TLR Signaling in Intestinal Epithelial Tolerance of Commensals |
Sang Kil Lee, Hyo Jong Kim |
Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
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장상피세포의 면역관용에 있어서의 TLR 역할 |
이상길, 김효종 |
경희대학교 의과대학 내과학교실 |
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Abstract |
Toll-like receptors (TLR) is emerging as a key mediator of innate host defense in the intestinal mucosa, crucially involved in maintaining mucosal as well as commensal homeostasis. Through spatial and functional localization of TLR, the normal gut maintains a state of controlled inflammation, By contrast, patients with inflammatory bowel disease (IBD) demonstrated inflammation in response to the normal flora. Recent observations suggest new (patho-) physiologic mechanisms of how functional versus dysfunctional TLR pathways may oppose or favor IBD. A better understanding of the delicate regulation of TLR in the gut may lead to improved treatment for enteric infections and IBD. (Intestinal Research 2005;3:91-95) |
Key Words:
Intestinal epithelium, Toll-like receptor, Tolerance |
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