim, Geonhee Park, Byeong Goo Kim, Gwi-Hwa Jeong, Jong-eun Jeon, Byung Serk Hurh, Ji Yeon Kim
      Applied Sciences.2020; 10(15): 5183.     CrossRef
    • Barrier Protection and Recovery Effects of Gut Commensal Bacteria on Differentiated Intestinal Epithelial Cells In Vitro
      Nooshin Mohebali, Katharina Ekat, Bernd Kreikemeyer, Anne Breitrück
      Nutrients.2020; 12(8): 2251.     CrossRef
    • Changes in intestinal barrier functions and gut microbiota in rats exposed to zearalenone
      Wei Zhang, Shihua Zhang, Jingjing Wang, Anshan Shan, Li Xu
      Ecotoxicology and Environmental Safety.2020; 204: 111072.     CrossRef
    • Acute Diarrhea in Dogs: Current Management and Potential Role of Dietary Polyphenols Supplementation
      Alessia Candellone, Matteo Cerquetella, Flavia Girolami, Paola Badino, Rosangela Odore
      Antioxidants.2020; 9(8): 725.     CrossRef
    • Bacteria Remediate the Effects of Food Additives on Intestinal Function in an in vitro Model of the Gastrointestinal Tract
      Mridu Malik, Sanjeena Subedi, Cláudia N. H. Marques, Gretchen J. Mahler
      Frontiers in Nutrition.2020;[Epub]     CrossRef
    • Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis
      Che Othman Siti Sarah, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong
      PeerJ.2020; 8: e9834.     CrossRef
    • Maintaining intestinal structural integrity is a potential protective mechanism against inflammation in goose fatty liver
      Wang Gu, Kang Wen, Chunchi Yan, Shuo Li, Tongjun Liu, Cheng Xu, Long Liu, Minmeng Zhao, Jun Zhang, Tuoyu Geng, Daoqing Gong
      Poultry Science.2020; 99(11): 5297.     CrossRef
    • PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease
      Apor Veres-Székely, Mária Bernáth, Domonkos Pap, Réka Rokonay, Beáta Szebeni, István M. Takács, Rita Lippai, Áron Cseh, Attila J. Szabó, Ádám Vannay
      Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
    • Intestinal epithelium integrity after delayed onset of nutrition in broiler chickens
      M.S. Hollemans, J. van Baal, G. de Vries Reilingh, B. Kemp, A. Lammers, S. de Vries
      Poultry Science.2020; 99(12): 6818.     CrossRef
    • Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease
      Lluïsa Miró, Concepció Amat, Cristina Rosell-Cardona, Joy M. Campbell, Javier Polo, Anna Pérez-Bosque, Miquel Moretó
      International Journal of Molecular Sciences.2020; 21(18): 6760.     CrossRef
    • Development of an Improved 3D in vitro Intestinal Model to Perform Permeability Studies of Paracellular Compounds
      Maria Helena Macedo, Elena Martínez, Cristina C. Barrias, Bruno Sarmento
      Frontiers in Bioengineering and Biotechnology.2020;[Epub]     CrossRef
    • Protective Effect of Glycomacropeptide on Food Allergy with Gastrointestinal Manifestations in a Rat Model through Down-Regulation of Type 2 Immune Response
      Diana Reyes-Pavón, Daniel Cervantes-García, Luis G. Bermúdez-Humarán, Laura Elena Córdova-Dávalos, Andrés Quintanar-Stephano, Mariela Jiménez, Eva Salinas
      Nutrients.2020; 12(10): 2942.     CrossRef
    • Expression profile of lncRNAs and mRNAs in intestinal macrophages
      Qais Naseer, Lulu Liu, Xiaofei Xue, Siche Chen, Jixiang Chen, Jianguo Qu, Lei Cui, Xiaogang Wang, Shengchun Dang
      Molecular Medicine Reports.2020;[Epub]     CrossRef
    • Noninvasive Biomarkers of Gut Barrier Function in Patients Suffering from Diarrhea Predominant-IBS: An Update
      Michele Linsalata, Giuseppe Riezzo, Caterina Clemente, Benedetta D’Attoma, Francesco Russo, Roberta Rizzo
      Disease Markers.2020; 2020: 1.     CrossRef
    • Docosahexaenoic acid alleviates cell injury and improves barrier function by suppressing necroptosis signalling in TNF-α-challenged porcine intestinal epithelial cells
      Kan Xiao, Qiao Xu, Congcong Liu, Pengwei He, Qin Qin, Huiling Zhu, Jing Zhang, Ashley Gin, Guolong Zhang, Yulan Liu
      Innate Immunity.2020; 26(8): 653.     CrossRef
    • In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice
      Mbiantcha Marius, Dawe Amadou, Atsamo Albert Donatien, Ateufack Gilbert, Yousseu Nana William, Khalid Rauf, Mehreen Arif, Fanta Yadang Sabine Adeline, Njoku Isaac Saint, Hamza Dar, Naeem Ur Rehman, Izhar Ahmad, Paolo Gionchetti
      Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
    • Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium
      Mariya A. Borisova, Kseniya M. Achasova, Ksenia N. Morozova, Evgeniya N. Andreyeva, Ekaterina A. Litvinova, Anna A. Ogienko, Maryana V. Morozova, Mariya B. Berkaeva, Elena Kiseleva, Elena N. Kozhevnikova
      Scientific Reports.2020;[Epub]     CrossRef
    • Severe acute respiratory syndrome coronavirus‐2 infection and the gut–liver axis
      Sundhar Mohandas, Balasubramaniyan Vairappan
      Journal of Digestive Diseases.2020; 21(12): 687.     CrossRef
    • Significance of vagus nerve function in terms of pathogenesis of psychosocial disorders
      Yoshihiko Kakinuma
      Neurochemistry International.2020; : 104934.     CrossRef
    • A method for rapid generation of model intestinal barriers in vitro
      SV Nikulin, AA Poloznikov, DA Sakharov
      Bulletin of Russian State Medical University.2020;[Epub]     CrossRef
    • A combined microphysiological-computational omics approach in dietary protein evaluation
      Paulus G. M. Jochems, Willem R. Keusters, Antoine H. P. America, Pascale C. S. Rietveld, Shanna Bastiaan-Net, Renata M. C. Ariëns, Monic M. M. Tomassen, Fraser Lewis, Yang Li, Koen G. C. Westphal, Johan Garssen, Harry J. Wichers, Jeroen van Bergenhenegouw
      npj Science of Food.2020;[Epub]     CrossRef
    • Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
      Tennekoon B. Karunaratne, Chijioke Okereke, Marissa Seamon, Sharad Purohit, Chandramohan Wakade, Amol Sharma
      Nutrients.2020; 13(1): 28.     CrossRef
    • Gut-Induced Inflammation during Development May Compromise the Blood-Brain Barrier and Predispose to Autism Spectrum Disorder
      Rebecca S. Eshraghi, Camron Davies, Rahul Iyengar, Linda Perez, Rahul Mittal, Adrien A. Eshraghi
      Journal of Clinical Medicine.2020; 10(1): 27.     CrossRef
    • Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds – A comprehensive review
      Amlan Kumar Patra, Salah Amasheh, Jörg Rudolf Aschenbach
      Critical Reviews in Food Science and Nutrition.2019; 59(20): 3237.     CrossRef
    • Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model
      Keiko Igaki, Yoshiki Nakamura, Yusaku Komoike, Keiko Uga, Akira Shibata, Yoshimasa Ishimura, Masashi Yamasaki, Yasuhiro Tsukimi, Noboru Tsuchimori
      Inflammation.2019; 42(1): 91.     CrossRef
    • Osteopontin Protects Colonic Mucosa from Dextran Sodium Sulfate-Induced Acute Colitis in Mice by Regulating Junctional Distribution of Occludin
      Sang-Ho Woo, Su-Hyung Lee, Jun-Won Park, Du-Min Go, Dae-Yong Kim
      Digestive Diseases and Sciences.2019; 64(2): 421.     CrossRef
    • An insight into gut microbiota and its functionalities
      Atanu Adak, Mojibur R. Khan
      Cellular and Molecular Life Sciences.2019; 76(3): 473.     CrossRef
    • MicroRNAs and signaling networks involved in epithelial–mesenchymal transition
      Mohammad Hossein Musavi Shenas, Shadi Eghbal‐Fard, Vahid Mehrisofiani, Nima Abd Yazdani, Omid Rahbar Farzam, Faroogh Marofi, Mehdi Yousefi
      Journal of Cellular Physiology.2019; 234(5): 5775.     CrossRef
    • Purification and identification of intestinal mucosal cell proliferation-promoting peptides from Crassostrea hongkongensis
      Jianyu Pan, Peng Wan, Deke Chen, Hua Chen, Xin Chen, Huili Sun, Bingna Cai
      European Food Research and Technology.2019; 245(3): 631.     CrossRef
    • The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome
      Aref Shariati, Fateme Fallah, Ali Pormohammad, Ali Taghipour, Hossein Safari, Alireza salami chirani, Sahar Sabour, Mahmood Alizadeh‐Sani, Taher Azimi
      Journal of Cellular Physiology.2019; 234(6): 8550.     CrossRef
    • Acute effects of milk polar lipids on intestinal tight junction expression: towards an impact of sphingomyelin through the regulation of IL-8 secretion?
