| Role of Peroxisome Proliferator-Activated Receptor g in Inflammatory Bowel Disease and Colon Cancer |
|
Sang Kil Lee, Hyo Jong Kim |
|
Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
|
| 염증성장질환과 대장암에서의 Peroxisome Proliferator-Activated Receptor γ의 역할 |
|
이상길, 김효종 |
|
경희대학교 의과대학 내과학교실 |
|
|
| Abstract |
|
The peroxisome proliferator-activated receptor γ (PPARγ) and its partner the retinoid X receptor (RXR) are two nuclear receptors that are expressed mainly in adipose tissue and which have a role in lipid metabolism and insulin sensitization. New sites of PPARγ expression have been described, especially in the intestinal tract. Concomitantly, new functions have been attributed to PPARγ in regulation of inflammation and carcinogenesis. These new functions of PPARγ have led to novel ideas about pathophysiology of inflammatory bowel disease and colon cancer to development of innovative treatment strategies with PPARγ agonist. (Intestinal Research 2004;2:53-57) |
| Key Words:
PPAR-γ, PPAR-γ agonist, Inflammatory bowel disease, Colon cancerv, PPAR-γ |
|
PDF Links
Full text via DOI
Download Citation
