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HOME > Intest Res > Volume 21(3); 2023 > Article
Original Article Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD
Arshdeep Singh1,*, Yogesh Kumar Gupta1,*, Ashvin Singh Dhaliwal2, Bhavjeet Kaur Kahlon2, Vasu Bansal2, Ramit Mahajan1, Varun Mehta1, Dharmatma Singh3, Ramandeep Kaur3, Namita Bansal3, Vandana Midha2, Ajit Sood1
Intestinal Research 2023;21(3):375-384.
DOI: https://doi.org/10.5217/ir.2022.00037
Published online: October 18, 2022

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Correspondence to Ajit Sood, Department of Gastroenterology, Dayanand Medical College, Ludhiana 141001, Punjab, India. Tel: +91-9815-400-718, Fax: +91-161-2302620, E-mail: ajitsood10@gmail.com
Co-Correspondence to Vandana Midha, Department of Internal Medicine, Dayanand Medical College, Ludhiana 141001, Punjab, India. Tel: +91-9815-528-289, Fax: +91-161-2302620, E-mail: vandana_midha2@yahoo.co.in
*These authors contributed equally to this study.
• Received: March 23, 2022   • Revised: June 25, 2022   • Accepted: June 29, 2022

© Copyright 2023. Korean Association for the Study of Intestinal Diseases.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Background/Aims
    The inflammatory bowel disease (IBD)-disk is a validated, visual, 10-item, self-administered questionnaire used to evaluate IBD-related disability. The present study aimed to evaluate IBD-disk in assessment of IBD daily life burden and its relation with disease activity.
  • Methods
    A cross-sectional study was conducted between June 2021 and December 2021. Patients with IBD were asked to complete the IBD-disk and a visual analogue scale of IBD daily-life burden (scored from 0–10, score >5 indicative of high burden). The internal consistency of IBD-disk, correlation with IBD daily life burden and disease activity (assessed by partial Mayo score and Harvey Bradshaw Index in patients with ulcerative colitis [UC] and Crohn’s disease [CD], respectively) and diagnostic performance of IBD-disk to detect high burden were analyzed.
  • Results
    Out of the 546 patients (mean age 40.33±13.74 years, 282 [51.6%] males) who completed the IBD-disk, 464 (84.98%) had UC and the remaining (n=82, 15.02%) had CD. A total of 311 patients (291 UC and 20 CD; 56.95%) had active disease. The mean IBD-disk total score and IBD daily life burden were 18.39±15.23 and 2.45±2.02, respectively. The IBD-disk total score correlated strongly with the IBD daily life burden (ρ=0.94, P<0.001), moderately with partial Mayo score (ρ=0.50) and weakly with Harvey Bradshaw Index (ρ=0.34). The IBD-disk total score >30 predicted high IBD daily-life burden.
  • Conclusions
    The IBD-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD and can be applied in clinical practice. (Intest Res, Published online)
  • Keywords: Crohn disease; Ulcerative colitis; Inflammatory bowel diseases; Disability; Patient reported outcome measures
The treatment of inflammatory bowel disease (IBD), including both ulcerative colitis (UC) and Crohn’s disease (CD), is focused on clinical, endoscopic, and/or histological healing; and the importance of disease-related disability and quality of life is often underestimated [1]. Disability, as defined by the World Health Organization, includes impairments, limitations, and restrictions to perform/participate in an activity or involvement in life situations [2]. The concept of disability in IBD remained subjective until the development of IBD-specific disability indices in the last decade. The IBD disability index, a comprehensive 28-item validated questionnaire, remains the most commonly used index to assess disability in patients with IBD [3]. However, its complexity limits its use in routine clinical practice. To overcome this limitation, IBD-disk, a self-administered tool evaluating different dimensions of patient-reported outcome measures of quality of life was developed [4]. The IBD-disk has been recently validated in a large European IBD cohort [5].
The patient acceptability, understanding, and response to self-administered tools like IBD-disk are influenced by the local socio-cultural sensitivities and practices [6]. The universal application of IBD-disk therefore cannot be advocated until it is analyzed in different populations. We aimed to evaluate the real-life performance of the IBD-disk in assessing the IBD-related disability by correlating it with IBD daily life burden and the disease activity.
1. Study Population
This is a cross-sectional study of patients with IBD (both UC and CD) who attended the outpatient clinic at Dayanand Medical College and Hospital Ludhiana, India between June 2021 and December 2021. Consecutive adult ( ≥ 18 years) patients with an established diagnosis of IBD (based on European Crohn’s and Colitis Organisation and the European Society of Gastrointestinal and Abdominal Radiology guidelines) [7] were asked to complete the standardized IBD-disk questionnaire. Patient demographics (age and sex) and disease characteristics (disease duration, classification, and activity) were recorded simultaneously. Non-consenting patients or patients who were unable to comprehend the IBD-disk questionnaire were excluded. The study was approved by the Institutional Ethics Committee (IEC No. DMCH/R&D/2020/23). All the authors had access to the study data.
