Tadakazu Hisamatsu; Mari Hayashida

doi:10.5217/ir.2017.15.3.318

Articles

Page Path: HOME > Intest Res > Volume 15(3); 2017 > Article

Focused Review: Intestinal Behçet's Disease Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease: Tadakazu Hisamatsu, Mari Hayashida; Intestinal Research 2017;15(3):318-327.
DOI: https://doi.org/10.5217/ir.2017.15.3.318
Published online: June 12, 2017

The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

Correspondence to Tadakazu Hisamatsu, The Third Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitakashi, Tokyo 181-8611, Japan. Tel: +81-422-47-5511 (ext. 5729), Fax: +81-422-71-5381, thisamatsu@ks.kyorin-u.ac.jp

• Received: January 12, 2017 • Revised: March 19, 2017 • Accepted: March 20, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

prev next

10,507 Views
88 Download
25 Web of Science
28 Crossref
34 Scopus

Full Article

Download PDF

Abstract
INTRODUCTION
MEDICAL TREATMENT
SURGICAL TREATMENT
FUTURE PERSPECTIVES
NOTES
REFERENCES

Abstract

Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Despite this, the management of intestinal BD has not been standardized. Empirical therapies including 5-aminosalicylic acid and corticosteroids have been used anecdotally to treat intestinal BD, but recent studies have provided evidence for the efficacy of anti-tumor necrosis factor α monoclonal antibodies. The development of agents targeting tumor necrosis factor α continues, it seems likely that they will change the therapeutic strategy and clinical outcomes of intestinal BD and inflammatory bowel disease. Monitoring disease activity such as endoscopic evaluation will become more important to obtain better outcomes. Here, we review current and future perspectives in the treatment and outcomes of intestinal BD.
Keywords: Intestinal Behçet's disease; Anti-TNF-α mAb; Mucosal healing

INTRODUCTION

Behçet's disease (BD) was first described in 1937 by Hulusi Behçet, a Turkish dermatologist, as a triad of recurrent aphthous stomatitis, genital aphthae, and relapsing uveitis.1 Although intestinal lesions associated with BD may cause serious complications, such as perforation, and decrease the patient's quality of life, the diagnosis and management of intestinal BD have not been standardized. Empirical therapies have been used anecdotally to treat intestinal BD. However, evidence is accumulating that anti-tumor necrosis factor α (anti-TNF-α) monoclonal antibodies (mAbs) are effective treatments for this indication. In Japan, the anti-TNF-α mAbs, adalimumab (ADA) and infliximab (IFX), are both approved for the treatment of intestinal BD. The introduction of these agents may change our therapeutic strategy and make us reconsider conventional therapies for intestinal BD.

MEDICAL TREATMENT

1. 5-Aminosalicylic Acid

Although there is little clinical evidence for its efficacy, 5-aminosalicylic acid (5-ASA) is used as an empirical therapy for intestinal BD (Table 1). Jung et al.2 retrospectively investigated the long-term clinical outcomes and predictors of clinical relapse in patients with intestinal BD receiving 5-ASA therapy. They found that for 143 patients who received 5-ASA therapy, the cumulative relapse rates at 1, 3, 5, and 10 years after remission were 8.1%, 22.6%, 31.2%, and 46.7%, respectively. In this study, younger age (<35 years), higher CRP level (≥1.5 mg/dL), and higher disease activity index for intestinal Behçet's disease (DAIBD) score (≥60) were associated with a poor response to 5-ASA therapy. Hatemi et al.3 retrospectively reviewed the treatment of 60 BD patients with gastrointestinal lesions. In 16 patients with mild disease, 5-ASA was used as initial treatment. Sonta et al.4 reported an intestinal BD patient in whom 5-ASA was effective for the treatment of esophageal ulcers. These reports suggest that 5-ASA may have clinical efficacy as induction and maintenance therapy for intestinal BD; however, further studies, including placebo-controlled trials, are necessary to confirm this. In their consensus statement, Japanese experts recommended 5-ASA for induction therapy of patients with mild to moderate intestinal BD.5

2. Corticosteroids

To date, there have been no prospective studies demonstrating the clinical efficacy of corticosteroids in intestinal BD, despite the fact that they have been used empirically for moderate to severe and refractory intestinal BD (Table 2).6 7 8 9 10 11 The Japanese consensus guideline recommends 0.5 to 1.0 mg/kg/day of prednisolone for 1 to 2 weeks as induction therapy, followed by tapering at 5 mg/wk.5 12 13 In severe cases, an intravenous high dose of prednisolone (1 mg/kg) or methylprednisolone pulse (1 g/day for 3 days) can be used.14 15 Park et al.16 reported that clinical remission and response rates to corticosteroid therapy are 46% and 43%, respectively. However, 1 year later, 35.2% of patients who achieved clinical remission showed steroid dependency and 7.4% of patients had undergone surgery. Kimura et al.17 retrospectively reviewed 34 patients with intestinal BD and compared the characteristics of patients treated with corticosteroids and/or 5-ASA (n=8) with those of patients with refractory disease who required additional immunosuppressants, anti-TNF-α mAbs, or surgery (n=12). In the refractory group, more ulcers outside the ileocecal region, more active intestinal bleeding, higher positivity for HLA-B51, higher blood CRP levels, and a higher white blood cell count at onset were observed. In particular, the presence of melena, expression of HLA-B51, or level of CRP >4 mg/dL was identified as predictive factors for refractory BD.

However, Takada and colleagues18 19 raised concerns about the use of corticosteroids in intestinal BD patients, and have also suggested that a low-residue diet may be an effective treatment.

3. Immunomodulators

Azathioprine and 6-mercaptopurine are widely used to treat patients with intestinal BD, especially in moderate to severe or refractory disease (Table 3). Jung et al.20 retrospectively reviewed all patients with intestinal BD who received thiopurine therapy. Of a total of 272 patients, 67 (24.6%) received their first course of thiopurine therapy at their center, and 39 of the 67 patients (58.2%) received thiopurines for maintenance of clinical remission. The cumulative relapse rates at 1, 2, 3, and 5 years after remission were 5.8%, 28.7%, 43.7%, and 51.7%, respectively. Japanese consensus guidelines recommend thiopurines for patients with refractory intestinal BD, such as corticosteroid-dependent or corticosteroid-resistant patients.5 Hatemi et al.3 supported azathioprine as a good choice for first-line therapy, because 65% of their patients entered remission and did not relapse during the mean follow-up of nearly 6 years. Lee et al.21 reviewed a total of 77 patients with intestinal BD who received 5-ASA (n=50, 64.9%) or thiopurine (n=27, 35.1%) therapy after surgery. The postoperative recurrence rate was lower in patients who received thiopurines than in patients treated with 5-ASA (P=0.050). The hazard ratio for recurrence was 0.636 (95% CI, 0.130–1.016; P=0.053) for postoperative thiopurine compared with that for 5-ASA. However, the rates of reoperation, readmission, and death were not significantly different between the 5-ASA and thiopurine groups. In contrast, Choi et al.22 reported that the risk of reoperation was lower for patients who received azathioprine than for those who did not. Regarding predictive factors, Park et al.23 reported that leukopenia (white blood cell count, <4,000/µL) during thiopurine therapy was associated with prolonged remission in patients with IBD and BD.

In a study of immunomodulators other than thiopurines, Iwata et al.24 reported that combination therapy with IFX and methotrexate showed efficacy for refractory intestinal BD. Matsumura et al.25 reported a case of refractory intestinal BD that was successfully treated with oral tacrolimus.

