Prevalence and risk factors of colorectal cancer in Asia

Martin CS Wong; Hanyue Ding; Jingxuan Wang; Paul SF Chan; Junjie Huang

doi:10.5217/ir.2019.00021

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Review Prevalence and risk factors of colorectal cancer in Asia: Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang; Intestinal Research 2019;17(3):317-329.
DOI: https://doi.org/10.5217/ir.2019.00021
Published online: May 20, 2019

Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

Correspondence to Martin CS Wong, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, 4/F, School of Public Health, Prince of Wales Hospital, Shatin, N.T., Hong Kong Special Administrative Region, China. Tel: +852-2252-8782, Fax: +852-2606-3500, E-mail: wong_martin@cuhk.edu.hk

• Received: March 5, 2019 • Revised: March 29, 2019 • Accepted: April 1, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
INTRODUCTION
PREVALENCE OF CRC
CRC IN ASIA
NON-MODIFIABLE FACTORS
ENVIRONMENTAL RISK FACTORS
DISCUSSION
CONCLUSION
NOTES
Acknowledgments
REFERENCES

Abstract

Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly affecting populations in Asian countries. The overall prevalence of CRC is reported to be low in Asia when compared with that in Western nations, yet it had the highest number of prevalent cases. This review described the prevalence of CRC in Asia according to the International Agency for Research on Cancer from World Health Organization (WHO) database and summarized its major risk factors. Non-modifiable factors include genetic factors, ethnicity, age, gender, family history and body height; smoking, alcohol drinking, weight, Westernized diet, physical inactivity, chronic diseases and microbiota were involved in environmental factors. These risk factors were separately discussed in this review according to published literature from Asian countries. CRC screening has been playing an important role in reducing its disease burden. Some recommendations on its screening practices have been formulated in guidelines for Asia Pacific countries.
Keywords: Colorectal neoplasms; Epidemiology; Risk; Asia

INTRODUCTION

The global burden of colorectal cancer (CRC) has been rising rapidly with population growth, changes in demographics and Westernization of lifestyle habits. It was estimated to have 18.1 million new cancer cases, and 9.6 million deaths caused by cancer in year 2018 [1]. CRC is the third commonest diagnosed cancer and the second leading cause of cancer-related mortality [2,3]. According to the World+Health Organization (WHO) GLOBOCAN database, there are 1,849,518 estimated new CRC cases and 880,792 CRC-related deaths in 2018 [4]. Regional estimates show that among half of the new cases, deaths and 5-year prevalent cases were found in Asia.

Approximately 70% CRC cases are sporadic cases which were influenced by environmental factors including dietary habits, physical activity, smoking and alcohol consumption. About 25% of the CRC cases have a genetic predisposition, and 5% of CRC patients have inherited factors associated with its development [5,6]. Family history of CRC and the presence of common chronic conditions, such as metabolic syndrome and fatty liver, were among the key factors reported by existing literature. In a report from Continuous Update Project [7], being physically active, consuming wholegrains, dairy products, foods containing dietary fiber and taking calcium supplements are protective factors against the risk of CRC [8-11]. On the contrary, consuming red or processed meat, consumption of alcoholic beverages, being overweight or obese, and being tall are the risk factors of CRC [9,11-13]. These factors associated with CRC were supported by a meta-analysis including 103 global cohort studies [14]. Recent studies emphasized that global variations in socio-economic development, dietary habits, lifestyle factors, ethnicity and genetics might be drivers of its diverse epidemiology among different countries. The present review discusses the prevalence of CRC; its risk factors and validated models for risk stratification as developed in various countries.

PREVALENCE OF CRC

The estimated 5-year cancer prevalent cases were shown in Fig. 1. In 2018, there were 4,789,635 patients who had been diagnosed as having CRC within the previous 5 years. CRC affected men and women almost equally, with 2,595,326 men and 2,194,309 women diagnosed with CRC in 2018. The 5-year prevalence of CRC was 62.8/100,000, and ranked the second among all cancer types [4].

The global epidemiological metrics of CRC were shown in Table 1. Europe had the highest 5-year prevalence, incidence and mortality. Although North America had higher prevalence and incidence, the age-standardized mortality rate was similar to that of Asian countries. According to the statistics of the American Cancer Society, it was estimated that approximately 145,600 new CRC cases would be diagnosed in United States for 2019, whereas the mortality rates are decreasing in both men and women in the past decades [15]. More advanced treatment strategies and the implementation of CRC screening might contribute to its mortality decline.

Africa had the lowest 5-year prevalence, crude incidence and crude mortality rates of CRC (Table 1). The incidence and mortality of CRC varied over 10-fold; and the 5-year prevalence varied over 20-fold between Europe and Africa. These regional differences might be due to an interaction between genetic factors and environmental exposure.

CRC IN ASIA

China, Japan, Korea, Malaysia, Singapore and Turkey had higher 5-year prevalence rates than that in other Asian countries (≥ 46.5/100,000) (Fig. 2).

The prevalence, incidence and mortality rates of CRC in Asia were shown in Table 2. China had the highest number of prevalent cases, new cases and deaths, and this could be due to the large population size in China. Japan, Korea, China, Turkey, and Thailand were heavily affected by CRC. India, Indonesia, Vietnam, and Iran had relatively low prevalence, incidence and mortality rates. Tables 1 and 2 showed that certain Asian countries, such as Japan and Korea, the 5-year prevalence and age-standardized incidence were higher than that reported in Western countries. A higher crude incidence (74.1/100,000) and crude mortality (51.5/100,000) was reported for Hong Kong from the latest report of its local Cancer Registry [16]. The temporal trends of these epidemiological figures are different, where China showed an increasing incidence and mortality, Singapore demonstrated rising incidence but reducing mortality, and Japan was reported as having decreasing incidence and mortality [17].

A prospective multinational colonoscopy survey found that more patients were detected as having distal neoplasm than with proximal neoplasm (45.2% vs. 39.3%) [18]. Some literature compared the clinicopathologic characteristics of colorectal adenoma in different timepoint, and suggested a trend of proximization of colorectal adenoma [19,20]. Recently, a Chinese crosssectional study reported a higher adenoma detection rate in the right colon as compared to the left colon (44.1% vs. 39.0%) [21]. This change in tumor-sidedness of colorectal adenoma was similar with global pattern [22]. Comparing Asian and Western countries, the United States had a higher proportion of proximal adenomas than that found in South Korea (62.8% vs. 45.9%, P<0.001) [23]. A Korean study indicated that higher proportion of the older populations had right-sided adenoma than the younger group (76.6% vs. 65.2%, P<0.001) [24]. A study from Japan suggested the gender-specific difference in the proximal shift of CRC, and reported that female gender was an independent factor associated with right-sided adenoma [25]. Since an increasing prevalence of CRC exerts a great impact on public health burden, a targeted approach to identify subjects with risk factors is crucial to inform preventive strategies.

NON-MODIFIABLE FACTORS

There are many risk factors associated with the incidence of CRC. Some non-modifiable factors include genetic factors, ethnicity, age, gender, body height, and family history of CRC.

1. Genetic Factors

The sequential accumulation of mutations in adenomatous polyposis coli (APC), Kirsten-ras (K-ras) and p53 were found to be involved in chromosomal instability (CIN)-associated carcinogenesis, while BAT25 and BAT26 were involved in microsatellite instability (MSI)-associated carcinogenesis [26,27]. However, some Asian studies among patients with CRC showed lower mutation rate of APC, K-ras, and p53 in Mongoloids than Caucasians [28-31]. Novel molecular markers were recently detected by genome-wide association studies (GWAS) in Asia. GWAS has been a powerful tool used to identify variants of single nucleotide polymorphisms (SNP), which could evaluate an individual’s genetic susceptibility to CRC risk. Risk variants were extracted from tumor-adjacent normal tissues, blood samples and buccal cells based on various types of methods to replicate for genotype analysis [32-34]. To date, more than 50 independent loci were identified in relation to their CRC risk. Most GWAS have been conducted among people in European descent [32]. In recent years, researchers had extended their genetic correlation studies to Asian populations, such as Chinese, Japanese and Korean [32, 33, 35, 36]. A study of East-Asian ancestral data introduced 4 loci: 6p21.1 (rs4711689), 8q23.3 (rs2450115, rs6469656), 10q24.3 (rs4919687), and 12p13.3 (rs11064437) which were associated with the risk of CRC [32]. Moreover, personal behavior may also affect the genetic susceptibility and CRC risk. Longer pack-year of cigarette smoking increased CRC risk and significantly interacted with loci of 14q22.3 (rs1957636) and 20p12.3 (rs4813802) in Korean men; 1q41 (rs6687758) and 11q12.2 (rs174537) in Korean women [36]. Besides, Asian and Western ethnicity may have different implications to CRC. Recently, researchers evaluated CRC genetic risk to Asian population and identified 14 loci in the Asia CRC consortium, where 8 loci could not be replicated in European descent [33]. Genetic susceptibility and variation are gaining importance for GWAS and could inform risk of CRC.

2. Ethnicity

The Asia Pacific consensus identified some Asian ethnic groups, like Chinese, Japanese and Korean, that were more susceptible to CRC [37]. A multinational prospective cohort study which included individual of 9 ethnicities (Chinese, Indian, Indonesian, Japanese, Korean, Malay, Filipino, Thai, and white) reported increased risk for advanced colorectal neoplasia among Japanese, Korean and Chinese [18]. One Malaysian study that examined the incidence and mortality by ethnicity reported that Chinese population had the highest age-standardized incidence (27.35/100,000) and age-standardized mortality (11.85/100,000) when compared with Indians and Malays [38]. Similar conclusion was also demonstrated in a Singaporean study that was conducted among populations of Asian Descents, where Chinese had a higher CRC incidence than Indian and Malays [39]. A cohort study of the United States investigated the age-adjusted CRC incidence of Asian populations in California. It found that the incidence among foreign-born Japanese (74.6/100,000) was more than 3-fold of that among foreign-born South Asians (22.0/100,000) [40].

3. Age

Age is the most significant factor influencing the risk of CRC development. Risk of CRC increases dramatically after age 50 years; 90% of all CRCs are diagnosed after 50 years old. According to the Surveillance, Epidemiology and End Results Program from National Cancer Institute, the incidence rate of CRC in the United States increased sharply after age 40 years and rates for male subjects were significantly higher than that in female subjects [41]. This trend was also identified and reported in various Asian countries. One recent Korean report examining the age-specific incidence of CRC reported that the CRC age-specific incidence increased sharply among individuals aged 35 to 64 years when compared with those aged ≥ 65 years [42]. This positive association between CRC risk and advanced age was also reported by the cancer statistics report published for China [43], Japan [44], and Hong Kong [16].

A population-based cluster analysis conducted in China earlier has confirmed that with increasing life expectancy, CRC incidence and mortality are higher [45]. The life expectancy was the highest in Hong Kong (84.23), Japan (83.98), and Korea (82.02) [46]. The longer life expectancy may account for the higher incidence and mortality of CRC in these regions.

4. Gender

Many Asian countries reported that male gender was associated with a higher incidence of CRC. In terms of the latest national estimates of cancer statistics based on the Korea National Cancer Incidence Database, the age-standardized incidence of CRC was higher in male (40.2/100,000) than that in female (22.2/100,000) in 2015 [42]. Others Asian countries or regions also reported similar results, like Japan (64.8/100,000 in male; 36.7/100,000 in female, 2013) [44], China (20.7/100,000 in male; 14.4/100,000 in female, 2014) [43], and Hong Kong (44.6/100,000 in male; 27.6/100,000 in female, 2016) [47]. In addition, there was a differential distribution of CRC between men and women, where higher proportion of men were diagnosed with cancer in the distal rectum and colon than women [48-50]. Although the etiology for gender difference remained uncertain, some researchers made efforts to explain the difference. Some large-scale studies explored the role of estrogens and progestins as protective ingredients against CRC in hormone replacement therapy in postmenopausal women [51,52]. Others suggested that gender difference could be attributed to varying levels of exposure to dietary and lifestyle risk factors [53]. Also, a survey showed that men aged 50 years or above were particularly unaware of the symptoms of CRC and the benefits of screening [54], rendering them less likely to seek medical advice among symptomatic patients and attend screening program among asymptomatic individuals.

5. Family History

People who had a family history of CRC or adenomatous polyps were considered as having higher risk for CRC. Possible explanations included inherited risks, environmental factors, or a combination of both [55]. A case-control study of Hong Kong compared the prevalence of advanced colorectal neoplasia among asymptomatic siblings of CRC patients with siblings of individuals without family members suffering from CRC. The study found a 3-fold difference between the prevalence of advanced neoplasia among case group (7.5%) and control group (2.9%) [56]. Asian studies also supported that family history of CRC was significantly associated with CRC risk (OR, 2.0–3.5) [57,58]. A Korean study further specified family history was associated with proximal colon cancer in men (HR = 1.4) and distal colon cancer in both men (HR = 1.4) and women (HR = 1.6) [59]. A meta-analysis on 9.28 million individuals found that the increase in RR of CRC attributed to family history was higher in younger subjects [60]. Another prospective study conducted in 16 AsiaPacific countries concluded it is unnecessary to discriminate proband identity in screening patients with affected first-degree relatives [61].

