How often is immunoglobulin A nephropathy associated in patients with inflammatory bowel diseases?

Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, et al. Intest Res. 2021;19(4):430-437

Immunoglobulin A nephropathy (IgAN) is generally considered a primary disease, but it can occur secondary to a variety of immune-mediated diseases. In patients with inflammatory bowel diseases, IgAN is known as a rare complication. This rare renal complication may be a serious disease that can lead to end-stage renal failure that requires dialysis, but information regarding its prevalence in inflammatory bowel diseases is lacking so far. Therefore, the authors of this study investigated the frequency of IgAN in patients with inflammatory bowel diseases using a retrospective cohort of a single institute. A total of 427 patients with inflammatory bowel diseases (220 ulcerative colitis and 207 Crohn’s disease) were enrolled.

In this study, the overall incidence of IgAN in patients with inflammatory bowel diseases was 3.0% (1.4% of suspected IgAN and 1.6% of biopsy proven IgAN).
The frequency of IgAN was significantly higher in patients with Crohn’s disease than in those with ulcerative colitis (CD 5.3% vs. UC 0.9%, P<0.01).
In patients with Crohn’s disease, ileostomy or colostomy formation was significantly related with IgAN.

Read more about the association between inflammatory bowel diseases and IgAN.

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