4. Thalidomide

Thalidomide has been identified as an anti-inflammatory and immunomodulatory agent because of its inhibitory effect on TNF-α. Although clinical evidence is lacking, thalidomide and its analog lenalidomide are sometimes used for the management of CD,26 27 28 and there are several studies that report the efficacy of thalidomide in intestinal BD.29 30 31 32 33 Travis et al.29 reported that thalidomide was used for maintenance therapy in patients treated with IFX. Terrin et al.30 also described a pediatric BD patient with diarrhea who was treated with thalidomide. In a report by Kari et al.,31 5 pediatric BD patients were treated with thalidomide at 1 mg/kg/wk to 1 mg/kg/day, resulting in complete remission in 3 patients and clinical response in 2. Sayarlioglu et al.32 reported a patient who required multiple surgeries due to intestinal perforations and was refractory to intense immunosuppressive therapies, including methylprednisolone and cyclophosphamide. Thalidomide (100 mg/day) was started after the third surgery, and the patient experienced no additional intestinal perforations during the follow-up period of 4 months.

Yasui et al.33 reviewed the cases of 7 patients with juvenile-onset BD with severe, recurrent intestinal involvement. Thalidomide was started at 2 mg/kg per day followed by dose adjustment according to the initial response. All 7 patients showed dramatic improvement in clinical symptoms and they successfully discontinued corticosteroid therapy. Thus, there is evidence to support the clinical efficacy of thalidomide for intestinal BD, especially pediatric BD. Nevertheless, the evidence is still insufficient, and evidence from large cohort and prospective studies is needed.

5. Anti-TNF-α mAbs

The use of anti-TNF-α mAb therapy for intestinal BD was first reported in 2001 by Hassard et al.34 They treated a patient with steroid-dependent intestinal BD with 4 doses of IFX over a 6-month period. The CDAI score, used as a clinical parameter of disease activity, decreased from 270 points before infusion to 13 points by week 2. With IFX, steroid-free remission was sustained. Endoscopic findings at 10 weeks after the first infusion showed marked improvement of intestinal lesions.34 Travis et al.29 reported the successful treatment of 2 patients having intestinal BD with IFX. Both cases were refractory to corticosteroids and other treatments, including thalidomide and cyclosporine. Within 10 days of IFX administration, the ulcers had healed and extraintestinal manifestations had improved. In these 2 patients, IFX was used as induction therapy, but not as scheduled maintenance therapy. Kram et al.35 described the successful treatment of a patient with 3 infusions of IFX at weeks 0, 2, and 6, according to a regimen of induction therapy for CD.

Since these early reports, evidence of the therapeutic utility of anti-TNF-α mAb in intestinal BD has accumulated (Table 4). Early on, IFX was the anti-TNF-α mAb most frequently used in intestinal BD,36 37 with the exception of 1 patient treated with ADA.38 In addition, IFX was used as an episodic treatment or as induction therapy (at weeks 0, 2, and 6),29 34 35 36 37 but not as a scheduled maintenance therapy. However, after the establishment of a scheduled maintenance regimen of anti-TNF-α mAb for CD (every 8 weeks), there were a number of reports of anti-TNF-α mAbs used for both induction and scheduled maintenance therapy in intestinal BD. Naganuma et al.39 reported on 6 Japanese patients with intestinal BD, all of whom were steroid dependent and refractory to other treatments, who received IFX induction therapy (5 mg/kg at 0, 2, and 6 weeks), followed by maintenance therapy every 8 weeks. Four of the 6 patients achieved and maintained remission with IFX. Iwata et al.24 assessed the short- and long-term efficacy and safety of combination therapy with IFX and methotrexate in 10 patients with refractory intestinal BD. Gastrointestinal symptoms and disease-associated complications improved within 4 weeks in all patients, and ileocecal ulcers had disappeared in 50% (5/10) and 90% (9/10) of patients at 6 and 12 months, respectively. Maruyama et al.40 described a patient with steroid-refractory intestinal BD who was successfully maintained in clinical and endoscopic remission by an infusion of IFX (5 mg/kg) every 8 weeks for 6 years. A retrospective noncontrolled review of the medical records of 28 patients with intestinal BD who received at least one dose of IFX in Korea identified clinical response rates of 75%, 64.3%, 50%, and 39.1%, and clinical remission rates of 32.1%, 28.6%, 46.2%, and 39.1%, at 2, 4, 30, and 54 weeks, respectively, after IFX infusion.42 In another study, 15 patients with active intestinal BD were treated with IFX (5 mg/kg every 8 weeks) at a single center. At week 10, 12 patients (80%) exhibited a response to IFX; 8 (53%) were in remission with no intestinal symptoms and normal CRP levels. A response to IFX was maintained in 7 of the 11 patients (64%) available at 12 months and in 4 of the 8 patients (50%) available at 24 months.43

A prospective clinical trial in Japan was started based on accumulating case reports of the efficacy of anti-TNF-α mAbs in patients with intestinal BD. This multicenter, openlabel, uncontrolled study aimed to evaluate the efficacy and safety of ADA in patients with intestinal BD who were refractory to corticosteroid and/or immunomodulator therapies.44 Twenty patients were administered 160 mg ADA at the start of the study and 80 mg 2 weeks later, followed by 40 mg every other week for 52 weeks. For some patients, the dose was increased to 80 mg every other week. The primary efficacy endpoint was the percentage of patients with a score ≤1 for gastrointestinal symptoms and endoscopic assessments at week 24. This endpoint was reached by 9 patients (45%) at week 24 of treatment, and by 12 patients (60%) by week 52. A total of 9 of 13 patients (69%) taking steroids at baseline were able to taper (n=1) or completely discontinue steroids (n=8) during the study.

Following the clinical trial of ADA, a multicenter, prospective, open-label, single-arm, phase 3 study was performed to determine the efficacy, safety, and pharmacokinetics of IFX in BD patients with serious complications, including gastrointestinal, neurological, or vascular involvement, who had shown poor response or intolerance to conventional therapy.45 IFX was administered at weeks 0, 2, and 6, and then every 8 weeks thereafter until week 46. The dose was increased to 10 IFX/kg in patients who showed inadequate responses to IFX after week 30. The percentage of complete responders (according to predefined criteria depending on the symptoms and results of ileocolonoscopy) at week 30 was defined as the primary endpoint. The percentage of complete responders was 61 (11/18) at weeks 14 and 30 and remained the same until week 54. With IFX, clinical symptoms dramatically improved and CRP levels decreased at week 2. Not only clinical symptoms, but also endoscopic findings rapidly improved. Scarring or healing of the principal ulcers was found in more than 80% of these patients after week 14. Collectively, these case reports and clinical trials provide evidence for the efficacy of anti-TNF-α mAbs in intestinal BD, at least for induction therapy. ADA and IFX efficacy was observed to be rapid by analysis of clinical, serological, and endoscopic endpoints.44 45 Although further evidence will be necessary, it is expected that both ADA and IFX will demonstrate long-term maintenance efficacy24 40 44 45 and endoscopically evident healing of ulcers.40 44 45

Anti-TNF-α mAbs have not yet been established as a postoperative therapy in patients with intestinal BD who have undergone bowel resection. Byeon et al.41 described a patient with intestinal BD who was successfully treated with IFX as rescue therapy for an unhealed anastomosis site and early recurrent ulcers after surgery.