2. IBD-Disk Tool
The IBD-disk includes 10 components (joint pain, abdominal pain, body image, education and work, emotions, energy, interpersonal interactions, regulation of defecation, sexual function, and sleep) (Supplementary Fig. 1). Each component is scored from 0 to 10 using a visual analogue scale (0, no disability; 10, maximal disability). The IBD-disk total score was calculated as the sum of the 10 individual component subscores (minimum score 0 and maximum score 100) [4,8,9]. An additional visual analogue scale was added to assess the IBD daily life burden (0 perfect and 10 worst, > 5 indicated high burden).
3. Assessment of Disease Activity
Patients with both UC and CD were classified according to the Montreal classification [10]. Disease activity was assessed using partial Mayo Clinic score (PMS) in patients with UC and Harvey Bradshaw Index (HBI) in patients with CD. Active UC was defined as PMS > 1 while active CD was defined as HBI ≥ 5 [11-13].
4. Statistical Analysis
The quantitative data were expressed as mean ± standard deviation and the qualitative data as frequency. The associations between IBD-disk total score and patient and disease characteristics were evaluated using the Mann‐Whitney test. A probability value of < 0.05 was considered statistically significant. Spearman’s correlation coefficient (ρ) was applied to assess the correlation between IBD-disk total score, IBD-disk subscores, IBD daily life burden, and disease activity. The values of ρ between 0.1–0.39, 0.40–0.69, 0.70–0.89, and ≥ 0.90 were interpreted as weak, moderate, strong, and very strong correlations, respectively [14]. The internal consistency (or homogeneity) of the IBD-disk was assessed using Cronbach’s coefficient (α). Cronbach’s α > 0.7 and Cronbach’s corrected item correlation > 0.4 were considered significant. The area under the receiver operating characteristic (AUROC) curve was calculated to determine the accuracy of the IBD-disk total score to detect a high IBD daily life burden. All the statistical calculations were done using the SPSS version 21.0 (IBM Corp., Armonk, NY, USA).
During the study period, a total of 613 patients were asked to complete the IBD-disk questionnaire. After exclusion of the patients with incomplete questionnaires, 546 patients (84.9%; mean age, 40.33 ± 13.74 years, 282 males [51.6%]) were enrolled and analyzed. The majority of the patients (n = 464, 84.98%) had UC. Out of the 546 patients, 311 patients (56.95%) had the active disease (291 UC and 20 CD), while the remaining 235 patients (173 UC and 62 CD) were in remission. The baseline characteristics of the study population are summarized in Table 1.
1. Correlation between IBD-Disk and IBD Daily Life Burden
The mean IBD-disk total score of the enrolled patients was 18.39 ± 15.23. The mean IBD-disk subscores ranged between 0.07 (sexual functions) and 4.40 (energy). Forty-four patients (8.05%; 38 UC and 6 CD) had high IBD daily life burden. The mean IBD daily life burden score was 2.45 ± 2.02.
There was a strong correlation between the IBD-disk total score and the IBD daily life burden (ρ = 0.94, P< 0.001). The box plot of the distribution of the IBD daily life burden and the IBD-disk total score is depicted in Fig. 1.
On analyzing the subscores of the IBD-disk, 3 components (emotions, energy, and education and work) had a strong correlation, 6 components (abdominal pain, joint pain, body image, sleep, interpersonal interactions, and regulating defecation) had a moderate correlation while sexual functions had a weak correlation with the IBD daily life burden score. The correlations between IBD-disk subscores and IBD daily life burden in patients with UC and CD are summarized in Table 2. The correlations between IBD daily life burden, and abdominal pain, and emotions were significantly higher in females with IBD. On subgroup analysis, the IBD daily life burden in UC correlated significantly with abdominal pain, emotions and education and work in females. In patients with CD, however, no sex-based differences were observed in correlations of IBD-disk subscores and IBD daily life burden (Supplementary Table. 1).
2. Homogeneity of IBD-Disk
Cronbach’s α calculated for the IBD-disk total score was 0.82. To test the contribution and consistency of the IBD-disk, one-at-a-time deletion of different items was done. The Cronbach’s α (if item deleted) varied between 0.78 and 0.83 for all the 10 individual components of the IBD-disk. The corrected item-total correlations were > 0.4 for all the subscores except joint pain and sexual functions (Table 3). Cronbach’s α was positive for each pair of IBD-disk components except (sexual function+sleep) and (sexual function+abdominal pain). The highest correlations were seen for (energy+emotions) and (emotions+body image) (Fig. 2).