      Marine Milard, Armelle Penhoat, Annie Durand, Charline Buisson, Emmanuelle Loizon, Emmanuelle Meugnier, Karène Bertrand, Florent Joffre, David Cheillan, Lorna Garnier, Sébastien Viel, Fabienne Laugerette, Marie-Caroline Michalski
      The Journal of Nutritional Biochemistry.2019; 65: 128.     CrossRef
    • Resveratrol improves intestinal barrier function, alleviates mitochondrial dysfunction and induces mitophagy in diquat challenged piglets1
      Shuting Cao, Zhuojun Shen, Chunchun Wang, Qianhui Zhang, Qihua Hong, Yonghui He, Caihong Hu
      Food & Function.2019; 10(1): 344.     CrossRef
    • The In Vitro Protective Role of Bovine Lactoferrin on Intestinal Epithelial Barrier
      Xiao Zhao, Xiao-Xi Xu, Yang Liu, En-Ze Xi, Jing-Jing An, Dina Tabys, Ning Liu
      Molecules.2019; 24(1): 148.     CrossRef
    • Effect of caseinate glycation with oligochitosan and transglutaminase on the intestinal barrier function of the tryptic caseinate digest in IEC-6 cells
      Jia Shi, Xin-Huai Zhao
      Food & Function.2019; 10(2): 652.     CrossRef
    • A Role of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis
      Yun Chen, Ming Zhang, Fazheng Ren
      Molecules.2019; 24(3): 513.     CrossRef
    • Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation
      Carla Nunes, Víctor Freitas, Leonor Almeida, João Laranjinha
      Food & Function.2019; 10(3): 1364.     CrossRef
    • Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease
      Rasha H. Dosh, Nicola Jordan-Mahy, Christopher Sammon, Christine L. Le Maitre
      Scientific Reports.2019;[Epub]     CrossRef
    • Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
      Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri
      Metabolic Brain Disease.2019; 34(2): 385.     CrossRef
    • Collagen peptides administration in early enteral nutrition intervention attenuates burn-induced intestinal barrier disruption: Effects on tight junction structure
      Qianru Chen, Xiang Gao, Hongwei Zhang, Bafang Li, Guangli Yu, Bo Li
      Journal of Functional Foods.2019; 55: 167.     CrossRef
    • Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell–Cell Junctions
      Diana Schuhmacher, Jean-Marie Sontag, Estelle Sontag
      Frontiers in Cell and Developmental Biology.2019;[Epub]     CrossRef
    • The Influence of Heat-Killed Enterococcus faecium BGPAS1-3 on the Tight Junction Protein Expression and Immune Function in Differentiated Caco-2 Cells Infected With Listeria monocytogenes ATCC 19111
      Nikola Popović, Jelena Djokić, Emilija Brdarić, Miroslav Dinić, Amarela Terzić-Vidojević, Nataša Golić, Katarina Veljović
      Frontiers in Microbiology.2019;[Epub]     CrossRef
    • Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance
      Yi-Fang Chen, Jin-Juan Zheng, Chao Qu, Yao Xiao, Fang-Fang Li, Quan-Xin Jin, Hong-Hua Li, Fan-Ping Meng, Gui-Hua Jin, Dan Jin
      Artificial Cells, Nanomedicine, and Biotechnology.2019; 47(1): 757.     CrossRef
    • N-(1-carbamoyl-2-phenylethyl) butyramide reduces antibiotic-induced intestinal injury, innate immune activation and modulates microbiota composition
      Adriano Lama, Chiara Annunziata, Lorena Coretti, Claudio Pirozzi, Francesca Di Guida, Allegra Nitrato Izzo, Claudia Cristiano, Maria Pina Mollica, Lorenzo Chiariotti, Alessandra Pelagalli, Francesca Lembo, Rosaria Meli, Giuseppina Mattace Raso
      Scientific Reports.2019;[Epub]     CrossRef
    • Influence of the Maillard-type caseinate glycation with lactose on the intestinal barrier activity of the caseinate digest in IEC-6 cells
      Jia Shi, Xin-Huai Zhao
      Food & Function.2019; 10(4): 2010.     CrossRef
    • Anti-inflammatory effect of Lycium barbarum on polarized human intestinal epithelial cells
      So-Rok Lee, Hye-Jeong Hwang, Ju-Gyeong Yoon, Eun Young Bae, Kyo-Suk Goo, Sang-Joon Cho, Jin Ah Cho
      Nutrition Research and Practice.2019; 13(2): 95.     CrossRef
    • Unexplained inflammation in end‐stage kidney disease: Is the combination of enhanced gastrointestinal permeability and reticuloendothelial dysfunction its cause?