There is no consensus about the concomitant use of immunomodulators and anti-TNF-α mAbs for intestinal BD, despite anecdotal evidence of its efficacy as induction and maintenance treatment. Even for CD, it remains unresolved whether anti-TNF-α mAbs should be used in combination with immunomodulators.46 47 48 49 50

Although one study reported the effectiveness of methotrexate plus IFX,24 another study described a patient who was successfully maintained with IFX monotherapy.40

6. Mucosal Healing as a Predictive Marker for Long-Term Prognosis

Intestinal BD is a progressive disease that causes dysfunction of the digestive tract and IBD. Postoperative disease recurrence is common, and multiple surgeries are often required in patients with refractory intestinal BD or CD. Since clinical symptoms and the clinical activity index of IBD are often subjective, discrepancies between clinical symptoms and endoscopic findings are often observed. To date, endoscopic findings have been considered the gold standard objective parameter for evaluation of IBD activity. Mucosal healing, defined as endoscopic remission, has become the goal of IBD treatment. Many retrospective studies have indicated that mucosal healing may predict better long-term prognosis, including maintenance of clinical remission, reduced risk of surgery, and reduced risk for the development of colon cancer.51 Although there is currently insufficient evidence, the concept of “mucosal healing” may also be applicable to the management of intestinal BD. Lee et al.52 reported that the discrepancy between the clinical activity index and endoscopic findings is observed not only in IBD but also in intestinal BD. Yim et al.53 retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months of clinical remission. At the time of clinical remission, 57 patients (71.3%) had active ulcers and 23 patients (28.7%) achieved mucosal healing. At the follow-up point, 39 patients (68.4%) in the active ulcer group but only 7 (30.4%) in the mucosal healing group experienced recurrence. The cumulative recurrence rate was significantly higher in the active ulcer group than in the mucosal healing group (P<0.001), suggesting that mucosal healing could be a predictive factor for long-term prognosis in intestinal BD. Several case reports and 2 clinical trials (ADA and IFX) have shown that anti-TNF-α mAbs can induce and maintain mucosal healing in intestinal BD patients.40 44 45 Further prospective analyses will be necessary to prove that achievement of mucosal healing improves long-term prognosis in terms of a reduced clinical relapse rate and risk of surgery.

SURGICAL TREATMENT

1. Risk of Surgery and Prognosis

About 3% to 16% of patients with BD have gastrointestinal tract involvement.12 The natural history of intestinal BD has not been clearly delineated and it is difficult to predict which patients will experience a poor clinical course. In a retrospective review of 20 patients, Naganuma et al.54 reported that the presence of ocular and ileal lesions was a risk for surgery. Jung et al.55 evaluated the clinical course of 130 intestinal BD patients during the first 5 years after diagnosis, and found that the majority of patients (74.6%) achieved remission or mild clinical activity at 5 years, whereas 16.2% had multiple relapses or chronic symptoms. Furthermore, the clinical course over the first year after diagnosis influenced the course in subsequent years. Patients in the severe clinical course group were younger, had lower albumin levels, and had higher ESR, CRP levels, and DAIBD scores than patients in the mild clinical course group.

Despite the evident benefits of medical therapy, intestinal BD patients sometimes require surgery and may experience postoperative disease recurrence. Intestinal BD is associated with complications such as intestinal perforation, bleeding, and abscess, and intestinal involvement is therefore a poor prognostic indicator for BD patients. Perforation and massive gastrointestinal bleeding are absolute indications for surgery, and abdominal abscess, fistula, and stricture should be considered as possible indications. Other surgery candidates are intestinal BD patients who are refractory to medical treatment, including corticosteroid and anti-TNF-α mAbs. However, surgery should be carefully considered in these patients because of the risk of postoperative recurrence. Thus, intestinal BD should be considered a progressive disorder, at least in a subpopulation of patients. Chung et al.56 performed a retrospective review of 93 patients with intestinal BD who received medical therapy, and found cumulative recurrence rates of 24.9% at 2 years and 43.0% at 5 years. The presence of gastrointestinal symptoms at the initial presentation was a risk for recurrence. Patients with volcano-type and deep intestinal ulcers, and those who failed to achieve complete remission during the initial treatment, also had a risk of recurrence. Cumulative rates for surgery were 6.7% at 2 years and 15.1% at 5 years. The typical type of ulcer was the only predictive factor for the likelihood of surgery. Moon et al.57 reviewed 129 patients with intestinal BD. Among them, 33 patients had intestinal perforations and all underwent emergent or elective laparotomy. Younger age (≤25 years) at diagnosis, history of prior laparotomy, and volcano-shaped intestinal ulcers were identified as independent risk factors for free bowel perforation in these patients.

One concern about surgical treatment in intestinal BD patients is the risk for postoperative disease recurrence requiring repeat surgery. Iida et al.58 reported that postoperative recurrence of intestinal ulcers was observed in 7 of 9 patients who had undergone a total of 15 operations. Jung et al.59 reported that 42 (58.3%) of 72 Korean patients who had undergone surgery experienced postoperative recurrence, with 22 (30.6%) requiring reoperation. The cumulative 2- and 5-year recurrence rates after surgery were 29.2% and 47.2%, respectively.

2. Postoperative Treatment

To date, a standard postoperative treatment strategy for intestinal BD patients has not been established. The clinical benefit of postoperative thiopurine therapy is controversial. Lee et al.21 reviewed the outcomes of 77 patients with intestinal BD and found lower postoperative recurrence rates in patients who were treated postoperatively with thiopurines, compared with those receiving 5-ASA. However, there were no significant differences in the rates of reoperation, readmission, or death between the 2 groups. In contrast, Choi et al.22 reported that patients who received azathioprine postoperatively showed better clinical courses than those who did not. Thalidomide was also used as a postoperative therapy in a patient who required multiple surgeries.32 To date, there are no reports reviewing the efficacy of postoperative anti-TNF-α mAbs therapy in intestinal BD patients.

FUTURE PERSPECTIVES

Accumulating clinical evidence supports the efficacy of anti-TNF-α mAbs for intestinal BD and may change the therapeutic strategy for this disease. Most importantly, the natural history of refractory patients and their risk factors should be identified. The importance of endoscopic remission for monitoring disease activity has not been fully accepted in the management of intestinal BD, as it has for IBD. In addition, further clinical studies are necessary to evaluate immunomodulators and anti-TNF-α mAbs as maintenance therapy for intestinal BD. Postoperative management of intestinal BD also needs to be standardized, both to decrease the risk of repeat surgery and to improve the quality of life for postoperative patients.

NOTES

Financial support: This work was supported in part by grants from the Japan Sciences Research Grant for Research on Intractable Diseases (Japanese Inflammatory Bowel Disease Research Group and Behçet's Disease Research Committee) affiliated with the Japan Ministry of Health, Labour and Welfare.

Conflict of interest: None.

