Granular cell tumors (GCT) are rare tumors of neural origin involving mostly the tongue and skin. However, with the increased use of endoscopy, the gastrointestinal tract has been reported as a common location. the esophagus is the gastrointestinal site most frequently affected. Such tumors are rarely seen in the stomach, colon or rectum. It usually appears as a small, poorly circumscribed nodule with benign clinical course. Subsequently one case of a granular cell tumor of the ascending colon in 38 year-old female which were successfully diagnosed by a endoscopy and a endosonography and confirmed using snare polypectomy is here in reported. (Intestinal Research 2003;1:59-63)