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Intestinal Research 2004;2(2):107-112.
Published online December 22, 2004.
High Dose Midazolam versus Propofol plus Midazolam in Conscious Sedation during Colonoscopy
Sung Won Jung, Sang Kyune Kim, Moon Sung Lee, Bong Min Ko, Su Jin Hong, Chang Beom Ryu, Young Seok Kim, Jin Oh Kim, Chan Sup Shim, Boo Sung Kim
Department of Internal Medicine, Institute for Digestive Research, Soon Chun Hyang University College of Medicine, Bucheon and Seoul, Korea
수면유발 대장내시경 시행시 고용량 Midazolam 투여와 Midazolam, Propofol 병용 투여간의 비교연구
정성원, 김상균, 이문성, 고봉민, 홍수진, 유창범, 김영석, 김진오, 심찬섭, 김부성
순천향대학교 의과대학 내과학교실 소화기 연구소
Abstract
Background/Aims
Colonoscopy under sedation has grown in popularity recently. Midazolam and propofol are generally used for conscious sedation during colonoscopy. In comparison of midazolma, propofol is shorter-acting hypnotic agent and has shorter plasma half-life and it was reported that combined use of propofol with benzodiazepines, barbiturates or opioids enhanced sedative effect by drug interaction. We investigated the effect of high dose midazolam and combined use of midazolam and propofol in conscious sedation during colonoscopy. Methods: We injected midazolam intravenously in 61 patients for sedation before colonoscopy. We divided patients into two groups; one group was injected with additional midazolam (31 patients, high dose midazolam group) and the other was injected with additional propofol (30 patients, combined group). We compared followings in both groups; 1) decrease of systolic and diastolic blood pressure, heart rate, respiration rate per minute, and oxygen saturation rate 2) recovery time 3) degree of amnesia 4) content of patient 5) adverse effects. Results: There is no significant difference between two groups in sex and mean age. In both groups, significant difference was not observed in decrease of systolic and diastolic blood pressure, heart rate, respiration rate, and peripheral blood oxygen saturation rate (p>0.05). Recovery time was shorter in combined group than in high dose midazolam group (p<0.05). Content of patients was higher in combined group (p<0.05), Fatal adverse effect was not found in both groups. Conclusions: Combine use of midazolam and propofol is more effective sedative method than use of high dose midazolam because of shorter recovery time and increased content of patients without increasing adverse effect. (Intestinal Research 2004;2:107-112)
Key Words: Colonoscopy, Conscious sedation, Midazolam, Propofol
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