REFERENCES

1. Behçet H. Über rezidivierende, aphthöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 1937;105:1152–1157.
2. Jung YS, Hong SP, Kim TI, Kim WH, Cheon JH. Long-term clinical outcomes and factors predictive of relapse after 5-aminosalicylate or sulfasalazine therapy in patients with intestinal Behcet disease. J Clin Gastroenterol 2012;46:e38–e45.PMID: 22298088.Article PubMed
3. Hatemi I, Esatoglu SN, Hatemi G, Erzin Y, Yazici H, Celik AF. Characteristics, treatment, and long-term outcome of gastrointestinal involvement in Behcet's syndrome: a strobe-compliant observational study from a dedicated multidisciplinary center. Medicine (Baltimore) 2016;95:e3348PMID: 27100417.Article PubMed PMC
4. Sonta T, Araki Y, Koubokawa M, et al. The beneficial effect of mesalazine on esophageal ulcers in intestinal Behcet's disease. J Clin Gastroenterol 2000;30:195–199.PMID: 10730926.Article PubMed
5. Hisamatsu T, Ueno F, Matsumoto T, et al. The 2nd edition of consensus statements for the diagnosis and management of intestinal Behçet's disease: indication of anti-TNFalpha monoclonal antibodies. J Gastroenterol 2014;49:156–162.PMID: 23955155.Article PubMed
6. Nakase H, Okazaki K, Kawanami C, et al. Therapeutic effects on intestinal Behçet's disease of an intravenous drug delivery system using dexamethasone incorporated in lipid emulsion. J Gastroenterol Hepatol 2001;16:1306–1308.PMID: 11903753.Article PubMed
7. Toda K, Shiratori Y, Yasuda M, et al. Therapeutic effect of intraarterial prednisolone injection in severe intestinal Behçet's disease. J Gastroenterol 2002;37:844–848.PMID: 12424569.Article PubMed
8. Yasuo M, Miyabayashi H, Okano T, Aoki H, Ichikawa K, Hirose Y. Successful treatment with corticosteroid in a case of Behçet's syndrome with multiple esophageal ulcerations. Intern Med 2003;42:696–699.PMID: 12924494.Article PubMed
9. Cheon JH, Kim WH. An update on the diagnosis, treatment, and prognosis of intestinal Behçet's disease. Curr Opin Rheumatol 2015;27:24–31.PMID: 25405821.Article PubMed
10. Skef W, Hamilton MJ, Arayssi T. Gastrointestinal Behçet's disease: a review. World J Gastroenterol 2015;21:3801–3812.PMID: 25852265.Article PubMed PMC
11. Hisamatsu T, Naganuma M, Matsuoka K, Kanai T. Diagnosis and management of intestinal Behçet's disease. Clin J Gastroenterol 2014;7:205–212.PMID: 24883128.Article PubMed PMC
12. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999;341:1284–1291.PMID: 10528040.Article PubMed
13. Kobayashi K, Ueno F, Bito S, et al. Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach. J Gastroenterol 2007;42:737–745.PMID: 17876543.Article PubMed
14. Grigg EL, Kane S, Katz S. Mimicry and deception in inflammatory bowel disease and intestinal Behçet disease. Gastroenterol Hepatol (N Y) 2012;8:103–112.PMID: 22485077.PubMed PMC
15. Saleh Z, Arayssi T. Update on the therapy of Behçet disease. Ther Adv Chronic Dis 2014;5:112–134.PMID: 24790727.Article PubMed PMC
16. Park JJ, Cheon JH, Moon CM, et al. Long-term clinical outcomes after the first course of corticosteroid therapy in patients with moderate to severe intestinal Behget's disease. Gastroenterology 2010;138:S698–S699.
17. Kimura Y, Asako K, Kikuchi H, Kono H. Characteristics of patients with intestinal Behçet's disease requiring treatment with immunosuppressants or anti-TNFalpha antibody. Mod Rheumatol 2016;26:132–137.PMID: 26025434.Article PubMed
18. Takada Y, Saigenji K. Is intestinal Behçet's disease in fact an enterocolitis or an ulcer disease, and is steroid treatment useful or harmful? J Gastroenterol 2003;38:1015–1016.PMID: 14614614.Article PubMed
19. Takada Y, Fujita Y, Igarashi M, et al. Intestinal Behçet's disease: pathognomonic changes in intramucosal lymphoid tissues and effect of a “rest cure” on intestinal lesions. J Gastroenterol 1997;32:598–604.PMID: 9349984.Article PubMed
20. Jung YS, Cheon JH, Hong SP, Kim TI, Kim WH. Clinical outcomes and prognostic factors for thiopurine maintenance therapy in patients with intestinal Behcet's disease. Inflamm Bowel Dis 2012;18:750–757.PMID: 21618352.Article PubMed
21. Lee HW, Cheon JH, Lee HJ, et al. Postoperative effects of thiopurines in patients with intestinal Behçet's disease. Dig Dis Sci 2015;60:3721–3727.PMID: 26199149.Article PubMed
22. Choi IJ, Kim JS, Cha SD, et al. Long-term clinical course and prognostic factors in intestinal Behçet's disease. Dis Colon Rectum 2000;43:692–700.PMID: 10826433.Article PubMed
23. Park MS, Kim DH, Kim DH, et al. Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance. Dig Dis Sci 2015;60:195–204.PMID: 25239495.Article PubMed
24. Iwata S, Saito K, Yamaoka K, et al. Efficacy of combination therapy of anti-TNF-alpha antibody infliximab and methotrexate in refractory entero-Behçet's disease. Mod Rheumatol 2011;21:184–191.PMID: 21052764.Article PubMed
25. Matsumura K, Nakase H, Chiba T. Efficacy of oral tacrolimus on intestinal Behcet's disease. Inflamm Bowel Dis 2010;16:188–189.PMID: 19504615.Article PubMed
26. Felipez LM, Gokhale R, Tierney MP, Kirschner BS. Thalidomide use and outcomes in pediatric patients with Crohn disease refractory to infliximab and adalimumab. J Pediatr Gastroenterol Nutr 2012;54:28–33.PMID: 21681114.Article PubMed
27. Akobeng AK, Stokkers PC. Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2009;(2): CD007351PMID: 10.1002/14651858.CD007351.pub2. PMID: 19370685.Article PubMed PMC
28. Srinivasan R, Akobeng AK. Thalidomide and thalidomide analogues for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2009;(2): CD007350PMID: 10.1002/14651858.CD007350.pub2. PMID: 19370684.Article PubMed
29. Travis SP, Czajkowski M, McGovern DP, Watson RG, Bell AL. Treatment of intestinal Behçet's syndrome with chimeric tumour necrosis factor alpha antibody. Gut 2001;49:725–728.PMID: 11600479.Article PubMed PMC
30. Terrin G, Borrelli O, Di Nardo G, Pacchiarotti C, Cucchiara S. A child with aphthae and diarrhoea. Lancet 2002;359:316PMID: 11830199.Article PubMed
31. Kari JA, Shah V, Dillon MJ. Behçet's disease in UK children: clinical features and treatment including thalidomide. Rheumatology (Oxford) 2001;40:933–938.PMID: 11511764.Article PubMed PDF
32. Sayarlioglu M, Kotan MC, Topcu N, Bayram I, Arslanturk H, Gul A. Treatment of recurrent perforating intestinal ulcers with thalidomide in Behçet's disease. Ann Pharmacother 2004;38:808–811.PMID: 15010523.Article PubMed
33. Yasui K, Uchida N, Akazawa Y, et al. Thalidomide for treatment of intestinal involvement of juvenile-onset Behçet disease. Inflamm Bowel Dis 2008;14:396–400.PMID: 17973303.Article PubMed
34. Hassard PV, Binder SW, Nelson V, Vasiliauskas EA. Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal Behçet's disease: a case report. Gastroenterology 2001;120:995–999.PMID: 11231954.Article PubMed
35. Kram MT, May LD, Goodman S, Molinas S. Behçet's ileocolitis: successful treatment with tumor necrosis factor-alpha antibody (infliximab) therapy: report of a case. Dis Colon Rectum 2003;46:118–121.PMID: 12544532.Article PubMed
36. Lee JH, Kim TN, Choi ST, et al. Remission of intestinal Behçet's disease treated with anti-tumor necrosis factor alpha monoclonal antibody (Infliximab). Korean J Intern Med 2007;22:24–27.PMID: 17427642.Article PubMed PMC
37. Ugras M, Ertem D, Celikel C, Pehlivanoglu E. Infliximab as an alternative treatment for Behçet disease when other therapies fail. J Pediatr Gastroenterol Nutr 2008;46:212–215.PMID: 18223383.Article PubMed
38. Ariyachaipanich A, Berkelhammer C, Nicola H. Intestinal Behçet's disease: maintenance of remission with adalimumab monotherapy. Inflamm Bowel Dis 2009;15:1769–1771.PMID: 19177427.Article PubMed
39. Naganuma M, Sakuraba A, Hisamatsu T, et al. Efficacy of infliximab for induction and maintenance of remission in intestinal Behçet's disease. Inflamm Bowel Dis 2008;14:1259–1264.PMID: 18393375.Article PubMed
40. Maruyama Y, Hisamatsu T, Matsuoka K, et al. A case of intestinal Behçet's disease treated with infliximab monotherapy who successfully maintained clinical remission and complete mucosal healing for six years. Intern Med 2012;51:2125–2129.PMID: 22892489.Article PubMed
41. Byeon JS, Choi EK, Heo NY, et al. Antitumor necrosis factoralpha therapy for early postoperative recurrence of gastrointestinal Behçet's disease: report of a case. Dis Colon Rectum 2007;50:672–676.PMID: 17216141.Article PubMed
42. Lee JH, Cheon JH, Jeon SW, et al. Efficacy of infliximab in intestinal Behçet's disease: a Korean multicenter retrospective study. Inflamm Bowel Dis 2013;19:1833–1838.PMID: 23702810.PubMed
43. Kinoshita H, Kunisaki R, Yamamoto H, et al. Efficacy of infliximab in patients with intestinal Behçet's disease refractory to conventional medication. Intern Med 2013;52:1855–1862.PMID: 23994973.Article PubMed
44. Tanida S, Inoue N, Kobayashi K, et al. Adalimumab for the treatment of Japanese patients with intestinal Behçet's disease. Clin Gastroenterol Hepatol 2015;13:940–948.e3.PMID: 25245624.Article PubMed
45. Hibi T, Hirohata S, Kikuchi H, et al. Infliximab therapy for intestinal, neurological, and vascular involvement in Behcet disease: efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label, single-arm phase 3 study. Medicine (Baltimore) 2016;95:e3863PMID: 10.1097/MD.0000000000003863. PMID: 27310969.Article PubMed PMC
46. Van Assche G, Magdelaine-Beuzelin C, D'Haens G, et al. Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial. Gastroenterology 2008;134:1861–1868.PMID: 18440315.Article PubMed
47. Schnitzler F, Fidder H, Ferrante M, et al. Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort. Gut 2009;58:492–500.PMID: 18832518.Article PubMed
48. Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010;362:1383–1395.PMID: 20393175.Article PubMed
49. Dassopoulos T, Sultan S, Falck-Ytter YT, Inadomi JM, Hanauer SB. American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-alpha biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease. Gastroenterology 2013;145:1464–1478.1478.e1–1478.e5.PMID: 24267475.Article PubMed
50. Matsumoto T, Motoya S, Watanabe K, et al. Adalimumab monotherapy and a combination with azathioprine for Crohn's disease: a prospective, randomized trial. J Crohns Colitis 2016;10:1259–1266.PMID: 27566367.Article PubMed PDF
51. Zallot C, Peyrin-Biroulet L. Deep remission in inflammatory bowel disease: looking beyond symptoms. Curr Gastroenterol Rep 2013;15:315PMID: 23354742.Article PubMed
52. Lee HJ, Kim YN, Jang HW, et al. Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease. World J Gastroenterol 2012;18:5771–5778.PMID: 23155319.Article PubMed PMC
53. Yim SM, Kim DH, Lee HJ, et al. Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease. Dig Dis Sci 2014;59:2529–2535.PMID: 24838499.Article PubMed
54. Naganuma M, Iwao Y, Inoue N, et al. Analysis of clinical course and long-term prognosis of surgical and nonsurgical patients with intestinal Behçet's disease. Am J Gastroenterol 2000;95:2848–2851.PMID: 11051358.Article PubMed
55. Jung YS, Cheon JH, Park SJ, Hong SP, Kim TI, Kim WH. Clinical course of intestinal Behcet's disease during the first five years. Dig Dis Sci 2013;58:496–503.PMID: 22899244.Article PubMed
56. Chung MJ, Cheon JH, Kim SU, et al. Response rates to medical treatments and long-term clinical outcomes of nonsurgical patients with intestinal Behçet disease. J Clin Gastroenterol 2010;44:e116–e122.PMID: 10.1097/MCG.0b013e3181c8a50f. PMID: 20054283.Article PubMed
57. Moon CM, Cheon JH, Shin JK, et al. Prediction of free bowel perforation in patients with intestinal Behçet's disease using clinical and colonoscopic findings. Dig Dis Sci 2010;55:2904–2911.PMID: 20094787.Article PubMed
58. Iida M, Kobayashi H, Matsumoto T, et al. Postoperative recurrence in patients with intestinal Behçet's disease. Dis Colon Rectum 1994;37:16–21.PMID: 8287741.Article PubMed
59. Jung YS, Yoon JY, Lee JH, et al. Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcet's disease. Inflamm Bowel Dis 2011;17:1594–1602.PMID: 21674717.Article PubMed

