| Recurrence of Colorectal Neoplasm Cannot Be Predicted by Sonic Hedgehog Expression in the Normal Colonic Tissue |
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Ji Young Lee, Sun-Young Lee, Hye Seung Han, So Young Kim, Sung Noh Hong, Jeong Hwan Kim, In Kyung Sung, Hyung Seok Park, Chan Sup Shim, Choon Jo Jin |
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Departments of Internal Medicine and Pathology, Konkuk University School of Medicine, Seoul, Korea
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| 정상 대장 점막에서의 Sonic Hedgehog 발현과 대장종양 재발 간의 연관성 |
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이지영, 이선영, 한혜승, 김소영, 홍성노, 김정환, 성인경, 박형석, 심찬섭, 진춘조 |
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건국대학교 의학전문대학원 내과학교실, 병리학교실 |
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| Abstract |
Background/Aims
The expression of sonic hedgehog (Shh) in the colon cancer cell has been implicated in colorectal carcinogenesis. However, the association between Shh expression in the normal colonic mucosa and the recurrence of colorectal neoplasm after tumor resection has not been well documented. The aim of the study was to determine the association between Shh expression in the normal colonic mucosa and in the recurrence of colorectal neoplasm. Methods: Fifty-five patients who underwent a long-term follow-up colonoscopy after the colorectal neoplasm resection were included. At the time of the tumor resection, Shh expression in the normal colonic mucosa was examined. The association between Shh expression in the normal colonic mucosa and the recurrence of colorectal neoplasm was analyzed. Results: In total, 97 colorectal neoplasms were detected among 41 subjects after a mean follow-up period of 63 weeks (range 27-254 weeks). Of 55 subjects, 26 (47.3%) exhibited positive Shh expression in the normal colonic tissue, and the recurrence rate did not differ with the degree of Shh expression (P=0.238). The degree of Shh expression was not associated with the number (P=0.389), size (P=0.928), location (P=0.410), pathologic types (P=0.127), or time of recurrence (P=0.711) of the recurred colorectal neoplasm. Conclusions: Most colorectal neoplasm patients show recurrence after the resection and exhibit Shh expression in the normal colonic tissue. The degree of Shh expression in the normal colonic mucosa does not predict the recurrence of colorectal neoplasm. (Intest Res 2012;10: 0-271) |
| Key Words:
Hedgehogs, Colorectal neoplasms, Recurrence |
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