3. Correlation between IBD-Disk and Disease Activity
The IBD-disk total score correlated moderately with PMS (ρ = 0.50) and weakly with HBI (ρ = 0.34). The IBD daily life burden score had a moderate correlation with both PMS (ρ= 0.48) and HBI (ρ= 0.41). Amongst the IBD-disk subscores, regulating defecation had the maximum correlation with both PMS and HBI (Supplementary Table. 2). Patients with active disease had higher mean values for the IBD-disk total score, IBD-disk subscores, and the IBD daily life burden as compared to patients who were in remission (Fig. 3).
The correlations of IBD-disk total score and subscores with IBD daily life burden were compared for patients with active disease and disease in remission. The IBD-disk total score correlated more strongly with IBD daily life burden in patients with UC in remission than patients with active UC, the difference being significant (0.95 vs. 0.91, P= 0.01 for UC and 0.93 vs. 0.92, P= 0.40 for CD). Except for energy in patients with UC and education and work for patients with CD, there was no effect of disease activity on the correlations of IBD-disk subscores with IBD daily life burden (Table 4).
4. Association between Disease Characteristics and Disability Assessed Using IBD-Disk and IBD Daily Life Burden
The IBD-disk or IBD daily life burden scores were not influenced by the type of IBD (UC or CD). The IBD-disk total score, IBD-disk subscores (except sexual function) and IBD daily life burden were higher in females (Table 5, Supplementary Table. 3).
A significant association of IBD-disk total score and IBD daily life burden was also observed with PMS in patients with UC and with HBI in patients with CD (Table 5). For both UC and CD, the mean IBD-disk scores increased with increasing disease activity (patients with mild disease activity had higher IBD-disk scores than patients in remission, but lower scores as compared to patients with moderate and severe disease). The trend was statistically significant (Table 5, Supplementary Table. 4).
There was no effect of age on the IBD-disk total score and IBD daily life burden. However, the mean IBD disk subscores of joint pains and sleep increased with increasing age. On subgroup analysis, younger adults (age < 40 years) with UC had higher mean scores for the body image subscore, as compared to older adults ( > 40 years) and elderly ( > 60 years). In contrast, older adults and elderly with CD had higher mean scores for joint pains (Supplementary Table. 5).
5. Diagnostic Accuracy of IBD-Disk
The diagnostic accuracy of the IBD-disk total score in predicting a high IBD daily-life burden ( > 5) was evaluated by calculating the AUROC, which was 0.96 (95% confidence interval, 0.94–0.98; P< 0.001) (Fig. 4). The threshold value for the IBD-disk total score to detect high IBD daily life burden was derived from coordinates of the receiver operating characteristic curve using the Youden Index. The IBD-disk total score > 30 predicted a high IBD daily life burden with a sensitivity of 95% and specificity of 85%.
For IBDs, patient-reported outcome measures evaluating both the disease activity as well as disability (and/or quality of life) are important to improve the long-term outcome and add value to the holistic IBD care. IBD disability index and IBD-disk are the 2 disability indices that have been validated in the European cohorts [3-5,15]. However, to ensure that the data captured by disability indices reflects the true picture, it is important that the survey tool is adapted to the respective populations. An ideal tool would perform uniformly across culturally diverse populations (cross-cultural equivalence) [16]. In the present study, we evaluated the real-world performance of IBD-disk to predict high IBD daily life burden in a large cohort of north Indian patients.
The mean IBD-disk total score was 18.39 ± 15.23 (range, 0–76). The IBD-disk total scores in the current study were lower than those reported in the west [5,8,9]. This could be attributed to either a differential perception of well-being or a true lower disability in the enrolled patients. The mean sexual function subscore was the lowest which is inconsistent with the impaired sexual function reported in IBD patients [17,18]. In the current study, only 4 participants (0.73%) reported a sexual function subscore of ≥ 5 on the IBD-disk. Low sexual function scores could indicate hesitation on the part of patients in the current cohort to report their intimate experiences. Another IBD-disk component that scored low was the body image. There is evidence to suggest that body image dissatisfaction can negatively impact patients and is associated with poorer quality of life [19]. However, patients in the current study did not report any significant alteration in the perceived body image. In observant societies like India, therefore, the inclusion of sexual function and body image in the IBD-disk is expected to result in lower total and hence lower cutoff scores of the IBD-disk in predicting a high disability burden. This was observed in the current study where IBD-disk total score > 30 predicted high IBD daily life burden as compared to the threshold values of ≥ 40, as described previously [8].