Table 1

5-Aminosalicylic Acid Treatment

Author (year)	Level of published evidence	No. of patients	Outcome
Sonta et al. (2000)4	Case report	1	Mesalazine demonstrated clinical efficacy on esophageal ulcers
Jung et al. (2012)2	Retrospective (single tertiary academic center)	143	• Clinical relapse: 32.2% (relapse rates: 1 yr, 8.1%; 3 yr, 22.6%; 5 yr, 31.2%; 10 yr, 46.7%)
Jung et al. (2012)2	Retrospective (single tertiary academic center)	143	• Poor response to 5-ASA therapy: younger age <35 yr; CRP >1.5 mg/dL; DAIBD score ≥60
Hisamatsu et al. (2014)5	Japanese consensus statements	-	The optimal dose of 5-ASA for adult patients, 2.25–3.00 g/day. Sulfasalazine is also used, the optimal dose is 3–4 g/day.
Hatemi et al. (2016)3	Retrospective (multidisciplinary center)	16	10 of 16 patients (62.5%) achieved remission and did not relapse during the 89.3±64.5 mo

5-ASA, 5-aminosalicylic acid; DAIBD, disease activity index for intestinal Behçet's disease.

Table 2

Corticosteroid Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Nakase et al. (2001)6	Case report	1	PSL 40 mg+intravenous dexamethasone 2.5 mg every 2 wk	After 4 wk, the endoscopic findings of cecal ulcer revealed healing
Toda et al. (2002)7	Case report	1	PSL 40 mg+20 mg of prednisolones injections into the superior and inferior mesenteric arteries	Multiple healing ulcers, but no open ulcers, were observed between the rectum and transverse colon 12 day after intraarterial prednisolone injection.
Yasuo et al. (2003)8	Case report	1	PSL 0.5 mg/kg	The endoscopic findings of esophageal ulcer revealed healing.
Park et al. (2010)16	Retrospective	54	The median dosage of corticosteroid, 0.58 mg/kg (0.39–1.20 mg/kg)
Hisamatsu et al. (2014)5	Japanese consensus statements	-	Weight-based approach of 0.5–1.0 mg/kg per day of prednisolone for 1–2 wk followed by a taper of 5 mg weekly until discontinuation.	-
Saleh and Arayssi (2014)15	Review	-	1 g intravenous methylprednisolone infusions daily for 3 day, followed by 1 mg/kg/day prednisolone tapered slowly	-

PSL, prednisolone.

Table 3

Immunomodulator Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Matsumura et al. (2010)25	Case report	1	• Tacrolimus serum level, 10–15 ng/mL • After 5 mo: 5–10 ng/mL	• Oral tacrolimus was effective for refractory intestinal BD. • Colonoscopy 33 mo after starting tacrolimus revealed complete disappearance of the ascending colon ulceration.
Jung et al. (2012)20	Retrospective	39	• AZA, 2.0–2.5 mg/kg (starting dose, 25 mg or 50 mg/day) • 6-MP, 1.0–1.5 mg/kg (starting dose, 0.5 mg/kg)	• 39 of the 67 patients (58.2%) constantly received thiopurines for maintaining medically or surgically induced remission. • Relapse rates at 1, 2, 3, and 5 yr after remission were 5.8%, 28.7%, 43.7%, and 51.7%.
Hisamatsu et al. (2014)5	Japanese consensus statements	-	AZA, 25–50 mg/day	Japanese consensus statements (the 2nd) recommended thiopurines for refractory intestinal BD such as corticosteroid-dependent or -resistant patients.
Lee et al. (2015)21	Retrospective	77	After surgery: Thiopurine (n=27) • AZA, 2.0–2.5 mg/kg 6-MP, 1.0–1.5 mg/kg 5-ASA (n=50) • 5-ASA, 3–4 g/day	• Postoperative recurrence rate was lower in patients who received postoperative thiopurines (P=0.050). • The hazard ratio for recurrence was 0.636 (95% CI, 0.130–1.016; P=0.053) for postoperative thiopurine use compared with postoperative 5-ASA.
Park et al. (2015)23	Retrospective	83	• AZA, 2.0–2.5 mg/kg (6-MP dose was converted to equivalent AZA) • Starting AZA/6-MP dose, 1.0 mg/kg/day	Leukopenia (WBC count <4,000/µL) during thiopurine maintenance therapy was associated with prolonged remission in patients with IBD and BD during 6 yr.
Hatemi et al. (2016)3	Retrospective	37	AZA, 2.0–2.5 mg/kg/day	65% of patients obtained remission and did not relapse during a mean follow-up of 68.6±43.6 mo.

