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- Case Report A Case of Gastrointestinal Amyloidosis in Asymptomatic Multiple Myeloma
- Sae Hee Kim, Yun Jung Lee, Sung Hee Jung, Woo Jin Hyeon, Hyang Ie Lee, Hyeon Woong Yang, Anna Kim, Sang Woo Cha, Dong Wook Kang
- Intestinal Research 2009;7(2):123-128. Published online: December 30, 2009
Departments of Internal Medicine and Pathology, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea
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Abstract
Amyloidosis is a disorder characterized by extracellular deposition of amyloid materials in multiple organs and tissues. Amyloidosis commonly shows a systemic involvement. Gastrointestinal involvement is common in amyloidosis and is usually asymptomatic. The gastrointestinal manifestations include gastroparesis, diarrhea, steatorrhea, constipation, intestinal pseudo-obstruction, and bleeding. The diagnosis of amyloidosis is difficult because there are absence of systemic symptoms and nonspecific endoscopic findings. Asymptomatic multiple myeloma is an asymptomatic plasma-cell proliferative disorder associated with a high risk of progression to symptomatic multiple myeloma or amyloidosis. Recently, we experienced a 60-year-old man who presented with hematochezia and weight loss as manifestations of gastrointestinal amyloidosis involving the stomach and the colon induced in asymptomatic multiple myeloma confirmed by endoscopic biopsies and bone marrow biopsy. We report a case with a review of the literature. (Intest Res 2009;7:123-128)
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