6. Body Height

A global meta-analysis reported that each 5-cm increase in height was associated with a RR of 1.04-fold in Western countries [13], and this positive association was also supported by a recent global review [62]. Some Asian research supported this conclusion. A Japanese research found that body height was associated with risk of CRC in both men and women [63]. A Korean study found similar association with risk for colon cancer [64]. Another Korean research indicated height had a positive association with increased risk of distal colon cancer (P-trend = 0.003 in male) and rectal cancer (P-trend = 0.004 in female) [59]. Whereas, other studies reported no significant association between height and CRC risk for either men or women [65,66].

ENVIRONMENTAL RISK FACTORS

1. Smoking

In order to further stratify the risk of CRC, The Asia-Pacific Colorectal Screening Working Group for CRC developed a validated score and identified age, gender, family history and smoking as predictive factors of advanced neoplasia [67]. Smoking is a modifiable risk factor responsible for 8.4% incident CRC and death of CRC in male and 0.4% in female [68]. A Japanese research specifically outlined the positive association between packyears of smoking and the risk of rectal cancer in male [63], while another Singapore-Chinese study reported that smoking was only associated with risk of having rectal cancer [69]. A Korean study also reported that former smokers had higher risk of distal cancer in men (HR = 1.4), but not CRC [59]. Nevertheless, there were 2 studies in Thailand and Oman that reported no significant association between smoking and risk of CRC [70,71].

2. Alcohol Drinking

When compared with non-drinkers, higher alcohol consumption was significantly associated with elevated CRC risk [72,73]. There is a dose-response relationship found in a study from Japan [74], but not among Singaporeans who consumed alcohol 7 or more times per week [69]. Some studies found that the risk of CRC imposed by alcohol consumption affects was different at different sites and in different gender. It has been reported that both frequent and high amount of alcohol consumption had positive associations with the risk of distal colon cancer in Korean men and rectal cancer in Korean women (P-trend < 0.001, respectively) [59]. A study from Japan indicated that alcohol consumption in male demonstrated a dose-response relationship with risk of cancer in distal colon and rectum, but not proximal colon [75]. Drinking alcohol was responsible for higher incidence and mortality of CRC, attributing for 8.7% in men and 1.1% in women in China [68]. Two studies conducted in Thailand [70] and Oman [71] did not show such an association.

3. Overweight and Obesity

A recent cohort study of Asian women observed that obesity has a positive association with risk of colon cancer but not risk of rectal cancer [76]. Whereas, some studies found opposite results that overweight and obesity increased the risk of colon cancer in men only, but not in women [63,65,77-79]. The association between overweight or obesity and CRC risk on both gender was also reported in China [68], Japan [80], Malaysia [72], and Oman [71]. A Korean study found BMI was a site-specific risk factor which was associated with risk of distal colon cancer in men (P-trend < 0.001), and marginally increased risk of proximal colon cancer in women (P-trend = 0.057) [59]. A study conducted in Singapore indicated that there was a U-shaped, quadratic association between BMI and colon cancer risk, but there was no association between BMI and rectal cancer risk [81].

Some studies used other measurements such as waist circumference or waist-hip ratio as a proxy measure of central obesity. The cohort study mentioned before considered abdominal obesity as an independent risk factor for colonic cancer [76]. A Chinese study demonstrated a positive association between central adiposity and CRC risk in male [78]. A systematic review from World Cancer Research Fund and the American Institute for Cancer Research demonstrated RRs were 1.02 per 10 cm increase in waist circumference and 1.03 per 0.1 unit increase in waist-hip ratio [13].

4. Westernized Diet

Westernized diet refers to a dietary composition with more red meat and processed meat, less fruit and vegetable, and it contributes to the development of CRC [82]. There was a systematic review summarizing most associations between dietary patterns and CRC in Asia [83]. This review found that white meats have no association, while red meats and processed meats have positive associations with CRC risk. Conversely, general consumption of vegetables, fruits and fiber are protective factors against CRC risk. This observation was also replicated by recent studies in China [68,84], Korea [85], Japan [58]. Yet, some research reported that the magnitude of the associations were different between gender and sites. For example, a study conducted in Korea indicated there was a higher risk of proximal colon cancer in men (P-trend = 0.005) and rectal cancer in women (P-trend = 0.02) for those who frequently consumed meat [59]. A study performed in Japan concluded that higher consumption of processed meat significantly affected men, not women [86,87]. There are some studies that found no association between food consumption and risk of CRC in China [88], Japan [89,90], and Singapore [91]. The Ohsaki cohort study indicated that a Japanese dietary pattern had no association with CRC risk [92].

5. Physical Inactivity

A systematic review found an inverse association between physical activity and CRC among Japanese population, and this association was stronger for colon cancer than for rectal cancer [93]. A Chinese study found that physical inactivity accounted for 8.9% of all incidence and death of CRC in male and 9.0% in female [68]. A study conducted in Malaysia supported that performing regular physical activity could prevent CRC [72], although the finding was not echoed by a study among Chinese individuals [89].

6. Chronic Diseases

Since aging is global issue, there is a need for us to explore the relationship between multimorbidity and CRC. Generally speaking, common chronic diseases that have been identified as risk factors for CRC include diabetes mellitus, hypertension and coronary artery disease. Individuals with diabetes had higher risk for CRC in China (OR = 4.97) [57]. Diabetes mellitus and hypertension had association with risk of CRC among men but not among women in Korea [79], and similarly in people living in Western countries [90]. Researchers in Hong Kong also reported the prevalence of CRC was higher in patients with coronary artery disease, which might be due to the concomitant presence of diabetes and hypertension among those with heart diseases [94].

7. Microbiota

The influence of microbiota on CRC remains controversial. Recent metagenomics studies suggested a causal relationship between microbial dysbiosis and CRC [95-97]. A study conducted in Hong Kong revealed that the multifaceted role of the microbiome in the development of CRC was indicated by the alterations of the gut virome [98]. There was a support to the bacterial theory of colorectal carcinogenesis. An association of CRC caused by Streptococcus gallolyticus, Bacteroides fragilis, Fusobacterium nucleatum, Peptostreptococcus species was found in another study performed in Hong Kong [99]. Results of a global meta-analysis showed that there was a 1.4-fold increased risk of CRC in patients with Helicobacter pylori, but the authors also admitted that there was a possibility of publication bias which could not be ruled out [100]. Despite the above positive results on the association between microbiota and CRC, inconsistent result was also found. In a meta-analysis based on Asian populations consisting of 2,081 patients with colorectal neoplasm and 5,598 healthy controls, no statistical association between H. pylori infection and risk of colorectal neoplasm was found [101].

DISCUSSION

Stratifying risk tiers of CRC has been recommended by the Asia Pacific Working Group on CRC as a simple means to improve the cost-effectiveness of screening program, as well as to tailor make individuals to receive more appropriate screening tests [102]. To stratify risk among Asians, the most widely-adopted strategy was based on age–asymptomatic individuals aged over 50 years were recommended for screening programs irrespective of their risk. In regions including Korea, Japan, Hong Kong, Singapore, Turkey, and Taiwan, these asymptomatic subjects were subsidized for screening [67,103-105]. Yet in other Asian regions, neither governmental subsidy nor national guidelines were available. Screening colonoscopy studies in Asia confirmed that at the age of 50, the risk of finding advanced neoplasia is significantly increased from around 1% to > 3% [106-109].

However, other factors such as gender, family history, lifestyle habits and race may affect the outcome of CRC screening. Several statistical tools have been developed to stratify the risks of CRC among Asian subjects. Age, body mass index, serum cholesterol, family history of cancer, and alcohol consumption were included in many risk-stratifying models among Korean screening population. Their discriminatory capabilities to stratify risk was moderate, and were noted by studies especially on male subjects [110]. Similarly, Japanese scholars developed risk prediction models by assessing age, BMI, daily physical activity, alcohol consumption, smoking habit, family history of CRC, and diabetes [111]. In addition, China developed its own risk-assessment questionnaire [112]. According to the questionnaire, “high risk” subjects are subsidized to colonoscopy even when their fecal occult blood test results are negative. The Asia-Pacific Colorectal Screening (APCS) developed a validated score ranging from 0 to 7, identifying age, gender, family history and smoking to stratify risk into 3 tiers: 0–1, average risk; 2–3, moderate risk; and 4–7, high risk. subjects with moderate risk and high risk had 2.6-fold (95% CI, 1.1–6.0) and 4.3-fold (95% CI, 1.8–10.3) increased prevalence of advanced neoplasia, respectively, than subjects with average risk [67]. Some guidelines have included the APCS score to stratify subjects according to risk levels–average risk subjects were recommended to receive fecal immunochemical test whilst colonoscopy may be reserved for subjects with high risk [113]. A study compared 4 existing sigmoidoscopy-based strategies, highlighting the need to devise a new scoring system for prediction of advanced proximal neoplasia [114]. A novel instrument of predicting the susceptibility to all colorectal neoplasia in asymptomatic persons has also been developed, facilitating informed choices on screening tools [115]. However, there were some challenges to the adoption of risk algorithms [116], including the time required for stratification in busy clinical settings and the selfreported nature of some variables.

The Asia Pacific Consensus recommended the target age range for CRC screening as 50 to 75 years [102], which is the same as the U.S. Preventive Services Task Force [116]. Meanwhile, as the prevalence of CRC increased sharply among younger Asian adults in the past decades, more scholars noted the importance to develop risk assessment tools, especially for subjects aged < 50 years. Based on the Young Adult Colorectal Screening score in Korea, the risk of advanced colorectal neoplasia increased 5.8-fold (95% CI, 3.4–9.8) in the high-risk tier when compared with the low-risk tier [110]. According to the updated CRC screening guideline from the American Cancer Society, the starting age for CRC screening has been lowered to 45 years old as a qualifying recommendation [117].

More recently, risk stratification tools combining family history and blood-based RNA tests were recommended by international professionals on CRC. Some studies used genetic risk score, which adopts risk variants to predict CRC. Studies in Korea based on 7 SNPs (rs3802842, rs4939827, rs6983267, rs10505477, rs10795668, rs961253, and rs9929218) to develop a genetic risk score for prediction. These 7 SNPs had significant associations with CRC and rectal cancer, but no clear association with colon cancer. To predict CRC, the model that incorporates traditional risk score and genetic risk score failed to show significant change when compared with traditional risk score alone. But for rectal cancer alone, there was a 3% improvement in its discriminatory capability [118]. A Chinese study used 7 SNPs (rs647161, rs10505477, rs6983267, rs10795668, rs7229639, rs4939827, and rs2423279) to build a genetic risk score. The results showed a combination of genetic risk score and traditional risk factors, including age, gender, smoking and alcohol consuming, performed better than traditional risk model to predict CRC risk in Chinese Han population [119]. A study from Japan also reported a significant association between weighted genetic risk score and CRC risk. They also indicated that the prediction model included general risk factors and genetic factors, which was better than models with no genetic components [120].

Adherence is also important to ensure the success of a CRC screening program. Reminders should be considered in individuals with higher risk for CRC screening noncompliance. Recently, a randomized controlled trial showed that telephone calls and short message services conferred a 5.2- and 2.4-fold higher likelihood of compliance [121,122]. More considerations include the affordability of these interventions, and the resources required for post-screening diagnosis [123].

CONCLUSION

CRC is public health burden in Asian countries due to increase in its prevalence and incidence. This should be addressed by health education to heighten disease awareness, formulation of screening initiatives, and strengthening of various preventive strategies. Risk factors in Asia have slight differences with Western countries, and targeted screening based on individual risk seems a cost-effective approach in countries where colonoscopy resources are limited. The development of risk stratification tools for more accurate prediction of CRC and advanced neoplasia is warranted.

NOTES

FINANCIAL SUPPORT

The authors received no financial support for the research, authorship, and/or publication of this article.

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTION

Conceptualization: Wong MC. Writing - original draft preparation: Ding H, Wang J, Chan PS. Writing - review and editing: Ding H, Wang J, Huang J, Wong MC. Supervision project administration: Wong MC. Approval of final manuscript: all authors.

Acknowledgments

Thanks for the cooperation of our team.

Fig. 1.

Estimated 5-year cancer prevalent cases in 2018 (top 10). There were 4,789,635 patients (2,595,326 men and 2,194,309 women) who had been diagnosed as having colorectal cancer within the previous 5 years. Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Fig. 2.

The 5-year prevalence of colorectal cancer in Asia, 2018. China, Japan, Korea, Malaysia, Singapore, and Turkey had higher 5-year prevalence rates than that in others area (≥46.5/100,000). Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Table 1.