BD, Behçet's disease; AZA, azathioprine; 6-MP, 6-mercaptopurine; 5-ASA, 5-aminosalicylic acid; WBC, white blood cell.

Table 4

Anti-Tumor Necrosis Factor α Monoclonal Antibody Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Hassard et al. (2001)34	Case report	1	IFX, 4 doses during a 6-mo period	• CDAI decreased from 270 to 13 points by wk 2 and steroid-free remission was sustained. • Endoscopic finding at 10 wk after the first infusion was markedly improved.
Travis et al. (2001)29	Case report	2	• IFX, 3 mg/kg (wk 0, 8) • 5 mg/kg (wk 0, 12, 24)	• Within 10 day the ulcers healed and extraintestinal manifestations were improved. • IFX was used as induction therapy.
Kram et al. (2003)35	Case report	1	IFX, 5 mg/kg (wk 0, 2, 6) according to the regimen of induction therapy for CD	After 2 IFX infusion, ESR and CRP normalized. Colon ulcers revealed healing.
Lee et al. (2007)36	Case report	1	IFX, 5 mg/kg (wk 0, 4)	After 2 IFX infusion, symptoms and laboratory tests, colon ulcers revealed decreased.
Byeon et al. (2007)41	Case report	1	IFX, 5 mg/kg (rescue therapy after a distal ileocecectomy)	IFX was an effective rescue therapy of an unhealed anastomosis site and early recurrent ulcers after surgery.
Ugras et al. (2008)37	Case report	1	IFX 5 mg/kg (wk 0, 2, 6)	After 2 IFX infusion, clinical symptoms improved.
Naganuma et al. (2008)39	Case report	6	IFX induction therapy (5 mg/kg at wk 0, 2, 6), followed by maintenance therapy every 8 wk	4 of 6 patients achieved and maintained remission.
Maruyama et al. (2012)40	Case report	1	IFX induction therapy (5 mg/kg at 0, 2, and 6 wk), followed by maintenance therapy every 8 wk	Successfully maintained in clinical and endoscopic remission by every 8-wk infusion of IFX for 6 yr.
Iwata et al. (2011)24	Retrospective	10	MTX+IFX, 3–5 mg/kg (wk 0, 2, 6 and followed by every 8 until 24 wk)	• Gastrointestinal symptoms and disease-associated complications were improved within 4 wk in all patients. • Ileocecal ulcers were disappeared in 50% patients at 6 mo and 90% patients at 12 mo.
Lee et al. (2013)42	Retrospective	28	IFX, 5 mg/kg (wk 0, 2, 4, 30, 54)	• The clinical response rates at 2, 4, 30, and 54 wk were 75%, 64.3%, 50%, and 39.1%, respectively, with clinical remission rates of 32.1%, 28.6%, 46.2%, and 391. %, respectively. • Older age at diagnosis (≥40 yr), female sex, a longer disease duration (≥5 yr), concomitant immunomodulator use, and achievement of remission at 4 wk found to be predictive factors of sustained response.
Kinoshita et al. (2013)43	Retrospective	15	IFX induction therapy (5 mg/kg at 0, 2, and 6 wk), followed by maintenance therapy every 8 wk	• At wk 10, 12 patients (80%) exhibited a response to IFX, with 8 (53%) in remission with no intestinal symptoms and normal CRP levels. • A response to IFX was maintained in 7 of the 11 patients (64%) available at 12 mo and in 4 of the 8 patients (50%) available at 24 mo.
Tanida et al. (2015)44	A multicenter, openlabel, uncontrolled study	20	ADA, 160 mg (wk 0), 80 mg (wk 2), 40 mg (wk 4), followed by 40 mg every other week for 52 wk (n=6) and 11 patients followed by 80 mg every other week for 52 wk.	• The primary efficacy end point was the percentage of patients with scores of 1 or lower for gastrointestinal symptom and endoscopic assessments at wk 24. • 9 patients (45%) had gastrointestinal symptom and endoscopic assessment scores of 1 or lower at wk 24 of treatment. • 12 patients (60%) had these scores by wk 52. • A total of 9 of 13 patients (69%) taking steroids at baseline were able to taper (n=1) or completely discontinue steroids (n=8) during the study.
Hibi et al. (2016)45	A multicenter, prospective, openlabel, single-arm phase 3 study	18 (intestinal BD, 11; ANB, 2; CPNB,1; VBD, 4)	• IFX, 5 mg/kg (wk 0, 2, and 6 and every 8 wk thereafter until wk 46) • IFX, 10 mg/kg (patients who showed inadequate responses after wk 30)	• The percentage of complete responders was 61% (11/18) at both wk 14 and 30 and remained the same until wk 54. • Intestinal BD patients showed improvement in clinical symptoms along with decrease in CRP levels after wk 2. • Scarring or healing of the principal ulcers was found in more than 80% of these patients after wk 14.

IFX, infliximab; MTX, methotrexate; ADA, adalimumab; BD, Behçet's disease; ANB, acute neurological BD; CPNB, chronic progressive neurological BD; VBD, vascular BD.

