Role of the CXC12-CXCR4 Axis and CXCL16 in Inflammatory Bowel Disease

Hiroshi Nakase; Minoru Matsuura; Sakae Mikami; Norimitsu Uza; Tsutomu Chiba

doi:10.5217/ir.2012.10.2.125

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Review Role of the CXC12-CXCR4 Axis and CXCL16 in Inflammatory Bowel Disease: Hiroshi Nakase, Minoru Matsuura, Sakae Mikami, Norimitsu Uza, Tsutomu Chiba; Intestinal Research 2012;10(2):125-133.
DOI: https://doi.org/10.5217/ir.2012.10.2.125
Published online: April 30, 2012

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Abstract

Numerous studies of colitis in IBD (inflammatory bowel diseases) patients and in animal models have demonstrated that both inflammatory cytokines and chemokines are up-regulated in settings of active inflammation. Blockade or absence of various cytokines and chemokines attenuates the disease in murine models of IBD. Therefore, identifying cytokines and chemokines involved in intestinal inflammation provide promising targets for the development of new drugs in the treatment of IBD. In general, chemokines have been implicated in many fundamental immune processes including lymphoid organogenesis, immune cell differentiation, development and positioning. Many chemokines are markedly increased in intestinal tissue from patients with IBD. In this study, we focused on the role of CXCL12-CXCR4 and CXCL16. CXCL12-CXCR4 axis plays a crucial role in the pathophysiology of IBD, especially UC, while SR-PSOX/CXCL16 plays a significant role in the pathophysiology of CD. Our present data suggest new insights into the etiology of IBD and we hope that the manipulation of these chemokines may have therapeutic value. (Intest Res 2012;10:125-133)

Keywords: Inflammatory Bowel Diseases; Chemokine; CXCL12-CXCR4 Axis; CXCL16

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