| Acute Diarrhea after Bone Marrow Transplantation |
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Hyun Joo Suh, Young Ho Kim, Ji Hyang Kim, Yong Sung Choi, Jeong Kim, Poong Lyul Rhee, Jae J. Kim, Seung Woon Paik, Jong Chul Rhee |
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Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
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| 조혈모세포이식 후 발생한 급성 설사에 관한 임상연구 |
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서현주, 김영호, 김지향, 최용성, 김정, 이풍렬, 김재준, 백승운, 이종철 |
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성균관대학교 의과대학 삼성서울병원 내과학교실 |
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| Abstract |
Background/Aims
A few study have performed the cause of acute diarrhea in patients undergoing bone marrow transplantation (BMT) so far. We analyzed the prevalence of acute diarrhea after BMT, its etiology and its risk factors. Methods: We retrospectively evaluated records of 132 patients undergoing BMT between September 1999 and Jun 2003. Diarrhea had to get its onset from day of admission to day of 100 posttransplant. Results: 95 patients developed acute diarrhea in 132 patients (72% of incidence). The total episodes of diarrhea were 117. Infection was found in 16 of 117 episodes (13.7%). Acute Graft versus host disease was responsible for 9 of 117 episodes (10.3%). Possible etiology of diarrhea was composed of 19 episodes of medication-induced diarrhea (16.2%), 11 episodes of mucositis (9.4%) and 5 episodes of infection (4.3%). Unknown originated diarrhea were 56 episodes (47.9%). Development of diarrhea was not significantly associated with age, sex, underlying disease, BMT conditions and prophylaxis of CMV virus. Conclusions: Acute diarrhea was common in patients undergoing BMT. However, etiology have not clearly evaluated in half of the cases. Further tests to evaluate etiology of acute diarrhea should be investigated. (Intest Res 2005;3:104-109) |
| Key Words:
Acute diarrhea, Bone marrow transplantation, Graft versus host disease |
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