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Published online April 29, 2021.
Could the geographic area influence the demographic profile of IBD patients in India?
Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry

Ajit Sood, Kirandeep Kaur, Ramit Mahajan, et al. Intest Res. 2021;19(2):206-216

In India, the incidence of UC (6.02/100,000) is much higher than that of other Asian countries, and an increasing incidence of CD has been reported in this country. National population-based registries are necessary to analyze the external validity of randomized controlled trials, natural disease course, response to treatment and survival rates of a specific disease. To this aim, a multicenter, cross-sectional, prospective registry was established across the four geographical zones of India. Based on the registry, this study analyzed the demographics, disease features, complications, and treatment history of IBD in India.

  1. A total of 3,863 patients (mean age, 36.7 ± 13.6 years; 3,232 UC [83.7%] and 631 CD [16.3%]) were enrolled. The UC:CD ratio was 5.1:1 and showed a male predominance (male:female = 1.6:1).
  2. The results of national IBD registry show significant differences in the demographic profile of the patient cohorts from the 4 geographical regions of India.

    1) The majority of patients with UC (n = 1,870, 57.9%) were from north whereas CD was more common in south (n = 348, 55.5%). The UC:CD ratio was 8 times higher in north (11.4:1) than south (1.4:1).

    2) Regarding disease severity of UC, nearly three-fourths of the patients in the northern cohort had moderately severe disease (n =1,394,74.5%), while a similar proportion in eastern cohort had mild disease (n=198, 76.2%).

    3) There was a significant regional variation in the disease location of CD (P<0.001). The most common locations were L1 (46.3%); L2 (59.7%), and L3 (49.1%) in the northern, western and southern cohorts, respectively.

    4) Nearly all patients (99.0%) received aminosalicylates. Biologics were used in only 1.5% of patients; more commonly for UC in north and CD in south.
Read more about the demographics, clinical presentation, and prescribing patterns for management of UC and CD in 4 geographical zones of India.

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