The IBD-disk total score correlated very strongly with IBD daily life burden (ρ= 0.94). There were no significant differences in the IBD-disk total score and IBD-disk subscores in patients with UC and CD, indicating a similar level of disability in both the types of IBD, consistent with the findings of the VALIDate study [5]. With a Cronbach’s α of 0.82, the IBD-disk displayed good internal consistency to assess the disease-related disability.
The IBD-disk total score had a significant association with the female sex. Similar findings were also observed in the VALIDate study [5]. Higher disability scores in females are consistent with gender differences in the perception of psychosocial domains of disability. Depression, fatigue, and a lower quality of life have been reported more frequently in females [20,21]. The higher prevalence of extra-intestinal manifestations (such as arthralgia, arthritis, and osteopenia) in females and a social bias against females in conservative societies also contributes to higher disease-related disability in females.
Higher IBD-disk total scores were observed in patients with higher disease activity scores. Interestingly, the age, disease duration, extent, location, and behavior did not affect the disability scores. A total of 25 (16 UC and 9 CD) patients had IBD-disk total score > 30 despite the disease being in clinical remission. These observations suggest that nearly 1 in 7 patients with UC and one in 2 patients with CD have high disability despite the disease being in remission. The IBD-disk subscores that scored high in such patients were emotions, energy and sleep. The IBD-disk thus facilitates assessment of the “non-gastrointestinal” disability experienced by such patients. Filling up the IBD-disk questionnaire by the patient at each visit to the healthcare facility, before seeing the treating physician, will allow a meaningful discussion between the two, focussing on the specific disability-related issues.
Although our study is limited by being a single-center study, the large sample size, with the disease spectrum mimicking the epidemiological characteristics of the local IBD population, is expected to reflect the actual burden of the disease. A greater number of patients in the current study had UC, as compared to the previous IBD-disk validation studies, where CD patients dominated the inclusion cohorts. Also, a majority of the patients enrolled in the current study had mild-moderate disease activity. This is also reflected in relatively infrequent use of biologics in the included cohort. The performance of IBD disk in patients with severe disease activity, hence, needs to be assessed in future studies, as disease activity is an important modifier of the disease-related disability. The IBD-disk tool was administered in the English language. Misinterpretation in patients not well versed or fluent in English cannot be ruled out, however, the proportion of such patients is expected to be very small. Translation and validation in regional languages are nevertheless required. As repeated assessments of the IBD-disk were not performed in the current study, the test-retest reliability could not be evaluated. This has, however, been reported earlier [22]. The long-term variability in IBD-disk scores also cannot be commented upon. The comparison of the IBD-disk with other disability indices such as IBD disability index was not done. Instead, IBD daily life burden was calculated using a unidimensional visual analogue scale. Similar approaches have been employed for other chronic diseases, and therefore the applicability of visual analogue scale in estimating the IBD daily life burden can be relied upon. The lack of endoscopic disease severity and inflammatory biomarkers such as fecal calprotectin or C-reactive protein did not allow objective assessment of the disease activity.
In conclusion, the IBD-disk is a consistent and accurate tool to determine IBD-related disability. It parallels the disease activity in patients with both UC and CD and is not affected by other disease characteristics, demonstrating the ubiquity of the tool, although gender specificity needs to be accounted for. The response to the IBD-disk is influenced by social and cultural beliefs. A universal cutoff of the IBD-disk cannot be recommended and population-specific thresholds thus need to be determined. Longitudinal studies with a more objective assessment of the disease activity and determinants of IBD-related disability are needed to evaluate the dynamicity of the IBD-disk in response to therapy.

