| A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia |
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Jun Seok Lee, Young Sook Park, Nam In Kim, Yoon Ju Jo, Seung Hwan Kim, Han Hyo Lee, Moon Hee Song, Dae Won Jun |
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Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea
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| 면역억제제로 유발된 범혈구감소증 후 관해에 이른 궤양성 대장염 1예 |
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이준석, 박영숙, 김남인, 조윤주, 김성환, 이한효, 송문희, 전대원 |
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을지대학교 의과대학 내과학교실 |
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| Abstract |
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Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia. (Intest Res 2008;6:85-89) |
| Key Words:
Azathioprine, Pancytopenia, Colitis, Ulcerative |
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