Figure & Data

REFERENCES

Citations

Citations to this article as recorded by

Management of Severe Behçet’s Disease
Kerem Abacar, Haner Direskeneli, Fatma Alibaz-Oner
Current Rheumatology Reports.2026;[Epub] CrossRef
Behçet’s disease: incidence, prevalence, and real-word data on the use of biologic agents in Japan
Tadakazu Hisamatsu, Makoto Naganuma, Philippe Pinton, Mitsuhiro Takeno
Journal of Gastroenterology.2025; 60(3): 294. CrossRef
Upper Gastrointestinal Involvement in Behcet’s Disease
Hogyung Jun, Hyun Joo Song, Ji Hwan Mun, Heung Up Kim
The Korean Journal of Gastroenterology.2025; 85(2): 170. CrossRef
Long-Term Outcomes and Clinical Factors Associated with Conventional Therapy Failure in Intestinal Behçet’s Disease: A Retrospective Cohort Study in Japan
Keita Murakami, Junya Arai, Sozaburo Ihara, Yumi Tsuchida, Haruka Tsuchiya, Mayo Tsuboi, Ken Kurokawa, Nobumi Suzuki, Hiroto Kinoshita, Yoku Hayakawa, Keishi Fujio, Mitsuhiro Fujishiro
Digestion.2025; : 1. CrossRef
Impact of age at diagnosis on long‐term prognosis in patients with intestinal Behçet's disease
Ji Young Chang, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon, Jihye Park
Journal of Gastroenterology and Hepatology.2024; 39(3): 519. CrossRef
Behçet's syndrome
Giacomo Emmi, Alessandra Bettiol, Gülen Hatemi, Domenico Prisco
The Lancet.2024; 403(10431): 1093. CrossRef
Neither hepatic steatosis nor fibrosis is associated with clinical outcomes in patients with intestinal Behçet’s disease
Hye Kyung Hyun, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
European Journal of Gastroenterology & Hepatology.2024; 36(4): 445. CrossRef
Optimal Treatment Approaches to Intestinal Behçet's Disease Complicated by Myelodysplastic Syndrome: The KASID and KSBD Multicenter Study
Jung-Bin Park, So Jung Han, Seung Bum Lee, Dong Hyun Kim, Jae Hee Cheon, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Soo Jung Park, Sang Hyoung Park
Yonsei Medical Journal.2024; 65(5): 265. CrossRef
Behçet disease: epidemiology, classification criteria and treatment modalities
Alia Fazaa, Yasmine Makhlouf, Faiza Ben Massoud, Saoussen Miladi, Hiba Boussaa, Kmar Ouenniche, Leila Souebni, Selma Kassab, Selma Chekili, Kawther Ben Abdelghani, Ahmed Laatar
Expert Review of Clinical Immunology.2024; 20(12): 1437. CrossRef
Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-Tumor Necrosis Factor-Alpha Therapy
So Jung Han, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Yonsei Medical Journal.2023; 64(2): 111. CrossRef
Possible Association of Mutations in the MEFV Gene with the Intestinal Phenotype of Behçet’s Disease and Refractoriness to Treatment
Yoki Furuta, Ryosuke Gushima, Hideaki Naoe, Munenori Honda, Yuiko Tsuruta, Katsuya Nagaoka, Takehisa Watanabe, Masakuni Tateyama, Nahoko Fujimoto, Shinya Hirata, Eiko Miyagawa, Komei Sakata, Yumiko Mizuhashi, Mikako Iwakura, Masayuki Murai, Masao Matsuoka
Journal of Clinical Medicine.2023; 12(9): 3131. CrossRef
Immune‐mediated inflammatory diseases of the gastrointestinal tract: Beyond Crohn's disease and ulcerative colitis
Sudheer K Vuyyuru, Saurabh Kedia, Pabitra Sahu, Vineet Ahuja
JGH Open.2022; 6(2): 100. CrossRef
Mucosal healing in intestinal Behçet's disease: A systematic review and meta‐analysis
Liang Gong, Yue Lun Zhang, Lu Xi Sun, Guo Rong Chen, Dong Wu
Journal of Digestive Diseases.2021; 22(2): 83. CrossRef
Experimental Therapeutic Solutions for Behcet’s Disease
Burçin Cansu Bozca, Erkan Alpsoy
Journal of Experimental Pharmacology.2021; Volume 13: 127. CrossRef
Treatment of Behçet's Disease: An Algorithmic Multidisciplinary Approach
Erkan Alpsoy, Pietro Leccese, Giacomo Emmi, Shigeaki Ohno
Frontiers in Medicine.2021;[Epub] CrossRef
Behçet Disease: An Update for Dermatologists
Erkan Alpsoy, Burcin Cansu Bozca, Asli Bilgic
American Journal of Clinical Dermatology.2021; 22(4): 477. CrossRef
Long-term safety and effectiveness of adalimumab in 462 patients with intestinal Behçet’s disease: results from a large real-world observational study
Yasuo Suzuki, Takashi Hagiwara, Mariko Kobayashi, Kazuo Morita, Tomoyo Shimamoto, Toshifumi Hibi
Intestinal Research.2021; 19(3): 301. CrossRef
Is fasting beneficial for hospitalized patients with inflammatory bowel diseases?
Yong Eun Park, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim, Jung Nam Kim, Na Rae Lee, Jae Hee Cheon
Intestinal Research.2020; 18(1): 85. CrossRef
Elevated fecal calprotectin and lactoferrin associated with small intestinal lesions in patients with Behçet disease
Mari Hayashida, Jun Miyoshi, Tatsuya Mitsui, Miki Miura, Daisuke Saito, Akihito Sakuraba, Soko Kawashima, Noriko Ikegaya, Kazuhito Fukuoka, Miho Karube, Yoshinori Komagata, Shinya Kaname, Annabelle A Okada, Shunji Fujimori, Minoru Matsuura, Tadakazu Hisam
Journal of Gastroenterology and Hepatology.2020; 35(8): 1340. CrossRef
Successful combination therapy using adalimumab and 5-aminosalicylic acid for a resistant case of intestinal Behçet’s disease
H. J. Kim, K.‑t. Kim, S.-G. Lee, Y. Kim
Zeitschrift für Rheumatologie.2020; 79(7): 702. CrossRef
Update on the treatment of Behçet’s syndrome
Sinem Nihal Esatoglu, Gulen Hatemi
Internal and Emergency Medicine.2019; 14(5): 661. CrossRef
Behсet's disease: intestinal damage
R. G. Goloeva, Z. S. Alekberova
Rheumatology Science and Practice.2019; 56(6): 767. CrossRef
Intestinal manifestations of Behçet's disease
R G Goloeva, Z S Alekberova, T A Lisitsyna, E A Stepanova, L P Orlova
Terapevticheskii arkhiv.2019; 91(5): 111. CrossRef
The outcomes and risk factors of early readmission in patients with intestinal Behçet’s disease
Yong Eun Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
Clinical Rheumatology.2018; 37(7): 1913. CrossRef
Cancer Risk in Patients with Intestinal Behçet’s Disease: A Nationwide Population-Based Study
Minkyung Han, Yoon Suk Jung, Won Ho Kim, Jae Hee Cheon, Sohee Park
Gut and Liver.2018; 12(4): 433. CrossRef
Updated treatment strategies for intestinal Behçet’s disease
Yong Eun Park, Jae Hee Cheon
The Korean Journal of Internal Medicine.2018; 33(1): 1. CrossRef
Small Bowel Lesions Mimicking Crohn’s Disease
David B. Sachar
Current Gastroenterology Reports.2018;[Epub] CrossRef
Anti-Tumor Necrosis Factor Therapy in Intestinal Beh Ccedil;et rsquo;s Disease
Jihye Park, Jae Hee Cheon
Gut and Liver.2018; 12(6): 623. CrossRef

PubReader
ePub Link

Cite

CITE: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease

Intest Res. 2017;15(3):318-327. Published online June 12, 2017

DOI: https://doi.org/10.5217/ir.2017.15.3.318

XML Download

Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease

Table 1

5-Aminosalicylic Acid Treatment

Author (year)	Level of published evidence	No. of patients	Outcome
Sonta et al. (2000)4	Case report	1	Mesalazine demonstrated clinical efficacy on esophageal ulcers
Jung et al. (2012)2	Retrospective (single tertiary academic center)	143	• Clinical relapse: 32.2% (relapse rates: 1 yr, 8.1%; 3 yr, 22.6%; 5 yr, 31.2%; 10 yr, 46.7%)
Jung et al. (2012)2	Retrospective (single tertiary academic center)	143	• Poor response to 5-ASA therapy: younger age <35 yr; CRP >1.5 mg/dL; DAIBD score ≥60
Hisamatsu et al. (2014)5	Japanese consensus statements	-	The optimal dose of 5-ASA for adult patients, 2.25–3.00 g/day. Sulfasalazine is also used, the optimal dose is 3–4 g/day.
Hatemi et al. (2016)3	Retrospective (multidisciplinary center)	16	10 of 16 patients (62.5%) achieved remission and did not relapse during the 89.3±64.5 mo

5-ASA, 5-aminosalicylic acid; DAIBD, disease activity index for intestinal Behçet's disease.

Table 2

Corticosteroid Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Nakase et al. (2001)6	Case report	1	PSL 40 mg+intravenous dexamethasone 2.5 mg every 2 wk	After 4 wk, the endoscopic findings of cecal ulcer revealed healing
Toda et al. (2002)7	Case report	1	PSL 40 mg+20 mg of prednisolones injections into the superior and inferior mesenteric arteries	Multiple healing ulcers, but no open ulcers, were observed between the rectum and transverse colon 12 day after intraarterial prednisolone injection.
Yasuo et al. (2003)8	Case report	1	PSL 0.5 mg/kg	The endoscopic findings of esophageal ulcer revealed healing.
Park et al. (2010)16	Retrospective	54	The median dosage of corticosteroid, 0.58 mg/kg (0.39–1.20 mg/kg)
Hisamatsu et al. (2014)5	Japanese consensus statements	-	Weight-based approach of 0.5–1.0 mg/kg per day of prednisolone for 1–2 wk followed by a taper of 5 mg weekly until discontinuation.	-
Saleh and Arayssi (2014)15	Review	-	1 g intravenous methylprednisolone infusions daily for 3 day, followed by 1 mg/kg/day prednisolone tapered slowly	-

PSL, prednisolone.

