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Intest Res > Volume 9(2); 2011 > Article
Intestinal Research 2011;9(2):144-147.
DOI:    Published online August 30, 2011.
Ulcerative Colitis Complicating Pseudomembranous Colitis of the Right Colon
Hee Rin Joo, Tae Oh Kim, Tae Gyoon Kim, Eun Hee Seo, Jongha Park, Seung Ha Park, Sung Yeon Yang, Young Soo Moon
Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Korea
궤양성 대장염 환자에서 발생한 우측 대장의 위막성 대장염 1예
주희린, 김태오, 김태균, 서은희, 박종하, 박승하, 양성연, 문영수
인제대학교 의과대학 해운대백병원 내과학교실
Clostridium difficile (C. difficile) is a cytotoxin-producing anaerobic gram-positive rod that is responsible for pseudomembranous colitis (PMC). The incidence of C. difficile is increasing in ulcerative colitis (UC) and inflammatory bowel disease patients and is associated with a more severe course, a longer hospital stay, higher financial costs, a greater likelihood of colectomy, and high mortality. PMC may occur anywhere along the intestinal tract, but it is often found in the distal colon. PMC involving the proximal colon with rectosigmoid sparing is rarely reported in patients with UC. We describe the case of a 35-year-old woman in remission from UC who presented with frequent diarrhea and abdominal pain. She was treated with ciprofloxacin for infectious enterocolitis at a local hospital; however, her symptoms did not improve. A colonoscopy revealed yellow-white plaques with edematous, erythematous from the proximal ascending colon to the cecum, and feces positive for C. difficile toxin. She was treated with metronidazole (500 mg, three times a day) for two weeks, and improved rapidly. Physicians should carefully examine the entire colon via colonoscopy, and perform stool exams for C. difficile in patients with UC who have been treated with antibiotics and in those who develop prolonged diarrhea despite medical treatment. (Intest Res 2011;9:144-147)
Key Words: Colitis, Ulcerative, Enterocolitis, Pseudomembranous
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