      Oscar Swift, Enric Vilar, Ken Farrington
      Seminars in Dialysis.2019; 32(5): 417.     CrossRef
    • Lactoferrin in Aseptic and Septic Inflammation
      Maria Stefania Lepanto, Luigi Rosa, Rosalba Paesano, Piera Valenti, Antimo Cutone
      Molecules.2019; 24(7): 1323.     CrossRef
    • Mechanisms by Which the Gut Microbiota Influences Cytokine Production and Modulates Host Inflammatory Responses
      Viviani Mendes, Izabela Galvão, Angelica Thomaz Vieira
      Journal of Interferon & Cytokine Research.2019; 39(7): 393.     CrossRef
    • High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers
      Wajiha Gohir, Katherine M. Kennedy, Jessica G. Wallace, Michelle Saoi, Christian J. Bellissimo, Philip Britz‐McKibbin, Jim J. Petrik, Michael G. Surette, Deborah M. Sloboda
      The Journal of Physiology.2019; 597(12): 3029.     CrossRef
    • Dietary probiotic form modulates broiler gut microbiota indices and expression of gut barrier genes including essential components for gut homeostasis
      Konstantinos C. Mountzouris, Irida Palamidi, Vasileios Paraskeuas, Eirini Griela, Konstantinos Fegeros
      Journal of Animal Physiology and Animal Nutrition.2019; 103(4): 1143.     CrossRef
    • Bacillus licheniformis Zhengchangsheng® attenuates DSS-induced colitis and modulates the gut microbiota in mice
      Y. Li, M. Liu, J. Zhou, B. Hou, X. Su, Z. Liu, J. Yuan, M. Li
      Beneficial Microbes.2019; 10(5): 543.     CrossRef
    • A Fixed Combination of Probiotics and Herbal Extracts Attenuates Intestinal Barrier Dysfunction from Inflammatory Stress in an In vitro Model Using Caco-2 Cells
      Veronica Cocetta, Daniela Catanzaro, Vittoria Borgonetti, Eugenio Ragazzi, Maria C. Giron, Paolo Governa, Ilaria Carnevali, Marco Biagi, Monica Montopoli
      Recent Patents on Food, Nutrition & Agriculture.2019; 10(1): 62.     CrossRef
    • The administration of Escherichia coli Nissle 1917 ameliorates irinotecan–induced intestinal barrier dysfunction and gut microbial dysbiosis in mice
      Yurong Wang, Lie Sun, Shanwen Chen, Shihao Guo, Taohua Yue, Qisheng Hou, Mei Feng, Hao Xu, Yucun Liu, Pengyuan Wang, Yisheng Pan
      Life Sciences.2019; 231: 116529.     CrossRef
    • Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation
      Huifang Wang, Qiuxiang Zhang, Yuhan Niu, Xin Zhang, Rongrong Lu
      International Journal of Biological Macromolecules.2019; 136: 27.     CrossRef
    • Extracellular vesicles and soluble factors secreted by Escherichia coli Nissle 1917 and ECOR63 protect against enteropathogenic E. coli-induced intestinal epithelial barrier dysfunction
      Carina-Shianya Alvarez, Rosa Giménez, María-Alexandra Cañas, Rodrigo Vera, Natalia Díaz-Garrido, Josefa Badia, Laura Baldomà
      BMC Microbiology.2019;[Epub]     CrossRef
    • Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens
      Yuanyuan Wu, Wenrui Zhen, Yanqiang Geng, Zhong Wang, Yuming Guo
      Scientific Reports.2019;[Epub]     CrossRef
    • β-Conglycinin-Induced Intestinal Porcine Epithelial Cell Damage via the Nuclear Factor κB/Mitogen-Activated Protein Kinase Signaling Pathway
      Chenglu Peng, Xuedong Ding, Lei Zhu, Mengchu He, Yingshuang Shu, Yu Zhang, Yu Li, Xichun Wang, Shibin Feng, Jinchun Li, Jinjie Wu
      Journal of Agricultural and Food Chemistry.2019; 67(32): 9009.     CrossRef
    • Occludin endocytosis is involved in the disruption of the intestinal epithelial barrier in a mouse model of alcoholic steatohepatitis
      Hong Yan Wang, Cheng Chi, You Qing Xu, Chen Wang, Tian Yi Wang, Dong Lv, Xin Li
      Journal of Digestive Diseases.2019; 20(9): 476.     CrossRef
    • Biomaterial–tight junction interaction and potential impacts
      Xiangfei Han, Ershuai Zhang, Yuanjie Shi, Boyi Song, Hong Du, Zhiqiang Cao
      Journal of Materials Chemistry B.2019; 7(41): 6310.     CrossRef
    • Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage
      Shiyu Tao, Yu Bai, Tiantian Li, Na Li, Junjun Wang
      The FASEB Journal.2019; 33(9): 9897.     CrossRef
    • Activation of epithelial cells by the major kiwifruit allergen Act d 1 in human and mouse-derived intestinal model
      Andrijana Nešić, Annemarie Stam, Milena Čavić, Jean Paul Ten Klooster, Raymond Pieters, Joost Smit, Marija Gavrović-Jankulović
      Journal of Functional Foods.2019; 62: 103556.     CrossRef
    • Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities
      Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Catherine Mazza, Michael Berk
      Pharmacological Research.2019; 148: 104450.     CrossRef
    • Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
      Yongfeng Bai, Siwei Wang, Wenkai Xu, Yuanyuan Weng, Shengmei Zhu, Hao Sheng, Jin Zhu, Feng Zhang, François Blachier
      PLOS ONE.2019; 14(9): e0223231.     CrossRef
    • Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
      Stavroula Baritaki, Eelco de Bree, Ekaterini Chatzaki, Charalabos Pothoulakis
      Journal of Clinical Medicine.2019; 8(10): 1669.     CrossRef
    • Intestinal anti-inflammatory activity of xique–xique (Pilosocereus gounelleiA. Weber ex K. Schum. Bly. Ex Rowl) juice on acetic acid-induced colitis in rats
      Paloma Oliveira Antonino de Assis, Gerlane Coelho Bernardo Guerra, Daline Fernandes de Souza Araújo, Leylliane de Fátima Leal Interaminense de Andrade, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo, Thaís Gomes de Carvalho, Maria de Fátima Vand
      Food & Function.2019; 10(11): 7275.     CrossRef
    • AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells
      Séverine Olivier, Jocelyne Leclerc, Adrien Grenier, Marc Foretz, Jérôme Tamburini, Benoit Viollet
      International Journal of Molecular Sciences.2019; 20(20): 5171.     CrossRef
    • Risk factors for peritonitis in patients on continuous ambulatory peritoneal dialysis who undergo colonoscopy: a retrospective multicentre study
      Tae-Geun Gweon, Sung Hoon Jung, Sang Woo Kim, Kang-Moon Lee, Dae Young Cheung, Bo-In Lee, Hwang Choi
      BMC Gastroenterology.2019;[Epub]     CrossRef
    • Effects of dietary fiber sources during late gestation and lactation on sow performance, milk quality, and intestinal health in piglets1
      Qinghui Shang, Hansuo Liu, Sujie Liu, Tengfei He, Xiangshu Piao
      Journal of Animal Science.2019; 97(12): 4922.     CrossRef
    • Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function
      Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yongli Hua, Yanming Wei
      Frontiers in Pharmacology.2019;[Epub]     CrossRef
    • Endotoxemia And Intestinal Barrier Disorders Associated With Overweight And Obesity
      Agata Janczy, Zdzisław Kochan, Sylwia Małgorzewicz
      Postępy Mikrobiologii - Advancements of Microbiology.2019; 58(4): 427.     CrossRef
    • Tight joints and zonulin in the formation of oral tolerance and food allergy
      N. G. Prikhodchenko, T. A. Shumatova, L. A. Grigoryan, A. V. Gordeets
      Pacific Medical Journal.2019; (4): 5.     CrossRef
    • Anthocyanins and intestinal barrier function: a review
      Jonathan C. Valdez, Bradley W. Bolling
      Journal of Food Bioactives.2019; : 18.     CrossRef
    • The role of polymorphonuclear neutrophils during HIV-1 infection
      Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Mohammad Mahmoud Yaseen, Barakat Mohammad Shabsoug
      Archives of Virology.2018; 163(1): 1.     CrossRef
    • Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression
      Min Woo Kim, Seungho Choi, Sun Yeou Kim, Yeo Sung Yoon, Ju-Hee Kang, Seung Hyun Oh
      International Journal of Molecular Sciences.2018; 19(7): 2025.     CrossRef
    • Retinoic Acid, Leaky Gut, and Autoimmune Diseases
      Leila Abdelhamid, Xin Luo
      Nutrients.2018; 10(8): 1016.     CrossRef
    • The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?