Estimated Worldwide Epidemiology of Colorectal Cancer in 2018

Population	5-Year prevalent case	5-Year prevalence^a	New	Crude incidence^a	Age-standardized incidence^a	Death	Crude mortality^a	Age-standardized mortality^a
Asia	2,356,976	51.9^b	957,896	21.1^b	17.7^b	461,422	10.2^b	8.3^b
Europe	1,403,877	188.7^d	499,667	67.2^d	30.0^c	242,483	32.6^d	12.6^c
North America	534,049	146.8^d	179,771	49.4^d	26.2^c	64,121	17.6^c	8.4^b
Latin America and the Caribbean	315,005	48.3^b	128,006	19.6^b	16.8^b	64,666	9.9^b	8.1^b
Africa	113,625	8.8^b	61,846	4.8^b	8.2^b	40,034	3.1^b	5.5^b
Oceania	66,103	160.2^d	22,332	54.1^d	33.1^c	8,066	19.5^c	10.7^c
World	4,789,635	62.8	1,849,518	24.2	19.7	880,792	11.5	8.9

^a Proportions per 100,000.

^b Rate < world proportion.

^c Rate ≥ world proportion & < 2×world proportion.

^d Rate ≥ 2×world proportion.

Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Table 2.

Estimated Epidemiology of Colorectal Cancer in Asia, 2018

Population	5-Year prevalent case	5-Year prevalence^a	New case	Crude incidence^a	Age-standardized incidence^a	Death	Crude mortality^a	Age-standardized mortality^a
China	1,248,644	87.7^c	521,490	36.6^c	23.7^c	247,563	17.4^c	10.9^c
Japan	431,679	339.4^d	148,151	116.5^d	38.9^d	57,910	45.5^d	12.0^c
Korea	122,933	240.3^d	42,363	82.8^d	44.5^d	9,762	19.1^c	8.7^c
India	113,046	8.3^b	56,751	4.2^b	4.4^b	43,090	3.2^b	3.4^b
Indonesia	66,175	24.8^b	30,017	11.3^b	12.1^b	16,386	6.1^b	6.9^b
Turkey	49,614	60.6^c	20,031	24.5^c	21.0^c	10,033	12.2^c	10.2^c
Thailand	42,417	61.3^c	17,534	25.3^c	15.5^b	9,462	13.7^c	8.4^c
Philippines	34,268	32.2^b	15,680	14.7^b	18.9^c	8,821	8.3^b	11.0^c
Vietnam	32,895	34.1^b	14,733	15.3^b	13.4^b	8,104	8.4^b	7.0^b
Iran	24,345	29.7^b	9,864	12.0^b	12.9^b	4,153	5.1^b	5.6^b
Asia	2,356,976	51.9	957,896	21.1	17.7	461,422	10.2	8.3

^a Proportions per 100,000.

^b Rate < world proportion.

^c Rate ≥ world proportion & <2×world proportion.

^d Rate ≥ 2×world proportion.

Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

REFERENCES

1. World Health Organization (WHO). Cancer. WHO Web site https://www.who.int/news-room/fact-sheets/detail/cancer. Updated September 12, 2018. Accessed January 21, 2019.
2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424.Article PubMed
3. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7–34.Article PubMed
4. International Agency for Research on Cancer WHO. Cancer today. IARC Web site https://gco.iarc.fr/today/. Accessed January 21, 2019.
5. Jasperson KW, Tuohy TM, Neklason DW, Burt RW. Hereditary and familial colon cancer. Gastroenterology 2010;138:2044–2058.Article PubMed PMC
6. Migliore L, Migheli F, Spisni R, Coppedè F. Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol 2011;2011:792362.Article PubMed PMC PDF
7. World Cancer Research Fund International. Diet, nutrition, physical activity and cancer https://www.wcrf.org/sites/default/files/Summary-third-expert-report.pdf. Accessed May 10, 2019.
8. Aune D, Chan DS, Lau R, et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ 2011;343:d6617.Article PubMed PMC
9. Perera PS, Thompson RL, Wiseman MJ. Recent evidence for colorectal cancer prevention through healthy food, nutrition, and physical activity: implications for recommendations. Curr Nutr Rep 2012;1:44–54.Article PDF
10. Aune D, Lau R, Chan DS, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol 2012;23:37–45.Article PubMed PDF
11. Vieira AR, Abar L, Chan DS, et al. Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRFAICR Continuous Update Project. Ann Oncol 2017;28:1788–1802.Article PubMed PDF
12. Chan DS, Lau R, Aune D, et al. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One 2011;6:e20456.Article PubMed PMC
13. Abar L, Vieira AR, Aune D, et al. Height and body fatness and colorectal cancer risk: an update of the WCRF-AICR systematic review of published prospective studies. Eur J Nutr 2018;57:1701–1720.Article PubMed PDF
14. Huxley RR, Ansary-Moghaddam A, Clifton P, Czernichow S, Parr CL, Woodward M. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int J Cancer 2009;125:171–180.Article PubMed
15. American Cancer Society. About colorectal cancer. American Cancer Society Web site https://www.cancer.org/content/dam/CRC/PDF/Public/8604.00.pdf. Updated February 21, 2018. Accessed February 13, 2019.
16. Hong Kong Cancer Registry. Overview of Hong Kong cancer statistics of 2016 Hospital Authority Web site. http://www3.ha.org.hk/cancereg/pdf/overview/Summary of CanStat 2016.pdf. Updated October 2018. Accessed February 12, 2019.
17. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017;66:683–691.Article PubMed
18. Byeon JS, Yang SK, Kim TI, et al. Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey. Gastrointest Endosc 2007;65:1015–1022.Article PubMed
19. Nam YJ, Kim KO, Park CS, Lee SH, Jang BI. Clinicopathological features of colorectal polyps in 2002 and 2012. Korean J Intern Med 2019;34:65–71.Article PubMed PDF
20. Kashfi SM, Nazemalhosseini Mojarad E, Pourhoseingholi MA, Asadzadeh Aghdaei H, Anaraki F, Zali MR. Evaluation of the left-to-right shift of colon tumors in Iran: is the trend changing? J Res Med Sci 2015;20:978–986.Article PubMed PMC
21. Zhou H, Shen Z, Zhao J, Zhou Z, Xu Y. Distribution characteristics and risk factors of colorectal adenomas. Zhonghua Wei Chang Wai Ke Za Zhi 2018;21:678–684.PubMed
22. Senore C, Bellisario C, Segnan N. Distribution of colorectal polyps: implications for screening. Best Pract Res Clin Gastroenterol 2017;31:481–488.Article PubMed
23. Cha JM, Kozarek RA, La Selva D, et al. Disparities in prevalence, location, and shape characteristics of colorectal neoplasia between South Korean and U.S. patients. Gastrointest Endosc 2015;82:1080–1086.Article PubMed
24. Lee SY, Song WH, Oh SC, Min BW, Lee SI. Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population. Ann Surg Treat Res 2018;94:36–43.Article PubMed PMC
25. Iida Y, Kawai K, Tsuno NH, et al. Proximal shift of colorectal cancer along with aging. Clin Colorectal Cancer 2014;13:213–218.Article PubMed
26. Jeon CH, Lee HI, Shin IH, Park JW. Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. Int J Colorectal Dis 2008;23:29–35.Article PubMed PDF
27. Jeong SY, Shin KH, Shin JH, et al. Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. Dis Colon Rectum 2003;46:1069–1077.Article PubMed
28. Won YJ, Park KJ, Kwon HJ, et al. Germline mutations of the APC gene in Korean familial adenomatous polyposis patients. J Hum Genet 1999;44:103–108.Article PubMed
29. Hutter P, Rey-Berthod C, Chappuis PO, et al. Molecular and clinical characteristics in 32 families affected with familial adenomatous polyposis. Hum Mutat 2001;18:550.Article
30. Calistri D, Rengucci C, Seymour I, et al. Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression. J Cell Physiol 2005;204:484–488.Article PubMed
31. Oh HE, Cho SJ, Won NH, Lee D, Kim I, Yeom BW. K-ras gene mutations and expression of K-ras, p16, cyclin D1 and p53 in synchronous lesions of the colon adenoma-carcinoma sequences. Korean J Pathol 2001;35:291–298.
32. Zeng C, Matsuda K, Jia WH, et al. Identification of susceptibility loci and genes for colorectal cancer risk. Gastroenterology 2016;150:1633–1645.Article PubMed PMC
33. Lu Y, Kweon SS, Tanikawa C, et al. Large-scale genome-wide association study of East Asians identifies loci associated with risk for colorectal cancer. Gastroenterology 2019;156:1455–1466.Article PubMed
34. Wang N, Lu Y, Khankari NK, et al. Evaluation of genetic variants in association with colorectal cancer risk and survival in Asians. Int J Cancer 2017;141:1130–1139.Article PubMed PMC
35. Abe M, Ito H, Oze I, Nomura M, Ogawa Y, Matsuo K. The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese. J Cancer Res Clin Oncol 2017;143:2481–2492.Article PubMed PMC PDF
36. Song N, Shin A, Jung HS, Oh JH, Kim J. Effects of interactions between common genetic variants and smoking on colorectal cancer. BMC Cancer 2017;17:869.Article PubMed PMC PDF
37. Sung JJ, Lau JY, Young GP, et al. Asia Pacific consensus recommendations for colorectal cancer screening. Gut 2008;57:1166–1176.Article PubMed
38. Abu Hassan MR, Ismail I, Mohd Suan MA, et al. Incidence and mortality rates of colorectal cancer in Malaysia. Epidemiol Health 2016;38:e2016007.Article PubMed PMC PDF
39. Lee HP, Lee J, Shanmugaratnam K. Trends and ethnic variation in incidence and mortality from cancers of the colon and rectum in Singapore, 1968 to 1982. Ann Acad Med Singapore 1987;16:397–401.
40. Ladabaum U, Clarke CA, Press DJ, et al. Colorectal cancer incidence in Asian populations in California: effect of nativity and neighborhood-level factors. Am J Gastroenterol 2014;109:579–588.Article PubMed PMC PDF
41. Noone AM, Howlader N, Krapcho M, et al. SEER cancer statistics review (CSR) 1975-2015 National Cancer Institute Web site. https://seer.cancer.gov/csr/1975_2015/. Updated September 10, 2018. Accessed February 11, 2019.
42. Jung KW, Won YJ, Kong HJ, Lee ES, Community of Population-Based Regional Cancer Registries. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2015. Cancer Res Treat 2018;50:303–316.Article PubMed PMC PDF
43. Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res 2018;30:1–12.Article PubMed PMC
44. Cancer Information Service; National Cancer Center Japan. National estimates of cancer incidence based on cancer registries in Japan (1975-2013) Cancer Information Service Web site. https://ganjoho.jp/en/professional/statistics/table_download.html. Accessed February 13, 2019.
45. Gu X, Zheng R, Xia C, et al. Interactions between life expectancy and the incidence and mortality rates of cancer in China: a population-based cluster analysis. Cancer Commun (Lond) 2018;38:44.Article PubMed PMC PDF
46. The World Bank. Life expectancy at birth, total (years) The World Bank Web site. The World Bank Web site. https://data.worldbank.org/indicator/SP.DYN.LE00.IN?locations=Z4&view=map&year_high_desc=true. Accessed February 14, 2019.
47. Hong Kong Cancer Registry HA. Colorectal cancer in 2016 Hospital Authority Web site. http://www3.ha.org.hk/cancereg/pdf/factsheet/2016/colorectum_2016.pdf. Accessed February 13, 2019.
48. Stewart RJ, Stewart AW, Turnbull PR, Isbister WH. Sex differences in subsite incidence of large-bowel cancer. Dis Colon Rectum 1983;26:658–660.Article PubMed PMC
49. Bonithon-Kopp C, Benhamiche AM. Are there several colorectal cancers? Epidemiological data. Eur J Cancer Prev 1999;8 Suppl 1:S3–S12.Article PubMed
50. McCashland TM, Brand R, Lyden E, de Garmo P, CORI Research Project. Gender differences in colorectal polyps and tumors. Am J Gastroenterol 2001;96:882–886.Article PubMed
51. Newcomb PA, Zheng Y, Chia VM, et al. Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women. Cancer Res 2007;67:7534–7539.Article PubMed
52. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333.Article PubMed
53. Nguyen SP, Bent S, Chen YH, Terdiman JP. Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2009;7:676–681.Article PubMed
54. Sung JJ, Lau JY, Goh KL, Leung WK, Asia Pacific Working Group on Colorectal Cancer.. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 2005;6:871–876.Article PubMed
55. Haggar FA, Boushey RP. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009;22:191–197.Article PubMed PMC PDF
56. Ng SC, Lau JY, Chan FK, et al. Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer. Gastroenterology 2013;144:544–550.Article PubMed
57. Liu Y, Ding WB, Yan C, Bao H, Li K, Wang C. Risk factors of colorectal cancer and its clinical epidemiological study. Biomed Res 2017;28:9871–9874.
58. Kotake K, Koyama Y, Nasu J, Fukutomi T, Yamaguchi N. Relation of family history of cancer and environmental factors to the risk of colorectal cancer: a case-control study. Jpn J Clin Oncol 1995;25:195–202.PubMed
59. Shin A, Joo J, Bak J, et al. Site-specific risk factors for colorectal cancer in a Korean population. PLoS One 2011;6:e23196.Article PubMed PMC
60. Wong MCS, Chan CH, Lin J, et al. Lower relative contribution of positive family history to colorectal cancer risk with increasing age: a systematic review and meta-analysis of 9.28 million individuals. Am J Gastroenterol 2018;113:1819–1827.Article PubMed PMC PDF
61. Wong MC, Ching JY, Chiu HM, et al. Risk of colorectal neoplasia in individuals with self-reported family history: a prospective colonoscopy study from 16 Asia-Pacific regions. Am J Gastroenterol 2016;111:1621–1629.Article PubMed PDF
62. Song X, Gong X, Zhang T, Jiang W. Height and risk of colorectal cancer: a meta-analysis. Eur J Cancer Prev 2018;27:521–529.Article PubMed
63. Shimizu N, Nagata C, Shimizu H, et al. Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study. Br J Cancer 2003;88:1038–1043.Article PubMed PMC PDF
64. Sung J, Song YM, Lawlor DA, Smith GD, Ebrahim S. Height and site-specific cancer risk: a cohort study of a Korean adult population. Am J Epidemiol 2009;170:53–64.Article PubMed PDF
65. Otani T, Iwasaki M, Inoue M, Shoichiro Tsugane for the Japan Public Health Center-based Prospective Study Group. Body mass index, body height, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study. Cancer Causes Control 2005;16:839–850.Article PubMed PDF
66. Pyo JH, Hong SN, Min BH, et al. Is height a risk factor for colorectal adenoma? Korean J Intern Med 2016;31:653–659.Article PubMed PDF
67. Yeoh KG, Ho KY, Chiu HM, et al. The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects. Gut 2011;60:1236–1241.Article PubMed
68. Gu MJ, Huang QC, Bao CZ, et al. Attributable causes of colorectal cancer in China. BMC Cancer 2018;18:38.Article PubMed PMC PDF
69. Tsong WH, Koh WP, Yuan JM, Wang R, Sun CL, Yu MC. Cigarettes and alcohol in relation to colorectal cancer: the Singapore Chinese Health Study. Br J Cancer 2007;96:821–827.Article PubMed PMC PDF
70. Poomphakwaen K, Promthet S, Suwanrungruang K, Kamsaard S, Wiangnon S. Risk factors for colorectal cancer in Thailand. Asian Pac J Cancer Prev 2015;16:6105–6109.Article PubMed PDF
71. Mafiana RN, Al Lawati AS, Waly MI, Al Farsi Y, Al Kindi M, Al Moundhri M. Association between dietary and lifestyle indices and colorectal cancer in Oman: a case-control study. Asian Pac J Cancer Prev 2018;19:3117–3122.Article PubMed PMC PDF
72. Naing C, Lai PK, Mak JW. Immediately modifiable risk factors attributable to colorectal cancer in Malaysia. BMC Public Health 2017;17:637.Article PubMed PMC PDF
73. Choi YJ, Lee DH, Han KD, et al. The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: a nationwide population-based cohort study of South Korea. PLoS One 2017;12:e0185778.Article PubMed PMC
74. Mizoue T, Inoue M, Wakai K, et al. Alcohol drinking and colorectal cancer in Japanese: a pooled analysis of results from five cohort studies. Am J Epidemiol 2008;167:1397–1406.Article PubMed PDF
75. Akhter M, Kuriyama S, Nakaya N, et al. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. Eur J Cancer 2007;43:383–390.Article PubMed
76. Wong TS, Chay WY, Tan MH, Chow KY, Lim WY. Reproductive factors, obesity and risk of colorectal cancer in a cohort of Asian women. Cancer Epidemiol 2019;58:33–43.Article PubMed
77. Guo L, Li N, Wang G, et al. Body mass index and cancer incidence: a prospective cohort study in northern China. Zhonghua Liu Xing Bing Xue Za Zhi 2014;35:231–236.PubMed
78. Li H, Yang G, Xiang YB, et al. Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134255 Chinese men and women. Int J Obes (Lond) 2013;37:783–789.Article PubMed PMC PDF
79. Shin CM, Han K, Lee DH, et al. Association among obesity, metabolic health, and the risk for colorectal cancer in the general population in Korea using the national health insurance service-national sample cohort. Dis Colon Rectum 2017;60:1192–1200.Article PubMed
80. Matsuo K, Mizoue T, Tanaka K, et al. Association between body mass index and the colorectal cancer risk in Japan: pooled analysis of population-based cohort studies in Japan. Ann Oncol 2012;23:479–490.Article PubMed PDF
81. Odegaard AO, Koh WP, Yu MC, Yuan JM. Body mass index and risk of colorectal cancer in Chinese Singaporeans: the Singapore Chinese Health Study. Cancer 2011;117:3841–3849.Article PubMed PMC
82. Yee YK, Tan VP, Chan P, Hung IF, Pang R, Wong BC. Epidemiology of colorectal cancer in Asia. J Gastroenterol Hepatol 2009;24:1810–1816.Article PubMed
83. Azeem S, Gillani SW, Siddiqui A, Jandrajupalli SB, Poh V, Syed Sulaiman SA. Diet and colorectal cancer risk in Asia: a systematic review. Asian Pac J Cancer Prev 2015;16:5389–5396.Article PubMed PDF
84. Chiu BC, Ji BT, Dai Q, et al. Dietary factors and risk of colon cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2003;12:201–208.PubMed
85. Park Y, Lee J, Oh JH, Shin A, Kim J. Dietary patterns and colorectal cancer risk in a Korean population: a case-control study. Medicine (Baltimore) 2016;95:e3759.Article PubMed PMC
86. Oba S, Shimizu N, Nagata C, et al. The relationship between the consumption of meat, fat, and coffee and the risk of colon cancer: a prospective study in Japan. Cancer Lett 2006;244:260–267.Article PubMed
87. Wada K, Oba S, Tsuji M, et al. Meat consumption and colorectal cancer risk in Japan: the Takayama study. Cancer Sci 2017;108:1065–1070.Article PubMed PMC
88. Shin A, Li H, Shu XO, Yang G, Gao YT, Zheng W. Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: results from the Shanghai Women’s Health Study. Int J Cancer 2006;119:2938–2942.Article PubMed
89. Sato Y, Nakaya N, Kuriyama S, Nishino Y, Tsubono Y, Tsuji I. Meat consumption and risk of colorectal cancer in Japan: the Miyagi Cohort Study. Eur J Cancer Prev 2006;15:211–218.Article PubMed
90. Otani T, Iwasaki M, Ishihara J, et al. Dietary fiber intake and subsequent risk of colorectal cancer: the Japan Public Health Center-based prospective study. Int J Cancer 2006;119:1475–1480.Article PubMed
91. Butler LM, Wang R, Koh WP, Yu MC. Prospective study of dietary patterns and colorectal cancer among Singapore Chinese. Br J Cancer 2008;99:1511–1516.Article PubMed PMC PDF
92. Kumagai Y, Chou WT, Tomata Y, et al. Dietary patterns and colorectal cancer risk in Japan: the Ohsaki Cohort Study. Cancer Causes Control 2014;25:727–736.Article PubMed PDF
93. Pham NM, Mizoue T, Tanaka K, et al. Physical activity and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol 2012;42:2–13.Article PubMed PDF
94. Chan AO, Jim MH, Lam KF, et al. Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease. JAMA 2007;298:1412–1419.Article PubMed
95. Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One 2011;6:e16393.Article PubMed PMC
96. Yu J, Feng Q, Wong SH, et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 2017;66:70–78.Article PubMed
97. Zeller G, Tap J, Voigt AY, et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol 2014;10:766.Article PubMed PMC
98. Nakatsu G, Zhou H, Wu WK, et al. Alterations in enteric virome are associated with colorectal cancer and survival outcomes. Gastroenterology 2018;155:529–541.Article PubMed
99. Kwong TN, Wang X, Nakatsu G, et al. Association between bacteremia from specific microbes and subsequent diagnosis of colorectal cancer. Gastroenterology 2018;155:383–390.Article PubMed
100. Zumkeller N, Brenner H, Zwahlen M, Rothenbacher D. Helicobacter pylori infection and colorectal cancer risk: a metaanalysis. Helicobacter 2006;11:75–80.Article PubMed
101. Guo Y, Li HY. Association between Helicobacter pylori infection and colorectal neoplasm risk: a meta-analysis based on East Asian population. J Cancer Res Ther 2014;10 Suppl:263–266.Article PubMed
102. Sung JJ, Ng SC, Chan FK, et al. An updated Asia Pacific consensus recommendations on colorectal cancer screening. Gut 2015;64:121–132.Article PubMed
103. Lee BI, Hong SP, Kim SE, et al. Korean guidelines for colorectal cancer screening and polyp detection. J Korean Soc Radiol 2012;66:385–406.Article
104. Tatar M, Tatar F. Colorectal cancer in Turkey: current situation and challenges for the future. Eur J Health Econ 2010;10 Suppl 1:S99–S105.Article PubMed PDF
105. Ministry of Health Singapore. Screen for life Ministry of Health Singapore Web site. https://www.healthhub.sg/programmes/61/Screen_for_Life. Accessed February 14, 2019.
106. Sung JJ, Chan FK, Leung WK, et al. Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy. Gastroenterology 2003;124:608–614.Article PubMed
107. Choe JW, Chang HS, Yang SK, et al. Screening colonoscopy in asymptomatic average-risk Koreans: analysis in relation to age and sex. J Gastroenterol Hepatol 2007;22:1003–1008.Article PubMed
108. Chiu HM, Wang HP, Lee YC, et al. A prospective study of the frequency and the topographical distribution of colon neoplasia in asymptomatic average-risk Chinese adults as determined by colonoscopic screening. Gastrointest Endosc 2005;61:547–553.Article PubMed
109. Leung WK, Ho KY, Kim WH, et al. Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients. Gastrointest Endosc 2006;64:751–759.Article PubMed PMC
110. Kim JY, Choi S, Park T, et al. Development and validation of a scoring system for advanced colorectal neoplasm in young Korean subjects less than age 50 years. Intest Res 2019;17:253–264.Article PubMed PDF
111. Ma E, Sasazuki S, Iwasaki M, et al. 10-Year risk of colorectal cancer: development and validation of a prediction model in middle-aged Japanese men. Cancer Epidemiol 2010;34:534–541.Article PubMed PMC
112. Meng W, Cai SR, Zhou L, Dong Q, Zheng S, Zhang SZ. Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol 2009;15:6111–6116.Article PubMed PMC
113. Cancer Expert Working Group on Cancer Prevention and Screening (CHP). Prevention and screening for colorectal cancer CHP of Department of Health Web site. https://www.chp.gov.hk/files/pdf/colorectal_ca_en.pdf. Accessed February 14, 2019.
114. Wong MC, Ching JY, Ng SC, et al. Prediction of proximal advanced neoplasia: a comparison of four existing sigmoidoscopy-based strategies in a Chinese population. Gut 2015;64:776–783.Article PubMed PMC
115. Wong MC, Lam TY, Tsoi KK, et al. A validated tool to predict colorectal neoplasia and inform screening choice for asymptomatic subjects. Gut 2014;63:1130–1136.Article PubMed PMC
116. US Preventive Services Task Force; Bibbins-Domingo K, Grossman DC, et al. Screening for colorectal cancer: US preventive services task force recommendation statement. JAMA 2016;315:2564–2575.Article PubMed PMC
117. Wolf AM, Fontham ET, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin 2018;68:250–281.Article PubMed PMC
118. Jung KJ, Won D, Jeon C, et al. A colorectal cancer prediction model using traditional and genetic risk scores in Koreans. BMC Genet 2015;16:49.Article PubMed PMC PDF
119. Li J, Chang J, Zhu Y, et al. Risk prediction of colorectal cancer with common genetic variants and conventional non-genetic factors in a Chinese Han population. Zhonghua Liu Xing Bing Xue Za Zhi 2015;36:1053–1057.PubMed
120. Iwasaki M, Tanaka-Mizuno S, Kuchiba A, et al. Inclusion of a genetic risk score into a validated risk prediction model for colorectal cancer in Japanese men improves performance. Cancer Prev Res (Phila) 2017;10:535–541.Article PubMed PMC
121. Wong MC, Ching JY, Lam TY, et al. Association of interactive reminders and automated messages with persistent adherence to colorectal cancer screening: a randomized clinical trial. JAMA Oncol 2017;3:1281–1283.Article PubMed PMC
122. Wong MC, Ching JY, Huang J, et al. Effectiveness of reminder strategies on cancer screening adherence: a randomised controlled trial. Br J Gen Pract 2018;68:e604–e611.Article PubMed PMC
123. Wong MC. Colorectal cancer screening in Hong Kong: investment of more resources needed to strengthen screening services and inform governmental policy. Hong Kong Med J 2011;17:348–349.PubMed

