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Intest Res > Volume 10(2); 2012 > Article
Intestinal Research 2012;10(2):168-175.
DOI:    Published online April 30, 2012.
Relationship between Positron Emission Tomography Uptake and Macroscopic Findings of Colorectal Cancer
So Young Kim, Sun-Young Lee, Hwa-Kyung Lim, Ji Young Lee, Sung Noh Hong, Jeong Hwan Kim, In Kyung Sung, Hyung Seok Park, Chan Sup Shim, Choon Jo Jin, Hyun Woo Chung2, Young So2
1Departments of Internal Medicine, Statistics
2and Nuclear Medicine, Konkuk University School of Medicine, Seoul, Korea
대장직장암의 육안적 소견에 따른 양전자방출단층촬영 섭취율
김소영, 이선영, 임화경, 이지영, 홍성노, 김정환, 성인경, 박형석, 심찬섭, 진춘조, 정현우2, 소 영2
1건국대학교 의학전문대학원 내과학교실, 통계학과
The semiquantitative parameter "standard uptake value" (SUV) of 18Fluorodeoxyglucose (FDG) positron-emission tomography (PET) provides important additional information about colorectal cancer. In general, colorectal cancers exhibit different growth patterns with different clinicopathological characteristics. The aim of this study was to elucidate the link between the macroscopic appearance of colorectal cancers and maximum SUV (SUVmax) FDG uptakes. Methods: We analyzed 347 patients with colorectal cancer who underwent PET scanning before treatment. The SUVmax of colorectal cancer was analyzed by examining PET images. The macroscopic appearance of each colorectal cancer was classified into three major types: ulcerofungating (n=223), ulceroinfiltrating (n=44), and fungating (n=78). Two cases that were difficult to classify were excluded from the study. Results: The SUVmax was higher in colorectal cancers with an ulcerofungating appearance (12.19±5.84, mean±standard deviation) and ulceroinfiltrating appearance (11.66±5.63) than in those with a fungating appearance (9.58±6.67; P=0.005) (ulcerofungating and ulceroinfiltrative vs. fungating, P<0.001). A smaller tumor size (P<0.001) were significantly related to the fungating colorectal cancer. Four out of six colorectal cancers that did not show FDG uptake were the fungating type. Conclusions: Colorectal cancers with a fungating appearance exhibit a lower SUVmax, shallower invasion and smaller tumor size. Our results indicate that colorectal cancers with a fungating appearance would be less prominent on PET scan than those with an ulcerofungating or ulceroinfiltrating appearance, and thus require more attention. (Intest Res 2012;10: 0-175)
Key Words: Colorectal Neoplasms, Flurodeoxyglucose, Positron Emission Tomography
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