      Camille Pochard, Sabrina Coquenlorge, Marie Freyssinet, Philippe Naveilhan, Arnaud Bourreille, Michel Neunlist, Malvyne Rolli-Derkinderen
      American Journal of Physiology-Gastrointestinal and Liver Physiology.2018; 315(1): G1.     CrossRef
    • Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells
      Koji Matsuhisa, Akihiro Watari, Kazuki Iwamoto, Masuo Kondoh, Kiyohito Yagi
      Journal of Natural Medicines.2018; 72(2): 448.     CrossRef
    • Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
      Zhiqiang Li, Inamul Kabir, Gladys Tietelman, Chongmin Huan, Jianglin Fan, Tilla Worgall, Xian-Cheng Jiang
      Cell Death & Disease.2018;[Epub]     CrossRef
    • The role of the gut microbiota in the pathology and prevention of liver disease
      Alejandra Altamirano-Barrera, Misael Uribe, Norberto C. Chávez-Tapia, Natalia Nuño-Lámbarri
      The Journal of Nutritional Biochemistry.2018; 60: 1.     CrossRef
    • Rhamnogalacturonan, a chemically-defined polysaccharide, improves intestinal barrier function in DSS-induced colitis in mice and human Caco-2 cells
      Daniele Maria-Ferreira, Adamara Machado Nascimento, Thales Ricardo Cipriani, Arquimedes Paixão Santana-Filho, Paulo da Silva Watanabe, Debora de Mello Gonçales Sant´Ana, Fernando Bittencourt Luciano, Karla Carolina Paiva Bocate, René M. van den Wijngaard,
      Scientific Reports.2018;[Epub]     CrossRef
    • Effect of Oxidized Soybean Oils on Oxidative Status and Intestinal Barrier Function in Broiler Chickens
      L Tan, D Rong, Y Yang, B Zhang
      Brazilian Journal of Poultry Science.2018; 20(2): 333.     CrossRef
    • Lactobacillus reuteristrains protect epithelial barrier integrity of IPEC-J2 monolayers from the detrimental effect of enterotoxigenicEscherichia coli
      Shokoufeh Karimi, Hans Jonsson, Torbjörn Lundh, Stefan Roos
      Physiological Reports.2018; 6(2): e13514.     CrossRef
    • Direct peritoneal resuscitation reduces intestinal permeability after brain death
      Jessica L. Weaver, Paul J. Matheson, Amy Matheson, Victoria Graham, Brian G. Harbrecht, Cynthia D. Downard, R. Neal Garrison, Jason W. Smith
      Journal of Trauma and Acute Care Surgery.2018; 84(2): 265.     CrossRef
    • Effects of lactobacilli with different regulatory behaviours on tight junctions in mice with dextran sodium sulphate-induced colitis
      Gang Wang, Qi Xu, Xing Jin, Feng Hang, Zhenmin Liu, Jianxin Zhao, Hao Zhang, Wei Chen
      Journal of Functional Foods.2018; 47: 107.     CrossRef
    • ERK1/2-mediated autophagy is essential for cell survival under Ochratoxin A exposure in IPEC-J2 cells
      Hong Wang, Hu Li, Xingxiang Chen, Kehe Huang
      Toxicology and Applied Pharmacology.2018; 360: 38.     CrossRef
    • Temperature-treated gluten proteins in Gluten-Friendly™ bread increase mucus production and gut-barrier function in human intestinal goblet cells
      Carmela Lamacchia, Daniela Musaico, Mary E. Henderson, Triana Bergillos-Meca, Morgane Roul, Loretta Landriscina, Ivana Decina, Giulia Corona, Adele Costabile
      Journal of Functional Foods.2018; 48: 507.     CrossRef
    • Oregonin inhibits inflammation and protects against barrier disruption in intestinal epithelial cells
      Jin-Hua Chi, Geom Seog Seo, Sung Hee Lee
      International Immunopharmacology.2018; 59: 134.     CrossRef
    • The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery
      Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen
      Expert Review of Gastroenterology & Hepatology.2018; 12(3): 223.     CrossRef
    • AhR activation protects intestinal epithelial barrier function through regulation of Par-6
      Kun Yu, Yuanhang Ma, Zhicao Zhang, Xin Fan, Teming Li, Liangzi Li, Weidong Xiao, Yujiao Cai, Lihua Sun, Pengyuan Xu, Min Yu, Hua Yang
      Journal of Molecular Histology.2018; 49(5): 449.     CrossRef
    • The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier
      Milica Vujicic, Tamara Saksida, Sanja Despotovic, Svetlana Sokovic Bajic, Ivana Lalić, Ivan Koprivica, Dragica Gajic, Natasa Golic, Maja Tolinacki, Ivana Stojanovic
      Scientific Reports.2018;[Epub]     CrossRef
    • Predictors and clinical outcomes of follow‐up loss in patients with inflammatory bowel disease
      Dae Hyung Woo, Kyeong Ok Kim, Min Kyu Kang, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
      Journal of Gastroenterology and Hepatology.2018; 33(11): 1834.     CrossRef
    • Protective Effects of Salvianolic Acid A against Dextran Sodium Sulfate-Induced Acute Colitis in Rats
      Kai Wang, Qinqin Yang, Quanxin Ma, Bei Wang, Zhengrui Wan, Minli Chen, Liming Wu
      Nutrients.2018; 10(6): 791.     CrossRef
    • Protective Role of Coxsackie-Adenovirus Receptor in the Pathogenesis of Inflammatory Bowel Diseases
      Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
      BioMed Research International.2018; 2018: 1.     CrossRef
    • Gut Barrier Dysfunction—A Primary Defect in Twins with Crohn’s Disease Predominantly Caused by Genetic Predisposition
      Åsa V Keita, Carl Mårten Lindqvist, Åke Öst, Carlos D L Magana, Ida Schoultz, Jonas Halfvarson
      Journal of Crohn's and Colitis.2018; 12(10): 1200.     CrossRef
    • The role of gastrointestinal permeability in food allergy
      Nazanin Samadi, Martina Klems, Eva Untersmayr
      Annals of Allergy, Asthma & Immunology.2018; 121(2): 168.     CrossRef
    • MicroRNA in gastrointestinal cell signalling
      Priyanka Mishra, Divya Singh, Lilly Ganju, Bhuvnesh Kumar
      Inflammopharmacology.2018; 26(1): 1.     CrossRef
    • Functional sequencing read annotation for high precision microbiome analysis
      Chengsheng Zhu, Maximilian Miller, Srinayani Marpaka, Pavel Vaysberg, Malte C Rühlemann, Guojun Wu, Femke-Anouska Heinsen, Marie Tempel, Liping Zhao, Wolfgang Lieb, Andre Franke, Yana Bromberg
      Nucleic Acids Research.2018; 46(4): e23.     CrossRef
    • Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway
      Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding
      Mediators of Inflammation.2018; 2018: 1.     CrossRef
    • The Effect of Prim-O-Glucosylcimifugin on Tryptase-Induced Intestinal Barrier Dysfunction in Caco-2 Cells
      Lu Xu, Jieyi Cai, Aofei Tian, Kai Qian, Renan Qin, Shaoyun Qi, Xupeng Tan, Yuqin Qiu, Mengjuan Gong, Bin Han, Xuguang Hu