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Mehran Molavand, Majid Montazer, Somayyeh Ghareghomi, Bahman Yousefi, Maryam Majidinia
Expert Review of Anticancer Therapy.2025; 25(8): 915. CrossRef
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Yue Hu, Wai Man Lau, Zixin Johnson Wang, Raymond Shing Yan Tang, Xixin Wu, Phoenix Kit Han Mo, Samuel Yeung Shan Wong, Mei Ling Helen Meng, Dong Dong, Joseph Jao You Sung, Thomas Yuen Tung Lam
BMJ Open.2025; 15(7): e103857. CrossRef
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Seyed Ehsan Mousavi, Mehran Ilaghi, Romina Hamidi Rad, Seyed Aria Nejadghaderi
Scientific Reports.2025;[Epub] CrossRef
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Husam H. Hasan
Medical Journal of Babylon.2025; 22(Suppl 1): S37. CrossRef
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Sima Shirmohammadzadeh, Aghil Tabar Molla Hasan, Amirreza Abedi Masir, Fatereh Rezaei
Journal of Health Reports and Technology.2025;[Epub] CrossRef
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Nanxi Zhao, Hao Chen, Shuang Cai, Qu Li, Jianfeng Wang, Wei Wang, Chengzhou Lv
Industrial Crops and Products.2025; 235: 121608. CrossRef
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Aminah G. Alotaibi, Bashayer A. Alfozan, Sara S. Alotaibi, Amal S. Al Mutairi, Aisha Y. Al Humoudi, Nora A. Al Jawini, Adel H. Alshehri, Hussah N. Albahlal, Sahar S. Alghamdi
Pathology - Research and Practice.2025; 275: 156206. CrossRef
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Hyobin Lee, Linda Ngoun, Sukhong Min, Jialei Fu, Woo-Kyoung Shin, Daehee Kang, Sangah Shin
Cancer Causes & Control.2025;[Epub] CrossRef
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Research Journal of Pharmacy and Technology.2025; : 4527. CrossRef
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International Journal of Molecular Sciences.2025; 26(17): 8297. CrossRef
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Jung Hyun Ji, Hyun Woo Kim, Jihye Park, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Jae Jun Park
Surgical Endoscopy.2024; 38(2): 846. CrossRef
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Ga Hee Kim, Yeong Chan Lee, Tae Jun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Dong-Hoon Yang, Chang Mo Moon, Kyunga Kim, Hyun Gun Kim, Eun-Ran Kim
World Journal of Gastrointestinal Oncology.2024; 16(1): 51. CrossRef
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Ming Yan Pun, Pak Ho Leung, Tsz Ching Chan, Chunn Pang, Kin Hei Chan, Priya Kannan
Supportive Care in Cancer.2024;[Epub] CrossRef
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Michelle Nagata, Kohei Miyagi, Brenda Y. Hernandez, Scott K. Kuwada
Cancers.2024; 16(2): 398. CrossRef
Cancer screening programs in South-east Asia and Western Pacific
Hwee-Lin Wee, Karen Canfell, Han-Mo Chiu, Kui Son Choi, Brian Cox, Nirmala Bhoo-Pathy, Kate T Simms, Chisato Hamashima, Qianyu Shen, Brandon Chua, Niyomsri Siwaporn, Esther Toes-Zoutendijk
BMC Health Services Research.2024;[Epub] CrossRef
RETRACTED: Comparison of prediction fuzzy modeling towards high-risk symptoms of lung cancer
Aliya Syaffa Zakaria, Muhammad Ammar Shafi, Mohd Arif Mohd Zim, Aisya Natasya Musa
Journal of Intelligent & Fuzzy Systems.2024; 46(4): 7959. CrossRef
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Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Current Developments in Nutrition.2024; 8(3): 102127. CrossRef
Health-related quality of life and related factors in patients with colorectal cancer in Iran: a systematic review
Zahra Naeimabadi, Homayoon Bana Derakhshan, Maryam Rassouli, Abbas Ebadi
Annals of Medicine & Surgery.2024; 86(4): 2088. CrossRef
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Antony Nguyen, Filmer Yu, Linda G. Park, Yoshimi Fukuoka, Ching Wong, Ginny Gildengorin, Tung T. Nguyen, Janice Y. Tsoh, Jane Jih
JMIR Formative Research.2024;[Epub] CrossRef
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Zahra Shokati Eshkiki, Fatemeh Mansouri, Amir Reza Karamzadeh, Abolfazl Namazi, Hafez Heydari, Javad Akhtari, Seidamir Pasha Tabaeian, Abolfazl Akbari, Hongda Liu
Journal of Clinical Pharmacy and Therapeutics.2024;[Epub] CrossRef
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Claudia Santucci, Silvia Mignozzi, Fabio Levi, Matteo Malvezzi, Paola Bertuccio, Anna Odone, M. Constanza Camargo, Carlo La Vecchia, Eva Negri
European Journal of Cancer Prevention.2024; 33(6): 493. CrossRef
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I Ketut Mariadi, Ni Nyoman Metriani Nesa, Gde Somayana, Kurniawan Kurniawan
Research Journal of Pharmacy and Technology.2024; : 1050. CrossRef
Oxidative Stress Assessment in Colorectal Cancer Patients
Vyan A. Qadir, Kamaran K. Abdoulrahman
ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY.2024; 12(1): 115. CrossRef
Risk prediction of advanced colorectal neoplasia among diabetic patients: A derivation and validation study
Martin CS Wong, Sarah Tsz Yui Yau, Eman YM Leung, Harry HX Wang, Junjie Huang
JGH Open.2024;[Epub] CrossRef
Prediction of Lymph Node Metastasis in T1 Colorectal Cancer Using Artificial Intelligence with Hematoxylin and Eosin-Stained Whole-Slide-Images of Endoscopic and Surgical Resection Specimens
Joo Hye Song, Eun Ran Kim, Yiyu Hong, Insuk Sohn, Soomin Ahn, Seok-Hyung Kim, Kee-Taek Jang
Cancers.2024; 16(10): 1900. CrossRef
Molecular epidemiology, antibiotic resistance profile and frequency of integron 1 and 2 in adherent-invasive Escherichia coli isolates of colorectal cancer patients
Aida Heidari, Mohammad Hassan Emami, Fatemeh Maghool, Samane Mohammadzadeh, Parisa Kadkhodaei Elyaderani, Tahereh Safari, Alireza Fahim, Razie Kamali Dolatabadi
Frontiers in Microbiology.2024;[Epub] CrossRef
The association between neighborhood socioeconomic status and the risk of incidence and mortality of colorectal cancer: A systematic review and meta-analysis of 1,678,582 participants
Faramarz Jalili, Mohammad Hajizadeh, Sanaz Mehrabani, Seyed Mojtaba Ghoreishy, Felicity MacIsaac
Cancer Epidemiology.2024; 91: 102598. CrossRef
Gut microbiota characteristics of colorectal cancer patients in Hubei, China, and differences with cohorts from other Chinese regions
Jianguo Shi, Hexiao Shen, Hui Huang, Lifang Zhan, Wei Chen, Zhuohui Zhou, Yongling Lv, Kai Xiong, Zhiwei Jiang, Qiyi Chen, Lei Liu
Frontiers in Microbiology.2024;[Epub] CrossRef
The inhibitory effects of the novel Lactobacillus cocktail on colorectal cancer development through modulating BMP signaling pathway: In vitro and in vivo Study
Amin Sepehr, Shadi Aghamohammad, Roya Ghanavati, Ali Karimi Bavandpour, Malihe Talebi, Mahdi Rohani, Mohammad Reza Pourshafie
Heliyon.2024; : e36554. CrossRef
Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer
Wen-Xuan Fan, Fei Su, Yan Zhang, Xiao-Ling Zhang, Yun-Yi Du, Yang-Jun Gao, Wei-Ling Li, Wen-Qing Hu, Jun Zhao
Biomarker Research.2024;[Epub] CrossRef
A higher dietary alpha-linolenic acid intake is associated with lower colorectal cancer risk based on MUC4 rs2246901 variant among Korean adults
Ha Thi Mien Nguyen, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Nutrition Research.2024; 131: 71. CrossRef
Biofilm mediated integrin activation and directing acceleration of colorectal cancer
Vaijayanthi Saravanan, Vinoj Gopalakrishnan, Maria Infant Majula Shifani Mahendran, Rajan Vaithianathan, Sowmya Srinivasan, Vinoth Boopathy, SriKrishna Krishnamurthy
APMIS.2024; 132(10): 688. CrossRef
Impact of a Health Promotion Program on Knowledge, Physical Health, Mental Health, and Social Health Behaviors in Individuals at Risk for Colorectal Cancer
Surachet Fakkiew, Supat Teravecharoenchai, Panit Khemtong, Wanich Suksatan
Societies.2024; 14(9): 182. CrossRef
S100A4 contributes to colorectal carcinoma aggressive behavior and to chemoradiotherapy resistance in locally advanced rectal carcinoma
Yohei Harada, Sayako Ikeda, Yuna Kawabe, Yasuko Oguri, Miki Hashimura, Ako Yokoi, Akiko Sida, Naomi Fukagawa, Misato Hayashi, Mototsugu Ono, Chika Kusano, Hiroyuki Takahashi, Makoto Saegusa
Scientific Reports.2024;[Epub] CrossRef
ERAS implementation for colorectal cancers at Da Nang Oncology Hospital
Xuân Thạch Cao
Vietnam Journal of Endolaparoscopic Surgey.2024;[Epub] CrossRef
Self-care knowledge in patients with intestinal stomas in a selected hospital in the south of Viet Nam: A descriptive cross-sectional study
Thi Dung Ngo, Miranda Hawks, Thi Thanh Truc Nguyen, Thi Ngoc Han Nguyen, Hong Thiep Nguyen, Nguyen Thanh Truc Mai
Belitung Nursing Journal.2023; 9(4): 331. CrossRef
Assessment of the Anticancer Potentials of the Free and Metal-Organic Framework (UiO-66) – Delivered Phycocyanobilin
Suzan A. Rashed, Sherif F. Hammad, Moustafa M. Eldakak, Islam A. Khalil, Ahmed Osman
Journal of Pharmaceutical Sciences.2023; 112(1): 213. CrossRef
Analysis of the gut microbiome using extracellular vesicles in the urine of patients with colorectal cancer
Hyuk Yoon, Nam-Eun Kim, Jihye Park, Cheol Min Shin, Nayoung Kim, Dong Ho Lee, Jae Yong Park, Chang Hwan Choi, Jae Gyu Kim, Young Soo Park
The Korean Journal of Internal Medicine.2023; 38(1): 27. CrossRef
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Sanpagavalli Doraimuthu, Maznah Dahlui, Victor Chee Wai Hoe, Tin Tin Su
Asia Pacific Journal of Public Health.2023; 35(1): 27. CrossRef
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Nileema R. Divate, Katharina Ardanareswari, Yu-Ping Yu, Ya-Chen Chen, Jiunn-Wang Liao, Yun-Chin Chung
Processes.2023; 11(1): 257. CrossRef
Research Progress of Intestinal Microecology in the Pathogenesis of Colorectal Adenoma and Carcinogenesis
Zhipeng Zhang, Nisma Lena Bahaji Azami, Ningning Liu, Mingyu Sun
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies
Samhita De, Sourav Paul, Anirban Manna, Chirantan Majumder, Koustav Pal, Nicolette Casarcia, Arijit Mondal, Sabyasachi Banerjee, Vinod Kumar Nelson, Suvranil Ghosh, Joyita Hazra, Ashish Bhattacharjee, Subhash Chandra Mandal, Mahadeb Pal, Anupam Bishayee
Cancers.2023; 15(3): 993. CrossRef
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Journal of Personalized Medicine.2023; 13(4): 576. CrossRef
Cinnamic acid derivatives as potential matrix metalloproteinase-9 inhibitors: molecular docking and dynamics simulations
Mohammad Hossein Malekipour, Farzaneh Shirani, Shadi Moradi, Amir Taherkhani
Genomics & Informatics.2023; 21(1): e9. CrossRef
Insights on the Biomarker Potential of Exosomal Non-Coding RNAs in Colorectal Cancer: An In Silico Characterization of Related Exosomal lncRNA/circRNA–miRNA–Target Axis
Maria Mezher, Samira Abdallah, Ohanes Ashekyan, Ayman Al Shoukari, Hayat Choubassy, Abdallah Kurdi, Sally Temraz, Rihab Nasr
Cells.2023; 12(7): 1081. CrossRef
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M. Mojally, R. Abdou, W. Bokhari, S. Sab, M. Dawoud, A. Albohy
Brazilian Journal of Medical and Biological Research.2023;[Epub] CrossRef
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Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keit
Scientific Reports.2023;[Epub] CrossRef
Recent Progress and Perspective of an Evolving Carbon Family From 0D to 3D: Synthesis, Biomedical Applications, and Potential Challenges
Wenhui Yi, Asif Khalid, Naila Arshad, M. Sohail Asghar, Muhammad Sultan Irshad, Xianbao Wang, Yueyang Yi, Jinhai Si, Xun Hou, Hong Rong Li
ACS Applied Bio Materials.2023; 6(6): 2043. CrossRef
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Carissa Ikka Pardamean, Digdo Sudigyo, Arif Budiarto, Bharuno Mahesworo, Alam Ahmad Hidayat, James W. Baurley, Bens Pardamean
Oncology Reviews.2023;[Epub] CrossRef
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer
T. Yoshino, A. Cervantes, H. Bando, E. Martinelli, E. Oki, R.-H. Xu, N.A. Mulansari, K. Govind Babu, M.A. Lee, C.K. Tan, G. Cornelio, D.Q. Chong, L.-T. Chen, S. Tanasanvimon, N. Prasongsook, K.-H. Yeh, C. Chua, M.D. Sacdalan, W.J. Sow (Jenson), S.T. Kim,
ESMO Open.2023; 8(3): 101558. CrossRef
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Hadi Feizi, Mohammad Ahangarzadeh Rezaee, Reza Ghotaslou, Mohammad Sadrkabir, Farhad Jadidi-Niaragh, Pourya Gholizadeh, Sepehr Taghizadeh, Khudaverdi Ghanbarov, Mehdi Yousefi, Hossein Samadi Kafil
Current Pharmaceutical Biotechnology.2023; 24(8): 1018. CrossRef
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Fatemeh Ghasemi-Kebria, Nastaran Jafari-Delouie, Shahryar Semnani, Abdolreza Fazel, Arash Etemadi, Alireza Norouzi, Reza Khandoozi, Sima Besharat, Nesa Shokouhifar, Honyehsadat Mirkarimi, SeyyedMehdi Sedaghat, Mohsen Mansoury, Mahshid Mehrjerdian, Elisabe
Cancer Epidemiology.2023; 86: 102415. CrossRef
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Shiori Nakano, Taiki Yamaji, Kouya Shiraishi, Akihisa Hidaka, Taichi Shimazu, Aya Kuchiba, Masahiro Saito, Fumihito Kunishima, Ryouji Nakaza, Takashi Kohno, Norie Sawada, Manami Inoue, Shoichiro Tsugane, Motoki Iwasaki
Carcinogenesis.2023; 44(6): 476. CrossRef
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Hyejung Kang, Chung Mo Nam, Dong-Woo Choi, Sohee Park
Frontiers in Oncology.2023;[Epub] CrossRef
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Marwh Gassim Aldriwesh, Abrar Alnodley, Norah Almutairi, Mohammed Algarni, Ayyob Alqarni, Bayan Albdah, Mutaib Mashraqi
Saudi Journal of Medicine & Medical Sciences.2023; 11(3): 208. CrossRef
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Sidhant Jain, Meenakshi Rana, Pooja Choubey, Sahil Kumar
Acta Parasitologica.2023; 68(4): 723. CrossRef
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Alexandru Isaic, Alexandru Cătălin Motofelea, Dan Costachescu, Gheorghe Nicusor Pop, Bogdan Totolici, Dorel Popovici, Razvan Gheorghe Diaconescu
Healthcare.2023; 11(16): 2347. CrossRef
Ras-Related Protein Rap1A Accelerates the Malignant Process of Colorectal Carcinoma via Activating Fibroblast Growth Factor-2
Xuezhong Liu, Qiuyuan Wang
Journal of Biomedical Nanotechnology.2023; 19(7): 1301. CrossRef
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Mudatsir, Ibrahim Labeda, Julianus Aboyaman Uwuratuw, Joko Hendarto, Warsinggih, Ronald Erasio Lusikooy, Mappincara, Samuel Sampetoding, Muhammad Ihwan Kusuma, Erwin Syarifuddin, Arham Arsyad, Muhammad Faruk
Annals of Medicine & Surgery.2023; 85(9): 4277. CrossRef
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Nafiseh Rahmani, Ghazaleh Pourali, Nayyerehalsadat Hosseini, Hamid Fiuji, Mina Maftooh, Seyed Mahdi Hassanian, Gordon A Ferns, Majid Khazaei, Amir Avan
Current Cancer Drug Targets.2023; 23(10): 764. CrossRef
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Linh Thi Dieu Nguyen, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Journal of Cancer Research and Clinical Oncology.2023; 149(18): 16429. CrossRef
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Hemant Devidas Une, Mrudula Yogesh Kumavat, Amar Bhagwan Shirsat
Indian Journal of Pathology and Oncology.2023; 10(3): 224. CrossRef
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Chenyu Sun, Yue Chen, Shaodi Ma, Mengqing Liu, Vicky Yau, Na Hyun Kim, Sujatha Kailas, Scott Lowe, Rachel Bentley, Shuya Chen, Jie Liu, Muzi Meng, Yuting Huang, Qin Zhou, Yuyan Wu
Journal of Evidence-Based Medicine.2023; 16(3): 332. CrossRef
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Shan Li, Xuguang Sun, Ting Li, Yanqing Shi, Binjie Xu, Yuyong Deng, Sifan Wang
BMC Medical Genomics.2023;[Epub] CrossRef
Implications of single-cell immune landscape of tumor microenvironment for the colorectal cancer diagnostics and therapy
Ahmad Alzamami
Medical Oncology.2023;[Epub] CrossRef
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Zainab Shateri, Maede Makhtoomi, Fatemeh Mansouri, Milad Rajabzadeh-dehkordi, Mehran Nouri, Bahram Rashidkhani
BMC Nutrition.2023;[Epub] CrossRef
ABO and Rhesus blood group markers as predictors in colorectal cancer: A prospective observational study
Gowhar Rashid, Gulzar A. Bhat, Tahseen Bilal Rather, Kulsum Akhtar, Ishrat Parveiz, Syed Nisar Ahmad, Malik Tariq Rasool, Farooq Ahmad Jan, Mohanad Diab, Wael Hafez, Syed Mudassar
Medicine.2023; 102(47): e36256. CrossRef
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Haytham Bouammali, Linda Zraibi, Imane Ziani, Mohammed Merzouki, Lamiae Bourassi, Elmehdi Fraj, Allal Challioui, Khalil Azzaoui, Rachid Sabbahi, Belkheir Hammouti, Shehdeh Jodeh, Maryam Hassiba, Rachid Touzani
Plants.2023; 13(1): 89. CrossRef
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Cancers.2023; 16(1): 183. CrossRef
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Yongting Lan, Yang Yang, Abhijit Das, Barshana Bhattacharya, Souvik Roy
Indian Journal of Pharmacology.2023; 55(2): 97. CrossRef
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David Bars-Cortina, Ali Sakhawat, Carme Piñol-Felis, María-Jose Motilva
Seminars in Cancer Biology.2022; 81: 241. CrossRef
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Ibtisam Ismail, Huan Keat Chan, Soelar Shahrul Aiman, Abu Hassan Muhammad Radzi
Journal of Cancer Research and Therapeutics.2022; 18(4): 931. CrossRef
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Yoon Suk Jung, Nam Hee Kim, Youngwoo Kim, Dong Il Park
Digestive and Liver Disease.2022; 54(4): 537. CrossRef
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Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
The Korean Journal of Internal Medicine.2022; 37(2): 313. CrossRef
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Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong‐Soo Lee, Hye‐Sook Chang, Hye Won Park, Gwang‐Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong‐Sik Byeon, Seung‐Jae Myung, Suk‐Kyun Yang, Jaewon Choe, Dong‐Hoon Yang
Digestive Endoscopy.2022; 34(4): 850. CrossRef
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Yoon Suk Jung, Eui Im, Chan Hyuk Park
Surgical Endoscopy.2022; 36(6): 4299. CrossRef
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Sung Noh Hong, Chang Kyun Lee, Jong Pil Im, Chang Hwan Choi, Jeong-Sik Byeon, Young-Seok Cho, Sung-Ae Jung, Tae Il Kim, Yoon Tae Jeen
Gastrointestinal Endoscopy.2022; 95(3): 500. CrossRef
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Mehrdad Mohammadi, Hamed Mirzaei, Mitra Motallebi
Anaerobe.2022; 73: 102501. CrossRef
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Min Cheol Kim, Kyeong Ok Kim, Min Kyu Kang
The Korean Journal of Internal Medicine.2022; 37(2): 294. CrossRef
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Ji-Bin Li, Zhi-Yu Qiu, Yu-Xiang Deng, Yin Li, Zhuo-Chen Lin, Yan-Ping Wu, Fan Weng, Huan Tian, Qing-Jian Ou, Cheng-Hua Gong, Zhi-Zhong Pan, De-Sen Wan, Jian-Hong Peng, Yu-Jing Fang
Discover Oncology.2022;[Epub] CrossRef
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Congcong Wang, Xiao Qiao, Jingwen Wang, Jia Yang, Chen Yang, Yi Qiao, Yue Guan, Aidong Wen, Liuqin Jiang
European Journal of Inflammation.2022;[Epub] CrossRef
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Lina Choe, Jerrald Lau, Si-Ying Fong, Emily Chew, Wen-Min Chow, Yan Pang, Tian-Zhi Lim, Choon-Seng Chong, Min-Hoe Chew, Fung-Joon Foo, Frederick Hong-Xiang Koh, Mee-Lian Wong, Gerald Choon-Huat Koh, Ker-Kan Tan
Gastrointestinal Endoscopy.2022; 95(3): 519. CrossRef
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Seung Wook Hong, Seohyun Lee, Yun Jae Kim, Soyeon Ahn, In Ja Park, Seung‐Mo Hong, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Suk‐Kyun Yang, Jaeil Kim, Sang‐Yeob Kim, Seung‐Jae Myung
Journal of Gastroenterology and Hepatology.2022; 37(3): 542. CrossRef
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雅君陈
Hans Journal of Food and Nutrition Science.2022; 11(01): 44. CrossRef
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Qianqian Du, Jingyu Chen, Ya Meng, Ni Gong, Xiaodan Wu, Qiyuan Lyu, Yiheng Zhang, Xiaoyu Wu, Meifen Zhang
Cancer Nursing.2022; 45(2): E447. CrossRef
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Natsumi Takei, Takashi Kuda, Natsumi Handa, Hajime Takahashi, Bon Kimura
Food Bioengineering.2022; 1(1): 91. CrossRef
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Zeynep S. BAHCE, Serdar GUMUS, Ebral YIGIT
Chirurgia.2022;[Epub] CrossRef
Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3–4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis
Suyeon Park, Seong Ran Jeon, Hyun Gun Kim, Yunho Jung, Min-Seob Kwak, Su Young Kim, Jong Wook Kim, Seung-Joo Nam, Eun Hye Oh, Seon-Young Park, Soo-Kyung Park, Jeong-Sik Byeon, Sun-Jin Boo, Dong Hoon Baek, Soon Man Yoon, Jaeyoung Chun, Jooyoung Lee, Miyoun
American Journal of Gastroenterology.2022; 117(4): 588. CrossRef
Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art
Alessia Chini, Michele Manigrasso, Grazia Cantore, Rosa Maione, Marco Milone, Francesco Maione, Giovanni Domenico De Palma
Clinical Endoscopy.2022; 55(2): 183. CrossRef
Meta-Analysis of the Association between Dietary Inflammatory Index (DII) and Colorectal Cancer
Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Mohd Hasni Ja’afar, Zaleha Md Isa, Huan-Keat Chan, Muhammad Radzi Abu Hassan
Nutrients.2022; 14(8): 1555. CrossRef
Report of 13-year survival of patients with colon and rectal cancers; lessons from Shiraz colorectal cancer surgery registry system of a level three medical center
Ali Reza Safarpour, Alimohammad Bananzadeh, Ahmad Izadpanah, Leila Ghahramani, Seyed Mohammad Kazem Tadayon, Faranak Bahrami, Seyed Vahid Hosseini
BMC Surgery.2022;[Epub] CrossRef
Effects of Jianpi Lishi Jiedu granules on colorectal adenoma patients after endoscopic treatment: study protocol for a randomized, double-blinded, placebo-controlled clinical trial
Hao Wu, Yuzhen Huang, Lu Yang, Kunhan Su, Shuo Tian, Xin Chen, Siyu Li, Wanli Liu
Trials.2022;[Epub] CrossRef
Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
Oluwafemi Adeleke Ojo, Temiloluwa Rhoda Adeyemo, Damilare Rotimi, Gaber El-Saber Batiha, Gomaa Mostafa-Hedeab, Matthew Eboseremen Iyobhebhe, Tobiloba Christiana Elebiyo, Bukola Atunwa, Adebola Busola Ojo, Clara Mariana Goncalves Lima, Carlos Adam Conte-Ju
Frontiers in Oncology.2022;[Epub] CrossRef
Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin
Ruting Zhong, Mohamed A. Farag, Meiwan Chen, Chengwei He, Jianbo Xiao
eFood.2022;[Epub] CrossRef
The Influence of Face Shields on the Quality of Colonoscopy in the Era of the COVID-19 Pandemic
Jin Wook Lee, Hyo Jeong Lee, Dae Sung Kim, Jiyoung Yoon, Seung Wook Hong, Ha Won Hwang, Jong-Soo Lee, Gwang-Un Kim, Sinwon Lee, Jaewon Choe, Jin Hwa Park, Dong-Hoon Yang, Jeong-Sik Byeon
Gut and Liver.2022; 16(3): 404. CrossRef
rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis
Refka Jelassi, Sabrine Dhouioui, Hamza Ben Salah, Nasreddine Saidi, Nabiha Mzoughi, Radhia Ammi, Aida Bouratbine, Karim Aoun, Ines Zidi, Hanen Chelbi
Frontiers in Genetics.2022;[Epub] CrossRef
Quality indicators in colonoscopy: the chasm between ideal and reality
Su Bee Park, Jae Myung Cha
Clinical Endoscopy.2022; 55(3): 332. CrossRef
Tumor Detection on Microarray Data Using Grey Wolf Optimization with Gain Information
K. Dhana Sree Devi, P. Karthikeyan, Usha Moorthy, K. Deeba, V. Maheshwari, Shaikh Muhammad Allayear, Shimin Wang
Mathematical Problems in Engineering.2022; 2022: 1. CrossRef
A Systematic Review and Meta‐analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population
Hafeez Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch’ng Ewe Seng, Siti Norasikin Binti Mohd Nafil, Ahmad Aizat Bin Abdul Aziz, Yusuf Wada, Ahmad Irekeola, Syed Sameer Aga
BioMed Research International.2022;[Epub] CrossRef
Title: Involvement of unsaturated fatty acid biosynthesis in CRC progression based on in vitro and in silico studies
Khatere Mokhtari, Mohammad Mahdevar, Maral Hajipour, Maryam Esmaeili, Maryam Peymani, Sepideh Mirzaei, Mohammad Hossein Nasr-Esfahani, Mehrdad Hashemi, Kiavash Hushmandi, Kamran Ghaedi
Biomedicine & Pharmacotherapy.2022; 153: 113338. CrossRef
Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats
Yongjian Liu, Xin Qi
Journal of Oleo Science.2022; 71(7): 1021. CrossRef
Utility of artificial intelligence with deep learning of hematoxylin and eosin-stained whole slide images to predict lymph node metastasis in T1 colorectal cancer using endoscopically resected specimens; prediction of lymph node metastasis in T1 colorecta
Joo Hye Song, Yiyu Hong, Eun Ran Kim, Seok-Hyung Kim, Insuk Sohn
Journal of Gastroenterology.2022; 57(9): 654. CrossRef
Plant-derived bioactive compounds in colon cancer treatment: An updated review
Akanksha Esmeeta, Subhamay Adhikary, V. Dharshnaa, P. Swarnamughi, Z. Ummul Maqsummiya, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Biomedicine & Pharmacotherapy.2022; 153: 113384. CrossRef
Harmol alleviates dimethylhydrazine induced colon cancer by downregulating Bcl2/IL-6/TNF-α expression in association with p53 mediated apoptosis
Ni Guo, Jie Gao
European Journal of Inflammation.2022;[Epub] CrossRef
Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians
Jie Ping, Yaohua Yang, Wanqing Wen, Sun‐Seog Kweon, Koichi Matsuda, Wei‐Hua Jia, Aesun Shin, Yu‐Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong‐Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min‐Ho Shin, Chizu Tanikawa, Zhi‐Zhong Pan, Jae Hwan Oh,
International Journal of Cancer.2022; 151(10): 1726. CrossRef
The emerging era of personalized medicine in advanced colorectal cancer
Claudia W K Wu, Madeleine Reid, Simon Leedham, Rashid N Lui
Journal of Gastroenterology and Hepatology.2022; 37(8): 1411. CrossRef
Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer
Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
Scientific Reports.2022;[Epub] CrossRef
Long-Time Trend of Colorectal Cancer Mortality Attributable to High Processed Meat Intake in China and a Bayesian Projection from 2020 to 2030: A Model-Based Study
Fangyao Chen, Shiyu Chen, Yaqi Luo, Aima Si, Yuhui Yang, Yemian Li, Weiwei Hu, Yuxiang Zhang
International Journal of Environmental Research and Public Health.2022; 19(17): 10603. CrossRef
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
International Journal of Nanomedicine.2022; Volume 17: 3933. CrossRef
Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital
Nur Rahadiani, Muhammad Habiburrahman, Murdani Abdullah, Wifanto Saditya Jeo, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni
BMJ Open.2022; 12(9): e060839. CrossRef
Colorectal cancer in patients with SARS-CoV-2: a systematic review and meta-analysis
Saad Alhumaid, Abbas Al Mutair, Jawad S. Busubaih, Nourah Al Dossary, Murtadha Alsuliman, Sarah A. Baltyour, Ibrahim Alissa, Hassan I. Al Hassar, Noor A. Al Aithan, Hani A. Albassri, Suliman A. AlOmran, Raed M. ALGhazal, Ahmed Busbaih, Nasser A. Alsalem,
Infectious Agents and Cancer.2022;[Epub] CrossRef
Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Journal of Personalized Medicine.2022; 12(10): 1566. CrossRef
ERCC1 Overexpression Increases Radioresistance in Colorectal Cancer Cells
Yi-Jung Huang, Ming-Yii Huang, Tian-Lu Cheng, Shih-Hsun Kuo, Chien-Chih Ke, Yi-Ting Chen, Yuan-Chin Hsieh, Jaw-Yuan Wang, Chiu-Min Cheng, Chih-Hung Chuang
Cancers.2022; 14(19): 4798. CrossRef
Dietary Nonstarch Polysaccharide Intake and Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
Cancer Research Communications.2022; 2(10): 1304. CrossRef
Expression of Vascular Endothelial Growth Factor (VEGF) in Colorectal Adenoma and Carcinoma in a Tertiary Care Center
Subalakshmi Balasubramanian, Nagarajan Priyathersini, Thanka Johnson
Cureus.2022;[Epub] CrossRef
Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review
Wei-Jian Mei, Mi Mi, Jing Qian, Nan Xiao, Ying Yuan, Pei-Rong Ding
Frontiers in Immunology.2022;[Epub] CrossRef
Diagnosis by Volatile Organic Compounds in Exhaled Breath from Patients with Gastric and Colorectal Cancers
Jinwook Chung, Salima Akter, Sunhee Han, Yoonhwa Shin, Tae Choi, Insug Kang, Sung Kim
International Journal of Molecular Sciences.2022; 24(1): 129. CrossRef
Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review
Nur Mahirah Amani Binti Mohammad, Mohd Razif Shahril, Suzana Shahar, Michael Fenech, Razinah Sharif
Journal of Cancer Prevention.2022; 27(4): 208. CrossRef
Inhibition of Cell Proliferation and Induction of Cell Cycle Arrest in Colon Cancer Cells by Lyophilized Mango (Mangifera indicaL.) Pulp Extract
Gustavo Argenor Lozano-Casabianca, Sandra Sulay Arango-Varela, Johanny Aguillón-Osma, María Alejandra Llano-Ramírez, María Elena Maldonado-Celis
Preventive Nutrition and Food Science.2022; 27(4): 436. CrossRef
Hereditary, environmental, and dietary risk factors of colorectal cancer: a case-control study in the Algerian East
Samira Negrichi, Salima Taleb
Environmental Science and Pollution Research.2021; 28(10): 12372. CrossRef
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study
Je-Ming Hu, Chia-Cheng Lee, Tzu-Chiao Lin, Chi-Hsiang Chung, Chao-Yang Chen, Pi-Kai Chang, Cheng-Wen Hsiao, Chien-An Sun, Nian-Sheng Tzeng, Wu-Chien Chien
Frontiers in Psychiatry.2021;[Epub] CrossRef
Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review
Hossein Mozafar Saadati, Batool Okhovat, Farzad Khodamoradi
Journal of Gastrointestinal Cancer.2021; 52(2): 414. CrossRef
Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort
Jung Min Moon, Jong Pil Im, Donghee Kim, Yoo Min Han, Hosim Soh, Ji Hyun Song, Sun Young Yang, Young Sun Kim, Jeong Yoon Yim, Seon Hee Lim, Joo Sung Kim
Journal of Gastroenterology and Hepatology.2021; 36(7): 1836. CrossRef
Dietary Intake as Determinant Nongenetic Factors to Colorectal Cancer Incidence and Staging Progression: A Study in South Sulawesi Population, Indonesia
Ika Nurlaila, Alam A. Hidayat, Arif Budiarto, Bharuno Mahesworo, Kartika Purwandari, Bens Pardamean
Nutrition and Cancer.2021; 73(11-12): 2523. CrossRef
Comparison of Risk of Metachronous Advanced Colorectal Neoplasia in Patients with Sporadic Adenomas Aged < 50 Versus ≥ 50 years: A Systematic Review and Meta-Analysis
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Journal of Personalized Medicine.2021; 11(2): 120. CrossRef
Survival of colorectal cancer patients in Brunei Darussalam: comparison between 2002–09 and 2010–17
Shirley H. F. Lee, Hanif Abdul Rahman, Nadiah Abidin, Sok King Ong, Elvynna Leong, Lin Naing
BMC Cancer.2021;[Epub] CrossRef
Schistosoma japonicum Associated With Colorectal Cancer
Anas Almoghrabi, Obaie Mzaik, Bashar Attar
ACG Case Reports Journal.2021; 8(5): e00572. CrossRef
Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity
Yoonsuk Jung, Eui Im, Jinhee Lee, Hyeah Lee, Changmo Moon
Journal of Personalized Medicine.2021; 11(6): 497. CrossRef
Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
The Korean Journal of Internal Medicine.2021; 36(5): 1083. CrossRef
Strategies for colorectal cancer screening and post-polypectomy surveillance for young adults under age 50
Yoon Suk Jung
Precision and Future Medicine.2021; 5(2): 69. CrossRef
CTSE Overexpression Is an Adverse Prognostic Factor for Survival among Rectal Cancer Patients Receiving CCRT
Chia-Lin Chou, Tzu-Ju Chen, Yu-Feng Tian, Ti-Chun Chan, Cheng-Fa Yeh, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
Life.2021; 11(7): 646. CrossRef
Risk-stratified colorectal cancer screening for optimal use of colonoscopy resources
Dong-Hoon Yang
The Korean Journal of Internal Medicine.2021; 36(4): 839. CrossRef
Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer
Kangkang Ying, Bingjun Bai, Xing Gao, Yuzi Xu, Hangxiang Wang, Binbin Xie
Frontiers in Bioengineering and Biotechnology.2021;[Epub] CrossRef
RNA-sequencing identification and validation of genes differentially expressed in high-risk adenoma, advanced colorectal cancer, and normal controls
Namjoo Kim, Jeong-An Gim, Beom Jae Lee, Byung il Choi, Seung Bin Park, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim, Han-Kyeom Kim
Functional & Integrative Genomics.2021; 21(3-4): 513. CrossRef
Metabolic Evidence Rather Than Amounts of Red or Processed Meat as a Risk on Korean Colorectal Cancer
Eunbee Kim, Joon Seok Lee, Eunjae Kim, Myung-Ah Lee, Alfred N. Fonteh, Michael Kwong, Yoon Hee Cho, Un Jae Lee, Mihi Yang
Metabolites.2021; 11(7): 462. CrossRef
Participation Rate, Risk Factors, and Incidence of Colorectal Cancer in the Screening Program Among the Population Covered by the Health Centers in Arak, Iran
Pegah Mohaghegh, Farzane Ahmadi, Mahjabin Shiravandi, Javad Nazari
International Journal of Cancer Management.2021;[Epub] CrossRef
Detection of Colon Polyps in India—A Large Retrospective Cohort Study (DoCPIr)
Nitin Jagtap, Aniruddha Pratap Singh, Pradev Inavolu, Manu Tandan, Shubhankar Godbole, Pranav Ambardekar, Anuradha Sekaran, Sundeep Lakhtakia, Mohan Ramchandani, Rakesh Kalapala, Rajesh Gupta, P. Manohar Reddy, Zaheer Nabi, Radhika Chavan, G. Venkat Rao,
Journal of Digestive Endoscopy.2021; 12(02): 063. CrossRef
Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers
Yu-Chan Chang, Ming-Hsien Chan, Chien-Hsiu Li, Chih-Yeu Fang, Michael Hsiao, Chi-Long Chen
Biomedicines.2021; 9(8): 931. CrossRef
Extricating the Association Between the Prognostic Factors of Colorectal Cancer
Younis Mohd, Balamuralikrishnan Balasubramanian, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Suresh Kumar Shanmugam, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Sasikala Keshavarao, Vijaya Anand Arumugam
Journal of Gastrointestinal Cancer.2021; 52(3): 1022. CrossRef
Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer
Marewan Abid, Fikry Qadir, Abbas Salihi
Oncology Letters.2021;[Epub] CrossRef
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer
T. Yoshino, G. Argilés, E. Oki, E. Martinelli, H. Taniguchi, D. Arnold, S. Mishima, Y. Li, B.K. Smruti, J.B. Ahn, I. Faud, C.E. Chee, K.-H. Yeh, P.-C. Lin, C. Chua, H.H. Hasbullah, M.A. Lee, A. Sharma, Y. Sun, G. Curigliano, H. Bando, F. Lordick, T. Yaman
Annals of Oncology.2021; 32(12): 1496. CrossRef
Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment
Shamin Azwar, Heng Fong Seow, Maha Abdullah, Mohd Faisal Jabar, Norhafizah Mohtarrudin
Biology.2021; 10(9): 854. CrossRef
Association of four genetic variants with colorectal cancer in Kazakhstan population
Yevgeniya Kolesnikova, Dmitriy Babenko, Irina Kadyrova, Svetlana Kolesnichenko, Lyudmila Akhmaltdinova, Ilya Korshukov, Naylya Kabildina, Valentina Sirota, Vera Zhumaliyeva, Dana Taizhanova, Dmitriy Vazenmiller, Anar Turmukhambetova
Oncotarget.2021; 12(21): 2215. CrossRef
Exosomal circRNAs: new players in colorectal cancer
Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar, Fatemeh Pakdaman
Cancer Cell International.2021;[Epub] CrossRef
Screening and prevention of colorectal cancer
Priyanka Kanth, John M Inadomi
BMJ.2021; : n1855. CrossRef
Can Real-time Computer-Aided Detection Systems Diminish the Risk of Postcolonoscopy Colorectal Cancer?
Mariusz Madalinski, Roger Prudham
JMIR Medical Informatics.2021; 9(12): e25328. CrossRef
Bioinformatic analysis reveals in common genes between colorectal cancer and recurrent colorectal malignancy
Rasoul Nemati, Mehdi Valizadeh, Mehrdad Mohammadi, Atena Kamali
Gene Reports.2021; 25: 101375. CrossRef
Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study
Godfrey Wekha, Nelson Ssewante, Angelique Iradukunda, Micheal Jurua, Shadia Nalwoga, Sharon Lanyero, Ronald Olum, Felix Bongomin
Cancer Management and Research.2021; Volume 13: 7697. CrossRef
Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review
Sharifah Saffinas Syed Soffian, Azmawati Mohammed Nawi, Rozita Hod, Huan-Keat Chan, Muhammad Radzi Abu Hassan
International Journal of Environmental Research and Public Health.2021; 18(19): 10486. CrossRef
Endoscopic submucosal dissection versus endoscopic mucosal resection for rectal carcinoid tumor. A meta‐analysis and meta‐regression with single‐arm analysis
Jie Ning Yong, Xiong Chang Lim, Kameswara Rishi Yeshayahu Nistala, Lincoln Kai En Lim, Grace En Hui Lim, Jingxuan Quek, Hui Yu Tham, Neng Wei Wong, Ker‐Kan Tan, Choon Seng Chong
Journal of Digestive Diseases.2021; 22(10): 562. CrossRef
Detection of Microsatellite Instability in Colorectal Cancer Patients With a Plasma-Based Real-Time PCR Analysis
Namjoo Kim, Sung Min Kim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim
Frontiers in Pharmacology.2021;[Epub] CrossRef
The Relationship Between Severity of Gastric Inflammation Due to Helicobacter pylori and Colorectal Malignancies
Oktay BULUR, Evrim Kahramanoğlu AKSOY, Gülçin GÜLER ŞİMŞEK, Murat ESER, Zeliha ASİLTÜRK LÜLLECİ, Kürşat DAL, Metin UZMAN
Cumhuriyet Medical Journal.2021;[Epub] CrossRef
Histomorphology Panorama of Neoplastic Gastrointestinal Lesions in a Tertiary Care Center
Sunita Bamanikar, Dayanand Sonkawade, Parul Bhandari, Arvind Bamanikar, Shirish Chandanwale, Archana Buch
Medical Journal of Dr. D.Y. Patil Vidyapeeth.2021; 14(1): 31. CrossRef
Clinical, Endoscopic and Histological Profile of Colorectal Cancers Seen on Colonoscopy in Kano, North-Western Nigeria
Yusuf Musa, Mansur Femi Mohammed, Nurudeen Olalekan Muhammad, Ibrahim Yusuf, Abdulrashid Onimisi Abdulrahim, Adamu Alhaji Samaila, Musa Muhammad Borodo
Nigerian Postgraduate Medical Journal.2021; 28(1): 22. CrossRef
Risk of developing metachronous advanced colorectal neoplasia after resection of low-risk diminutive versus small adenomas
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Gastrointestinal Endoscopy.2020; 91(3): 622. CrossRef
miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells
Fanhua Kong, Heng Zou, Xi Liu, Jun He, Yanwen Zheng, Li Xiong, Xiongying Miao
Photodiagnosis and Photodynamic Therapy.2020; 29: 101663. CrossRef
Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer
Ayat B. Al-Ghafari, Khadijah S. Balamash, Huda A. Al Doghaither
Saudi Journal of Biological Sciences.2020; 27(3): 827. CrossRef
Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma
Heng Zhang, Yusheng Liao, Hongfeng Zhang, Jie Wu, Dan Zheng, Zhitao Chen
The International Journal of Biological Markers.2020; 35(1): 19. CrossRef
Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery
Yun Sik Choi, Wan Soo Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Intestinal Research.2020; 18(1): 96. CrossRef
Fisetin suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway
Qingling Fan, Xiaoye Wang, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Qingkui Wang
Journal of King Saud University - Science.2020; 32(3): 1959. CrossRef
The relationship between metabolic syndrome and the incidence of colorectal cancer
JungHyun Lee, Kun Sei Lee, Hyeongsu Kim, Hyoseon Jeong, Min-Jung Choi, Hai-Won Yoo, Tae-Hwa Han, Hyunjung Lee
Environmental Health and Preventive Medicine.2020;[Epub] CrossRef
Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions
Lorenzo Polimeno, Michele Barone, Adriana Mosca, Maria Teresa Viggiani, Farahnaz Joukar, Fariborz Mansour-Ghanaei, Sara Mavaddati, Antonella Daniele, Lucantonio Debellis, Massimo Bilancia, Luigi Santacroce, Alfredo Di Leo
Microorganisms.2020; 8(4): 469. CrossRef
Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer
Sun Young Kim, Tae Won Kim
ESMO Open.2020; 5(2): e000634. CrossRef
Strategies to Increase the Participation Rate of Colorectal Cancer Screening
Yoon Suk Jung
Gut and Liver.2020; 14(3): 277. CrossRef
The incidence and patterns of colorectal cancers in Sri Lanka from 2001 to 2010: Analysis of national cancer registry data
Umesh Jayarajah, Viraj Udayanga, Ashan Fernando, Dharmabandhu N. Samarasekera, Sanjeewa Seneviratne
European Journal of Cancer Care.2020;[Epub] CrossRef
The association between Ki-67 expression and the clinical pathological characteristics of colorectal cancer
Jing Li, Zhi-ye Liu, Hai-bo Yu, Xiu-sheng Qu, Qing Xue, Hai-tao Yu, Christina Weeks
Medicine.2020; 99(21): e19996. CrossRef
Detection of colon cancer based on microarray dataset using machine learning as a feature selection and classification techniques
A. S. M. Shafi, M. M. Imran Molla, Julakha Jahan Jui, Mohammad Motiur Rahman
SN Applied Sciences.2020;[Epub] CrossRef
Hospital-Based Preliminary Observations of Dietary Intake and Physical Activity in Saudi Patients with Colorectal Polyps: A Call for Nutrition Care Integration after Polypectomy Procedure
Areej Ali Alkhaldy
Gastrointestinal Disorders.2020; 2(2): 96. CrossRef
Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model
David Bars-Cortina, Ana Martínez-Bardají, Alba Macià, María-Jose Motilva, Carme Piñol-Felis
The Journal of Nutritional Biochemistry.2020; 83: 108418. CrossRef
circPDSS1 Stimulates the Development of Colorectal Cancer via Activating the Wnt/β-Catenin Signaling