Table 3

Immunomodulator Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Matsumura et al. (2010)25	Case report	1	• Tacrolimus serum level, 10–15 ng/mL • After 5 mo: 5–10 ng/mL	• Oral tacrolimus was effective for refractory intestinal BD. • Colonoscopy 33 mo after starting tacrolimus revealed complete disappearance of the ascending colon ulceration.
Jung et al. (2012)20	Retrospective	39	• AZA, 2.0–2.5 mg/kg (starting dose, 25 mg or 50 mg/day) • 6-MP, 1.0–1.5 mg/kg (starting dose, 0.5 mg/kg)	• 39 of the 67 patients (58.2%) constantly received thiopurines for maintaining medically or surgically induced remission. • Relapse rates at 1, 2, 3, and 5 yr after remission were 5.8%, 28.7%, 43.7%, and 51.7%.
Hisamatsu et al. (2014)5	Japanese consensus statements	-	AZA, 25–50 mg/day	Japanese consensus statements (the 2nd) recommended thiopurines for refractory intestinal BD such as corticosteroid-dependent or -resistant patients.
Lee et al. (2015)21	Retrospective	77	After surgery: Thiopurine (n=27) • AZA, 2.0–2.5 mg/kg 6-MP, 1.0–1.5 mg/kg 5-ASA (n=50) • 5-ASA, 3–4 g/day	• Postoperative recurrence rate was lower in patients who received postoperative thiopurines (P=0.050). • The hazard ratio for recurrence was 0.636 (95% CI, 0.130–1.016; P=0.053) for postoperative thiopurine use compared with postoperative 5-ASA.
Park et al. (2015)23	Retrospective	83	• AZA, 2.0–2.5 mg/kg (6-MP dose was converted to equivalent AZA) • Starting AZA/6-MP dose, 1.0 mg/kg/day	Leukopenia (WBC count <4,000/µL) during thiopurine maintenance therapy was associated with prolonged remission in patients with IBD and BD during 6 yr.
Hatemi et al. (2016)3	Retrospective	37	AZA, 2.0–2.5 mg/kg/day	65% of patients obtained remission and did not relapse during a mean follow-up of 68.6±43.6 mo.

BD, Behçet's disease; AZA, azathioprine; 6-MP, 6-mercaptopurine; 5-ASA, 5-aminosalicylic acid; WBC, white blood cell.

Table 4

Anti-Tumor Necrosis Factor α Monoclonal Antibody Treatment

Author (year)	Level of published evidence	No. of patients	Regimen	Outcome
Hassard et al. (2001)34	Case report	1	IFX, 4 doses during a 6-mo period	• CDAI decreased from 270 to 13 points by wk 2 and steroid-free remission was sustained. • Endoscopic finding at 10 wk after the first infusion was markedly improved.
Travis et al. (2001)29	Case report	2	• IFX, 3 mg/kg (wk 0, 8) • 5 mg/kg (wk 0, 12, 24)	• Within 10 day the ulcers healed and extraintestinal manifestations were improved. • IFX was used as induction therapy.
Kram et al. (2003)35	Case report	1	IFX, 5 mg/kg (wk 0, 2, 6) according to the regimen of induction therapy for CD	After 2 IFX infusion, ESR and CRP normalized. Colon ulcers revealed healing.
Lee et al. (2007)36	Case report	1	IFX, 5 mg/kg (wk 0, 4)	After 2 IFX infusion, symptoms and laboratory tests, colon ulcers revealed decreased.
Byeon et al. (2007)41	Case report	1	IFX, 5 mg/kg (rescue therapy after a distal ileocecectomy)	IFX was an effective rescue therapy of an unhealed anastomosis site and early recurrent ulcers after surgery.
Ugras et al. (2008)37	Case report	1	IFX 5 mg/kg (wk 0, 2, 6)	After 2 IFX infusion, clinical symptoms improved.
Naganuma et al. (2008)39	Case report	6	IFX induction therapy (5 mg/kg at wk 0, 2, 6), followed by maintenance therapy every 8 wk	4 of 6 patients achieved and maintained remission.
Maruyama et al. (2012)40	Case report	1	IFX induction therapy (5 mg/kg at 0, 2, and 6 wk), followed by maintenance therapy every 8 wk	Successfully maintained in clinical and endoscopic remission by every 8-wk infusion of IFX for 6 yr.
Iwata et al. (2011)24	Retrospective	10	MTX+IFX, 3–5 mg/kg (wk 0, 2, 6 and followed by every 8 until 24 wk)	• Gastrointestinal symptoms and disease-associated complications were improved within 4 wk in all patients. • Ileocecal ulcers were disappeared in 50% patients at 6 mo and 90% patients at 12 mo.
Lee et al. (2013)42	Retrospective	28	IFX, 5 mg/kg (wk 0, 2, 4, 30, 54)	• The clinical response rates at 2, 4, 30, and 54 wk were 75%, 64.3%, 50%, and 39.1%, respectively, with clinical remission rates of 32.1%, 28.6%, 46.2%, and 391. %, respectively. • Older age at diagnosis (≥40 yr), female sex, a longer disease duration (≥5 yr), concomitant immunomodulator use, and achievement of remission at 4 wk found to be predictive factors of sustained response.
Kinoshita et al. (2013)43	Retrospective	15	IFX induction therapy (5 mg/kg at 0, 2, and 6 wk), followed by maintenance therapy every 8 wk	• At wk 10, 12 patients (80%) exhibited a response to IFX, with 8 (53%) in remission with no intestinal symptoms and normal CRP levels. • A response to IFX was maintained in 7 of the 11 patients (64%) available at 12 mo and in 4 of the 8 patients (50%) available at 24 mo.
Tanida et al. (2015)44	A multicenter, openlabel, uncontrolled study	20	ADA, 160 mg (wk 0), 80 mg (wk 2), 40 mg (wk 4), followed by 40 mg every other week for 52 wk (n=6) and 11 patients followed by 80 mg every other week for 52 wk.	• The primary efficacy end point was the percentage of patients with scores of 1 or lower for gastrointestinal symptom and endoscopic assessments at wk 24. • 9 patients (45%) had gastrointestinal symptom and endoscopic assessment scores of 1 or lower at wk 24 of treatment. • 12 patients (60%) had these scores by wk 52. • A total of 9 of 13 patients (69%) taking steroids at baseline were able to taper (n=1) or completely discontinue steroids (n=8) during the study.
Hibi et al. (2016)45	A multicenter, prospective, openlabel, single-arm phase 3 study	18 (intestinal BD, 11; ANB, 2; CPNB,1; VBD, 4)	• IFX, 5 mg/kg (wk 0, 2, and 6 and every 8 wk thereafter until wk 46) • IFX, 10 mg/kg (patients who showed inadequate responses after wk 30)	• The percentage of complete responders was 61% (11/18) at both wk 14 and 30 and remained the same until wk 54. • Intestinal BD patients showed improvement in clinical symptoms along with decrease in CRP levels after wk 2. • Scarring or healing of the principal ulcers was found in more than 80% of these patients after wk 14.

IFX, infliximab; MTX, methotrexate; ADA, adalimumab; BD, Behçet's disease; ANB, acute neurological BD; CPNB, chronic progressive neurological BD; VBD, vascular BD.

Table 1 5-Aminosalicylic Acid Treatment

5-ASA, 5-aminosalicylic acid; DAIBD, disease activity index for intestinal Behçet's disease.

Table 2 Corticosteroid Treatment

PSL, prednisolone.

Table 3 Immunomodulator Treatment

BD, Behçet's disease; AZA, azathioprine; 6-MP, 6-mercaptopurine; 5-ASA, 5-aminosalicylic acid; WBC, white blood cell.

Table 4 Anti-Tumor Necrosis Factor α Monoclonal Antibody Treatment

IFX, infliximab; MTX, methotrexate; ADA, adalimumab; BD, Behçet's disease; ANB, acute neurological BD; CPNB, chronic progressive neurological BD; VBD, vascular BD.