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Intestinal Research 2003;1(1):72-82.
Published online May 27, 2003.
Familial Occurrence of Ulcerative Colitis in All 4 Family Members
Jeong-Sik Byeon, Suk-Kyun Yang, Yun Jung Lee, Jae Won Choe, Gin Hyug Lee, Seung-Jae Myung, Hwoon-Yong Jung, Weon-Seon Hong, Jin-Ho Kim, Young Il Min
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
일가족 4명 모두에서 발생한 가족성 궤양성 대장염
변정식, 양석균, 이윤정, 최재원, 이진혁, 명승재, 정훈용, 홍원선, 김진호, 민영일
울산대학교 의과대학 서울아산병원 내과학교실
Abstract
The pathogenesis of ulcerative colitis is complicated and both the genetic and environmental factors contribute to its development. Familial occurrence is an example indicating that both the genetic and environmental factors play some parts in the development of ulcerative colitis because family members have similar genetic characteristics and have been exposed to similar environment. Familial ulcerative colitis is observed in about 10% to 20% of patients. Most such families contain only 2 affected members and families containing more than 2 affected members are relatively rare. We experienced a case of familial ulcerative colitis in which all 4 members (both spouses and their 2 sons) were affected. They had lived together for 29 years before all 4 members were affected. The first patient was diagnosed after 14 years of cohabitation and the rest were affected 13, 14, and 15 years after the first diagnosis. We report this case with a review of literature. (Intestinal Research 2003;1:72-77)
Key Words: Familial occurrence,Ulcerative colitis
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