Funding Source

The authors received no financial support for the research, authorship, and/or publication of this article.

Conflict of Interest

Sood A reports receiving honorarium for speaker events from Pfizer India and is an editorial board member of the journal but was not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.

Data Availability Statement

Not applicable.

Author Contribution

Conceptualization: Singh A, Midha V, Sood A. Data curation: Singh A, Gupta YK, Dhaliwal AS, Kahlon BK, Bansal V, Singh D, Kaur R. Formal analysis: Singh A, Dhaliwal AS, Kahlon BK, Bansal V, Bansal N. Investigation: Singh A, Singh D, Kaur R, Sood A. Methodology: Singh A, Midha V, Sood A. Project administration: Midha V, Sood A. Resources: Singh A, Midha V, Sood A. Supervision: Midha V, Sood A. Visualization: Singh A, A Dhaliwal AS, Kahlon BK, Bansal V. Writing - original draft: Singh A, Gupta YK, Dhaliwal AS, Kahlon BK, Bansal V, Sood A. Writing - review & editing: Singh A, Gupta YK, Dhaliwal AS, Kahlon BK, Bansal V, Mahajan R, Mehta V, Singh D, Kaur R, Bansal N, Midha V, Sood A. Approval of final manuscript: all authors.

Supplementary materials are available at the Intestinal Research website (https://www.irjournal.org).
Supplementary Table 1. Correlation between Different Components of the Inflammatory Bowel Disease (IBD)-Disk and IBD Daily Life Burden Score, Stratified by Sex
ir-2022-00037-Supplementary-Table-1.pdf
Supplementary Table 2. Correlation (Spearman’s Rho) between Inflammatory Bowel Disease (IBD)-Disk Total Score, IBD-Disk Sub Scores and IBD Daily Life Burden with Disease Activity Indices
ir-2022-00037-Supplementary-Table-2.pdf
Supplementary Table 3. Effect of Sex Differences on the Inflammatory Bowel Disease-Disk Subscores
ir-2022-00037-Supplementary-Table-3.pdf
Supplementary Table 4. Effect of Disease Activity on IBD-Disk Total Score and Subscores
ir-2022-00037-Supplementary-Table-4.pdf
Supplementary Table 5. Effect of Age on Inflammatory Bowel Disease (IBD)-Disk Scores and IBD Daily Life Burden
ir-2022-00037-Supplementary-Table-5.pdf
Supplementary Fig. 1. The inflammatory bowel disease (IBD)-disk. Each component is scored from 0 to 10 using a visual analogue scale (0, no disability 10, maximal disability). The IBD-disk total score is calculated as the sum of 10 individual component subscores.
ir-2022-00037-Supplementary-Fig-1.pdf
Fig. 1.
The box plot distribution of the inflammatory bowel disease (IBD)-disk total score and the IBD daily life burden. aThe extreme outlier was defined as a value that lies outside the following ranges: 3rd quartile+3*IQR; 1st quartile-3*IQR. IQR, interquartile range.
ir-2022-00037f1.jpg
Fig. 2.
Internal consistency for each pair of inflammatory bowel disease (IBD)-disk components.
ir-2022-00037f2.jpg
Fig. 3.
The mean inflammatory bowel disease (IBD)-disk and IBD daily life burden scores in the enrolled patients based on disease activity.
ir-2022-00037f3.jpg
Fig. 4.
Area under the receiver operating characteristic curve for prediction of high inflammatory bowel disease (IBD) daily life burden using the IBD-disk total score.
ir-2022-00037f4.jpg
Table 1.
Baseline Characteristics of the Enrolled Population
Characteristics Value (n = 546)
Age (yr) 40.33 ± 13.74
Male sex 282 (51.64)
Disease duration (yr) 6.20 ± 6.67
Type of inflammatory bowel disease
 Ulcerative colitis 464 (84.98)
 Crohn’s disease 82 (15.02)
Ulcerative colitis (n = 464)
 Disease extent
  E1 56 (12.07)
  E2 331 (71.34)
  E3 77 (16.59)
 Partial Mayo Clinic score 2.57 ± 2.04
  >1 291 (62.71)
  ≤1 173 (37.28)
Crohn’s disease (n = 82)
 Age at diagnosis < 17 yr 6 (7.31)
 Age at diagnosis 17–40 yr 40 (48.78)
 Age at diagnosis > 40 yr 36 (43.90)
 Ileal disease 38 (46.34)
 Colonic disease 23 (28.04)
 Ileo-colonic disease 18 (21.95)
 Upper gastrointestinal disease 3 (3.65)
 Non penetrating, non stricturing disease 41 (50.00)
 Stricturing disease 33 (40.24)
 Penetrating disease 8 (9.75)
 Perianal disease 3 (3.65)
 Harvey Bradshaw Index 3.54 ± 1.78
  ≥5 20 (24.39)
  <5 62 (75.60)
Concomitant treatmenta
 5-ASA 502 (91.94)
 Thiopurines 159 (29.12)
 Oral corticosteroids 60 (10.98)
 Anti-TNF (infliximab/adalimumab) 8 (1.46)
 Vedolizumab 1 (0.18)

Values are presnted as mean±standard deviation or number (%).

a Patients on combination therapies: 5-ASA+thiopurines (n=134, 24.54%); anti-TNF+thiopurines (n=5, 0.91%); vedolizumab+thiopurines (n=1, 0.18%).

E1, proctitis; E2, left sided colitis; E3, pancolitis; 5-ASA, 5-aminosalicylates; TNF, tumour necrosis factor.

Table 2.
Correlation between Different Components of the IBD-Disk and IBD Daily Life Burden Score
Variable Spearman’s rho
 Significance UC vs. CD
All patients (n=546) UC (n=464) CD (n=82) Z statistic P-value
Abdominal pain 0.52 0.52 0.54 –0.29 0.41
Joint pain 0.44 0.46 0.35 1.08 0.14
Sexual functions 0.12 0.13 NRa NRa NRa
Body image 0.61 0.61 0.62 –0.13 0.45
Emotions 0.81 0.82 0.78 0.91 0.18
Energy 0.77 0.78 0.68 1.78 0.04
Sleep 0.57 0.58 0.55 0.36 0.36
Education & work 0.73 0.73 0.80 –1.40 0.08
Interpersonal interactions 0.51 0.53 0.42 1.17 0.12
Regulating defecation 0.57 0.56 0.64 –1.03 0.15
IBD-disk total score 0.94 0.94 0.94 0 0.50

a All the patients reported a score of 0, hence no correlation coefficient value reported.

IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease.

Table 3.
Cronbach’s Coefficients (α) to Check the Internal Consistency of the Inflammatory Bowel Disease Disk
Variable Corrected item-total correlation Cronbach’s α if item deleted
Abdominal pain 0.48 0.81
Joint pain 0.37 0.83
Sexual functions 0.08 0.84
Body image 0.54 0.81
Emotions 0.73 0.78
Energy 0.65 0.79
Sleep 0.48 0.82
Education & work 0.71 0.79
Interpersonal interactions 0.49 0.82
Regulating defecation 0.54 0.81
Table 4.
Correlation (Spearman’s rho) of IBD-Disk Total Score and Subscores with IBD Daily Life Burden, Stratified According to Disease Activity
Variable Ulcerative colitis
 Crohn’s disease
Active disease Spearman’s rho (n=291) Disease in remission Spearman’s rho (n=173) z statistic P-value Active disease Spearman’s rho (n=20) Disease in remission Spearman’s rho (n=62) z statistic P-value
Abdominal pain 0.47 0.45 0.26 0.40 0.67 0.46 1.14 0.13
Joint pain 0.42 0.44 –0.25 0.40 0.19 0.44 –1.02 0.15
Sexual functions 0.09 0.20 –1.16 0.12 NRa NRa
Body image 0.56 0.60 –0.62 0.27 0.72 0.54 1.10 0.14
Emotions 0.80 0.81 –0.29 0.38 0.76 0.76 0 0.50
Energy 0.70 0.80 –2.39 0.01 0.47 0.73 –1.52 0.06
Sleep 0.58 0.52 0.89 0.19 0.69 0.54 0.89 0.19
Education & work 0.66 0.70 –0.77 0.22 0.90 0.74 1.90 0.03
Interpersonal interactions 0.51 0.45 0.87 0.21 0.32 0.46 –0.60 0.27
Regulating defecation 0.49 0.39 1.29 0.10 0.76 0.54 1.42 0.08
IBD-disk total score 0.91 0.95 –3.15 0.01 0.92 0.93 –0.25 0.40

a All the patients reported a score of 0, hence no correlation coefficient value reported.

IBD, inflammatory bowel disease; NR, not reported.

Table 5.
Association between Disease Characteristics and Disability Assessed Using IBD-Disk and IBD Daily Life Burden
Characteristics No. IBD-disk total score
 IBD daily life burden
Mean ± SD P-value Mean ± SD P-value
UC 464 18.39 ± 15.29 0.99 2.45 ± 2.05 0.92
CD 82 18.38 ± 14.97 2.43 ± 1.85
Sex 0.01 < 0.001
  Male 282 15.65 ± 13.84 2.09 ± 1.81
Female 264 21.27 ± 16.11 2.84 ± 2.16
Disease duration 0.65 0.99
≤ 2 yr 208 19.11 ± 14.68 2.46 ± 1.85
2–5 yr 120 17.58 ± 15.02 2.43 ± 2.04
> 5 yr 218 18.15 ± 15.89 2.44 ± 2.16
Disease extent (UC) 0.07 0.09
E1 56 13.96 ± 14.32 1.89 ± 1.89
E2 331 19.02 ± 14.89 2.53 ± 2.02
E3 77 18.90 ± 17.25 2.49 ± 2.22
Disease location (CD) 0.87 0.57
L1 38 17.82 ± 16.45 2.39 ± 1.91
L2 23 18.70 ± 13.01 2.61 ± 2.15
L3 18 20.11 ± 15.36 2.50 ± 1.38
L4 3 12.67 ± 11.01 1.00 ± 1.00
Disease behavior (CD) 0.19 0.29
B1 41 15.93 ± 11.00 2.17 ± 1.53
B2 33 19.61 ± 15.98 2.55 ± 1.87
B3 8 25.88 ± 25.07 3.25 ± 3.01
Disease activity (UC) < 0.001 < 0.001
Partial Mayo Clinic score
≤1 173 10.39 ± 11.17 1.50 ± 1.57
2–4 200 19.28 ± 13.54 2.48 ± 1.78
5–7 78 29.85 ± 14.77 4.00 ± 2.15
>7 13 42.38 ± 19.50 5.31 ± 2.59
Disease activity (CD) 0.01 0.01
Harvey Bradshaw Index
<5 62 16.06 ± 13.20 1.97 ± 1.34
5–7 17 22.18 ± 13.96 3.47 ± 2.30
8–16 3 44.67 ± 29.67 6.00 ± 2.65
> 16 Nil - -

IBD, inflammatory bowel disease; SD, standard deviation; UC, ulcerative colitis; CD, Crohn’s disease; E1, proctitis; E2, left sided colitis; E3, pancolitis; L1, ileal disease; L2, colonic disease; L3, ileo-colonic disease; L4, upper gastrointestinal disease; B1, non stricturing non penetrating disease; B2, stricturing disease; B3, fistulising disease.