      Biological and Pharmaceutical Bulletin.2018; 41(9): 1355.     CrossRef
    • Alopecia areata and the gut—the link opens up for novel therapeutic interventions
      Annika Borde, Annika Åstrand
      Expert Opinion on Therapeutic Targets.2018; 22(6): 503.     CrossRef
    • Effects of Alpinetin on Intestinal Barrier Function, Inflammation and Oxidative Stress in Dextran Sulfate Sodium-Induced Ulcerative Colitis Mice
      Yue Tan, Changqing Zheng
      The American Journal of the Medical Sciences.2018; 355(4): 377.     CrossRef
    • IL‐1β induces increased tight junction permeability in bovine mammary epithelial cells via the IL‐1β‐ERK1/2‐MLCK axis upon blood‐milk barrier damage
      Tong Xu, Zhijian Dong, Xixi Wang, Shaopei Qi, Xueru Li, Rui Cheng, Xu Liu, Yong Zhang, Ming‐Qing Gao
      Journal of Cellular Biochemistry.2018; 119(11): 9028.     CrossRef
    • Leaky brain in neurological and psychiatric disorders: Drivers and consequences
      Gerwyn Morris, Brisa S Fernandes, Basant K Puri, Adam J Walker, Andre F Carvalho, Michael Berk
      Australian & New Zealand Journal of Psychiatry.2018; 52(10): 924.     CrossRef
    • Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
      Yoo Jin Lee, Zahid Hussain, Cheal Wung Huh, Young Ju Lee, Hyojin Park
      Journal of Neurogastroenterology and Motility.2018; 24(1): 147.     CrossRef
    • Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway
      Shasha He, Yuhong Guo, Jingxia Zhao, Xiaolong Xu, Jin Song, Ning Wang, Qingquan Liu
      International Journal of Hyperthermia.2018; 35(1): 112.     CrossRef
    • Probiotics and the Gut Immune System: Indirect Regulation
      Giorgio La Fata, Peter Weber, M. Hasan Mohajeri
      Probiotics and Antimicrobial Proteins.2018; 10(1): 11.     CrossRef
    • Pathophysiology of IBD associated diarrhea
      Arivarasu N. Anbazhagan, Shubha Priyamvada, Waddah A. Alrefai, Pradeep K. Dudeja
      Tissue Barriers.2018; 6(2): e1463897.     CrossRef
    • Acid‐Hydrolyzed Gliadins Worsen Food Allergies through Early Sensitization
      Laure Castan, Clélia Villemin, Mathilde Claude, Philippe Aubert, Tony Durand, Michel Neunlist, Chantal Brossard, Antoine Magnan, Marie Bodinier, Grégory Bouchaud
      Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
    • Resveratrol and inflammatory bowel disease: the evidence so far
      Sandra Nunes, Francesca Danesi, Daniele Del Rio, Paula Silva
      Nutrition Research Reviews.2018; 31(1): 85.     CrossRef
    • Molecular mechanisms of somatostatin-mediated intestinal epithelial barrier function restoration by upregulating claudin-4 in mice with DSS-induced colitis
      Lin Cai, Xiao Li, Chong Geng, Xuelian Lei, Chunhui Wang
      American Journal of Physiology-Cell Physiology.2018; 315(4): C527.     CrossRef
    • Micro-patterned endogenous stroma equivalent induces polarized crypt-villus architecture of human small intestinal epithelium
      Vincenza De Gregorio, Giorgia Imparato, Francesco Urciuolo, Paolo A. Netti
      Acta Biomaterialia.2018; 81: 43.     CrossRef
    • Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro
      Jin Hua Chi, Young Ho Kim, Dong Hwan Sohn, Geom Seog Seo, Sung Hee Lee
      Biomedicine & Pharmacotherapy.2018; 108: 1767.     CrossRef
    • Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants
      Bing Ma, Elias McComb, Pawel Gajer, Hongqiu Yang, Mike Humphrys, Adora C. Okogbule-Wonodi, Alessio Fasano, Jacques Ravel, Rose M Viscardi
      Frontiers in Microbiology.2018;[Epub]     CrossRef
    • Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2
      Paolo Governa, Maddalena Marchi, Veronica Cocetta, Bianca De Leo, Philippa T. K. Saunders, Daniela Catanzaro, Elisabetta Miraldi, Monica Montopoli, Marco Biagi
      Pharmaceuticals.2018; 11(4): 126.     CrossRef
    • Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses
      Alice H. Costain, Andrew S. MacDonald, Hermelijn H. Smits
      Frontiers in Immunology.2018;[Epub]     CrossRef
    • Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
      Bonggi Lee, Kyoung Mi Moon, Choon Young Kim
      Journal of Immunology Research.2018; 2018: 1.     CrossRef
    • Effects of 17beta;-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model
      Chin-Hee Song, Nayoung Kim, Sung Hwa Sohn, Sun Min Lee, Ryoung Hee Nam, Hee Young Na, Dong Ho Lee, Young-Joon Surh
      Gut and Liver.2018; 12(6): 682.     CrossRef
    • A Rodent Model of Anxiety: The Effect of Perinatal Immune Challenges on Gastrointestinal Inflammation and Integrity
      Sharon L. Hollins, Luke Brock, Rafael Barreto, Lauren Harms, Ariel Dunn, Pedro Garcia-Sobrinho, Jessica Bruce, Phillip W. Dickson, Marjorie M. Walker, Simon Keely, Deborah M. Hodgson
      Neuroimmunomodulation.2018; 25(3): 163.     CrossRef
    • Critical role of Keratin 1 in maintaining epithelial barrier and correlation of its down-regulation with the progression of inflammatory bowel disease
      Xiangqian Dong, Zichao Liu, Danfeng Lan, Junkun Niu, Jiarong Miao, Gang Yang, Fengrui Zhang, Yang Sun, Kunhua Wang, Yinglei Miao
      Gene.2017; 608: 13.     CrossRef
    • Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota
      Martin Liehr, Alessandro Mereu, Jose Javier Pastor, Jose Carlos Quintela, Stefanie Staats, Gerald Rimbach, Ignacio Rodolfo Ipharraguerre, Hauke Smidt
      PLOS ONE.2017; 12(3): e0174239.     CrossRef
    • Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease
      Bożena Cukrowska, Agnieszka Sowińska, Joanna Beata Bierła, Elżbieta Czarnowska, Anna Rybak, Urszula Grzybowska-Chlebowczyk
      World Journal of Gastroenterology.2017; 23(42): 7505.     CrossRef
    • Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling
      Chloé Terciolo, Aurélie Dobric, Mehdi Ouaissi, Carole Siret, Gilles Breuzard, Françoise Silvy, Bastien Marchiori, Sébastien Germain, Renaté Bonier, Adel Hama, Roisin Owens, Dominique Lombardo, Véronique Rigot, Frédéric André
      Journal of Crohn's and Colitis.2017; 11(8): 999.     CrossRef
    • Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options
      D. S. March, M. P. M. Graham-Brown, C. M. Stover, N. C. Bishop, J. O. Burton
      BioMed Research International.2017; 2017: 1.     CrossRef
    • Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice
