Herbs are inadvertently regarded safe and harmless because of their natural origin and the experience of long-term use as a folk medicine. However, some herbal medicines are associated with toxicities in the organs such as liver, kidney, skin, or heart. Norpal cactus extract is a kind of herbs which is used for ordinary food in Mexico, and has effects on hypergylcemia and hypercholesterolemia, and inflammation. There has been no particular reports of drug-induced vasculitis by herbal medicine. Here, we present a case of vasculitis that was initially manifestated as acute diarrhea and abdominal pain after ingestion of Norpal cactus extract. (Intest Res 2005;3:85-89)