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Published online August 1, 2022.
Is bile acid metabolism related to dysbiosis in patients with Crohn’s disease?
Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease

Shigeki Bamba, Osamu Inatomi, Atsushi Nishida, Masashi Ohno, Takayuki Imai, Kenichiro Takahashi, Yuji Naito, Junichi Iwamoto, Akira Honda, Naohiro Inohara, Akira Andoh. Intest Res. 2022;20(3):370-380

The pathogenesis of inflammatory bowel disease (IBD) is not yet fully understood, but the gut microbiome imbalance is believed to play a role in initiating and sustaining IBD. Bile acids are metabolized by the gut microbiota and are known to regulates hemeostasis of the gastrointestinal tract. However, how are they associated each other between bile acid metabolism and changes in the gut microbiome? How does it appear specifically in patients with IBD?

The present study analyzed the mucosal associated microbiome and bile acid metabolites in the small intestine of patients with Crohn’s disease. Samples were obtained using balloon assisted enteroscopy. Bile acid composition was analyzed by liquid chromatography-mass spectrometry. Mucosal samples were obtained from the ileum using balloonand the gut microbiota was analyzed by 16S rRNA gene sequencing.

  1. In this study, bile acid composition in the ileum of CD patients altered, but it was relatively modest as compared to previously reported findings.
  2. The abundance of the genera Escherichia and Lactobacillus was positively correlated with the proportion of conjugated bile acids.
  3. The abundance of the family Lachnospiraceae (the genus Roseburia), Peptostreptococcaceae (Intestinibacter), and Ruminococcaceae (Faecalibacterium) was negatively correlated with the proportion of conjugated bile acids.
  4. The comparison of bile acid fraction between active and inactive CD revealed significantly decreased level of glycodeoxycholic acid, a conjugated secondary bile acid, in active CD.
Read more about bile acid composition and dysbiosis in the patients with IBD.

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