      Ikram Aboura, Abdelhafid Nani, Meriem Belarbi, Babar Murtaza, Aurélie Fluckiger, Adélie Dumont, Chahid Benammar, Moufida Saidani Tounsi, François Ghiringhelli, Mickaël Rialland, Naim Akhtar Khan, Aziz Hichami
      Biomedicine & Pharmacotherapy.2017; 96: 1022.     CrossRef
    • Arsenic downregulates tight junction claudin proteins through p38 and NF-κB in intestinal epithelial cell line, HT-29
      Chang Hee Jeong, Jin Sil Seok, Michael C. Petriello, Sung Gu Han
      Toxicology.2017; 379: 31.     CrossRef
    • Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner
      Ju Yup Lee, Nayoung Kim, Ryoung Hee Nam, Sung Hwa Sohn, Sun Min Lee, Daeun Choi, Hyuk Yoon, Yong Sung Kim, Hye Seung Lee, Dong Ho Lee, Seungil Ro
      PLOS ONE.2017; 12(12): e0188992.     CrossRef
    • The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis
      Dana Elshaer, Jakob Begun
      Seminars in Cell & Developmental Biology.2017; 61: 51.     CrossRef
    • ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics
      Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xuewen Gou, Jamie Zhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang, Hong Liang, Huanlong Qin, Xiaoyang Wu
      Nature Communications.2017;[Epub]     CrossRef
    • Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases
      Sundhar Mohandas, Balasubramaniyan Vairappan
      World Journal of Hepatology.2017; 9(32): 1210.     CrossRef
    • The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice
      Marlies Elderman, Bruno Sovran, Floor Hugenholtz, Katrine Graversen, Myrte Huijskes, Eva Houtsma, Clara Belzer, Mark Boekschoten, Paul de Vos, Jan Dekker, Jerry Wells, Marijke Faas, Veena Taneja
      PLOS ONE.2017; 12(9): e0184274.     CrossRef
    • The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases
      Min-Hyun Kim, Hyeyoung Kim
      International Journal of Molecular Sciences.2017; 18(5): 1051.     CrossRef
    • Rebamipide ameliorates radiation-induced intestinal injury in a mouse model
      Sehwan Shim, Hyo-Sun Jang, Hyun-Wook Myung, Jae Kyung Myung, Jin-Kyu Kang, Min-Jung Kim, Seung Bum Lee, Won-Suk Jang, Sun-Joo Lee, Young-Woo Jin, Seung-Sook Lee, Sunhoo Park
      Toxicology and Applied Pharmacology.2017; 329: 40.     CrossRef
    • Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability
      Wei-Yang Chen, Min Wang, Jingwen Zhang, Shirish S. Barve, Craig J. McClain, Swati Joshi-Barve
      The American Journal of Pathology.2017; 187(12): 2686.     CrossRef
    • Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7
      Lonneke M. JanssenDuijghuijsen, Sander Grefte, Vincent C. J. de Boer, Lara Zeper, Dorien A. M. van Dartel, Inge van der Stelt, Melissa Bekkenkamp-Grovenstein, Klaske van Norren, Harry J. Wichers, Jaap Keijer
      Frontiers in Physiology.2017;[Epub]     CrossRef
    • Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2 cells
      HyunA Jo, Dahyun Hwang, Jeong-Keun Kim, Young-Hee Lim
      Food and Chemical Toxicology.2017; 108: 203.     CrossRef
    • From clinical uncertainties to precision medicine: the emerging role of the gut barrier and microbiome in small bowel functional diseases
      Wojciech Marlicz, Diana E Yung, Karolina Skonieczna-Żydecka, Igor Loniewski, Saskia van Hemert, Beata Loniewska, Anastasios Koulaouzidis
      Expert Review of Gastroenterology & Hepatology.2017; 11(10): 961.     CrossRef
    • Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model
      Tingting Chen, Choon Young Kim, Amandeep Kaur, Lisa Lamothe, Maliha Shaikh, Ali Keshavarzian, Bruce R. Hamaker
      Food & Function.2017; 8(3): 1166.     CrossRef
    • Berberine alleviates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress
      Li-Chao Zhang, Yue Wang, Ling-Chang Tong, Sheng Sun, Wei-Ye Liu, Su Zhang, Rong-Mei Wang, Zhi-Bin Wang, Ling Li
      Experimental and Therapeutic Medicine.2017; 13(6): 3374.     CrossRef
    • Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice
      Jahidul Islam, Takuya Koseki, Kouichi Watanabe, Ardiansyah, Slamet Budijanto, Akira Oikawa, Md Alauddin, Tomoko Goto, Hisahi Aso, Michio Komai, Hitoshi Shirakawa
      Nutrients.2017; 9(7): 747.     CrossRef
    • Petri Net-Based Model of Helicobacter pylori Mediated Disruption of Tight Junction Proteins in Stomach Lining during Gastric Carcinoma
      Anam Naz, Ayesha Obaid, Faryal M. Awan, Aqsa Ikram, Jamil Ahmad, Amjad Ali
      Frontiers in Microbiology.2017;[Epub]     CrossRef
    • The Effects of Direct-fed Microbial Supplementation, as an Alternative to Antibiotics, on Growth Performance, Intestinal Immune Status, and Epithelial Barrier Gene Expression in Broiler Chickens
      U. Gadde, S. T. Oh, Y. S. Lee, E. Davis, N. Zimmerman, T. Rehberger, Hyun S. Lillehoj
      Probiotics and Antimicrobial Proteins.2017; 9(4): 397.     CrossRef
    • Alpha-Melanocyte Stimulating Hormone Protects against Cytokine-Induced Barrier Damage in Caco-2 Intestinal Epithelial Monolayers
      Judit Váradi, András Harazin, Ferenc Fenyvesi, Katalin Réti-Nagy, Péter Gogolák, György Vámosi, Ildikó Bácskay, Pálma Fehér, Zoltán Ujhelyi, Gábor Vasvári, Eszter Róka, David Haines, Mária A. Deli, Miklós Vecsernyés, Zoltán Rakonczay
      PLOS ONE.2017; 12(1): e0170537.     CrossRef
    • Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model
      Jie Han, Ji-Hong Li, Guang Bai, Guo-Shun Shen, Jing Chen, Jia-Nan Liu, Shuo Wang, Xian-Jun Liu
      World Journal of Gastroenterology.2017; 23(12): 2175.     CrossRef
    • Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development
      Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter, Caroline J. Barelle
      Frontiers in Immunology.2017;[Epub]     CrossRef
    • Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease
      Elisabeth Norén, Sven Almer, Jan Söderman
      BMC Gastroenterology.2017;[Epub]     CrossRef
    • Protective effect of sugar cane extract against dextran sulfate sodium-induced colonic inflammation in mice
      Bin Wang, Yansen Li, Masami Mizu, Toma Furuta, ChunMei Li
      Tissue and Cell.2017; 49(1): 8.     CrossRef
    • Wasabia japonica is a potential functional food to prevent colitis via inhibiting the NF-κB signaling pathway
      Ju-Hee Kang, Seungho Choi, Jeong-Eun Jang, Prakash Ramalingam, Young Tag Ko, Sun Yeou Kim, Seung Hyun Oh
