This issue chosen by the Editor of Intestinal Research is “Efficacy of fecal microbiota therapy in steroid dependent ulcerative colitis: a real world intention-to-treat analysis” performed by Ajit Sood, et al. Although available evidence is limited and previous studies have demonstrated variable results, these results suggest that fecal microbiota transplantation (FMT) has the potential as an effective and safe treatment option for UC when standard treatments have failed. This study showed 4-weekly multi-session FMT via colonoscopy could be effective in patients with steroid dependent UC. Steroid free clinical remission (46.3%), clinical response (75.6%) and endoscopic remission (63.4%) were achieved at 24 week, those are better compared with previous studies. In addition to this article, read other articles about FMT in UC Best regards,