Qun Fang, Aijie Yang, Anshan Dong, Ligang Zhao
OncoTargets and Therapy.2020; Volume 13: 6329. CrossRef
Colorectal Cancer Genetics, Incidence and Risk Factors: In Search for Targeted Therapies

Rodney Hull, Flavia Zita Francies, Meryl Oyomno, Zodwa Dlamini
Cancer Management and Research.2020; Volume 12: 9869. CrossRef
Radiological staging of rectal cancer in a resource limited setting
Naradha Lokuhetty, Suranjith L. Seneviratne, Fathima Asma Rahman, Thanushka Marapana, Roshan Niloofa, Ishan De Zoysa
BMC Research Notes.2020;[Epub] CrossRef
Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer
Yoon Suk Jung, Jinhee Lee, Hye Ah Lee, Chang Mo Moon
Journal of Clinical Medicine.2020; 9(10): 3302. CrossRef
Relationship analysis of the miR-196a2 polymorphism (rs11614913) with colorectal cancer risk in southern Khorasan, eastern Iran
Malaksima Ayadilord, Tahmine Tavakoli, Tahereh Fakharian, Ehsan Soltaninejad, Mohsen Naseri
Meta Gene.2020; 26: 100813. CrossRef
Expression of Main Toll-Like Receptors in Patients with Different Types of Colorectal Polyps and Their Relationship with Gut Microbiota
Sama Rezasoltani, Reza Ghanbari, Mehdi Azizmohammad Looha, Ehsan Nazemalhosseini Mojarad, Abbas Yadegar, Delisha Stewart, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
International Journal of Molecular Sciences.2020; 21(23): 8968. CrossRef
Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
Pi-Yueh Chang, Shih-Cheng Chang, Mei-Chia Wang, Jinn-Shiun Chen, Wen-Sy Tsai, Jeng-Fu You, Chia-Chun Chen, Hsiu-Ling Liu, Jy-Ming Chiang
Cancers.2020; 12(12): 3560. CrossRef
Obesity Has a Stronger Relationship with Colorectal Cancer in Postmenopausal Women than Premenopausal Women
Ji Won Chang, Dong Wook Shin, Kyung Do Han, Keun Hye Jeon, Jung Eun Yoo, In Young Cho, Yun Jin Choi, Jung Yong Hong
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(11): 2277. CrossRef
The significance of colorectal cancer in the morbidity and mortality of the adult population of the South Banat District in the period from 2010 to 2019
Aleksandra Perović, Jasmina Pavlović-Stojanović, Ljiljana Lazić, Dragana Antonijević-Đorđević, Magdalena Bjelica, Ivana Popov, Veronika Popovski
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Prevalence and risk factors of colorectal cancer in Asia