      Food & Function.2017; 8(8): 2865.     CrossRef
    • Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency
      Fraser L. Collins, Naiomy D. Rios-Arce, Shelby Atkinson, Hayley Bierhalter, Daniel Schoenherr, Jason N. Bazil, Laura R. McCabe, Narayanan Parameswaran
      Physiological Reports.2017; 5(9): e13263.     CrossRef
    • IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
      Yaya Wang, John Brian Mumm, Ronald Herbst, Roland Kolbeck, Yue Wang
      The Journal of Immunology.2017; 199(9): 3316.     CrossRef
    • Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells
      Sang-Hun Kim, Sun-Young Park, Young-Lan Park, Dae-Seong Myung, Jong-Sun Rew, Young-Eun Joo
      Molecular Medicine Reports.2017; 16(6): 9224.     CrossRef
    • Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
      Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
      The Journal of Nutritional Biochemistry.2017; 39: 126.     CrossRef
    • Effect of Conjugated Linoleic Acid-enriched Butter After 24 hours of Intestinal Mucositis Induction
      Patrícia Aparecida Vieira de Barros, Simone de Vasconcelos Generoso, Maria Emília Rabelo Andrade, Marco Antonio Sundfeld da Gama, Fernando Cesar Ferraz Lopes, Éricka Lorenna de Sales e Souza, Flaviano dos Santos Martins, Sued Eustáquio Mendes Miranda, Sim
      Nutrition and Cancer.2017; 69(1): 168.     CrossRef
    • Regulation of intestinal permeability: The role of proteases
      Hanne Van Spaendonk, Hannah Ceuleers, Leonie Witters, Eveline Patteet, Jurgen Joossens, Koen Augustyns, Anne-Marie Lambeir, Ingrid De Meester, Joris G De Man, Benedicte Y De Winter
      World Journal of Gastroenterology.2017; 23(12): 2106.     CrossRef
    • Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer
      Tiaosi Xing, Rolando Camacho Salazar, Yan-Hua Chen
      Tissue Barriers.2017; 5(4): e1356901.     CrossRef
    • Variants of β-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats
      Jérémie Bruno, Aurélie Nicolas, Sandra Pesenti, Jessica Schwarz, Jean-Luc Simon, Joëlle Léonil, Pascale Plaisancié
      Journal of Dairy Science.2017; 100(5): 3360.     CrossRef
    • The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium
      Jayashree Sarathy, Sally Jo Detloff, Mei Ao, Nabihah Khan, Sydney French, Hafsa Sirajuddin, Tanushree Nair, Mrinalini C. Rao
      Physiological Reports.2017;[Epub]     CrossRef
    • Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed a Western Diet
      Kai Wang, Xiaolu Jin, Mengmeng You, Wenli Tian, Richard Leu, David Topping, Michael Conlon, Liming Wu, Fuliang Hu
      Nutrients.2017; 9(8): 875.     CrossRef
    • Helicobacter suis induces changes in gastric inflammation and acid secretion markers in pigs of different ages
      C. De Witte, B. Devriendt, B. Flahou, I. Bosschem, R. Ducatelle, A. Smet, F. Haesebrouck
      Veterinary Research.2017;[Epub]     CrossRef
    • Vitamin D3 induces vitamin D receptor and HDAC11 binding to relieve the promoter of the tight junction proteins
      Feng-Hua Liu, Shan-Shan Li, Xiao-Xi Li , Shuai Wang , Mao-Gang Li , Li Guan, Tian-Gang Luan, Zhi-Gang Liu, Zhan-Ju Liu, Ping-Chang Yang
      Oncotarget.2017; 8(35): 58781.     CrossRef
    • Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway
      Zhongze Liu, Liangzi Li, Weigang Chen, Qimeng Wang, Weidong Xiao, Yuanhang Ma, Baifa Sheng, Xiang Li, Lihua Sun, Min Yu, Hua Yang
      International Journal of Molecular Medicine.2017;[Epub]     CrossRef
    • The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists
      Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine DiGuilio, Rima Dilbarova, Walker Alexander, George C. Prenderg
      Cancer Research.2017; 77(8): 1783.     CrossRef
    • The prevalence of bacterial overgrowth syndrome and its associated factors in patients with inflammatory bowel diseases (according to the data of the Novosibirsk registry)
      Yu A Kulygina, M F Osipenko, M I Skalinskaya, K D Palchunova
      Terapevticheskii arkhiv.2017; 89(2): 15.     CrossRef
    • The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model
      Dong Shin Kwak, Oh Young Lee, Kang Nyeong Lee, Dae Won Jun, Hang Lak Lee, Byung Chul Yoon, Ho Soon Choi
      Gut and Liver.2016;[Epub]     CrossRef
    • Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
      Loubna Abdel Hadi, Clara Di Vito, Laura Riboni
      Mediators of Inflammation.2016; 2016: 1.     CrossRef
    • Size-dependent nanoparticulate drug delivery in inflammatory bowel diseases
      John Youshia, Alf Lamprecht
      Expert Opinion on Drug Delivery.2016; 13(2): 281.     CrossRef
    • Lactobacillus acidophilusstimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells
      Shubha Priyamvada, Arivarasu N. Anbazhagan, Anoop Kumar, Vikas Soni, Waddah A. Alrefai, Ravinder K. Gill, Pradeep K. Dudeja, Seema Saksena
      American Journal of Physiology-Gastrointestinal and Liver Physiology.2016; 310(8): G599.     CrossRef
    • Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice
      Hongyu Zhao, Rui Yan, Xiaogang Zhou, Fang Ji, Bing Zhang
      International Immunopharmacology.2016; 39: 121.     CrossRef
    • Advances in nutritional therapy in inflammatory bowel diseases: Review
      Andrzej Wędrychowicz
      World Journal of Gastroenterology.2016; 22(3): 1045.     CrossRef
    • WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease
      Qi Zhang, Cuiping Zhang, Xiaoyu Li, Yanan Yu, Kun Liang, Xinzhi Shan, Kun Zhao, Qinghui Niu, Zibin Tian
      Disease Markers.2016; 2016: 1.     CrossRef
    • Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli
      Paul Ugalde-Silva, Octavio Gonzalez-Lugo, Fernando Navarro-Garcia
      Frontiers in Cellular and Infection Microbiology.2016;[Epub]     CrossRef
    • Effects of Supplementation of the Synbiotic Ecologic® 825/FOS P6 on Intestinal Barrier Function in Healthy Humans: A Randomized Controlled Trial
      E. Wilms, J. Gerritsen, H. Smidt, I. Besseling-van der Vaart, G. T. Rijkers, A. R. Garcia Fuentes, A. A. M. Masclee, F. J. Troost, John Green
      PLOS ONE.2016; 11(12): e0167775.     CrossRef
    • Adherens Junctions Modulate Diffusion between Epithelial Cells inTrichoplax adhaerens
      Carolyn L. Smith, Thomas S. Reese
      The Biological Bulletin.2016; 231(3): 216.     CrossRef