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      Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD
      Intest Res. 2023;21(3):375-384.   Published online October 18, 2022
      DOI: https://doi.org/10.5217/ir.2022.00037
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    Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD
    Image Image Image Image
    Fig. 1. The box plot distribution of the inflammatory bowel disease (IBD)-disk total score and the IBD daily life burden. aThe extreme outlier was defined as a value that lies outside the following ranges: 3rd quartile+3*IQR; 1st quartile-3*IQR. IQR, interquartile range.
    Fig. 2. Internal consistency for each pair of inflammatory bowel disease (IBD)-disk components.
    Fig. 3. The mean inflammatory bowel disease (IBD)-disk and IBD daily life burden scores in the enrolled patients based on disease activity.
    Fig. 4. Area under the receiver operating characteristic curve for prediction of high inflammatory bowel disease (IBD) daily life burden using the IBD-disk total score.

    Fig. 1.

    Fig. 2.

    Fig. 3.

    Fig. 4.

    Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD
    Characteristics Value (n = 546)
    Age (yr) 40.33 ± 13.74
    Male sex 282 (51.64)
    Disease duration (yr) 6.20 ± 6.67
    Type of inflammatory bowel disease
     Ulcerative colitis 464 (84.98)
     Crohn’s disease 82 (15.02)
    Ulcerative colitis (n = 464)
     Disease extent
      E1 56 (12.07)
      E2 331 (71.34)
      E3 77 (16.59)
     Partial Mayo Clinic score 2.57 ± 2.04
      >1 291 (62.71)
      ≤1 173 (37.28)
    Crohn’s disease (n = 82)
     Age at diagnosis < 17 yr 6 (7.31)
     Age at diagnosis 17–40 yr 40 (48.78)
     Age at diagnosis > 40 yr 36 (43.90)
     Ileal disease 38 (46.34)
     Colonic disease 23 (28.04)
     Ileo-colonic disease 18 (21.95)
     Upper gastrointestinal disease 3 (3.65)
     Non penetrating, non stricturing disease 41 (50.00)
     Stricturing disease 33 (40.24)
     Penetrating disease 8 (9.75)
     Perianal disease 3 (3.65)
     Harvey Bradshaw Index 3.54 ± 1.78
      ≥5 20 (24.39)
      <5 62 (75.60)
    Concomitant treatmenta
     5-ASA 502 (91.94)
     Thiopurines 159 (29.12)
     Oral corticosteroids 60 (10.98)
     Anti-TNF (infliximab/adalimumab) 8 (1.46)
     Vedolizumab 1 (0.18)
    Variable Spearman’s rho
    		 Significance UC vs. CD
    All patients (n=546) UC (n=464) CD (n=82) Z statistic P-value
    Abdominal pain 0.52 0.52 0.54 –0.29 0.41
    Joint pain 0.44 0.46 0.35 1.08 0.14
    Sexual functions 0.12 0.13 NRa NRa NRa
    Body image 0.61 0.61 0.62 –0.13 0.45
    Emotions 0.81 0.82 0.78 0.91 0.18
    Energy 0.77 0.78 0.68 1.78 0.04
    Sleep 0.57 0.58 0.55 0.36 0.36
    Education & work 0.73 0.73 0.80 –1.40 0.08
    Interpersonal interactions 0.51 0.53 0.42 1.17 0.12
    Regulating defecation 0.57 0.56 0.64 –1.03 0.15
    IBD-disk total score 0.94 0.94 0.94 0 0.50
    Variable Corrected item-total correlation Cronbach’s α if item deleted
    Abdominal pain 0.48 0.81
    Joint pain 0.37 0.83
    Sexual functions 0.08 0.84
    Body image 0.54 0.81
    Emotions 0.73 0.78
    Energy 0.65 0.79
    Sleep 0.48 0.82
    Education & work 0.71 0.79
    Interpersonal interactions 0.49 0.82
    Regulating defecation 0.54 0.81
    Variable Ulcerative colitis
    		 Crohn’s disease
    Active disease Spearman’s rho (n=291) Disease in remission Spearman’s rho (n=173) z statistic P-value Active disease Spearman’s rho (n=20) Disease in remission Spearman’s rho (n=62) z statistic P-value
    Abdominal pain 0.47 0.45 0.26 0.40 0.67 0.46 1.14 0.13
    Joint pain 0.42 0.44 –0.25 0.40 0.19 0.44 –1.02 0.15
    Sexual functions 0.09 0.20 –1.16 0.12 NRa NRa
    Body image 0.56 0.60 –0.62 0.27 0.72 0.54 1.10 0.14
    Emotions 0.80 0.81 –0.29 0.38 0.76 0.76 0 0.50
    Energy 0.70 0.80 –2.39 0.01 0.47 0.73 –1.52 0.06
    Sleep 0.58 0.52 0.89 0.19 0.69 0.54 0.89 0.19
    Education & work 0.66 0.70 –0.77 0.22 0.90 0.74 1.90 0.03
    Interpersonal interactions 0.51 0.45 0.87 0.21 0.32 0.46 –0.60 0.27
    Regulating defecation 0.49 0.39 1.29 0.10 0.76 0.54 1.42 0.08
    IBD-disk total score 0.91 0.95 –3.15 0.01 0.92 0.93 –0.25 0.40
    Characteristics No. IBD-disk total score
    		 IBD daily life burden
    Mean ± SD P-value Mean ± SD P-value
    UC 464 18.39 ± 15.29 0.99 2.45 ± 2.05 0.92
    CD 82 18.38 ± 14.97 2.43 ± 1.85
    Sex 0.01 < 0.001
      Male 282 15.65 ± 13.84 2.09 ± 1.81
    Female 264 21.27 ± 16.11 2.84 ± 2.16
    Disease duration 0.65 0.99
    ≤ 2 yr 208 19.11 ± 14.68 2.46 ± 1.85
    2–5 yr 120 17.58 ± 15.02 2.43 ± 2.04
    > 5 yr 218 18.15 ± 15.89 2.44 ± 2.16
    Disease extent (UC) 0.07 0.09
    E1 56 13.96 ± 14.32 1.89 ± 1.89
    E2 331 19.02 ± 14.89 2.53 ± 2.02
    E3 77 18.90 ± 17.25 2.49 ± 2.22
    Disease location (CD) 0.87 0.57
    L1 38 17.82 ± 16.45 2.39 ± 1.91
    L2 23 18.70 ± 13.01 2.61 ± 2.15
    L3 18 20.11 ± 15.36 2.50 ± 1.38
    L4 3 12.67 ± 11.01 1.00 ± 1.00
    Disease behavior (CD) 0.19 0.29
    B1 41 15.93 ± 11.00 2.17 ± 1.53
    B2 33 19.61 ± 15.98 2.55 ± 1.87
    B3 8 25.88 ± 25.07 3.25 ± 3.01
    Disease activity (UC) < 0.001 < 0.001
    Partial Mayo Clinic score
    ≤1 173 10.39 ± 11.17 1.50 ± 1.57
    2–4 200 19.28 ± 13.54 2.48 ± 1.78
    5–7 78 29.85 ± 14.77 4.00 ± 2.15
    >7 13 42.38 ± 19.50 5.31 ± 2.59
    Disease activity (CD) 0.01 0.01
    Harvey Bradshaw Index
    <5 62 16.06 ± 13.20 1.97 ± 1.34
    5–7 17 22.18 ± 13.96 3.47 ± 2.30
    8–16 3 44.67 ± 29.67 6.00 ± 2.65
    > 16 Nil - -
    Table 1. Baseline Characteristics of the Enrolled Population

