| Efficacy of Infliximab Rescue Therapy in Hospitalized Patients with Steroid-Refractory Ulcerative Colitis: Single Center Experience |
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Jun Hyung Cho, Chang Kyun Lee, Hyo Jong Kim, Jae Jun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang |
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Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea
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| 스테로이드 불응성 궤양성 대장염 입원 환자에서 Infliximab 구조요법의 효과 |
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조준형, 이창균, 김효종, 심재준, 장재영, 동석호, 김병호, 장영운 |
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경희대학교 의학전문대학원 내과학교실 |
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| Abstract |
Background/Aims
In hospitalized patients with acute steroid-refractory UC, infliximab has been demonstrated to be one of the medical rescue therapies to avoid colectomy. We report the result of a retrospective observational study to find the efficacy and safety of infliximab as a rescue therapy in our hospital. Methods: Between January 2007 and January 2010, 9 hospitalized patients with steroid-refractory UC were selected to receive three infusions of infliximab (5 mg/kg), at weeks 0, 2, and 6. Efficacy of treatment was evaluated at 8 weeks after the first infliximab infusion and at the end of follow-up period. Adverse events related to infliximab rescue therapy were also collected. Results: Seven patients (77.8%) had completed 3 infusions of infliximab and achieved clinical response at 8 weeks after the first infliximab infusion. Clinical remission rate and the rate of mucosal healing at 8 weeks were 57.1% (4/7) and 71.4% (5/7), respectively. They were followed up for median time of 24.9 months (19.5-53.6 months). One patient underwent emergency colectomy at weeks 2, due to colon perforation, while another patient had discontinued infliximab treatment at weeks 4, because of Clostridium difficile-associated colitis. Finally, colectomy was avoided in 77.8% (7/9) of cases. There was no mortality. Conclusions: Rescue therapy with infliximab has sustained clinical benefit in 88.9% of our hospitalized patients with acute steroid-refractory UC. Future prospective and long-term follow-up trials with a large number of patients are needed to confirm the efficacy and safety of the treatment. (Intest Res 2012;10: 0-160) |
| Key Words:
Ulcerative Colitis, Steroid-refractory, Infliximab, Rescue Therapy |
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