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- Original Article Acute Diarrhea after Bone Marrow Transplantation
- Hyun Joo Suh, Young Ho Kim, Ji Hyang Kim, Yong Sung Choi, Jeong Kim, Poong Lyul Rhee, Jae J. Kim, Seung Woon Paik, Jong Chul Rhee
- Intestinal Research 2005;3(2):104-109. Published online: December 30, 2005
Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
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Abstract
Background/Aims
A few study have performed the cause of acute diarrhea in patients undergoing bone marrow transplantation (BMT) so far. We analyzed the prevalence of acute diarrhea after BMT, its etiology and its risk factors. Methods: We retrospectively evaluated records of 132 patients undergoing BMT between September 1999 and Jun 2003. Diarrhea had to get its onset from day of admission to day of 100 posttransplant. Results: 95 patients developed acute diarrhea in 132 patients (72% of incidence). The total episodes of diarrhea were 117. Infection was found in 16 of 117 episodes (13.7%). Acute Graft versus host disease was responsible for 9 of 117 episodes (10.3%). Possible etiology of diarrhea was composed of 19 episodes of medication-induced diarrhea (16.2%), 11 episodes of mucositis (9.4%) and 5 episodes of infection (4.3%). Unknown originated diarrhea were 56 episodes (47.9%). Development of diarrhea was not significantly associated with age, sex, underlying disease, BMT conditions and prophylaxis of CMV virus. Conclusions: Acute diarrhea was common in patients undergoing BMT. However, etiology have not clearly evaluated in half of the cases. Further tests to evaluate etiology of acute diarrhea should be investigated. (Intest Res 2005;3:104-109)
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