    • The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity
      Romina Fiorotto, Ambra Villani, Antonis Kourtidis, Roberto Scirpo, Mariangela Amenduni, Peter J. Geibel, Massimiliano Cadamuro, Carlo Spirli, Panos Z. Anastasiadis, Mario Strazzabosco
      Hepatology.2016; 64(6): 2118.     CrossRef
    • Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease
      Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Kenichi Watanabe
      Drug Discovery Today.2016; 21(5): 843.     CrossRef
    • Proteinaceous Molecules Mediating Bifidobacterium-Host Interactions
      Lorena Ruiz, Susana Delgado, Patricia Ruas-Madiedo, Abelardo Margolles, Borja Sánchez
      Frontiers in Microbiology.2016;[Epub]     CrossRef
    • Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome
      Bárbara S. Rocha, Carla Nunes, João Laranjinha
      The International Journal of Biochemistry & Cell Biology.2016; 81: 393.     CrossRef
    • Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease
      Yaron Ilan
      Clinical & Translational Immunology.2016;[Epub]     CrossRef
    • Matricellular Protein Periostin Mediates Intestinal Inflammation through the Activation of Nuclear Factor κB Signaling
      Seong-Joon Koh, Younjeong Choi, Byeong Gwan Kim, Kook Lae Lee, Dae Woo Kim, Jung Ho Kim, Ji Won Kim, Joo Sung Kim, Emiko Mizoguchi
      PLOS ONE.2016; 11(2): e0149652.     CrossRef
    • Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice
      Jing Xiong, Ming-feng Zhou, Ya-dong Wang, Li-ping Chen, Wan-fu Xu, Yao-dong Wang, Fan Deng, Si-de Liu
      Scientific Reports.2016;[Epub]     CrossRef
    • Effect of Long Noncoding RNA H19 Overexpression on Intestinal Barrier Function and Its Potential Role in the Pathogenesis of Ulcerative Colitis
      Shan-wen Chen, Peng-yuan Wang, Yu-cun Liu, Lie Sun, Jing Zhu, Shuai Zuo, Ju Ma, Teng-yu Li, Jun-ling Zhang, Guo-wei Chen, Xin Wang, Qiu-ru Zhu, You-wen Zheng, Ze-yang Chen, Zi-hao Yao, Yi-sheng Pan
      Inflammatory Bowel Diseases.2016; 22(11): 2582.     CrossRef
    • Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress
      Ling-chang Tong, Yue Wang, Zhi-bin Wang, Wei-ye Liu, Sheng Sun, Ling Li, Ding-feng Su, Li-chao Zhang
      Frontiers in Pharmacology.2016;[Epub]     CrossRef
    • Arctigenin fromFructus Arctii(Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers
      Hee Soon Shin, Sun Young Jung, Su Yeon Back, Jeong-Ryong Do, Dong-Hwa Shon
      Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
    • Polymorphisms inPRKCDBP, a Transcriptional Target of TNF-α, Are Associated With Inflammatory Bowel Disease in Korean
      Jung-Wook Kim, Chang Kyun Lee, Hyo Jong Kim, Jae-Jun Shim, Jae Young Jang, Seok Ho Dong, Byung-Ho Kim, Young Woon Chang, Sung-Gil Chi
      Intestinal Research.2015; 13(3): 242.     CrossRef
    • Soluble Syndecan-1: Does This Biomarker Address a Seemingly Insoluble Problem in Inflammatory Bowel Disease?
      Angela M. Patterson
      Digestive Diseases and Sciences.2015; 60(8): 2222.     CrossRef
    • Tight junction disruption:Helicobacter pyloriand dysregulation of the gastric mucosal barrier
      Tyler J Caron
      World Journal of Gastroenterology.2015; 21(40): 11411.     CrossRef
    • Nutritional Keys for Intestinal Barrier Modulation
      Stefania De Santis, Elisabetta Cavalcanti, Mauro Mastronardi, Emilio Jirillo, Marcello Chieppa
      Frontiers in Immunology.2015;[Epub]     CrossRef
    • Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial–Microbiota Interface
      Fernanda Schreiber, Julia Maryam Arasteh, Trevor D. Lawley
      Journal of Molecular Biology.2015; 427(23): 3676.     CrossRef
    • Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut
      Andrea Michielan, Renata D’Incà, Hannes Neuwirt
      Mediators of Inflammation.2015;[Epub]     CrossRef
    • Therapies from Fucoidan: An Update
      Janet Fitton, Damien Stringer, Samuel Karpiniec
      Marine Drugs.2015; 13(9): 5920.     CrossRef
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      Susanne Beyer, Aline Moosmann, Astrid S. Kahnt, Thomas Ulshöfer, Michael J. Parnham, Nerea Ferreirós, Sylvia Wagner, Matthias G. Wacker
      Pharmaceutical Research.2015; 32(12): 3986.     CrossRef
    • Arginyl-glutamine dipeptide attenuates experimental colitis by enhancing antioxidant function and inhibiting nuclear factor-kappaB
      Hua Yu, Mingjun Dong, Yidong Xu, Ning He, Xiaoyu Dai, Keqiang Li
      RSC Advances.2015; 5(112): 92008.     CrossRef

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      Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
      Intest Res. 2015;13(1):11-18.   Published online January 29, 2015
      DOI: https://doi.org/10.5217/ir.2015.13.1.11
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    Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
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    Fig. 1 Molecular structure of the intracellular junction of intestinal epithelial cells. The tight junctions (TJs), multiple protein complexes, locate at the apical ends of the lateral membranes of intestinal epithelial cells. The TJ complex consists of transmembrane and intracellular scaffold proteins. The transmembrane proteins (claudins, occludin, and junctional adhesion molecules [JAMs]) create a permselective barrier in the paracellular pathways. The intracellular domains of the transmembrane proteins interact with the intracellular scaffold proteins such as zonula occludens (ZO) proteins, which in turn anchor the transmembrane proteins to the actin cytoskeleton.
    Fig. 2 Interaction of proteins with the integral scaffold tight junction (TJ) proteins, zonula occludens (ZO)-1, -2, and -3. ZO proteins carry 3 post-synaptic density 95/Drosophila disc large/zona-occludens (PDZ) domains, a Src homology-3 (SH3) domain, and a region of homology to guanylate kinase (GUK) from the side of the N-terminus. Several TJ proteins and cytoskeletal actin interact with the ZO proteins. JAM-A, junctional adhesion molecule-A.

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    Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
    Intest Res : Intestinal Research
    © Korean Association for the Study of Intestinal Diseases.
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