    Values are presnted as mean±standard deviation or number (%).

    Patients on combination therapies: 5-ASA+thiopurines (n=134, 24.54%); anti-TNF+thiopurines (n=5, 0.91%); vedolizumab+thiopurines (n=1, 0.18%).

    E1, proctitis; E2, left sided colitis; E3, pancolitis; 5-ASA, 5-aminosalicylates; TNF, tumour necrosis factor.

    Table 2. Correlation between Different Components of the IBD-Disk and IBD Daily Life Burden Score

    All the patients reported a score of 0, hence no correlation coefficient value reported.

    IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease.

    Table 3. Cronbach’s Coefficients (α) to Check the Internal Consistency of the Inflammatory Bowel Disease Disk

    Table 4. Correlation (Spearman’s rho) of IBD-Disk Total Score and Subscores with IBD Daily Life Burden, Stratified According to Disease Activity

    All the patients reported a score of 0, hence no correlation coefficient value reported.

    IBD, inflammatory bowel disease; NR, not reported.

    Table 5. Association between Disease Characteristics and Disability Assessed Using IBD-Disk and IBD Daily Life Burden

    IBD, inflammatory bowel disease; SD, standard deviation; UC, ulcerative colitis; CD, Crohn’s disease; E1, proctitis; E2, left sided colitis; E3, pancolitis; L1, ileal disease; L2, colonic disease; L3, ileo-colonic disease; L4, upper gastrointestinal disease; B1, non stricturing non penetrating disease; B2, stricturing disease; B3, fistulising disease.

    Table 1.

    Table 2.

    Table 3.

    Table 4.

    Table 5.

    Intest Res : Intestinal Research
    © Korean Association for the Study of Intestinal Diseases.
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