Intest Res. 2019;17(3):317-329. Published online May 20, 2019

DOI: https://doi.org/10.5217/ir.2019.00021

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Prevalence and risk factors of colorectal cancer in Asia

Fig. 1. Estimated 5-year cancer prevalent cases in 2018 (top 10). There were 4,789,635 patients (2,595,326 men and 2,194,309 women) who had been diagnosed as having colorectal cancer within the previous 5 years. Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Fig. 2. The 5-year prevalence of colorectal cancer in Asia, 2018. China, Japan, Korea, Malaysia, Singapore, and Turkey had higher 5-year prevalence rates than that in others area (≥46.5/100,000). Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Fig. 1.

Fig. 2.

Prevalence and risk factors of colorectal cancer in Asia

Population	5-Year prevalent case	5-Year prevalence^a	New	Crude incidence^a	Age-standardized incidence^a	Death	Crude mortality^a	Age-standardized mortality^a
Asia	2,356,976	51.9^b	957,896	21.1^b	17.7^b	461,422	10.2^b	8.3^b
Europe	1,403,877	188.7^d	499,667	67.2^d	30.0^c	242,483	32.6^d	12.6^c
North America	534,049	146.8^d	179,771	49.4^d	26.2^c	64,121	17.6^c	8.4^b
Latin America and the Caribbean	315,005	48.3^b	128,006	19.6^b	16.8^b	64,666	9.9^b	8.1^b
Africa	113,625	8.8^b	61,846	4.8^b	8.2^b	40,034	3.1^b	5.5^b
Oceania	66,103	160.2^d	22,332	54.1^d	33.1^c	8,066	19.5^c	10.7^c
World	4,789,635	62.8	1,849,518	24.2	19.7	880,792	11.5	8.9

Population	5-Year prevalent case	5-Year prevalence^a	New case	Crude incidence^a	Age-standardized incidence^a	Death	Crude mortality^a	Age-standardized mortality^a
China	1,248,644	87.7^c	521,490	36.6^c	23.7^c	247,563	17.4^c	10.9^c
Japan	431,679	339.4^d	148,151	116.5^d	38.9^d	57,910	45.5^d	12.0^c
Korea	122,933	240.3^d	42,363	82.8^d	44.5^d	9,762	19.1^c	8.7^c
India	113,046	8.3^b	56,751	4.2^b	4.4^b	43,090	3.2^b	3.4^b
Indonesia	66,175	24.8^b	30,017	11.3^b	12.1^b	16,386	6.1^b	6.9^b
Turkey	49,614	60.6^c	20,031	24.5^c	21.0^c	10,033	12.2^c	10.2^c
Thailand	42,417	61.3^c	17,534	25.3^c	15.5^b	9,462	13.7^c	8.4^c
Philippines	34,268	32.2^b	15,680	14.7^b	18.9^c	8,821	8.3^b	11.0^c
Vietnam	32,895	34.1^b	14,733	15.3^b	13.4^b	8,104	8.4^b	7.0^b
Iran	24,345	29.7^b	9,864	12.0^b	12.9^b	4,153	5.1^b	5.6^b
Asia	2,356,976	51.9	957,896	21.1	17.7	461,422	10.2	8.3

Table 1. Estimated Worldwide Epidemiology of Colorectal Cancer in 2018

Proportions per 100,000.

Rate < world proportion.

Rate ≥ world proportion & < 2×world proportion.

Rate ≥ 2×world proportion.

Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].

Table 2. Estimated Epidemiology of Colorectal Cancer in Asia, 2018

Proportions per 100,000.

Rate < world proportion.

Rate ≥ world proportion & <2×world proportion.

Rate ≥ 2×world proportion.

Data source: International Agency for Research on Cancer, GLOBOCAN 2018, World Health Organization (WHO) [4].